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https://www.readbyqxmd.com/read/29155657/frontline-field-epidemiology-training-programs-as-a-strategy-to-improve-disease-surveillance-and-response
#1
A McKenzie André, Augusto Lopez, Samantha Perkins, Stephanie Lambert, Lesley Chace, Nestor Noudeke, Aissatou Fall, Biagio Pedalino
Since 1980, Field Epidemiology Training Programs (FETPs) have trained highly qualified field epidemiologists to work for ministries of health (MOH) around the world. However, the 2013-2015 Ebola epidemic in West Africa, which primarily affected Guinea, Liberia, and Sierra Leone, demonstrated a lack of field epidemiologists at the local levels. Trained epidemiologists at these levels could have detected the Ebola outbreak earlier. In 2015, the US Centers for Disease Control and Prevention (CDC) launched FETP-Frontline, a 3-month field training program targeting local MOH staff in 24 countries to augment local public health capacity...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29145018/nitrogen-phosphorus-dual-doped-molybdenum-carbide-molybdenum-phosphide-carbon-nanospheres-for-efficient-hydrogen-evolution-over-the-whole-ph-range
#2
Jing-Qi Chi, Wen-Kun Gao, Jia-Hui Lin, Bin Dong, Kai-Li Yan, Jun-Feng Qin, Zi-Zhang Liu, Yong-Ming Chai, Chen-Guang Liu
MoO4(2-)@aniline-pyrrole (MoO4(2-)@polymer) spheres as precursors have been used to synthesize unique core-shell nanostructure consisting of molybdenum carbide and molybdenum phosphide composites encapsulated into uniformly dual N, P-doped carbon shells (Mo2C/MoP@NPC) through a facile two-step strategy. Firstly, porous core-shell N-doped Mo2C@C (Mo2C@NC) nanospheres have been synthesized with ultrafine Mo2C nanoparticles as core and ultrathin NC as shell by a annealing route. Secondly, Mo2C/MoP@NPC has been obtained maintaining intact spherical-like morphology through a phosphidation reaction in high temperature...
November 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29141712/clinical-outcomes-during-treatment-interruptions-in-human-immunodeficiency-virus-hepatitis-b-virus-co-infected-patients-from-sub-saharan-africa
#3
Anders Boyd, Laura Houghtaling, Raoul Moh, Mariama Abdou Chekaraou, Delphine Gabillard, Serge Paul Eholié, Xavier Anglaret, Fabien Zoulim, Christine Danel, Karine Lacombe, For The Anrs Trivacan And Anrs VarBVA Studies
Antiretroviral treatment (ART) interruptions increase the risk of severe morbidity/mortality in human immunodeficiency virus (HIV)-infected individuals from subSaharan Africa. We aimed to determine whether the risk is further increased among HIV-hepatitis B virus (HBV) co-infected patients in this setting. In this sub-analysis of a randomized-control trial, 632 participants from Côte d'Ivoire randomized to receive continuous-ART (C-ART), structured ART interruptions of 2-months off, 4-months on (2/4-ART), and CD4-guided ART interruptions (CD4GT, interruption at 350/mm(3) and reintroduction at 250/mm(3)) were analyzed...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140870/a-retrospective-assessment-of-postoperative-bleeding-complications-in-anticoagulated-patients-following-mohs-micrographic-surgery
#4
Robert E Eilers, Alina Goldenberg, Natasha L Cowan, Pallavi Basu, Shang I Brian Jiang
BACKGROUND: A significant number of patients undergoing Mohs micrographic surgery (MMS) for skin cancer are treated with oral anticoagulants. The incidence of postoperative complications associated with new classes of oral anticoagulants remains largely unknown. OBJECTIVE: To determine the incidence of postoperative complications in patients undergoing MMS on both traditional oral anticoagulants and new novel oral anticoagulants. MATERIALS AND METHODS: A single-center retrospective chart review was performed for all patients treated with oral anticoagulants who underwent MMS between July 1, 2012 and June 30, 2015 at University of California, San Diego...
