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https://www.readbyqxmd.com/read/27905473/carcinogenic-human-papillomavirus-infection
#1
Mark Schiffman, John Doorbar, Nicolas Wentzensen, Silvia de Sanjosé, Carole Fakhry, Bradley J Monk, Margaret A Stanley, Silvia Franceschi
Infections with human papillomavirus (HPV) are common and transmitted by direct contact. Although the great majority of infections resolve within 2 years, 13 phylogenetically related, sexually transmitted HPV genotypes, notably HPV16, cause - if not controlled immunologically or by screening - virtually all cervical cancers worldwide, a large fraction of other anogenital cancers and an increasing proportion of oropharyngeal cancers. The carcinogenicity of these HPV types results primarily from the activity of the oncoproteins E6 and E7, which impair growth regulatory pathways...
December 1, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27891400/prevalence-of-human-papilloma-virus-infection-in-young-primiparous-women-during-postpartum-period-study-from-a-tertiary-care-center-in-northern-india
#2
Alpana Garg, Vanita Suri, Raje Nijhawan, Neelam Aggarwal, Ritu Aggarwal, Charu Guleria, Mili Thakur
INTRODUCTION: Assessment of high-risk Human Papilloma Virus (HPV) prevalence is important for monitoring long-term decrease in cervical cancer after implementation of the prophylactic HPV vaccination. AIM: To determine the prevalence of high-risk HPV infection and cytological abnormalities in young primiparous women in the age group of 16-26years. MATERIALS AND METHODS: In this cross-sectional study, 214 primiparous women aged 16-26years were recruited from a public tertiary health care center postpartum clinic between June 2013 and May 2014...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27875050/assessment-of-oral-human-papillomavirus-prevalence-in-a-multi-ethnic-pediatric-clinic-population
#3
Vikram Tiku, Chelsie J Todd, Karl Kingsley
The human papillomavirus (HPV) family has been associated with many cancers, including oral cancer. Recent studies have also revealed HPV presence from healthy adult and pediatric patient saliva samples, though much less is known about the oral prevalence of high-risk HPV in healthy children and adolescents. The primary goal of this project was to assess the prevalence of HPV within a pediatric dental clinic using non-invasively collected saliva. In brief, saliva was collected and DNA isolated to screen for HPV strains HPV6, HPV11, HPV16, and HPV18...
November 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27843487/invasive-cervical-cancers-in-the-united-states-botswana-and-kenya-hpv-type-distribution-and-health-policy-implications
#4
Aaron Ermel, Brahim Qadadri, Yan Tong, Omenge Orang'o, Benson Macharia, Doreen Ramogola-Masire, Nicola M Zetola, Darron R Brown
BACKGROUND: More deaths occur in African women from invasive cervical cancer (ICC) than from any other malignancy. ICC is caused by infection with oncogenic types of human papillomavirus (HPV). Co-infection with the human immunodeficiency virus (HIV) accelerates the natural history of ICC, and may influence the HPV type distribution. Because HPV vaccines are available, this malignancy is theoretically preventable, but the vaccines are largely type-specific in protection against infection...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27821079/comparison-of-dna-testing-strategies-in-monitoring-human-papillomavirus-infection-prevalence-through-simulation
#5
Carol Y Lin, Ling Li
BACKGROUND: HPV DNA diagnostic tests for epidemiology monitoring (research purpose) or cervical cancer screening (clinical purpose) have often been considered separately. Women with positive Linear Array (LA) polymerase chain reaction (PCR) research test results typically are neither informed nor referred for colposcopy. Recently, a sequential testing by using Hybrid Capture 2 (HC2) HPV clinical test as a triage before genotype by LA has been adopted for monitoring HPV infections. Also, HC2 has been reported as a more feasible screening approach for cervical cancer in low-resource countries...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27780076/the-burden-of-hpv-associated-cancers-in-two-regions-in-nigeria-2012-2014
#6
E E Jedy-Agba, E O Dareng, S N Adebamowo, M Odutola, E A Oga, F Igbinoba, T Otu, E Ezeome, F Bray, R Hassan, C A Adebamowo
INTRODUCTION: HPV attributable cancers are the second most common infection-related cancers worldwide, with much higher burden in less developed regions. There are currently no country-specific estimates of the burden of these cancers in Nigeria just like many other low and middle income countries. METHODS: In this study, we quantified the proportion of the cancer burden in Nigeria that is attributable to HPV infection from 2012 to 2014 using HPV prevalence estimated from previous studies and data from two population based cancer registries (PBCR) in Nigeria...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27770526/genotypic-distribution-of-hpv-among-women-of-reproductive-age-in-georgia
#7
M Butsashvili, M Kajaia, M Kochlamazashvili, M Zarandia, T Gagua, D Meskhishvili, N Avaliani, G Kamkamidze
Of the 100 types of human papillomaviruses (HPV), approximately 35 infect the genital tract. The viruses are categorized as "high risk" and "low risk" depending on whether they are known to cause cancer or not. Cervical cancer is an important cause of cancer mortality in Georgia, and worldwide. Only limited and incomplete data are available about the epidemiology of HPV infection and related molecular and cellular changes in Georgia. Objectives of our study included the estimation of the prevalence and the distribution of HPV genotypes among women in Georgia...
