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https://www.readbyqxmd.com/read/27900247/use-of-autologous-platelet-rich-fibrin-in-osseous-regeneration-after-cystic-enucleation-a-clinical-study
#1
Manzoor Dar, Tajamul Hakim, Ajaz Shah, Latief Najar, Gowhar Yaqoob, Faiqah Lanker
AIMS AND OBJECTIVES: The aim of this study was to evaluate the efficacy of PRF in osseous regeneration after enucleation of cystic lesions. The objectives of this study were as follows: (1) to evaluate osseous regeneration radiographically with the use of PRF in intrabony defects after cystic enucleation. (2) To evaluate the degree of bone density in intrabony defects with the use of PRF postoperatively after 1st, 3rd, and 6th months. SUBJECTS AND METHODS: 20 cases of cystic lesions were treated using PRF after cystic enucleation...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27878265/synergistic-effects-of-overexpression-of-bmp%C3%A2-2-and-tgf%C3%A2-%C3%AE-3-on-osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells
#2
Yilin Wang, Tian He, Jie Liu, Hongzhi Liu, Lugang Zhou, Wei Hao, Yujie Sun, Xin Wang
Bone morphogenetic protein 2 (BMP-2) and transforming growth factor β (TGF-β) isoforms are important in advancing bone regeneration. The aim of the present study was to investigate the positive and reciprocal effect of TGF‑β3, one of the three TGF‑β isoforms, on BMP‑2 in promoting osteogenic differentiation. Exogenous BMP‑2 and TGF‑β3 genes were separately, and in combination, overexpressed in rabbit bone marrow‑derived mesenchymal stem cells (rBMSCs). Expression levels of BMP‑2 and TGF‑β3 were evaluated using reverse‑transcription‑polymerase chain reaction (RT‑PCR) and Western blotting assays...
November 22, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27875512/single-tooth-osteotomy-combined-wide-linear-corticotomy-under-local-anesthesia-for-correcting-anterior-protrusion-with-ectopically-erupted-canine
#3
Nur Serife Iskenderoglu, Byung-Joon Choi, Kyung Won Seo, Yeon-Ji Lee, Baek-Soo Lee, Seong-Hun Kim
BACKGROUNDS: This article presents the alternative surgical treatments of both anterior protrusion by carrying out retraction on mandibular anterior fragment, meanwhile applying retraction force on maxilla anterior teeth and ectopically erupted canine with using platelet-rich fibrin (PRF). METHODS: Anterior segmental osteotomy was combined with linear corticotomy under local anesthesia. The correction of right ectopic canine was achieved through 2 stages. First, dento-osseous osteotomy on palatal side was performed...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27865631/the-influence-of-cortical-bone-perforation-on-guided-bone-regeneration-in-humans
#4
S A Danesh-Sani, D Tarnow, J K Yip, R Mojaver
The purpose of this study was to evaluate the effect of cortical bone perforation on angiogenesis and osteogenesis of the augmented ridge in guided bone regeneration. Eighteen patients who had osseous defects in the mandible were selected. In the test group (n=9), alveolar cortical bone in the area of regeneration was perforated. No decortication was performed in the control group (n=9). Subsequently, defects were augmented by guided bone regeneration using resorbable membrane and bovine bone. After a healing period of 7 months, trephine cores were harvested for histological and histomorphometric analysis of the grafted areas...
November 16, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27859491/origination-of-antlerogenesis
#5
Nicola S Heckeberg
Antlers are unique appendages. They are shed and rebuilt at intervals, and are synapomorphic for all living Cervidae (except for the Chinese water deer, Hydropotes inermis, in which they have presumably been lost). The antlerogenic process is controlled by a complex interaction of fluctuating levels of several hormones, most importantly testosterone. The oldest antler remains are recorded from the early Miocene; these have been interpreted as non-deciduous appendages because of supposed permanent skin coverage and the lack of a burr (a well-developed osseous protuberance around the base of the antler, which is always present in extant cervids)...
