keyword
https://read.qxmd.com/read/37172929/modulation-of-pulmonary-blood-flow-in-patients-with-acute-respiratory-failure
#21
JOURNAL ARTICLE
Stefano Spina, Francesco Marrazzo, Caio C A Morais, Marcus Victor, Clarissa Forlini, Marcello Guarnieri, Luca Bastia, Riccardo Giudici, Gabriele Bassi, Yi Xin, Maurizio Cereda, Marcelo Amato, Thomas Langer, Lorenzo Berra, Roberto Fumagalli
BACKGROUND: Impairment of ventilation and perfusion (V/Q) matching is a common mechanism leading to hypoxemia in patients with acute respiratory failure requiring intensive care unit (ICU) admission. While ventilation has been thoroughly investigated, little progress has been made to monitor pulmonary perfusion at the bedside and treat impaired blood distribution. The study aimed to assess real-time changes in regional pulmonary perfusion in response to a therapeutic intervention. METHODS: Single-center prospective study that enrolled adult patients with ARDS caused by SARS-Cov-2 who were sedated, paralyzed, and mechanically ventilated...
July 1, 2023: Nitric Oxide: Biology and Chemistry
https://read.qxmd.com/read/37138709/successful-blood-transfusion-in-a-holstein-cow-experiencing-hemorrhagic-shock-under-general-anesthesia
#22
Megan E Mackintosh, Frédérik Rousseau-Blass, Jessica M Pang, Daniel S J Pang
A 2-year-old Holstein cow weighing 530 kg at 2 mo gestation was scheduled for a paracostal laparotomy and abomasotomy following diagnosis of a reticular foreign body causing obstruction and abomasal impaction. Hemorrhagic shock occurred during surgery, with a rapid, approximately 60% decrease in arterial blood pressure, and reflex tachycardia with a 2-fold increase in heart rate. Following identification of hemorrhagic shock, arterial blood pressure was supported by reducing the inhalant anesthetic requirement, positive inotropic support (IV dobutamine infusion), and IV fluid therapy...
May 2023: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/37082471/acute-viral-bronchiolitis-a-narrative-review
#23
REVIEW
Suresh K Angurana, Vijai Williams, Lalit Takia
Acute viral bronchiolitis (AVB) is the leading cause of hospital admissions among infants in developed and developing countries and associated with increased morbidity and cost of treatment. This review was performed to guide the clinicians managing AVB in light of evidence accumulated in the last decade. We searched published English literature in last decade regarding etiology, diagnosis, treatment, and prevention of AVB using PubMed and Cochrane Database of Systematic Reviews. Respiratory syncytial virus is the most common causative agent...
June 2023: Journal of Pediatric Intensive Care
https://read.qxmd.com/read/36990700/-chinese-experts-consensus-statement-diagnosis-and-treatment-of-cystic-fibrosis-2023
#24
JOURNAL ARTICLE
(no author information available yet)
Cystic fibrosis (CF) is one of the most common autosomal recessive genetic diseases in Caucasians, but CF patients in China are rare, and it was listed as the first batch of rare diseases in China in 2018. In recent years, CF has been gradually recognized in China, and the number of CF patients reported in China in the past 10 years is more than 2.5 times the total number in the previous 30 years, and the total number of CF patients is estimated to be more than 20 000. The research progress of CF gene modification has led to the innovation of CF treatment...
April 12, 2023: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/36988679/twenty-one-year-follow-up-revealed-guideline-concordant-and-non-concordant-trends-in-intensive-care-of-bronchiolitis
#25
JOURNAL ARTICLE
Sofia Selin, Minna Mecklin, Matti Korppi, Paula Heikkilä
UNLABELLED: To evaluate the management of bronchiolitis in the paediatric intensive care unit (PICU) before and after publication of the national bronchiolitis guidelines in June 2015. All infants treated between 2016-2020 for bronchiolitis in the PICU of Tampere University Hospital at < 12 months of age were included. The data were retrospectively collected from electronic patient records. The current results reflecting the post-guideline era were compared with previously published results for the pre-guideline 2000-2015 period...
March 29, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/36723457/use-of-dornase-alfa-in-pediatric-patients-without-cystic-fibrosis
#26
JOURNAL ARTICLE
Krishna C Daiya, Caroline M Sierra
OBJECTIVES: Literature regarding clinical benefits of dornase alfa (DNase) in pediatric patients without cystic fibrosis is lacking. In December 2020, the study institution implemented restrictions to limit DNase use in this patient population. The primary objective was adherence to DNase ordering restrictions. Secondary objectives included length of stay, respiratory function, and use of inhaled mucolytic agents. METHODS: This single-center retrospective chart review included patients less than 18 years of age who received DNase one year prior to through one year after order restriction implementation...
