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https://www.readbyqxmd.com/read/28738589/2-aminopurine-probe-in-combination-with-catalyzed-hairpin-assembly-signal-amplification-for-simple-and-sensitive-detection-of-microrna
#1
Chan Liu, Sifang Lv, Hang Gong, Chunyan Chen, Xiaoming Chen, Changqun Cai
A quencher-free and enzyme-free fluorescent sensor was proposed to simply and sensitively detect miRNA via the target catalyzed hairpin assembly (CHA) signal amplification in combination with 2-aminopurine (2-AP) molecular beacon (MBs). This sensor contains two DNA hairpins termed as H1 and H2. H1 labeled by 2-AP needs no quenchers because 2-AP can be quenched through its stacking interaction with the adjacent bases. H2 is partially complementary to H1. In the presence of the target microRNA (miRNA), H1 is unfolded and produces the DNA/RNA complexes, enhancing the fluorescent signal...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738566/preparation-and-evaluation-of-a-novel-n-benzyl-phenethylamino-%C3%AE-cyclodextrin-bonded-chiral-stationary-phase-for-hplc
#2
Liang Li, Biaoping Cheng, Rendan Zhou, Zhigang Cao, Chun Zeng, Laisheng Li
A novel N-benzyl-phenethylamino-β-cyclodextrin-bonded ordered mesoporous SBA-15 chiral stationary phase (BZCDP) for high-performance liquid chromatography (HPLC) was prepared. The structure and morphology of the ligand and the stationary phase were characterized by mass spectrometry, elemental analysis, infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and thermogravimetric analysis. The enantiomers of chiral compounds including nine common β-adrenergic blocker drugs (β-blockers), eight dansyl amino acids (DNS-AA) and six flavanones were successfully separated by polar organic solvent and reversed-phase chromatography, respectively...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738231/sliding-strip-microfluidic-device-enables-elisa-on-paper
#3
Mohit S Verma, Maria-Nefeli Tsaloglou, Tyler Sisley, Dionysios Christodouleas, Austin Chen, Jonathan Milette, George M Whitesides
This article describes a 3D microfluidic paper-based analytical device that can be used to conduct an enzyme-linked immunosorbent assay (ELISA). The device comprises two parts: a sliding strip (which contains the active sensing area) and a structure surrounding the sliding strip (which holds stored reagents-buffers, antibodies, and enzymatic substrate-and distributes fluid). Running an ELISA involves adding sample (e.g. blood) and water, moving the sliding strip at scheduled times, and analyzing the resulting color in the sensing area visually or using a flatbed scanner...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28737291/nucleoside-reverse-transcriptase-inhibitor-reducing-strategies-in-hiv-treatment-assessing-the-evidence
#4
REVIEW
C Orkin, J M Llibre, S Gallien, A Antinori, Gmn Behrens, A Carr
Antiretroviral (ARV) therapy, comprising a backbone of two nucleos(t)ide reverse transcriptase inhibitors (NRTIs) plus another ARV, is the recognized standard of care (SOC), which has helped extend life expectancy in people living with HIV. In a quest to reduce lifelong drug exposure and minimize or avoid the toxicity of NRTIs, "NRTI-reducing" regimens have been investigated. This descriptive review assessing the results of NRTI-reducing strategies from the largest randomized trials focuses on virological efficacy, resistance, regimen safety (in terms of bone mineral density, renal function, lipids and central nervous system function) and simplicity...