November 17, 2016: Journal of Morphology
https://www.readbyqxmd.com/read/27845276/3d-scaffold-with-effective-multidrug-sequential-release-against-bacteria-biofilm
#6
Rafaela García-Alvarez, Isabel Izquierdo-Barba, María Vallet-Regí
Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved with the design of 3D implants, which combine the merits of osseous regeneration and local multidrug therapy so as to avoid bacterial growth, drug resistance and the feared side effects. Herein, hierarchical 3D multidrug scaffolds based on nanocomposite bioceramic and polyvinyl alcohol (PVA) prepared by rapid prototyping with an external coating of gelatin-glutaraldehyde (Gel-Glu) have been fabricated...
November 11, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27824330/effect-of-sustained-pdgf-non-viral-gene-delivery-on-repair-of-tooth-supporting-bone-defects
#7
A B Plonka, B Khorsand, N Yu, J V Sugai, A K Salem, W V Giannobile, S Elangovan
Recombinant human platelet-derived growth factor-BB (rhPDGF-BB) promotes soft tissue and bone healing, and is FDA-approved for treatment of diabetic ulcers and periodontal defects. The short half-life of topical rhPDGF-BB protein application necessitates bolus, high-dose delivery. Gene therapy enables sustained local growth factor production. A novel gene activated matrix delivering polyplexes of polyethylenimine (PEI)-plasmid DNA (pDNA) encoding PDGF was evaluated for promotion of periodontal wound repair in vivo...
November 8, 2016: Gene Therapy
https://www.readbyqxmd.com/read/27790579/pure-titanium-membrane-ultra-ti-%C3%A2-in-the-treatment-of-periodontal-osseous-defects-a-split-mouth-comparative-study
#8
Rashmi Khanna, Rajeev Khanna, Nilesh Dinesh Pardhe, Nancy Srivastava, Manas Bajpai, Shailendra Gupta
INTRODUCTION: Although many different types of Guided Tissue Regeneration (GTR) membranes (resorbable/non-resorbable, including titanium mesh) have been used in the field of Periodontics till now, but this is the first and only clinical study testing the effectiveness of an ultra thin pure Titanium Membrane (Ultra Ti) as a GTR membrane in infra-bony periodontal defects. AIM: To compare the efficacy of GTR in intra-bony defects with newly introduced non-resorbable barrier membrane, made of titanium called "Ultra-Ti (®) GTR Membrane" versus open flap debridement...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27790578/clinical-evaluation-of-insulin-like-growth-factor-i-and-vascular-endothelial-growth-factor-with-alloplastic-bone-graft-material-in-the-management-of-human-two-wall-intra-osseous-defects
#9
Renu Devi, Jaya Dixit
INTRODUCTION: In recent years, emphasis on the use of growth factors for periodontal healing is gaining great momentum. Several growth factors showed promising results in periodontal regeneration. AIM: This study was designed to compare the clinical outcomes of 0.8μg recombinant human Vascular Endothelial Growth Factor (rh-VEGF) and 10μg recombinant human Insulin Like Growth Factor-I (rh-IGF-I) with β-Tricalcium Phosphate (β-TCP) and Polylactide-Polyglycolide Acid (PLGA) membrane in two wall intra-osseous defects...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27727104/differential-modulation-of-zoledronate-and-etidronate-in-osseous-healing-of-an-extracted-socket-and-tibia-defect
#10
Shin Saeng Lim, Beomseok Lee, In Sook Kim, Soon Jung Hwang
OBJECTIVES: Osteonecrosis of the jaw has been increasing after dentoalveolar surgery in patients treated with an antiresorptive bisphosphonate (BP), especially strong zoledronate (ZA). The pathophysiology underlying why osteonecrosis occurs exclusively in the jaw bone remains unclear. This study investigated skeletal site-specific bone healing during the use of BPs to explore the preferential incidence of osteonecrosis of the jaw bone. STUDY DESIGN: Extraction of mandibular molar and creation of a tibia defect were performed in rats 2 weeks after weekly intravenous injections with the potent ZA and the weaker BP etidronate...
