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https://www.readbyqxmd.com/read/29444687/psychometric-properties-of-the-medical-outcomes-study-social-support-survey-among-methadone-maintenance-patients-in-ho-chi-minh-city-vietnam-a-validation-study
#1
Long Quynh Khuong, Tuong-Vi Thi Vu, Van-Anh Ngoc Huynh, Truc Thanh Thai
BACKGROUND: Social support plays a crucial role in the treatment and recovery process of patients engaging in methadone maintenance treatment (MMT). However, there is a paucity of research about social support among MMT patients, possibly due to a lack of appropriate measuring tools. This study aimed to evaluate the psychometric properties of the Vietnamese version of the Medical Outcomes Study: Social Support Survey (MOS-SSS) among MMT patients. METHODS: A cross-sectional survey of 300 patients was conducted in a methadone clinic in Ho Chi Minh City, Vietnam...
February 14, 2018: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29441714/time-dependent-regional-brain-distribution-of-methadone-and-naltrexone-in-the-treatment-of-opioid-addiction
#2
Belin G Teklezgi, Annapurna Pamreddy, Sooraj Baijnath, Hendrik G Kruger, Tricia Naicker, Nirmala D Gopal, Thavendran Govender
Opioid addiction is a serious public health concern with severe health and social implications; therefore, extensive therapeutic efforts are required to keep users drug free. The two main pharmacological interventions, in the treatment of addiction, involve management with methadone an mu (μ)-opioid agonist and treatment with naltrexone, μ-opioid, kappa (κ)-opioid and delta (δ)-opioid antagonist. MET and NAL are believed to help individuals to derive maximum benefit from treatment and undergo a full recovery...
February 14, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29432974/similarities-and-changes-between-15-and-24-year-survival-and-retention-rates-of-patients-in-a-large-medical-affiliated-methadone-maintenance-treatment-mmt-center
#3
Einat Peles, Shaul Schreiber, Anat Sason, Miriam Adelson
BACKGROUND: Environmental and social trends and patients' characteristics may affect predictors for methadone maintenance treatment (MMT) outcome. METHODS: We have expanded our previous study of predictors for MMT outcome (from 619 to 890 patients) and the study period (from 15 to 24 years). Survival and retention in MMT since admission to the MMT clinic (6/1993-6/2016) and until death or study closure (6/2017) were compiled and analyzed. RESULTS: Of 890 patients ever admitted (10,146...
February 7, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29429442/heroin-detoxification-during-pregnancy-a-systematic-review-and-retrospective-study-of-the-management-of-heroin-addiction-in-pregnancy
#4
K V Gilfillan, L Dannatt, D J Stein, B Vythilingum
BACKGROUND: There is general consensus that methadone maintenance is the gold standard in the management of pregnant heroin users. However, in South African state hospitals, methadone withdrawal is the routine procedure offered to these patients, as methadone maintenance programmes are unavailable in the public sector. OBJECTIVES: To conduct a systematic review of the literature on heroin detoxification in pregnancy, and to document pregnancy outcomes in heroin users detoxified with methadone at Groote Schuur Hospital (GSH), Cape Town, from 2006 to 2010...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29426304/rationale-design-and-methodology-of-a-trial-evaluating-three-models-of-care-for-hcv-treatment-among-injection-drug-users-on-opioid-agonist-therapy
#5
Matthew J Akiyama, Linda Agyemang, Julia H Arnsten, Moonseong Heo, Brianna L Norton, Bruce R Schackman, Benjamin P Linas, Alain H Litwin
BACKGROUND: People who inject drugs (PWID) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). Treatment of PWID is complex due to addiction, mental illness, poverty, homelessness, lack of positive social support, poor adherence-related skills, low motivation and knowledge, and poor access to and trust in the health care system. New direct-acting antiviral medications are available for HCV with high cure rates and few side effects. The life expectancy and economic benefits of new HCV treatments will not be realized unless we determine optimal models of care for the majority of HCV-infected patients...
February 9, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29415856/a-qualitative-assessment-of-attitudes-about-and-preferences-for-extended-release-naltrexone-a-new-pharmacotherapy-to-treat-opioid-use-disorders-in-ukraine
#6
Ruthanne Marcus, Martha J Bojko, Alyona Mazhnaya, Iuliia Makarenko, Sergii Filippovych, Sergii Dvoriak, Frederick L Altice, Sandra A Springer
Numerous individual barriers, including negative attitudes toward opioid agonist therapies (OAT), have undermined HIV prevention efforts in Ukraine where the epidemic is concentrated in people who inject drugs (PWID). The recent availability of extended-release naltrexone (XR-NTX), an opioid antagonist, provides new opportunities for treatment and prevention, but little is known about patient preferences. We conducted qualitative analysis using focus groups (FG) of PWID recruited based on OAT experience: currently, previously, and never on OAT in five Ukrainian cities...
