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bony regenerate

Kathrin Kaiser, Katja Prystaz, Anna Vikman, Melanie Haffner-Luntzer, Stephanie Bergdolt, Gudrun Strauss, Georg H Waetzig, Stefan Rose-John, Anita Ignatius
Patients with multiple injuries frequently suffer bone fractures and are at high risk to develop fracture healing complications. Because of its key role both in systemic posttraumatic inflammation and fracture healing, the pleiotropic cytokine interleukin-6 (IL-6) may be involved in the pathomechanisms of trauma-induced compromised fracture healing. IL-6 signals are transmitted by two different mechanisms: classic signaling via the membrane-bound receptor (mIL-6R) and trans-signaling via its soluble form (sIL-6R)...
March 1, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Wael M Talaat, Mohamed M Ghoneim, Omar Salah, Osama A Adly
Stem cell therapy is a revolutionary new way to stimulate mesenchymal tissue regeneration. The platelets concentrate products started with platelet-rich plasma (PRP), followed by platelet-rich fibrin (PRF), whereas concentrated growth factors (CGF) are the latest generation of the platelets concentrate products which were found in 2011. The aim of the present study was to evaluate the potential of combining autologous bone marrow concentrates and CGF for treatment of bone defects resulting from enucleation of mandibular pathologic lesions...
February 23, 2018: Journal of Craniofacial Surgery
Matteo Chiapasco, Paolo Casentini
The rehabilitation of partially or totally edentulous patients with implant-supported prostheses has become routine, with excellent long-term outcome. A proper implant position is mandatory to achieve good functional and esthetic outcome and may require an adequate amount of alveolar bone and surrounding soft tissue. When this is lacking because of atrophy, sequelae of periodontal disease, traumas or congenital malformations, increased bone volume and/or keratinized mucosa can be obtained by guided bone regeneration, bone-grafting techniques and alveolar bone expansion...
February 25, 2018: Periodontology 2000
Kang-Gon Lee, Kang-Sik Lee, Yu-Jeoung Kang, Jong-Hyun Hwang, Se-Hwan Lee, Sang-Hyug Park, Yongdoo Park, Young-Sam Cho, Bu-Kyu Lee
Bone graft materials are commonly used to regenerate various bone defects, but their application is often limited because of the complex defect shape in various clinical conditions. Hence, customized bone grafts using three-dimensional (3D) printing techniques have been developed. However, conventional simple bone defect models are limited for evaluating the benefits and manufacturing accuracy of 3D-printed customized bone grafts. Thus, the aim of the present study was to develop a complex-shaped bone defect model...
February 21, 2018: Tissue Engineering. Part C, Methods
Anuradha Bhatsange, Alkesh Shende, Sabina Deshmukh, Sharanabasappa Japatti
Fenestration and dehiscence are said to be anatomical variations of cortical bone and not true pathological entities. They represent window-like defects covered by periosteum and overlying gingiva with or without the intact marginal bone. The etiology of such defects is still unclear, though many hypotheses such as occlusal traumatism, trauma, and variation in root bone angulation have been put forward. Diagnosis of such defects is challenging clinically, and they cannot be appreciated in conventional radiographs...
July 2017: Journal of Indian Society of Periodontology
Ulrike Kuchler, Tina Rybaczek, Toni Dobask, Patrick Heimel, Stefan Tangl, Jessica Klehm, Matthias Menzel, Reinhard Gruber
OBJECTIVES: Collagen membranes are not limited to be occlusive barriers as they actively support bone regeneration. However, the impact of bone-derived growth factors on their osteoconductive competence has not been examined. METHODS: Twenty adult Sprague Dawley rats were included in the study. Calvaria defects with a diameter of five millimeter were created. The defect was covered with one layer of a collagen membrane previously soaked in conditioned medium of porcine bone chips or in culture medium alone...
