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JOURNAL ARTICLE
Jamie O Musick, Evelyn K Williams, Kirby S Fibben, Dan Y Zhang, Christina Caruso, Yumiko Sakurai, Reginald Tran, Melissa L Kemp, Wilbur A Lam
Hyperleukocytosis is an emergency of acute leukemia leading to blood hyperviscosity, potentially resulting in life-threatening microvascular obstruction, or leukostasis. Due to the high number of red cells in the circulation, hematocrit/hemoglobin levels (Hct/Hgb) are major drivers of blood viscosity, but how Hct/Hgb mediates hyperviscosity in acute leukemia remains unknown. In vivo hemorheological studies are difficult to conduct and interpret due to issues related to visualizing and manipulating the microvasculature...
April 4, 2024: American Journal of Hematology
#2
JOURNAL ARTICLE
Melanie Korndorffer, Michael A Dewsnap, Erin S Barry, Neil Grunberg, David W Musick, Joann Farrell Quinn
INTRODUCTION: The physician's role in the healthcare delivery system extends beyond patient care to include numerous critical leadership roles in healthcare. In addition to treating patients, physicians manage multidisciplinary teams and influence policies to optimise public health. Yet, leadership education is not currently emphasised as part of undergraduate medical education. The purpose of this pilot study was to survey US allopathic medical schools about their current leadership curricula for medical students, including aspects that promote or inhibit effective curricular implementation...
April 2, 2024: BMJ leader
#3
JOURNAL ARTICLE
Adam N Musick, Do Young Kim, Steven J Baumrucker
BACKGROUND: Lichen planus is a T-cell mediated inflammatory disorder of the skin and mucus membranes and is a rare complication of external beam radiation. CASE PRESENTATION: 64 year old White male who presented to dermatology with a lesion at the lateral aspect of the right thigh. The lesion was first noted 40 years prior and had grown from 1.5 cm to 6.5 cm in the ensuing years. On examination the lesion was raised, hypopigmented, with pearly borders and central ulceration...
March 31, 2024: Journal of Medical Case Reports
#4
JOURNAL ARTICLE
Dorean Nabukalu, Constantin T Yiannoutsos, Aggrey Semeere, Beverly S Musick, Teddy Murungi, Jane Viola Namulindwa, Francis Waswa, Gertrude Nakigozi, Nelson K Sewankambo, Steven J Reynolds, Tom Lutalo, Fredrick Makumbi, Godfrey Kigozi, Fred Nalugoda, Kara Wools-Kaloustian
BACKGROUND: Monitoring and evaluation of clinical programs requires assessing patient outcomes. Numerous challenges complicate these efforts, the most insidious of which is loss to follow-up (LTFU). LTFU is a composite outcome, including individuals out of care, undocumented transfers, and unreported deaths. Incorporation of vital status information from routine patient outreach may improve the mortality estimates for those LTFU. SETTINGS: We analyzed routinely collected clinical and patient tracing data for individuals (15 years or older) initiating antiretroviral treatment between January 2014 and December 2018 at 2 public HIV care clinics in greater Rakai, Uganda...
March 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#5
JOURNAL ARTICLE
Eric Venner, Karynne Patterson, Divya Kalra, Marsha M Wheeler, Yi-Ju Chen, Sara E Kalla, Bo Yuan, Jason H Karnes, Kimberly Walker, Joshua D Smith, Sean McGee, Aparna Radhakrishnan, Andrew Haddad, Philip E Empey, Qiaoyan Wang, Lee Lichtenstein, Diana Toledo, Gail Jarvik, Anjene Musick, Richard A Gibbs
Disparities in data underlying clinical genomic interpretation is an acknowledged problem, but there is a paucity of data demonstrating it. The All of Us Research Program is collecting data including whole-genome sequences, health records, and surveys for at least a million participants with diverse ancestry and access to healthcare, representing one of the largest biomedical research repositories of its kind. Here, we examine pathogenic and likely pathogenic variants that were identified in the All of Us cohort...
