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https://www.readbyqxmd.com/read/28096123/current-evidence-on-the-association-of-dietary-patterns-and-bone-health-a-scoping-review
#1
REVIEW
Elham Z Movassagh, Hassan Vatanparast
Nutrition is an important modifiable factor that affects bone health. Diet is a complex mixture of nutrients and foods that correlate or interact with each other. Dietary pattern approaches take into account contributions from various aspects of diet. Findings from dietary pattern studies could complement those from single-nutrient and food studies on bone health. In this study we aimed to conduct a scoping review of the literature that assessed the impact of dietary patterns (derived with the use of both a priori and data-driven approaches) on bone outcomes, including bone mineral status, bone biomarkers, osteoporosis, and fracture risk...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28094081/emerging-human-fetuin-a-assays-for-biomedical-diagnostics
#2
REVIEW
Sandeep Kumar Vashist, E Marion Schneider, A G Venkatesh, John H T Luong
Human fetuin A (HFA) plays a prominent pathophysiological role in numerous diseases and pathophysiological conditions with considerable biomedical significance; one example is the formation of calciprotein particles in osteoporosis and impaired calcium metabolisms. With impressive advances in in vitro diagnostic assays during the last decade, ELISAs have become a workhorse in routine clinical diagnostics. Recent diagnostic formats involve high-sensitivity immunoassay procedures, surface plasmon resonance, rapid immunoassay chemistries, signal enhancement, and smartphone detection...
January 13, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28093732/long-term-hormone-therapy-for-perimenopausal-and-postmenopausal-women
#3
REVIEW
Jane Marjoribanks, Cindy Farquhar, Helen Roberts, Anne Lethaby, Jasmine Lee
BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a Cochrane review first published in 2005. OBJECTIVES: To assess effects of long-term HT (at least 1 year's duration) on mortality, cardiovascular outcomes, cancer, gallbladder disease, fracture and cognition in perimenopausal and postmenopausal women during and after cessation of treatment...
January 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28090446/quantitative-imaging-methods-in-osteoporosis
#4
REVIEW
Ling Oei, Fjorda Koromani, Fernando Rivadeneira, M Carola Zillikens, Edwin H G Oei
Osteoporosis is characterized by a decreased bone mass and quality resulting in an increased fracture risk. Quantitative imaging methods are critical in the diagnosis and follow-up of treatment effects in osteoporosis. Prior radiographic vertebral fractures and bone mineral density (BMD) as a quantitative parameter derived from dual-energy X-ray absorptiometry (DXA) are among the strongest known predictors of future osteoporotic fractures. Therefore, current clinical decision making relies heavily on accurate assessment of these imaging features...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28089422/low-magnitude-mechanical-signals-and-the-spine-a-review-of-current-and-future-applications
#5
REVIEW
Martin H Pham, Zorica Buser, Jeffrey C Wang, Frank L Acosta
Animal and human studies demonstrate the anabolic properties of low-magnitude mechanical stimulation (LMMS) in its ability to improve bone formation by enhancing the proliferation of mesenchymal stem cells and their subsequent commitment down an osteoblastic lineage. Response to mechanical strains as low as 10μɛ have been seen, illustrating the sensitivity of mechanosensory cells to mechanotransduction pathways. Applications to the spine include treatment of osteoporosis in preparation for instrumented fusion, fracture reduction in spinal cord injury patients to slow bone mineral density loss, and bone tissue engineering and enhancement of bone-implant osseointegration for pseudarthrosis and hardware failure...
January 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28075460/roles-of-oncogenes-and-tumor-suppressor-genes-in-osteoclastogenesis-review
#6
Akari Minami, Mako Ogino, Noriko Nakano, Mayuko Ichimura, Atsuko Nakanishi, Toshiyuki Murai, Yasuko Kitagishi, Satoru Matsuda
Osteoporosis is a bone disease that poses a tremendous burden to health care. The receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) have been a major focus of this research field. RANKL signaling not only activates a variety of downstream signaling pathways required for osteoclast development, but crosstalk with other signaling pathways also adjusts bone homeostasis both in normal physiology and in bone disease. Consequently, novel drugs specifically targeting RANK-RANKL and their signaling pathways in osteoclasts are expected to revolutionize the treatment of various bone diseases such as osteoporosis...