February 16, 2018: Clinical Oral Implants Research
Jian-Hua Zeng, Shi-Wei Liu, Long Xiong, Peng Qiu, Ling-Hua Ding, Shi-Lang Xiong, Jing-Tang Li, Xin-Gen Liao, Zhi-Ming Tang
BACKGROUND: This systematic review aims to summarize the clinical studies on the use of scaffolds in the repair of bony defects. METHODS: The relevant articles were searched through PubMed database. The following keywords and search terms were used: "scaffolds," "patient," "clinic," "bone repair," "bone regeneration," "repairing bone defect," "repair of bone," "osteanagenesis," "osteanaphysis," and "osteoanagenesis...
February 12, 2018: Journal of Orthopaedic Surgery and Research
Yurie Yamada, Atsushi Ohazama, Takeyasu Maeda, Kenji Seo
Activation of Shh signaling is known to be observed following injury of the peripheral nerves such as the sciatic nerve. However, the precise role of Shh signaling during peripheral nerve regeneration is not fully understood. The inferior alveolar nerve (IAN) is most commonly injured during oral surgery. Unlike the sciatic nerve, the IAN is isolated from other craniofacial tissues, as it resides in a long bony canal within the mandible. The IAN is thus an excellent experimental model for investigating peripheral nerve regeneration...
February 8, 2018: Neuroscience Letters
Sepanta Hosseinpour, Maryam Rezai Rad, Arash Khojasteh, Homa Zadeh
BACKGROUND: Currently, antibodies are progressively applied in medicine for different purposes from diagnosis to treatments. Over twenty monoclonal antibodies utilized for many therapeutic reasons from therapy of cancers, immune disorders, and osteoporosis to localized bony defects. In addition, therapeutic antibodies represented various findings in bone tissue engineering. OBJECTIVES: The current study aims to systematically review the available literature on antibody assisted bone regeneration in animal models...
February 6, 2018: Current Stem Cell Research & Therapy
Mayte Buchbender, Friedrich W Neukam, Rainer Lutz, Christian M Schmitt
OBJECTIVES: In this systematic review, we aimed to assess the impact of filling or not filling enucleated odontogenic jaw cysts on bony defect consolidation. In terms of filling, we aimed to assess which is the best filling material based on current evidence. STUDY DESIGN: An electronic search was performed using PubMed, Embase, and MEDLINE databases with the logical operators: "odontogenic cysts" AND "jaw cysts" AND "treatment AND therapy...
December 29, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Yashmi Jaiswal, Sanjeev Kumar, Vijay Mishra, Puneet Bansal, Kumar Rakshak Anand, Sukumar Singh
Aim: To access the efficacy of decalcified freeze-dried bone allograft (DFDBA) in the regeneration of bone following small osseous defect in minor oral surgery. Objectives: To evaluate the ability of DFDBA to enhance the rate of wound healing and assess radiographic bone density, pain, and infection preoperatively and postoperatively. Materials and Methods: Twenty patients with cysts were assessed. Ten patients were filled with DFDBA (Group 1) and ten without bone graft (Group 2), respectively...
July 2017: National Journal of Maxillofacial Surgery
Anne-Marie Pobloth, Sara Checa, Hajar Razi, Ansgar Petersen, James C Weaver, Katharina Schmidt-Bleek, Markus Windolf, Andras Á Tatai, Claudia P Roth, Klaus-Dieter Schaser, Georg N Duda, Philipp Schwabe
Three-dimensional (3D) titanium-mesh scaffolds offer many advantages over autologous bone grafting for the regeneration of challenging large segmental bone defects. Our study supports the hypothesis that endogenous bone defect regeneration can be promoted by mechanobiologically optimized Ti-mesh scaffolds. Using finite element techniques, two mechanically distinct Ti-mesh scaffolds were designed in a honeycomb-like configuration to minimize stress shielding while ensuring resistance against mechanical failure...
January 10, 2018: Science Translational Medicine
Xi Jiang, Yu Zhang, Ping Di, Ye Lin
BACKGROUND: Guided bone regeneration (GBR) is currently the most widely used technique to reconstruct localized peri-implant bone defects. OBJECTIVES: To evaluate hard tissue volume stability during the healing stage of GBR with particulate bone graft and resorbable collagen membrane. MATERIALS AND METHODS: Twenty-eight patients who were missing a single maxillary incisor and required implant placement combined with GBR were randomly assigned to 2 groups: submerged (n = 14) and transmucosal (n = 14) healing groups...
