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bony regenerate

Zi-Hui Yang, Bao-Lei Wu, Chen Ye, Sen Jia, Xin-Jie Yang, Rui Hou, De-Lin Lei, Lei Wang
Distraction osteogenesis (DO) is a widely used self-tissue engineering. However, complications and discomfort due to the long treatment period are still the bottleneck of DO. Novel strategies to accelerate bone formation in DO are still needed. P38 is capable of regulating the osteogenic differentiation of both mesenchymal stem cells (MSCs) and osteoblasts, which are crucial to bone regeneration. However, it is not clear whether targeting p38 could regulate bony formation in DO. The purpose of the current work was to investigate the effects of local application of either p38 agonist anisomycin or p38 inhibitor SB203580 in a rat model of DO...
2016: International Journal of Medical Sciences
Shery Park, Hu Zhao, Mark Urata, Yang Chai
Repair of calvarial bony defects remains challenging for craniofacial surgeons. Injury experiments on animal calvarial bones are widely used to study healing mechanisms and test tissue engineering approaches. Previously we identified Gli1+ cells within the calvarial sutures as stem cells supporting calvarial bone turnover and injury repair. In this study, we tested the regenerative capacity of the suture region compared to other areas of calvarial bone. Injuries were made to mouse sagittal sutures or other areas of the calvarial bone at varying distances from the suture...
October 20, 2016: Stem Cells and Development
Nizar Algarni, Michael Grant, Laura M Epure, Omar Salem, Rakan Farouk Bokhari, John Antoniou, Fackson Mwale
Link N (DHLSDNYTLDHDRAIH), is a naturally occurring peptide that can stimulate matrix production in vitro, in vivo and in intact ex vivo human intervertebral discs (IVDs). We have recently discovered that annulus fibrosus cells (AF) cells have the ability to proteolytically process Link N resulting in a fragment spanning amino acid residues 1-8 short Link N (sLink N). Separately, we recently developed and validated a large animal disc organ culture model that maintains long-term cell viability while retaining the bony endplates and vertebral bone (vIVDs; IVD with intact vertebrae)...
September 27, 2016: Tissue Engineering. Part A
Hui Li, Qiuxia Ji, Yan Sun, Quanchen Xu, Wenbin Song, Wei Li, Dandan Li, Panpan Deng, Fang Hu, Jianjun Yang
Regeneration of alveolar bone is among the main purposes of periodontal treatment. However, it is a challenge for both dentists and patients. An injectable chitosan-based thermosensitive hydrogel scaffold (CS/CSn-GP) was successfully designed and prepared with the incorporation of bone morphogenetic protein-2 plasmid DNA (pDNA-BMP2)-loaded chitosan nanoparticles (CS/CSn(pDNA-BMP2)-GP) in this study. The aim of this study was to evaluate the regenerative effect of this scaffold on the endogenous repair of alveolar bone...
September 16, 2016: Journal of Biomedical Materials Research. Part A
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Jae-Sung Park, Ki Hwan Jung, Soo Whan Kim, Jin Hee Cho, Yong Jin Park, Yun Jin Kang, Sung Won Kim
OBJECTIVE: To describe the clinical features of invagination of the sphenoid sinus mucosa (ISM) and compare them with other similar cases using a visual analog scale (VAS) to assess the various nasal symptoms and to discuss its clinical significance and means of prevention. STUDY DESIGN: Retrospective chart review at a tertiary referral center. METHODS: Between 2010 and 2015, 8 patients who had undergone EETSA surgery displayed postoperative ISM...
2016: PloS One
A R Pradeep, Dharmendra Kanoriya, Sandeep Singhal, Vibhuti Garg, C N Guruprasad
BACKGROUND: Platelet-rich fibrin (PRF) is a reservoir of concentrated platelets, provides pool of biologic growth promoting factors and cytokines which helps in mediating regeneration of the lost bone and soft tissue maturation. Alendronate (ALN), member of amino-bisphosphonate group is known to enhance periodontal tissue regeneration by inhibiting osteoclast mediated bone resorption and promoting osteoblast mediated osteogenesis. The current intervention was intended for assessing the combined effectiveness of PRF and 1% ALN with access therapy in intrabony defects treatment in patients with chronic periodontitis...