July 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28736505/estimating-the-cost-effectiveness-of-daclatasvir%C3%A2-%C3%A2-sofosbuvir-versus-sofosbuvir%C3%A2-%C3%A2-ribavirin-for-patients-with-genotype-3-hepatitis-c-virus
#5
Phil McEwan, Samantha Webster, Thomas Ward, Michael Brenner, Anupama Kalsekar, Yong Yuan
BACKGROUND: As treatments for chronic hepatitis C are moving away from interferon-containing regimens, the most appropriate allocation of resources to higher cost, interferon-free, direct-acting antiviral (DAA) regimens needs to be assessed. Hepatitis C virus (HCV) genotype 3 is associated with faster disease progression and has fewer treatment options, historically, than other HCV genotypes. This analysis aims to estimate the comparative cost-effectiveness of two recently licenced interferon-free regimens for the treatment of HCV genotype 3...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28735577/growth-performance-and-digestion-of-growing-lambs-fed-diets-supplemented-with-glycerol
#6
A M Saleem, A M Singer
Two experiments were conducted to evaluate the effects of replacing corn with an increasing concentration of high-purity glycerol (>99%) on growth performance, economical efficiency, blood constituents and nutrient digestibility of growing lambs. In experiment one, 24 male lambs (initial BW=33.6±6.0 kg; age=6.75±0.75 months) were randomly assigned to one of the three experimental treatments containing 0%, 5% or 10% glycerol to replace corn in concentrate. In experiment two, nine lambs (initial BW=44.7±2...
July 24, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28735451/importance-of-icpms-for-speciation-analysis-is-changing-future-trends-for-targeted-and-non-targeted-element-speciation-analysis
#7
Joerg Feldmann, Andrea Raab, Eva M Krupp
This article is aimed at researchers interested in organic molecules which contain a heteroatom but who have never considered using inductively coupled plasma mass spectrometry (ICPMS) or who have used ICPMS for years and developed numerous methods for analysis of target elemental species. We try to illustrate (1) that ICPMS has been very useful for speciation analysis of metal(loid) target species and that there is now a trend to replace the costly detector with cheaper detection systems for routine target analysis, and (2) that ICPMS has been used and will be used even more in the future for non-targeted analysis of elements which are not normally associated with ICPMS analysis, such as non-metals such as sulfur, phosphorus, chlorine and fluorine...
July 22, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28735207/nutrient-balancing-for-phytoremediation-enhancement-of-urea-manufacturing-raw-wastewater
#8
Sara Yavari, Amirhossein Malakahmad, Nasiman B Sapari, Saba Yavari, Eakalak Khan
Application of urea manufacturing wastewater to teak (Tectona grandis) trees, a fast growing tropical timber plants, is an environmentally-friendly and cost-effective alternative for treatment of nitrogen-rich wastewater. However, the plant growth is strongly limited by lack of phosphorus (P) and potassium (K) elements when the plants are irrigated with wastewater containing high concentration of nitrogen (N). A greenhouse experiment was conducted to optimize the efficiency of teak-based remediation systems in terms of nutrient balance...
July 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28734109/the-cost-of-oropharyngeal-cancer-in-england-a-retrospective-hospital-data-analysis
#9
Sam T Keeping, Michael J Tempest, Stephanie J Stephens, Stuart M Carroll, Richard Simcock, Terence M Jones, Richard Shaw
OBJECTIVES: To estimate the total costs of treating head and neck cancers, specifically oropharyngeal, laryngeal and oral cavity cancer, in secondary care facilities in England during the period 2006/2007 to 2010/2011. DESIGN: Patient records were extracted from an English hospital database to estimate the number of patients treated for oropharyngeal, laryngeal and oral cavity cancer in England. Identified resource use was linked to published United Kingdom cost estimates to quantify the reimbursement of treatment through the Payment by Results system...