February 1, 2023: Hospital Practice (Minneapolis)
https://read.qxmd.com/read/36711047/efficacy-of-hypertonic-saline-versus-isotonic-saline-among-children-with-cystic-fibrosis-a-systematic-review-and-meta-analysis
#27
REVIEW
Saad Ehsan Ullah, Mohammad Munim Zahoor, Swatika Gupta, Sukhman Boparai, Muhammad Muneeb, Shahda A H Eltieb, Abhirami Shankar, Harriet Mmaitsi Kidiavai, Rimsha Rahim Vohra, Anjuli Devi, Zainab Asif Bhura, Zaid Muhammad Aslam, Mudassir Shoaib
BACKGROUND: Inhaled hypertonic saline (HS) reduces pulmonary exacerbations in patients with cystic fibrosis (CF) aged 6 or more years. However, the effectiveness of HS in improving clinical outcomes in younger children aged 6 or less years is not established. This study examines the efficacy of HS in younger CF patients. METHODS: Searches were conducted across three databases (Medline, Cochrane Central and EMBASE) from inception through July 2022. Randomized controlled trials assessing the impact of HS in younger CF patients were included...
2023: Canadian Journal of Respiratory Therapy: CJRT
https://read.qxmd.com/read/36655223/nasal-epithelial-cell-culture-fluorescence-recovery-after-photobleaching-predicts-cystic-fibrosis-therapeutic-response
#28
JOURNAL ARTICLE
Timothy E Corcoran, Carol A Bertrand, Michael M Myerburg, Daniel J Weiner, Sheila A Frizzell, Anna Li, Brittani Agostini, Robert S Parker, Monica E Shapiro, Ashok Muthukrishnan, Nicholas D Hages, Brian P Mulhern, Joseph M Pilewski
BACKGROUND: Human nasal epithelial (HNE) cells can be sampled noninvasively and cultured to provide a model of the airway epithelium that reflects cystic fibrosis (CF) pathophysiology. We hypothesised that in vitro measures of HNE cell physiology would correlate directly with in vivo measures of lung physiology and therapeutic response, providing a framework for using HNE cells for therapeutic development and precision medicine. METHODS: We sampled nasal cells from participants with CF (CF group, n=26), healthy controls (HC group, n=14) and single CF transmembrane conductance regulator (CFTR) mutation carrier parents of the CF group (CR group, n=16)...
October 2022: ERJ Open Research
https://read.qxmd.com/read/36553266/clinical-course-of-children-with-chronic-suppurative-lung-disease-or-bronchiectasis-infected-with-pseudomonas-aeruginosa
#29
JOURNAL ARTICLE
Elpiniki Kartsiouni, Stylianos Chatzipanagiotou, Angeliki Galani, Dafni Moriki, Olympia Sardeli, Spyridon Prountzos, Efthymia Alexopoulou, Ioanna Loukou, Kostas N Priftis, Konstantinos Douros
Children with chronic wet cough and without cystic fibrosis (non-CF) may suffer from chronic suppurative lung disease (CSLD) or bronchiectasis. Pseudomonas aeruginosa (Pa) can be one of the offending microbes in these children. The present study aimed to describe the clinical course of children with the above two conditions who were infected with Pa. Data of 54 children with CSLD/bronchiectasis who were diagnosed and attended in our department were retrospectively analysed through a Cox proportional hazard model, with age, presence of bronchiectasis, use of inhaled colistin, azithromycin, inhaled hypertonic saline as the covariates...
November 25, 2022: Children
https://read.qxmd.com/read/36479308/the-differences-between-rsv-and-no-rsv-acute-bronchiolitis-in-hospitalized-infants-a-cross-sectional-study
#30
JOURNAL ARTICLE
Evangelos Christou, Evangelos Bourousis, Avraam Pouliakis, Konstantinos Douros, Pinelopi Varela, Dimitris Delis, Kostas N Priftis
To identify the differences between the RSV and non-RSV bronchiolitis in hospitalized infants in a Greek tertiary pediatric unit and the possible risk factors related to severe forms of the illness. We performed a retrospective cross-sectional data analysis by reviewing medical records of patients that were hospitalized for acute bronchiolitis from 2012 to 2019. The patients with RSV bronchiolitis were found to require antibiotic treatment, IV fluids, adrenaline, and hypertonic saline inhalations more frequently than the non-RSV patients...
2022: Global Pediatric Health
https://read.qxmd.com/read/36414591/long-term-use-of-inhaled-hypertonic-saline-in-children-and-adolescents-with-cystic-fibrosis-experience-from-a-tertiary-care-center-in-a-low-and-middle-income-country
#31
JOURNAL ARTICLE
Danish Abdul Aziz, Shahira Shahid, Anusha Alam, Namrah Aziz, Fatima Mir
BACKGROUND: Long term hypertonic saline use has been found to improve mucus transport, airway hydration, and mucociliary clearance in patients with cystic fibrosis. However, the effect of hypertonic saline on the outcomes of patients with cystic fibrosis is not well established. The aim of our study was to determine the long-term use of hypertonic saline in reducing pulmonary exacerbations, length of hospital stay and pseudomonas colonization in patients with cystic fibrosis admitted for treatment at a tertiary care referral center...
