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https://www.readbyqxmd.com/read/27920887/preliminary-study-on-cost-effective-l-tryptophan-production-from-indole-and-l-serine-by-e-coli-cells
#1
Tahereh Sadeghiyan-Rizi, Jamshid Fooladi, Sima Sadrai
BACKGROUND: L-tryptophan is used widespread in the pharmaceutical industry. The majority of L-Trp production depends on microbial processes that produce L-tryptophan from indole and L-serine. These processes are very costly due to the costs of precursors, especially L-serine. Use of inexpensive substitutions as the L-serine source of L-tryptophan production enables us to reach a cost-effective process. In this paper, effect of Triton X-100 on L-Trp production and the ability to use Iranian cane molasses as inexpensive L-serine source was investigated...
October 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27918644/self-assembled-supramolecular-nanogels-as-a-safe-and-effective-drug-delivery-vector-for-cancer-therapy
#2
Chih-Chia Cheng, Mei-Chih Liang, Zhi-Sheng Liao, Jyun-Jie Huang, Duu-Jong Lee
Simple construction and manipulation of low-molecular-weight supramolecular nanogels, based on the introduction of multiple hydrogen bonding interactions, with the desired physical properties to achieve effective and safe delivery of drugs for cancer therapy remain highly challenging. Herein, a novel supramolecular oligomer cytosine (Cy)-polypropylene glycol containing self-complementary multiple hydrogen-bonded Cy moieties is developed, which undergoes spontaneous self-assembly to form nanosized particles in an aqueous environment...
December 5, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27917719/prevention-and-treatment-of-postoperative-endophthalmitis-using-povidone-iodine
#3
Hiroyuki Shimada, Hiroyuki Nakashizuka, Andrzej Grzybowski
Postoperative endophthalmitis is typically caused by patient's conjunctival bacterial flora or contaminated solutions and instruments. Visual outcome is often poor in severe cases, and treatment is especially difficult when endophthalmitis is caused by multidrug resistant bacteria. Povidone-iodine is used worldwide due to its wide-spectrum antimicrobial activity, absence of resistant bacteria to povidone-iodine, and low cost. Furthermore, the effective concentration against microorganisms and safe concentration for ocular tissues have been well established...
December 4, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27917369/management-of-multiple-myeloma-and-usage-of-bortezomib-perspective-from-india-and-ukraine
#4
Amit Garg, Mykhaylo Morgunskyy, Yogesh Belagali, Namita Gupta, Shyam Prasad Akku
Novel treatment strategies have remarkably improved the multiple myeloma (MM) patients' survival, with associated increased costs. A joint panel meet of international experts from India and Ukraine was held in New Delhi on May 19, 2016 focusing on MM management, bortezomib role, unmet medical needs, and current challenges. The health-care system for oncology in India is majorly private vs. government-based in Ukraine. In India, electrophoresis, serum-free light chain assays, bone marrow tests, and X-rays are available modes of diagnosis...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27916817/real-time-classification-of-patients-with-balance-disorders-vs-normal-subjects-using-a-low-cost-small-wireless-wearable-gait-sensor
#5
Bhargava Teja Nukala, Taro Nakano, Amanda Rodriguez, Jerry Tsay, Jerry Lopez, Tam Q Nguyen, Steven Zupancic, Donald Y C Lie
Gait analysis using wearable wireless sensors can be an economical, convenient and effective way to provide diagnostic and clinical information for various health-related issues. In this work, our custom designed low-cost wireless gait analysis sensor that contains a basic inertial measurement unit (IMU) was used to collect the gait data for four patients diagnosed with balance disorders and additionally three normal subjects, each performing the Dynamic Gait Index (DGI) tests while wearing the custom wireless gait analysis sensor (WGAS)...