July 22, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28733882/prediction-of-the-lowest-charge-transfer-excited-state-energy-at-the-donor-acceptor-interface-in-a-condensed-phase-using-ground-state-dft-calculations-with-generalized-kohn-sham-functionals
#10
Shaohui Zheng, Mengyue Xiao, Yongping Tian, Xue Chen
Knowledge of the charge (electron) transfer process at the donor-acceptor interface is required to understand the working mechanisms of different organic photovoltaic materials. Investigating the lowest charge-transfer state in organic donor-acceptor solar cells is important as it allows the destruction/formation of excitons and polarons to be studied, and is directly related to the open circuit voltage. By performing low-cost and feasible calculations of ground-state electronic structures using the Mulliken rule as well as the optimally tuned range-separated hybrid (OTRSH) density functional and a regular long-range corrected functional, the lowest charge-transfer (CT) state energies of a series of dimers containing functionalized anthracene (the donor) and tetracyanoethylene (the acceptor) were obtained...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28732965/facile-and-cost-effective-preparation-of-pva-modified-calcium-carbonate-nanocomposites-via-ultrasonic-irradiation-application-in-adsorption-of-heavy-metal-and-oxygen-permeation-property
#11
Shadpour Mallakpour, Elham Khadem
This work is focused on the fabrication and determination of physicochemical behaviors of new poly(vinyl alcohol) (PVA) nanocomposites (NCs) containing various contents of calcium carbonate (CC) nanoparticles modified with γ-aminopropyl triethoxy silane (ATS) (henceforth designated as CC-ATS) which could be a crucial treatment for their application as gas barrier to O2 gas and uptake of metal ions in waste waters. Samples were produced through the solution casting method under ultrasound irradiation. Thermal and mechanical performances were also evaluated for all ultrasonically synthesized nanocomposites and the results indicated that thermal and mechanical stability are dramatically enhanced by addition of a small amount of modified CC-ATS within PVA up to 5wt% and higher amounts has low effect on the composite properties...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732956/sonocatalytic-removal-of-ibuprofen-and-sulfamethoxazole-in-the-presence-of-different-fly-ash-sources
#12
Yasir A J Al-Hamadani, Chang Min Park, Lateef N Assi, Kyoung Hoon Chu, Shamia Hoque, Min Jang, Yeomin Yoon, Paul Ziehl
We examined the feasibility of using two types of fly ash (an industrial waste from thermal power plants) as a low-cost catalyst to enhance the ultrasonic (US) degradation of ibuprofen (IBP) and sulfamethoxazole (SMX). Two fly ashes, Belews Creek fly ash (BFA), from a power station in North Carolina, and Wateree Station fly ash (WFA), from a power station in South Carolina, were used. The results showed that >99% removal of IBP and SMX was achieved within 30 and 60min of sonication, respectively, at 580kHz and pH 3...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732847/quaternized-carboxymethyl-chitosan-organic-montmorillonite-nanocomposite-as-a-novel-cosmetic-ingredient-against-skin-aging
#13
Kaihang Chen, Binzhao Guo, Jiwen Luo
It is of technical and economic importance to develop an effective cosmetic ingredient against skin aging through low-cost and facile production. This study developed a polymer/layered silicate nanocomposite as cosmetic ingredient against skin aging. Firstly, quaternized carboxymethyl chitosan (QCMC)/organic montmorillonite (OMMT) nanocomposite (QCOM) was fabricated via solution-induced intercalation. QCOM with different mass ratios of QCMC to OMMT were studied by various characterizations as well as moisture-adsorption and retention activities and UV-protection capacity...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28732452/assessment-of-the-potential-impact-of-dose-rounding-parenteral-chemotherapy-agents-on-cost-savings-and-drug-waste-minimization
#14
Kelly A Chillari, Jessica Southward, Natasha Harrigan
Background Fiscally responsible utilization of anticancer treatments is necessary to combat their continually increasing cost. Dose rounding is one strategy that has been explored to minimize cost and waste without losing clinical effectiveness. Objectives To determine if dose rounding chemotherapy agents is a feasible cost-containment strategy at an institution with a small oncology clinic. Methods This study is a retrospective chart review of all body surface area dosed parenteral chemotherapy prescribed for an oncological diagnosis over a 12-month period (1 October 2015-30 September 2016)...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28732440/intravenous-injection-of-myelin-oligodendrocyte-glycoprotein-coated-plga-microparticles-have-tolerogenic-effects-in-experimental-autoimmune-encephalomyelitis
#15
Mehrdad Gholamzad, Masoumeh Ebtekar, Mehdi Shafiee Ardestani
The abnormal function of the T lymphocytes causes a range of autoimmune diseases, particularly multiple sclerosis; hence, several methods have been used to treat these disorders through the induction of antigen-specific tolerance in T cells. The present study aims to use a simple and low-cost method to produce poly (lactic-co-glycolic acid) (PLGA) nanoparticles for carrying antigens and inducing antigen-specific tolerance. In this study, PLGA nanoparticles were produced using the water/oil/water (W/O/W) method...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28731628/aerial-release-of-rhinoncomimus-latipes-coleoptera-curculionidae-to-control-persicaria-perfoliata-polygonaceae-using-an-unmanned-aerial-system
#16
Yong-Lak Park, Srikanth Gururajan, Harold Thistle, Rakesh Chandran, Richard Reardon
BACKGROUND: Rhinoncomimus latipes (Coleoptera: Curculionidae) is a major biological control agent against the invasive plant, Persicaria perfoliata. Release of R. latipes is challenging with the current visit-and-hand release approach because P. perfoliata shows a high degree of patchiness in the landscape, possesses recurved barbs on its stems, and often spreads into hard-to-access areas. This 3-year study developed and evaluated unmanned aerial systems (UAS) for precise aerial release and survivorship of R...
