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https://www.readbyqxmd.com/read/29166355/restoring-faculty-vitality-in-academic-medicine-when-burnout-threatens
#1
Darshana T Shah, Valerie N Williams, Luanne E Thorndyke, E Eugene Marsh, Roberta E Sonnino, Steven M Block, Thomas R Viggiano
Increasing rates of burnout-with accompanying stress and lack of engagement-among faculty, residents, students, and practicing physicians have caused alarm in academic medicine. Central to the debate among academic medicine's stakeholders are oft-competing issues of social accountability; cost containment; effectiveness of academic medicine's institutions; faculty recruitment, retention, and satisfaction; increasing expectations for faculty; and mission-based productivity.The authors propose that understanding and fostering what contributes to faculty and institutional vitality is central to preventing burnout during times of change...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29166305/botulinum-toxin-therapy-is-syringe-type-related-to-cost-effectiveness
#2
Mark Anthony Foglietti, Lauren Wright, Alanna Foglietti-Fostyk
INTRODUCTION: Clostridium botulinum toxin is effective through cleaving presynaptic proteins at the neuromuscular junction, which prevents the release of acetylcholine and inhibits muscle contraction. Several serotypes of botulinum toxin (BT) exist; however, only 2 types have been approved by the US Food and Drug Administration for commercial and medical use, A and B. Both types of BT must be administered intramuscularly with a syringe, but the type of syringe is the injector's preference...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29165600/missed-opportunities-to-identify-occupational-asthma-in-acute-secondary-care
#3
P R Ellis, G I Walters
Background: Occupational asthma (OA) accounts for one in six cases of new-onset adult asthma. Despite this it remains under-recognized in the UK. Delayed and missed diagnoses of OA lead to poor health outcomes for workers at significant cost to the UK economy. The burden of occupational aetiology on hospital admissions with asthma is not known. Aims: To measure how frequently medical professionals consider occupational aetiology in patients presenting to secondary care with acute asthma symptoms...
November 18, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29165474/sugar-and-mineral-enriched-fraction-from-olive-mill-wastewater-for-promising-cosmeceutical-application-characterization-in-vitro-and-in-vivo-studies
#4
Maria Domenica Di Mauro, Barbara Tomasello, Roberta Carla Giardina, Sandro Dattilo, Veronica Mazzei, Fulvia Sinatra, Massimo Caruso, Nicola D'Antona, Marcella Renis
Nowadays, agro-food by-products represent a potential low-cost source of biologically active ingredients which have been paid significant attention as nutraceuticals, medicine, food and cosmetics. In a previous study we evaluated the total sugars, metals and polyphenols of olive mill wastewater (OMWW) from a Cerasuola olive cultivar. In the present work we selectively recovered a sugar and mineral enriched fraction (SMEF) from Cerasuola OMWW by a green adsorption/desorption process. The SMEF was mainly found to be composed of monosaccharides and potassium by HPLC-ELSD and ICP-MS...
