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Hpv DNA vaccine

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https://www.readbyqxmd.com/read/29344211/prevalence-of-hpv-infection-among-hiv-positive-and-hiv-negative-women-in-central-eastern-italy-strategies-of-prevention
#1
Edoardo Tartaglia, Katia Falasca, Jacopo Vecchiet, Giovanna Paola Sabusco, Giovanna Picciano, Roberto Di Marco, Claudio Ucciferri
The present cross-sectional-study aimed to determine the prevalence of human papillomavirus (HPV)-genotypes among human immunodeficiency virus (HIV)-positive and -negative women in Central/Eastern Italy, and to identify the optimal strategies for effective HPV-prevention in each group. A representative sample of HIV-negative (150/200) and -positive (50/200) women, who underwent cervico-vaginal-swabbing. Swabs were analysed for a cytological screening and for a HPV-DNA-genotyping-test. A total of 66/200 swabs resulted HPV-positive...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29330557/linear-doggybone-dna-vaccine-induces-similar-immunological-responses-to-conventional-plasmid-dna-independently-of-immune-recognition-by-tlr9-in-a-pre-clinical-model
#2
Alex Allen, Chuan Wang, Lisa J Caproni, Gessa Sugiyarto, Elena Harden, Leon R Douglas, Patrick J Duriez, Kinga Karbowniczek, Jon Extance, Paul J Rothwell, Ifeayinwa Orefo, John P Tite, Freda K Stevenson, Christian H Ottensmeier, Natalia Savelyeva
Vaccination with DNA that encodes cancer antigens is a simple and convenient way to raise immunity against cancer and has already shown promise in the clinical setting. Conventional plasmid DNA is commonly used which together with the encoded antigen also includes bacterial immunostimulatory CpG motifs to target the DNA sensor Toll-like receptor 9. Recently DNA vaccines using doggybone DNA (dbDNA™), have been developed without the use of bacteria. The cell-free process relies on the use of Phi29 DNA polymerase to amplify the template followed by protelomerase TelN to complete individual closed linear DNA...
January 12, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29316817/therapeutic-dna-vaccines-for-human-papillomavirus-and-associated-diseases
#3
Max A Cheng, Emily Farmer, Claire Huang, John Lin, Chien-Fu Hung, T-C Wu
Human papillomavirus (HPV) has long been recognized as the causative agent of cervical cancer. High-risk HPV types 16 and 18 alone, are responsible for over 70% of all cases of cervical cancers. More recently, HPV has been identified as an etiological factor for several other forms of cancers, including oropharyngeal, anogenital, and skin. Thus, the association of HPV with these malignancies creates opportunity for the control of these HPV lesions and HPV-associated malignancies through immunization. Strategies to prevent or to therapeutically treat HPV infections have been developed and are still pushing innovative boundaries...
January 9, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29315288/the-promise-of-immunotherapy-in-anal-squamous-cell-carcinoma-a-novel-approach-for-an-orphan-disease
#4
Benny Johnson, Cathy Eng
An estimated 8200 men and women in the United States will receive a diagnosis of squamous cell carcinoma of the anal canal (SCCA) in 2017. Although SCCA is rare, accounting for 2.6% of gastrointestinal cancers, its incidence rate has been steadily increasing over the last few decades in the United States and around the world. More than 90% of cases of SCCA occur in the context of prior human papillomavirus (HPV) infection. To date, preventive vaccinations against HPV remain markedly underutilized. Most patients who have SCCA present with locoregional disease that is cured with chemoradiation...
December 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29314780/hpv-16-targeted-dna-vaccine-expression-the-role-of-purification
#5
Ana M Almeida, Joana Tomás, Patrícia Pereira, João A Queiroz, Fani Sousa, Ângela Sousa
DNA vaccines have come to light in the last decades as an alternative method to prevent many infectious diseases, but they can also be used for the treatment of specific diseases, such as cervical cancer caused by Human Papillomavirus (HPV). This virus produces E6 and E7 oncoproteins, which alter the cell cycle regulation and can interfere with the DNA repairing system. These features can ultimately lead to the progression of cervical cancer, after cell infection by HPV. Thus, the development of a DNA vaccine targeting both proteins arises as an interesting option in the treatment of this pathology...
