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Hpv DNA vaccine

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https://www.readbyqxmd.com/read/28334393/adjuvant-human-papillomavirus-vaccination-for-secondary-prevention-a-systematic-review
#1
Gregory R Dion, Stephanie Teng, Leslie R Boyd, Antonia Northam, Charlotte Mason-Apps, Dorice Vieira, Milan R Amin, Ryan C Branski
Importance: Human papillomavirus (HPV) vaccination is recommended for children and younger adults but not older adults or those with prior HPV exposure, leaving a large portion of the population at risk for HPV-mediated disease. Emerging data suggest a possible role for vaccination as an adjuvant treatment for individuals with HPV-related clinical disease. Objective: To systematically review the literature regarding HPV vaccination for secondary disease prevention after treatment of active clinical disease across disease sites to serve as a platform for the management of HPV-related disease of the head and neck...
March 23, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28295672/the-prevalence-of-hpv-infections-in-hpv-vaccinated-women-from-the-general-population
#2
Eva Hamsikova, Jana Smahelova, Viera Ludvikova, Martina Salakova, Jana Rychla, Jana Skrenkova, Lukas Rob, Ruth Tachezy
Currently, three prophylactic HPV vaccines are commercially available to prevent HPV 16/18 infection and associated lesions. The aim of the study was to assess markers of HPV infection in women/girls before vaccination and to ascertain the prevalence and spectrum of post-vaccination HPV types. Three hundred and thirty subjects of which 75 were virgins were enrolled. Before the first dose of the HPV vaccine and 1, 3 and 5 years after the completion of HPV vaccination, the samples for cytology, HPV detection and anti-HPV antibody response were taken...
March 15, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28277144/molecular-tests-potentially-improving-hpv-screening-and-genotyping-for-cervical-cancer-prevention
#3
Ana Gradíssimo, Robert D Burk
Human papillomavirus (HPV)-related cancers can be averted by type-specific vaccination (primary prevention) and/or through detection and ablation of precancerous cervical lesions (secondary prevention). This review presents current challenges to cervical cancer screening programs, focusing on recent molecular advances in HPV testing and potential improvements on risk stratification. Areas covered: High-risk (HR)-HPV DNA detection has been progressively incorporated into cervix cancer prevention programs based on its increased sensitivity...
February 20, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28212457/papillomaviruses-a-systematic-review
#4
Rodrigo Pinheiro Araldi, Suely Muro Reis Assaf, Rodrigo Franco de Carvalho, Márcio Augusto Caldas Rocha de Carvalho, Jacqueline Mazzuchelli de Souza, Roberta Fiusa Magnelli, Diego Grando Módolo, Franco Peppino Roperto, Rita de Cassia Stocco, Willy Beçak
In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomaviruses. Moreover, the obtained data contributes to the development of strategies against the clinical consequences of bovine papillomaviruses (BPV) that have led to drastic hazards to the herds...
February 16, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28181989/-influence-of-age-in-the-prevalence-of-high-risk-human-papiloma-virus-in-women-with-pre-neoplasic-cervical-lesions-in-navarra-spain
#5
María Rosario Mercado Gutiérrez, Carolina Arean Cuns, María Luisa Gómez Dorronsoro, Irene Paniello Alastruey, Fermin Mallor Giménez, Maria Dolores Lozano Escario, Mercedes Santamaría Martínez
OBJECTIVE: Cervical carcinoma (CC) is the second cause of death among women aged 15 and 44 in Spain. CC is linked to hig-risk human papillomavirus (HR-HPV) infection and its prevalence varies according age and geographical region. The awereness of the latter is essential for public health prevention efforts. The aim was to study the age related in HR-HPV genotypes in cytologies with squamous intraepithelial lesion (SIL). METHODS: From a total of 67,935 ginecologic cytologies over a four-year period, we selected cytologic specimens with SIL...