February 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28072794/does-percutaneous-vertebroplasty-or-balloon-kyphoplasty-for-osteoporotic-vertebral-compression-fractures-increase-the-incidence-of-new-vertebral-fractures-a-meta-analysis
#7
Hui Zhang, Caiyuan Xu, Tongxing Zhang, Zhongyu Gao, Tao Zhang
BACKGROUND: Because of an aging population,osteoporotic vertebral fractures are becoming more frequent.Conservative therapy was considered the gold standard for treating osteoporotic vertebral compression fractures (OVCFs) in the past. Percutaneous vertebroplasty (PVP) or balloon kyphoplasty (BKP) as minimally invasive techniques are new treatments that are widely used for painful OVCFs. However, an increase in new vertebral compression fractures at non-treated levels following augmentation is of concern...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072591/osteoporosis-fracture-epidemiology-update-2016
#8
Jane A Cauley
PURPOSE OF REVIEW: The purpose of this review is to provide an update on osteoporosis epidemiology. The focus is on fractures because fractures are the most important clinical consequence of osteoporosis. Studies published over the past 18 months are identified and reviewed. Finally, the clinical impact of these new findings is discussed. RECENT FINDINGS: Important research in 2015-2016 include analyses of screening and rescreening in younger women and older men, risk factors for hip fractures in older men, obesity and weight loss/gain, and risk of fracture...
January 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28069090/effects-of-recombinant-human-growth-hormone-for-osteoporosis-systematic-review-and-meta-analysis
#9
Hayden F Atkinson, Rebecca F Moyer, Daniel Yacoub, Dexter Coughlin, Trevor B Birmingham
Our objective was to evaluate the efficacy of recombinant human growth hormone (GH) on bone mineral density (BMD) in persons age 50 and older, with normal pituitary function, with or at risk for developing osteoporosis. We systematically reviewed randomized clinical trials (RCTs), searching six databases, and conducted meta-analyses to examine GH effects on BMD of the lumbar spine and femoral neck. Data for fracture incidence, bone metabolism biomarkers, and adverse events were also extracted and analysed. Thirteen RCTs met the eligibility criteria...
January 10, 2017: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/28065646/-what-the-family-doctor-must-know-about-lung-transplantation-complications-health-promotion-and-outcomes-part-2
#10
L Zurbano, F Zurbano
The lung transplantation is a therapeutic procedure indicated for lung diseases that are terminal and irreversible (except lung cancer) despite the best medical current treatment. It is an emergent procedure in medical care. In this review, an analyse is made of the most frequent complications of lung transplant related to the graft (rejection and chronic graft dysfunction), immunosuppression (infections, arterial hypertension, renal dysfunction, and diabetes), as well as others such as gastrointestinal complications, osteoporosis...
January 5, 2017: Semergen
https://www.readbyqxmd.com/read/28064520/menopause-hormone-therapy-and-diabetes
#11
C A Stuenkel
Over the past three decades, the prevalence of diabetes has increased four-fold. Coupled with the global obesity epidemic and aging of the world's population, a perfect metabolic storm is brewing. The influence of menopause and exogenous estrogen and progestogens must be included in this equation. In this review, criteria for diagnosing diabetes and recommendations for screening are described. The reported effects of menopause on diabetes risk in healthy women are reviewed as well as the relationship between established diabetes and the timing of menopause...
January 8, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28062525/parathyroid-hormone-1-34-and-skeletal-anabolic-action-the-use-of-parathyroid-hormone-in-bone-formation
#12
L Osagie-Clouard, A Sanghani, M Coathup, T Briggs, M Bostrom, G Blunn
: Intermittently administered parathyroid hormone (PTH 1-34) has been shown to promote bone formation in both human and animal studies. The hormone and its analogues stimulate both bone formation and resorption, and as such at low doses are now in clinical use for the treatment of severe osteoporosis. By varying the duration of exposure, parathyroid hormone can modulate genes leading to increased bone formation within a so-called 'anabolic window'. The osteogenic mechanisms involved are multiple, affecting the stimulation of osteoprogenitor cells, osteoblasts, osteocytes and the stem cell niche, and ultimately leading to increased osteoblast activation, reduced osteoblast apoptosis, upregulation of Wnt/β-catenin signalling, increased stem cell mobilisation, and mediation of the RANKL/OPG pathway...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28056748/pro-inflammation-cytokines-new-potential-therapeutic-targets-for-obesity-related-bone-disorders
#13
Tian Tian Wang, Chenglin Qi He, Xi Jie Yu
Obesity was traditionally thought as a positive regulator on the strength of bone. With the in-depth study, obesity is considered as a major risk factor for osteoporosis. Some pro-inflammation cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) are the factors that fat uses to negatively regulate bone metabolism. Obese people and animals show a higher level of serum TNF-α and IL-6, which are produced by macrophages derived from adipose tissue. These pro-inflammation cytokines regulate the proliferation and apoptosis of adipocyte, promote lipolysis, inhibit lipid synthesis and decrease blood lipids through autocrine and paracrine way...