November 29, 2016: Biosensors
https://www.readbyqxmd.com/read/27915018/design-and-surface-immobilization-of-short-anti-biofilm-peptides
#6
Biswajit Mishra, Tamara Lushnikova, Radha M Golla, Xiuqing Wang, Guangshun Wang
: Short antimicrobial peptides are essential to keep us healthy and their lasting potency can inspire the design of new types of antibiotics. This study reports the design of a family of eight-residue tryptophan-rich peptides (TetraF2W) obtained by converting the four phenylalanines in temporin-SHf to tryptophans. The temporin-SHf template was identified from the antimicrobial peptide database (http://aps.unmc.edu/AP). Remarkably, the double arginine variant (TetraF2W-RR) was more effective in killing methicillin-resistant Staphylococcus aureus (MRSA) USA300, but less cytotoxic to human skin HaCat and kidney HEK293 cells, than the lysine-containing dibasic combinations (KR, RK and KK)...
November 30, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27913318/walsh-hadamard-based-3d-steganography-for-protecting-sensitive-information-in-point-of-care
#7
Alsharif Abuadbba, Ibrahim Khalil
Remote points-of-care has recently had a lot of attention for their advantages such as saving lives and cost reduction. The transmitted streams usually contain (1) normal biomedical signals (e.g. ECG) and (2) highly private information (e.g. patient identity). Despite the obvious advantages, the primary concerns are privacy and authenticity of the transferred data. Therefore, this paper introduces a novel steganographic mechanism that ensures (1) strong privacy preservation of private information by random concealing inside the transferred signals employing a key, and (2) evidence of originality for the biomedical signals...
November 29, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27912857/homelessness-and-aging-the-contradictory-ordering-of-house-and-home
#8
Amanda Grenier, Rachel Barken, Colleen McGrath
The concepts of 'house' and 'home' are compelling and contradictory. They are compelling because they elicit the desired sentiments of permanence, feeling 'at home', and maintaining continuity in one's life. At the same time, they can be experienced as contradictory where organizational practices and the socio-cultural imperatives of individual responsibility, cost containment, and rationed services are concerned. Where 'house' tends to evoke a sense of permanent stability, 'home' is regarded as the ideal living environment and site of care for older people...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27911610/successful-consecutive-expansion-of-limbal-explants-using-a-biosafe-culture-medium-under-feeder-layer-free-conditions
#9
Marina López-Paniagua, Teresa Nieto-Miguel, Ana de la Mata, Sara Galindo, José M Herreras, Rosa M Corrales, Margarita Calonge
PURPOSE: Transplantation of in vitro cultured limbal epithelial stem cells (LESCs) is a treatment widely used for LESC deficiency. However, the number of limbal tissue donors is limited, and protocols for LESC cultivation often include compounds and/or feeder layers that can induce side effects and/or increase the cost of the culture procedure. We investigated the feasibility of obtaining more than one limbal primary culture (LPC) from the same biopsy using a culture medium in which several potentially harmful compounds were replaced at the same time by biosafe supplements, allowing the LESC cultivation without feeder layers...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27911404/using-capillary-electrophoresis-to-quantify-organic-acids-from-plant-tissue-a-test-case-examining-coffea-arabica-seeds
#10
Michael Joe Vaughan, Ann Chanon, Joshua J Blakeslee
Carboxylic acids are organic acids containing one or more terminal carboxyl (COOH) functional groups. Short chain carboxylic acids (SCCAs; carboxylic acids containing three to six carbons), such as malate and citrate, are critical to the proper functioning of many biological systems, where they function in cellular respiration and can serve as indicators of cell health. In foods, organic acid content can have significant impact on taste, with increased SCCA levels resulting in a sour or "acid" taste. Because of this, methods for the rapid analysis of organic acid levels are of particular interest to the food and beverage industries...
