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https://www.readbyqxmd.com/read/28214180/a-successful-experience-of-the-iranian-blood-transfusion-organization-in-improving-accessibility-and-affordability-of-plasma-derived-medicine
#1
REVIEW
Azita Chegini, Seyed Ardeshir Torab, Ali Akbar Pourfatollah
Plasma is the liquid part of blood. It is estimated 21.6 million liters of plasma collect from Whole blood annually. From these plasma, 4.2 million liters transfuse, 8.1 million liters fractionate, 9.3 million liters waste. Nowadays, blood products and PDM (plasma derived medicine) consider as essential medicine in modern health care and transfusion medicine. Iranian blood transfusion organization as a non-profit organization was established in 1974 in order to centralize all blood transfusion activities from donor recruitment to distribution of blood components to hospitals...
January 4, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28199474/implementation-of-fluorescence-confocal-mosaicking-microscopy-by-early-adopter-mohs-surgeons-and-dermatologists-recent-progress
#2
Manu Jain, Milind Rajadhyaksha, Kishwer Nehal
No abstract text is available yet for this article.
February 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28195847/trends-in-the-mohs-surgery-literature-1994-2013
#3
Ruben Kershenovich, Lihi Atzmony, Ofer Reiter, Moshe Lapidoth, Daniel Mimouni, Moshe Lapidoth, Daniel Mimouni
No abstract text is available yet for this article.
February 9, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28195845/an-analysis-of-laser-therapy-for-the-treatment-of-nonmelanoma-skin-cancer
#4
Teo Soleymani, Michael Abrouk, Kristen M Kelly
BACKGROUND: Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar. OBJECTIVE: Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option...
February 9, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28181812/transition-metal-free-selective-oxidative-c-sp-3-s-se-coupling-of-oxindoles-tetralone-and-arylacetamides-synthesis-of-unsymmetrical-organochalcogenides
#5
Ch Durga Prasad, Moh Sattar, Sangit Kumar
Transition-metal-free synthetic methods have been developed for the preparation of unsymmetrical diaryl and aryl alkyl chalcogenides: sulfones, sulfides, and selenides from the sp(3)-C-H bond of oxindole, tetralone, arylacetamide, and aryl chalcogenide precursors. Sulfones were obtained from sodium sulfinates using potassium iodide, tert-butyl hydroperoxide in DMSO, and acetic acid. Sulfides and selenides were prepared from diaryl disulfides or diselenides employing potassium tert-butoxide in DMSO. α-Tetralone underwent concomitant chalcogenation and aromatization resulting in 2-chalcogenyl-1-naphthols in one pot...
February 9, 2017: Organic Letters
https://www.readbyqxmd.com/read/28181233/sebaceous-carcinoma-in-solid-organ-transplant-recipients
#6
Elika Hoss, Steven A Nelson, Amit Sharma
BACKGROUND: Though a rare tumor, sebaceous carcinoma is relatively well-described in immunocompetent patients, in whom it often occurs in a periorbital distribution where it has an overall poor prognosis with a high metastasis rate. The effect of transplant-related immunosuppression on the development of sebaceous carcinoma and its outcomes has not been characterized. METHODS: We collected 9 cases from a single institution of patients developing sebaceous carcinoma after solid organ transplantation...
February 8, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28178008/processing-adipose-rich-mohs-samples-a-comparative-study-of-effectiveness-of-pretreatment-with-liquid-nitrogen-versus-flash-freezing-spray
#7
Jeave Reserva, Zachary Kozel, Cindy Krol, Jodi Speiser, William Adams, Rebecca Tung
Processing of adipose-rich Mohs micrographic surgery (MMS) specimens poses challenges that may preclude complete margin evaluation. In this setting, the value of additional freezing methods using various cooling agents has not been previously investigated. The aim of this study is to compare the frozen section quality of high-adipose Mohs specimens processed without additional cooling treatments versus those pretreated with 1,1,1,2-tetrafluoroethane (TFE) or liquid nitrogen (LN2). A set of 3 sections were each taken from 24 adipose-rich Mohs micrographic surgery specimens...
