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https://www.readbyqxmd.com/read/28629025/polycaprolactone-and-polycaprolactone-ceramic-based-3d-bioplotted-porous-scaffolds-for-bone-regeneration-a-comparative-study
#1
K K Gómez-Lizárraga, C Flores-Morales, M L Del Prado-Audelo, M A Álvarez-Pérez, M C Piña-Barba, C Escobedo
One of the critical challenges that scaffolding faces in the organ and tissue regeneration field lies in mimicking the structure, and the chemical and biological properties of natural tissue. A high-level control over the architecture, mechanical properties and composition of the materials in contact with cells is essential to overcome such challenge. Therefore, definition of the method, materials and parameters for the production of scaffolds during the fabrication stage is critical. With the recent emergence of rapid prototyping (RP), it is now possible to create three-dimensional (3D) scaffolds with the essential characteristics for the proliferation and regeneration of tissues, such as porosity, mechanical strength, pore size and pore interconnectivity, and biocompatibility...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28581710/biotransformation-of-silver-released-from-nanoparticle-coated-titanium-implants-revealed-in-regenerating-bone
#2
Hua Geng, Gowsihan Poologasundarampillai, Naomi Todd, Aine Devlin-Mullin, Katie L Moore, Zahra Golrokhi, James B Gilchrist, Eric Jones, Richard J Potter, Chris Sutcliffe, Marie O'Brien, David W L Hukins, Sarah Cartmell, Christopher A Mitchell, Peter D Lee
Antimicrobial silver nanoparticle coatings have attracted interest for reducing prosthetic joint infection. However, few studies report in vivo investigations of the biotransformation of silver nanoparticles within the regenerating tissue and its impact on bone formation. We present a longitudinal investigation of the osseointegration of silver nanoparticle-coated additive manufactured titanium implants in rat tibial defects. Correlative imaging at different time points using nanoscale secondary ion mass spectrometry, transmission electron microscopy (TEM), histomorphometry, and 3D X-ray microcomputed tomography provided quantitative insight from the nano- to macroscales...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28542343/bone-marrow-cell-extract-promotes-the-regeneration-of-irradiated-bone
#3
Guillaume Michel, Pauline Blery, Michaël Henoux, Jérôme Guicheux, Pierre Weiss, Sophie Brouard, Olivier Malard, Florent Espitalier
Mandibular osteoradionecrosis is a severe side effect of radiotherapy after the treatment of squamous cell carcinomas of the upper aerodigestive tract. As an alternative to its treatment by micro-anastomosed free-flaps, preclinical tissular engineering studies have been developed. Total bone marrow (TBM) associated with biphasic calcium phosphate (BCP) significantly enhanced bone formation in irradiated bone. One mechanism, explaining how bone marrow cells can help regenerate tissues like this, is the paracrine effect...
2017: PloS One
https://www.readbyqxmd.com/read/28489628/lengthening-of-newly-formed-humerus-after-autologous-fibula-graft-transplantation-following-intercalary-tumor-resection
#4
Hakan Pilge, Martin Ruppert, Bernd Bittersohl, Bettina Westhoff, Rüdiger Krauspe
Secondary limb lengthening after intercalary bone resection in pediatric patients is still challenging. After the resection, a free fibula autograft can be used to reconstruct the osseous gap. However, in particular in young pediatric patients, insufficient growth of the epiphyseal plate after transplantation may lead to a significant limb-length discrepancy (LLD). In this case, the autograft was used for limb lengthening. We report on the lengthening of a humerus regenerate after fibula autograft transplantation into a humeral defect in a pediatric/young adolescent patient...
May 5, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28462179/use-of-platelet-rich-plasma-in-the-management-of-periodontal-intra-osseous-defects-a-clinical-study
#5
Md Jalaluddin, Dhirendra K Singh, Ipsita Jayanti, Prasad Kulkarni, Mohamed Faizuddin, Fouzia Tarannum
BACKGROUND: Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment, and alveolar bone around the affected tooth. Alveolar bone support and attachment apparatus regeneration has been achieved through various processes and have given elusive results. An expedient and cost-effective approach to obtain autologous platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β is the use of platelet-rich plasma (PRP)...
