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https://www.readbyqxmd.com/read/27624002/allergy-specific-phenome-wide-association-study-for-immunogenes-in-turkish-children
#1
Sefayet Karaca, Ersoy Civelek, Mehmet Karaca, Umit M Sahiner, Riza K Ozgul, Can N Kocabas, Renato Polimanti, Bülent E Sekerel
To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted using ISAAC (International Study of Asthma and Allergies in Children) Phase II tools. We investigated 9 loci involved in different immune functions (ADAM33, ADRB2, CD14, IL13, IL4, IL4R, MS4A2, SERPINE1, and TNF) with respect to 116 traits assessed through blood tests, hypertonic saline challenge tests, questionnaires, and skin prick tests...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27563742/the-advantages-of-adding-hyaluronic-acid-or-mannitol-to-hypertonic-saline-inhalation-treatment-in-cystic-fibrosis
#2
Clizia Cazzarolli, Chiara Tartali, Ugo Pradal
No abstract text is available yet for this article.
August 26, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27492520/stepping-down-from-combination-asthma-therapy-the-predictors-of-outcome
#3
Heikki O Koskela, Minna K Purokivi, Jouko Kokkarinen
BACKGROUND: Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start stepping down more often than previously. METHODS: In 55 subjects with well controlled asthma and combination therapy, LABAs were discontinued first, followed by ICS dose halving, and then cessation, in six weeks' intervals...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27393775/chronic-rhinosinusitis-in-patients-with-cystic-fibrosis
#4
Daniel L Hamilos
Chronic rhinosinusitis (CRS) is highly prevalent in patients with cystic fibrosis (CF) and accounts for significant morbidity and contribution to CF lung disease. Mutations of the cystic fibrosis transmembrane regulator gene occur with increased prevalence in patients with CRS without CF, suggesting some contribution to CRS pathophysiology. Nasal polyps (NPs) occur with increased prevalence in patients with CF of all ages and have a more neutrophilic appearance with fewer eosinophils and increased submucosal glandular elements in comparison to NPs from patients without CF...
July 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27390778/repurposing-tromethamine-as-inhaled-therapy-to-treat-cf-airway-disease
#5
Mahmoud H Abou Alaiwa, Janice L Launspach, Kelsey A Sheets, Jade A Rivera, Nicholas D Gansemer, Peter J Taft, Peter S Thorne, Michael J Welsh, David A Stoltz, Joseph Zabner
In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR) anion channel activity causes airway surface liquid (ASL) pH to become acidic, which impairs airway host defenses. One potential therapeutic approach is to correct the acidic pH in CF airways by aerosolizing HCO3 (-) and/or nonbicarbonate pH buffers. Here, we show that raising ASL pH with inhaled HCO3 (-) increased pH. However, the effect was transient, and pH returned to baseline values within 30 minutes. Tromethamine (Tham) is a buffer with a long serum half-life used as an i...
June 2, 2016: JCI Insight
https://www.readbyqxmd.com/read/27303780/acute-viral-bronchiolitis-in-south-africa-strategies-for-management-and-prevention
#6
H J Zar, S A Madhi, D A White, R Masekela, S Risenga, H Lewis, C Feldman, B Morrow, P Jeena
Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, rapid short-acting bronchodilators, adrenaline or ipratropium bromide for children with acute viral bronchiolitis. Likewise, there is no demonstrated benefit from routine use of inhaled or oral corticosteroids, inhaled hypertonic saline nebulisation, montelukast or antibiotics. The last should be reserved for children with severe disease, when bacterial co-infection is suspected...
April 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27267518/sino-nasal-inhalation-of-isotonic-versus-hypertonic-saline-6-0-in-cf-patients-with-chronic-rhinosinusitis-results-of-a-multicenter-prospective-randomized-double-blind-controlled-trial
#7
Jochen G Mainz, Ulrike Schumacher, Katja Schädlich, Julia Hentschel, Christiane Koitschev, Assen Koitschev, Joachim Riethmüller, Freerk Prenzel, Olaf Sommerburg, Bärbel Wiedemann, Doris Staab, Wolfgang Gleiber, Rainald Fischer, James F Beck, Christin Arnold
BACKGROUND: Chronic rhinosinusitis is a hallmark of Cystic fibrosis (CF) impairing the patients' quality of life and overall health. However, therapeutic options have not been sufficiently evaluated. Bronchial inhalation of mucolytic substances is a gold standard in CF therapy. Previously, we found that sinonasal inhalation of dornase alfa as vibrating aerosol reduces symptoms of chronic rhinosinusitis more effectively than NaCl 0.9% (net treatment benefit: -5.87±2.3 points, p=0.017; SNOT-20 total score)...
