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https://www.readbyqxmd.com/read/28546747/the-direct-and-indirect-costs-of-managing-chronic-obstructive-pulmonary-disease-in-greece
#1
Kyriakos Souliotis, Hara Kousoulakou, Georgios Hillas, Nikos Tzanakis, Michalis Toumbis, Theodoros Vassilakopoulos
OBJECTIVE: COPD is associated with significant economic burden. The objective of this study was to explore the direct and indirect costs associated with COPD and identify the key cost drivers of disease management in Greece. METHODS: A Delphi panel of Greek pulmonologists was conducted, which aimed at eliciting local COPD treatment patterns and resource use. Resource use was translated into costs using official health insurance tariffs and Diagnosis-Related Groups (DRGs)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28545904/reductive-amination-of-ketones-catalyzed-by-whole-cell-biocatalysts-containing-imine-reductases-ireds
#2
Zaira Maugeri, Dörte Rother
The asymmetric reductive amination of ketones represents an elegant and convenient way to obtain chiral amines. Recently, several examples have been reported in which isolated imine reductases (IREDs) have been used for this type of reaction leading to promising results. In this work we focus on the applicability of whole cell biocatalysts (recombinant E.coli cells heterologously overexpressing an IRED) to simplify its preparation and to cut on catalyst production costs. Thirteen IREDs were screened towards six different ketones, using methylamine as amine donor...
May 22, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28545817/pre-screening-of-crude-peptides-in-a-serological-bead-based-suspension-array
#3
Tinka Jelsma, Fimme J van der Wal, Helmi Fijten, Nicolas Dailly, Evert van Dijk, Willie L Loeffen
Most serological assays detect antibody responses in biological samples through affinity of serum antibodies for antigens provided in the assay. Certain antigens, however, may be difficult to produce and/or may contain unwanted epitopes. In these cases, a practical alternative may be the use of peptides as representatives for specific epitopes. Peptides can be obtained after purification in large quantities for a modest price, but screening of a large set of peptides during development may be relatively expensive...
May 22, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28545510/effect-of-bone-marrow-derived-mesenchymal-stem-cells-and-stem-cell-supernatant-on-equine-corneal-wound-healing-in-vitro
#4
Amanda B Sherman, Brian C Gilger, Alix K Berglund, Lauren V Schnabel
BACKGROUND: We aimed to determine and compare the in vitro effects of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and mesenchymal stem cell supernatant (MSC-Sp) on the wound healing capacity of equine corneal fibroblasts using a scratch assay. METHODS: Bone marrow aspirates and eyes were collected from normal, euthanized horses with subsequent isolation and culture of BM-MSCs and corneal stromal cells. Corneal stromal cells were culture-expanded in the culture well of transwell plates and then treated with an autologous BM-MSC suspension (dose: 2...
May 25, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28545430/sustainability-in-health-care-by-allocating-resources-effectively-share-6-investigating-methods-to-identify-prioritise-implement-and-evaluate-disinvestment-projects-in-a-local-healthcare-setting
#5
Claire Harris, Kelly Allen, Vanessa Brooke, Tim Dyer, Cara Waller, Richard King, Wayne Ramsey, Duncan Mortimer
BACKGROUND: This is the sixth in a series of papers reporting Sustainability in Health care by Allocating Resources Effectively (SHARE) in a local healthcare setting. The SHARE program was established to investigate a systematic, integrated, evidence-based approach to disinvestment within a large Australian health service. This paper describes the methods employed in undertaking pilot disinvestment projects. It draws a number of lessons regarding the strengths and weaknesses of these methods; particularly regarding the crucial first step of identifying targets for disinvestment...