February 2018: Clinical Implant Dentistry and related Research
Sajedeh Khorshidi, Akbar Karkhaneh
Osteochondral tissue regeneration is a complicated field due to the distinct properties and healing potential of osseous and chondral phases. In a natural osteochondral region, the composition, mechanics and structure vary smoothly from bony to cartilaginous phase. Therefore, a homogeneous scaffold cannot satisfy the complexity of the osteochondral matrix. In essence, a natural extracellular matrix (ECM) is composed of fibrous proteins elongated into a gelatinous background. A hydrogel/fiber scaffold possessing gradient in both phases would be of the utmost interest to imitate tissue arrangement of a native osteochondral interface...
December 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
Y Li, J Zhou, P Pavanram, M A Leeflang, L I Fockaert, B Pouran, N Tümer, K-U Schröder, J M C Mol, H Weinans, H Jahr, A A Zadpoor
An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly challenging. Here we present topologically ordered porous magnesium (WE43) scaffolds based on the diamond unit cell that were fabricated by selective laser melting (SLM) and satisfy all the requirements...
December 11, 2017: Acta Biomaterialia
Niloofar Jenabian, Sina Haghanifar, Hodis Ehsani, Ehsan Zahedi, Masumeh Haghpanah
Background: The treatment of furcation area defects remained as a challenging issue in periodontal treatments. Regeneration treatment of furcation defects is the most discussed periodontal treatment. Although not completely hopeless in prognosis, the presence of the furcation involvement significantly increases the chance of tooth loss. The current research was conductedeto compare theeadditive effect of combined guided tissue regeneration (GTR) and platelet-rich growth factor (PRGF) on the treatment of furcation bony defects...
November 2017: Dental Research Journal
Balamanikandasrinivasan Chandrasekaran, Nanditha Suresh, Senthilkumar Muthusamy
Supernumerary teeth are hyperdontic variants due to abnormalities during tooth development. Here, we report a case on regeneration of bony defect, which ensued following extraction of two supernumerary teeth in the mandibular premolar region, using a combination of bone grafts and platelet-rich fibrin. To the best of our knowledge, it is the first time synergistic use of biomaterials with bone grafts have been used for this type of management.
2017: Chinese Journal of Dental Research
F Pourdanesh, M Esmaeelinejad, F Aghdashi
The reconstruction of severely atrophic ridges is often challenging and complicated. We searched the Medline, Embase, and Cochrane databases for articles up to October 2015 that reported the success of all types of tenting for bony regeneration. We extracted data on the size and site of the defect, the number of patients, vertical and horizontal augmentation, survival of dental implants, and complications. Thirteen studies were included, which yielded data on 423 patients with 1111 dental implants. Follow-up periods were more than five years, severely resorbed mandibles were augmented vertically by up to 10mm, and the survival rate of the implants was over 97%...
December 2017: British Journal of Oral & Maxillofacial Surgery
Mohammad Bayat, Amarjit Virdi, Fatemehalsadat Rezaei, Sufan Chien
To compare the in vitro effectiveness of Low-Level Laser Therapy (LLLT) and Low Intensity Pulsed Ultrasound (LIPUS) on bony cells and related stem cells. In this study, we aim to systematically review the published scientific literature which explores the use of LLLT and LIPUS to biostimulate the activity or the proliferation of bony cells or stem cells in vitro. We searched the database PubMed for LLLT or LIPUS, with/without bone, osteoblast, osteocyte, stem cells, the human osteosarcoma cell line (MG63), bone-forming cells, and cell culture (or in vitro)...
November 8, 2017: Progress in Biophysics and Molecular Biology
Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd, Roman Krawetz
BACKGROUND: p21((WAF1/CIP1/SDI1)), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair. Studies on p21((-/-)) knockout mice have demonstrated results that vary from complete regeneration and healing of tissue to attenuated healing. There have however been no studies that have evaluated the role of p21 inhibition in bone healing and remodeling. METHODS: The current study employs a burr-hole fracture model to investigate bone regeneration subsequent to an injury in a p21(-/-) mouse model...
November 9, 2017: BMC Musculoskeletal Disorders
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