July 21, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28727871/biosimilars-in-oncology-in-the-united-states-a-review
#17
Chadi Nabhan, Sandeep Parsad, Anthony R Mato, Bruce A Feinberg
Importance: Biosimilars are biological medicines that contain a highly similar version of the active substance of an already approved biologic reference product. The availability of biosimilars might provide an opportunity to lower health care expenditures as a result of the inherent price competition with their reference product. Understanding how biosimilar cancer drugs are regulated, approved, and paid for, as well as their impact in a value-based care environment, is essential for physicians and other stakeholders in oncology...
July 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28727144/density-mediated-indirect-effects-from-active-predators-and-narrow-habitat-domain-prey
#18
S A Rinehart, S C Schroeter, J D Long
The hunting mode-habitat domain range framework suggests that the mechanism driving trophic cascades [i.e. trait-mediated indirect interactions (TMIIs) versus density-mediated indirect interactions (DMIIs)] should depend upon the functional traits of predators and prey. For example, trophic cascades containing active, broad habitat domain range (BHDR) predators interacting with narrow habitat domain range (NHDR) prey are predicted to arise primarily via TMIIs, because these prey should reduce their conspicuous activity in the presence of these predators...
July 20, 2017: Ecology
https://www.readbyqxmd.com/read/28725319/autologous-stromal-vascular-fraction-in-the-intravenous-treatment-of-end-stage-chronic-obstructive-pulmonary-disease-a-phase-i-trial-of-safety-and-tolerability
#19
Kristin Comella, Jesus A Perez Blas, Tom Ichim, Javier Lopez, Jose Limon, Ruben Corral Moreno
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a consistently progressive, ultimately fatal disease for which no treatment exists capable of either reversing or even interrupting its course. It afflicts more than 5% of the population in many countries, and it accordingly represents the third most frequent cause of death in the US, where it accounts for more than 600 billion in health care costs, morbidity, and mortality. Adipose tissue contains within its stromal compartment a high abundance of adipose stem/stromal cells (ASCs), which can be readily separated from the adipocyte population by methods which require less than 2 h of processing time and yield a concentrated cellular preparation termed the stromal vascular fraction (SVF)...
August 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28725268/towards-microalgal-triglycerides-in-the-commodity-markets
#20
Giulia Benvenuti, Jesús Ruiz, Packo P Lamers, Rouke Bosma, René H Wijffels, Maria J Barbosa
BACKGROUND: Microalgal triglycerides (TAGs) hold great promise as sustainable feedstock for commodity industries. However, to determine research priorities and support business decisions, solid techno-economic studies are essential. Here, we present a techno-economic analysis of two-step TAG production (growth reactors are operated in continuous mode such that multiple batch-operated stress reactors are inoculated and harvested sequentially) for a 100-ha plant in southern Spain using vertically stacked tubular photobioreactors...
2017: Biotechnology for Biofuels
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