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https://www.readbyqxmd.com/read/28604501/an-observational-study-of-the-effect-of-patient-outreach-on-return-to-care-the-earlier-the-better
#1
Peter F Rebeiro, Giorgos Bakoyannis, Beverly S Musick, Ronald S Braithwaite, Kara K Wools-Kaloustian, Winstone Nyandiko, Fatma Some, Paula Braitstein, Constantin T Yiannoutsos
BACKGROUND: The burden of HIV remains heaviest in resource-limited settings, where problems of losses to care, silent transfers, gaps in care, and incomplete mortality ascertainment have been recognized. METHODS: Patients in care at Academic Model Providing Access to Healthcare (AMPATH) clinics from 2001-2011 were included in this retrospective observational study. Patients missing an appointment were traced by trained staff; those found alive were counseled to return to care (RTC)...
June 9, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28520616/pediatric-cancer-burden-and-treatment-resources-within-the-pediatric-iedea-consortium
#2
Steven A Brown, Salma Abbas, Mary-Ann Davies, Torsak Bunupuradah, Annette H Sohn, Karl-Günter Technau, Lorna Renner, Valériane Leroy, Andrew Edmonds, Marcel Yotebieng, Catherine C McGowan, Stephany N Duda, Lynne Mofenson, Beverly Musick, Kara Wools-Kaloustian
INTRODUCTION: The incidence and treatment of cancer in HIV-infected children from resource-limited settings has not been extensively studied. OBJECTIVES: Develop and implement a cross-sectional survey to evaluate pediatric cancer burden, diagnostic modalities in use, and treatment availability as perceived by HIV clinic staff at regional International Epidemiology Databases to Evaluate AIDS (IeDEA) sites. METHODS: IeDEA regional investigators developed a cross-sectional clinical site survey which included questions on the numbers and types of pediatric cancers observed, modalities used to treat identified cancers and treatment options available at individual sites in the Asia-Pacific, Latin America, Central Africa, East Africa, West Africa, and Southern Africa regions...
May 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498147/reply
#3
Constantin T Yiannoutsos, Kara K Wools-Kaloustian, Beverly S Musick, Batya Elul
No abstract text is available yet for this article.
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28480289/community-environmental-contamination-of-toxigenic-clostridium-difficile
#4
M Jahangir Alam, Seth T Walk, Bradley T Endres, Eugenie Basseres, Mohammed Khaleduzzaman, Jonathan Amadio, William L Musick, Jennifer L Christensen, Julie Kuo, Robert L Atmar, Kevin W Garey
BACKGROUND: Clostridium difficile infection is often considered to result from recent acquisition of a C difficile isolate in a healthcare setting. However, C difficile spores can persist for long periods of time, suggesting a potentially large community environmental reservoir. The objectives of this study were to assess community environmental contamination of toxigenic C difficile and to assess strain distribution in environmental versus clinical isolates. METHODS: From 2013 to 2015, we collected community environmental swabs from homes and public areas in Houston, Texas to assess C difficile contamination...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28372489/music-for-all-including-young-people-with-intellectual-disability-in-a-university-environment
#5
Daphne Rickson, Penny Warren
We investigated a continuing education course in creative music making, initiated to promote the inclusion of young people with intellectual disability in a university setting. Despite organizers' attempts to foster diversity within the student cohort, enrolments were almost exclusively from students who had intellectual disability. Being in the university environment, and in a place of higher learning, seemed to be valued by some. However, students' main focus was on group musicking in a dedicated music room rather than interacting with the wider university community...
January 1, 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/28364561/comprehensiveness-of-hiv-care-provided-at-global-hiv-treatment-sites-in-the-iedea-consortium-2009-and-2014
#6
Cristin Q Fritz, Meridith Blevins, Mary Lou Lindegren, Kara Wools-Kaloutsian, Beverly S Musick, Morna Cornell, Kelly Goodwin, Dianne Addison, Jean Claude Dusingize, Eugène Messou, Armel Poda, Stephany N Duda, Catherine C McGowan, Matthew G Law, Richard D Moore, Aimee Freeman, Denis Nash, C William Wester
INTRODUCTION: An important determinant of the effectiveness of HIV treatment programs is the capacity of sites to implement recommended services and identify systematic changes needed to ensure that invested resources translate into improved patient outcomes. We conducted a survey in 2014 of HIV care and treatment sites in the seven regions of the International epidemiologic Database to Evaluate AIDS (IeDEA) Consortium to evaluate facility characteristics, HIV prevention, care and treatment services provided, laboratory capacity, and trends in the comprehensiveness of care compared to data obtained in the 2009 baseline survey...