January 5, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/29310590/oral-human-papillomavirus-dna-detection-in-hiv-positive-men-prevalence-predictors-and-co-occurrence-at-anal-site
#6
Alessandra Vergori, Anna Rosa Garbuglia, Pierluca Piselli, Franca Del Nonno, Catia Sias, Federico Lupi, Daniele Lapa, Andrea Baiocchini, Claudia Cimaglia, Marco Gentile, Andrea Antinori, Maria Capobianchi, Adriana Ammassari
BACKGROUND: HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of nonavalent vaccine should be investigated. Aim was to describe prevalence and predictors of oral HPV detection in HIV-positive men, with attention to nonavalent vaccine-targeted HPV types. Further, co-occurrence of HPV DNA at oral cavity and at anal site was assessed. METHODS: This cross-sectional, clinic-based study included 305 HIV-positive males (85...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29289562/vaginal-and-anal-human-papillomavirus-infection-and-seropositivity-among-female-sex-workers-in-amsterdam-the-netherlands-prevalence-concordance-and-risk-factors
#7
E Marra, N Kroone, E Freriks, C L van Dam, C J Alberts, A A Hogewoning, S Bruisten, A van Dijk, M M Kroone, T Waterboer, M F Schim van der Loeff
BACKGROUND: We studied prevalence, risk factors and concordance of vaginal and anal HPV infection and L1 seropositivity among female sex workers (FSW) in Amsterdam. METHODS: In 2016, FSW aged ≥18 years having a sexually transmitted infections (STI) consultation were invited to participate. Participation entailed taking vaginal and anal self-swabs. Demographics and sexual behaviour data were collected. HPV DNA was analysed using the SPF10-PCR-DEIA-LiPA25-system-v1...
December 28, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29286606/human-papilloma-virus-genotype-distribution-in-cervical-lesions-in-zanjan-iran
#8
Shahrzad Ahmadi, Hossein Goudarzi, Ahmad Jalilvand, Abdolreza Esmaeilzadeh
Objective: Cervical cancer is one of the most common cancers among women all over the world, and main cause is persistent infection with high risk human papillomavirus (HPV) strains. It has been reported that the distribution and prevalence of HPV types varies by geographical region, so that this is important for prevention by type-specific vaccines. The aim of current study was to determine the genotype distribution of HPV using the INNO-LiPA genotyping assay in Zanjan province, North West Iran. Methods: A total of 112 formalin-fixed paraffin embedded (FFPE) tissue samples from cases of low-grade intraepithelial lesion (LSIL), high-grade intraepithelial lesion (HSIL) and squamous cell carcinoma (SCC) were collected...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29274250/an-exosome-based-vaccine-platform-imparts-cytotoxic-t-lymphocyte-immunity-against-viral-antigens
#9
Simona Anticoli, Francesco Manfredi, Chiara Chiozzini, Claudia Arenaccio, Eleonora Olivetta, Flavia Ferrantelli, Antonio Capocefalo, Emiliana Falcone, Anna Ruggieri, Maurizio Federico
Exosomes are 50-150 nm sized nanovesicles released by all eukaryotic cells. We very recently described a method to engineer exosomes in vivo with the E7 protein of Human Papilloma Virus (HPV). This technique consists in the intramuscular injection of a DNA vector expressing HPV-E7 fused at the C-terminus of an exosome-anchoring protein, i.e., Nefmut , we previously characterized for its high levels of incorporation in exosomes. In this configuration, the ∼11 kDa E7 protein elicited a both strong and effective antigen-specific cytotoxic T lymphocyte (CTL) immunity...
December 23, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29273425/supercharged-green-fluorescent-protein-delivers-hpv16e7-dna-and-protein-into-mammalian-cells-in-vitro-and-in-vivo
#10
Fatemeh Motevalli, Azam Bolhassani, Shilan Hesami, Sepideh Shahbazi
Macromolecules including DNA and proteins serve as important human therapeutics but are limited by their general inability to cross cell membranes. Supercharged proteins have been known as potent tools for delivery of macromolecules into mammalian cells. Thus, the use of these delivery systems is important to reduce the human papillomavirus (HPV)-associated malignancies through improvement of vaccine modalities. In this study, we used a supercharged green fluorescent protein (+36 GFP) for delivery of the full-length HPV16 E7 DNA and protein into mammalian cells and evaluated immune responses, and protective/therapeutic effects of different formulations in C57BL/6 tumor mice model...
