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https://www.readbyqxmd.com/read/29303409/clinical-evaluation-of-a-new-synthetic-resorbable-dental-membrane-a-case-series-study
#1
Hélène Martin Thomé, David Bourdin, Nicolas Strube, Afchine Saffarzadeh, Jean-Francois Morlock, Guillaume Campard, Charles Evanno, Alain Hoornaert, Pierre Layrolle
For the regeneration of small osseous defects, dental membranes are commonly used in oral and maxillofacial surgery. A new synthetic resorbable membrane has recently demonstrated its biocompatibility and bone regeneration capacity in preclinical studies. This membrane is made of poly-D,L-lactic/glycolic acid 85/15 (PLGA), has a bi-layered structure with a dense film to prevent gingival epithelial cell invasion and a micro-fibrous layer to support osteogenic cells and bone healing. This membrane completely degrades by hydrolysis in 4 to 6 months without signs of inflammation...
January 5, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29286432/in-vivo-evaluation-of-fracture-callus-development-during-bone-healing-in-mice-using-an-mri-compatible-osteosynthesis-device-for-the-mouse-femur
#2
Melanie Haffner-Luntzer, Fabian Müller-Graf, Romano Matthys, Alireza Abaei, René Jonas, Florian Gebhard, Volker Rasche, Anita Ignatius
Endochondral fracture healing is a complex process involving the development of fibrous, cartilaginous, and osseous tissue in the fracture callus. The amount of the different tissues in the callus provides important information on the fracture healing progress. Available in vivo techniques to longitudinally monitor the callus tissue development in preclinical fracture-healing studies using small animals include digital radiography and µCT imaging. However, both techniques are only able to distinguish between mineralized and non-mineralized tissue...
November 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29249017/teriparatide-therapy-for-severe-refractory-osteoradionecrosis-of-the-jaw
#3
Y H Cha, N Hong, Y Rhee, I-H Cha
Although osteoradionecrosis (ORN) is a serious complication of craniofacial radiotherapy, the current management methods remain suboptimal. Teriparatide (TPTD), a recombinant human parathyroid hormone (1-34), has shown beneficial effects on osseous regeneration in medication-related osteonecrosis of the jaw or periodontitis. However, TPTD therapy in irradiated bones has not been indicated yet because of the theoretical risk of osteosarcoma seen in rat models. Hence, we first report here two patients with tongue cancer with late-emerging ORN who were successfully treated with TPTD for 4-6 months with serum calcium and vitamin D supplementation...
December 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29243352/a-review-on-gradient-hydrogel-fiber-scaffolds-for-osteochondral-regeneration
#4
REVIEW
Sajedeh Khorshidi, Akbar Karkhaneh
Osteochondral tissue regeneration is a complicated field due to the distinct properties and healing potential of osseous and chondral phases. In a natural osteochondral region, the composition, mechanics and structure vary smoothly from bony to cartilaginous phase. Therefore, a homogeneous scaffold cannot satisfy the complexity of the osteochondral matrix. In essence, a natural extracellular matrix (ECM) is composed of fibrous proteins elongated into a gelatinous background. A hydrogel/fiber scaffold possessing gradient in both phases would be of the utmost interest to imitate tissue arrangement of a native osteochondral interface...
December 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29229078/management-of-peri-implantitis-a-contemporary-synopsis
#5
REVIEW
Wendy Cw Wang, Miltiadis Lagoudis, Che-Wei Yeh, Klenise S Paranhos
Prevalence of peri-implant complication is expected to be on the rise with the increased number of implants being placed. Depending on the degree of osseous involvement, the clinician needs to decide if the treatment goal is to arrest the disease progression, regeneration or explantation and replacement. Host's medical status, defect configuration, aesthetic outcome, ability to access for plaque control post-treatment, and the patient's wishes are key factors to consider. The purpose of this review is to provide a contemporary synopsis on the management of peri-implantitis with emphasis on explantation...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29225159/histopathology-of-periarticular-non-hereditary-heterotopic-ossification
#6
REVIEW
Kristin L Foley, Nader Hebela, Mary Ann Keenan, Robert J Pignolo
In the mature adult skeleton, new bone formation is normally restricted to regeneration of osseous tissue at sites of fracture. However, heterotopic ossification, or the formation of bone outside the normal skeleton, can occur within muscle, adipose, or fibrous connective tissue. Periarticular non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, following CNS injury, with certain arthropathies, or following injury or surgery that is often sustained in the context of age-related pathology...
