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https://www.readbyqxmd.com/read/28227708/towards-detection-of-sleep-apnea-events-by-combining-different-non-contact-measurement-modalities
#1
Abdul Q Javaid, Carlo M Noble, Russell Rosenberg, Mary A Weitnauer, Abdul Q Javaid, Carlo M Noble, Russell Rosenberg, Mary A Weitnauer, Carlo M Noble, Abdul Q Javaid, Mary A Weitnauer, Russell Rosenberg
In this work, we extract features from an under-the-mattress impulse radio ultra-wide band (IR-UWB) radar and a microphone, placed on the side table of the bed, to classify epochs belonging to normal sleep and those that contain an apnea event in them. Sleep apnea is the most common form of sleep related breathing disorder in adults with an estimated prevalance of 5-15%. The common diagnostic process for sleep apnea, polysomnography (PSG), involves sleeping in well-equipped sleep clinics. The cost and discomfort associated with the process has spurred research towards the design of portable home-based monitoring devices...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227661/parameter-optimization-of-pseudo-rigid-body-models-of-mri-actuated-catheters
#2
Tipakorn Greigarn, Taoming Liu, M Cenk Cavusoglu, Tipakorn Greigarn, Taoming Liu, M Cenk Cavusoglu, Taoming Liu, Tipakorn Greigarn, M Cenk Cavusoglu
Simulation and control of a system containing compliant mechanisms such as cardiac catheters often incur high computational costs. One way to reduce the costs is to approximate the mechanisms with Pseudo-Rigid-Body Models (PRBMs). A PRBM generally consists of rigid links connected by spring-loaded revolute joints. The lengths of the rigid links and the stiffnesses of the springs are usually chosen to minimize the tip deflection differences between the PRBM and the compliant mechanism. In most applications, only the relationship between end load and tip deflection is considered...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227614/portable-prescreening-system-for-sleep-apnea
#3
Martin Kjaer Guul, Poul Jennum, Helge B D Sorensen, Martin Kjaer Guul, Poul Jennum, Helge B D Sorensen, Martin Kjaer Guul, Helge B D Sorensen, Poul Jennum
Obstructive sleep apnea (OSA) occurs in more than 4 % of the adult population. Diagnoses for OSA in sleep clinics are costly and more than half of those submitted to a sleep clinic do not have OSA. A simple, easy, and portable homebased monitoring system to evaluate who are in high-or low risk of suffering from OSA would be beneficial. The system must be able to identify individuals with a high pre-test reliability regarding OSA with the aim of referral and further investigation. We aimed to develop a portable, smartphone, and homebased monitoring system to classify whether a patient screened for sleep apnea is at high risk or low risk of having OSA...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227433/microprinted-tumor-spheroids-enable-anti-cancer-drug-screening
#4
Pradip S Thakuri, Stephanie L Ham, Hossein Tavana, Pradip S Thakuri, Stephanie L Ham, Hossein Tavana, Stephanie L Ham, Hossein Tavana
Spheroids present a biologically relevant model of avascular tumors and a unique tool for discovery of anti-cancer drugs. Despite being used in research laboratories for several decades, spheroids are not routinely used for drug discovery primarily due to the difficulty of mass-producing uniformly-sized spheroids and intense labor involved in handling, drug treatment, and analyzing them. We overcome this barrier using a novel technology to robotically microprint spheroids in standard 384-well plates. An aqueous drop containing cancer cells is dispensed into a bath of a second, immiscible aqueous phase...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226937/design-of-a-bio-inspired-pneumatic-artificial-muscle-with-self-contained-sensing
#5
Onder Erin, Nishant Pol, Luis Valle, Yong-Lae Park, Onder Erin, Nishant Pol, Luis Valle, Yong-Lae Park, Nishant Pol, Luis Valle, Onder Erin, Yong-Lae Park