February 19, 2024: Communications Biology
#6
JOURNAL ARTICLE
Niall J Lennon, Leah C Kottyan, Christopher Kachulis, Noura S Abul-Husn, Josh Arias, Gillian Belbin, Jennifer E Below, Sonja I Berndt, Wendy K Chung, James J Cimino, Ellen Wright Clayton, John J Connolly, David R Crosslin, Ozan Dikilitas, Digna R Velez Edwards, QiPing Feng, Marissa Fisher, Robert R Freimuth, Tian Ge, Joseph T Glessner, Adam S Gordon, Candace Patterson, Hakon Hakonarson, Maegan Harden, Margaret Harr, Joel N Hirschhorn, Clive Hoggart, Li Hsu, Marguerite R Irvin, Gail P Jarvik, Elizabeth W Karlson, Atlas Khan, Amit Khera, Krzysztof Kiryluk, Iftikhar Kullo, Katie Larkin, Nita Limdi, Jodell E Linder, Ruth J F Loos, Yuan Luo, Edyta Malolepsza, Teri A Manolio, Lisa J Martin, Li McCarthy, Elizabeth M McNally, James B Meigs, Tesfaye B Mersha, Jonathan D Mosley, Anjene Musick, Bahram Namjou, Nihal Pai, Lorenzo L Pesce, Ulrike Peters, Josh F Peterson, Cynthia A Prows, Megan J Puckelwartz, Heidi L Rehm, Dan M Roden, Elisabeth A Rosenthal, Robb Rowley, Konrad Teodor Sawicki, Daniel J Schaid, Roelof A J Smit, Johanna L Smith, Jordan W Smoller, Minta Thomas, Hemant Tiwari, Diana M Toledo, Nataraja Sarma Vaitinadin, David Veenstra, Theresa L Walunas, Zhe Wang, Wei-Qi Wei, Chunhua Weng, Georgia L Wiesner, Xianyong Yin, Eimear E Kenny
Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can be implemented in the clinic, including reduced predictive performance of PRSs in diverse populations, and the interpretation and communication of genetic results to both providers and patients. To address these challenges, the National Human Genome Research Institute-funded Electronic Medical Records and Genomics (eMERGE) Network has developed a framework and pipeline for return of a PRS-based genome-informed risk assessment to 25,000 diverse adults and children as part of a clinical study...
February 2024: Nature Medicine
#7
JOURNAL ARTICLE
Chemtai Mungo, Omenge Orang'o, Susan Ofner, Beverly Musick, Constantin Yiannoutsos, Craig R Cohen, Darron Brown, Kara Wools-Kaloustian, Aggrey Semeere
PURPOSE: To achieve the WHO cervical cancer elimination targets, countries globally must achieve 70% cervical cancer screening (CCS) coverage. We evaluated CCS uptake and predictors of screening positive at two public HIV care programs in western Kenya. METHODS: From October 2007 to February 2019, data from the Family AIDS Care and Education Services (FACES) and Academic Model Providing Access to Healthcare (AMPATH) programs in western Kenya were analyzed. The study population included women age 18-65 years enrolled in HIV care...
February 2024: JCO global oncology
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JOURNAL ARTICLE
Mariah Rudd, Shari Whicker, R Brock Mutcheson, Alisa Nagler, David Musick
BACKGROUND: Little is known about medical school requirements for faculty development related to teaching (FDT) in medical education. This study examined the national landscape and local faculty perceptions of their own institution's FDT requirement. METHODS: An electronic survey was disseminated to Faculty Affairs Offices in US medical schools to assess FDT requirements. A second survey was distributed to faculty within one medical school to gauge faculty perceptions related to existing FDT requirements...
January 24, 2024: Journal of Continuing Education in the Health Professions
#9
JOURNAL ARTICLE
Claire M Ghetti, Steinar Hjelmbrekke, Katharina Morken, Therese Dahl, Brynjulf Stige
BACKGROUND: User perspectives and involvement are crucial for improving substance use treatment service provision. First-hand accounts provide rich perspectives on how users experience change within therapeutic approaches like music therapy. People with substance use problems have a higher incidence of experiencing challenges with impulsivity, hyperactivity and inattention. Such challenges can negatively affect social functioning and outcomes of substance use treatment. Music therapy can offer people a means to regulate emotions and facilitate social relationships...