September 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27754751/distribution-of-vaccine-type-human-papillomavirus-does-not-differ-by-race-or-ethnicity-among-unvaccinated-young-women
#8
Dana Whittemore, Lili Ding, Lea E Widdice, Darron A Brown, David I Bernstein, Eduardo L Franco, Jessica A Kahn
BACKGROUND: Previous studies have demonstrated racial and ethnic differences in the distribution of human papillomavirus (HPV) types among adult women with cervical precancers. The aim of this study was to determine whether the distribution of vaccine-targeted HPV types varies by race/ethnicity among unvaccinated young women. MATERIALS AND METHODS: A secondary analysis was performed using data from four studies of sexually experienced, unvaccinated, 13-26-year-old women...
November 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27746423/beneficial-effects-of-human-papillomavirus-vaccine-for-prevention-of-cervical-abnormalities-in-miyagi-japan
#9
Nobuyoshi Ozawa, Kiyoshi Ito, Toru Tase, Hirohito Metoki, Nobuo Yaegashi
Prevention of cervical cancer has been unsuccessful in Japan because of low rates of cancer screening and vaccination. The Vaccine Adverse Review Committee of the Japanese Government investigated 2,475 adverse events and reported 617 (6.9/100,000) severe cases and 176 (2.0/100,000) cases with chronic pain. The proactive recommendation for human papillomavirus (HPV) vaccination has been suspended since June 2013. In this study, we examined vaccination rate and incidence of abnormal cervical cytology in women aged 20 to 24 years attending cancer screening in Miyagi...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27734976/human-papillomavirus-and-head-and-neck-carcinomas-focus-on-evidence-in-the-babel-of-published-data
#10
P Morbini, M Benazzo
Human papillomavirus (HPV)-associated squamous cell carcinoma of the oropharynx is a well-defined entity mostly affecting young to middle-aged male non-smokers. It is generally associated with a favourable outcome, and for this reason a less intensive therapeutic approach has been proposed for this subset of patients. The incidence of HPV-associated oropharyngeal cancers is rapidly increasing in most Western countries, but detailed epidemiological data are not available for the Italian population. Furthermore, among other head and neck regions, a smaller proportion of oral high-grade dysplasia and cancers seems to depend on HPV infection, whereas its role in laryngeal cancer is recognised as less relevant...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27723194/high-prevalence-of-genital-hpv-infection-among-long-term-monogamous-partners-of-women-with-cervical-dysplasia-or-genital-warts-another-reason-for-hpv-vaccination-of-boys
#11
Filip Rob, Ruth Tachezy, Tomáš Pichlík, Lukáš Rob, Zuzana Kružicová, Eva Hamšíková, Jana Šmahelová, Jana Hercogová
We conducted a cross-sectional study on the occurrence of a specific type of genital human papillomavirus (HPV) among long-term monogamous male partners of women with cervical dysplasia and genital warts. The purpose of the study was to improve knowledge with regards to the management of these couples. The presence of genital HPV-DNA was detected by PCR with broad spectrum primers followed by hybridization. 82 males met the study criteria, 41 in each group. Genital HPV-DNA prevalence was 67.5% in the genital warts group and 72...