Pneumatic artificial muscles (PAMs) are one of the most famous linear actuators in bio-inspired robotics. They can generate relatively high linear force considering their form factors and weights. Furthermore, PAMs are inexpensive compared with traditional electromagnetic actuators (e.g. DC motors) and also inherently light and compliant. In robotics applications, however, they typically require external sensing mechanisms due to their nonlinear behaviors, which may make the entire mechanical system bulky and complicated, limiting their use in simple systems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226499/origami-microfluidic-paper-analytical-devices-ompad-for-sensing-and-diagnostics
#6
Meera Punjiya, Chung Hee Moon, Yu Chen, Sameer Sonkusale, Meera Punjiya, Chung Hee Moon, Yu Chen, Sameer Sonkusale, Yu Chen, Chung Hee Moon, Sameer Sonkusale, Meera Punjiya
Recent research activities in the area of low-cost sensing and diagnostics that are realized on cellulosic paper substrate are presented. First a three-dimensional origami paper-based analytical device (omPAD) with multiple electrochemical sensors, an integrated sample reservoir and tight integration with a custom CMOS potentiostat is presented. Second, an optical sensor array with built-in microfluidic channel for sample delivery is presented. The sensors are fabricated using a combination of wax printing and screen-printing using a solution based approach in ambient conditions without the need for expensive fabrication equipment or a cleanroom...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225198/adjunctive-steroid-therapy-versus-antibiotics-alone-for-acute-endophthalmitis-after-intraocular-procedure
#7
REVIEW
Carole H Kim, Monica F Chen, Anne L Coleman
BACKGROUND: Endophthalmitis refers to severe infection within the eye that involves the aqueous humor or vitreous humor, or both, and threatens vision. Most cases of endophthalmitis are exogenous (i.e. due to inoculation of organisms from an outside source), and most exogenous endophthalmitis is acute and occurs after an intraocular procedure. The mainstay of treatment is emergent administration of broad-spectrum intravitreous antibiotics. Due to their anti-inflammatory effects, steroids in conjunction with antibiotics have been proposed to be beneficial in endophthalmitis management...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28224884/water-soluble-co-polyelectrolytes-by-selective-modification-of-cellulose-esters
#8
Shu Liu, Kevin J Edgar
Cellulose-based materials are well-suited for biomedical uses, because of their abundance, renewable nature, biodegradability, and relatively low cost. However, the set of commercially available cellulose esters and ethers is limited in number and diversity, and contains no cationically charged cellulose esters. Herein we report a simple, efficient strategy for synthesizing cationic, water-soluble co-polyelectrolytes from commercial, hydrophobic, renewable-based cellulose esters. Cellulose acetate (degree of substitution (DS) 1...
April 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28222685/evaluation-of-the-accuracy-of-imputed-sequence-variant-genotypes-and-their-utility-for-causal-variant-detection-in-cattle
#9
Hubert Pausch, Iona M MacLeod, Ruedi Fries, Reiner Emmerling, Phil J Bowman, Hans D Daetwyler, Michael E Goddard
BACKGROUND: The availability of dense genotypes and whole-genome sequence variants from various sources offers the opportunity to compile large datasets consisting of tens of thousands of individuals with genotypes at millions of polymorphic sites that may enhance the power of genomic analyses. The imputation of missing genotypes ensures that all individuals have genotypes for a shared set of variants. RESULTS: We evaluated the accuracy of imputation from dense genotypes to whole-genome sequence variants in 249 Fleckvieh and 450 Holstein cattle using Minimac and FImpute...