March 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29415848/opioid-recovery-initiation-pilot-test-of-a-peer-outreach-and-modified-recovery-management-checkup-intervention-for-out-of-treatment-opioid-users
#7
Christy K Scott, Christine E Grella, Lisa Nicholson, Michael L Dennis
The recent surge in opioid-related overdoses and related fatalities underscores the need for assertive mechanisms for linking individuals with opioid use disorders (OUD) to medication-assisted treatment (MAT). This pilot study investigated the feasibility of an intervention that used peer outreach workers to identify out-of-treatment individuals with OUD combined with a modified version of the Recovery Management Checkup to link individuals to methadone treatment. The study was conducted in high-risk communities in Chicago over 8weeks; peer outreach workers identified 88 active opioid/heroin users; 72 were screened as eligible, and 70 showed to the study intake/initial linkage meeting...
March 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29415846/associations-between-pharmacotherapy-for-opioid-dependence-and-clinical-and-criminal-justice-outcomes-among-adults-with-co-occurring-serious-mental-illness
#8
Allison G Robertson, Michele M Easter, Hsiu-Ju Lin, Linda K Frisman, Jeffrey W Swanson, Marvin S Swartz
Adults suffering from a serious mental illness (SMI) and a substance use disorder are at especially high risk for poor clinical outcomes and also arrest and incarceration. Pharmacotherapies for treating opioid dependence could be a particularly important mode of treatment for opioid-dependent adults with SMI to lower their risk for overdose, high-cost hospitalizations, repeated emergency department visits, and incarceration, given relapse rates are very high following detoxification in the absence of one of the three FDA-approved pharmacotherapies...
March 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29413569/evaluation-of-a-combination-of-alfaxalone-and-methadone-with-or-without-midazolam-for-premedication-in-healthy-dogs
#9
F Micieli, L R Duffee, L Chiavaccini, G Vesce, G Gianotti
No abstract text is available yet for this article.
September 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29413437/prenatal-exposure-to-methadone-or-buprenorphine-early-childhood-developmental-outcomes
#10
Karol Kaltenbach, Kevin E O'Grady, Sarah H Heil, Amy L Salisbury, Mara G Coyle, Gabriele Fischer, Peter R Martin, Susan Stine, Hendrée E Jones
BACKGROUND: Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy. However, the literature on the relationship between longer-term effects of prenatal exposure to these medications and childhood development is both spare and inconsistent. METHODS: Participants were 96 children and their mothers who participated in MOTHER, a randomized controlled trial of opioid-agonist pharmacotherapy during pregnancy. The present study examined child growth parameters, cognition, language abilities, sensory processing, and temperament from 0 to 36 months of the child's life...
February 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29394214/nmda-receptor-antagonism-in-pediatric-pancreatitis-use-of-ketamine-and-methadone-in-a-teenager-with-refractory-pain
#11
Daniel J Mulder, Mary E Sherlock, David L Lysecki
No abstract text is available yet for this article.
February 1, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29393208/methadone-dose-adjustments-plasma-r-methadone-levels-and-therapeutic-outcome-of-heroin-users-a-randomized-clinical-trial
#12
Guido Mannaioni, Cecilia Lanzi, Michela Lotti, Valentina Galli, Arianna Totti, Ilaria Pacileo, Maria Sili, Chiara Pracucci, Arianna Dilaghi, Lara Bertieri, Mariarita Quaranta, Francesco Orsini, Brunella Occupati, Assia Michahelles, Riccardo Ciuti, Elisa Bianchini, Giancarlo Fabbro, Annibale Biggeri, Emanuela Masini, Flavio Moroni
AIMS: We aimed to improve the retention in treatment and therapeutic outcome of methadone maintenance treatment (MMT) patients by adjusting the oral methadone dose in order to reach a "target" plasma R-methadone level (80-250 ng/mL). METHODS: A multicenter randomized controlled trial was organized. RESULTS: The intention-to-treat statistical analysis showed that repeated dose adjustments performed in order to obtain therapeutic plasma R-methadone levels did not improve retention in treatment of heroin-dependent patients...
January 31, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29389213/tobacco-withdrawal-among-opioid-dependent-smokers
#13
Joanna M Streck, Sarah H Heil, Stephen T Higgins, Janice Y Bunn, Stacey C Sigmon
Prevalence of cigarette smoking among opioid-dependent individuals is 6-fold that of the general U.S. adult population and their quit rates are notoriously poor. One possible reason for the modest cessation outcomes in opioid-dependent smokers may be that they experience more severe tobacco withdrawal upon quitting. In this secondary analysis, we evaluated tobacco withdrawal in opioid-dependent (OD) smokers versus smokers without co-occurring substance use disorders (SUDs). Participants were 47 methadone- or buprenorphine-maintained smokers and 25 non-SUD smokers who completed 1 of several 2-week studies involving daily visits for biochemical monitoring, delivery of financial incentives contingent on smoking abstinence, and assessment of withdrawal via the Minnesota Nicotine Withdrawal Scale (MNWS)...
February 1, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29377736/family-related-factors-and-concurrent-heroin-use-in-methadone-maintenance-treatment-in-china
#14
Nan Feng, Chunqing Lin, Julie Hsieh, Keming Rou, Li Li
BACKGROUND: The use of heroin during Methadone Maintenance Treatment (MMT) is a challenging problem that contributes to poor treatment outcomes. Families may play an important role in addressing concurrent heroin use during MMT, especially in collectivist societies such as China. OBJECTIVES: In this study, we explored the relationship between family-related factors and concurrent heroin use during MMT in China. METHODS: This study was conducted at 68 MMT clinics in five provinces of China...