May 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28544081/direct-medical-costs-of-severe-hypoglycaemic-events-in-patients-with-type-2-diabetes-in-england-a-retrospective-database-study
#6
Tim Holbrook, Yuexin Tang, Romita Das, R Ravi Shankar, Kaan Tunceli, Jean Williams, Larry Radican, Sarah E Holden, Chris Ll Morgan, James Piercy, Craig J Currie
AIMS: Hypoglycaemia in patients with diabetes can be induced by insulins and sulfonylureas. We assessed the real-world impact of specific monotherapy and combination regimens on hypoglycaemic events requiring hospitalisation and related secondary costs to the English healthcare system. METHODS: This retrospective observational study used the Clinical Practice Research Datalink with linked hospital admission data during 2008-2012. Patients with type 2 diabetes mellitus (T2DM) using antihyperglycaemic agents (AHAs) were assigned to mutually exclusive subgroups (insulin- and non-insulin-containing regimens; treatment groups of interest; age group) based on treatment at index date (date of first AHA prescription)...
May 23, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28541741/green-approach-for-synthesis-of-gold-nanoparticles-from-nigella-arvensis-leaf-extract-and-evaluation-of-their-antibacterial-antioxidant-cytotoxicity-and-catalytic-activities
#7
Azam Chahardoli, Naser Karimi, Fatemeh Sadeghi, Ali Fattahi
In the present work, we studied the reduction of gold ions into gold nanoparticles using Nigella arvensis leaf extract in the one-step green synthesis method. The formation of N. arvensis gold nanoparticles (NA-GNPs) was confirmed by UV-Vis spectroscopy, XRD, FT-IR and TEM analyses. The XRD pattern confirmed the crystal structure of NA-GNPs, and TEM image showed the small size (3-37 nm) and almost spherical shape of NA-GNPs. NA-GNPs have not shown enhanced antioxidant properties compared to the plant extract while they were active against the clinical isolated bacterial strains...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28541682/powerful-thermally-stable-one-pot-preparable-and-recyclable-electrophilic-trifluoromethylating-agents-2-8-difluoro-and-2-3-7-8-tetrafluoro-s-trifluoromethyl-dibenzothiophenium-salts
#8
Teruo Umemoto, Bin Zhang, Tianhao Zhu, Xiaocong Zhou, Peng Zhang, Song Hu, Yuanqiang Li
Although many electrophilic trifluoromethylating agents have been reported to date, practically useful reagents have yet to be developed. S-(Trifluoromethyl)dibenzothiophenium salts, known as Umemoto's reagents, have two significant drawbacks that have hampered their practical application: (1) synthesis involving many steps and (2) the formation of large amounts of dibenzothiophene as waste after trifluoromethylation. Our idea to substitute fluorine at specific positions on the dibenzothiophenium rings has resulted in massive improvements in the synthesis, properties, reactivity, and applications of these compounds...
May 25, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28541463/reducing-surgical-infections-and-implant-costs-via-a-novel-paradigm-of-enhanced-physician-awareness
#9
Nitin Agarwal, Prateek Agarwal, Ashley Querry, Anna Mazurkiewicz, Brittany Whiteside, Oscar C Marroquin, Stephen F Koscumb, Daniel A Wecht, Robert M Friedlander
BACKGROUND: Studies have demonstrated that physicians are often unaware of prescription drug, laboratory, diagnostic, and surgical supply costs. OBJECTIVE: To investigate the effects of increased physician awareness on infection incidence and surgical device cost containment. METHODS: Within our institution, physicians were informed of individual, independently adjudicated, craniotomy and ventricular shunt infection incidence and rankings among peers, after which a protocol aimed at reducing skin bacterial burden was implemented for craniotomies...
May 24, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28541353/pendant-chain-engineering-to-fine-tune-the-nanomorphologies-and-solid-state-luminescence-of-naphthalimide-aieegens-application-to-phenolic-nitro-explosive-detection-in-water
#10
Niranjan Meher, Parameswar Krishnan Iyer
Strategically, a series of five angular "V" shaped naphthalimide AIEEgens with varying pendant chains (butyl, hexyl, octyl, cyclohexyl and methylcyclohexyl) have been synthesized to fine-tune their nanomorphological and photophysical properties. With similar aromatic cores and electronic states, unexpected tuning of the condensed state emission colors and nanomorphologies (reproducible on any kind of surface) of naphthalimides has been achieved for the first time simply by varying their side chains. Conclusive analysis by various spectroscopic techniques (SC-XRD, powder-XRD, DLS, FESEM) and DFT computational studies confirmed the full control of the pendant chain (in terms of bulkiness around the naphthalimide core, which restricts the ease of intermolecular π-π interactions) over the nanoaggregate morphology and solid state emissive properties of the AIEEgens; this can be rationalized to all aggregation-prone systems...
