keyword
https://read.qxmd.com/read/38088179/revision-of-failed-nonanatomic-extensor-retinacular-stabilization-of-the-unstable-ecu-tendon-surgical-technique-and-case-series
#21
JOURNAL ARTICLE
Stuart W Jones, Fiona C Campbell, Douglas A Campbell
Nonanatomic surgical stabilization of the unstable extensor carpi ulnaris (ECU) tendon (where the subluxing tendon is re-routed away from the bony groove in the distal ulna) utilizes a flap of extensor retinaculum to create a new retaining sheath that will stabilize the tendon during forearm rotation movements. When this surgery fails, the extensor retinaculum tissue does not regenerate with sufficient structural strength to be used again. Previously, a different approach has then been needed for revision surgery, often using more complex surgical techniques with a substantially greater impact on recovery...
December 13, 2023: Techniques in Hand & Upper Extremity Surgery
https://read.qxmd.com/read/38085979/the-use-of-resorbable-fixation-for-posterior-cranial-vault-distraction-osteogenesis
#22
JOURNAL ARTICLE
Daniel Y Cho, Jessica D Blum, Dillan F Villavisanis, Jinggang J Ng, Jordan Swanson, Scott P Bartlett, Jesse A Taylor
Posterior vault distraction osteogenesis (PVDO) traditionally relies on the use of cranial distractors affixed with titanium screws to the posterior cranial vault transport segment to allow for expansion of intracranial volume. We describe a novel technique using the Synthes RAPIDSORB IPS resorbable fixation system for stable fixation of the distraction hardware for PVDO. In a retrospective review of our experience with the IPS system, there was no instance of hardware or fixation failure. This off-label use of the IPS system results in a significant reduction in operative time for hardware removal while allowing for a more limited dissection, which can help reduce devascularization of the bony regenerate, bony relapse, and other complications...
December 5, 2023: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38085751/comparative-histomorphometric-analysis-of-bone-regeneration-according-to-bone-graft-type
#23
JOURNAL ARTICLE
Hwa Suk Chae, Hyunsuk Choi, Insook Park, Yong-Suk Moon, Dong-Seok Sohn
PURPOSE: To use histomorphometric analysis to evaluate bone reconstruction in rabbit calvaria with autogenous bone, anorganic bovine bone, undecalcified human tooth bone (UdTB), and decalcified human tooth bone (dTB) grafts. MATERIALS AND METHODS: Extracted human teeth were crushed, and tooth bone with and without decalcification was prepared. Bony defects were made in 10 rabbit calvaria and allocated to one of the following four groups: group 1, in which UdTB was grafted; group 2, in which dTB was grafted; group 3, in which anorganic bovine bone was grafted; group 4, in which autogenous bone was grafted...
December 12, 2023: International Journal of Oral & Maxillofacial Implants
https://read.qxmd.com/read/38077229/role-of-individual-and-combined-impact-of-simvastatin-and-%C3%AE-tcp-in-rat-calvarial-bone-defect-an-experimental-study
#24
JOURNAL ARTICLE
Surendar Sugumaran, Deepak Selvam, M S Nivedhitha, Karthik Ganesh Mohanraj, Bader O Almutairi, Selvaraj Arokiyaraj, Ajay Guru, Jesu Arockiaraj
BACKGROUND: Bone substitutes have been used by doctors for a long time to treat osseous abnormalities. Recently, scientists have been searching for suitable materials to replace bone. Autogenous bone grafts are considered the gold standard for osseous regeneration. However, the limited availability of intraoral sources for grafting material often requires the use of secondary donor sites. AIM: This study aims to compare a control group of standard critical bone defect models treated without any bone transplants to critical size calvarial bony defects treated with various bone replacements, including simvastatin and α-tricalcium phosphate, while analyzing the healing patterns...
