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https://www.readbyqxmd.com/read/29767473/prediction-of-callus-subsidence-in-distraction-osteogenesis-using-callus-formation-scoring-system-preliminary-study
#1
Panlop Tirawanish, Perajit Eamsobhana
OBJECTIVE: To develop the scoring system which describes both quality and quantity of callus formation to predict the callus subsidence. METHODS: Forty-seven bony segments with an average lengthening of 5.17 ± 2.83 cm were included. The score was calculated based on the amount of callus classified in five patterns and the summation with the density of the callus classified in four patterns; the total score was 9. Bony subsidence >10% or >10° angulation were considered significant...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29756133/biology-of-teeth-and-implants-host-factors-pathology-regeneration-and-the-role-of-stem-cells
#2
F-Michael Eggert, Liran Levin
In chronic periodontitis and peri-implantitis, cells of the innate and adaptive immune systems are involved directly in the lesions within the tissues of the patient. Absence of a periodontal ligament around implants does not prevent a biologic process similar to that of periodontitis from affecting osseointegration. Our first focus is on factors in the biology of individuals that are responsible for the susceptibility of such individuals to chronic periodontitis and to peri-implantitis. Genetic factors are of significant importance in susceptibility to these diseases...
2018: Quintessence International
https://www.readbyqxmd.com/read/29752384/a-regulatory-pathway-involving-retinoic-acid-and-calcineurin-demarcates-and-maintains-joint-cells-and-osteoblasts-in-the-fin-regenerate
#3
Stephanie C McMillan, Jing Zhang, Hue-Eileen Phan, Shirine Jeradi, Leona Probst, Matthias Hammerschmidt, Marie-Andrée Akimenko
During zebrafish fin regeneration, blastema cells lining the epidermis differentiate into osteoblasts and joint cells to reconstruct the segmented bony rays. We show that osteoblasts and joint cells originate from a common cell lineage, but are committed to different cell fates. Pre-osteoblasts expressing runx2a/b commit to the osteoblast lineage upon expressing sp7 , while the strong upregulation of hoxa13a correlates with a commitment to a joint cell type. In the distal regenerate, hoxa13a , evx1, and pthlha are sequentially upregulated at regular intervals to define the newly identified presumptive joint cells...
May 11, 2018: Development
https://www.readbyqxmd.com/read/29701097/-rail-and-nail-bifocal-management-of-atrophic-femoral-nonunion
#4
K Davda, N Heidari, P Calder, D Goodier
Aims The management of a significant bony defect following excision of a diaphyseal atrophic femoral nonunion remains a challenge. We present the outcomes using a combined technique of acute femoral shortening, stabilized with a long retrograde intramedullary nail, accompanied by bifocal osteotomy compression and distraction osteogenesis with a temporary monolateral fixator. Patients and Methods Eight men and two women underwent the 'rail and nail' technique between 2008 and 2016. Proximal locking of the nail and removal of the external fixator was undertaken once the length of the femur had been restored and prior to full consolidation of the regenerate...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29680264/temporary-inhibition-of-the-plasminogen-activator-inhibits-periosteal-chondrogenesis-and-promotes-periosteal-osteogenesis-during-appendicular-bone-fracture-healing
#5
D Bravo, A M Josephson, V Bradaschia-Correa, M Z Wong, N L Yim, S S Neibart, S N Lee, J Huo, T Coughlin, M M Mizrahi, P Leucht
INTRODUCTION: Aminocaproic acid is approved as an anti-fibrinolytic for use in joint replacement and spinal fusion surgeries to limit perioperative blood loss. Previous animal studies have demonstrated a pro-osteogenic effect of aminocaproic acid in spine fusion models. Here, we tested if aminocaproic acid enhances appendicular bone healing and we sought to uncover the effect of aminocaproic acid on osteoprogenitor cells (OPCs) during bone regeneration. METHODS: We employed a well-established murine femur fracture model in adult C57BL/6J mice after receiving two peri-operative injections of aminocaproic acid...