November 22, 2017: Food & Function
https://www.readbyqxmd.com/read/29165078/pharmaceutical-product-lead-optimization-for-better-in-vivo-bioequivalence-performance-a-case-study-of-diclofenac-sodium-extended-release-matrix-tablets
#5
Aliasgar Shahiwala, Aisha Zarar
BACKGROUND: In order to prove the validity of a new formulation, a considerable amount of efforts is required to study bioequivalence, not only increases the burden of carrying out a number of bioequivalence studies but eventually increase the cost of the optimization process. OBJECTIVE: The aim of the present study was to develop sustained release matrix tablets containing diclofenac sodium using natural polymers and to demonstrate step by step process of product development till the prediction of in vivo marketed product equivalence of the developed product...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29163915/field-deployable-quantitative-rapid-identification-of-active-ebola-virus-infection-in-unprocessed-blood
#6
Kavit Shah, Emma Bentley, Adam Tyler, Kevin S R Richards, Edward Wright, Linda Easterbrook, Diane Lee, Claire Cleaver, Louise Usher, Jane E Burton, James K Pitman, Christine B Bruce, David Edge, Martin Lee, Nelson Nazareth, David A Norwood, Sterghios A Moschos
The West African Ebola virus outbreak underlined the importance of delivering mass diagnostic capability outside the clinical or primary care setting in effectively containing public health emergencies caused by infectious disease. Yet, to date, there is no solution for reliably deploying at the point of need the gold standard diagnostic method, real time quantitative reverse transcription polymerase chain reaction (RT-qPCR), in a laboratory infrastructure-free manner. In this proof of principle work, we demonstrate direct performance of RT-qPCR on fresh blood using far-red fluorophores to resolve fluorogenic signal inhibition and controlled, rapid freeze/thawing to achieve viral genome extraction in a single reaction chamber assay...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29162640/outcomes-of-a-clinical-pathway-to-standardize-use-of-maintenance-intravenous-fluids
#7
Sahar N Rooholamini, Holly Clifton, Wren Haaland, Caitlin McGrath, Surabhi B Vora, Claudia S Crowell, Holly Romero, Jeffrey Foti
OBJECTIVES: Improper use of maintenance intravenous fluids (IVFs) may cause serious hospital-acquired harm. We created an evidence-based clinical pathway to guide providers on the indications for IVF, its preferred composition, and appropriate clinical monitoring. METHODS: Pathway implementation was supported by the creation of an electronic order set (PowerPlan) and hospital-wide education. Outcomes were measured among pathway-eligible patients for the years before (July 1, 2014-June 30, 2015) and after (July 1, 2015-June 30, 2016) implementation...
November 21, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29162040/cloning-and-expression-of-bpmyc4-and-bpbhlh9-genes-and-the-role-of-bpbhlh9-in-triterpenoid-synthesis-in-birch
#8
Jing Yin, Xin Li, Yaguang Zhan, Ying Li, Ziyue Qu, Lu Sun, Siyao Wang, Jie Yang, Jialei Xiao
BACKGROUND: Birch (Betula platyphylla Suk.) contains triterpenoids with anti-HIV and anti-tumor pharmacological activities. However, the natural abundance of these triterpenoids is low, and their chemical synthesis is costly. Transcription factors have the ability to regulate the metabolite pathways of triterpenoids via multi-gene control, thereby improving metabolite yield. Thus, transcription factors have the potential to facilitate the production of birch triterpenoids. Plant bHLH (basic helix-loop-helix) transcription factors play important roles in stress response and secondary metabolism...
November 21, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29161995/carbon-capture-from-natural-gas-using-multi-walled-cnts-based-mixed-matrix-membranes
#9
Abid Hussain, Sarah Farrukh, Arshad Hussain, Muhammad Ayoub
Most of the pure polymers and their blends, utilized in carbon capture membranes are costly but cellulose acetate (CA) being inexpensive, is a lucrative choice. In this research polymeric and mixed matrix membranes (MMMs) have been fabricated to carbon capture from Natural gas. Polyethylene glycol (PEG) has been utilized in the fabrication of these membranes to modify the chain flexibility of polymers which in turn amends the permeability of different gases through these polymers. Whereas multi-wall carbon nanotubes (MWCNTs) provide mechanical strength, thermal stability, an extra free path for CO2 molecules and augment CO2/CH4 selectivity...
November 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29159831/design-and-development-of-low-cost-polyurethane-biopolymer-based-on-castor-oil-and-glycerol-for-biomedical-applications
#10
A C W Tan, B J Polo-Cambronell, E Provaggi, C Ardila-Suárez, G E Ramirez-Caballero, V G Baldovino-Medrano, D M Kalaskar
In the current study, we present the synthesis of novel low cost bio-polyurethane compositions with variable mechanical properties based on castor oil and glycerol for biomedical applications. A detailed investigation of the physicochemical properties of the polymer was carried out by using mechanical testing, ATR-FTIR, and X-ray photoelectron spectroscopy (XPS). Polymers were also tested in short term in-vitro cell culture with human mesenchymal stem cells to evaluate their biocompatibility for potential applications as biomaterial...