August 18, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27722231/strontium-folate-loaded-biohybrid-scaffolds-seeded-with-dental-pulp-stem-cells-induce-in-vivo-bone-regeneration-in-critical-sized-defects
#11
Marcela Martin-Del-Campo, Raul Rosales-Ibañez, Keila Alvarado, Jose G Sampedro, Christian A Garcia-Sepulveda, Sanjukta Deb, Julio San Román, Luis Rojo
Strontium folate (SrFO) is a recently developed bone promoting agent with interest in medical and pharmaceutical fields due to its improved features in comparison to current strontium based therapies for osteoporosis and other bone diseases. In this work SrFO derivative was synthesized and loaded into biohybrid scaffolds obtained through lyophilisation of semi-interpenetrating networks of chitosan polyethylene glycol dimethacrylate and beta tri-calcium phosphate (βTCP) fabricated using free radical polymerization...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27712189/a-computational-model-of-osteochondral-defect-repair-following-implantation-of-stem-cell-laden-multiphase-scaffolds
#12
Adam O'Reilly, Daniel John Kelly
Developing successful tissue engineering strategies requires an understanding of how cells within an implanted scaffold interacts with the host environment. The objective of this study was to use a computational mechanobiological model to explore how the design of a cell laden scaffold influences the spatial formation of cartilage and bone within an osteochondral defect. Tissue differentiation was predicted using a previously developed model in which cell fate depends on the local oxygen tension and the mechanical environment within a damaged joint...
October 6, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27673535/regulation-of-adsc-osteoinductive-potential-using-notch-pathway-inhibition-and-gene-rescue-a-potential-on-off-switch-for-clinical-applications-in-bone-formation-and-reconstructive-efforts
#13
Denver M Lough, Christopher Chambers, Gunter Germann, Ruben Bueno, Joel Reichensperger, Edward Swanson, Mary Dyer, Lisa Cox, Carrie Harrison, Michael W Neumeister
BACKGROUND: Although there has been tremendous research in the ability of mesenchymal-derived adipose derived stem cells (ADSCs) to form bone, less is known regarding the molecular mechanisms that regulate the osteogenic potential of ADSCs. Notch, which consists of a key family of regulatory ligands involved in bone formation, is expressed in the bone marrow-derived mesenchymal stem cell niche and is critical for proliferation, migration, and ultimately osseous differentiation. The authors investigate how Notch impacts ADSC proliferation and osteogenic differentiation to determine a translatable application of these cells in bone regeneration...
October 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27616585/microarray-gene-expression-during-early-healing-of-gbr-treated-calvarial-critical-size-defects
#14
R Al-Kattan, M Retzepi, E Calciolari, N Donos
OBJECTIVES: To investigate the gene expression and molecular pathways implicated in the regulation of the osseous healing process following guided bone regeneration (GBR). MATERIAL AND METHODS: Six 6-month-old Wistar male rats were used. Standardized 5-mm critical size defects were created in the parietal bones of each animal and treated with an extracranial and intracranial ePTFE membrane, according to the GBR principle. Three animals were randomly sacrificed after 7 and 15 days of healing...
