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https://www.readbyqxmd.com/read/29665978/outpatient-intravenous-multimodal-elastomeric-pump-with-methadone-in-ambulatory-surgery
#1
L Gómez-López, X Sala-Blanch, P L Gambús Cerrillo, A López Gutiérrez, M Agustí Lasús, M T Anglada Casas
BACKGROUND AND OBJECTIVE: Analgesia in Ambulatory Surgery (AS) needs to evolve in parallel with surgical complexity. We designed a study to try to improve analgesia in painful surgery using an intravenous elastomeric pump. As a novelty, methadone was included. PATIENTS AND METHODS: An observational study, physical status ASA I-II, underwent ambulatory surgeries with moderate-severe postoperative pain. Analgesia was administered for 48h by an intravenous multimodal elastomeric pump (methadone, tramadol, dexketoprofen and ondansetron at low doses)...
April 14, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29664690/methadone-as-the-initial-long-acting-opioid-in-children-with-advanced-cancer
#2
Kevin Madden, Sarah Mills, Seyedeh Dibaj, Janet L Williams, Diane Liu, Eduardo Bruera
BACKGROUND: Methadone is an attractive medication for treating children with advanced cancer with pain as it is the only long-acting opioid available as a liquid. However, it is not frequently used due to concerns about potential toxicities and side effects. OBJECTIVE: Evaluate the efficacy and safety of methadone as the first long-acting opioid in children with advanced cancer. DESIGN: Retrospective chart review of 52 consecutive patients referred to Pediatric Supportive Care for pain management started on methadone as their first long-acting opioid...
April 17, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29607939/a-novel-method-for-determination-of-methadone-in-the-serum-by-high-performance-liquid-chromatography-with-electrochemical-detection
#3
Hideya Kokubun, Chizuko Takigawa, Kanako Miyano, Yasuhito Uezono
In March 2013, the clinical use of oral methadone tablets was initiated in Japan. There are many factors responsible for the change in blood concentrations of methadone, and its pharmacokinetics is very complex. Therefore, a simple and accurate measurement method for methadone blood concentrations was developed using HPLC/electrochemical detector (ECD). An eluent of 10 mM Na2 HPO4 /CH3 CN/CH3 OH (20 : 19 : 3) was used as the mobile phase. The column was used the XTerra® RP18, and the voltage of the ECD was set at 400 to 800 mV...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29606226/a-pilot-study-of-a-smartphone-application-supporting-recovery-from-drug-addiction
#4
Di Liang, Hui Han, Jiang Du, Min Zhao, Yih-Ing Hser
BACKGROUND: Mobile health (mHealth) technologies have the potential to facilitate self-monitoring and self-management for individuals with substance use disorders (SUD). S-Health is a bilingual smartphone application based on cognitive behavioral principles and is designed to support recovery from drug addiction by trigger recognition so as to allow practice in-the-moment coping to prevent relapse. METHOD: For this pilot randomized controlled study, 75 participants were recruited from methadone maintenance treatment clinics and the social worker consortium in Shanghai, China...
May 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29602151/usefulness-of-hair-analysis-and-psychological-tests-for-identification-of-alcohol-and-drugs-of-abuse-consumption-in-driving-license-regranting
#5
Elena Lendoiro, Ana de Castro, Cristian Jiménez-Morigosa, Xosé A Gomez-Fraguela, Manuel López-Rivadulla, Angelines Cruz
The implementation of the points-based driving license helps to change the drivers' behavior and is related to a reduction of traffic accidents and fatalities. In Spain, when a driver loses all points, the driving license is revoked, so the driver must enroll on a Driver Awareness and Re-education (DARE) course. However, at the moment offenders are not submitted to any test to confirm absence of alcohol or drugs of abuse consumption, even when 9% of Spanish drivers lose their driving license for driving under the influence (DUI)...
March 20, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29601303/the-opioid-epidemic-and-pregnancy-implications-for-anesthetic-care
#6
Britany L Raymond, Bradley T Kook, Michael G Richardson
PURPOSE OF REVIEW: This review summarizes evolving knowledge regarding adverse maternal, fetal, and neonatal effects of opioid exposure during pregnancy, and current treatment options for opioid use disorder (OUD). Maternal and fetal implications of maternal opioid maintenance with methadone and buprenorphine are described. Finally, acute and chronic pain management strategies in opioid-tolerant parturients are reviewed. RECENT FINDINGS: Opioid use among parturients has risen dramatically, with opioid use during pregnancy as high as 20%...
March 29, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29582199/integrated-bio-behavioral-approach-to-improve-adherence-to-pre-exposure-prophylaxis-and-reduce-hiv-risk-in-people-who-use-drugs-a-pilot-feasibility-study
#7
Roman Shrestha, Frederick L Altice, Pramila Karki, Michael M Copenhaver
This study reports the feasibility, acceptability, and preliminary efficacy of the bio-behavioral community-friendly health recovery program-an integrated, HIV prevention intervention to improve pre-exposure prophylaxis (PrEP) adherence and HIV-risk reduction behaviors among high-risk people who use drugs. We used a within-subjects, pretest-posttest follow-up design to recruit participants, who were HIV-uninfected, methadone-maintained and reported HIV-risk behaviors and had initiated PrEP (n = 40; males: 55%)...
