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https://www.readbyqxmd.com/read/28445403/detection-of-hepatitis-b-virus-m204i-mutation-by-quantum-dot-labeled-dna-probe
#1
Cheng Zhang, Yiping Chen, Xinmiao Liang, Guanhua Zhang, Hong Ma, Leng Nie, Yu Wang
Quantum dots (QDs) are semiconductor nanoparticles with a diameter of less than 10 nm, which have been widely used as fluorescent probes in biochemical analysis and vivo imaging because of their excellent optical properties. Sensitive and convenient detection of hepatitis B virus (HBV) gene mutations is important in clinical diagnosis. Therefore, we developed a sensitive, low-cost and convenient QDs-mediated fluorescent method for the detection of HBV gene mutations in real serum samples from chronic hepatitis B (CHB) patients who had received lamivudine or telbivudine antiviral therapy...
April 26, 2017: Sensors
https://www.readbyqxmd.com/read/28443610/ordered-micro-macro-porous-k-oms-2-sio2-nanocatalysts-facile-synthesis-low-cost-and-high-catalytic-activity-for-diesel-soot-combustion
#2
Xuehua Yu, Zhen Zhao, Yuechang Wei, Jian Liu
A series of novel oxide catalysts, which contain three-dimensionally ordered macroporous (3DOM) and microporous structure, were firstly designed and successfully synthesized by simple method. In the as-prepared catalysts, 3DOM SiO2 is used as support and microporous K-OMS-2 oxide nanoparticles are supported on the wall of SiO2. 3DOM K-OMS-2/SiO2 oxide catalysts were firstly used in soot particle oxidation reaction and they show very high catalytic activities. The high activities of K-OMS-2/SiO2 oxide catalysts can be assigned to three possible reasons: macroporous effect of 3DOM structure for improving contact between soot and catalyst, microporous effect of K-OMS-2 for adsorption of small gas molecules and interaction of K and Mn for activation of gas molecules...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28443247/evaluation-of-a-new-ifn-%C3%AE-release-assay-for-rapid-diagnosis-of-active-tuberculosis-in-a-high-incidence-setting
#3
Gen Li, Feng Li, Hui-Min Zhao, Han-Li Wen, Hai-Cong Li, Chun-Ling Li, Ping Ji, Peng Xu, Kang Wu, Zhi-Dong Hu, Shui-Hua Lu, Douglas B Lowrie, Jian-Xin Lv, Xiao-Yong Fan
Blood-based interferon-gamma (IFN-γ) release assays (IGRAs) have been proven to be useful in the diagnosis of Mycobacterium tuberculosis (Mtb) infection. However, IGRAs have not been recommended for clinical practice in most low-income settings due to cost-intensive limitations and shortage of clinical data available. The established T-SPOT. TB assay containing Mtb-specific antigens ESAT-6 and CFP10 are widely used for immunodiagonsis of Mtb infection, but the high cost is one of the restricting factors against its clinical application in the developing countries...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28442388/microbial-secretion-of-lactate-enriched-oligomers-for-efficient-conversion-into-lactide-a-biological-shortcut-to-polylactide
#4
Camila Utsunomia, Ken'ichiro Matsumoto, Sakiko Date, Chiaki Hori, Seiichi Taguchi
Recently, we have succeeded in establishing the microbial platform for the secretion of lactate (LA)-based oligomers (D-LAOs), which consist of D-LA and d-3-hydroxybutyrate (d-3HB). The secretory production of D-LAOs was substantially enhanced by the supplementation of diethylene glycol (DEG), which resulted in the generation of DEG-capped oligomers at the carboxyl terminal (referred as D-LAOs-DEG). The microbial D-LAOs should be key compounds for the synthesis of lactide, an important intermediate for polylactides (PLAs) production, eliminating the costly chemo-oligomerization step in the PLA production process...
April 22, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28442105/towards-development-of-a-universal-dengue-vaccine-how-close-are-we
#5
REVIEW
Ee Leen Pang, Hwei-San Loh
Dengue has been ranked as one of the top emerging diseases in Asia and Latin America. Current epidemiological data may not even reflect the true burden of disease due to under-reported figures. Vector control programmes have failed to contain the disease and worst of all, no specific treatment is available at the moment. Thereby, this pushes the demand for a dengue vaccine as a long-term protective approach. Despite there are numerous vaccine candidates ahead, they could be held back by different aspects in promoting vaccine implementation...
March 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28442007/evaluation-of-b-cereus-mtcc-25641-for-the-treatment-of-dairy-waste-effluent
#6
Kunal Gawai, Kanchan Mogha, Jashbhai Prajapati
  Dairy is one of the industries producing wastewater rich in organic matter and thus leading to creation of odorous and high COD containing effluent. Biotreatment leading to bioconversion of the waste materials is probably the most cost-effective technique for managing and utilizing waste. A pilot-scale aerobic treatment plant showing air pressure of 6 kg/cm3 was designed keeping all the conditions similar to the main aerobic plant of any dairy plant. The COD (Chemical Oxygen Demand) of the control effluent i...