November 2023: Saudi Dental Journal
https://read.qxmd.com/read/38044459/a-novel-periodontal-endoscopy-aided-non-incisional-periodontal-regeneration-technique-in-the-treatment-of-intrabony-defects-a-retrospective-cohort-study
#25
JOURNAL ARTICLE
Jiahong Shi, Jinmeng Wang, Zhiyu Yang, Jingwen Li, Lang Lei, Houxuan Li
BACKGROUND: Gingival recession and post-operation discomfort are still a problem for patients receiving the periodontal regeneration surgery for intra-bony defects. To further reduce the trauma and the post-operation gingival recession, a novel periodontal endoscopy-aided non-incisional regeneration technique (NIT) was proposed in the treatment of intra-bony defects. METHODS: Retrospective analysis of 21 subjects treated with NIT and 21 subjects with periodontal endoscopy-aided scaling and root planing (PSRP) at baseline and 1-year evaluation was conducted...
December 3, 2023: BMC Oral Health
https://read.qxmd.com/read/38029354/assessment-of-bone-defect-morphology-for-the-adjunctive-use-of-bone-grafting-combined-with-enamel-matrix-derivative-a-3-year-cohort-study
#26
JOURNAL ARTICLE
Takanori Matsuura, Risako Mikami, Koji Mizutani, Hidehiro Shioyama, Norio Aoyama, Tomonari Suda, Yukako Kusunoki, Kohei Takeda, Yuichi Izumi, Jun Aida, Akira Aoki, Takanori Iwata
BACKGROUND: There have been limited studies with statistically sufficient sample sizes for assessment of suitable bone defect morphology for combination therapy with enamel matrix derivative (EMD) and bone grafting. The aim of this study was to investigate the appropriate feature of intrabony defects, such as bone defect angle (DA) and the containment by bony wall, for yielding the additional benefit of bone grafting in combination with periodontal regenerative therapy using EMD. METHODS: Following periodontal regenerative therapy using EMD with or without autologous bone grafting, 282 intrabony defects of 177 participants were maintained for 3 years...
November 29, 2023: Journal of Periodontology
https://read.qxmd.com/read/38004380/dp2-a-carbohydrate-derivative-enhances-in-vitro-osteoblast-mineralisation
#27
JOURNAL ARTICLE
Nissrine Ballout, Agnès Boullier, Walaa Darwiche, Katia Ait-Mohand, Eric Trécherel, Théo Gallégo, Cathy Gomila, Linda Yaker, Isabelle Gennero, José Kovensky, Jérôme Ausseil, Sylvestre Toumieux
Bone fracture healing is a complex biological process involving four phases coordinated over time: hematoma formation, granulation tissue formation, bony callus formation, and bone remodelling. Bone fractures represent a significant health problem, particularly among the elderly population and patients with comorbidities. Therapeutic strategies proposed to treat such fractures include the use of autografts, allografts, and tissue engineering strategies. It has been shown that bone morphogenetic protein 2 (BMP-2) has a therapeutic potential to enhance fracture healing...
October 24, 2023: Pharmaceuticals
https://read.qxmd.com/read/37995325/cell-based-therapy-by-autologous-bone-marrow-derived-mononuclear-cells-for-bone-augmentation-of-plate-stabilized-proximal-humeral-fractures-a-multicentric-randomized-open-phase-iia-study
#28
RANDOMIZED CONTROLLED TRIAL
Caroline Seebach, Christoph Nau, Dirk Henrich, Rene Verboket, Marlene Bellen, Nadine Frischknecht, Vivien Moeck, Kathrin Eichler, Kay Hajo Schmidt Horlohé, Reinhard Hoffmann, Halvard Bonig, Erhard Seifried, Johannes Frank, Ingo Marzi
Proximal humerus fractures are common in an aging population. The standard operative treatment is open reduction internal fixation (ORIF) using an angular stable plate. However, this procedure has complications such as a relatively high rate of secondary dislocation, humeral head necrosis or nonunion caused by delayed bony consolidation. Autologous bone marrow mononuclear cells (BMC) combined with a β-TCP scaffold could support bone healing and is considered clinically safe. This multicentric, randomized, open phase IIa clinical trial (Clinical Trials...
