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inhaled hypertonic saline asthma

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https://www.readbyqxmd.com/read/27624002/allergy-specific-phenome-wide-association-study-for-immunogenes-in-turkish-children
#1
Sefayet Karaca, Ersoy Civelek, Mehmet Karaca, Umit M Sahiner, Riza K Ozgul, Can N Kocabas, Renato Polimanti, Bülent E Sekerel
To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted using ISAAC (International Study of Asthma and Allergies in Children) Phase II tools. We investigated 9 loci involved in different immune functions (ADAM33, ADRB2, CD14, IL13, IL4, IL4R, MS4A2, SERPINE1, and TNF) with respect to 116 traits assessed through blood tests, hypertonic saline challenge tests, questionnaires, and skin prick tests...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27492520/stepping-down-from-combination-asthma-therapy-the-predictors-of-outcome
#2
Heikki O Koskela, Minna K Purokivi, Jouko Kokkarinen
BACKGROUND: Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start stepping down more often than previously. METHODS: In 55 subjects with well controlled asthma and combination therapy, LABAs were discontinued first, followed by ICS dose halving, and then cessation, in six weeks' intervals...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/26908255/-indirect-challenges-from-science-to-clinical-practice
#3
REVIEW
Sandra D Anderson
Indirect challenges act to provoke bronchoconstriction by causing the release of endogenous mediators and are used to identify airway hyper-responsiveness. This paper reviews the historical development of challenges, with exercise, eucapnic voluntary hyperpnoea (EVH) of dry air, wet hypertonic saline, and with dry powder mannitol, that preceded their use in clinical practice. The first challenge developed for clinical use was exercise. Physicians were keen for a standardized test to identify exercise-induced asthma (EIA) and to assess the effect of drugs such as disodium cromoglycate...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26741301/the-influence-of-nebulized-drugs-on-nasal-ciliary-activity
#4
Mieke Boon, Mark Jorissen, Martine Jaspers, Patrick Augustijns, François L Vermeulen, Marijke Proesmans, Kris De Boeck
INTRODUCTION: Nebulized drugs are used in the treatment of cystic fibrosis (CF) lung disease, asthma, and COPD, and increasingly also in other chronic lung diseases. Their use in CF is reasonably evidence based, but this is not so for use in other orphan diseases. Potential side effects often have not been studied. Therefore, we evaluated the influence of nebulized drugs on ciliary activity in an in vitro model. METHODS: We constructed an in vitro nebulization model to examine the effect of drugs on ciliary activity...
August 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/25838089/effect-of-inhaled-corticosteroids-on-bronchial-asthma-in-japanese-athletes
#5
Yoshifumi Hoshino, Toshiyuki Koya, Hiroshi Kagamu, Keisuke Tsukioka, Mio Toyama, Takuro Sakagami, Takashi Hasegawa, Ichiei Narita, Masaaki Arakawa, Eiichi Suzuki
BACKGROUND: Asthma has a higher prevalence in athlete populations such as Olympic athletes than in the general population. Correct diagnosis and management of asthma in athletes is important for symptom control and avoidance of doping accusations. However, few reports are available on asthma treatment in the athlete population in clinical practice. In this study, we focused on the clinical efficacy of inhaled corticosteroid (ICS) for asthma in a Japanese athlete population. METHODS: The study subjects included athletes who visited the Niigata Institute for Health and Sports Medicine, Niigata, Japan for athletic tests and who were diagnosed with asthma on the basis of respiratory symptoms and positive results in a bronchodilator or bronchial provocation test such as exercise, hypertonic saline, or methacholine provocation...
April 2015: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/25761367/mannitol-versus-hypertonic-saline-safety-and-efficacy-of-mannitol-and-hypertonic-saline-in-sputum-induction-and-bronchial-hyperreactivity-assessment
#6
RANDOMIZED CONTROLLED TRIAL
M J Alvarez-Puebla, J M Olaguibel, E Almudevar, A A Echegoyen, C Vela, B de Esteban
Eosinophilic asthma phenotype predicts good response to corticosteroids and associates to asthmatic exacerbations. Sputum induction by hypertonic saline (HS) inhalation is technically demanding. Bronchial hyperresponsiveness (BHR) to osmotic agents indirectly mirrors active airway inflammation. We compared the safety and ability of HS and mannitol to induce sputum and measure BHR. We evaluated the stability of inflammatory phenotypes. We studied 35 non-smoking asthmatics randomized to undergo HS and mannitol challenges on 2 days 1 week apart...
