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https://www.readbyqxmd.com/read/28893033/comparative-evaluation-of-bioactive-glass-putty-and-platelet-rich-fibrin-in-the-treatment-of-human-periodontal-intrabony-defects-a-randomized-control-trial
#1
Akbar Naqvi, D Gopalakrishnan, Meenu Taneja Bhasin, Nilima Sharma, Khushtar Haider, Santosh Martande
INTRODUCTION: Platelet-Rich Fibrin (PRF) and bioactive glass putty have been shown to be effective in promoting reduction in probing depth, gain in clinical attachment, and defect fill in intrabony periodontal defects. The individual role played by bioactive glass putty in combination with PRF is yet to be elucidated. AIM: To compare the clinical effectiveness of the combination of PRF and bioactive glass putty and bioactive glass putty alone as regenerative techniques for intrabony defects in humans...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28875278/investigation-of-peri-implant-tissue-conditions-and-peri-implant-tissue-stability-in-implants-placed-with-simultaneous-augmentation-procedure-a-3-year-retrospective-follow-up-analysis-of-a-newly-developed-bone-level-implant-system
#2
Jonas Lorenz, Henriette Lerner, Robert A Sader, Shahram Ghanaati
BACKGROUND: Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. The aim of the present retrospective analysis was to assess peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure. METHODS: A total of 47 implants, which were placed simultaneously with a GBR procedure with a synthetic bone substitute material in 20 patients, were investigated clinically and radiologically at least 3 years after loading...
September 5, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28863592/numerical-evaluation-of-the-backward-propagating-acoustic-field-in-healing-long-bones
#3
Vassiliki T Potsika, Vasilios C Protopappas, Konstantinos N Grivas, Theodoros V Gortsas, Kay Raum, Demosthenes K Polyzos, Dimitrios I Fotiadis
The propagation of ultrasound in healing long bones induces complex scattering phenomena due to the interaction of an ultrasonic wave with the composite nature of callus and osseous tissues. This work presents numerical simulations of ultrasonic propagation in healing long bones using the boundary element method aiming to provide insight into the complex scattering mechanisms and better comprehend the state of bone regeneration. Numerical models of healing long bones are established based on scanning acoustic microscopy images from successive postoperative weeks considering the effect of the nonhomogeneous callus structure...
August 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28844964/regenerating-bone-with-bioactive-glass-scaffolds-a-review-of-in-vivo-studies-in-bone-defect-models
#4
REVIEW
Aiah A El-Rashidy, Judith A Roether, Leila Harhaus, Ulrich Kneser, Aldo R Boccaccini
Large bone defects resulting from fractures and disease are a medical concern, being often unable to heal spontaneously by the body's repair mechanisms. Bone tissue engineering (BTE) is a promising approach for treating bone defects through providing a template to guide osseous regeneration. 3D scaffolds with microstructure mimicking host bone are necessary in common BTE strategies. Bioactive glasses (BGs) attract researchers' attention as BTE scaffolds as they are osteoconductive and osteoinductive in certain formulations...
August 24, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28820320/autologous-platelet-rich-fibrin-in-the-treatment-of-3-wall-intrabony-defects-in-aggressive-periodontitis-a-randomized-controlled-clinical-trial
#5
Pavan Bajaj, Esha Agarwal, Nishanth S Rao, Savitha B Naik, A R Pradeep, Nitish Kalra, N Priyanka, Minal Kumari
BACKGROUND: Platelet rich fibrin (PRF), has recently found its application in osseous regeneration. The aim of present study is to explore the efficacy of PRF in treatment of intrabony defects in aggressive periodontitis. MATERIAL AND METHODS: 54 intrabony defects in 17 patients were treated either with autologous PRF with open flap debridement (OFD) or OFD alone. Clinical and radiological parameters such as probing depth (PD), clinical attachment level (CAL), intrabony defect depth and % defect change were recorded at baseline and 9 months postoperatively...