October 9, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27699512/synergistic-effect-of-programmed-cell-death-protein%C3%A2-1-blockade-and-secondary-lymphoid-tissue-chemokine-in-the-induction-of-anti-tumor-immunity-by-a-therapeutic-cancer-vaccine
#12
Soheila Moeini, Mohsen Saeidi, Fatemeh Fotouhi, Mahdieh Mondanizadeh, Sadegh Shirian, Alireza Mohebi, Ali Gorji, Amir Ghaemi
The use of DNA vaccines has become an attractive approach for generating antigen-specific cytotoxic CD8(+) T lymphocytes (CTLs), which can mediate protective antitumor immunity. The potency of DNA vaccines encoding weakly immunogenic tumor-associated antigens (TAAs) can be improved by using an adjuvant injected together with checkpoint antibodies. In the current study, we evaluated whether the therapeutic effects of a DNA vaccine encoding human papilloma virus type 16 (HPV-16) E7 can be enhanced by combined application of an immune checkpoint blockade directed against the programmed death-1 (PD-1) pathway and secondary lymphoid tissue chemokine (SLC) also known as CCL21 adjuvant, in a mouse cervical cancer model...
October 3, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27696465/characteristics-of-carcinogenic-human-papillomavirus-infection-in-suzhou-epidemiology-vaccine-evaluation-and-associated-diseases
#13
Wen Jing Li, Hong Xing Xu, Zhao Hua Chen, Wei Dong Xu, Yuan Jian Wu
Human papillomavirus infection is a major health problem and caused substantial benign and malignancy diseases among female and male worldwide. We aim to investigate the epidemiology of high-risk human papillomavirus (HR-HPV) and related diseases in Suzhou population. As well as evaluating the potential benefit of a nine-valent HPV vaccine (regardless of HPV-6 and -11) in Suzhou. A total of 40,108 people aged 13-89 years were retrospectively examined by database retrieval from 2010 to 2015. Thirteen genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 66) of HR-HPV were detected using Tellgenplex™ xMAP™ HPV DNA Test assay...
October 3, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27673362/anal-squamous-intraepithelial-lesions-and-hpv-among-young-black-men-who-have-sex-with-men
#14
Kristin Keglovitz, Andrew D Richardson, Nicola Lancki, Tim Walsh, John A Schneider
PURPOSE: Limited data are available on anal squamous intraepithelial lesions (ASILs) and anal human papillomavirus (HPV) infection in young, black populations. The purpose of this study was to examine the prevalence of and relationships between ASILs and high-risk HPV infection in a young (<30 years of age), predominately black, men who have sex with men (MSM) population. METHODS: Results of anal cytology and HPV DNA were gathered for 83 individuals. RESULTS: Forty-two percent of individuals (35) had atypical squamous cells of undetermined significance and 33% (27) had low-grade intraepithelial lesion by cytology...
September 27, 2016: LGBT Health
https://www.readbyqxmd.com/read/27659129/rare-subtype-s-and-frequency-of-multi-viral-subtype-high-risk-human-papilloma-virus-infection-in-high-grade-squamous-intraepithelial-lesion-and-squamous-cell-carcinoma-in-a-cervical-carcinoma-prevalent-developing-country-a-multiplex-real-time-polymerase-chain
#15
Shabnam Akhter, Pradip Manna, Mohammed Kamal, C James Sung, W Dwayne Lawrence, M Ruhul Quddus
BACKGROUND: Bangladesh, with a population of 160 million and nearly half being women, has the 4th highest rate of cervical carcinoma deaths in the world. It is projected that ∼500,000 of these women would die of this entirely preventable cancer by 2030. HPV vaccination is not widely offered in Bangladesh. This pilot study is designed to find out the prevalence of rare and multi-viral high-risk HPV (hrHPV) subtype(s) infection which may help strategize a large scale vaccination program in tackling cervical carcinoma in the country...
