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https://www.readbyqxmd.com/read/27910818/histomorphometric-and-transcriptome-evaluation-of-early-healing-bone-treated-with-a-novel-human-particulate-dentin-powder
#1
Yu-Chih Huang, Wei-Zhen Lew, Sheng-Wei Feng, Wei-Yi Lai, Yoshimitsu Abiko, Haw-Ming Huang
Human particulate dentin (HPD) shows potential as an alternative bone grafting material. However, the mechanism of bone healing at the molecular level after grafting with HPD is unclear. This study assessed the histological and global gene expression of bone tissues grafted with HPD. The HPD was prepared to 250-500 µm in size. X-ray diffraction (XRD) and energy dispersive x-ray spectroscopy (EDX) were performed to confirm the crystal structure, organic compound residues, and surface morphology, respectively...
December 2, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27896935/sandcastle-worm-inspired-blood-resistant-bone-graft-binder-using-a-sticky-mussel-protein-for-augmented-in-vivo-bone-regeneration
#2
Hyo Jeong Kim, Bong-Hyuk Choi, Sang Ho Jun, Hyung Joon Cha
Xenogenic bone substitutes are commonly used during orthopedic reconstructive procedures to assist bone regeneration. However, huge amounts of blood accompanied with massive bone loss usually increase the difficulty of placing the xenograft into the bony defect. Additionally, the lack of an organic matrix leads to a decrease in the mechanical strength of the bone-grafted site. For effective bone grafting, this study aims at developing a mussel adhesion-employed bone graft binder with great blood-resistance and enhanced mechanical properties...
November 29, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27869327/the-selective-serotonin-re-uptake-inhibitor-fluoxetine-directly-inhibits-osteoblast-differentiation-and-mineralization-during-fracture-healing-in-mice
#3
V Bradaschia-Correa, A M Josephson, D Mehta, M Mizrahi, S S Neibart, C Liu, O D Kennedy, A B Castillo, K A Egol, P Leucht
Chronic use of selective serotonin re-uptake inhibitors (SSRI) for the treatment of depression has been linked to osteoporosis. In this study, we investigated the effect of chronic SSRI use on fracture healing in two murine models of bone regeneration. First, we performed a comprehensive analysis of endochondral bone healing in a femur fracture model. C57/BL6 mice treated with fluoxetine, the most commonly prescribed SSRI, developed a normal cartilaginous soft-callus at 14 days after fracture and demonstrated a significantly smaller and biomechanically weaker bony hard-callus at 28 days...
November 21, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27860377/local-application-of-lactoferrin-promotes-bone-regeneration-in-a-rat-critical-sized-calvarial-defect-model-as-demonstrated-by-micro-ct-and-histological-analysis
#4
Ryan Gao, Maureen Watson, Karen E Callon, Donna Tuari, Michael S Dray, Dorit Naot, Satya Amirapu, Jacob T Munro, Jillian Cornish, David S Musson
Lactoferrin is a multifunctional glycoprotein with therapeutic potential for bone tissue engineering. The aim of this study was to assess the efficacy of local application of lactoferrin on bone regeneration. Five-millimetre critical-sized defects were created over the right parietal bone in 64 Sprague-Dawley rats. The rats were randomized into four groups: group 1 (n = 20) had empty defects; group 2 (n = 20) had defects grafted with collagen gels (3 mg/mL); group 3 (n = 20) had defects grafted with collagen gels impregnated with bovine lactoferrin (10 µg/gel) and group 4 (n = 4) had sham surgeries (skin and periosteal incisions only)...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27834419/limitations-and-options-using-resorbable-versus-nonresorbable-membranes-for-successful-guided-bone-regeneration
#5
Nikolaos K Soldatos, Popi Stylianou, Vasiliki P Koidou, Nikola Angelov, Raymond Yukna, Georgios E Romanos
OBJECTIVE: Deficient bony ridges often complicate the implant treatment plan. Several treatment modalities are used to regenerate bone, including guided bone regeneration (GBR). The purpose of this study was to summarize the knowledge on different types of membranes available and currently used in GBR procedures in a staged approach or with simultaneous implant placement. The primary role of the membranes is to exclude epithelial and connective tissue cells from the wound area to be regenerated, and to create and maintain the space into which pluripotential and osteogenic cells are free to migrate...