August 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28748054/autologous-periodontal-stem-cell-assistance-in-periodontal-regeneration-technique-sai-prt-in-the-treatment-of-periodontal-intrabony-defects-a-case-report-with-one-year-follow-up
#6
Vandana Kl, Haneet Ryana, Priyanka Jairaj Dalvi
Numerous animal and human studies have provided evidence supporting the belief that periodontal ligament stem cells (PDLSCs) can be harnessed for regeneration of periodontal tissues. Based on current literature on the use of ex vivo stem culture and associated problems, this case report describes a novel approach of direct application PDLSCs using stem cell assistance in periodontal regeneration technique (SAI-PRT) for the regeneration of intrabony periodontal defects bypassing ex vivo cultures. SAI-PRT has emerged as a constructive avenue in the treatment of periodontal osseous defects...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28736687/tissue-engineered-tendon-for-enthesis-regeneration-in-a-rat-rotator-cuff-model
#7
Michael J Smietana, Pablo Moncada-Larrotiz, Ellen M Arruda, Asheesh Bedi, Lisa M Larkin
Healing of rotator cuff (RC) injuries with current suture or augmented scaffold techniques fails to regenerate the enthesis and instead forms a weaker fibrovascular scar that is prone to subsequent failure. Regeneration of the enthesis is the key to improving clinical outcomes for RC injuries. We hypothesized that the utilization of our tissue-engineered tendon to repair either an acute or a chronic full-thickness supraspinatus tear would regenerate a functional enthesis and return the biomechanics of the tendon back to that found in native tissue...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28725934/-scaffold-based-bone-tissue-engineering
#8
REVIEW
B M Holzapfel, M Rudert, D W Hutmacher
Tissue engineering provides the possibility of regenerating damaged or lost osseous structures without the need for permanent implants. Within this context, biodegradable and bioresorbable scaffolds can provide structural and biomechanical stability until the body's own tissue can take over their function. Additive biomanufacturing makes it possible to design the scaffold's architectural characteristics to specifically guide tissue formation and regeneration. Its nano-, micro-, and macro-architectural properties can be tailored to ensure vascularization, oxygenation, nutrient supply, waste exchange, and eventually ossification not only in its periphery but also in its center, which is not in direct contact with osteogenic elements of the surrounding healthy tissue...
August 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28717292/conservative-management-of-unicystic-ameloblastoma-in-young-patients-a-prospective-single-center-trial-and-review-of-literature
#9
Mitsu Meshram, Lalit Sagarka, Jigar Dhuvad, Sonal Anchlia, Siddharth Vyas, Harsh Shah
AIMS: The study intends to evaluate the clinical outcome of treating young patients of unicystic ameloblastoma, by various conservative treatment modalities such as marsupialization, enucleation with bone curettage and aid in establishing sound treatment guidelines. MATERIALS AND METHODS: A case series of fifteen patients is presented of unicystic ameloblastoma, who presented to our Department over the past 6 years (2010-2015) and conservative method of treatment elected in all the patients...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28713017/intracellular-co-delivery-of-sr-ion-and-phenamil-drug-through-mesoporous-bioglass-nanocarriers-synergizes-bmp-signaling-and-tissue-mineralization
#10
Jung-Hwan Lee, Nandin Mandakhbayar, Ahmed El-Fiqi, Hae-Won Kim
Inducing differentiation and maturation of resident multipotent stem cells (MSCs) is an important strategy to regenerate hard tissues in mal-calcification conditions. Here we explore a co-delivery approach of therapeutic molecules comprised of ion and drug through a mesoporous bioglass nanoparticle (MBN) for this purpose. Recently, MBN has offered unique potential as a nanocarrier for hard tissues, in terms of high mesoporosity, bone bioactivity (and possibly degradability), tunable delivery of biomolecules, and ionic modification...