2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27641071/cervical-cytological-abnormalities-and-human-papilloma-virus-infection-in-women-infected-with-hiv-in-southern-india
#16
Suchitra Thunga, Anusmitha Andrews, John Ramapuram, Kapaettu Satyamoorthy, Hema Kini, B Unnikrishnan, Prabha Adhikari, Prakhar Singh, Shama Prasada Kabekkodu, Samatha Bhat, Anagha Kadam, Avinash K Shetty
AIM: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. METHODS: A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. RESULTS: The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38...
September 19, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27640170/designing-of-epitope-focused-vaccine-by-targeting-e6-and-e7-conserved-protein-sequences-an-immuno-informatics-approach-in-human-papillomavirus-58-isolates
#17
Sabrina Nusrat Sabah, Md Amran Gazi, Rahvia Alam Sthity, Amena Binte Husain, Salwa Abdul Quyyum, Mustafizur Rahman, Md Rezaul Islam
Human papillomavirus (HPV) is a DNA virus that belongs to the papillomavirus family and is capable of infecting humans. Currently, few vaccines are available to prevent infection by HPV. However, they are not so much effective and provide little benefit to women who have already been infected with HPV. The aim of this study was to design epitope-based vaccines of HPV58 by targeting E6 and E7 proteins of HPV58. Proteomic sequences were retrieved from different isolates at different time periods and later analyzed by performing alignment of these sequences...
September 17, 2016: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/27631732/economic-evaluation-of-screening-strategies-combined-with-hpv-vaccination-of-preadolescent-girls-for-the-prevention-of-cervical-cancer-in-vientiane-lao-pdr
#18
Phetsavanh Chanthavilay, Daniel Reinharz, Mayfong Mayxay, Keokedthong Phongsavan, Donald E Marsden, Lynne Moore, Lisa J White
BACKGROUND: Several approaches to reduce the incidence of invasive cervical cancers exist. The approach adopted should take into account contextual factors that influence the cost-effectiveness of the available options. OBJECTIVE: To determine the cost-effectiveness of screening strategies combined with a vaccination program for 10-year old girls for cervical cancer prevention in Vientiane, Lao PDR. METHODS: A population-based dynamic compartment model was constructed...
2016: PloS One
https://www.readbyqxmd.com/read/27631358/prevalence-of-9-valent-human-papillomavirus-types-by-race-ethnicity-in-the-prevaccine-era-united-states-2003-2006
#19
Gui Liu, Elizabeth R Unger, Susan Hariri, Martin Steinau, Lauri E Markowitz
Before any vaccine introduction, overall DNA prevalence of any 9-valent human papillomavirus (9vHPV) types, HPV 31/33/45/52/58, and HPV 16/18 was 16.0%, 9.5%, and 6.2%, respectively, among female participants in National Health and Nutrition Examination Survey. Non-Hispanic black females were more likely to have infection with HPV 31/33/45/52/58, but not HPV 16/18, compared to non-Hispanic white females.
October 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27622018/intra-cheek-immunization-as-a-novel-vaccination-route-for-therapeutic-vaccines-of-head-and-neck-squamous-cell-carcinomas-using-plasmo-virus-like-particles
#20
Rodney Macedo, Juliette Rochefort, Maude Guillot-Delost, Kae Tanaka, Aline Le Moignic, Clara Noizat, Claude Baillou, Véronique Mateo, Antoine F Carpentier, Eric Tartour, Chloé Bertolus, Bertrand Bellier, Géraldine Lescaille, François M Lemoine
Despite current therapy, head and neck squamous cell carcinomas (HNSCCs) arising from various mucosal sites of the upper aero-digestive tract frequently relapse in a loco-regional manner and have a poor prognosis. Our objective was to validate an innovative mucosal route of vaccination using plasmo virus-like particles (pVLPs) in a pre-clinical orthotopic model of HNSCCs. For this purpose, we used pVLP-E7, that are plasmid DNA encoding retroviral virus-like particles carrying a truncated E7 oncoprotein from HPV-16 as antigen model, to vaccinate mice bearing pre-established TC-1 tumors implanted into the buccal mucosa...
July 2016: Oncoimmunology
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