November 10, 2016: Quintessence International
https://www.readbyqxmd.com/read/27790579/pure-titanium-membrane-ultra-ti-%C3%A2-in-the-treatment-of-periodontal-osseous-defects-a-split-mouth-comparative-study
#6
Rashmi Khanna, Rajeev Khanna, Nilesh Dinesh Pardhe, Nancy Srivastava, Manas Bajpai, Shailendra Gupta
INTRODUCTION: Although many different types of Guided Tissue Regeneration (GTR) membranes (resorbable/non-resorbable, including titanium mesh) have been used in the field of Periodontics till now, but this is the first and only clinical study testing the effectiveness of an ultra thin pure Titanium Membrane (Ultra Ti) as a GTR membrane in infra-bony periodontal defects. AIM: To compare the efficacy of GTR in intra-bony defects with newly introduced non-resorbable barrier membrane, made of titanium called "Ultra-Ti (®) GTR Membrane" versus open flap debridement...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27766028/targeting-p38-pathway-regulates-bony-formation-via-msc-recruitment-during-mandibular-distraction-osteogenesis-in-rats
#7
Zi-Hui Yang, Bao-Lei Wu, Chen Ye, Sen Jia, Xin-Jie Yang, Rui Hou, De-Lin Lei, Lei Wang
Distraction osteogenesis (DO) is a widely used self-tissue engineering. However, complications and discomfort due to the long treatment period are still the bottleneck of DO. Novel strategies to accelerate bone formation in DO are still needed. P38 is capable of regulating the osteogenic differentiation of both mesenchymal stem cells (MSCs) and osteoblasts, which are crucial to bone regeneration. However, it is not clear whether targeting p38 could regulate bony formation in DO. The purpose of the current work was to investigate the effects of local application of either p38 agonist anisomycin or p38 inhibitor SB203580 in a rat model of DO...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27762665/sutures-possess-strong-regenerative-capacity-for-calvarial-bone-injury
#8
Shery Park, Hu Zhao, Mark Urata, Yang Chai
Repair of calvarial bony defects remains challenging for craniofacial surgeons. Injury experiments on animal calvarial bones are widely used to study healing mechanisms and test tissue engineering approaches. Previously, we identified Gli1+ cells within the calvarial sutures as stem cells supporting calvarial bone turnover and injury repair. In this study, we tested the regenerative capacity of the suture region compared with other areas of calvarial bone. Injuries were made to mouse sagittal sutures or other areas of the calvarial bone at varying distances from the suture...
December 1, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27673512/short-link-n-can-induce-regeneration-of-the-early-degenerate-intervertebral-disc-in-a-novel-long-term-organ-culture-model-that-includes-the-bony-vertebrae
#9
Nizar Algarni, Michael Grant, Laura M Epure, Omar Salem, Rakan Farouk Bokhari, John Antoniou, Fackson Mwale
Link N (DHLSDNYTLDHDRAIH), is a naturally occurring peptide that can stimulate matrix production in vitro, in vivo and in intact ex vivo human intervertebral discs (IVDs). We have recently discovered that annulus fibrosus cells (AF) cells have the ability to proteolytically process Link N resulting in a fragment spanning amino acid residues 1-8 short Link N (sLink N). Separately, we recently developed and validated a large animal disc organ culture model that maintains long-term cell viability while retaining the bony endplates and vertebral bone (vIVDs; IVD with intact vertebrae)...
September 27, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27636714/accelerated-bony-defect-healing-based-on-chitosan-thermosensitive-hydrogel-scaffolds-embedded-with-chitosan-nanoparticles-for-the-delivery-of-bmp2-plasmid-dna
#10
Hui Li, Qiuxia Ji, Ximin Chen, Yan Sun, Quanchen Xu, Panpan Deng, Fang Hu, Jianjun Yang
Regeneration of alveolar bone is among the main purposes of periodontal treatment. However, it is a challenge for both dentists and patients. An injectable chitosan-based thermosensitive hydrogel scaffold (CS/CSn-GP) was successfully designed and prepared with the incorporation of bone morphogenetic protein-2 plasmid DNA (pDNA-BMP2)-loaded chitosan nanoparticles (CS/CSn(pDNA-BMP2)-GP) in this study. The aim of this study was to evaluate the regenerative effect of this scaffold on the endogenous repair of alveolar bone...