January 6, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28328934/proviruses-with-identical-sequences-comprise-a-large-fraction-of-the-replication-competent-hiv-reservoir
#7
John K Bui, Michele D Sobolewski, Brandon F Keele, Jonathan Spindler, Andrew Musick, Ann Wiegand, Brian T Luke, Wei Shao, Stephen H Hughes, John M Coffin, Mary F Kearney, John W Mellors
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4+ T-cells and is stable despite years of suppressive antiretroviral therapy. A potential mechanism for HIV persistence is clonal expansion of infected cells, but how often such clones carry replication-competent proviruses has been controversial. Here, we used single-genome sequencing to probe for identical HIV sequence matches among viruses recovered in different viral outgrowth cultures and between the sequences of outgrowth viruses and proviral or intracellular HIV RNA sequences in uncultured blood mononuclear cells from eight donors on suppressive ART with diverse proviral populations...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28291055/rejoinder-to-lost-opportunities-concerning-loss-to-follow-up-a-response-to-elul-et-al-by-strassle-and-colleagues
#8
Constantin T Yiannoutsos, Kara K Wools-Kaloustian, Beverly S Musick, Batya Elul
No abstract text is available yet for this article.
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27851528/1893-venovenous-extracorporeal-membrane-oxygenation-for-refractory-status-asthmaticus-a-case-series
#9
Brian Rissmiller, Brian Young, Matthew Musick, Lara Shekerdemian, Maria Gazzaneo
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849840/197-the-evaluation-of-vasoactive-inotrope-score-in-the-pediatric-intensive-care-unit
#10
Matthew Musick, Curtis Kennedy, Laura Loftis
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849753/109-outcomes-of-unplanned-admissions-to-a-pediatric-intensive-care-unit
#11
Aarti Bavare, Karla Abela, Kimia Rafie, Pamela Marshall, Matthew Musick
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27535610/associations-between-daily-musicking-and-health-results-from-a-nationwide-survey-in-denmark
#12
Ola Ekholm, Knud Juel, Lars Ole Bonde
AIMS: To examine the associations between singing/playing musical instruments daily and various outcomes such as health-related quality of life and health behaviour. METHODS: Data originates from the Danish Health and Morbidity Survey 2013. The survey was based on a random sample of 25,000 adult Danes (response rate: 57%). Besides standard health-related questions the survey included eight specific music questions, based on a review of the sparse literature on music and health...
August 16, 2016: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/27509182/facility-level-factors-influencing-retention-of-patients-in-hiv-care-in-east-africa
#13
Beth Rachlis, Giorgos Bakoyannis, Philippa Easterbrook, Becky Genberg, Ronald Scott Braithwaite, Craig R Cohen, Elizabeth A Bukusi, Andrew Kambugu, Mwebesa Bosco Bwana, Geoffrey R Somi, Elvin H Geng, Beverly Musick, Constantin T Yiannoutsos, Kara Wools-Kaloustian, Paula Braitstein
Losses to follow-up (LTFU) remain an important programmatic challenge. While numerous patient-level factors have been associated with LTFU, less is known about facility-level factors. Data from the East African International epidemiologic Databases to Evaluate AIDS (EA-IeDEA) Consortium was used to identify facility-level factors associated with LTFU in Kenya, Tanzania and Uganda. Patients were defined as LTFU if they had no visit within 12 months of the study endpoint for pre-ART patients or 6 months for patients on ART...
2016: PloS One
https://www.readbyqxmd.com/read/27150964/mothering-experiences-how-single-parenthood-and-employment-structure-the-emotional-valence-of-parenting
#14
Ann Meier, Kelly Musick, Sarah Flood, Rachel Dunifon
Research studies and popular accounts of parenting have documented the joys and strains of raising children. Much of the literature comparing parents with those without children indicates a happiness advantage for those without children, although recent studies have unpacked this general advantage to reveal differences by the dimension of well-being considered and important features in parents' lives and parenting experiences. We use unique data from the 2010, 2012, and 2013 American Time Use Survey to understand emotions in mothering experiences and how these vary by key demographic factors: employment and partnership status...
June 2016: Demography
https://www.readbyqxmd.com/read/27089541/combination-drug-products-for-hiv-a-word-of-caution-for-the-transplant-clinician
#15
S J Patel, S A Kuten, W L Musick, A O Gaber, H P Monsour, R J Knight
Modern-day treatment regimens for human immunodeficiency virus (HIV) are not only highly effective, but are now more often available as convenient fixed-dose combination products. Furthermore, as medication adherence is of utmost importance in this setting, national guidelines endorse the use of such products. Transplant providers of HIV-infected patients will undoubtedly encounter these products, some of which contain medications known to drastically alter the metabolism of certain immunosuppressants. Herein, we describe an instance of drug interaction-induced calcineurin inhibitor (CNI) nephrotoxicity in a renal transplant recipient being started on a cobicistat-containing combination product for HIV...
