keyword
MENU ▼
Read by QxMD icon Read
search

Osseous regenerate

keyword
https://www.readbyqxmd.com/read/29777616/regenerative-endodontics-a-review
#1
REVIEW
S G Kim, M Malek, A Sigurdsson, L M Lin, B Kahler
The European Society of Endodontology and the American Association for Endodontists have released position statements and clinical considerations for regenerative endodontics. There is increasing literature on this field since the initial reports of Iwaya et al. (2001) and Banchs & Trope (2004). Endogenous stem cells from an induced periapical bleeding and scaffolds using blood clot, platelet rich plasma or platelet rich fibrin have been utilized in regenerative endodontics. This approach has been described as a 'paradigm shift" and considered the first treatment option for immature teeth with pulp necrosis...
May 19, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29776600/contrast-enhanced-ultrasound-quantifies-the-perfusion-within-tibial-non-unions-and-predicts-the-outcome-of-revision-surgery
#2
Daniel Krammer, Gerhard Schmidmaier, Marc-André Weber, Julian Doll, Christoph Rehnitz, Christian Fischer
Vascularity is one of the factors determining successful bone regeneration. This prospective study focused on quantifying the microperfusion of tibial non-unions with contrast-enhanced ultrasound (CEUS) 12 wk after revision surgery and comparing it with the osseous consolidation at a maximum of 24 mo assessed with standard radiography and computed tomography. Of 36 patients with tibial non-unions, 28 (77.8%) manifested consolidation, and 8 patients required further revision surgery. CEUS revealed significantly higher perfusion in consolidated versus persistent non-unions for all quantification parameters (e...
May 15, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29753427/gelfoam-haemostatic-agent-with-or-without-autologous-bone-marrow-derived-stem-cells-for-the-regeneration-of-critical-size-mandibular-defects-in-the-rabbit
#3
A A Ashour, M Zaghloul, W Mahmoud, M E Helal, M E Grawish
This study evaluated the effect of Gelfoam sponge with and without autologous bone marrow-derived stem cells (BMSCs) on bone regeneration in critical-size mandibular defects. The study involved 56 New Zealand rabbits assigned to four groups (14 in each). The osseous defects in group I were irrigated with normal saline, those in group II were grafted with autogenous tibial bone, and those in group III were filled with Gelfoam sponge. Group IV defects were treated as for group III, but the interface between the Gelfoam sponge and bone surface was injected with BMSCs...
May 9, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29713178/safety-study-is-there-a-pathologic-igf-1-pdgf-and-tgf-%C3%AE-cytokine-expression-caused-by-adjunct-bmp-7-in-tibial-and-femoral-non-union-therapy
#4
Christian Fischer, Christian Reiner, Gerhard Schmidmaier, Julian Doll, Christopher Child, Paul Alfred Grützner, Bahram Biglari, Sonja Boxriker, Arash Moghaddam
Background: In this prospective safety study, we investigated if the characteristic cytokine expression during bone regeneration is manipulated by the local application of bone morphogenetic protein-7 (BMP-7) in non-union surgery. Therefore, the levels of insulin like growth factor 1 (IGF-1), platelet-derived growth factor AB (PDGF-AB) and transforming growth factor beta (TGF-β) were compared between patients with the gold standard use of autologous bone graft (ABG) and those with additional application of BMP-7 as part of the diamond concept...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29682573/antibody-mediated-osseous-regeneration-for-bone-tissue-engineering-in-canine-segmental-defects
#5
A Khojasteh, S Hosseinpour, M M Dehghan, F Mashhadiabbas, M Rezai Rad, S Ansari, S Farzad Mohajeri, H H Zadeh
Among many applications of therapeutic monoclonal antibodies (mAbs), a unique approach for regenerative medicine has entailed antibody-mediated osseous regeneration (AMOR). In an effort to identify a clinically relevant model of craniofacial defect, the present study investigated the efficacy of mAb specific for bone morphogenetic protein- (BMP-) 2 to repair canine segmental mandibular continuity defect model. Accordingly, a 15 mm unilateral segmental defect was created in mandible and fixated with a titanium plate...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29619368/the-chondro-osseous-continuum-is-it-possible-to-unlock-the-potential-assigned-within