November 14, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29140864/bupivacaine-as-an-adjunct-to-lidocaine-in-mohs-micrographic-surgery-a-prospective-randomized-controlled-trial
#5
Peggy Chen, Harvey Smith, Carl Vinciullo
BACKGROUND: In Mohs micrographic surgery (MMS), the standard local anesthetic agent used is lignocaine with adrenaline. However, MMS can be prolonged; thus reinjections of local anesthetics are often required. OBJECTIVE: Is 0.5% bupivacaine with 1:200,000 epinephrine a useful adjunctive treatment when compared with the use of 1% lidocaine with 1:100,000 epinephrine in MMS for the nose? METHODS: Participants undergoing MMS received 2.5 mL of 1% lidocaine with 1:100,000 epinephrine before commencement of Stage 1...
November 14, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29140863/practice-patterns-and-job-satisfaction-of-mohs-surgeons
#6
Nita Kohli, Nicholas Golda
BACKGROUND: There is a paucity of data on Mohs surgery workforce patterns. OBJECTIVE: To identify if gender differences exist in practice patterns of Mohs surgeons, factors that influence these differences, and factors influencing job satisfaction among Mohs surgeons. MATERIALS AND METHODS: An electronic survey was distributed to dermatology organizations targeting members of the American College of Mohs Surgery (ACMS), from October 2015 to April 2016...
November 14, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29121782/imaging-in-cutaneous-surgery
#7
Amanda Levine, Daniel Siegel, Orit Markowitz
Skin cancer is the most commonly diagnosed cancer in the USA. Mohs micrographic surgery is a microscopically controlled surgical technique that excises lateral and deep surgical margins while also sparing function and achieving a good cosmetic outcome. Given the increasing incidence in skin cancer worldwide and its associated treatment costs, techniques are being developed to improve the time and cost efficacy of this procedure. The use of noninvasive imaging, both in vivo and ex vivo, has the potential to increase efficiency of diagnosis and surgical management of skin cancers...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29112529/factors-influencing-squamous-cell-carcinoma-in-situ-recurrence-and-implications-for-treatment-choice
#8
Andrew J Matsumoto, Adam R Schmitt, Logan M Skelley, Christian L Baum
BACKGROUND: Numerous treatment modalities have been reported for squamous cell carcinoma in situ (SCCIS). Risk factors for recurrence have not been systematically reviewed. OBJECTIVE: To systematically review and summarize the data on risk factors that contribute to recurrence of SCCIS. MATERIALS AND METHODS: A PubMed search was completed using the terms "SCCIS," "Bowen's disease," "Bowen's disease and recurrence," and "Bowen's disease and Mohs...
November 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29112526/staffing-metrics-in-mohs-surgery
#9
Imelda R Muller, David K Chen, Glenn D Goldman
No abstract text is available yet for this article.
November 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29101861/clinical-characteristics-and-overuse-patterns-of-medication-overuse-headache-retrospective-case-series-study
#10
Karolis Kluonaitis, Elena Petrauskiene, Kristina Ryliskiene
According to Eurolight project's results, frequency of medication overuse headache in Lithuania is similar to other European countries. However, data on the characteristics of the disorder is lacking. OBJECTIVE: The aim was to analyze clinical characteristics and overuse patterns of patients with medication overuse headache. PATIENTS AND METHODS: Retrospective study was conducted in out-patient department of university hospital. 57.0% of the patients were from Vilnius and 43...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29097944/multimodal-imaging-nanoparticles-derived-from-hyaluronic-acid-for-integrated-preoperative-and-intraoperative-cancer-imaging
#11
William M Payne, Tanner K Hill, Denis Svechkarev, Megan B Holmes, Balasrinivasa R Sajja, Aaron M Mohs
Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29095130/comparability-of-mineral-oil-testing-for-dry-food-and-cardboard-samples-perspectives-from-different-pt-rounds
#12
Milena Funk, Hedda Hillmann, Ralph Derra, Ulrich Leist
Mineral oil hydrocarbons (MOH) can be found in detectable levels in a multitude of foodstuffs. Therefore, chemical analysis of food for MOH gains importance. Different proficiency testing (PT) rounds on mineral oil testing have been performed in different matrices: cereals and rice as well as cardboard samples were examined. The laboratories participating in the PT rounds had to follow specific requirements for examination. The sample materials used contained different concentrations of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH)...