August 2015: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/25344148/inter-society-consensus-document-on-treatment-and-prevention-of-bronchiolitis-in-newborns-and-infants
#7
Eugenio Baraldi, Marcello Lanari, Paolo Manzoni, Giovanni A Rossi, Silvia Vandini, Alessandro Rimini, Costantino Romagnoli, Pierluigi Colonna, Andrea Biondi, Paolo Biban, Giampietro Chiamenti, Roberto Bernardini, Marina Picca, Marco Cappa, Giuseppe Magazzù, Carlo Catassi, Antonio Francesco Urbino, Luigi Memo, Gianpaolo Donzelli, Carlo Minetti, Francesco Paravati, Giuseppe Di Mauro, Filippo Festini, Susanna Esposito, Giovanni Corsello
Acute bronchiolitis is the leading cause of lower respiratory tract infection and hospitalization in children less than 1 year of age worldwide. It is usually a mild disease, but some children may develop severe symptoms, requiring hospital admission and ventilatory support in the ICU. Infants with pre-existing risk factors (prematurity, bronchopulmonary dysplasia, congenital heart diseases and immunodeficiency) may be predisposed to a severe form of the disease. Clinical diagnosis of bronchiolitis is manly based on medical history and physical examination (rhinorrhea, cough, crackles, wheezing and signs of respiratory distress)...
2014: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/24720774/trefoil-factor-peptides-in-serum-and-sputum-from-subjects-with-asthma-and-copd
#8
COMPARATIVE STUDY
Niels-Erik Viby, Lars Pedersen, Thomas Kromann Lund, Hannelouise Kissow, Vibeke Backer, Ebba Nexø, Lars Thim, Steen Seier Poulsen
OBJECTIVE: Trefoil factor peptides (TFF) are secreted onto mucosal surfaces together with mucins and occur in high concentrations in pulmonary secretions from patients with chronic obstructive pulmonary disease (COPD). In the present study, we aimed to explore the concentrations of the peptides in serum and sputum in patients with COPD. MATERIALS AND METHODS: Thirty-five individuals were included in the study, including 11 healthy individuals, 13 indivials with asthma and 11 individuals with COPD...
July 2015: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/24294924/airway-oxidative-stress-in-chronic-cough
#9
Heikki O Koskela, Minna K Purokivi
BACKGROUND: The mechanisms of chronic cough are unclear. Many reactive oxygen species affect airway sensory C-fibres which are capable to induce cough. Several chronic lung diseases are characterised by cough and oxidative stress. In asthma, an association between the cough severity and airway oxidative stress has been demonstrated. The present study was conducted to investigate whether airway oxidative stress is associated with chronic cough in subjects without chronic lung diseases...
2013: Cough
https://www.readbyqxmd.com/read/24275928/bronchoprovocation-tests-in-asthma-direct-versus-indirect-challenges
#10
REVIEW
Jörg D Leuppi
PURPOSE OF REVIEW: This review describes different bronchoprovocation tests and their merits in diagnosing asthma. RECENT FINDINGS: A new indirect challenge test using dry powder mannitol has been made available and has been systematically validated and tested in different populations. SUMMARY: Airway hyperresponsiveness (AHR) is a characteristic feature of asthma, and its measurement using direct inhalation challenges, particularly with inhaled methacholine or histamine, or indirect challenges using stimuli such as exercise, dry air hyperpnea, distilled water, hypertonic saline and mannitol, and the pharmacological agent adenosine monophosphate is important in establishing a correct diagnosis...