December 7, 2017: Bone
https://www.readbyqxmd.com/read/29186078/biological-properties-of-low-toxicity-plga-and-plga-phb-fibrous-nanocomposite-implants-for-osseous-tissue-regeneration-part-i-evaluation-of-potential-biotoxicity
#7
Izabella Krucińska, Bogusława Żywicka, Agnieszka Komisarczyk, Maria Szymonowicz, Stanisława Kowalska, Ewa Zaczyńska, Marcin Struszczyk, Anna Czarny, Piotr Jadczyk, Barbara Umińska-Wasiluk, Zbigniew Rybak, Marek Kowalczuk
In response to the demand for new implant materials characterized by high biocompatibility and bioresorption, two prototypes of fibrous nanocomposite implants for osseous tissue regeneration made of a newly developed blend of poly(l-lactide-co-glycolide) (PLGA) and syntheticpoly([R,S]-3-hydroxybutyrate), PLGA/PHB, have been developed and fabricated. Afibre-forming copolymer of glycolide and l-lactide (PLGA) was obtained by a unique method of synthesis carried out in blocksusing Zr(AcAc)₄ as an initiator. The prototypes of the implants are composed of three layers of PLGA or PLGA/PHB, nonwoven fabrics with a pore structure designed to provide the best conditions for the cell proliferation...
November 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29147489/the-effect-of-platelet-rich-plasma-on-human-mesenchymal-stem-cell-induced-bone-regeneration-of-canine-alveolar-defects-with-calcium-phosphate-based-scaffolds
#8
Reihaneh Shafieian, Maryam Moghaddam Matin, Amin Rahpeyma, Alireza Fazel, Hamideh Salari Sedigh, Ariane Sadr-Nabavi, Halimeh Hassanzadeh, Alireza Ebrahimzadeh-Bideskan
Objectives: Autologous bone transplantation known as the "gold standard" to reconstruction of osseous defects has known disadvantages. This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. Materials and Methods: hAdMSCs were incubated with HA/TCP granules and/or PRP in vitro and then, cell proliferation and differentiation was assessed by MTT assay, AZR S staining and SEM examination...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29143781/biological-properties-of-low-toxic-plga-and-plga-phb-fibrous-nanocomposite-scaffolds-for-osseous-tissue-regeneration-evaluation-of-potential-bioactivity
#9
Boguslawa Żywicka, Izabella Krucińska, Jerzy Garcarek, Maria Szymonowicz, Agnieszka Komisarczyk, Zbigniew Rybak
Abstracts: The aim of the study was to evaluate the biocompatibility and bioactivity of two new prototype implants for bone tissue regeneration made from biodegradable fibrous materials. The first is a newly developed poly(l-lactide-co-glycolide), (PLGA), and the second is a blend of PLGA with synthetic poly([R,S]-3-hydroxybutyrate) (PLGA/PHB). The implant prototypes comprise PLGA or PLGA/PHB nonwoven fabrics with designed pore structures to create the best conditions for cell proliferation. The bioactivity of the proposed implants was enhanced by introducing a hydroxyapatite material and a biologically active agent, namely, growth factor IGF1, encapsulated in calcium alginate microspheres...
October 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29123550/mesenchymal-stem-cells-for-cartilage-regeneration-of-tmj-osteoarthritis
#10
REVIEW
Dixin Cui, Hongyu Li, Xin Xu, Ling Ye, Xuedong Zhou, Liwei Zheng, Yachuan Zhou
Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29107477/contribution-of-implanted-genetically-modified-muscle-progenitor-cells-expressing-bmp-2-to-new-bone-formation-in-a-rat-osseous-defect
#11
Rodolfo E De La Vega, Consuelo Lopez De Padilla, Miguel Trujillo, Nicholas Quirk, Ryan M Porter, Christopher H Evans, Elisabeth Ferreira
Because muscle contains osteoprogenitor cells and has a propensity to form bone, we have explored its utility in healing large osseous defects. Healing is achieved by the insertion of muscle fragments transduced with adenovirus encoding BMP-2 (Ad.BMP-2). However, it is not known whether the genetically modified muscle contributes osteoprogenitor cells to healing defects or merely serves as a local source of BMP-2. This question is part of the larger debate on the fate of progenitor cells introduced into sites of tissue damage to promote regeneration...