April 19, 2018: Bone
https://www.readbyqxmd.com/read/29671294/standard-of-care-controversies-and-innovations-in-the-medical-treatment-of-severe-traumatic-brain-injury-stbi
#6
Alba Scerrati, Silvia De Rosa, Lorenzo Mongardi, Michele A Cavallo, Giorgio Trapella, Pasquale De Bonis
Severe traumatic brain injury (STBI) is characterized by a primary injury which cannot be reversed and a secondary injury that can be prevented or reversed. Management of STBI patients in intensive care mainly aims at preventing the secondary injury. Treatment aims to: reducing ICP pressure (that can result in an ischemic insult); avoiding hypotension, hyperthermia, or hypoxemia; maintaining a normal electrolytes homeostasis; treating the Autonomic dysfunction syndrome, coagulopathies, Acute Kidney Injury and maintaining an adequate nutrition...
April 18, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29662086/persistence-of-the-abcc6-genes-and-the-emergence-of-the-bony-skeleton-in-vertebrates
#7
Bruna Parreira, João C R Cardoso, Rita Costa, Ana Rita Couto, Jácome Bruges-Armas, Deborah M Power
The ATP-binding cassette transporter 6 (ABCC6) gene encodes a cellular transmembrane protein transporter (MRP6) that is involved in the regulation of tissue calcification in mammals. Mutations in ABCC6 are associated with human ectopic calcification disorders. To gain insight into its evolution and involvement in tissue calcification we conducted a comparative analysis of the ABCC6 gene and the related gene ABCC1 from invertebrates to vertebrates where a bony endoskeleton first evolved. Taking into consideration the role of ABCC6 in ectopic calcification of human skin we analysed the involvement of both genes in the regeneration of scales, mineralized structures that develop in fish skin...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608393/histological-comparison-of-new-bone-formation-using-amnion-membrane-graft-vs-resorbable-collagen-membrane-an-animal-study
#8
Soheil Koushaei, Mohammad Hassan Samandari, Sayed Mohammad Razavi, Ahad Khoshzaban, Shahriar Adibi, Payam Varedi
The purpose of this article was to evaluate the bone induction effects of an amnion membrane protected graft compared with collagen membrane protected graft in repair of tibial bony defects in dogs. This study was performed using the tibial bone of dogs. After the removal of periostium, similar holes were made with a 16 mm trephine drill (38 holes in total). For the study group ten holes were covered by absorbable collagen and 16 holes by amniotic membrane. In control group 12 holes were made and were covered by the overlying soft tissue...
April 2, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29599032/femoral-bone-restoration-patterns-in-revision-total-hip-arthroplasty-using-distally-fixed-modular-tapered-titanium-stems-and-an-extended-trochanteric-osteotomy-approach
#9
Andreas Ladurner, Vilijam Zdravkovic, Karl Grob
BACKGROUND: Mechanical failure of modular revision stems is a serious complication in revision total hip arthroplasty. The lack of adequate osseous support to the proximal component, especially in cases of an extended trochanteric osteotomy approach, is considered a risk factor for stem failure. In this study, we analyze proximal bone regeneration patterns in patients undergoing revision total hip arthroplasty for aseptic stem loosening through an extended trochanteric osteotomy approach using an uncemented dual modular stem...