February 21, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28221883/enrichment-amplification-and-sequence-based-typing-of-salmonella-enterica-and-other-foodborne-pathogens
#10
Tom Edlind, Jeffrey D Brewster, George C Paoli
Detection of Salmonella enterica in foods typically involves microbiological enrichment, molecular-based assay, and subsequent isolation and identification of a pure culture. This is ideally followed by strain typing, which provides information critical to the investigation of outbreaks and the attribution of their sources. Pulsed-field gel electrophoresis is the "gold standard" for S. enterica strain typing, but its limitations have encouraged the search for alternative methods, including whole genome sequencing...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221781/the-relationship-between-organic-loading-and-effects-on-fish-reproduction-for-pulp-mill-effluents-across-canada
#11
Pierre H Martel, Brian I O'Connor, Tibor G Kovacs, Michael R Van Den Heuvel, Joanne L Parrott, Mark E McMaster, Deborah L MacLatchy, Glen J Van Der Kraak, L Mark Hewitt
This study builds upon the work of a multiagency consortium tasked with determining cost effective solutions for the effects of pulp mill effluents on fish reproduction. A laboratory fathead minnow egg production test and chemical characterization tools were used to benchmark eighty-one effluents from twenty mills across Canada, representing the major pulping, bleaching and effluent treatment technologies. For Kraft and mechanical pulp mills, effluents containing less than 20 mg/L BOD5 were found to have the greatest probability of having no effects...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28221760/hydrogel-nanocomposites-with-independently-tunable-rheology-and-mechanics
#12
Shimon Unterman, Lyndon F Charles, Sara E Strecker, Denis Kramarenko, Dmitry Pivovarchik, Elazer Reuven Edelman, Natalie Artzi
Hydrogels are an attractive class of biomaterials for minimally invasive local drug delivery given their injectability, tunability, high water content, and biocompatibility. Broad applicability though is challenged: relatively modest mechanical properties restricts use to soft tissues, while flow properties necessary for injectability limit implantation to dried, enclosed tissues to minimize material migration during gelation. To address these dual concerns we designed an injectable nanocomposite hydrogel based on dextran aldehyde and poly(amido amine) dendrimer doped with phyllosilicate nanoplatelet fillers...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28221723/animal-component-free-agrobacterium-tumefaciens-cultivation-media-for-better-gmp-compliance-increases-biomass-yield-and-pharmaceutical-protein-expression-in-nicotiana-benthamiana
#13
Marcel Houdelet, Anna Galinski, Tanja Holland, Kathrin Wenzel, Stefan Schillberg, Johannes Felix Buyel
Transient expression systems allow the rapid production of recombinant proteins in plants. Such systems can be scaled up to several hundred kilograms of biomass, making them suitable for the production of pharmaceutical proteins required at short notice, such as emergency vaccines. However, large-scale transient expression requires the production of recombinant Agrobacterium tumefaciens strains with the capacity for efficient gene transfer to plant cells. The complex media often used for the cultivation of this species typically include animal-derived ingredients that can contain human pathogens, thus conflicting with the requirements of good manufacturing practice (GMP)...
February 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28221699/beehive-fences-as-a-multidimensional-conflict-mitigation-tool-for-farmers-coexisting-with-elephants
#14
Lucy E King, Fredrick Lala, Hesron Nzumu, Emmanuel Mwambingu, Iain Douglas-Hamilton
Increasing habitat fragmentation and human population growth in Africa has resulted in an escalation in human-elephant conflict between small-scale farmers and free-ranging African elephants (Loxodonta Africana). In 2012 Kenya Wildlife Service (KWS) implemented the national 10-year Conservation and Management Strategy for the Elephant in Kenya, which includes an action aimed at testing whether beehive fences can be used to mitigate human-elephant conflict. From 2012 to 2015, we field-tested the efficacy of beehive fences to protect 10 0...
February 21, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28220488/optimization-of-foraging-and-diet-by-the-piscivorous-othos-dentex-serranidae
#15
B French, M E Platell, K R Clarke, I C Potter
The aim of this study was to determine the dietary characteristics and mouth morphology of Othos dentex and to use these data, together with in situ observations of feeding behaviour, to elucidate how foraging and diet are optimized by this piscivorous serranid. Seasonal spear and line fishing over reefs in south-western Australia yielded 426 O. dentex (total length, LT , 183-605 mm), among which the stomachs of 95 contained food. The food in the stomachs of 76 fish was sufficiently undigested to be seen to contain, almost invariably, a single fish prey, which was typically identifiable to family and often to species...