March 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28421969/dystrophic-mineralization-of-costal-cartilage-in-hartley-guinea-pigs
#6
Alexandria M Schauer, Adrienne Schucker, Cathy S Carlson
Hartley guinea pigs are widely used animal models of disease, particularly in studies of osteoarthritis. The purpose of this study was to investigate lesions in the costal cartilage from 16 male, 5- to 6-month-old Hartley guinea pigs. Routine histological sections from the costal cartilage and costochondral junction (longitudinal and cross sections) and sternum (for evaluation of bone marrow) were examined. All 16 (100%) animals had histological lesions involving the costal cartilage that included matrix degeneration and mineralization, reduced cellularity, and evidence of chondrocyte necrosis...
April 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28415545/engineering-bone-regeneration-with-novel-cell-laden-hydrogel-microfiber-injectable-calcium-phosphate-scaffold
#7
Yang Song, Chi Zhang, Ping Wang, Lin Wang, Chunyun Bao, Michael D Weir, Mark A Reynolds, Ke Ren, Liang Zhao, Hockin H K Xu
Cell-based tissue engineering is promising to create living functional tissues for bone regeneration. The implanted cells should be evenly distributed in the scaffold, be fast-released to the defect and maintain high viability in order to actively participate in the regenerative process. Herein, we report an injectable calcium phosphate cement (CPC) scaffold containing cell-encapsulating hydrogel microfibers with desirable degradability that could deliver cells in a timely manner and maintain cell viability...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28401163/collagen-sponge-functionalized-with-chimeric-anti-bmp-2-monoclonal-antibody-mediates-repair-of-critical-size-mandibular-continuity-defects-in-a-nonhuman-primate-model
#8
Yilin Xie, Yingying Su, Seiko Min, Jianxia Tang, Bee Tin Goh, Leonardo Saigo, Sahar Ansari, Alireza Moshaverinia, Chunmei Zhang, Jinsong Wang, Yi Liu, Arash Khojasteh, Homayoun H Zadeh, Songlin Wang
Antibody-mediated osseous regeneration (AMOR) has been introduced by our research group as a tissue engineering approach to capture of endogenous growth factors through the application of specific monoclonal antibodies (mAbs) immobilized on a scaffold. Specifically, anti-Bone Morphogenetic Protein- (BMP-) 2 mAbs have been demonstrated to be efficacious in mediating bone repair in a number of bone defects. The present study sought to investigate the application of AMOR for repair of mandibular continuity defect in nonhuman primates...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28363521/effectiveness-of-tissue-engineered-chitosan-gelatin-composite-scaffold-loaded-with-human-platelet-gel-in-regeneration-of-critical-sized-radial-bone-defect-in-rat
#9
Ahmad Oryan, Soodeh Alidadi, Amin Bigham-Sadegh, Ali Moshiri, Amir Kamali
Although many strategies have been utilized to accelerate bone regeneration, an appropriate treatment strategy to regenerate a new bone with optimum morphology and mechanical properties has not been invented as yet. This study investigated the healing potential of a composite scaffold consisting of chitosan (CS), gelatin (Gel) and platelet gel (PG), named CS-Gel-PG, on a bilateral critical sized radial bone defect in rat. Eighty radial bone defects were bilaterally created in 40 Sprague-Dawley rats and were randomly divided into eight groups including untreated, autograft, CS, Gel, CS-PG, Gel-PG, CS-Gel, and CS-Gel-PG treated defects...