May 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28539115/quad-phased-data-mining-modeling-for-dementia-diagnosis
#11
Sunjoo Bang, Sangjoon Son, Hyunwoong Roh, Jihye Lee, Sungyun Bae, Kyungwon Lee, Changhyung Hong, Hyunjung Shin
BACKGROUND: The number of people with dementia is increasing along with people's ageing trend worldwide. Therefore, there are various researches to improve a dementia diagnosis process in the field of computer-aided diagnosis (CAD) technology. The most significant issue is that the evaluation processes by physician which is based on medical information for patients and questionnaire from their guardians are time consuming, subjective and prone to error. This problem can be solved by an overall data mining modeling, which subsidizes an intuitive decision of clinicians...
May 18, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28537596/unique-physicochemical-and-catalytic-properties-dictated-by-the-b3no2-ring-system
#12
Hidetoshi Noda, Makoto Furutachi, Yasuko Asada, Masakatsu Shibasaki, Naoya Kumagai
The expansion of molecular diversity beyond what nature can produce is a fundamental objective in chemical sciences. Despite the rich chemistry of boron-containing heterocycles, the 1,3-dioxa-5-aza-2,4,6-triborinane (DATB) ring system, which is characterized by a six-membered B3NO2 core, remains elusive. Here, we report the synthesis of m-terphenyl-templated DATB derivatives, displaying high stability and peculiar Lewis acidity arising from the three suitably arranged boron atoms. We identify a particular utility for DATB in the dehydrative amidation of carboxylic acids and amines, a reaction of high academic and industrial importance...
June 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28537336/dietary-risk-factors-by-race-ethnicity-age-group-and-gender-in-a-representative-sample-of-us-older-adults
#13
J A Vaccaro, F G Huffman
OBJECTIVE: To explore the relationships among ethnicity/race, gender, demographics, age-group and dietary health in a nationally representative sample of older adults. DESIGN: Cross-sectional study. SETTING: Data for this study were collected by interview in the mobile examination centers from the National Health and Nutrition Examination Surveys, 2011 - 2012. PARTICIPANTS: U.S. representative sample of adults aged 55 years and older (N = 1860) from five ethnic/racial groups...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28536564/a-metagenomic-approach-to-cyanobacterial-genomics
#14
REVIEW
Danillo O Alvarenga, Marli F Fiore, Alessandro M Varani
Cyanobacteria, or oxyphotobacteria, are primary producers that establish ecological interactions with a wide variety of organisms. Although their associations with eukaryotes have received most attention, interactions with bacterial and archaeal symbionts have also been occurring for billions of years. Due to these associations, obtaining axenic cultures of cyanobacteria is usually difficult, and most isolation efforts result in unicyanobacterial cultures containing a number of associated microbes, hence composing a microbial consortium...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28535985/recalcitrant-deep-and-shallow-nodes-in-aristolochia-aristolochiaceae-illuminated-using-anchored-hybrid-enrichment
#15
Stefan Wanke, Carolina Granados Mendoza, Sebastian Müller, Anna Paizanni Guillén, Christoph Neinhuis, Alan R Lemmon, Emily Moriarty Lemmon, Marie-Stéphanie Samain
Recalcitrant relationships are characterized by very short internodes that can be found among shallow and deep phylogenetic scales all over the tree of life. Adding large amounts of presumably informative sequences, while decreasing systematic error, has been suggested as a possible approach to increase phylogenetic resolution. The development of enrichment strategies, coupled with next generation sequencing, resulted in a cost-effective way to facilitate the reconstruction of recalcitrant relationships. By applying the anchored hybrid enrichment (AHE) genome partitioning strategy to Aristolochia using an angiosperm probe set, we obtained 231 to 233 out of 517 single or low copy nuclear loci originally contained in the enrichment kit, resulting in a total alignment length of 154,756 bp to 160,150 bp...