February 9, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28178116/genital-human-papillomavirus-infection-in-indian-hiv-seropositive-men-who-have-sex-with-men
#6
Anantharam Raghavendran, Alexandra L Hernandez, Shelly Lensing, Manu Gnanamony, Rajiv Karthik, Murgesan Sivasubramanian, Rajesh Kannangai, Priya Abraham, Dilip Mathai, Joel M Palefsky
BACKGROUND: The incidence of penile cancer in Indian men is high. Little is known about genital human papillomavirus (HPV) infection in Indian HIV-seropositive men who have sex with men (MSM), a population that may be at particularly high risk for genital HPV infection and, potentially, penile cancer. In this study, we assessed the prevalence and risk factors for genital HPV infection in this population. DESIGN AND METHODS: Three hundred HIV-seropositive MSM were recruited from 2 clinical sites in India...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28166180/therapeutic-vaccine-against-primate-papillomavirus-infections-of-the-cervix
#7
Emeline Ragonnaud, Anne-Marie C Andersson, Silmi Mariya, Anders G Pedersen, Robert D Burk, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Alfredo Nicosia, Joko Pamungkas, Diah Iskandriati, Peter J Holst
Currently available prophylactic vaccines have no therapeutic efficacy for preexisting human papillomavirus (HPVs) infections, do not target all oncogenic HPVs and are insufficient to eliminate the burden of HPV induced cancer. We aim to develop an alternative HPV vaccine which is broadly effective and capable of clearing preexisting infection. In an initial attempt to develop a broadly reactive therapeutic vaccine, we designed a putative papillomavirus (PV) ancestor antigen (circulating sequence derived antigenic sequences E1E2-CDSE1E2) based on the conserved E1 and E2 protein sequences from existing oncogenic HPV strains...
February 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28118086/a-plant-protein-signal-sequence-improved-humoral-immune-response-to-hpv-prophylactic-and-therapeutic-dna-vaccines
#8
Silvia Massa, Francesca Paolini, Gianfranca Curzio, Marcelo Nazario Cordeiro, Elena Illiano, Olivia Costantina Demurtas, Rosella Franconi, Aldo Venuti
Signal sequences (ss) play a critical role in the sorting of nascent secretory and membrane proteins. This function has been conserved from bacteria through eukaryotes, although ss appear diverse in length and amino acid composition. Sorting of proteins is also critical to instruct antigens for a proper immunological response. Thus, a plant ss was used to drive Human Papillomavirus (HPV) model antigens into the human secretory pathway: the HPV16 E7 oncoprotein, its chimera with the coat protein (CP) of the Potato Virus X (PVX), the first 200 amino acids of the HPV16 minor capsid protein L2 (known to harbour cross-reacting epitopes) and its chimera with E7 gene...
February 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28115985/human-papillomavirus-infection-in-anal-intraepithelial-lesions-from-hiv-infected-cuban-men
#9
Celia M Limia, Yudira Soto, Yanara García, Orestes Blanco, Vivian Kourí, María V López, María E Toledo, Lissette Pérez, Yoanna Baños, Yaniris Caturla, Francisco Aguayo
BACKGROUND: An association between HPV infection and progression to anal squamous intraepithelial lesions (ASIL) has been established, specifically in high-risk populations such as HIV-infected men. In this population, anal cancer is one of the most common non-AIDS-defining malignancies. METHODS: A cross-sectional study to detect anal lesions and HPV infection was performed. Anal mucosa samples were collected from 56 HIV-infected men from Cuba. The cytological diagnosis was done according to Bethesda 2001 System...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28114440/prevalence-of-genital-human-papillomavirus-infection-and-human-papillomavirus-vaccination-rates-among-us-adult-men-national-health-and-nutrition-examination-survey-nhanes-2013-2014
#10
Jasmine J Han, Thomas H Beltran, John W Song, John Klaric, Y Sammy Choi
Importance: Human papillomavirus (HPV) is a common sexually transmitted infection that is a major cause of noncervical anogenital and oropharyngeal cancers. Prophylactic HPV vaccine is available for primary prevention. However, the population prevalence data for male genital HPV infection is not well known, while the HPV vaccination coverage is low in the United States. Objectives: To estimate the prevalence of genital HPV infection and the HPV vaccination rate in the United States among adult men and to examine potential risk factors for HPV infection...
January 19, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28102931/the-impact-of-hpv-type-on-colposcopy-performance-in-women-offered-hpv-immunisation-in-a-catch-up-vaccine-programme-a-two-centre-observational-study
#11
Ami Munro, Collette Gillespie, Seonaidh Cotton, Camille Busby-Earle, Kim Kavanagh, Kate Cuschieri, Heather Cubie, Chris Robertson, Louise Smart, Kevin Pollock, Catherine Moore, Timothy Palmer, Margaret E Cruickshank
OBJECTIVE: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy. DESIGN: A two-centre observational study including vaccinated and unvaccinated women. SETTING: Colposcopy clinics serving two health regions in Scotland, UK. POPULATION: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening...