November 12, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910981/cu-cdots-nanocorals-as-electrocatalyst-for-highly-efficient-co2-reduction-to-formate
#11
Sijie Guo, Siqi Zhao, Jin Gao, Cheng Zhu, Xiuqin Wu, Yijun Fu, Hui Huang, Yang Liu, Zhenhui Kang
Electrochemical reduction of CO2 is a key component of many prospective artificial technologies for renewable carbon-containing fuels, but it still suffers from the high overpotentials required to drive the process, low selectivity for diversiform products and the high cost of the catalyst. Here, we report that Cu-CDots nanocorals is a highly efficient, low-cost and stable electrocatalyst for CO2 reduction in aqueous solution. The major product of CO2 reduction on the Cu-CDots nanocorals is HCOOH with an inconceivable low overpotential of 0...
December 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27909613/the-novel-laparoscopic-training-3d-model-in-urology-with-surgical-anatomic-remarks-fresh-frozen-cadaveric-tissue
#12
REVIEW
Emre Huri, Mehmet Ezer, Eddie Chan
Laparoscopic surgery is routinely used to treat many urological conditions and it is the gold standard treatment option for many surgeries such as radical nephrectomy. Due to the difficulty of learning, laparoscopic training should start outside the operating room. Although it is a very different model of laparoscopic training; the aim of this review is to show the value of human cadaveric model for laparoscopic training and present our experience in this area. Fresh frozen cadaveric model in laparoscopic training, dry lab, cadaveric model, animal models and computer based simulators are the most commonly used models for laparoscopic training...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27908774/increased-incorporation-of-gaseous-co2-into-succinate-by-escherichia-coli-overexpressing-carbonic-anhydrase-and-phosphoenolpyruvate-carboxylase-genes
#13
Soohyun Park, Jae-Ung Lee, Sukhyeong Cho, Hyeonsoo Kim, Han Bin Oh, Seung Pil Pack, Jinwon Lee
Carbon dioxide (CO2) is an abundant and cheap carbon source that is partly responsible for global warming in the atmosphere. The objective of this study was to construct a recombinant E. coli strain that can show enhanced production of succinate derived from CO2. In this study, we confirmed the enhancement of utilization by analyzing succinate containing one carbon-13 ((13)C) derived from (13)CO2. Firstly, the carbonic anhydrase gene (SP(-)HCCA) derived from Hahella chejuensis KCTC 2396 was over-expressed to enhance carbon flux toward bicarbonate ion (HCO3(-)) synthesis in E...
November 28, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27906934/can-unilateral-kyphoplasty-replace-bilateral-kyphoplasty-in-treatment-of-osteoporotic-vertebral-compression-fractures-a-systematic-review-and-meta-analysis
#14
Han Sun, Pei-Pei Lu, Yi-Jie Liu, Xu Yang, Ping-Hui Zhou, Xiao-Feng Shen, Si-Wei Sun, Huilin Yang
BACKGROUND: Kyphoplasty has been proven to be an efficient method to relieve patient suffering from osteoporotic vertebral compression fractures (OVCFs). Because of its technological superiority, unilateral kyphoplasty consumes less operative time and bone cement than traditional bilateral kyphoplasty. However, there is controversy about which method is most efficient in the treatment of OVCFs. Thus, an overall analysis should be performed to shed light on the facts corroborating both procedures...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27906401/efficient-organic-photovoltaic-cells-on-a-single-layer-graphene-transparent-conductive-electrode-using-moox-as-an-interfacial-layer
#15
J H Du, H Jin, Z K Zhang, D D Zhang, S Jia, L P Ma, W C Ren, H M Cheng, P L Burn
The large surface roughness, low work function and high cost of transparent electrodes using multilayer graphene films can limit their application in organic photovoltaic (OPV) cells. Here, we develop single layer graphene (SLG) films as transparent anodes for OPV cells that contain light-absorbing layers comprised of the evaporable molecular organic semiconductor materials, zinc phthalocyanine (ZnPc)/fullerene (C60), as well as a molybdenum oxide (MoOx) interfacial layer. In addition to an increase in the optical transmittance, the SLG anodes had a significant decrease in surface roughness compared to two and four layer graphene (TLG and FLG) anodes fabricated by multiple transfer and stacking of SLGs...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27905279/cloning-of-the-dna-vaccine-candidate-lack-gene-of-leishmania-infantum