November 14, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29093628/evidence-from-a-familial-case-suggests-maternal-inheritance-of-primary-biliary-cholangitis
#13
Saeam Shin, In Ho Moh, Young Sik Woo, Sung Won Jung, Jin Bae Kim, Ji Won Park, Ki Tae Suk, Hyoung Su Kim, Mineui Hong, Sang Hoon Park, Myung Seok Lee
Primary biliary cholangitis (PBC) is an idiopathic autoimmune liver disease characterized by chronic cholestasis and destruction of the intrahepatic bile ducts. Similar to other autoimmune diseases, the pathogenesis of PBC is considered to be a complex etiologic phenomenon involving the interaction of genetic and environmental factors. Although a number of common variants associated with PBC have been reported from genome-wide association studies, a precise genetic mechanism underlying PBC has yet to be identified...
October 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29073988/drug-policy-in-bulgaria
#14
Antoniya Dimova, Maria Rohova, Elka Atanasova, Paweł Kawalec, Katarzyna Czok
Bulgaria has a mixed public-private health care financing system. Health care is financed mainly from compulsory health insurance contributions and out-of-pocket payments. Out-of-pocket payments constitute a large share of the total health care expenditure (44.14% in 2014). The share of drugs expenditure for outpatient treatment was 42.3% of the total health care expenditure in 2014, covered mainly by private payments (78.6% of the total pharmaceutical expenditure). The drug policy is run by the Ministry of Health (MoH), the National Council on Prices and Reimbursement of Medicinal Products, and the Health Technology Assessment Commission...
September 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29072886/rapid-field-response-to-a-cluster-of-illnesses-and-deaths-sinoe-county-liberia-april-may-2017
#15
John Doedeh, Joseph Asamoah Frimpong, Kwuakuan D M Yealue, Himiede W Wilson, Youhn Konway, Samson Q Wiah, Vivian Doedeh, Umaru Bao, George Seneh, Lawrence Gorwor, Sylvester Toe, Emmanuel Ghartey, Lawrence Larway, Dedesco Gweh, Philemon Gonotee, Thomas Paasewe, George Tamatai, James Yarkeh, Samuel Smith, Annette Brima-Davis, George Dauda, Thomas Monger, Leleh W Gornor-Pewu, Siafa Lombeh, Jeremias Naiene, Nathaniel Dovillie, Mark Korvayan, Geraldine George, Garrison Kerwillain, Ralph Jetoh, Suzanne Friesen, Carl Kinkade, Victoria Katawera, Maame Amo-Addae, Roseline N George, Miatta Z Gbanya, E Kainne Dokubo
On April 25, 2017, the Sinoe County Health Team (CHT) notified the Liberia Ministry of Health (MoH) and the National Public Health Institute of Liberia of an unknown illness among 14 persons that resulted in eight deaths in Sinoe County. On April 26, the National Rapid Response Team and epidemiologists from CDC, the World Health Organization (WHO) and the African Field Epidemiology Network (AFENET) in Liberia were deployed to support the county-led response. Measures were immediately implemented to identify all cases, ascertain the cause of illness, and control the outbreak...