May 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28440533/nationwide-trends-in-inpatient-admissions-of-pulmonary-hypertension-in-the-united-states-from-2000-to-2013
#7
Rutuja R Sikachi, Sonu Sahni, Dhruv Mehta, Abhishek Agarwal, Abhinav Agrawal
INTRODUCTION: Pulmonary hypertension (PH) is a disorder of the pulmonary vasculature with high mortality and bears a large economic burden on the healthcare system. We conducted a review of the largest inpatient database in the United States and analyzed the trends in hospitalizations due to PH from the turn of the century (2000) to 2013 to evaluate the rate of hospitalizations and determine the cost and mortality associated with PH. MATERIAL AND METHODS: We analyzed the National Inpatient Sample Database (NIS) for all patients in which PH (Primary or Secondary) or cor pulmonale was the primary discharge diagnosis (ICD-9: 416...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28439140/are-pharmacists-participating-in-postdischarge-patient-reminders
#8
Bill G Felkey, Brent I Fox
In this column, we are making a short revisit to the technology that can assist in satisfaction of Meaningful Use criteria and can assist health systems that are increasing their population health initiatives to help improve outcomes while containing costs.
March 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28439133/importance-of-pharmacy-involvement-in-the-treatment-of-sepsis
#9
Joseph B Cavanaugh, Jesse B Sullivan, Nicole East, Jessica N Nodzon
Purpose: A review of the impact of pharmacists on appropriate medication selection, timing of administration, and as members of a multidisciplinary sepsis response team. Summary: Early goal-directed therapy (EGDT), currently recommended by the 2013 Surviving Sepsis Campaign guidelines for the management of patients with sepsis, includes the administration of appropriate antibiotics in patients with septic shock within the first hour. Multidisciplinary teams containing pharmacists have been shown to decrease time to antibiotic delivery, time to antibiotic administration, and patient mortality...
March 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28438316/multiple-modes-of-capillary-electrophoresis-applied-in-peptide-nucleic-acid-related-study
#10
Xiaoqian Wang, Youhao Hu, Feng Qu, Rizwan Ullah Khan
Peptide Nucleic Acid (PNA) is a nucleic acid analogue, whose neutrally charged and hydrophobic backbone makes it more stable in vivo, so it might act as a potentially better protein probe as compared to aptamer. Currently the investigation of PNA and protein interaction is scarce. In this research, multiple modes of capillary electrophoresis were established and applied for PNA characterization and its interaction with ssDNA and protein. A 15-mer PNA having the same nucleobase sequence as 15-mer anti-thrombin DNA aptamer was chosen as PNA model for this study, its pI (7...
April 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28438122/comprehensive-performance-comparison-of-high-resolution-array-platforms-for-genome-wide-copy-number-variation-cnv-analysis-in-humans
#11
Rajini R Haraksingh, Alexej Abyzov, Alexander Eckehart Urban
BACKGROUND: High-resolution microarray technology is routinely used in basic research and clinical practice to efficiently detect copy number variants (CNVs) across the entire human genome. A new generation of arrays combining high probe densities with optimized designs will comprise essential tools for genome analysis in the coming years. We systematically compared the genome-wide CNV detection power of all 17 available array designs from the Affymetrix, Agilent, and Illumina platforms by hybridizing the well-characterized genome of 1000 Genomes Project subject NA12878 to all arrays, and performing data analysis using both manufacturer-recommended and platform-independent software...
April 24, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#12
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28437129/acute-ankle-sprain-in-a-mouse-model-changes-in-knee-joint-space
#13
Tricia Hubbard-Turner, Erik A Wikstrom, Sophie Guderian, Michael J Turner
CONTEXT:   Ankle sprains remain the most common orthopaedic injury. Conducting long-term studies in humans is difficult and costly, so the long-term consequences of an ankle sprain are not entirely known. OBJECTIVE:   To measure knee-joint space after a single surgically induced ankle sprain in mice. DESIGN:   Randomized controlled trial. SETTING:   University research laboratory. PATIENTS OR OTHER PARTICIPANTS:   Thirty male mice (CBA/2J) were randomly placed into 1 of 3 surgical groups: the transected calcaneofibular ligament (CFL) group, the transected anterior talofibular ligament/CFL group, and a sham treatment group...
April 24, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28437002/dentists-restorative-decision-making-and-implications-for-an-amalgamless-profession-part-4-clinical-factors
#14
G Alexander, Hopcraft, M J Tyas, R H K Wong
BACKGROUND: The Minamata Convention embodies a world-wide reduction in the production and use of mercury and mercury-containing products and processes, including a phase-down of dental amalgam. This will change the approach to the use of direct restorative materials in the near future. There is little research as to the influence of clinical factors on dentists' decision-making which may be of use when determining the impact of any change. METHODS: An online survey relating to aspects of and attitudes to the use of direct restorative materials was distributed to all dentists who were members of the Australian Dental Association and/or Members or Fellows of the Royal Australasian College of Dental Surgeons...
