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https://www.readbyqxmd.com/read/27913280/neuropsychological-functioning-and-chronic-methadone-use-a-systematic-review-and-meta-analysis
#1
REVIEW
A Baldacchino, M Armanyous, D J K Balfour, G Humphris, K Matthews
INTRODUCTION: There is a presumption that neurocognition is commonly impaired in chronic methadone exposed individuals (CM) when compared with healthy controls (HP). Additionally, it remains unclear if short term (<1year) abstinence (AP) is associated with an altered cognitive profile when compared with CM. METHOD: A random effect model approach was used on data assembled into the Comprehensive Meta-Analysis programme. Cohen's d effect sizes and a significance levels of p<0...
November 29, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27903358/-comparison-of-genotypes-of-hepatitis-c-virus-between-chinese-and-burmese-drug-users-living-in-dehong-prefecture-yunnan-province
#2
Y K Wang, K D Feng, J B Wang, Z M Zhang, R H Tang, R H Ye, J N Zhang, Y C Yang, M F Qiu, S Duan
Objective: To analyze the distribution of hepatitis C virus (HCV) genotypes among Chinese and Burmese drug users in Dehong Prefecture, Yunnan Province. Methods: Plasma specimens and relevant epidemiological data were collected from 7 545 drug users attending rehabilitation centers and methadone clinics in Dehong Prefecture from January to September in 2015, of which 752 were positive for HCV antibodies. HCV RNA was then extracted from 139 random specimens (64 Burmese and 75 Chinese) and the CE1 and NS5B regions were amplified by nested PCR...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27898496/distinctive-trajectories-of-opioid-use-over-an-extended-follow-up-of-patients-in-a-multisite-trial-on-buprenorphine%C3%A2-%C3%A2-naloxone-and-methadone
#3
Yih-Ing Hser, David Huang, Andrew J Saxon, George Woody, Andrew L Moskowitz, Abigail G Matthews, Walter Ling
OBJECTIVES: Uncovering heterogeneities in longitudinal patterns (trajectories) of opioid use among individuals with opioid use disorder can increase our understanding of disease progression and treatment responses to improve care. The present study aims to identify distinctive opioid use trajectories and factors associated with these patterns among participants randomized to treatment with methadone (MET) or buprenorphine + naloxone (BUP). METHODS: Growth mixture modeling was applied to identify distinctive opioid use trajectories among 795 opioid users after their enrollment in a multisite trial during 2006 to 2009, with follow-up interviews conducted during 2011 to 2014...
November 24, 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27889436/wide-variation-found-in-care-of-opioid-exposed-newborns
#4
Debra L Bogen, Bonny L Whalen, Laura R Kair, Mark Vining, Beth A King
OBJECTIVE: Standardized practices for the management of neonatal abstinence syndrome (NAS) are associated with shorter lengths of stay, but optimal protocols are not established. We sought to identify practice variations for newborns with in utero chronic opioid exposure among hospitals in the Better Outcomes Through Research for Newborns (BORN) network. METHODS: Nursery site leaders completed a survey about hospitals' policies and practices regarding care for infants with chronic opioid exposure (≥3 weeks)...
November 23, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/27872705/sophora-alopecuroides-l-var-alopecuroides-alleviates-morphine-withdrawal-syndrome-in-mice-involvement-of-alkaloid-fraction-and-matrine
#5
Saeed Kianbakht, Fataneh Hashem Dabaghian
OBJECTIVES: Evaluation of the Sophora alopecuroides var. alopecuroides seed effects on morphine withdrawal syndrome in mice and determination of the alkaloid composition of the seed total extract. MATERIALS AND METHODS: The effects of the seed total extract, alkaloid fraction and major compound matrine on the mice morphine withdrawal syndrome were compared to saline and methadone. Mice were made dependent on morphine by morphine sulfate injection 3 times a day for 3 days...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27870477/ascending-single-dose-double-blind-placebo-controlled-safety-study-of-noribogaine-in-opioid-dependent-patients
#6
Paul Glue, Gavin Cape, Donna Tunnicliff, Michelle Lockhart, Fred Lam, Noelyn Hung, C Tak Hung, Sarah Harland, Jane Devane, R S Crockett, John Howes, Borje Darpo, Meijian Zhou, Holger Weis, Lawrence Friedhoff
Ibogaine is a psychoactive substance that may reduce opioid withdrawal symptoms. This was the first clinical trial of noribogaine, ibogaine's active metabolite, in patients established on methadone opioid substitution therapy (OST). In this randomized, double-blind, placebo-controlled single ascending-dose study, we evaluated the safety, tolerability, and pharmacokinetics of noribogaine in 27 patients seeking to discontinue methadone OST who had been switched to morphine during the previous week. Noribogaine doses were 60, 120, or 180 mg (n = 6/dose level) or matching placebo (n = 3/dose level)...