January 29, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29372946/self-harm-methadone-use-and-drug-related-deaths-amongst-those-registered-as-being-of-no-fixed-abode-or-homeless-in-ireland
#15
R W Glynn, E Lynn, E Griffin, M Fitzgerald, M Ward
This work aims to contribute to the evidence base regarding the health of those who experience homelessness in Ireland by collating data on methadone use, drug-related deaths and emergency department presentations due to self-harm. Data from the Central Methadone Treatment List (CTL), National Self-Harm Registry Ireland and the National Drug-Related Deaths Index were analysed. The percentage on the CTL registered as being of no fixed abode (NFA) or homeless increased from 2% to 7% from 2011-2014. The absolute number of presentations with deliberate self-harm from those of NFA increased by 49% from 2007-2014...
September 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29372750/the-role-of-preterm-birth-in-the-association-between-opioid-maintenance-therapy-and-neonatal-abstinence-syndrome
#16
Lara S Lemon, Ashley Naimi, Steve N Caritis, Robert W Platt, Raman Venkataramanan, Lisa M Bodnar
BACKGROUND: Pregnant women treated with methadone as opioid maintenance therapy are more likely than women treated with buprenorphine to deliver preterm. Preterm birth is associated with less risk of neonatal abstinence syndrome (NAS). We sought to assess the role of preterm birth as a mediator of the relationship between in utero exposure to methadone and NAS compared with buprenorphine. METHODS: We studied 716 women receiving methadone or buprenorphine and delivering liveborn infants at Magee-Womens Hospital, Pittsburgh, Pennsylvania (2013-15)...
January 26, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29333880/pharmacogenetic-analysis-of-opioid-dependence-treatment-dose-and-dropout-rate
#17
Richard C Crist, James Li, Glenn A Doyle, Alex Gilbert, Bryan M Dechairo, Wade H Berrettini
BACKGROUND: Currently, no pharmacogenetic tests for selecting an opioid-dependence pharmacotherapy have been approved by the US Food and Drug Administration. OBJECTIVES: Determine the effects of variants in 11 genes on dropout rate and dose in patients receiving methadone or buprenorphine/naloxone (ClinicalTrials.gov Identifier: NCT00315341). METHODS: Variants in six pharmacokinetic genes (CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4) and five pharmacodynamic genes (HTR2A, OPRM1, ADRA2A, COMT, SLC6A4) were genotyped in samples from a 24-week, randomized, open-label trial of methadone and buprenorphine/naloxone for the treatment of opioid dependence (n = 764; 68...
January 15, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29333821/opioid-treatment-for-mixed-pain-in-pediatric-patients-assisted-by-the-palliative-care-team-five-years-of-experience
#18
María L Yazde Puleio, Karina V Gómez, Ana Majdalani, Vilma Pigliapoco, Gisella Santos Chocler
Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Depending on its pathophysiological mechanism, it may be classified into nociceptive, neuropathic, and mixed pain. If pain is moderate to severe, a strong opioid should be administered and, when this is the case, morphine is the drug of choice. If morphine is ineffective or causes intolerable adverse effects, opioid rotation is recommended. Our objective was to describe the drug management for mixed pain used in patients assisted by the Palliative Care team of Hospital General de Niños Pedro de Elizalde between August 2011 and September 2015...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29330156/application-of-receptor-theory-to-the-design-and-use-of-fixed-proportion-mu-opioid-agonist-and-antagonist-mixtures-in-rhesus-monkeys
#19
Jeremy C Cornelissen, Samuel Obeng, Kenner C Rice, Yan Zhang, S Stevens Negus, Matthew Banks
Receptor theory predicts that fixed-proportion mixtures of a competitive, reversible agonist (e.g. fentanyl) and antagonist (e.g. naltrexone) at a common receptor (e.g. mu opioid receptors; MOR) will result in antagonist proportion-dependent decreases in apparent efficacy of the mixtures and downward shifts in mixture dose-effect functions. The present study tested this hypothesis by evaluating behavioral effects of fixed-proportion fentanyl/naltrexone mixtures in a warm-water tail-withdrawal procedure in rhesus monkeys (n=4)...
January 12, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29325708/promising-roles-for-pharmacists-in-addressing-the-u-s-opioid-crisis
#20
Wilson M Compton, Christopher M Jones, Jack B Stein, Eric M Wargo
Overdoses of prescription or illicit opioids claimed the lives of 116 Americans each day in 2016, and the crisis continues to escalate. As healthcare systems evolve to address the crisis, the potential of pharmacists to make a positive difference is significant. In addition to utilizing available prescription drug monitoring programs to help prevent diversion of opioids, practicing pharmacists can be alert for signs of opioid misuse by patients (e.g., multiple prescriptions from different physicians) as well as inappropriate prescribing or hazardous drug combinations that physicians may not be aware of (e...
December 31, 2017: Research in Social & Administrative Pharmacy: RSAP
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