September 11, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27604654/influence-of-single-and-binary-doping-of-strontium-and-lithium-on-in-vivo-biological-properties-of-bioactive-glass-scaffolds
#15
Pintu Kumar Khan, Arnab Mahato, Biswanath Kundu, Samit K Nandi, Prasenjit Mukherjee, Someswar Datta, Soumya Sarkar, Jayanta Mukherjee, Shalini Nath, Vamsi K Balla, Chitra Mandal
Effects of strontium and lithium ion doping on the biological properties of bioactive glass (BAG) porous scaffolds have been checked in vitro and in vivo. BAG scaffolds were prepared by conventional glass melting route and subsequently, scaffolds were produced by evaporation of fugitive pore formers. After thorough physico-chemical and in vitro cell characterization, scaffolds were used for pre-clinical study. Soft and hard tissue formation in a rabbit femoral defect model after 2 and 4 months, were assessed using different tools...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27593787/nerve-t%C3%A4-ssue-prefabr%C3%A4-cat%C3%A4-on-%C3%A4-ns%C3%A4-de-the-rat-femoral-bone-does-%C3%A4-t-work
#16
Zühtü Özbek, Atacan Emre Koçman, Orhan Özatik, Erdem Söztutar, Emre Özkara, Aydan Köse, Ali Arslantaş, Cengiz Çetin
AIM: This study was aimed to investigate whether nerve regeneration can be induced in the tubular bone between distal and proximal cut nerve ends. MATERIAL AND METHODS: Twenty adult Wistar rats were used for the study. Rats were divided in three groups; femoral bone conduit group, nerve transection group, sham group. Sciatic nerve was surgically cut and from both ends inserted into the adjacent femoral bone tunnel at femoral bone conduit group. The sciatic nerve was cut transversely at nerve transection group...
December 7, 2015: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27580862/the-effect-of-experimental-osteoporosis-on-bone-regeneration-part-2-proteomics-results
#17
E Calciolari, N Mardas, X Dereka, A K Anagnostopoulos, G T Tsangaris, N Donos
OBJECTIVES: To identify and describe protein expression in a Wistar rat calvarial critical size defect (CSD) model following treatment with guided bone regeneration in healthy and osteoporotic conditions. MATERIAL AND METHODS: Thirty-six 10-month-old female Wistar rats were used. Half of them were ovariectomized (OVX) and fed with a low-calcium diet to induce an osteoporotic-like status. In each animal of both groups, two 5-mm calvarial CSDs were treated with deproteinized bovine bone mineral graft particles and a bilayer collagen membrane...
September 1, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27514097/-the-bone-defect-healing-under-the-influence-of-radial-extracorporeal-shock-wave-therapy-in-experiment
#18
G I Gertsen, Se-Fey, R M Ostapchuk, A V Lesovoy, V V Zherebchuk
In experiment on 24 rabbits the processes of reparative osteogenesis in perforated defect of proximal tibial metaphysis under the influence of extracorporeal shock-wave therapy were studied. In accordance to data of clinical, roentgenological and morphological investiagations, conducted in terms 5, 15, 30 and 45 days of observation, there was established, that under the influence of extracorporeal shock-wave therapy in the bone marrow in the traumatic region a vasodilatation, as well as the blood cells exit from capillaries and sinusoid vessels with creation of massive regions of osseous endostal regenerate, guaranteeing the tibial integrity restoration, occurs...
March 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/27491089/real-time-assessment-of-osseous-tissue-changes-after-guided-bone-regeneration
#19
EDITORIAL
Khalid Al-Hezaimi
No abstract text is available yet for this article.
2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27458901/demineralized-bone-matrix-fibers-formable-as-general-and-custom-3d-printed-mold-based-implants-for-promoting-bone-regeneration
#20
Rudy U Rodriguez, Nathan Kemper, Erick Breathwaite, Sucharita M Dutta, Erin L Hsu, Wellington K Hsu, Michael P Francis
INTRODUCTION: Bone repair frequently requires time-consuming implant construction, particularly when using un-formed implants with poor handling properties. We therefore developed osteoinductive, micro-fibrous surface patterned demineralized bone matrix (DBM) fibers for engineering both defect-matched and general three-dimensional implants. METHODS AND RESULTS: Implant molds were filled with demineralized human cortical bone fibers there were compressed and lyophilized, forming mechanically strong shaped DBM scaffolds...
2016: Biofabrication
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