June 4, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/27177013/a-regional-cohort-study-of-the-treatment-of-critically-ill-children-with-bronchiolitis
#8
Christopher L Carroll, Edward Vincent S Faustino, Matthew G Pinto, Kathleen A Sala, Michael F Canarie, Simon Li, John S Giuliano, The Northeast Pediatric Critical Care Research Consortium
OBJECTIVE: To describe the treatment practices in critically ill children with RSV bronchiolitis across four regional PICUs in the northeastern United States, and to determine the factors associated with increased ICU length of stay in this population. METHODS: We conducted a retrospective cohort study of children who were admitted with RSV bronchiolitis between July 2009 and July 2011 to the PICUs of Connecticut Children's Medical Center, Yale-New Haven Children's Hospital, Maria Fareri Children's Hospital, and Baystate Children's Hospital...
December 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27149365/pilot-randomized-controlled-trial-evaluating-the-effect-of-hypertonic-saline-with-and-without-hyaluronic-acid-in-reducing-inflammation-in-cystic-fibrosis
#9
Anna Brivio, Massimo Conese, Simone Gambazza, Arianna Biffi, Amedea Silvia Tirelli, Maria Russo, Michaela Foà, Carla Colombo
BACKGROUND: Hypertonic saline (HS) has been established as a therapy aimed at restoring the surface liquid of airways liquid and enhancing mucociliary clearance in patients with cystic fibrosis (CF). A formula containing 7% HS and 0.1% hyaluronic acid (HA) is also available, basing its use on the protective effects of HA against elastin injury and on its greater ease of administration (i.e., the perceived acceptability of inhalation). This study explores the effect of HA+HS in reducing the inflammation of airways, by measuring cytokine levels in sputum, its safety profile, and the prevalence of commonly reported symptoms like cough, throat irritation, and saltiness...
December 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27111485/nebulised-hypertonic-saline-inhalations-do-not-shorten-hospital-stays-in-infants-with-bronchiolitis
#10
Paula Heikkilä, Matti Korppi
No abstract text is available yet for this article.
September 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26997926/hypertonic-saline-for-the-treatment-of-bronchiolitis-in-infants-and-young-children-a-critical-review-of-the-literature
#11
REVIEW
Jeffrey Baron, Gladys El-Chaar
Bronchiolitis, an infection of the lower respiratory tract, is the leading cause of infant and child hospitalization in the United States. Therapeutic options for management of bronchiolitis are limited. Hypertonic saline inhalation therapy has been studied in numerous clinical trials with mixed results. In 2014, the American Academy of Pediatrics (AAP) published updated guidelines on the diagnosis and management of bronchiolitis, which include new recommendations on the use of hypertonic saline. We reviewed all published clinical trials mentioned in the 2014 AAP guidelines, as well as additional trials published since the guidelines, and critically evaluated each trial to determine efficacy, safety, and expectations of hypertonic saline inhalation therapy...
January 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/26908255/-indirect-challenges-from-science-to-clinical-practice
#12
REVIEW
Sandra D Anderson
Indirect challenges act to provoke bronchoconstriction by causing the release of endogenous mediators and are used to identify airway hyper-responsiveness. This paper reviews the historical development of challenges, with exercise, eucapnic voluntary hyperpnoea (EVH) of dry air, wet hypertonic saline, and with dry powder mannitol, that preceded their use in clinical practice. The first challenge developed for clinical use was exercise. Physicians were keen for a standardized test to identify exercise-induced asthma (EIA) and to assess the effect of drugs such as disodium cromoglycate...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26856191/a-randomized-controlled-trial-to-evaluate-the-lung-clearance-index-as-an-outcome-measure-for-early-phase-studies-in-patients-with-cystic-fibrosis
#13
RANDOMIZED CONTROLLED TRIAL
Reshma Amin, Sanja Stanojevic, Mica Kane, Hailey Webster, Felix Ratjen
BACKGROUND: Outcome measures that can evaluate treatment efficacy are important to enhance development of new therapeutic agents for Cystic Fibrosis (CF). We investigated whether the lung clearance index (LCI) measured by multiple breath washout (MBW) can detect a treatment effect of hypertonic saline (HS) inhalation after single dosing within a 24 h period. METHODS: In this randomized controlled cross-over trial, CF patients received inhalation of HS and isotonic saline (IS)...
March 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/26769016/a-randomised-trial-of-hypertonic-saline-during-hospitalisation-for-exacerbation-of-cystic-fibrosis
#14
RANDOMIZED CONTROLLED TRIAL
Ruth L Dentice, Mark R Elkins, Peter G Middleton, Jennifer R Bishop, Peter A B Wark, Douglas J Dorahy, Christopher J Harmer, Honghua Hu, Peter T P Bye
BACKGROUND: The mucoactive effects of hypertonic saline should promote exacerbation resolution in people with cystic fibrosis (CF). OBJECTIVES: To determine the effects of hypertonic saline inhalation during hospitalisation for exacerbation of CF on length of stay, lung function, symptoms, oxygenation, exercise tolerance, quality of life, bacterial load and time to next hospitalisation. METHODS: 132 adults with an exacerbation of CF were randomised to inhale three nebulised doses a day of either 4 mL 7% saline or a taste-masked control of 0...