#6
REVIEW
Behzad Javaheri, Soraia P Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A Pitsillides
Endochondral ossification (EO), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix synthesis, calcification, and angiogenesis, followed by osteoblast-mediated ossification. This developmental sequence reappears during fracture repair and in osteoarthritic etiopathology. These similarities suggest that EO, and the cells involved, are of great clinical importance for bone regeneration as it could provide novel targeted approaches to increase specific signaling to promote fracture healing, and if regulated appropriately in the treatment of osteoarthritis...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29608574/healing-potentials-of-polymethylmethacrylate-bone-cement-combined-with-platelet-gel-in-the-critical-sized-radial-bone-defect-of-rats
#7
Ahmad Oryan, Soodeh Alidadi, Amin Bigham-Sadegh, Ali Moshiri
Polymethylmethacrylate (PMMA) is the most commonly used filler material that lacks biological properties and osteoconductivity or osteoinductivity. Platelet gel (PG) is a typical source of growth factors, cytokines and molecules efficient for bone formation and remodeling. The aim of this study was to evaluate bone healing and regeneration of bone defect in rat model by combining PMMA with PG. A total of 50 defects were created in the diaphysis of the radii of 25 male Sprague-Dawley rats. These defects were randomly divided into five groups (n = 10 defects for each group) and treated by autograft, plain PMMA, PG and PMMA-PG or left untreated...
2018: PloS One
https://www.readbyqxmd.com/read/29599032/femoral-bone-restoration-patterns-in-revision-total-hip-arthroplasty-using-distally-fixed-modular-tapered-titanium-stems-and-an-extended-trochanteric-osteotomy-approach
#8
Andreas Ladurner, Vilijam Zdravkovic, Karl Grob
BACKGROUND: Mechanical failure of modular revision stems is a serious complication in revision total hip arthroplasty. The lack of adequate osseous support to the proximal component, especially in cases of an extended trochanteric osteotomy approach, is considered a risk factor for stem failure. In this study, we analyze proximal bone regeneration patterns in patients undergoing revision total hip arthroplasty for aseptic stem loosening through an extended trochanteric osteotomy approach using an uncemented dual modular stem...
February 26, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29553500/a-mouse-model-of-orthopedic-surgery-to-study-postoperative-cognitive-dysfunction-and-tissue-regeneration
#9
Chao Xiong, Zhiquan Zhang, Gurpreet S Baht, Niccolo Terrando
Surgery is commonly used to improve and maintain quality of life. Unfortunately, in vulnerable patients such as the elderly, complications may occur and significantly diminish the outcome. Indeed, after routine orthopedic surgery to repair a fracture, as many as 50% of elderly patients suffer from neurologic complications like delirium. Also, the capacity to heal and regenerate tissue after surgery decreases with age, and can impact the quality of fracture repair and even osseous integration of implants. Thus, a better understanding of mechanisms that drive these age-dependent changes could provide strategic targets to minimize risk for such complications and optimize outcomes...
February 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29547544/bioactive-glasses-from-parent-45s5-composition-to-scaffold-assisted-tissue-healing-therapies
#10
REVIEW
Elisa Fiume, Jacopo Barberi, Enrica Verné, Francesco Baino
Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone defects, each one with its own advantages and drawbacks. As a result, the need for synthetic bone grafts is still a remarkable clinical challenge since more than 1 million bone-graft surgical operations are annually performed worldwide...