November 2016: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/27859761/methadone-complications-amongst-opioid-dependent-patients-in-malaysia-a-case-series
#7
Philip George, Balasingam Vicknasingam, Sivakumar Thurairajasingam, Parameswaran Ramasamy, Haslina Mohd Yusof, Mohd Azhar Bin Mohd Yasin, Zia U Bahkt Sultan Shah
INTRODUCTION AND AIMS: Opioid dependence remains the main type of illicit substance used in Malaysia, which has an estimated 187 771 opiate users. There are currently 333 active methadone maintenance treatment centres nationwide. Although methadone has proven to be an effective maintenance therapy, it has clinical concerns which can have an impact on its effectiveness and safety. DESIGN, METHODS AND RESULTS: A case series of seven patients from Malaysian private and public hospital settings who had an adverse reaction with methadone is discussed...
November 8, 2016: Drug and Alcohol Review
https://www.readbyqxmd.com/read/27855842/methadone-maintenance-treatment-may-be-associated-with-bruxism-in-male-prisoners
#8
Daniele Manfredini
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Methadone treatment, bruxism, and temporomandibular disorders among male prisoners. Enguelberg-Gabbay JV, Schapir L, Israeli Y, Hermesh H, Weizman A, Winocur E. Eur J Oral Sci 2016;124(3): 266-71. SOURCE OF FUNDING: None TYPE OF STUDY/DESIGN: Cross-sectional study.
September 2016: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/27844471/clinically-relevant-concentrations-of-opioids-for-in-vitro-studies
#9
Jason W Boland, A Graham Pockley
OBJECTIVES: Numerous in vitro studies have evaluated the influence of opioids on many biological and immunological processes. The concentrations that have been used in these studies span a large range and often do not reflect levels that are present in the relevant patient groups. This article reviews the literature concerning the concentrations of opioids that are detected in patients so that the concentrations of opioids that are used for in vitro studies can better reflect those that are present clinically...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27810209/transcranial-magnetic-stimulation-with-acepromazine-or-dexmedetomidine-in-combination-with-levomethadone-fenpipramide-in-healthy-beagle-dogs
#10
H-L Amendt, J S Siedenburg, N Steffensen, F J Söbbeler, A Schütter, J Tünsmeyer, K Rohn, S B R Kästner, A Tipold, V M Stein
The aim of this study was to evaluate the influence of two sedation protocols on transcranial magnetic motor evoked potentials (TMMEPs) after transcranial magnetic stimulation in medium sized dogs. Onset latencies and peak-to-peak amplitudes, elicited in the extensor carpi radialis and cranial tibial muscles, were analysed in 10 healthy Beagles that received either acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide, in a crossover design. Similar TMMEP recordings could be made using both sedation protocols at 80-90% stimulation intensity; however, there were significantly shorter onset latencies with the acepromazine-levomethadone/fenpipramide protocol at 100% stimulation intensity...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27802492/national-trends-in-hospitalizations-for-opioid-poisonings-among-children-and-adolescents-1997-to-2012
#11
Julie R Gaither, John M Leventhal, Sheryl A Ryan, Deepa R Camenga
Importance: National data show a parallel relationship between recent trends in opioid prescribing practices and hospitalizations for opioid poisonings in adults. No similar estimates exist describing hospitalizations for opioid poisonings in children and adolescents. Objective: To describe the incidence and characteristics of hospitalizations attributed to opioid poisonings in children and adolescents. Design, Setting, and Participants: Retrospective analysis of serial cross-sectional data from a nationally representative sample of US pediatric hospital discharge records collected every 3 years from January 1, 1997, through December 31, 2012...