August 26, 2016: Journal of Periodontology
Chun Yang, Xiao Lu, Hongmei Sun, Wen Hui Chu, Chunyi Li
Deer antlers are the only mammalian appendages that can fully regenerate each year from the permanent bony protuberances of the frontal bones, called pedicles. Pedicle periosteum (PP) is the key tissue for antler regeneration and the source of antler stem cells. The distal one third of the PP has acquired the ability to regenerate antlers and is termed the potentiated PP (PPP), whereas the proximal two thirds of the PP requires further interactions within its niche to launch antler regeneration and is termed the dormant PP (DPP)...
September 2016: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
Matthew Q Miller, Abhijit Dighe, Quanjun Cui, Stephen S Park, J Jared Christophel
The field of regenerative medicine aims at enhancing tissue healing and regeneration through the exogenous addition of therapeutic growth factors and cells, often in combination with tissue-compatible scaffolds. Perhaps the biggest advances in facial plastic and reconstructive surgery (FPRS) in the coming years will be the result of regenerative medicine techniques. While many articles on regenerative medicine have been published in the FPRS literature, to our knowledge there are no reviews that describe both soft-tissue and bony regeneration strategies, including scaffolds, stem cells, growth factors, and platelet-rich plasma...
September 1, 2016: JAMA Facial Plastic Surgery
Karim Z Masrouha, Youssef El-Bitar, Marc Najjar, Said Saghieh
The management of soft tissue defects in tibial fractures is essential for limb preservation. Current techniques are not without complications and may lead to poor functional outcomes. A salvage method is described using three illustrative cases whereby a combination of flaps and antibiotic-impregnated polymethylmethacrylate beads are employed to fill the bony defect, fight the infection, and provide a surface for epithelial regeneration and secondary wound closure. This was performed after the partial failure of all other options...
June 2016: Archives of Bone and Joint Surgery
Shih-Shiun Shyu, Earl Fu, E-Chin Shen
Concentrated growth factors (CGFs) can be used to enhance wound healing. This case report describes a short-term effect of CGF grafting followed by implant placement in a cystic bony defect within the mandible. Healing conditions were monitored by 2 implant-related surgeries, radiographs, and a microcomputed topography examination. Continuous increase of radiopacity in radiographs was noticed till 6 months after grafting. Bone core specimen was taken at 3.5 months after grafting, and percent bone volume reached 32...
October 2016: Implant Dentistry
Rafael Delgado-Ruiz, Georgios E Romanos, Sergio Alexandre Gerhke, Gerardo Gomez-Moreno, José Eduardo Maté-Sánchez de Val, José Luis Calvo-Guirado
OBJECTIVES: To compare different compressive forces exerted on a particulate graft material during socket preservation and their effects on bone regeneration. MATERIAL AND METHODS: Six male dogs were used. The second, third, and fourth premolars, and the first molar were extracted bilaterally at the lower jaws. A particulate synthetic biphasic grafting material (60% HA and 40% β-tricalcium phosphate) was used. Three different standardized compressive forces were applied randomly during the socket preservation...
August 2, 2016: Clinical Oral Implants Research
Woon Hyeok Jeong, Tai Suk Roh, Young Seok Kim, Eun Hye Kang, Bok Ki Jung, Won Jai Lee, Dae Hyun Lew, In Sik Yun
PURPOSE: The effects of platelet-rich plasma (PRP) on improvement of bone regeneration have been widely investigated. However, use of a proper scaffold is also important to the delivery of bioactive materials. The aim of this study was to analyze the effects of PRP with acellular dermal matrix (ADM) as a bone substitute in a cranial defect model. METHODS: Twenty-nine New Zealand white rabbits were randomly divided into four groups including control, PRP, ADM, and PRP with ADM...
September 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Ansgar C Hergt, Benedicta E Beck-Broichsitter, Jan Raethjen, Nathalie Käser, Michael Hülsmann, Jörg Wiltfang, Jörg Heine, Stephan T Becker
PURPOSE: The aim of this study was to examine the in situ regeneration of the inferior alveolar nerve (IAN) in its bony channel, using autologous tissue in combination with a recombinant human nerve growth factor (rhNGF). MATERIALS AND METHODS: A total of 20 New Zealand rabbits were randomly divided into five groups. Following dissection of the IAN, the animals underwent reconstruction either with muscle tissue (groups 1 and 2) or with fat tissue (groups 3 and 4)...