December 19, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29224043/identification-of-human-papillomavirus-hpv-subtype-in-oral-cancer-patients-through-microarray-technology
#11
Soung Min Kim, Ik Jae Kwon, Hoon Myoung, Jong Ho Lee, Suk Keun Lee
PURPOSE: Human papilloma virus (HPV) is the main source of cervical cancer. Many recent studies have revealed the prevalence and prognosis of HPV associated with oropharyngeal squamous cell carcinoma, but fewer reports have evaluated HPV in oral squamous cell carcinoma (OSCC). The purpose of this study was to determine the prevalence and prognosis of HPV associated with OSCC according to HPV and tumor types. MATERIALS AND METHODS: We used a DNA chip kit (MY-HPV chip kit ®, Mygene Co...
December 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29185272/prevalence-of-human-papillomavirus-genotypes-and-precancerous-cervical-lesions-in-a-screening-population-in-the-republic-of-korea-2014-2016
#12
Yung Taek Ouh, Kyung Jin Min, Hyun Woong Cho, Moran Ki, Jin Kyoung Oh, Sang Yop Shin, Jin Hwa Hong, Jae Kwan Lee
OBJECTIVE: Knowledge regarding the prevalence and distribution of human papillomavirus (HPV) genotyping in healthy women is important in establishing strategies for cervical cancer screening and HPV vaccination. METHODS: A total of 18,170 women who visited a Korean Medical Institute for health check-ups were recruited retrospectively; they underwent HPV genotyping and conventional cervical cytology. An HPV DNA test was performed using the Anyplex™ II HPV 28 detection system (Seegene) or HPV Liquid Bead Microarray (Osang Healthcare)...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29180538/prevalence-and-sociodemographic-correlates-of-cervicovaginal-human-papillomavirus-hpv-carriage-in-a-cross-sectional-multiethnic-community-based-female-asian-population
#13
Su Pei Khoo, Nirmala Bhoo-Pathy, Siew Hwei Yap, Mohd Khairul Anwar Shafii, Nazrilla Hairizan Nasir, Jerome Belinson, ShriDevi Subramaniam, Pik Pin Goh, Ming Zeng, Hong Dong Tan, Patti Gravitt, Yin Ling Woo
OBJECTIVES: Cervical cancer is a largely preventable disease, and the strategic implementation of a cervical cancer prevention programme is partly dependent on the impact of human papillomavirus (HPV) infection interpreted within the context of the country's sociodemographic attributes. The objective of this study is to determine the prevalence of cervicovaginal HPV infection among a healthy, community-based, multiethnic Malaysian population. The HPV prevalence was subsequently correlated to the individual's sociodemographics and sexual/reproductive history...
November 27, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29157596/molecular-epidemiology-and-phylogenetic-analysis-of-human-papillomavirus-infection-in-women-with-cervical-lesions-and-cancer-from-the-coastal-region-of-ecuador
#14
Cesar H Bedoya-Pilozo, Lex G Medina Magües, Maylen Espinosa-García, Martha Sánchez, Johanna V Parrales Valdiviezo, Denisse Molina, María A Ibarra, María Quimis-Ponce, Karool España, Karla E Párraga Macias, Nancy V Cajas Flores, Solon A Orlando, Jorge A Robalino Penaherrera, Peter Chedraui, Saul Escobar, Rita D Loja Chango, Cecibel Ramirez-Morán, Jasson Espinoza-Caicedo, Sunny Sánchez-Giler, Celia M Limia, Yoan Alemán, Yudira Soto, Vivian Kouri, Andrés C A Culasso, Inés Badano
The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases...
November 17, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29150417/using-facebook-to-recruit-young-australian-men-into-a-cross-sectional-human-papillomavirus-study
#15
Roopa Das, Dorothy A Machalek, Edmund G Molesworth, Suzanne M Garland
BACKGROUND: Young men can be difficult to engage in health research using traditional methods of recruitment. Social networking sites are increasingly being used to recruit participants into health research, due to their cost effectiveness, overall generalizability, and wide reach. OBJECTIVE: The aim of this study was to determine the feasibility of using Facebook to recruit young Australian men into a human papillomavirus (HPV) prevalence study. METHODS: We recruited male permanent residents of Australia, aged 18 to 35 years, into the HPV in Young Males (HYM) study through targeted advertising placed on Facebook...