January 12, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/37992144/atypical-histological-presentation-of-bone-regeneration-after-insertion-of-cryoprotected-allogeneic-bone-graft
#29
JOURNAL ARTICLE
P Cruz, J-D Bortoli, E-B Benalcázar-Jalkh, S-M Boutros, M Bhola, F Grande, V-V Nayak, N Tovar, P-G Coelho, L Witek
BACKGROUND: To evaluate bone regenerative capacity of cryoprotected corticocancellous allogeneic bone graft performed in type II and III post-extraction sockets for ridge preservation after twelve weeks in-vivo. MATERIAL AND METHODS: Twenty-seven type II or III bony-walled extraction sockets (mandible and maxilla) were selected for this study. Following atraumatic tooth-extraction a cryoprotected corticocancellous allogeneic bone graft material and a resorbable porcine-derived collagen membrane were used for ridge preservation...
January 1, 2024: Medicina Oral, Patología Oral y Cirugía Bucal
https://read.qxmd.com/read/37967203/parathyroid-hormone-treatment-partially-reverses-endplate-remodeling-and-attenuates-low-back-pain-in-animal-models-of-spine-degeneration
#30
JOURNAL ARTICLE
Zemin Ling, Janet Crane, Hao Hu, Yan Chen, Mei Wan, Shuangfei Ni, Shadpour Demehri, Bahram Mohajer, Xinsheng Peng, Xuenong Zou, Xu Cao
Low back pain (LBP) is one of the most prevalent diseases affecting quality of life, with no disease-modifying therapy. During aging and spinal degeneration, the balance between the normal endplate (EP) bilayers of cartilage and bone shifts to more bone. The aged/degenerated bony EP has increased porosity because of osteoclastic remodeling activity and may be a source of LBP due to aberrant sensory innervation within the pores. We used two mouse models of spinal degeneration to show that parathyroid hormone (PTH) treatment induced osteogenesis and angiogenesis and reduced the porosity of bony EPs...
November 15, 2023: Science Translational Medicine
https://read.qxmd.com/read/37936308/the-impact-of-the-nasal-mucosal-flap-on-tissue-remodeling-after-sinus-bone-drilling-in-rabbit-models
#31
JOURNAL ARTICLE
Cao Lv, Cheng Li, Jing Qu, Yi Dong, Zhenxiao Huang, Yan Sun, Shunjiu Cui, Qian Huang, Bin Wang, Mingrui Huo, Bing Zhou
BACKGROUND: Frontal sinus surgery remained a challenge of restenosis or obliteration of the drainage pathway caused by the scarring and neo-osteogenesis after mucosal stripping and bone drill-out. The pedicled or free nasal mucosal flap is typically used to repair the exposed bone surface to avoid or reduce recurrence. OBJECTIVE: This study aimed to explore the histopathological mechanism of mucosal flaps repairing bare bone after mucosal resection and bone drill-out in the rabbit model...
November 7, 2023: American Journal of Rhinology & Allergy
https://read.qxmd.com/read/37927584/polymeric-nanocomposite-hydrogel-scaffold-for-jawbone-regeneration-the-role-of-rosuvastatin-calcium-loaded-silica-nanoparticles
#32
JOURNAL ARTICLE
Islam M Adel, Mohamed F ElMeligy, Mohammed S Amer, Nermeen A Elkasabgy
Bones are subject to different types of damages ranging from simple fatigue to profound defects. In serious cases, the endogenous healing mechanism is not capable of healing the damage or restoring the normal structure and function of the bony tissue. The aim of this research was to achieve a sustained delivery of rosuvastatin and assess its efficacy in healing bone tissue damage. Rosuvastatin was entrapped into silica nanoparticles and the system was loaded into an alginate hydrogel to be implanted in the damaged tissue...