November 21, 2017: Biopolymers
https://www.readbyqxmd.com/read/29159790/vitamin-d-supplementation-in-pregnancy-a-survey-of-compliance-with-recommendations
#11
C M Windrim, D A Crosby, K Mitchell, C Brophy, R Mahony, M Higgins
BACKGROUND: Vitamin D deficiency in pregnancy has important maternal and fetal implications, with increased risk of developing gestational diabetes, preeclampsia, preterm birth and small for gestational age birthweight. It is recommended that every pregnant woman should take 5 μg (200 IU) of vitamin D per day during pregnancy and lactation. AIMS: This study aimed to determine the prevalence of women taking vitamin D supplementation and to identify the reasons for patients not taking supplementation within women attending an antenatal clinic in Dublin...
November 20, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29159232/application-of-bi-clustering-of-gene-expression-data-and-gene-set-enrichment-analysis-methods-to-identify-potentially-disease-causing-nanomaterials
#12
Andrew Williams, Sabina Halappanavar
This article contains data related to the research article 'Application of bi-clustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials' (Williams and Halappanavar, 2015) [1]. The presence of diverse types of nanomaterials (NMs) in commerce has grown significantly in the past decade and as a result, human exposure to these materials in the environment is inevitable. The traditional toxicity testing approaches that are reliant on animals are both time- and cost- intensive; employing which, it is not possible to complete the challenging task of safety assessment of NMs currently on the market in a timely manner...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29158151/a-novel-liquid-media-mycobacteria-extraction-method-for-maldi-tof-ms-identification-using-vitek%C3%A2-ms
#13
Erik Moreno, Eric Miller, Elizabeth Miller, Heather Totty, Parampal Deol
A low-cost identification method that can be performed directly from a positive liquid medium culture is needed for the diagnosis of mycobacterial infections. Here, we describe a novel, cost-effective, and validated method that allows for direct and rapid identification of mycobacteria from a positive liquid culture using VITEK® MS with a total process duration under 45min. From a liquid mycobacteria culture a 3.0mL aliquot is removed 24-72h post positivity and centrifuged to create a pellet. After decanting, the tube is blotted dry, the pellet is re-suspended in 0...
November 17, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29157215/integration-of-rna-seq-data-with-heterogeneous-microarray-data-for-breast-cancer-profiling
#14
Daniel Castillo, Juan Manuel Gálvez, Luis Javier Herrera, Belén San Román, Fernando Rojas, Ignacio Rojas
BACKGROUND: Nowadays, many public repositories containing large microarray gene expression datasets are available. However, the problem lies in the fact that microarray technology are less powerful and accurate than more recent Next Generation Sequencing technologies, such as RNA-Seq. In any case, information from microarrays is truthful and robust, thus it can be exploited through the integration of microarray data with RNA-Seq data. Additionally, information extraction and acquisition of large number of samples in RNA-Seq still entails very high costs in terms of time and computational resources...
November 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29156818/a-plasmid-containing-cpg-odn-as-vaccine-adjuvant-against-grass-carp-reovirus-in-grass-carp-ctenopharyngodon-idella
#15
Hang Su, Zhiwei Liao, Gailing Yuan, Jianguo Su
CpG oligodeoxynucleotides (ODNs) are proved to have strong immune stimulatory activity. Plasmids containing CpG ODNs could be conveniently and low-costly used as vaccine adjuvant. However, they are different among various plasmids, motif repeats, species, etc. In the present study, plasmid pcDNA3.1 (+) containing five repetitions of CpG ODN 1670A named pcDNA3.1-1670A*5 with strong immunostimulation was screened out from twelve recombinant plasmids and three empty vectors by cell proliferation activity, interferon promoter activities and immune related gene expressions in CIK cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155724/generation-of-a-gene-disrupted-streptococcus-mutans-strain-without-gene-cloning
#16
Takatoshi Murata, Ayako Okada, Khairul Matin, Nobuhiro Hanada
Typical methods for the elucidation of the function of a particular gene involve comparative phenotypic analyses of the wild-type strain and a strain in which the gene of interest has been disrupted. A gene-disruption DNA construct containing a suitable antibiotic resistance marker gene is useful for the generation of gene-disrupted strains in bacteria. However, conventional construction methods, which require gene cloning steps, involve complex and time-consuming protocols. Here, a relatively facile, rapid, and cost-effective method for targeted gene disruption in Streptococcus mutans is described...