July 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28696960/sinus-floor-augmentation-with-ambient-blood-and-an-absorbable-collagen-sponge-a-prospective-pilot-clinical-study
#11
Antoine Berberi, Nabih Nader, Rita Bou Assaf, Hussein Fayyad-Kazan, Saad Khairalah, Nabil Moukarzel
PURPOSE: The aim of this study was to clinically, radiologically, and histologically evaluate a sinus augmentation technique using a resorbable collagen sponge to maintain space between the Schneiderian membrane and the residual crestal bone. MATERIALS AND METHODS: Patients with partially edentulous maxillae were clinically and radiographically evaluated for implant placement. A total of 10 consecutive patients with the bone height for implant placement (<4.0 mm) were enrolled in the study...
July 10, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28677589/regeneration-of-periapical-lesions-post-endodontic-treatment-and-periapical-surgeries-in-experimental-animals-utilizing-thermo-responsive-nano-%C3%AE-tricalcium-phosphate-chitosan-hydrogel-a-proof-of-concept
#12
Wafa I Abdel-Fattah, Salma Hassan El Ashry, Ghareib W Ali, Mohamed Aiad Abdel Hamid, Amina Gamal El-Din, Bassma El-Ashry
Using phosphate nanoparticles/polymeric hydrogels presents an interesting approach, especially concerning the reduced particle migration and enhanced biocompatibility. The current work aims to achieve a proof of concept for the development of a thermo-sensitive nano β-tricalcium phosphate (β-TCP)/chitosan (Cs)/glycerophosphate (Gl)/glyoxal (Gly) hydrogel to be applied in periapical surgeries post endodontic treatment. Physicochemical characterization using x-ray powder diffraction, Fourier transform infrared, TEM and SEM was performed...
July 5, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28672135/local-application-of-platelet-rich-fibrin-during-lower-third-molar-extraction-improves-treatment-outcomes
#13
REVIEW
Yun He, Junliang Chen, Yue Huang, Qin Pan, Minhai Nie
PURPOSE: Application of platelet-rich fibrin (PRF) during tooth extraction is able to accelerate wound healing, stimulate osseous and soft tissue regeneration, and reduce unwanted side effects. The aim of this meta-analysis was to investigate the effect of local application of PRF on controlling postoperative signs and symptoms after the extraction of an impacted lower third molar. MATERIALS AND METHODS: A systematic search of PubMed, Web of Science, Embase, and the Cochrane Library was performed to identify all studies published up to October 2016 that investigated the effect of PRF on lower third molar extraction...
June 8, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28629025/polycaprolactone-and-polycaprolactone-ceramic-based-3d-bioplotted-porous-scaffolds-for-bone-regeneration-a-comparative-study
#14
K K Gómez-Lizárraga, C Flores-Morales, M L Del Prado-Audelo, M A Álvarez-Pérez, M C Piña-Barba, C Escobedo
One of the critical challenges that scaffolding faces in the organ and tissue regeneration field lies in mimicking the structure, and the chemical and biological properties of natural tissue. A high-level control over the architecture, mechanical properties and composition of the materials in contact with cells is essential to overcome such challenge. Therefore, definition of the method, materials and parameters for the production of scaffolds during the fabrication stage is critical. With the recent emergence of rapid prototyping (RP), it is now possible to create three-dimensional (3D) scaffolds with the essential characteristics for the proliferation and regeneration of tissues, such as porosity, mechanical strength, pore size and pore interconnectivity, and biocompatibility...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28581710/biotransformation-of-silver-released-from-nanoparticle-coated-titanium-implants-revealed-in-regenerating-bone
#15
Hua Geng, Gowsihan Poologasundarampillai, Naomi Todd, Aine Devlin-Mullin, Katie L Moore, Zahra Golrokhi, James B Gilchrist, Eric Jones, Richard J Potter, Chris Sutcliffe, Marie O'Brien, David W L Hukins, Sarah Cartmell, Christopher A Mitchell, Peter D Lee
Antimicrobial silver nanoparticle coatings have attracted interest for reducing prosthetic joint infection. However, few studies report in vivo investigations of the biotransformation of silver nanoparticles within the regenerating tissue and its impact on bone formation. We present a longitudinal investigation of the osseointegration of silver nanoparticle-coated additive manufactured titanium implants in rat tibial defects. Correlative imaging at different time points using nanoscale secondary ion mass spectrometry, transmission electron microscopy (TEM), histomorphometry, and 3D X-ray microcomputed tomography provided quantitative insight from the nano- to macroscales...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28542343/bone-marrow-cell-extract-promotes-the-regeneration-of-irradiated-bone
#16
Guillaume Michel, Pauline Blery, Michaël Henoux, Jérôme Guicheux, Pierre Weiss, Sophie Brouard, Olivier Malard, Florent Espitalier
Mandibular osteoradionecrosis is a severe side effect of radiotherapy after the treatment of squamous cell carcinomas of the upper aerodigestive tract. As an alternative to its treatment by micro-anastomosed free-flaps, preclinical tissular engineering studies have been developed. Total bone marrow (TBM) associated with biphasic calcium phosphate (BCP) significantly enhanced bone formation in irradiated bone. One mechanism, explaining how bone marrow cells can help regenerate tissues like this, is the paracrine effect...