January 23, 2024: Substance Abuse Treatment, Prevention, and Policy
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JOURNAL ARTICLE
Maša Davidović, Serra Lem Asangbeh, Katayoun Taghavi, Tafadzwa Dhokotera, Antoine Jaquet, Beverly Musick, Cari Van Schalkwyk, David Schwappach, Eliane Rohner, Gad Murenzi, Kara Wools-Kaloustian, Kathryn Anastos, Orang'o Elkanah Omenge, Simon Pierre Boni, Stephany N Duda, Per von Groote, Julia Bohlius
BACKGROUND: Of women with cervical cancer (CC) and HIV, 85% live in sub-Saharan Africa, where 21% of all CC cases are attributable to HIV infection. We aimed to generate internationally acceptable facility-based indicators to monitor and guide scale up of CC prevention and care services offered on-site or off-site by HIV clinics. METHODS: We reviewed the literature and extracted relevant indicators, grouping them into domains along the CC control continuum. From February 2021 to March 2022, we conducted a three-round, online Delphi process to reach consensus on indicators...
February 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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REVIEW
Dalia A Bashir, Jamie C Cargill, Srinath Gowda, Matthew Musick, Ryan Coleman, Corey A Chartan, Lisa Hensch, Amir Pezeshkmehr, Athar M Qureshi, Sarah E Sartain
Pulmonary embolism is increasing in prevalence among pediatric patients; although still rare, it can create a significant risk for morbidity and death within the pediatric patient population. Pulmonary embolism presents in various ways depending on the patient, the size of the embolism, and the comorbidities. Treatment decisions are often driven by the severity of the presentation and hemodynamic effects; severe presentations require more invasive and aggressive treatment. We describe the development and implementation of a pediatric pulmonary embolism response team designed to facilitate rapid, multidisciplinary, data-driven treatment decisions and management...
January 2024: Chest
#12
MULTICENTER STUDY
Pau Abrisqueta, Eva González-Barca, Carlos Panizo, José María Arguiñano Pérez, Fiona Miall, Mariana Bastos-Oreiro, Ana Triguero, Lalita Banerjee, Andrew McMillan, Erlene Seymour, Jamie Hirata, Jayson de Guzman, Sunil Sharma, Hyun Yong Jin, Lisa Musick, Catherine Diefenbach
BACKGROUND: Diffuse large B-cell lymphoma comprises nearly 30% of non-Hodgkin lymphoma cases and patients with relapsed or refractory diffuse large B-cell lymphoma who are ineligible for stem-cell transplantation have few treatment options and poor prognoses. We aimed to determine whether the novel combination of polatuzumab vedotin in combination with rituximab and lenalidomide (Pola+R+Len) would provide a tolerable treatment option with enhanced antitumour response in patients with relapsed or refractory diffuse large B-cell lymphoma...
February 2024: Lancet Haematology
#13
JOURNAL ARTICLE
Theresa A Allison, Jennie M Gubner, Krista L Harrison, Alexander K Smith, Deborah E Barnes, Kenneth E Covinsky, Kristine Yaffe, Julene K Johnson
BACKGROUND AND OBJECTIVES: Emerging evidence suggests music-based interventions can improve well-being for people living with dementia, but little is known about the ways in which music might support dementia caregiving relationships as part of everyday life at home. This study examined music engagement in the context of daily life to identify patterns of music engagement and potential targets for the design of music-based interventions to support well-being. RESEARCH DESIGN AND METHODS: This ethnographic, in-home study of people living with dementia and their family and professional care partners used methods from ethnomusicology, including semi-structured interviews and in-home participant-observation with a focus on music engagement...
December 30, 2023: Gerontologist
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JOURNAL ARTICLE
Michael Sokoloff, Kenneth W Feldman, Alex V Levin, Adam Rockter, Veronica Armijo-Garcia, Matthew Musick, Kerri Weeks, Suzanne B Haney, Mark Marinello, Bruce E Herman, Terra N Frazier, Christopher L Carroll, Kent P Hymel
BACKGROUND: Abusive head trauma (AHT) is frequently accompanied by dense/extensive retinal hemorrhages to the periphery with or without retinoschisis (complex retinal hemorrhages, cRH). cRH are uncommon without AHT or major trauma. OBJECTIVE: The study objectives were to determine whether cRH are associated with inertial vs. contact mechanisms and are primary vs. secondary injuries. PARTICIPANTS AND SETTING: This retrospective study utilized a de-identified PediBIRN database of 701 children <3-years-old presenting to intensive care for head trauma...