October 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155723/one-step-protocol-for-evaluation-of-the-mode-of-radiation-induced-clonogenic-cell-death-by-fluorescence-microscopy
#17
Daijiro Kobayashi, Atsushi Shibata, Takahiro Oike, Takashi Nakano
Research on ionizing radiation (IR)-induced clonogenic cell death is important for understanding the effect of IR on malignant tumors and normal tissues. Here, we describe a quick and cost-effective one-step assay for simultaneously assessing the major modes of clonogenic cell death induced by IR, i.e., apoptosis, mitotic catastrophe, and cellular senescence. In this method, cells grown on a cover slip are irradiated with X-rays and stained with 4',6-diamidino-2-phenylindole dihydrochloride (DAPI). Using fluorescence microscopy, apoptosis, mitotic catastrophe, and cellular senescence are identified based on the characteristic morphologies of the DAPI-stained nuclei...
October 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29154538/enhanced-removal-of-dissolved-hg-ii-cd-ii-and-au-iii-from-water-by-bacillus-subtilis-bacterial-biomass-containing-an-elevated-concentration-of-sulfhydryl-sites
#18
Qiang Yu, Jeremy B Fein
In this study, the sorption of Hg(II), Cd(II) and Au(III) onto Bacillus subtilis biomass with an elevated concentration of sulfhydryl sites, induced by adding excess glucose to the growth medium (termed 'High Sulfhydryl Bacillus subtilis' or HSBS) was compared to that onto B. subtilis biomass with a low concentration of sulfhydryl sites (termed 'Low Sulfhydryl Bacillus subtilis' or LSBS) and to sorption onto a commercially available cation exchange resin. Our results show that HSBS exhibits sorption capacities for the three studied metals that are two to five times greater than the sorption capacities of LSBS for these metals...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29154093/highly-selective-and-efficient-adsorption-of-hg-2-by-a-recyclable-aminophosphonic-acid-functionalized-polyacrylonitrile-fiber
#19
Gang Xu, Lu Wang, Yujia Xie, Minli Tao, Wenqin Zhang
Mercury ions, even an ultra-trace amount in water, present a serious environmental concern. Hence, searching for cost-effective and high-performance Hg(2+) adsorbents has acquired increasingly attention but still remained challenging. In this work, aminophosphonic acid was immobilized onto polyacrylonitrile fiber by chemical grafting approaches. The functionalized fiber (PANAPF) possessed high adsorption selectivity and efficiency for Hg(2+) when compared with other coexisting ions viz. Pb(2+), Cd(2+), Ag(+), Zn(2+), Cu(2+), Ni(2+), Co(2+), Ca(2+) and Mg(2+)...
November 11, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29153784/an-empirical-comparison-of-isolate-based-and-sample-based-definitions-of-antimicrobial-resistance-and-their-effect-on-estimates-of-prevalence
#20
R W Humphry, J Evans, C Webster, S C Tongue, G T Innocent, G J Gunn
Antimicrobial resistance is primarily a problem in human medicine but there are unquantified links of transmission in both directions between animal and human populations. Quantitative assessment of the costs and benefits of reduced antimicrobial usage in livestock requires robust quantification of transmission of resistance between animals, the environment and the human population. This in turn requires appropriate measurement of resistance. To tackle this we selected two different methods for determining whether a sample is resistant - one based on screening a sample, the other on testing individual isolates...
November 10, 2017: Preventive Veterinary Medicine
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