2017: PloS One
https://www.readbyqxmd.com/read/28489628/lengthening-of-newly-formed-humerus-after-autologous-fibula-graft-transplantation-following-intercalary-tumor-resection
#17
Hakan Pilge, Martin Ruppert, Bernd Bittersohl, Bettina Westhoff, Rüdiger Krauspe
Secondary limb lengthening after intercalary bone resection in pediatric patients is still challenging. After the resection, a free fibula autograft can be used to reconstruct the osseous gap. However, in particular in young pediatric patients, insufficient growth of the epiphyseal plate after transplantation may lead to a significant limb-length discrepancy (LLD). In this case, the autograft was used for limb lengthening. We report on the lengthening of a humerus regenerate after fibula autograft transplantation into a humeral defect in a pediatric/young adolescent patient...
May 5, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28462179/use-of-platelet-rich-plasma-in-the-management-of-periodontal-intra-osseous-defects-a-clinical-study
#18
Md Jalaluddin, Dhirendra K Singh, Ipsita Jayanti, Prasad Kulkarni, Mohamed Faizuddin, Fouzia Tarannum
BACKGROUND: Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment, and alveolar bone around the affected tooth. Alveolar bone support and attachment apparatus regeneration has been achieved through various processes and have given elusive results. An expedient and cost-effective approach to obtain autologous platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β is the use of platelet-rich plasma (PRP)...
March 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28421969/dystrophic-mineralization-of-costal-cartilage-in-hartley-guinea-pigs
#19
Alexandria M Schauer, Adrienne Schucker, Cathy S Carlson
Hartley guinea pigs are widely used animal models of disease, particularly in studies of osteoarthritis. The purpose of this study was to investigate lesions in the costal cartilage from 16 male, 5- to 6-month-old Hartley guinea pigs. Routine histological sections from the costal cartilage and costochondral junction (longitudinal and cross sections) and sternum (for evaluation of bone marrow) were examined. All 16 (100%) animals had histological lesions involving the costal cartilage that included matrix degeneration and mineralization, reduced cellularity, and evidence of chondrocyte necrosis...
April 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28415545/engineering-bone-regeneration-with-novel-cell-laden-hydrogel-microfiber-injectable-calcium-phosphate-scaffold
#20
Yang Song, Chi Zhang, Ping Wang, Lin Wang, Chunyun Bao, Michael D Weir, Mark A Reynolds, Ke Ren, Liang Zhao, Hockin H K Xu
Cell-based tissue engineering is promising to create living functional tissues for bone regeneration. The implanted cells should be evenly distributed in the scaffold, be fast-released to the defect and maintain high viability in order to actively participate in the regenerative process. Herein, we report an injectable calcium phosphate cement (CPC) scaffold containing cell-encapsulating hydrogel microfibers with desirable degradability that could deliver cells in a timely manner and maintain cell viability...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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