March 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28298823/clinical-efficacy-of-subgingivally-delivered-simvastatin-gel-in-chronic-periodontitis-patients
#10
Swati Agarwal, Krishna Kumar Chaubey, Abhinav Chaubey, Vikas Agarwal, Ellora Madan, Manvi Chandra Agarwal
BACKGROUND: Simvastatin (SMV), a new locally delivered drug of class statins, is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Statins, besides having lipid-lowering abilities, also have pleiotropic effects like host modulation and bone regeneration. The present study was designed to investigate the effectiveness of SMV, 1.2 mg, in an indigenously prepared biodegradable controlled-release gel as an adjunct to scaling and root planing (SRP). MATERIALS AND METHODS: A total of 60 sites, with pocket depth ≥5 mm, two from each of 30 patients after SRP, were categorized into two treatment groups, for subgingival placement of placebo (Gp 1) or SMV (Gp 2)...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28286396/reconstruction-of-a-post-traumatic-anterior-maxillary-defect-by-transport-distraction-osteogenesis
#11
K Rajkumar, R S Neelakandan, Pradeep Devadoss, T K Bandyopadhyay
Rehabilitation of segmental defects of maxilla presents a reconstructive challenge to obtain an ideal osseous form and height with adequate soft tissue investment. Though variety of prosthetic and surgical reconstructive options like the use of vascularized and non vascularized bone grafts are available they produce less than optimal results. Bone transport distraction is a reliable procedure in various maxillofacial bony defect reconstruction techniques. We describe herein a technique of maxillary bone transport distraction using an indigenously designed, custom made trifocal transport distractor performed in a post traumatic avulsive defect of the anterior maxilla...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28286388/autogenous-bone-marrow-aspirate-coated-synthetic-hydroxyapatite-for-reconstruction-of-maxillo-mandibular-osseous-defects-a-prospective-study
#12
Raja Sekhar Gali, Sathya Kumar Devireddy, N Mohan Rao, R V Kishore Kumar, Sridhar Reddy Kanubaddy, Mallikarjuna Dasari, K Sowjanya, Rama Mohan Pathapati
PURPOSE: This prospective study was conducted to evaluate the bone regeneration capacity of synthetic hydroxyapatite mixed with autogenous bone marrow aspirate when used as a bone graft substitute in maxillo-mandibular osseous defects. METHODS: This study included nine patients with histopathalogically proven benign osteolytic lesions in maxilla and mandible that were treated with enucleation or marginal resection followed by bone marrow aspirate coated synthetic biphasic hydroxyapatite (hydroxyapatite and beta tricalcium phosphate) graft placement...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28274048/evaluation-of-cyclosporine-a-with-%C3%AE-tcp-in-the-treatment-of-human-infra-bony-defects-a-randomized-controlled-pilot-study
#13
Jyotsna Amalakara, Krishnajaneya Reddy, Haritha Avula, Ashank Mishra, Butchibabu Kalakonda, Ruchi Pandey
INTRODUCTION: Cyclosporine A (CsA), an immunosuppressant, is considered a life saver drug in organ transplant cases. It has also been tested in animal and human studies for periodontal applications as it selectively inhibits T lymphocyte proliferation, Interleukin-2 (IL-2) and other cytokine production, without any effect on T suppressor cells, thereby suppressing the cell mediated immunity and suppressing the inflammation. Inflammatory and immunological responses have been found to be decreased and bone formation is found to be increased in immunosuppressed animals...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28249808/potential-for-osseous-regeneration-of-platelet-rich-fibrin-a-comparative-study-in-mandibular-third-molar-impaction-sockets
#14
Mathew P Varghese, Suvy Manuel, Surej Kumar L K
PURPOSE: This study investigated the potential of platelet-rich fibrin (PRF) for osseous regeneration and soft tissue healing in mandibular third molar impaction sockets. MATERIALS AND METHODS: A prospective in vivo study was performed. Randomization was performed after extraction. On one side, the socket was sutured primarily (control site); on the other side, autologous PRF gel was placed and then the socket was sutured (test site). Postoperatively, grid periapical radiographs were obtained at periodic intervals (weeks 1, 4, and 16) and digitalized...
February 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28199140/role-of-bone-marrow-stromal-cells-in-impaired-bone-repair-from-bronj-osseous-lesions
#15
L H He, E Xiao, J G An, Y He, S Chen, L Zhao, T Zhang, Y Zhang
Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed significant challenges to maxillofacial surgeons because of the poor repair of BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone marrow stromal cells (BMSCs) play key roles during bone repair and bone regeneration. However, the activities of BMSCs derived from BRONJ lesions and the BRONJ lesion boundary, as well as the roles of BMSCs in BRONJ defect repair, are poorly defined. In this study, we found that BMSCs from the central area of the osteonecrotic BRONJ region (center-BRONJ BMSCs) and the peripheral area at the recommended debridement boundary (peri-BRONJ BMSCs) had decreased proliferative ability, self-renewal capacity, and multidifferentiation capacities compared with control BMSCs...