January 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28091335/high-prevalence-of-hpv-infection-in-the-remote-villages-of-french-guiana-an-epidemiological-study
#12
A Adenis, V Dufit, M Douine, F Corlin, G Ayhan, F Najioullah, V Molinie, P Brousse, G Carles, V Lacoste, R Cesaire, M Nacher
Cervical cancer is the second most frequent cancer in women in French Guiana. Studies have shown that populations living in the remote areas of the interior have early sexual debut and that multiple sexual partnerships are common. The objective of the present study was thus to determine the prevalence of human papillomavirus (HPV) infection in these areas. A study was conducted in women aged 20-65 years with previous sexual activity. Women were included on a voluntary basis after using local media and leaders to inform them of the visit of the team...
January 16, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28045981/hpv-genotyping-of-modified-general-primer-amplicons-is-more-analytically-sensitive-and-specific-by-sequencing-than-by-hybridization
#13
Roger Meisal, Trine Ballestad Rounge, Irene Kraus Christiansen, Alexander Kirkeby Eieland, Merete Molton Worren, Tor Faksvaag Molden, Øyvind Kommedal, Eivind Hovig, Truls Michael Leegaard, Ole Herman Ambur
Sensitive and specific genotyping of human papillomaviruses (HPVs) is important for population-based surveillance of carcinogenic HPV types and for monitoring vaccine effectiveness. Here we compare HPV genotyping by Next Generation Sequencing (NGS) to an established DNA hybridization method. In DNA isolated from urine, the overall analytical sensitivity of NGS was found to be 22% higher than that of hybridization. NGS was also found to be the most specific method and expanded the detection repertoire beyond the 37 types of the DNA hybridization assay...
2017: PloS One
https://www.readbyqxmd.com/read/28012703/physicochemical-characterization-and-immunological-properties-of-pichia-pastoris-based-hpv16l1-and-18l1-virus-like-particles
#14
Gaurav Gupta, Reinhard Glueck, Narayan Rishi
There continues to be an urgent need for cost-effective prophylaxis for HPV-associated cancers in socio-economically underdeveloped nations. Presently HPV vaccines, which are commercially available, are adjuvanted virus-like particles (VLPs) expressed from various recombinant expression systems. They have been characterized by different methods as safe, pure, and potent HPV vaccine antigens. We cloned and expressed L1 proteins of HPV16 & 18 in Pichia pastoris and tested their immunogenicity. We observed that HPVL1 proteins (16L1 and 18L1) are expressed in Pichia pastoris at high levels...
December 21, 2016: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28005904/epidemiologic-evaluation-of-human-papillomavirus-type-competition-and-the-potential-for-type-replacement-post-vaccination
#15
Joseph E Tota, Mengzhu Jiang, Agnihotram V Ramanakumar, Stephen D Walter, Jay S Kaufman, François Coutlée, Harriet Richardson, Ann N Burchell, Anita Koushik, Marie Hélène Mayrand, Luisa L Villa, Eduardo L Franco
BACKGROUND: Millions of women have been vaccinated with one of two first-generation human papillomavirus (HPV) vaccines. Both vaccines remain in use and target two oncogenic types (HPVs 16 and 18); however, if these types naturally compete with others that are not targeted, type replacement may occur following reductions in the circulating prevalence of targeted types. To explore the potential for type replacement, we evaluated natural HPV type competition in unvaccinated females. METHODS: Valid HPV DNA typing information was available from five epidemiological studies conducted in Canada and Brazil (n = 14,685; enrollment across studies took place between1993 and 2010), which used similar consensus-primer PCR assays, capable of detecting up to 40 HPV types...
2016: PloS One
https://www.readbyqxmd.com/read/27998015/efficacy-immunogenicity-and-safety-of-the-hpv-16-18-as04-adjuvanted-vaccine-in-chinese-women-aged-18-25%C3%A2-years-event-triggered-analysis-of-a-randomized-controlled-trial
#16
Feng-Cai Zhu, Shang-Ying Hu, Ying Hong, Yue-Mei Hu, Xun Zhang, Yi-Ju Zhang, Qin-Jing Pan, Wen-Hua Zhang, Fang-Hui Zhao, Cheng-Fu Zhang, Xiaoping Yang, Jia-Xi Yu, Jiahong Zhu, Yejiang Zhu, Feng Chen, Qian Zhang, Hong Wang, Changrong Wang, Jun Bi, Shiyin Xue, Lingling Shen, Yan-Shu Zhang, Yunkun He, Haiwen Tang, Naveen Karkada, Pemmaraju Suryakiran, Dan Bi, Frank Struyf
We previously reported the results of a phase II/III, double-blind, randomized controlled study in Chinese women (NCT00779766) showing a 94.2% (95% confidence interval: 62.7-99.9) HPV-16/18 AS04-adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6-month (M) persistent infection (PI) with a mean follow-up of <2 years, and immunogenicity until 7 months post-dose 1. Here, we report efficacy and safety results from an event-triggered analysis with ~3 years longer follow-up, and immunogenicity until M24...