December 15, 2023: International journal of pharmaceutics: X
https://read.qxmd.com/read/37921607/decontamination-and-repair-protocol-promotes-positive-outcomes-in-implants-affected-by-peri-implantitis-a-human-case-series
#33
JOURNAL ARTICLE
Marcos Ribeiro Sallé, Daniel Deluiz, Paul Fletcher, Monike F Santoro, Eduardo M B Tinoco
This study assessed the effectiveness and predictability of a readily available protocol to treat peri-implantitis utilizing mechanical debridement, chemical antiseptic surface detoxification, and osseous grafting. Nine patients (7 women, 2 men; mean age: 56.5 years) with 15 implants with peri-implantitis were included. Pocket probing depth (PPD), bleeding on probing (BOP), and standardized digital periapical radiographic measurements were taken. Surgical flaps were elevated, and the implant threads were cleaned with a plastic curette...
November 3, 2023: International Journal of Periodontics & Restorative Dentistry
https://read.qxmd.com/read/37906084/enhancing-craniofacial-bone-reconstruction-with-clinically-applicable-3d-bioprinted-constructs
#34
JOURNAL ARTICLE
Hyeongjin Lee, Carlos Kengla, Han Su Kim, Ickhee Kim, Jae-Gu Cho, Eric Renteria, Kyungsup Shin, Anthony Atala, James J Yoo, Sang Jin Lee
Medical imaging and 3D bioprinting can be used to create patient-specific bone scaffolds with complex shapes and controlled inner architectures. This study investigated the effectiveness of a biomimetic approach to scaffold design by employing geometric control. The biomimetic scaffold with a dense external layer showed improved bone regeneration compared to the control scaffold. New bone filled the defected region in the biomimetic scaffolds, while the control scaffolds only presented new bone at the boundary...
October 31, 2023: Advanced Healthcare Materials
https://read.qxmd.com/read/37898298/comparison-of-the-effectiveness-of-dfdba-and-t-prf-in-the-regeneration-of-intra-bony-defects-a-randomized-split-mouth-study
#35
JOURNAL ARTICLE
N Haripriya, Dr Mohan Kumar P, Dr Gautami S Penmetsa, Dr Nvs Sruthima G, Dr Ramesh Ksv, Dr Keerthi V
OBJECTIVES: This research intended to compare and evaluate the effectiveness of titanium-prepared platelet-rich fibrin (T-PRF) over demineralized freeze-dried bone allograft (DFDBA) in treating intra-bony defects based on the clinical and radiographic criteria. METHODS: This is a prospective randomized controlled, single-blinded split-mouth study where 15 patients with 30 intrabony defects were included. Subjects were randomly divided into T-PRF and DFDBA groups respectively...
October 26, 2023: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/37895083/berberine-encapsulated-poly-lactic-co-glycolic-acid-hydroxyapatite-plga-ha-microspheres-synergistically-promote-bone-regeneration-with-dopa-igf-1-via-the-igf-1r-pi3k-akt-mtor-pathway
#36
JOURNAL ARTICLE
Li Chen, Meng Tian, Jing Yang, Zhenxu Wu
Polymer microspheres have recently shown outstanding potential for bone tissue engineering due to their large specific surface area, good porosity, injectable property, good biocompatibility, and biodegradability. Their good load-release function and surface modifiability make them useful as a carrier of drugs or growth factors for the repair of bone defects in irregularly injured or complex microenvironments, such as skull defects. In this study, berberine (BBR)-encapsulated poly(lactic-co-glycolic acid) (PLGA)/hydroxyapatite (HA) microspheres were fabricated using electrified liquid jets and a phase-separation technique, followed by modification with the 3,4-hydroxyphenalyalanine-containing recombinant insulin-like growth-factor-1 (DOPA-IGF-1)...
October 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37892917/mesenchymal-stem-stromal-cells-immunomodulatory-and-bone-regeneration-potential-after-tumor-excision-in-osteosarcoma-patients
#37
REVIEW
Max Baron, Philip Drohat, Brooke Crawford, Francis J Hornicek, Thomas M Best, Dimitrios Kouroupis
Osteosarcoma (OS) is a type of bone cancer that is derived from primitive mesenchymal cells typically affecting children and young adults. The current standard of treatment is a combination of neoadjuvant chemotherapy and surgical resection of the cancerous bone. Post-resection challenges in bone regeneration arise. To determine the appropriate amount of bone to be removed, preoperative imaging techniques such as bone and CT scans are employed. To prevent local recurrence, the current standard of care suggests maintaining bony and soft tissue margins from 3 to 7 cm beyond the tumor...