December 21, 2023: Child Abuse & Neglect
#15
JOURNAL ARTICLE
Jenna Wood Bartlett, Brooke N Curry, Matthew A Musick, Megan McKee Moore
OBJECTIVE: Given the limited literature describing propofol use in pediatric patients, this study aimed to describe the dosing and duration of propofol infusions for non-procedural sedation in the pediatric intensive care unit (PICU). The secondary objectives were to describe the change in concomitant sedative requirements from the 24-hour period before propofol initiation to the 24-hour period after discontinuation of propofol and to review the frequency of adverse events. METHODS: This retrospective descriptive cohort study evaluated children 1 month to less than 18 years old who received a continuous infusion of propofol for non-procedural sedation in the PICU between May 2018 and August 2020...
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
#16
JOURNAL ARTICLE
Kassem Bourgi, Susan Ofner, Beverly Musick, Kara Wools-Kaloustian, John M Humphrey, Lameck Diero, Constantin T Yiannoutsos, Samir K Gupta
BACKGROUND: Switching from non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens to dolutegravir (DTG) has been associated with greater weight gain. METHODS: We conducted our analysis using a longitudinal cohort of people with HIV (PWH) in Western Kenya. We evaluated changes in the rate of weight gain among treatment-experienced, virally suppressed PWH who switched from NNRTI to tenofovir disoproxil fumarate, lamivudine, and dolutegravir (TLD). We modeled the weights pre- and postswitch using a 2-phase model with linear trend preswitch and an inverted exponential function postswitch...
December 2023: Open Forum Infectious Diseases
#17
JOURNAL ARTICLE
Sarah C Lotspeich, Bryan E Shepherd, Marion Achieng Kariuki, Kara Wools-Kaloustian, Catherine C McGowan, Beverly Musick, Aggrey Semeere, Brenda E Crabtree Ramírez, Denna M Mkwashapi, Carina Cesar, Matthew Ssemakadde, Daisy Maria Machado, Antony Ngeresa, Flávia Faleiro Ferreira, Jerome Lwali, Adias Marcelin, Sandra Wagner Cardoso, Marco Tulio Luque, Larissa Otero, Claudia P Cortés, Stephany N Duda
INTRODUCTION: Routine patient care data are increasingly used for biomedical research, but such "secondary use" data have known limitations, including their quality. When leveraging routine care data for observational research, developing audit protocols that can maximize informational return and minimize costs is paramount. METHODS: For more than a decade, the Latin America and East Africa regions of the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium have been auditing the observational data drawn from participating human immunodeficiency virus clinics...
2023: Journal of Clinical and Translational Science
#18
JOURNAL ARTICLE
William A Millar, Landon R Armstrong, Robert M Becker, Adam N Musick, David B Ryan, Thomas E Kwasigroch
INTRODUCTION: Soft-embalmed cadavers have been used in medical education with a variety of success in different curriculum objectives. In the United States, the ACL is the most commonly injured ligament. Yet, there has been little focus on the stability of the knee in the sagittal plane provided by the anterior cruciate ligament within the soft-embalmed cadaver model. If the soft-embalmed cadaver ligaments contain similar elastic properties as an in-vivo knees, this will offer yet another means for further advancements in medical education to detect and assess musculoskeletal injuries...
2023: Advances in Medical Education and Practice
#19
JOURNAL ARTICLE
Robin I M Dunbar
Music is widely recognised as a human universal, yet there is no agreed explanation for its function, or why and when it evolved. I summarise experimental evidence that the primary function of musicking lies in social bonding, both at the dyadic and community levels, via the effect that performing any form of music has on the brain's endorphin system (the principal neurohormonal basis for social bonding in primates). The many other functions associated with music-making (mate choice, pleasure, coalition signalling, etc) are all better understood as derivative of this, either as secondary selection pressures or as windows of evolutionary opportunity (exaptations)...
2023: Frontiers in Psychology
#20
JOURNAL ARTICLE
Emily Hatheway Marshall, Denisse Porras Fimbres, Alexis Musick, Robert French, Jonathan Martin, Poonam Sharma
No abstract text is available yet for this article.
November 1, 2022: Academic Medicine
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