October 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29068229/direct-observation-of-a-photochemical-alkyne-allene-reaction-and-of-a-twisted-and-rehybridized-intramolecular-charge-transfer-state-in-a-donor-acceptor-dyad
#16
Bogdan Dereka, Denis Svechkarev, Arnulf Rosspeintner, Maximilian Tromayer, Robert Liska, Aaron M Mohs, Eric Vauthey
The excited-state dynamics of an aniline-triazine electron donor-acceptor dyad with an alkyne spacer has been investigated using a combination of ultrafast broadband mid-IR and visible transient absorption and fluorescence spectroscopies. The transient IR data reveal the occurrence of an efficient alkyne to allene isomerization of the spacer with a time constant increasing from a few hundreds of femtoseconds to a few picoseconds with solvent viscosity. This process is faster than the vibrational cooling of the Franck-Condon excited state, indicative of nonequilibrium dynamics...
November 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29068228/palladium-catalyzed-removable-8-aminoquinoline-assisted-chemo-and-regioselective-oxidative-sp-2-c-h-sp-3-c-h-cross-coupling-of-ferrocene-with-toluene-derivatives
#17
Moh Sattar, Sangit Kumar
The coupling of the C(sp(2))-H bond of ferrocene with toluene avoiding in situ functionalization of both coupling partners has been achieved using palladium and iron dual catalysis. This cross oxidative coupling features regioselectivity to primary and secondary C(sp(3))-H bonds and chemoselectivity toward the -C(sp(3))-H over C-I bond of toluene with gram-scale production. It seems Fe(II) catalyst not only stabilizes the generated benzyl radical but also tames its oxidizing behavior, and consequently transfers it to the palladacycle for C-C coupling...
October 25, 2017: Organic Letters
https://www.readbyqxmd.com/read/29066694/-clinical-evaluation-of-indoleamine-2-3-dioxygenase-in-the-serum-of-patients-with-locally-advanced-breast-cancer-during-mohs-paste-treatment
#18
Hitomi Kubota, Kenichi Sakurai, Shigeru Fujisaki, Yukiko Hara, Shuhei Suzuki, Keita Adachi, Ryouichi Tomita, Katsuhisa Enomoto, Tomohiro Hirano, Reina Saga, Makoto Makishima
Locally advanced breast cancer lesions often compromise patients' quality of life(QOL). Mohs paste is a histopathological fixative with zinc chloride as the main ingredient. It is applied when performing chemosurgery for skin tumors. In recent years, this paste has reportedly been very effective for the control of various symptoms of skin metastases in inoperable advanced cancers, such as pungent odor and hemorrhage, in the field of palliative care. We evaluated the clinical significance of indoleamine 2, 3-dioxygenase(IDO)in the serum of patients with locally advanced breast cancer during Mohs paste treatment...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066323/correlation-between-incisional-biopsy-histological-subtype-and-a-mohs-surgery-specimen-for-nonmelanoma-skin-cancer
#19
E C Cortés-Peralta, J Ocampo-Candiani, O T Vázquez-Martínez, I M Gutiérrez-Villarreal, I Miranda-Maldonado, V Garza-Rodríguez
BACKGROUND: Histological diagnosis of a clinically suspected nonmelanoma skin cancer (NMSC) is recommended before treatment. For NMSC, concordance between the histological subtype of the preoperative biopsy and the excision specimen of basal cell carcinoma (BCC) has been reported to range from 10% to 81%. No large study on the concordance between NMSC histology seen in a preoperative biopsy with the following tumour specimen from Mohs micrographic surgery (MMS) has been performed in a Latin American population...
October 21, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29064089/high-risk-squamous-cell-carcinoma-masquerading-as-dense-inflammation-on-mohs-frozen-sections
#20
Liang Joo Leow
High-risk squamous cell carcinoma (SCC) can present a unique challenge in Mohs surgery. This case report describes how high-risk SCC may masquerade as only a dense inflammation on frozen sections. This feature should raise the index of suspicion for hidden SCC and be a routine indication for further processing by paraffin sections and immunohistochemistry.
October 24, 2017: Australasian Journal of Dermatology
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