January 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27622454/invagination-of-the-sphenoid-sinus-mucosa-after-endoscopic-endonasal-transsphenoidal-approach-and-its-significance
#11
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Jae-Sung Park, Ki Hwan Jung, Soo Whan Kim, Jin Hee Cho, Yong Jin Park, Yun Jin Kang, Sung Won Kim
OBJECTIVE: To describe the clinical features of invagination of the sphenoid sinus mucosa (ISM) and compare them with other similar cases using a visual analog scale (VAS) to assess the various nasal symptoms and to discuss its clinical significance and means of prevention. STUDY DESIGN: Retrospective chart review at a tertiary referral center. METHODS: Between 2010 and 2015, 8 patients who had undergone EETSA surgery displayed postoperative ISM...
2016: PloS One
https://www.readbyqxmd.com/read/27562221/synergistic-approach-using-platelet-rich-fibrin-and-1-alendronate-for-intrabony-defect-treatment-in-chronic-periodontitis-a-randomized-clinical-trial
#12
Dharmendra Kanoriya, A R Pradeep, Sandeep Singhal, Vibhuti Garg, C N Guruprasad
BACKGROUND: Platelet-rich fibrin (PRF) is a reservoir of concentrated platelets that provides a pool of biologic growth-promoting factors and cytokines, which help in mediating regeneration of lost bone and soft tissue maturation. Alendronate (ALN), a member of the amino-bisphosphonate group, is known to enhance periodontal tissue regeneration by inhibiting osteoclast-mediated bone resorption and promoting osteoblast-mediated osteogenesis. The current intervention aims to assess combined effectiveness of PRF and 1% ALN with access therapy in intrabony defect (IBD) treatment in patients with chronic periodontitis (CP)...
December 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27554771/analysis-of-genomewide-dna-methylation-reveals-differences-in-dna-methylation-levels-between-dormant-and-naturally-as-well-as-artificially-potentiated-pedicle-periosteum-of-sika-deer-cervus-nippon
#13
Chun Yang, Xiao Lu, Hongmei Sun, Wen Hui Chu, Chunyi Li
Deer antlers are the only mammalian appendages that can fully regenerate each year from the permanent bony protuberances of the frontal bones, called pedicles. Pedicle periosteum (PP) is the key tissue for antler regeneration and the source of antler stem cells. The distal one third of the PP has acquired the ability to regenerate antlers and is termed the potentiated PP (PPP), whereas the proximal two thirds of the PP requires further interactions within its niche to launch antler regeneration and is termed the dormant PP (DPP)...
September 2016: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/27532945/regenerative-medicine-in-facial-plastic-and-reconstructive-surgery-a-review
#14
Matthew Q Miller, Abhijit Dighe, Quanjun Cui, Stephen S Park, J Jared Christophel
The field of regenerative medicine aims at enhancing tissue healing and regeneration through the exogenous addition of therapeutic growth factors and cells, often in combination with tissue-compatible scaffolds. Perhaps the biggest advances in facial plastic and reconstructive surgery (FPRS) in the coming years will be the result of regenerative medicine techniques. While many articles on regenerative medicine have been published in the FPRS literature, to our knowledge there are no reviews that describe both soft-tissue and bony regeneration strategies, including scaffolds, stem cells, growth factors, and platelet-rich plasma...
September 1, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27517073/epithelialization-over-a-scaffold-of-antibiotic-impregnated-pmma-beads-a-salvage-technique-for-open-tibial-fractures-with-bone-and-soft-tissue-loss-when-all-else-fails
#15
Karim Z Masrouha, Youssef El-Bitar, Marc Najjar, Said Saghieh
The management of soft tissue defects in tibial fractures is essential for limb preservation. Current techniques are not without complications and may lead to poor functional outcomes. A salvage method is described using three illustrative cases whereby a combination of flaps and antibiotic-impregnated polymethylmethacrylate beads are employed to fill the bony defect, fight the infection, and provide a surface for epithelial regeneration and secondary wound closure. This was performed after the partial failure of all other options...