November 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29149434/enhancement-of-therapeutic-dna-vaccine-potency-by-melatonin-through-inhibiting-vegf-expression-and-induction-of-antitumor-immunity-mediated-by-cd8-t-cells
#16
Sanaz Baghban Rahimi, Alireza Mohebbi, Gelareh Vakilzadeh, Peyvand Biglari, Soodeh Razeghi Jahromi, Seyed Reza Mohebi, Sadegh Shirian, Ali Gorji, Amir Ghaemi
To be effective, therapeutic cancer vaccines should stimulate both an effective cell-mediated and a robust cytotoxic CD8+ T-cell response against human papillomavirus (HPV)-infected cells to treat the pre-existing tumors and prevent potential future tumors. In this study, the therapeutic experiments were designed in order to evaluate antitumor effect against the syngeneic TC-1 tumor model. The anti-tumor efficacy of a HPV-16 E7 DNA vaccine adjuvanted with melatonin (MLT) was evaluated in a C57BL/6 mouse tumor model by measuring tumor growth post vaccination and the survival rate of tumor-bearing mice, analyzing the specific lymphocyte proliferation responses in control and vaccinated mice by MTT assay...
November 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29144546/presence-of-infection-and-analysis-of-hpv-subtypes-in-girls-younger-than-9-years-old-attended-at-a-referral-service-in-esp%C3%A3-rito-santo-brazil
#17
Mariana Penha De Nadai Sartori, Lidiane Pignaton Agostini, Thaís Tristão Tovar, Raquel Silva Dos Reis, Raquel Spinassé Dettogni, Eldamária de Vargas Wolfgramm Dos Santos, Antônio Chambô Filho, Iúri Drumond Louro
PURPOSE: Human papillomavirus is found in adults and adolescents and is associated with genital warts and cervical cancer. However, it has been detected in girls younger than 10 years old. Currently, there are no prevention methods for this age group, since it is not considered a risk group. The aim of this study was to evaluate the presence of infection and HPV subtype in girls under 9 years old attended at a referral service in the State of Espírito Santo, Brazil. METHODS: Forty-three girls younger than 9 years old had gynecological brush samples collected from vulval and perineal/anal regions...
November 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29143101/candidate-biomarkers-in-the-cervical-vaginal-fluid-for-the-self-diagnosis-of-cervical-precancer
#18
REVIEW
Xaveer Van Ostade, Martin Dom, Wiebren Tjalma, Geert Van Raemdonck
PURPOSE: Despite improvement in vaccines against human papilloma virus (HPV), the causative agent of cervical cancer, screening women for cervical precancer will remain indispensable in the coming 30-40 years. A simple test that could be performed at home or at a doctor's practice and that informs the woman whether she is at risk would significantly help make a broader group of patients who aware that they need medical treatment. Cervical vaginal fluid (CVF) is a body fluid that is very well suited for such a test...
November 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29109779/serum-immune-profiling-for-early-detection-of-cervical-disease
#19
Radwa Ewaisha, Gitika Panicker, Paul Maranian, Elizabeth R Unger, Karen S Anderson
BACKGROUND: The most recent (2012) worldwide estimates from International Agency for Research on Cancer indicate that approximately 528,000 new cases and 270,000 deaths per year are attributed to cervical cancer worldwide. The disease is preventable with HPV vaccination and with early detection and treatment of pre-invasive cervical intraepithelial neoplasia, CIN. Antibodies (Abs) to HPV proteins are under investigation as potential biomarkers for early detection. METHODS: To detect circulating HPV-specific IgG Abs, we developed programmable protein arrays (NAPPA) that display the proteomes of two low-risk HPV types (HPV6 and 11) and ten oncogenic high-risk HPV types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52 and 58)...
2017: Theranostics
https://www.readbyqxmd.com/read/29074191/prevalence-genotyping-and-correlates-of-anogenital-hpv-infection-in-a-population-based-sample-of-women-in-puerto-rico
#20
A P Ortiz, J Romaguera, C M Pérez, D González, C Muñoz, L González, E Marrero, G Tortolero-Luna, E Suárez, J Palefsky
BACKGROUND: Oncogenic HPV infection is associated to anogenital cancer. We estimate the prevalence and correlates of anogenital HPV infection among a population-based sample of women aged 16-64 years living in the metropolitan area of Puerto Rico. METHODS: 564 women completed face-to-face and computer assisted interviews and self-collected anal and cervical specimens. HPV DNA testing used MY09/MY11 consensus HPV L1 primers and beta-globin as an internal control for sample amplification...
December 2016: Papillomavirus Research
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