March 26, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29580450/opioid-utilization-by-pregnant-women-with-sickle-cell-disease-and-the-risk-of-neonatal-abstinence-syndrome
#8
Aisha Nnoli, Neil S Seligman, Kevin Dysart, Jason K Baxter, Samir K Ballas
BACKGROUND: Pregnant women with sickle cell disease (SCD) are at increased risk of maternal and fetal complications. There are limited data on the outcome of the treatment of VOCs with opioids in relation to neonatal complications during pregnancy. METHODS: This is a retrospective cohort study of women with SCD from January 1999 to December 2008. Women with SCD were identified by ICD-9 codes and matched 2:1 to a control group of women on methadone for opioid dependence...
April 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29579725/addressing-discordant-quantitative-urine-buprenorphine-and-norbuprenorphine-levels-case-examples-in-opioid-use-disorder
#9
Stephen R Holt, Joseph H Donroe, Dana A Cavallo, Jeanette M Tetrault
INTRODUCTION: Urine adulteration is a concern among patients treated for opioid use disorder. Quantitative urine testing for buprenorphine (B) and norbuprenorphine (NB), and the appropriate interpretation of B and NB levels, can facilitate constructive conversations with patients that may lead to modifications in the treatment plan, and strengthening of the patient-provider relationship. CASE SUMMARY: Three cases are presented in which discordant urine B and NB levels were recognized...
March 2, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29574368/estimation-of-the-consumption-of-illicit-drugs-during-special-events-in-two-communities-in-western-kentucky-usa-using-sewage-epidemiology
#10
Katelyn S Foppe, Dena R Hammond-Weinberger, Bikram Subedi
Sewage epidemiology is a cost-effective, comprehensive, and non-invasive technique capable of determining semi-real-time community usage of drugs utilizing the concentration of drug residues in wastewater, wastewater inflow, and the population size served by a wastewater treatment plant. In this study, semi-real-time consumption rates of ten illicit drugs were determined using sewage epidemiology during special events including Independence Day, the 2017 solar eclipse, and the first week of an academic semester in the Midwestern United States...
March 22, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29567839/concurrent-drug-use-among-methadone-maintenance-patients-in-mountainous-areas-in-northern-vietnam
#11
Bach Xuan Tran, Victoria L Boggiano, Huong Lan Thi Nguyen, Long Hoang Nguyen, Hung Van Nguyen, Canh Dinh Hoang, Huong Thi Le, Tho Dinh Tran, Hai Quan Le, Carl A Latkin, Thuc Minh Thi Vu, Melvyn Wb Zhang, Roger Cm Ho
OBJECTIVES: With the rise in methadone maintenance therapy (MMT) for drug users in Vietnam, there has been growing interest in understanding if and how often MMT patients engage in concurrent illicit drug use while on methadone therapy in various settings. This study examined factors associated with concurrent opioid use among patients on MMT in a mountainous area in Vietnam. SETTING: One urban and one rural MMT clinics in Tuyen Quang province. PARTICIPANTS: Survey participants consisted of patients who were taking MMT at the selected study sites...
March 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29556689/-compartment-syndrome-of-the-forearm-after-intra-arterial-self-injection-with-a-mixture-of-methadone-flunitrazepam-saliva-and-water
#12
S J M Kamphuis, A R Jandali, F J Jung, J Sproedt
A drug-addicted patient injected himself intra-arterially with a mixture of methadone, flunitrazepam, saliva and water. The resulting compartment syndrome could be treated by fasciotomy and multiple debridement, with which a major amputation could be prevented. The course of the treatment and the resulting functional results are described, as well as a brief overview of the literature and a treatment proposal for similar cases.
March 19, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29551551/correlates-of-specialty-substance-use-treatment-among-adults-with-opioid-use-disorders
#13
Eric Romo, Christine M Ulbricht, Robin E Clark, Kate L Lapane
AIMS: To identify factors associated with the receipt of specialty substance use treatment among adults with opioid use disorders (OUD). DESIGN: Cross-sectional study based on 2010-2014 National Surveys on Drug Use and Health (NSDUH). SETTING AND PARTICIPANTS: Adults with a past-year OUD (n = 2488). The sample is representative of non-institutionalized US adults. MEASUREMENTS: Past-year OUD was determined using DSM-IV criteria...