June 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27504535/clinical-and-microcomputed-topography-evaluation-of-the-concentrated-growth-factors-as-a-sole-material-in-a-cystic-bony-defect-in-alveolar-bone-followed-by-dental-implantation-a-case-report
#16
Shih-Shiun Shyu, Earl Fu, E-Chin Shen
Concentrated growth factors (CGFs) can be used to enhance wound healing. This case report describes a short-term effect of CGF grafting followed by implant placement in a cystic bony defect within the mandible. Healing conditions were monitored by 2 implant-related surgeries, radiographs, and a microcomputed topography examination. Continuous increase of radiopacity in radiographs was noticed till 6 months after grafting. Bone core specimen was taken at 3.5 months after grafting, and percent bone volume reached 32...
October 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27485371/biological-effects-of-compressive-forces-exerted-on-particulate-bone-grafts-during-socket-preservation-animal-study
#17
Rafael Delgado-Ruiz, Georgios E Romanos, Sergio Alexandre Gerhke, Gerardo Gomez-Moreno, José Eduardo Maté-Sánchez de Val, José Luis Calvo-Guirado
OBJECTIVES: To compare different compressive forces exerted on a particulate graft material during socket preservation and their effects on bone regeneration. MATERIAL AND METHODS: Six male dogs were used. The second, third, and fourth premolars, and the first molar were extracted bilaterally at the lower jaws. A particulate synthetic biphasic grafting material (60% HA and 40% β-tricalcium phosphate) was used. Three different standardized compressive forces were applied randomly during the socket preservation...
August 2, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27444291/acceleration-of-osteogenesis-by-platelet-rich-plasma-with-acellular-dermal-matrix-in-a-calvarial-defect-model
#18
Woon Hyeok Jeong, Tai Suk Roh, Young Seok Kim, Eun Hye Kang, Bok Ki Jung, Won Jai Lee, Dae Hyun Lew, In Sik Yun
PURPOSE: The effects of platelet-rich plasma (PRP) on improvement of bone regeneration have been widely investigated. However, use of a proper scaffold is also important to the delivery of bioactive materials. The aim of this study was to analyze the effects of PRP with acellular dermal matrix (ADM) as a bone substitute in a cranial defect model. METHODS: Twenty-nine New Zealand white rabbits were randomly divided into four groups including control, PRP, ADM, and PRP with ADM...
September 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27435058/nerve-regeneration-techniques-respecting-the-special-characteristics-of-the-inferior-alveolar-nerve
#19
Ansgar C Hergt, Benedicta E Beck-Broichsitter, Jan Raethjen, Nathalie Käser, Michael Hülsmann, Jörg Wiltfang, Jörg Heine, Stephan T Becker
PURPOSE: The aim of this study was to examine the in situ regeneration of the inferior alveolar nerve (IAN) in its bony channel, using autologous tissue in combination with a recombinant human nerve growth factor (rhNGF). MATERIALS AND METHODS: A total of 20 New Zealand rabbits were randomly divided into five groups. Following dissection of the IAN, the animals underwent reconstruction either with muscle tissue (groups 1 and 2) or with fat tissue (groups 3 and 4)...
September 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27410432/inhibition-of-midkine-augments-osteoporotic-fracture-healing
#20
Melanie Haffner-Luntzer, Julia Kemmler, Verena Heidler, Katja Prystaz, Thorsten Schinke, Michael Amling, Anna Kovtun, Anna E Rapp, Anita Ignatius, Astrid Liedert
The heparin-binding growth and differentiation factor midkine (Mdk) is proposed to negatively regulate osteoblast activity and bone formation in the adult skeleton. As Mdk-deficient mice were protected from ovariectomy (OVX)-induced bone loss, this factor may also play a role in the pathogenesis of postmenopausal osteoporosis. We have previously demonstrated that Mdk negatively influences bone regeneration during fracture healing. Here, we investigated whether the inhibition of Mdk using an Mdk-antibody (Mdk-Ab) improves compromised bone healing in osteoporotic OVX-mice...
2016: PloS One
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