April 24, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28436902/learning-to-predict-consequences-as-a-method-of-knowledge-transfer-in-reinforcement-learning
#15
Eric Chalmers, Edgar Bermudez Contreras, Brandon Robertson, Artur Luczak, Aaron Gruber
The reinforcement learning (RL) paradigm allows agents to solve tasks through trial-and-error learning. To be capable of efficient, long-term learning, RL agents should be able to apply knowledge gained in the past to new tasks they may encounter in the future. The ability to predict actions' consequences may facilitate such knowledge transfer. We consider here domains where an RL agent has access to two kinds of information: agent-centric information with constant semantics across tasks, and environment-centric information, which is necessary to solve the task, but with semantics that differ between tasks...
April 17, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28436824/efficient-treatment-of-aniline-containing-wastewater-in-bipolar-membrane-microbial-electrolysis-cell-fenton-system
#16
Xiaohu Li, Xiangdan Jin, Nannan Zhao, Irini Angelidaki, Yifeng Zhang
Aniline-containing wastewater can cause significant environmental problems and threaten the humans's life. However, rapid degradation of aniline with cost-efficient methods remains a challenge. In this work, a novel microbial electrolysis cell with bipolar membrane was integrated with Fenton reaction (MEC-Fenton) for efficient treatment of real wastewater containing a high concentration (4460 ± 52 mg L(-1)) of aniline. In this system, H2O2 was in situ electro-synthesized from O2 reduction on the graphite cathode and was simultaneously used as source of OH for the oxidation of aniline wastewater under an acidic condition maintained by the bipolar membrane...
April 19, 2017: Water Research
https://www.readbyqxmd.com/read/28436522/integrated-hydrogen-evolution-and-water-cleaning-via-a-robust-graphene-supported-noble-metal-free-fe1-xcoxs2-system
#17
Yingying Fan, Dandan Wang, Dongxue Han, Yingming Ma, Shuang Ni, Zhonghui Sun, Xiandui Dong, Li Niu
In an electrocatalytic hydrogen evolution reaction (HER) system, a cathodic H(+) resource, an anodic sacrificial agent and a robust catalyst are three essential factors. Industry wastewater emissions, containing high levels of acidity and organic dyes, actually can satisfy the material requirements for the HER. Herein, a new HER method is proposed, taking acidic ions from wastewater as a cathodic resource to produce H2, while organic dye waste acts as an anodic sacrifice to balance the reaction. In such a way, a sustainable H2 energy source can be generated and clean water is obtained as well...
April 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28436346/development-of-health-technology-assessment-in-romania
#18
Silvia Gabriela Scintee, Marius Ciutan
OBJECTIVES: The aim of this study was to describe and analyze the introduction of health technology (HTA) in Romania. METHODS: Based on a review of the literature and legislative documents and personal experiences and observations, the authors describe, evaluate, and explain the background and evolution of the HTA system. RESULTS: Initiatives to introduce HTA in Romania date from the early 1990s, but real steps were taken only in 2012 when the European Union Directive 2011/24/ on the application of patients' rights in cross-border health care had to be passed into Romanian law...
April 24, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28435375/knowledge-attitude-and-practice-of-pediatricians-regarding-pediatric-liquid-medicaments
#19
K L Girish Babu, Geeta Maruti Doddamani, L R Kumaraswamy Naik
OBJECTIVE: To assess the knowledge, attitude, and practice of pediatricians regarding pediatric liquid medicaments (PLMs) and its effect on dental health. MATERIALS AND METHODS: A convenience sample of 103 pediatricians was asked to answer a questionnaire. RESULTS: A total number of 87 pediatricians completed the questionnaires. They considered age and body weight of the child (58%), cost of the medicine (40%), and pharmaceutical company (37%) to be relevant while prescribing...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28434261/strategies-to-prevent-infections-associated-with-cardiovascular-implantable-electronic-devices
#20
Bharath Raj Palraj, Saira Farid, M Rizwan Sohail
Infections involving cardiovascular implantable electronic devices (CIED) are associated with high morbidity and mortality and substantial financial cost. In the past two decades, the rate of CIED infections has increased disproportionate to the number of devices implanted, likely due to aging patient population with multiple comorbidities. Microbial contamination of the generator pocket and or leads by skin flora at the time of implantation is a major mechanism for early CIED infections. Due to resistance to host immune cells and antibiotics caused by biofilm formation, complete removal of the device generator and leads is required to achieve cure...
April 24, 2017: Expert Review of Medical Devices
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