March 11, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29544903/low-dose-intramuscular-methadone-for-acute-mild-to-moderate-opioid-withdrawal-syndrome
#14
Mark K Su, Jessica Hetherington Lopez, Aldo Crossa, Robert S Hoffman
STUDY OBJECTIVE: To assess the efficacy of 10mg intramuscular (IM) methadone in patients with opioid withdrawal syndrome (OWS). METHODS: This was a prospective observational, convenience sample of patients presenting to the ED with mild to moderate OWS. Evaluations included the Clinical Opiate Withdrawal Scale (COWS), Withdrawal Symptoms Scale (WSS), Altered Mental Status Scale (AMSS) and a physician assessment of the patient's WSS (MDWSS). After enrollment, 10mg of IM methadone was administered and patients were reassessed at 30min post-methadone administration...
March 2, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29544189/methadone-treatment-severe-food-insecurity-and-hiv-hcv-co-infection-a-propensity-score-matching-analysis
#15
Taylor McLinden, Erica E M Moodie, Anne-Marie Hamelin, Sam Harper, Carmine Rossi, Sharon L Walmsley, Sean B Rourke, Curtis Cooper, Marina B Klein, Joseph Cox
BACKGROUND: Severe food insecurity (FI) is common among individuals living with HIV-hepatitis C virus (HCV) co-infection. We hypothesize that the injection of opioids is partly responsible for the association between injection drug use and severe FI. Therefore, this analysis examines whether methadone maintenance treatment for opioid dependence is associated with a lower risk of severe FI. METHODS: We used biannual data from the Canadian Co-infection Cohort (N = 608, 2012-2015)...
February 20, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29529456/rehospitalization-and-substance-use-disorder-sud-treatment-entry-among-patients-seen-by-a-hospital-sud-consultation-liaison-service
#16
Courtney D Nordeck, Christopher Welsh, Robert P Schwartz, Shannon Gwin Mitchell, Art Cohen, Kevin E O'Grady, Jan Gryczynski
BACKGROUND: Substance use disorders (SUD) are associated with non-adherence to medical care and high utilization of hospital services. This study characterized patterns and correlates of rehospitalization among patients seen by a hospital-based SUD consultation-liaison (CL) team. METHODS: This study was a retrospective medical record review of patients in a large urban academic hospital who received SUD consultation and were diagnosed with opioid, cocaine, and/or alcohol use disorder (N = 267)...
March 2, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29527296/management-of-eight-labor-and-delivery-patients-dependent-on-buprenorphine-subutex%C3%A2-a-retrospective-chart-review
#17
Solina Tith, Garinder Bining, Laurent Bollag
Background : Opioid use during pregnancy is a growing concern in the United States. Buprenorphine has been recommended by "The American College of Obstetrics and Gynecology" as an alternative to methadone to decrease risks associated with the use of illicit opioids during pregnancy. The partial μ-opioid agonists' unique pharmacology, including its long half time and high affinity to the μ-opioid receptor, complicates patient management in a highly kinetic, and often urgent field like obstetric anesthesia...
2018: F1000Research
https://www.readbyqxmd.com/read/29524872/illegal-drug-use-and-its-correlates-in-san-juan-puerto-rico
#18
Raul Caetano, Patrice A C Vaeth, Glorisa Canino
BACKGROUND: Data on the prevalence and correlates of illegal drug use in Puerto Rico are now almost 20 years old. OBJECTIVES: This study sought to estimate the 12-month prevalence of illegal and non-prescribed medical drug use in San Juan, Puerto Rico and identify sociodemographic correlates of use. METHODS: Data are from a random household sample of 1510 individuals, 18-64 years of age in San Juan, Puerto Rico. RESULTS: The 12-month prevalence of any illegal or non-prescribed drug use was 16...
February 21, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29516505/methadone-against-cancer-lost-in-translation
#19
REVIEW
Dirk Theile, Gerd Mikus
Recently, the opioid analgesic D,L-methadone has gained much attention as a potential antineoplastic compound, considerably triggered through lay press and media. In consequence, physicians and pharmacists are currently confronted with numerous patients willing to use D,L-methadone against their malignancies. Well-performed in vitro and in vivo models have in fact shown pro-apoptotic effects of D,L-methadone or other opioids, but also proliferation-stimulating properties. Moreover, the mechanisms of proposed opioid-stimulated apoptosis are incompletely described or contradicting...
March 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29514583/a-prospective-observational-study-of-emergency-department-presentations-following-novel-psychoactive-substance-use
#20
David E Henshall, Callum Wd Innes, Scott R Morrison, Blair Wilson, Ryan A Brown, Shannon M McAllister, Seamus L Culshaw, Elaina Reda
Background and aims Novel psychoactive substances are compounds intended to mimic the effects of illicit drugs. They provide a unique challenge to healthcare, as complications of their use and their impact on services are relatively unknown. This study aims to determine nature of presentations, patient demographics and impact on healthcare. Methods Novel psychoactive substances users who presented to a large urban emergency department over 4 weeks were prospectively identified and followed for 1 year. Patients over 13 years old were eligible for inclusion...
January 1, 2018: Scottish Medical Journal
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