May 20, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28535886/fluorescent-nanocellulosic-hydrogels-based-on-graphene-quantum-dots-for-sensing-laccase
#16
Celia Ruiz-Palomero, Sandra Benítez-Martínez, M Laura Soriano, Miguel Valcárcel
A novel low-cost fluorimetric platform based on sulfur, nitrogen-codoped graphene quantum dots immersed into nanocellulosic hydrogels is designed and applied in detecting the laccase enzyme. Although most of methods for detecting laccase are based on their catalytic activity, which is strongly dependent on environmental parameters, we report a sensitive and selective method based on the fluorescence response of hydrogels containing graphene quantum dots (GQDs) acting as luminophore towards laccase. The easily-prepared gel matrix not only improves the fluorescence signal of GQDs by avoiding their self-quenching but also stabilizes their fluorescence signal and improves their sensitivity towards laccase...
June 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28535882/versatile-fabrication-of-paper-based-microfluidic-devices-with-high-chemical-resistance-using-scholar-glue-and-magnetic-masks
#17
Thiago M G Cardoso, Fabrício R de Souza, Paulo T Garcia, Denilson Rabelo, Charles S Henry, Wendell K T Coltro
Simple methods have been developed for fabricating microfluidic paper-based analytical devices (μPADs) but few of these devices can be used with organic solvents and/or aqueous solutions containing surfactants. This study describes a simple fabrication strategy for μPADs that uses readily available scholar glue to create the hydrophobic flow barriers that are resistant to surfactants and organic solvents. Microfluidic structures were defined by magnetic masks designed with either neodymium magnets or magnetic sheets to define the patter, and structures were created by spraying an aqueous solution of glue on the paper surface...
June 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28535331/computer-and-mobile-technology-interventions-for-self-management-in-chronic-obstructive-pulmonary-disease
#18
REVIEW
Catherine McCabe, Margaret McCann, Anne Marie Brady
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterised by airflow obstruction due to an abnormal inflammatory response of the lungs to noxious particles or gases, for example, cigarette smoke. The pattern of care for people with moderate to very severe COPD often involves regular lengthy hospital admissions, which result in high healthcare costs and an undesirable effect on quality of life. Research over the past decade has focused on innovative methods for developing enabling and assistive technologies that facilitate patient self-management...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28535094/rheological-and-physical-parameters-correlations-in-formulations-with-pinh%C3%A3-o-derivatives-stability-study-building-up-an-analytical-route
#19
Renata Moschini Daudt, Nilo Sergio Medeiros Cardozo, Ligia Damasceno Ferreira Marczak, Irene Clemes Külkamp Guerreiro
This study focuses on the correlations investigation between rheological and physical parameters and how it can contribute to optimize the topical formulations development. A gel and an emulgel containing pinhão derivatives, and their respective controls, were analyzed along six months of storage. A flowchart of analyses was proposed to use in topical formulation development when a benchmark is the goal or when it is necessary to change some raw material. All formulations were stable over the storage time and the formulations containing pinhão starch and coat extract presented similar properties to those of the control formulations...
May 23, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28534793/an-information-theoretic-cluster-visualization-for-self-organizing-maps
#20
Leonardo Enzo Brito da Silva, Donald C Wunsch
Improved data visualization will be a significant tool to enhance cluster analysis. In this paper, an information-theoretic-based method for cluster visualization using self-organizing maps (SOMs) is presented. The information-theoretic visualization (IT-vis) has the same structure as the unified distance matrix, but instead of depicting Euclidean distances between adjacent neurons, it displays the similarity between the distributions associated with adjacent neurons. Each SOM neuron has an associated subset of the data set whose cardinality controls the granularity of the IT-vis and with which the first- and second-order statistics are computed and used to estimate their probability density functions...
May 17, 2017: IEEE Transactions on Neural Networks and Learning Systems
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