February 2016: Thorax
https://www.readbyqxmd.com/read/26749716/-cystic-fibrosis-care-of-the-lung-disease
#15
Dominique Hubert
(Rh-DNase) and/or hydration (hypertonic saline) nebulisations, Moreover, treatment with inhaled antibiotics is indicated (tobramycin, colistine or aztreonam lysine) for chronic lung infection with Pseudomonas aeruginosa (PA). The treatment regimen also includes bronchodilators for bronchospasms and azithromycin. Regular physical activity is recommended. A treatment potentiating the CFTR protein, ivacaftor, is now indicated for patients with a class 3 mutation. Initial bronchial infection with PA must be treated as soon as possible in order to eradicate the pathogen...
October 2015: La Revue du Praticien
https://www.readbyqxmd.com/read/26741301/the-influence-of-nebulized-drugs-on-nasal-ciliary-activity
#16
Mieke Boon, Mark Jorissen, Martine Jaspers, Patrick Augustijns, François L Vermeulen, Marijke Proesmans, Kris De Boeck
INTRODUCTION: Nebulized drugs are used in the treatment of cystic fibrosis (CF) lung disease, asthma, and COPD, and increasingly also in other chronic lung diseases. Their use in CF is reasonably evidence based, but this is not so for use in other orphan diseases. Potential side effects often have not been studied. Therefore, we evaluated the influence of nebulized drugs on ciliary activity in an in vitro model. METHODS: We constructed an in vitro nebulization model to examine the effect of drugs on ciliary activity...
August 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/26553190/3-hypertonic-saline-versus-normal-saline-in-inpatient-bronchiolitis-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Alyssa H Silver, Nora Esteban-Cruciani, Gabriella Azzarone, Lindsey C Douglas, Diana S Lee, Sheila Liewehr, Joanne M Nazif, Ilir Agalliu, Susan Villegas, Hai Jung H Rhim, Michael L Rinke, Katherine O'Connor
BACKGROUND AND OBJECTIVES: Bronchiolitis, the most common reason for hospitalization in children younger than 1 year in the United States, has no proven therapies effective beyond supportive care. We aimed to investigate the effect of nebulized 3% hypertonic saline (HS) compared with nebulized normal saline (NS) on length of stay (LOS) in infants hospitalized with bronchiolitis. METHODS: We conducted a prospective, randomized, double-blind, controlled trial in an urban tertiary care children's hospital in 227 infants younger than 12 months old admitted with a diagnosis of bronchiolitis (190 completed the study); 113 infants were randomized to HS (93 completed the study), and 114 to NS (97 completed the study)...
December 2015: Pediatrics
https://www.readbyqxmd.com/read/26451533/inhaled-mannitol-for-cystic-fibrosis
#18
REVIEW
Sarah J Nolan, Judith Thornton, Clare S Murray, Tiffany Dwyer
BACKGROUND: Several agents are used to clear secretions from the airways of people with cystic fibrosis. Inhaled dry powder mannitol is now available in Australia and some countries in Europe. The exact mechanism of action of mannitol is unknown, but it increases mucociliary clearance. Phase III trials of inhaled dry powder mannitol for the treatment of cystic fibrosis have been completed. The dry powder formulation of mannitol may be more convenient and easier to use compared with established agents which require delivery via a nebuliser...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26416925/nebulized-hypertonic-saline-for-acute-bronchiolitis-a-systematic-review
#19
REVIEW
Linjie Zhang, Raúl A Mendoza-Sassi, Terry P Klassen, Claire Wainwright
BACKGROUND AND OBJECTIVE: The mainstay of treatment for acute bronchiolitis remains supportive care. The objective of this study was to assess the efficacy and safety of nebulized hypertonic saline (HS) in infants with acute bronchiolitis. METHODS: Data sources included PubMed and the Virtual Health Library of the Latin American and Caribbean Center on Health Sciences Information up to May 2015. Studies selected were randomized or quasi-randomized controlled trials comparing nebulized HS with 0...
October 2015: Pediatrics
https://www.readbyqxmd.com/read/26406428/early-in-theater-management-of-combat-related-traumatic-brain-injury-a-prospective-observational-study-to-identify-opportunities-for-performance-improvement
#20
Raymond Fang, Manjunath Markandaya, Joseph J DuBose, Leopoldo C Cancio, Stacy Shackelford, Lorne H Blackbourne
BACKGROUND: Combat-related moderate-to-severe traumatic brain injury (CRTBI) is a significant cause of wartime morbidity and mortality. As of August 2014, moderate-to-severe traumatic brain injuries sustained by members of the Department of Defense worldwide since 2000 totaled 32,996 cases. Previously published epidemiologic reviews describe CRTBI management at a "strategic" level, but they lack "tactical" patient-specific data required for performance improvement. In addition, scarce data exist regarding prehospital CRTBI care...
October 2015: Journal of Trauma and Acute Care Surgery
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