May 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28127157/comparative-evaluation-of-bioactive-synthetic-novabone-putty-and-calcified-algae-derived-porous-hydroxyapatite-bone-grafts-for-the-treatment-of-intrabony-defects
#16
Nitika N Bembi, Sumit Bembi, Jyoti Mago, Gurpreet Kaur Baweja, Parvinder Singh Baweja
INTRODUCTION: To compare and evaluate clinically and radio-graphically the bone regeneration and the amount of bone fill in intrabony component of periodontal osseous defects through the osteoconductive and osteostimulative effect of bioactive synthetic NovaBone Putty - CMF and osteoconductive effect of calcified algae-derived porous hydroxyapatite Frios(®) Algi-pore(®) bone grafts. MATERIALS AND METHODS: Twenty-two sites in 11 patients, within the age range of 25 to 60 years, showing intrabony defects were selected according to split mouth design and divided into group I (Frios(®) Algipore(®)) and group II (NovaBone Putty - CMF)...
October 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28096214/cartilage-to-bone-transformation-during-fracture-healing-is-coordinated-by-the-invading-vasculature-and-induction-of-the-core-pluripotency-genes
#17
Diane P Hu, Federico Ferro, Frank Yang, Aaron J Taylor, Wenhan Chang, Theodore Miclau, Ralph S Marcucio, Chelsea S Bahney
Fractures heal predominantly through the process of endochondral ossification. The classic model of endochondral ossification holds that chondrocytes mature to hypertrophy, undergo apoptosis and new bone forms by invading osteoprogenitors. However, recent data demonstrate that chondrocytes transdifferentiate to osteoblasts in the growth plate and during regeneration, yet the mechanism(s) regulating this process remain unknown. Here, we show a spatially-dependent phenotypic overlap between hypertrophic chondrocytes and osteoblasts at the chondro-osseous border in the fracture callus, in a region we define as the transition zone (TZ)...
January 15, 2017: Development
https://www.readbyqxmd.com/read/28070691/biological-characteristic-effects-of-human-dental-pulp-stem-cells-on-poly-%C3%AE%C2%B5-caprolactone-biphasic-calcium-phosphate-fabricated-scaffolds-using-modified-melt-stretching-and-multilayer-deposition
#18
Natkrita Wongsupa, Thongchai Nuntanaranont, Suttatip Kamolmattayakul, Nuttawut Thuaksuban
Craniofacial bone defects such as alveolar cleft affect the esthetics and functions that need bone reconstruction. The advanced techniques of biomaterials combined with stem cells have been a challenging role for maxillofacial surgeons and scientists. PCL-coated biphasic calcium phosphate (PCL-BCP) scaffolds were created with the modified melt stretching and multilayer deposition (mMSMD) technique and merged with human dental pulp stem cells (hDPSCs) to fulfill the component of tissue engineering for bone substitution...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28068758/strontium-doped-amorphous-calcium-phosphate-porous-microspheres-synthesized-through-a-microwave-hydrothermal-method-using-fructose-1-6-bisphosphate-as-an-organic-phosphorus-source-application-in-drug-delivery-and-enhanced-bone-regeneration
#19
Weilin Yu, Tuan-Wei Sun, Chao Qi, Zhenyu Ding, Huakun Zhao, Feng Chen, Daoyun Chen, Ying-Jie Zhu, Zhongmin Shi, Yaohua He
Nanostructured calcium phosphate porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility, and similarity to inorganic component of osseous tissue. In this work, strontium (Sr)-doped amorphous calcium phosphate porous microspheres (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt as the source of phosphate ions. The SrAPMs showed a mesoporous structure and a relatively high specific area...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28054585/osseous-differentiation-of-human-fat-tissue-grafts-from-tissue-engineering-to-tissue-differentiation
#20
Maryna Bondarava, Chiara Cattaneo, Bin Ren, Wolfgang E Thasler, Volkmar Jansson, Peter E Müller, Oliver B Betz
Conventional bone tissue engineering approaches require isolation and in vitro propagation of autologous cells, followed by seeding on a variety of scaffolds. Those protracted procedures impede the clinical applications. Here we report the transdifferentiation of human fat tissue fragments retrieved from subcutaneous fat into tissue with bone characteristics in vitro without prior cell isolation and propagation. 3D collagen-I cultures of human fat tissue were cultivated either in growth medium or in osteogenic medium (OM) with or without addition of Bone Morphogenetic Proteins (BMPs) BMP-2, BMP-7 or BMP-9...
January 5, 2017: Scientific Reports
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