March 16, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29504816/guided-bone-regeneration-of-femoral-segmental-defects-using-equine-bone-graft-an-in-vivo-micro-computed-tomographic-study-in-rats
#11
Mohammed Awadh Binsalah, Sundar Ramalingam, Mohammed Alkindi, Nasser Nooh, Khalid Al-Hezaimi
BACKGROUND AND OBJECTIVES: Guided bone regeneration (GBR) is commonly used for osseous defect reconstruction. The objective of this study was to evaluate in real-time (in-vivo) the efficacy of equine bone graft for GBR in segmental critical-size defects (CSD) of the femur in a rat model. MATERIALS AND METHODS: Following ethical approval, 30 male Wistar-Albino rats (age 12-14 months/weight 450-500 grams) were included. Under general-anesthesia, a mid-diaphyseal segmental CSD (5 mm) was created in the femur and stabilized using titanium Miniplate(4 holes,1...
March 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29492412/the-impact-of-calcium-hydroxide-on-the-osteoinductive-capacity-of-demineralized-freeze-dried-bone-allograft-an-in-vitro-study
#12
Hengameh Khosropanah, Nazila Lashkarizadeh, Maryam Ayatollahi, Maryam Kaviani, Zohreh Mostafavipour
Statement of the Problem: A great challenge in periodontal therapy is the regeneration enhancement of osseous defects through applying osteoinductive materials. Demineralized freeze-dried bone allograft (DFDBA) has already been introduced as an allograft with osteoconductive and variable osteoinductive properties. Calcium hydroxide [Ca(OH)2 ] is an available well-known material in dentistry, which induces hard tissue formation. Purpose: This study evaluated the efficiency of combination of DFDBA and Ca(OH)2 in improving the quality of osteoinduction of DFDBA...
March 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29478209/muscle-pedicle-bone-grafting-using-the-anterior-one-third-of-the-gluteus-medius-attached-to-the-greater-trochanter-for-treatment-of-association-research-circulation-osseous-stage-ii-osteonecrosis-of-the-femoral-head
#13
Kyu-Jin Cho, Kyung-Soon Park, Taek-Rim Yoon
PURPOSE: The aim of this study was to evaluate the effectiveness of our technique on further collapse of the femoral head in Association Research Circulation Osseous (ARCO) stage II, patient's functional improvements, and analyze the survival rate of the affected hip. METHODS: Between June 2007 and March 2015, 24 hips diagnosed with osteonecrosis of the femoral head (ONFH) were treated with our muscle pedicle bone grafting (MPBG) technique using anterior one-third of gluteus medius attached to the greater trochanter...
February 24, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29441709/multifunctional-cell-instructive-silk-bioactive-glass-composite-reinforced-scaffolds-toward-osteoinductive-proangiogenic-and-resorbable-bone-grafts
#14
Joseph Christakiran Moses, Samit Kumar Nandi, Biman B Mandal
The successful regeneration of large volume bone defects necessitates the use of proangiogenic and resorbable scaffolding matrix. Impaired and slow ingrowth of host vasculature within implanted grafts greatly compromises its effective osseointegration. By addressing this, it is demonstrated that the use of copper doped bioactive glass functionalizes silk microfiber reinforcements to improve the physicochemical and osteoinductive properties of two silk scaffolding matrices (mulberry Bombyx mori and non-mulberry Antheraea assama) employed in the study...
February 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29436646/in-vitro-evaluation-of-a-bone-morphogenetic-protein%C3%A2-2-nanometer-hydroxyapatite-collagen-scaffold-for-bone-regeneration
#15
Yue Cai, Shuang Tong, Ran Zhang, Tong Zhu, Xukai Wang
Scaffold fabrication and biocompatibility are crucial for successful bone tissue engineering. Nanometer hydroxyapatite (nHAP) combined with collagen (COL) is frequently utilized as a suitable osseous scaffold material. Furthermore, growth factors, including bone morphogenetic protein‑2 (BMP‑2), are used to enhance the scaffold properties. The present study used blending and freeze‑drying methods to develop a BMP‑2‑nHAP‑COL scaffold. An ELISA was performed to determine the BMP‑2 release rate from the scaffold...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29398865/tooth-for-a-tooth-tissue-engineering-made-easy-at-dental-chairside
#16
Vandana Kharidhi Laxman, Rajendra Gururao Desai
Background: Stem cells are unspecialized, multipotent cells which can differentiate into different cell types. The human periodontal ligament encloses subpopulation of Periodontal Ligament Stem Cells (PDLSCs) which are able to regenerate the periodontium by differentiating into various cells of PDL. Literature have shown the promising results of periodontal regeneration by exvivo cultured transplantation of PDLSCs into the osseous defects. Methods: Based on current literature on use of ex vivo culture and associated problems, a novel technique is being presented , Stem cell application in periodontal regeneration (SAI-PRT) which uses autologous PDLSCs along with its niche adhering to extracted tooth root for direct application using gelatin sponge as scaffold in regeneration of intrabony periodontal defect bypassing ex-vivo culture...