January 2017: Cancer Medicine
https://www.readbyqxmd.com/read/27979747/dna-vaccination-for-cervical-cancer-a-novel-technology-platform-of-rala-mediated-gene-delivery-via-polymeric-microneedles
#17
Ahlam A Ali, Cian M McCrudden, Joanne McCaffrey, John W McBride, Grace Cole, Nicholas J Dunne, Tracy Robson, Adrien Kissenpfennig, Ryan F Donnelly, Helen O McCarthy
HPV subtypes (16, 18) are associated with the development of cervical cancer, with oncoproteins E6 and E7 responsible for pathogenesis. The goal of this study was to evaluate our 'smart system' technology platform for DNA vaccination against cervical cancer. The vaccination platform brings together two main components; a peptide RALA which condenses DNA into cationic nanoparticles (NPs), and a polymeric polyvinylpyrrolidone (PVP) microneedle (MN) patch for cutaneous delivery of the loaded NPs. RALA condensed E6/E7 DNA into NPs not exceeding 100nm in diameter, and afforded the DNA protection from degradation in PVP...
December 12, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27930979/hp91-immunoadjuvant-an-hmgb1-derived-peptide-for-development-of-therapeutic-hpv-vaccines
#18
Somayeh Talebi, Azam Bolhassani, Seyed Mehdi Sadat, Rouhollah Vahabpour, Elnaz Agi, Sepideh Shahbazi
BACKGROUND: High percentage of human cervical malignancy is related to human papillomavirus (HPV) infections. Thus, it is important to find novel non-invasive treatment strategies among various therapeutic HPV vaccines. In current study, we investigated the protective and therapeutic effects of DNA- and protein-based vaccines using HPV16 E7 as a model antigen in tumor mice model. In this line, the full length of high-mobility group box 1 (HMGB1) protein as well as an HMGB1-derived short peptide (Hp91) was used as an adjuvant for stimulating adaptive immunity and developing the potency of these vaccines...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27929754/hpv-16-e5-oncoprotein-is-expressed-in-early-stage-carcinogenesis-and-can-be-a-target-of-immunotherapy
#19
Francesca Paolini, Gianfranca Curzio, Marcelo Nazario Cordeiro, Silvia Massa, Luciano Mariani, Fulvia Pimpinelli, Antonio Carlos de Freitas, Rosella Franconi, Aldo Venuti
HPV16 persistent infection is a well-known condition that precedes human cancer development. High risk HPV E5 proteins cooperate with E6/E7 oncogenes to promote hyper-proliferation of infected cells leading to possible cancer progression. Thus, presence of E5 viral transcripts could be a key marker of active infection and, in turn, a target of immunotherapy. Purpose of the study is to detect E5 transcripts in clinical samples and to explore the activity of novel anti-HPV16 E5 DNA vaccines. HPV transcripts were detected by PCR with specific primers encompassing the splice-donor sites of E5 transcript...
February 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905473/carcinogenic-human-papillomavirus-infection
#20
Mark Schiffman, John Doorbar, Nicolas Wentzensen, Silvia de Sanjosé, Carole Fakhry, Bradley J Monk, Margaret A Stanley, Silvia Franceschi
Infections with human papillomavirus (HPV) are common and transmitted by direct contact. Although the great majority of infections resolve within 2 years, 13 phylogenetically related, sexually transmitted HPV genotypes, notably HPV16, cause - if not controlled immunologically or by screening - virtually all cervical cancers worldwide, a large fraction of other anogenital cancers and an increasing proportion of oropharyngeal cancers. The carcinogenicity of these HPV types results primarily from the activity of the oncoproteins E6 and E7, which impair growth regulatory pathways...
December 1, 2016: Nature Reviews. Disease Primers
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