August 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/26959510/frequency-and-impact-of-suboptimal-immune-recovery-on-first-line-antiretroviral-therapy-within-the-international-epidemiologic-databases-to-evaluate-aids-in-east-africa
#16
Damalie Nakanjako, Agnes N Kiragga, Beverly S Musick, Constantin T Yiannoutsos, Kara Wools-Kaloustian, Lameck Diero, Patrick Oyaro, Emanuel Lugina, John C Ssali, Andrew Kambugu, Philippa Easterbrook
OBJECTIVE: To describe patterns of suboptimal immune recovery (SO-IR) and associated HIV-related-illnesses during the first 5 years following first-line antiretroviral therapy (ART) initiation across seven ART sites in East Africa. DESIGN: Retrospective analysis of data from seven ART clinical sites (three Uganda, two Kenya and two Tanzania). METHODS: SO-IR was described by proportions of ART-treated adults with CD4 cell counts less than 200, less than 350 and less than 500 cells/μl...
July 31, 2016: AIDS
https://www.readbyqxmd.com/read/26910499/untangling-the-relationship-between-antiretroviral-therapy-use-and-incident-pregnancy-a-marginal-structural-model-analysis-using-data-from-47-313-hiv-positive-women-in-east-africa
#17
Batya Elul, Kara K Wools-Kaloustian, Yingfeng Wu, Beverly S Musick, Harriet Nuwagaba-Biribonwoha, Denis Nash, Samuel Ayaya, Elizabeth Bukusi, Pius Okong, Juliana Otieno, Deo Wabwire, Andrew Kambugu, Constantin T Yiannoutsos
BACKGROUND: Scale-up of triple-drug antiretroviral therapy (ART) in Africa has transformed the context of childbearing for HIV-positive women and may impact pregnancy incidence in HIV programs. METHODS: Using observational data from 47,313 HIV-positive women enrolled at 26 HIV clinics in Kenya and Uganda between 2001 and 2009, we calculated the crude cumulative incidence of pregnancy for the pre-ART and on-ART periods. The causal effect of ART use on incident pregnancy was assessed using inverse probability weighted marginal structural models, and the relationship was further explored in multivariable Cox models...
July 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/26910387/implementation-and-operational-research-declining-tuberculosis-incidence-among-people-receiving-hiv-care-and-treatment-services-in-east-africa-2007-2012
#18
Suzue Saito, Philani Mpofu, E Jane Carter, Lameck Diero, Kara K Wools-Kaloustian, Constantin T Yiannoutsos, Musick S Beverly, Simon Tsiouris, Geoffrey R Somi, John Ssali, Denis Nash, Batya Elul
BACKGROUND: Antiretroviral therapy (ART) reduces the risk of Tuberculosis (TB) among people living with HIV (PLWH). With ART scale-up in sub-Saharan Africa over the past decade, incidence of TB among PLWH engaged in HIV care is predicted to decline. METHODS: We conducted a retrospective analysis of routine clinical data from 168,330 PLWH receiving care at 35 facilities in Kenya, Tanzania, and Uganda during 2003-2012, participating in the East African region of the International Epidemiologic Databases to Evaluate AIDS...
April 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/26876514/critical-assessment-and-ramifications-of-a-purported-marine-trophic-cascade
#19
R Dean Grubbs, John K Carlson, Jason G Romine, Tobey H Curtis, W David McElroy, Camilla T McCandless, Charles F Cotton, John A Musick
When identifying potential trophic cascades, it is important to clearly establish the trophic linkages between predators and prey with respect to temporal abundance, demographics, distribution, and diet. In the northwest Atlantic Ocean, the depletion of large coastal sharks was thought to trigger a trophic cascade whereby predation release resulted in increased cownose ray abundance, which then caused increased predation on and subsequent collapse of commercial bivalve stocks. These claims were used to justify the development of a predator-control fishery for cownose rays, the "Save the Bay, Eat a Ray" fishery, to reduce predation on commercial bivalves...
February 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26823008/a-prospective-ascertainment-of-cancer-incidence-in-sub-saharan-africa-the-case-of-kaposi-sarcoma
#20
MULTICENTER STUDY
Aggrey Semeere, Megan Wenger, Naftali Busakhala, Nathan Buziba, Mwebesa Bwana, Winnie Muyindike, Erin Amerson, Toby Maurer, Timothy McCalmont, Philip LeBoit, Beverly Musick, Constantin Yiannoutsos, Robert Lukande, Barbara Castelnuovo, Miriam Laker-Oketta, Andrew Kambugu, David Glidden, Kara Wools-Kaloustian, Jeffrey Martin
In resource-limited areas, such as sub-Saharan Africa, problems in accurate cancer case ascertainment and enumeration of the at-risk population make it difficult to estimate cancer incidence. We took advantage of a large well-enumerated healthcare system to estimate the incidence of Kaposi sarcoma (KS), a cancer which has become prominent in the HIV era and whose incidence may be changing with the rollout of antiretroviral therapy (ART). To achieve this, we evaluated HIV-infected adults receiving care between 2007 and 2012 at any of three medical centers in Kenya and Uganda that participate in the East Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) Consortium...
May 2016: Cancer Medicine
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