February 20, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28220440/quantum-probability-ranking-principle-for-ligand-based-virtual-screening
#16
Mohammed Mumtaz Al-Dabbagh, Naomie Salim, Mubarak Himmat, Ali Ahmed, Faisal Saeed
Chemical libraries contain thousands of compounds that need screening, which increases the need for computational methods that can rank or prioritize compounds. The tools of virtual screening are widely exploited to enhance the cost effectiveness of lead drug discovery programs by ranking chemical compounds databases in decreasing probability of biological activity based upon probability ranking principle (PRP). In this paper, we developed a novel ranking approach for molecular compounds inspired by quantum mechanics, called quantum probability ranking principle (QPRP)...
February 20, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28220139/genome-wide-single-nucleotide-polymorphism-discovery-and-the-construction-of-a-high-density-genetic-map-for-melon-cucumis-melo-l-using-genotyping-by-sequencing
#17
Che-Wei Chang, Yu-Hua Wang, Chih-Wei Tung
Although genotyping-by-sequencing (GBS) enables the efficient and low-cost generation of large numbers of markers, the utility of resultant genotypes are limited, because they are enormously error-prone and contain high proportions of missing data. In this study, we generated single nucleotide polymorphism (SNP) markers for 109 recombinant inbred lines of melon (Cucumis melo L.) using the GBS approach and ordered them according to their physical position on the draft double haploid line DHL92 genome. Next, by investigating associations between these SNPs, we discovered that some segments on the physical map conflict with linkage relationships...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28219992/a-new-handheld-device-for-the-detection-of-falsified-medicines-demonstration-on-falsified-artemisinin-based-therapies-from-the-field
#18
Benjamin K Wilson, Harparkash Kaur, Elizabeth Louise Allan, Anthony Lozama, David Bell
Poor-quality medicines are a major problem for health-care systems in resource-poor settings as identifying falsified medicines requires a complex laboratory infrastructure such as a Medicines Quality Control Laboratory. We report here an evaluation of a low-cost, handheld near-infrared spectrometer (NIRS) device by analyzing a library of artemisinin-based combination therapy (ACT) medicines to determine its usefulness as a drug-screening tool. The "SCiO" research prototype device was used to collect NIR spectra of a library of ACT and artesunate monotherapy medicine samples previously collected in Bioko Island and Equatorial Guinea and Kintampo, Ghana...
February 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28218646/impact-of-consuming-toxic-monarch-caterpillars-on-adult-chinese-mantid-mass-gain-and-fecundity
#19
Jamie L Rafter, Liahna Gonda-King, Daniel Niesen, Navindra P Seeram, Chad M Rigsby, Evan L Preisser
Predators that feed on chemically-defended prey often experience non-lethal effects that result in learned avoidance of the prey species. Some predators are able to consume toxic prey without ill-effect. The Chinese mantid is able to consume cardenolide-containing monarch caterpillars without immediate adverse effects. Although they discard the caterpillars' gut contents, mantids consume sequestered cardenolides. Although consumption of these cardenolides does not elicit an acute response, there may be long-term costs associated with cardenolide consumption...
February 17, 2017: Insects
https://www.readbyqxmd.com/read/28218404/topical-medication-instillation-techniques-for-glaucoma
#20
REVIEW
Li Xu, Xuemei Wang, Meijing Wu
BACKGROUND: Glaucoma is a leading cause of irreversible blindness worldwide and the second most common cause of blindness after cataracts. The primary treatment for glaucoma aims to lower intraocular pressure (IOP) with the use of topical medicines. Topical medication instillation techniques, such as eyelid closure and nasolacrimal occlusion when instilling drops, have been proposed as potential methods to increase ocular absorption and decrease systemic absorption of the drops. OBJECTIVES: To investigate the effectiveness of topical medication instillation techniques compared with usual care or another method of instillation of topical medication in the management of glaucoma or ocular hypertension...
February 20, 2017: Cochrane Database of Systematic Reviews
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