March 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29388788/correction-of-large-oro-antral-communications-from-previously-failed-implant-treatment-reconstruction-of-hard-and-soft-tissues
#17
Paul S Petrungaro, Santiago Gonzalez, Carlos Villegas
As dental implants become more popular for the treatment of partial and total edentulism and treatment of "terminal dentitions," techniques for the management of the atrophic posterior maxillae continue to evolve. Although dental implants carry a high success rate long term, attention must be given to the growing numbers of revisions or retreatment of cases that have had previous dental implant treatment and/or advanced bone replacement procedures that, due to either poor patient compliance, iatrogenic error, or poor quality of the pre-existing alveolar and/or soft tissues, have led to large osseous defects, possibly with deficient soft-tissue volume...
February 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29386818/efficacy-of-decalcified-freeze-dried-bone-allograft-in-the-regeneration-of-small-osseous-defect-a-comparative-study
#18
Yashmi Jaiswal, Sanjeev Kumar, Vijay Mishra, Puneet Bansal, Kumar Rakshak Anand, Sukumar Singh
Aim: To access the efficacy of decalcified freeze-dried bone allograft (DFDBA) in the regeneration of bone following small osseous defect in minor oral surgery. Objectives: To evaluate the ability of DFDBA to enhance the rate of wound healing and assess radiographic bone density, pain, and infection preoperatively and postoperatively. Materials and Methods: Twenty patients with cysts were assessed. Ten patients were filled with DFDBA (Group 1) and ten without bone graft (Group 2), respectively...
July 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/29303409/clinical-safety-of-a-new-synthetic-resorbable-dental-membrane-a-case-series-study
#19
Hélène Martin-Thomé, David Bourdin, Nicolas Strube, Afchine Saffarzadeh, Jean-Francois Morlock, Guillaume Campard, Charles Evanno, Alain Hoornaert, Pierre Layrolle
Dental membranes are commonly used in oral and maxillofacial surgery for the regeneration of small osseous defects. A new synthetic resorbable membrane has recently demonstrated its biocompatibility and bone regeneration capacity in preclinical studies. This membrane is made of poly(D,L-lactic/glycolic acid 85/15), has a bi-layered structure with a dense film to prevent gingival epithelial cell invasion, and a microfibrous layer to support osteogenic cells and bone healing. This membrane completely degrades by hydrolysis in 4 to 6 months without signs of inflammation...
April 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29286432/in-vivo-evaluation-of-fracture-callus-development-during-bone-healing-in-mice-using-an-mri-compatible-osteosynthesis-device-for-the-mouse-femur
#20
Melanie Haffner-Luntzer, Fabian Müller-Graf, Romano Matthys, Alireza Abaei, René Jonas, Florian Gebhard, Volker Rasche, Anita Ignatius
Endochondral fracture healing is a complex process involving the development of fibrous, cartilaginous, and osseous tissue in the fracture callus. The amount of the different tissues in the callus provides important information on the fracture healing progress. Available in vivo techniques to longitudinally monitor the callus tissue development in preclinical fracture-healing studies using small animals include digital radiography and µCT imaging. However, both techniques are only able to distinguish between mineralized and non-mineralized tissue...
November 14, 2017: Journal of Visualized Experiments: JoVE
keyword
keyword
103203
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"