October 31, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27798073/drugged-drivers-blood-concentrations-in-england-and-wales-prior-to-the-introduction-of-per-se-limits
#12
Brian Rooney, Goncalo Jorge Gouveia, Neville Isles, Lynda Lawrence, Tara Brodie, Zorana Grahovac, Mark Chamberlain, Gavin Trotter
This report details the blood concentration of drugs found in motorists suspected of driving under the influence of drugs from 2010 to 2012 in England and Wales. This study was carried out as new legislation has come into place, setting fixed blood concentration limits for drugs in motorists. These include a cannabis (Δ9-THC) blood concentration of 2 µg/L, amphetamine 250 µg/L, benzoylecgonine (BZE) 50 µg/L, cocaine 10 µg/L, 6-monoacetylmorphine 5 µg/L, morphine 80 µg/L, diazepam 550 µg/L and methadone 500 µg/L...
October 26, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27784231/effect-of-oral-methadone-on-ecg-characteristics-and-endocrine-hormonal-changes-and-their-inter-relationship
#13
Shokoufeh Bonakdaran, Mahdi Hassan Zadeh Daloee, Ali Akhoondpoor Manteghi, Mina Akbarirad, Abdollah Firoozi, Fatemeh Akbarirad
INTRODUCTION: Methadone is the most common opioid in use for opioid substitution therapy. The Relation of methadone and electrocardiographic findings is nearly well known while the relationship between its electrocardiographic indexes and hormonal changes are not well recognized. OBJECTIVE: To evaluate the hormonal changes in patients who are taking methadone maintenance treatment (MMT) and its effects on electrocardiographic indexes, in comparison with healthy control groups...
October 26, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27780901/fentanyl-and-methadone-used-as-adjuncts-to-bupivacaine-for-lumbosacral-epidural-analgesia-in-sheep
#14
R DeRossi, R C Pagliosa, A Q de Carvalho, G G Macedo, L C Hermeto
Six healthy, female, mixed-breed 18-24-month-old sheep weighing 30-48 kg were submitted to lumbosacral epidural bupivacaine in combination with either methadone or fentanyl. Epidural catheters were placed in six sheep that were given three treatments: (Bup) bupivacaine (0.5 mg/kg) alone; (BupMet) bupivacaine (0.25 mg/kg) plus methadone (0.3 mg/kg); and (BupFent) bupivacaine (0.25 mg/kg) plus fentanyl (0.002 mg/kg). Haemodynamic variables, respiratory rate, rectal temperature, analgesia by applying a standard painful stimulus, motor block and sedative scores were compared among the three treatments...
October 25, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27776677/from-long-term-injecting-to-long-term-non-injecting-heroin-and-cocaine-use-the-persistence-of-changed-drug-habits
#15
Don C Des Jarlais, Kamyar Arasteh, Jonathan Feelemyer, Courtney McKnight, David M Barnes, Susan Tross, David C Perlman, Aimee N C Campbell, Hannah L F Cooper, Holly Hagan
OBJECTIVES: Transitioning from injecting to non-injecting routes of drug administration can provide important individual and community health benefits. We assessed characteristics of persons who had ceased injecting while continuing to use heroin and/or cocaine in New York City. METHODS: We recruited subjects entering Mount Sinai Beth Israel detoxification and methadone maintenance programs between 2011 and 2015. Demographic information, drug use histories, sexual behaviors, and "reverse transitions" from injecting to non-injecting drug use were assessed in structured face-to-face interviews...