#16
Serkan Karaca, Şirin Sahra Ceylan, Süleyman Yazar, Salih Kuk
OBJECTIVE: Leishmaniasis is caused by an obligate intracellular protozoa belonging to Leishmania genus and listed among major tropical diseases by WHO. Because of the high costs, toxicity, and adverse effects of routinely used compounds in the treatment, alternative treatment and vaccine studies are underway. An effective vaccine has not been developed to date. In this study, we aimed to clone one of the most promising DNA vaccine candidates: the homolog-activated C kinase (LACK) gene of Leishmania infantum...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27903559/randomised-controlled-trial-of-alternative-messages-to-increase-enrolment-in-a-healthy-food-programme-among-individuals-with-diabetes
#17
A Gopalan, J Paramanund, P A Shaw, D Patel, J Friedman, C Brophy, A M Buttenheim, A B Troxel, D A Asch, K G Volpp
OBJECTIVES: We compared the effectiveness of diabetes-focused messaging strategies at increasing enrolment in a healthy food programme among adults with diabetes. METHODS: Vitality is a multifaceted wellness benefit available to members of Discovery Health, a South Africa-based health insurer. One of the largest Vitality programmes is HealthyFood (HF), an incentive-based programme designed to encourage healthier diets by providing up to 25% cashback on healthy food purchases...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27901062/assessing-the-feasibility-of-fly-based-surveillance-of-wildlife-infectious-diseases
#18
Constanze Hoffmann, Melanie Stockhausen, Kevin Merkel, Sébastien Calvignac-Spencer, Fabian H Leendertz
Monitoring wildlife infectious agents requires acquiring samples suitable for analyses, which is often logistically demanding. A possible alternative to invasive or non-invasive sampling of wild-living vertebrates is the use of vertebrate material contained in invertebrates feeding on them, their feces, or their remains. Carrion flies have been shown to contain vertebrate DNA; here we investigate whether they might also be suitable for wildlife pathogen detection. We collected 498 flies in Taï National Park, Côte d'Ivoire, a tropical rainforest and examined them for adenoviruses (family Adenoviridae), whose DNA is frequently shed in feces of local mammals...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900684/dna-rna-and-protein-based-stable-isotope-probing-for-high-throughput-biomarker-analysis-of-active-microorganisms
#19
Eleanor Jameson, Martin Taubert, Sara Coyotzi, Yin Chen, Özge Eyice, Hendrik Schäfer, J Colin Murrell, Josh D Neufeld, Marc G Dumont
Stable-isotope probing (SIP) enables researchers to target active populations within complex microbial communities, which is achieved by providing growth substrates enriched in heavy isotopes, usually in the form of (13)C, (18)O, or (15)N. After growth on the substrate and subsequent extraction of microbial biomarkers, typically nucleic acids or proteins, the SIP technique is used for the recovery and analysis of isotope-labeled biomarkers from active microbial populations. In the years following the initial development of DNA- and RNA-based SIP, it was common practice to characterize labeled populations by targeted gene analysis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27900678/a-customized-quantitative-pcr-microrna-panel-provides-a-technically-robust-context-for-studying-neurodegenerative-disease-biomarkers-and-indicates-a-high-correlation-between-cerebrospinal-fluid-and-choroid-plexus-microrna-expression
#20
Wang-Xia Wang, David W Fardo, Gregory A Jicha, Peter T Nelson
MicroRNA (miRNA) expression varies in association with different tissue types and in diseases. Having been found in body fluids including blood and cerebrospinal fluid (CSF), miRNAs constitute potential biomarkers. CSF miRNAs have been proposed as biomarkers for neurodegenerative diseases; however, there is a lack of consensus about the best candidate miRNA biomarkers and there has been variability in results from different research centers, perhaps due to technical factors. Here, we sought to optimize technical parameters for CSF miRNA studies...
November 29, 2016: Molecular Neurobiology
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