October 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29063586/protein-expression-during-early-stages-of-bone-regeneration-under-hydrophobic-and-hydrophilic-titanium-domes-a-pilot-study
#12
E Calciolari, N Mardas, X Dereka, A K Anagnostopoulos, G T Tsangaris, N Donos
BACKGROUND AND OBJECTIVES: There is significant evidence that, during the early stages of osseointegration, moderately rough hydrophilic (SLActive) surfaces can accelerate osteogenesis and increase bone-to-implant contact in comparison to hydrophobic (SLA) surfaces. However, very little is known regarding the molecular mechanisms behind the influence that surface chemistry modifications to increase hydrophilicity determine on bone healing. The aim of this study was to describe for the first time the proteins and related signalling pathways expressed during early osseous healing stages under SLA and SLActive titanium domes for guided bone regeneration...
October 24, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29025250/ceramic-polylactide-composite-material-used-in-a-model-of-healing-of-osseous-defects-in-rabbits
#13
Paweł Myciński, Joanna Zarzecka, Agnieszka Skórska-Stania, Agnieszka Jelonek, Krzysztof Okoń, Maria Wróbel
The growing demand for various kinds of bone regeneration material has in turn increased the desire to find materials with optimal physical, chemical, and biological properties. The objective of the present study was to identify the proportions of ceramic and polylactide components in a bone substitute material prepared in collaboration with the Crystal Chemistry of Drugs Team of the Faculty of Chemistry at the Jagiellonian University, which would be optimal for bone regeneration processes. Another goal was to provide a histological analysis of the influence of a ceramic-polylactide composite on the healing of osseous defects in rabbits...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/28992803/collagen-sponge-functionalized-with-chimeric-anti-bmp-2-monoclonal-antibody-mediates-repair-of-nonunion-tibia-defects-in-a-nonhuman-primate-model-an-exploratory-study
#14
Lijia Guo, Seiko Min, Yingying Su, Jianxia Tang, Juan Du, Bee Tin Goh, Leonardo Saigo, Songlin Wang, Sahar Ansari, Alireza Moshaverinia, Homayoun H Zadeh, Yi Liu
Recombinant human bone morphogenetic protein (BMP)-2 is an FDA-approved therapy for nonunion tibia fracture, though it has a number of biological and practical disadvantages. Our research group has developed a novel tissue engineering strategy termed antibody-mediated osseous regeneration. This entails application of anti-BMP-2 monoclonal antibodies (mAbs) to capture endogenous BMP's to mediate in vivo bone formation. This has been documented in a number of animal models. The present exploratory study sought to investigate the application of antibody-mediated osseous regeneration for repair of nonunion tibia defect in a nonhuman primate model...
October 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28982588/low-1-level-mechanical-vibration-improves-bone-microstructure-tissue-mechanical-properties-and-porous-titanium-implant-osseointegration-by-promoting-anabolic-response-in-type-1-diabetic-rabbits
#15
Da Jing, Zedong Yan, Jing Cai, Shichao Tong, Xiaokang Li, Zheng Guo, Erping Luo
Type 1 diabetes mellitus (T1DM) is associated with reduced bone mass, increased fracture risk, and impaired bone defect regeneration potential. These skeletal complications are becoming important clinical challenges due to the rapidly increasing T1DM population, which necessitates developing effective treatment for T1DM-associated osteopenia/osteoporosis and bone trauma. This study aims to investigate the effects of whole-body vibration (WBV), an easy and non-invasive biophysical method, on bone microstructure, tissue-level mechanical properties and porous titanium (pTi) osseointegration in alloxan-diabetic rabbits...