December 2016: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/27770163/biliary-and-pancreatic-ductal-dilation-in-patients-on-methadone-maintenance-therapy
#16
David D B Bates, Dorathy Tamayo-Murillo, Steven Kussman, Adam Luce, Christina A LeBedis, Jorge A Soto, Stephan W Anderson
PURPOSE: To determine whether the diameter of intrahepatic and extrahepatic bile ducts and pancreatic ducts in patients on methadone maintenance therapy is increased when compared with control subjects. METHODS: Between January 1, 2000 and March 15, 2013, a total of 97 patients (mean age 49.9, range 22-79, 65 male, 32 female) were identified who were receiving chronic methadone maintenance therapy (MMT) when they underwent imaging with abdominal MRI or a contrast-enhanced abdominopelvic CT...
October 21, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27755017/aripiprazole-for-cocaine-abstinence-a-randomized-controlled-trial-with-ecological-momentary-assessment
#17
Landhing M Moran, Karran A Phillips, William J Kowalczyk, Udi E Ghitza, Daniel A Agage, David H Epstein, Kenzie L Preston
Aripiprazole blocks psychostimulant seeking in a rat model of relapse. However, in humans, it may increase ongoing use. We tested aripiprazole specifically for relapse prevention. Methadone-maintained outpatients who were abstinent from cocaine in weeks 11-12 were randomized to double-blind aripiprazole (15 mg daily) or placebo in weeks 13-27 after 12 weeks of contingency management. Participants reported craving through ecological momentary. We stopped the trial because very few (18/41) participants fulfilled the abstinence criterion...
October 14, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27752867/first-report-of-gender-based-violence-as-a-deterrent-to-methadone-access-among-females-who-use-heroin-in-dar-es-salaam-tanzania
#18
Divya Balaji, Linda B Mlunde, Olivia C Tran, Barrot Lambdin, Jessie Mbwambo, Cassian Nyandindi, Eva Matiko, Michael Copenhaver, R Douglas Bruce
High prevalence of human immunodeficiency virus (HIV) among females who use drugs in Dar es Salaam, Tanzania, contrasts strikingly with their low enrollment in HIV risk reduction services such as methadone assisted therapy (MAT). We conducted a case-control study to examine factors associated with non-enrollment in MAT, with a focus on gender-based violence. We interviewed 202 female heroin users not enrolled in MAT as cases and 93 females enrolled in MAT. We fitted logistic regression models with MAT enrollment as the outcome of interest...
October 17, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27746341/growth-hormone-is-protective-against-acute-methadone-induced-toxicity-by-modulating-the-nmda-receptor-complex
#19
Erik Nylander, Alfhild Grönbladh, Sofia Zelleroth, Shanti Diwakarla, Fred Nyberg, Mathias Hallberg
Human growth hormone (GH) displays promising protective effects in the central nervous system after damage caused by various insults. Current evidence suggests that these effects may involve N-methyl-d-aspartate (NMDA) receptor function, a receptor that also is believed to play a role in opioid-induced neurotoxicity. The aims of the present study were to examine the acute toxic effects of methadone, an opioid receptor agonist and NMDA receptor antagonist, as well as to evaluate the protective properties of recombinant human GH (rhGH) on methadone-induced toxicity...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27740713/tincture-of-opium-for-treating-opioid-dependence-a-systematic-review-of-safety-and-efficacy
#20
Mohammadali Nikoo, Nooshin Nikoo, Sanam Javid, Afshar Amiri, Marc Vogel, Fiona Choi, Amir Ali Sepehry, Amir Hooshang Bagheri Valoojerdi, Kerry Jang, Christian Schütz, Shahin Akhondzadeh, Michael Krausz
BACKGROUND AND AIMS: Recently, there has been a growing interest in using Opium Tincture (OT) for treating opioid dependence in certain regions. We aimed to assess the evidence on its safety and efficacy for this indication. METHODS: We searched several databases (CENTRAL, Medline, EMBASE, Web of Science, PsychINFO, ProQuest Dissertation & Theses Database, Iran Medex, clinicaltrials.gov, and who.int/trialsearch) with no language or publication date limitations. Two reviewers selected Randomized Controlled Trials (RCT), cohort /case-control/ cross-sectional studies and case-series on safety or efficacy of OT for treating opioid dependence and then extracted reported measures of mentioned outcomes from selected studies...
October 14, 2016: Addiction
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