October 13, 2023: Bioengineering
https://read.qxmd.com/read/37886403/three-dimensional-printed-hydroxyapatite-bone-substitutes-designed-by-a-novel-periodic-minimal-surface-algorithm-are-highly-osteoconductive
#38
JOURNAL ARTICLE
Ekaterina Maevskaia, Nupur Khera, Chafik Ghayor, Indranil Bhattacharya, Julien Guerrero, Flora Nicholls, Christian Waldvogel, Ralph Bärtschi, Lea Fritschi, Dániel Salamon, Mutlu Özcan, Patrick Malgaroli, Daniel Seiler, Michael de Wild, Franz E Weber
Autologous bone remains the gold standard bone substitute in clinical practice. Therefore, the microarchitecture of newly developed synthetic bone substitutes, which reflects the spatial distribution of materials in the scaffold, aims to recapitulate the natural bone microarchitecture. However, the natural bone microarchitecture is optimized to obtain a mechanically stable, lightweight structure adapted to the biomechanical loading situation. In the context of synthetic bone substitutes, the application of a Triply Periodic Minimum Surface (TPMS) algorithm can yield stable lightweight microarchitectures that, despite their demanding architectural complexity, can be produced by additive manufacturing...
October 1, 2023: 3D Printing and Additive Manufacturing
https://read.qxmd.com/read/37885712/evaluation-of-the-biocompatibility-antibacterial-and-anticancer-effects-of-a-novel-nano-structured-fe-mn-based-biodegradable-alloys-in-vitro-study
#39
JOURNAL ARTICLE
Samir Ali Elborolosy, Lamis Ahmed Hussein, Hamada Mahran, Hany R Ammar, S Sivasankaran, Safa Fathy Abd El-Ghani, Mohamed Yehia Abdelfattah, Ahmed Wael Abou-Zeid, Shereen Hafez Ibrahim, Mohamed Mostafa Elshamaa
SCIENTIFIC BACKGROUNDS: Development of nanostructured biodegradable alloys has generated a great deal of interest in the recent years as they offer promising bioactive materials for reconstruction of bony defects following traumatic fractures or surgical excision of tumors. OBJECTIVES: The aim of the current study was to investigate the biocompatibility of Iron-Manganese -based alloys (Fe-Mn) with addition of copper (Cu), Tungsten (W) and cobalt (Co) to obtain 3 different alloys namely, Fe-Mn-Cu, Fe-Mn-W, and Fe-Mn-Co on normal oral epithelial cell line,and their possible anticancer effect on MG-63: osteosarcoma cell line...
November 2023: Heliyon
https://read.qxmd.com/read/37873448/delivery-of-a-jagged1-peg-mal-hydrogel-with-pediatric-human-bone-cells-regenerates-critically-sized-craniofacial-bone-defects
#40
Archana Kamalakar, Brendan Tobin, Sundus Kaimari, Afra I Toma, Irica Moriarity, Surabhi Gautam, Pallavi Bhattaram, Shelly Abramowicz, Hicham Drissi, Andrés J García, Levi B Wood, Steven L Goudy
Treatments for congenital and acquired craniofacial (CF) bone abnormalities are limited and expensive. Current reconstructive methods include surgical correction of injuries, short-term bone stabilization, and long-term use of bone grafting solutions, including implantation of (i) allografts which are prone to implant failure or infection, (ii) autografts which are limited in supply. Current bone regenerative approaches have consistently relied on BMP-2 application with or without addition of stem cells. BMP2 treatment can lead to severe bony overgrowth or uncontrolled inflammation, which can accelerate further bone loss...
October 10, 2023: bioRxiv
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