February 26, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29582951/-from-the-lab-bench-to-the-patient-can-injured-skeletal-tissues-regenerate
#10
REVIEW
Amir Haze, Josh Schroeder, Anat Blumenfeld, Meir Liebergall, Shaul Beyth
Regenerative medicine research has evolved significantly in recent years. There is a great un-met clinical need for developing new treatments that will induce regeneration of injured skeletal tissues in cases such as large bony defects caused by trauma or tumor resection, articular cartilage defects and torn or degenerate tendons and ligaments. Except for bone that can regenerate small defects, all other skeletal tissues do not hold the natural capability for regeneration after injury and rather form a less functional scar tissue...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29557992/comparison-of-three-block-bone-substitutes-for-bone-regeneration-long-term-observation-in-the-beagle-dog
#11
Kosaku Sawada, Ken Nakahara, Maiko Haga-Tsujimura, Tateyuki Iizuka, Masako Fujioka-Kobayashi, Kensuke Igarashi, Nikola Saulacic
This study aimed to evaluate the impact of three types of block bone substitute material on bone formation and graft resorption in vivo. Standardized bone defects (n = 4 defects/animal) were created in the calvaria of nine dogs. Block bone substitutes made of deproteinized bovine bone mineral (DBBM), beta-tricalcium phosphate (β-TCP) and a mixture alpha-TCP and hydroxyapatite (α-TCP/HA) were inserted into the bone defects. A fourth defect was left untreated (empty). All sites were covered with a collagenous membrane...
March 20, 2018: Odontology
https://www.readbyqxmd.com/read/29557403/one-stage-horizontal-guided-bone-regeneration-with-autologous-bone-anorganic-bovine-bone-and-collagen-membranes-follow-up-of-a-prospective-study-30-months-after-loading
#12
Silvio Mario Meloni, Sascha Alexander Jovanovic, Milena Pisano, Giacomo De Riu, Edoardo Baldoni, Marco Tallarico
PURPOSE: To present the medium-term results of one-stage guided bone regeneration (GBR) using autologous bone and anorganic bovine bone, placed in layers, in association with resorbable collagen membranes, for the reconstruction of horizontal bony defects. MATERIALS AND METHODS: This study was designed as an uncontrolled prospective study. Partially edentulous patients, having less than 6.0 mm and more than 4.0 mm of residual horizontal bone width were selected and consecutively treated with simultaneously implant installation and bone regeneration by using 2...
2018: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29556455/can-corticotomy-with-or-without-bone-grafting-expand-the-limits-of-safe-orthodontic-therapy
#13
Federico Brugnami, Alfonso Caiazzo, Pushkar Mehra
Purpose: To assess whether concomitant particulate bone grafting makes a difference in the ability to safely orthodontically reposition teeth outside the bony envelope after corticotomy. Material and methods: Retrospective analysis of patients who underwent corticotomy as part of their orthodontic therapy for treatment of severe crowding. Patients were divided as: a) Group 1: corticotomy with bone grafting, and, b) Group 2: corticotomy without bone grafting. CT scan examinations were performed before and at the end of the treatment...
January 2018: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29497762/pharmacological-inhibition-of-il-6-trans-signaling-improves-compromised-fracture-healing-after-severe-trauma
#14
Kathrin Kaiser, Katja Prystaz, Anna Vikman, Melanie Haffner-Luntzer, Stephanie Bergdolt, Gudrun Strauss, Georg H Waetzig, Stefan Rose-John, Anita Ignatius
Patients with multiple injuries frequently suffer bone fractures and are at high risk to develop fracture healing complications. Because of its key role both in systemic posttraumatic inflammation and fracture healing, the pleiotropic cytokine interleukin-6 (IL-6) may be involved in the pathomechanisms of trauma-induced compromised fracture healing. IL-6 signals are transmitted by two different mechanisms: classic signaling via the membrane-bound receptor (mIL-6R) and trans-signaling via its soluble form (sIL-6R)...
May 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29481504/autologous-bone-marrow-concentrates-and-concentrated-growth-factors-accelerate-bone-regeneration-after-enucleation-of-mandibular-pathologic-lesions
#15
Wael M Talaat, Mohamed M Ghoneim, Omar Salah, Osama A Adly
Stem cell therapy is a revolutionary new way to stimulate mesenchymal tissue regeneration. The platelets concentrate products started with platelet-rich plasma (PRP), followed by platelet-rich fibrin (PRF), whereas concentrated growth factors (CGF) are the latest generation of the platelets concentrate products which were found in 2011. The aim of the present study was to evaluate the potential of combining autologous bone marrow concentrates and CGF for treatment of bone defects resulting from enucleation of mandibular pathologic lesions...