January 2014: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/24245689/are-sputum-eosinophil-cationic-protein-and-eosinophils-differently-associated-with-clinical-and-functional-findings-of-asthma
#11
S Cianchetti, E Bacci, L Ruocco, T Pavia, M L Bartoli, C Cardini, F Costa, A Di Franco, L Malagrinò, F Novelli, B Vagaggini, A Celi, F Dente, P Paggiaro
BACKGROUND: Sputum eosinophil counts and eosinophil cationic protein (ECP) levels are usually increased in asthmatic patients. The correlation between sputum eosinophils or ECP and clinical findings of asthma has been previously investigated but many of these studies have been performed on small samples of asthmatic patients, considering only few clinical indices and often including patients on oral or inhaled corticosteroids, which might be confounding when interpreting the relationship between disease activity and airway inflammation...
2014: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/23632183/inhaled-hypertonic-saline-hyaluronic-acid-in-cystic-fibrosis-with-asthma-like-symptoms-a-new-therapeutic-chance
#12
Federico Cresta, Aldo Naselli, Federica Favilli, Rosaria Casciaro
The aim of the paper is to report the case of a boy affected by cystic fibrosis, with non-ABPA-related recurrent wheezing and frequent pulmonary exacerbation during childhood, who had been  inhaling 7% NaCl+0.1% hyaluronic acid (HA) as a maintenance therapy. We reviewed patient database and, analysing a 7-year follow-up, considered pulmonary exacerbation, antibiotic and steroid courses, pulmonary function (forced expiratory volume in one second; FEV1) and microbiological data. After starting 7% NaCl+0.1% HA treatment, we observed a dramatic decrease of oral antibiotic need (0...
2013: BMJ Case Reports
https://www.readbyqxmd.com/read/23401467/induced-sputum-cell-count-and-cytokine-profile-in-atopic-and-non-atopic-children-with-asthma
#13
G Vizmanos-Lamotte, A Moreno-Galdó, X Muñoz, S Gómez-Ollés, S Gartner, M J Cruz
BACKGROUND AND AIM: Sputum induction is a semi-invasive technique used to detect and monitor airway inflammation. In this study, the cell profile, and Th1 and Th2 cytokine levels in induced sputum of asthmatic and healthy children (HC) are compared. METHODS: Sputum induction was performed in healthy and asthmatic children by inhalation of hypertonic saline solution. Differential cell count in the specimen obtained was carried out using optic microscopy. IFN-γ, IL-2, IL-10, IL-8, IL-6, IL-4, IL-5, IL-1β, TNF-α, and IL-12p70 levels were determined in sputum sample supernatants by flow cytometry...
November 2013: Pediatric Pulmonology
https://www.readbyqxmd.com/read/23145908/investigation-of-the-association-between-dietary-intake-disease-severity-and-airway-inflammation-in-asthma
#14
COMPARATIVE STUDY
Bronwyn S Berthon, Lesley K Macdonald-Wicks, Peter G Gibson, Lisa G Wood
BACKGROUND AND OBJECTIVE: Dietary intake is an important modifiable risk factor for asthma and may be related to disease severity and inflammation, through the effects of intake of anti-oxidant-rich foods and pro-inflammatory nutrients. This study aimed to examine dietary intake in asthma in relation to asthma severity, lung function, inhaled corticosteroid use, leptin levels and inflammation. METHODS: Food frequency questionnaires, spirometry and hypertonic saline challenge were completed by 137 stable asthmatics and 65 healthy controls...
April 2013: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/22247297/assessment-and-prevention-of-exercise-induced-bronchoconstriction
#15
REVIEW
Sandra D Anderson, Pascale Kippelen
The assessment of exercise-induced bronchoconstriction (EIB) in athletes requires the measurement of forced expiratory volume in 1 s (FEV(1)) before and after vigorous exercise or a surrogate of exercise such as eucapnic voluntary hyperpnoea (EVH) of dry air or mannitol dry powder. Exercise testing in a laboratory has a low sensitivity to identify EIB, and exercise testing in the field can be a challenge in itself particularly in cold weather athletes. The EVH test requires the subject to ventilate dry air containing ∼5% CO(2) for 6 min through a low-resistance circuit at a rate higher than that usually achieved on maximum exercise...