September 2016: Journal of Cranio-maxillo-facial Surgery
Melanie Haffner-Luntzer, Julia Kemmler, Verena Heidler, Katja Prystaz, Thorsten Schinke, Michael Amling, Anna Kovtun, Anna E Rapp, Anita Ignatius, Astrid Liedert
The heparin-binding growth and differentiation factor midkine (Mdk) is proposed to negatively regulate osteoblast activity and bone formation in the adult skeleton. As Mdk-deficient mice were protected from ovariectomy (OVX)-induced bone loss, this factor may also play a role in the pathogenesis of postmenopausal osteoporosis. We have previously demonstrated that Mdk negatively influences bone regeneration during fracture healing. Here, we investigated whether the inhibition of Mdk using an Mdk-antibody (Mdk-Ab) improves compromised bone healing in osteoporotic OVX-mice...
2016: PloS One
Shuai Liu, Yue Sun, Yu Fu, Datong Chang, Cuicui Fu, Gaonan Wang, Yan Liu, Franklin R Tay, Yanheng Zhou
INTRODUCTION: Natural bone has a complex hierarchical nanostructure composed of well-organized collagen fibrils embedded with apatite crystallites. Bone tissue engineering requires scaffolds with structural properties and functionality similar to the natural bone. Inspired by bone, a collagen-apatite (Col-Ap) nanocomposite was fabricated with bonelike subfibrillar nanostructures using a modified bottom-up biomimetic approach and has a potential role in the healing of large bone defects in unresolved apical periodontitis...
August 2016: Journal of Endodontics
Gokhan Gurler, Cagri Delilbasi
BACKGROUND: Blood products have been widely used in soft tissue and bone regeneration in oral and maxillofacial surgery. The purpose of this study is to evaluate the effects of leukocyte-platelet rich fibrin (L-PRF) following direct sinus lifting procedure. METHODS: Twenty-eight patients were included in the study. Direct sinus lifting was performed via lateral window approach under conscious sedation and local anesthesia. Bony window and sinus floor elevation were performed using piezosurgery device...
August 2016: Minerva Stomatologica
J Malmström, J Anderud, P Abrahamsson, D-Å Wälivaara, S G Isaksson, E Adolfsson
Guided bone regeneration (GBR) describes the use of membranes to regenerate bony defects. A membrane for GBR needs to be biocompatible, cell-occlusive, non-toxic, and mouldable, and possess space-maintaining properties including stability. The purpose of this pilot study was to describe a new method of GBR using individualized ceramic sheets to perfect bone regeneration prior to implant placement; bone regeneration was assessed using traditional histology and three-dimensional (3D) volumetric changes in the bone and soft tissue...
October 2016: International Journal of Oral and Maxillofacial Surgery
F Amerstorfer, S F Fischerauer, L Fischer, J Eichler, J Draxler, A Zitek, M Meischel, E Martinelli, T Kraus, S Hann, S E Stanzl-Tschegg, P J Uggowitzer, J F Löffler, A M Weinberg, T Prohaska
UNLABELLED: We report on the long-term effects of degrading magnesium implants on bone tissue in a growing rat skeleton using continuous in vivo micro-Computed Tomography, histological staining and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Two different magnesium alloys-one rapidly degrading (ZX50) and one slowly degrading (WZ21)-were used to evaluate the bone response and distribution of released Mg and Y ions in the femur of male Sprague-Dawley rats. Regardless of whether the alloy degrades rapidly or slowly, we found that bone recovers restitutio ad integrum after complete degradation of the magnesium implant...
September 15, 2016: Acta Biomaterialia
Santosh S Martande, Minal Kumari, A R Pradeep, Sonender Pal Singh, Deepak Kumar Suke, C N Guruprasad
BACKGROUND: Platelet-rich fibrin (PRF), a second-generation platelet concentrate, and atorvastatin (ATV), a potent member of the statin group, are known to promote tissue regeneration. The current study is designed to evaluate combined efficacy of PRF and 1.2% ATV gel with open flap debridement (OFD) in treatment of intrabony defects (IBDs) in individuals with chronic periodontitis (CP). METHODS: Ninety-six individuals with single defects were categorized into three groups: 1) OFD with PRF; 2) OFD with PRF + 1...
September 2016: Journal of Periodontology
Dhong Won Lee, Jin Goo Kim, Jeong Ku Ha, Woo Jong Kim
The optimal treatment for combined osteochondritis dissecans (OCD) with considerable bony defect of the lateral femoral condyle (LFC) and torn discoid lateral meniscus is unclear. We present a case of a 15-year-old female who was a gymnast and had a large OCD lesion in the LFC combined with deficiency of the lateral meniscus. The patient underwent the "one-step" technique of osteoperiosteal autologous iliac crest graft and lateral meniscus allograft transplantation after a failure of meniscectomy with repair at another hospital...
June 2016: Knee Surgery & related Research
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