February 23, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29478251/horizontal-bone-augmentation-procedures-in-implant-dentistry-prosthetically-guided-regeneration
#16
REVIEW
Matteo Chiapasco, Paolo Casentini
The rehabilitation of partially or totally edentulous patients with implant-supported prostheses has become routine, with excellent long-term outcome. A proper implant position is mandatory to achieve good functional and esthetic outcome and may require an adequate amount of alveolar bone and surrounding soft tissue. When this is lacking because of atrophy, sequelae of periodontal disease, traumas or congenital malformations, increased bone volume and/or keratinized mucosa can be obtained by guided bone regeneration, bone-grafting techniques and alveolar bone expansion...
June 2018: Periodontology 2000
https://www.readbyqxmd.com/read/29466922/rabbit-calvarial-defect-model-for-customized-3d-printed-bone-grafts
#17
Kang-Gon Lee, Kang-Sik Lee, Yu-Jeoung Kang, Jong-Hyun Hwang, Se-Hwan Lee, Sang-Hyug Park, Yongdoo Park, Young-Sam Cho, Bu-Kyu Lee
Bone graft materials are commonly used to regenerate various bone defects, but their application is often limited because of the complex defect shape in various clinical conditions. Hence, customized bone grafts using three-dimensional (3D) printing techniques have been developed. However, conventional simple bone defect models are limited for evaluating the benefits and manufacturing accuracy of 3D-printed customized bone grafts. Thus, the aim of the present study was to develop a complex-shaped bone defect model...
May 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29456311/management-of-fenestration-using-bone-allograft-in-conjunction-with-platelet-rich-fibrin
#18
Anuradha Bhatsange, Alkesh Shende, Sabina Deshmukh, Sharanabasappa Japatti
Fenestration and dehiscence are said to be anatomical variations of cortical bone and not true pathological entities. They represent window-like defects covered by periosteum and overlying gingiva with or without the intact marginal bone. The etiology of such defects is still unclear, though many hypotheses such as occlusal traumatism, trauma, and variation in root bone angulation have been put forward. Diagnosis of such defects is challenging clinically, and they cannot be appreciated in conventional radiographs...
July 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29453780/bone-conditioned-medium-modulates-the-osteoconductive-properties-of-collagen-membranes-in-a-rat-calvaria-defect-model
#19
Ulrike Kuchler, Tina Rybaczek, Toni Dobask, Patrick Heimel, Stefan Tangl, Jessica Klehm, Matthias Menzel, Reinhard Gruber
OBJECTIVES: Collagen membranes are not limited to be occlusive barriers as they actively support bone regeneration. However, the impact of bone-derived growth factors on their osteoconductive competence has not been examined. METHODS: Twenty adult Sprague Dawley rats were included in the study. Calvaria defects with a diameter of five millimeter were created. The defect was covered with one layer of a collagen membrane previously soaked in conditioned medium of porcine bone chips or in culture medium alone...
April 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29433544/scaffolds-for-the-repair-of-bone-defects-in-clinical-studies-a-systematic-review
#20
REVIEW
Jian-Hua Zeng, Shi-Wei Liu, Long Xiong, Peng Qiu, Ling-Hua Ding, Shi-Lang Xiong, Jing-Tang Li, Xin-Gen Liao, Zhi-Ming Tang
BACKGROUND: This systematic review aims to summarize the clinical studies on the use of scaffolds in the repair of bony defects. METHODS: The relevant articles were searched through PubMed database. The following keywords and search terms were used: "scaffolds," "patient," "clinic," "bone repair," "bone regeneration," "repairing bone defect," "repair of bone," "osteanagenesis," "osteanaphysis," and "osteoanagenesis...
February 12, 2018: Journal of Orthopaedic Surgery and Research
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