2022: Journal of Ayub Medical College, Abbottabad: JAMC
https://read.qxmd.com/read/36260509/preliminary-investigation-of-a-hypertonic-saline-nasal-rinse-as-a-hygienic-intervention-in-dairy-workers
#32
JOURNAL ARTICLE
Grant Erlandson, Sheryl Magzamen, Julia L Sharp, Sanchayita Mitra, Kenneth Jones, Jill A Poole, Mary Bradford, Matthew Nonnenmann, Stephen J Reynolds, Joshua W Schaeffer
Livestock workers experience an increased burden of bioaerosol-induced respiratory disease including high prevalence of rhinosinusitis. Dairy operations generate bioaerosols spanning the inhalable size fraction (0-100 μm) containing bacterial constituents such as endotoxin. Particles with an aerodynamic diameter between 10-100 μm are known to deposit in the nasopharyngeal region and likely affect the upper respiratory tract. We evaluated the effectiveness of a hypertonic saline nasal lavage in reducing inflammatory responses in dairy workers from a high-volume dairy operation...
October 19, 2022: Journal of Occupational and Environmental Hygiene
https://read.qxmd.com/read/36073059/tromethamine-improves-mucociliary-clearance-in-cystic-fibrosis-pigs
#33
JOURNAL ARTICLE
Jamison J Ash, Brieanna M Hilkin, Nicholas D Gansemer, Eric A Hoffman, Joseph Zabner, David A Stoltz, Mahmoud H Abou Alaiwa
In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated Cl-  and HCO3 -  secretion across the epithelium acidifies the airway surface liquid (ASL). Acidic ASL alters two key host defense mechanisms: Rapid ASL bacterial killing and mucociliary transport (MCT). Aerosolized tromethamine (Tham) increases ASL pH and restores the ability of ASL to rapidly kill bacteria in CF pigs. In CF pigs, clearance of insufflated microdisks is interrupted due to abnormal mucus causing microdisks to abruptly recoil...
September 2022: Physiological Reports
https://read.qxmd.com/read/35927765/dornase-alfa-in-cystic-fibrosis-indications-comparative-studies-and-effects-on-lung-clearance-index
#34
REVIEW
Vito Terlizzi, Chiara Castellani, Giovanni Taccetti, Beatrice Ferrari
Cystic fibrosis (CF) is the most common inherited disease in Caucasian populations, affecting around 50,000 patients in Europe and 30,000 in United States. A mutation in CF trans-membrane conductance regulator (CFTR) gene changes a protein (a regulated chloride channel), which is expressed in many tissues. Defective CFTR results in reduced chloride secretion and an overage absorption of sodium across the epithelia, leading to thickened secretions in organs such as pancreas and lung. Gradually, there have been considerable improvements in the survival of people with CF, thanks to substantial changes in specialized CF care and the discovery of new CFTR modulators drugs...
August 4, 2022: Italian Journal of Pediatrics
https://read.qxmd.com/read/35903281/trends-in-growth-and-maturation-in-children-with-cystic-fibrosis-throughout-nine-decades
#35
REVIEW
Kelly A Mason, Alan D Rogol
Since cystic fibrosis (CF) was first described in 1938, there have been many discoveries and innovations in the field, each having a profound impact on survival, growth and quality of life. For example, the introduction of enteric-coated pancreatic enzyme microspheres increased fat absorption and improved nutritional status. Early detection of CF through newborn screening facilitated prompt nutritional intervention for infants at high risk of malnutrition. Use of anti-pseudomonal therapy, such as inhaled tobramycin, increased weight gain and pulmonary function in addition to reducing pulmonary exacerbations...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/35486871/cystic-fibrosis-airway-mucus-hyperconcentration-produces-a-vicious-cycle-of-mucin-pathogen-and-inflammatory-interactions-that-promote-disease-persistence
#36
JOURNAL ARTICLE
Bethany Batson, Bryan Zorn, Giorgia Radicioni, Stephanie Livengood, Tadahiro Kumagai, Hong Dang, Agathe Ceppe, Phillip Clapp, Michael Tunney, Stuart Elborn, Gerry McElvaney, Marianne Muhlebach, Richard C Boucher, Michael Tiemeyer, Matthew Wolfgang, Mehmet Kesimer
The dynamics describing the vicious cycle characteristic of CF lung disease, initiated by stagnant mucus and perpetuated by infection and inflammation, remain unclear. Here we determine the effect of the CF airway milieu, with persistent muco-obstruction, resident pathogens, and inflammation, on the mucin quantity/quality that govern lung disease pathogenesis/progression. The concentrations of MUC5AC and MUC5B, were measured and characterized in sputum samples from CF (N=44) and healthy (N=29) subjects with respect to their macromolecular properties, degree of proteolysis, and glycomics diversity...