January 4, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28053920/influence-of-adolescents-physical-activity-on-bone-mineral-acquisition-a-systematic-review-article
#14
REVIEW
Mohamed S Zulfarina, Ahmad M Sharkawi, Zaris-Sm Aqilah-S N, Sabarul-Afian Mokhtar, Shuid A Nazrun, Isa Naina-Mohamed
BACKGROUND: This study conducted to examine and to provide a systematic literature over the influence of adolescents' physical activity (PA) in maximizing`s peak bone mass (PBM). PBM or the 'bone bank' is an important determinant in achieving healthy bone. PA is one of the bone's lifestyle contributors and high PBM is one of the major strategies for preventing osteoporosis. METHODS: A computerized literature search using Medline (Ovid) and Scopus were conducted to identify relevant observational studies on the influence of different level of PA on bone acquisition among the healthy adolescent population...
December 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28053645/do-metabolic-syndrome-and-its-components-have-an-impact-on-bone-mineral-density-in-adolescents
#15
REVIEW
Valéria Nóbrega da Silva, Luciana Nunes Mosca Fiorelli, Carla Cristiane da Silva, Cilmery Suemi Kurokawa, Tamara Beres Lederer Goldberg
In recent years, there has been growing concern about the occurrence of metabolic syndrome (MetS) at an early age and its effects on bone mass in adolescents. Adolescence is considered a critical period for bone mass gain. Impaired bone acquisition during this phase can lead to "suboptimal" peak bone mass and increase the risk of osteopenia/osteoporosis and fractures in old age. The objective of this review was to perform a critical analysis of articles that specifically focus on this age group, evaluating the influence of MetS and its components on bone mineral density in adolescents...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28048966/bone-density-and-clinical-periodontal-attachment-in-postmenopausal-women
#16
D C Penoni, T K S Fidalgo, S R Torres, V M Varela, D Masterson, A T T Leão, L C Maia
Osteoporosis is a systemic skeletal disease characterized by low bone mineral density (BMD) and has been considered a risk factor for periodontal disease. The aim of this systematic review and meta-analysis was to verify the scientific evidence for the association of periodontal attachment loss with low BMD in postmenopausal women. A systematic search of the literature was performed in databases until August 2016, in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines...
December 1, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/28046015/the-relationship-between-25-oh-d-levels-vitamin-d-and-bone-mineral-density-bmd-in-a-saudi-population-in-a-community-based-setting
#17
Abdullah Alkhenizan, Ahmed Mahmoud, Aneela Hussain, Alia Gabr, Suad Alsoghayer, Abdelmoneim Eldali
BACKGROUND: Vitamin D deficiency has been linked to an increased risk of osteoporosis. Vitamin D deficiency has reached high levels in the Saudi population, but there is conflicting evidence both in the Saudi population, and worldwide, regarding the existence of a correlation between these low vitamin D levels and reduced BMD (bone mineral density), or osteoporosis. OBJECTIVE: The objective of this study was primarily to determine whether there was a correlation between vitamin D deficiency and osteoporosis in the Saudi population...
2017: PloS One
https://www.readbyqxmd.com/read/28038697/correction-of-spinal-deformity-on-a-lung-transplantation-recipient
#18
José Vicente Andrés Peiró, Joan Bagó Granell, Montserrat Feliu Moret, Antonio Moreno Galdó
BACKGROUND: The coexistence of lung disease and scoliosis entails a dramatic situation. There are no papers reporting scoliosis surgery in patients who suffered lung transplantation. PURPOSE: To describe the case of a patient who underwent surgery to correct progressive spinal deformity after two consecutive lung transplants. STUDY DESIGN: Case report, including review of patient records, imaging and pulmonary function tests, and literature review...
January 2017: Spine Deformity
https://www.readbyqxmd.com/read/28035992/osteogenic-differentiation-in-healthy-and-pathological-conditions
#19
REVIEW
Maria Teresa Valenti, Luca Dalle Carbonare, Monica Mottes
This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC), bone formation and turn-over in good and ill skeletal fates. The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described. Then, alterations of the molecular pathways regulating osteogenesis are addressed. In the aging process, as well as in glucocorticoid-induced osteoporosis, bone loss is caused not only by an unbalanced bone resorption activity, but also by an impairment of MSCs' commitment towards the osteogenic lineage, in favour of adipogenesis...
December 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28034659/toxins-and-pharmacologically-active-compounds-from-species-of-the-family-bufonidae-amphibia-anura
#20
REVIEW
Candelario Rodríguez, Louise Rollins-Smith, Roberto Ibáñez, Armando A Durant-Archibold, Marcelino Gutiérrez
ETHNOPHARMACOLOGICAL RELEVANCE: Among amphibians, 15 of the 47 species reported to be used in traditional medicines belong to the family Bufonidae, which demonstrates their potential in pharmacological and natural products research. For example, Asian and American tribes use the skin and the parotoid gland secretions of some common toads in the treatment of hemorrhages, bites and stings from venomous animals, skin and stomach disorders, as well as several types of cancers. OVERARCHING OBJECTIVE: In addition to reviewing the occurrence of chemical constituents present in the family Bufonidae, the cytotoxic and biomedical potential of the active compounds produced by different taxa are presented...
December 26, 2016: Journal of Ethnopharmacology
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