May 2012: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/22167396/allergic-bronchopulmonary-aspergillosis-and-related-allergic-syndromes
#16
REVIEW
Celia Hogan, David W Denning
While allergic bronchopulmonary aspergillosis (ABPA) is well recognized as a fungal complication of asthma, severe asthma with fungal sensitization (SAFS) is not. In ABPA the total immunoglobulin E (IgE) is usually >1,000 IU/mL, whereas in SAFS it is <1,000 IU/mL, and either skin prick tests or fungus-specific IgE tests are positive. ABPA may present with any severity of asthma, and occasionally with no asthma or cystic fibrosis, the other common underlying disease. SAFS is a problem in patients with poorly controlled asthma and occasionally presents in the intensive care unit (ICU)...
December 2011: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/22135379/bile-acids-in-sputum-and-increased-airway-inflammation-in-patients-with-cystic-fibrosis
#17
Ans Pauwels, Ann Decraene, Kathleen Blondeau, Veerle Mertens, Ricard Farre, Marijke Proesmans, Pascal Van Bleyenbergh, Daniel Sifrim, Lieven J Dupont
BACKGROUND: Up to 80% of patients with cystic fibrosis (CF) may have increased gastroesophageal reflux and aspiration of duodenogastric contents into the lungs. We aimed to assess aspiration in patients with CF by measuring duodenogastric components in induced sputum and to investigate whether the presence of bile acids (BAs) in sputum was correlated with disease severity and markers of inflammation. METHODS: In 41 patients with CF, 15 healthy volunteers, 29 patients with asthma, and 28 patients with chronic cough, sputum was obtained after inhalation of hypertonic saline...
June 2012: Chest
https://www.readbyqxmd.com/read/21999754/cough-response-to-isocapnic-hyperpnoea-of-dry-air-and-hypertonic-saline-are-interrelated
#18
Minna Purokivi, Heikki Koskela, John D Brannan, Kirsi Kontra
BACKGROUND: Mechanisms behind asthmatic cough are largely unknown. It is known that hyperosmolar challenges provoke cough in asthmatic but not in the healthy subjects. It has been postulated that isocapnic hyperpnea of dry air (IHDA) and hypertonic aerosols act via similar mechanisms in asthma to cause bronchoconstriction. We investigated whether there is an association between cough response induced by IHDA and hypertonic saline (HS) challenges. METHODS: Thirty-six asthmatic and 14 healthy subjects inhaled HS solutions with increasing osmolalities administered via ultrasonic nebuliser until 15 cumulative coughs were recorded...
2011: Cough
https://www.readbyqxmd.com/read/21790924/can-we-predict-sputum-eosinophilia-from-clinical-assessment-in-patients-referred-to-an-adult-asthma-clinic
#19
E Yap, W M Chua, L Jayaram, I Zeng, A C Vandal, J Garrett
BACKGROUND: There is overwhelming evidence that asthma guidelines aimed at reducing airway inflammation are superior to those based on clinical symptoms alone. This involves targeting eosinophilic inflammation with inhaled corticosteroids. AIM: Because induced sputum is not readily available, our study set out to investigate whether the collective or singular use of routine asthma investigations can predict sputum eosinophilia. METHODS: Eighty patients underwent skin prick testing, blood tests (IgE, full blood count), spirometry, exhaled fraction nitric oxide (FeNO), PD15 to hypertonic saline, and induced sputum testing at first assessment...
January 2013: Internal Medicine Journal
https://www.readbyqxmd.com/read/21190152/-exercise-induced-bronchoconstriction
#20
REVIEW
Katarzyna Hildebrand
Terms exercise-induced asthma (EIA) or exercise-induced bronchoconstriction (EIB) are used to describe transient bronchoconstriction occurring during or immediately after vigorous exercise in some subjects. For the diagnosis of EIB it is necessary to show at least 10% decrease in FEV1 from baseline following physical exercise. The prevalence of EIB has been reported to be 12-15% in general population, 10-20% in summer olympic athletes, affecting up to 50-70% of winter athletes (particularly ski runners and skaters)...
2011: Pneumonologia i Alergologia Polska
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