October 2, 2017: Bone
https://www.readbyqxmd.com/read/28951742/guided-bone-regeneration-using-collagen-scaffolds-growth-factors-and-periodontal-ligament-stem-cells-for-treatment-of-peri-implant-bone-defects-in-vivo
#16
Peer W Kämmerer, Malte Scholz, Maria Baudisch, Jan Liese, Katharina Wegner, Bernhard Frerich, Hermann Lang
INTRODUCTION: The aim of the study was an evaluation of different approaches for guided bone regeneration (GBR) of peri-implant defects in an in vivo animal model. MATERIALS AND METHODS: In minipigs (n = 15), peri-implant defects around calcium phosphate- (CaP-; n = 46) coated implants were created and randomly filled with (1) blank, (2) collagen/hydroxylapatite/β-tricalcium phosphate scaffold (CHT), (3) CHT + growth factor cocktail (GFC), (4) jellyfish collagen matrix, (5) jellyfish collagen matrix + GFC, (6) collagen powder, and (7) collagen powder + periodontal ligament stem cells (PDLSC)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28893033/comparative-evaluation-of-bioactive-glass-putty-and-platelet-rich-fibrin-in-the-treatment-of-human-periodontal-intrabony-defects-a-randomized-control-trial
#17
Akbar Naqvi, D Gopalakrishnan, Meenu Taneja Bhasin, Nilima Sharma, Khushtar Haider, Santosh Martande
INTRODUCTION: Platelet-Rich Fibrin (PRF) and bioactive glass putty have been shown to be effective in promoting reduction in probing depth, gain in clinical attachment, and defect fill in intrabony periodontal defects. The individual role played by bioactive glass putty in combination with PRF is yet to be elucidated. AIM: To compare the clinical effectiveness of the combination of PRF and bioactive glass putty and bioactive glass putty alone as regenerative techniques for intrabony defects in humans...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28875278/investigation-of-peri-implant-tissue-conditions-and-peri-implant-tissue-stability-in-implants-placed-with-simultaneous-augmentation-procedure-a-3-year-retrospective-follow-up-analysis-of-a-newly-developed-bone-level-implant-system
#18
Jonas Lorenz, Henriette Lerner, Robert A Sader, Shahram Ghanaati
BACKGROUND: Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. The aim of the present retrospective analysis was to assess peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure. METHODS: A total of 47 implants, which were placed simultaneously with a GBR procedure with a synthetic bone substitute material in 20 patients, were investigated clinically and radiologically at least 3 years after loading...
September 5, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28863592/numerical-evaluation-of-the-backward-propagating-acoustic-field-in-healing-long-bones
#19
Vassiliki T Potsika, Vasilios C Protopappas, Konstantinos N Grivas, Theodoros V Gortsas, Kay Raum, Demosthenes K Polyzos, Dimitrios I Fotiadis
The propagation of ultrasound in healing long bones induces complex scattering phenomena due to the interaction of an ultrasonic wave with the composite nature of callus and osseous tissues. This work presents numerical simulations of ultrasonic propagation in healing long bones using the boundary element method aiming to provide insight into the complex scattering mechanisms and better comprehend the state of bone regeneration. Numerical models of healing long bones are established based on scanning acoustic microscopy images from successive postoperative weeks considering the effect of the nonhomogeneous callus structure...
August 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28844964/regenerating-bone-with-bioactive-glass-scaffolds-a-review-of-in-vivo-studies-in-bone-defect-models
#20
REVIEW
Aiah A El-Rashidy, Judith A Roether, Leila Harhaus, Ulrich Kneser, Aldo R Boccaccini
Large bone defects resulting from fractures and disease are a medical concern, being often unable to heal spontaneously by the body's repair mechanisms. Bone tissue engineering (BTE) is a promising approach for treating bone defects through providing a template to guide osseous regeneration. 3D scaffolds with microstructure mimicking host bone are necessary in common BTE strategies. Bioactive glasses (BGs) attract researchers' attention as BTE scaffolds as they are osteoconductive and osteoinductive in certain formulations...
August 24, 2017: Acta Biomaterialia
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