April 29, 2022: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/35307053/-international-clinical-research-of-critical-care-medicine-in-2021
#37
JOURNAL ARTICLE
Qingdong Li, Ziqi Rong, Pengyu Lu, Wei Huang
The progress of critical care medicine in 2021 is still encouraging. The new international guideline for management of sepsis and septic shock came out after 4 years. Besides, a couple of preferable clinical evidences were released including restrictive blood transfusion strategy for patients with acute myocardial infarction, prevention of peripheral venous catheter infection, heparin inhalation and driving pressure setting in patients with acute respiratory distress syndrome (ARDS), lower oxygenation target for acute hypoxemic respiratory failure, low level positive end-expiratory pressure in non-ARDS patients with respiratory failure, light sedation or non-sedation strategy, biological phenotypes, as well machine learning in sepsis and ARDS...
January 2022: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/35110073/inhaled-pharmacotherapy-for-neonates-a-narrative-review
#38
JOURNAL ARTICLE
Gustavo Rocha
The inhaled route for drug administration in neonates offers several advantages over the systemic routes, since it delivers medications directly to the diseased organ, enabling higher doses locally with less systemic toxicity. Respiratory drugs can be administered in both ventilated and non-ventilated term and preterm infants. This review was carried out using selected literature, with a focus on the most used inhaled pharmacological agents in neonatal care, summarizing, with levels of evidence (LoE), their indications, doses, administration schedules, and main adverse effects...
January 2022: Turkish archives of pediatrics
https://read.qxmd.com/read/35103070/nursing-progress-of-hypertonic-saline-inhalation-in-the-treatment-of-infantile-bronchitis-based-on-image-enhancement
#39
JOURNAL ARTICLE
Haiyan Li, Yangang Song, Xue Chen, Hesheng Sun
The onset of bronchiolitis is closely related to the anatomical characteristics of the bronchi in children of this age. This kind of injury is caused by epithelial necrosis, nasal mucosa, and mucosal edema caused by narrowing and blockage of the trachea. Children with this serious phenomenon will have respiratory and heart failure, which threatens the life of children to a large extent. In this paper, based on image enhancement technology, hypertonic saline aerosol inhalation treatment of pediatric bronchiolitis nursing care, through related cases, the application of image enhancement technology in hypertonic saline aerosol inhalation therapy and pediatric bronchiolitis is analyzed, and the tone mapping function is used...
2022: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/35102722/the-success-of-the-cystic-fibrosis-registry-of-turkey-for-improvement-of-patient-care
#40
JOURNAL ARTICLE
Pelin Asfuroglu, Tugba Sismanlar Eyuboglu, Ayse Tana Aslan, Tugba Ramasli Gursoy, Nagehan Emiralioglu, Ebru Yalcin, Nural Kiper, Velat Sen, Hadice Selimoglu Sen, Derya Ufuk Altintas, Dilek Ozcan, Ayse Ayzit Kilinc, Haluk Cokugras, Azer Kilic Baskan, Hakan Yazan, Ufuk Erenberk, Guzide Dogan, Gokcen Unal, Asli Imran Yilmaz, Ozlem Keskin, Elif Arik, Ercan Kucukosmanoglu, Ilim Irmak, Ebru Damadoglu, Gokcen Kartal Ozturk, Figen Gulen, Abdurrahman Erdem Basaran, Aysen Bingol, Sukru Cekic, Nihat Sapan, Gonca Kilic, Koray Harmanci, Mehmet Kose, Ali Ozdemir, Gokcen Dilsa Tugcu, Sanem Eryilmaz Polat, Melih Hangul, Gizem Ozcan, Zeynep Gokce Gayretli Aydin, Hasan Yuksel, Erdem Topal, Sebnem Ozdogan, Gonul Caltepe, Ayse Suleyman, Demet Can, Pervin Korkmaz Ekren, Cem Murat Bal, Mehmet Kilic, Guzin Cinel, Nazan Cobanoglu, Sevgi Pekcan, Erkan Cakir, Ugur Ozcelik, Deniz Dogru
BACKGROUND: Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association of newly established CF registry system in Turkey on follow-up, clinical, growth, treatment, and complications of people with this disease. METHODS: Age at diagnosis, current age, sex, z-scores of weight, height and body mass index (BMI), neonatal screening results, pulmonary function tests, history of meconium ileus, medications, presence of microorganisms, and follow-up were evaluated and compared to data of people with CF represented in both 2017 and 2019 registry data...
May 2022: Pediatric Pulmonology
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