January 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28178005/surgical-treatment-and-outcomes-of-patients-with-extramammary-paget-disease-a-cohort-study
#8
Sharon J Kim, Agnieszka K Thompson, Adeel S Zubair, Clark C Otley, Christopher J Arpey, Christian L Baum, Randall K Roenigk, Christine M Lohse, Jerry D Brewer
BACKGROUND: Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option. OBJECTIVE: To compare long-term outcomes after treatment with MMS or excision for primary EMPD. METHODS AND MATERIALS: Retrospective cohort review was conducted for 207 patients with EMPD treated at Mayo Clinic in Rochester, MN, between 1961 and 2012...
February 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28169505/tm-free-chemoselective-oxidative-c-c-coupling-of-sp3-c-h-bond-of-oxindoles-with-arenes-and-addition-to-alkene-synthesis-of-3-aryl-oxindoles-benzofuro-and-indolo-indoles
#9
Sangit Kumar, Moh Sattar, Vandana Rathore, Ch Durga Prasad
A transition-metal (TM) and halogen free NaOtBu-mediated oxidative cross coupling between sp3 C-H bond of oxindoles and sp2 C-H bond of nitroarenes has been developed to access 3-aryl substituted and 3,3-aryldisubstituted oxindoles in DMSO at room temperature in short time. Interestingly, sp3 C-H bond of oxindoles has also been added to styrene under TM-free conditions for the practical synthesis of quaternary 3,3-disubstituted oxindoles. Synthesized 3-oxindoles have also been further transformed into advanced heterocycles; benzofuroindoles, indoloindoles, and substituted indoles...
February 7, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28165350/sebaceous-carcinoma-treated-with-mohs-micrographic-surgery
#10
Kimberly L Brady, Eva A Hurst
BACKGROUND: Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality. OBJECTIVE: To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches. PATIENTS AND METHODS/MATERIALS: Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28160280/medication-overuse-headache-pathophysiological-insights-from-structural-and-functional-brain-mri-research
#11
Todd J Schwedt, Catherine D Chong
BACKGROUND: Research imaging of brain structure and function has helped to elucidate the pathophysiology of medication overuse headache (MOH). METHODS: This is a narrative review of imaging research studies that have investigated brain structural and functional alterations associated with MOH. Studies included in this review have investigated abnormal structure and function of pain processing regions in people with MOH, functional patterns that might predispose individuals to development of MOH, similarity of brain functional patterns in patients with MOH to those found in people with addiction, brain structure that could predict headache improvement following discontinuation of the overused medication, and changes in brain structure and function after discontinuation of medication overuse...
February 3, 2017: Headache
https://www.readbyqxmd.com/read/28155029/texture-features-of-periaqueductal-gray-in-the-patients-with-medication-overuse-headache
#12
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: Periaqueductal gray (PAG) is the descending pain modulatory center, and PAG dysfunction had been recognized in migraine. Here we propose to investigate altered PAG texture features (quantitative approach for extracting texture descriptors for images) in the patients with medication-overuse headache (MOH) based on high resolution brain structural image to understand the MOH pathogenesis. METHODS: The brain structural images were obtained from 32 normal controls (NC) and 44 MOH patients on 3...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28147433/cost-effectiveness-of-aftercare-services-for-people-with-severe-mental-disorders-an-analysis-parallel-to-a-randomised-controlled-clinical-trial-in-iran
#13
Maziar Moradi-Lakeh, Mohsen Yaghoubi, Ahmad Hajebi, Seyed Kazem Malakouti, Mohamad Ghadiri Vasfi
Aftercare services are not part of the usual care for people with severe mental disorders in Iran. This study was performed to assess the cost-effectiveness of aftercare services, including telephone follow-up or home visit, in addition to caregivers' education and training of social skills, for all subjects during the 20 months after hospital discharge. An economic evaluation was performed along with a registered randomised controlled trial (IRCT201009052557N2) on two groups of 60 persons recruited between 2010 and 2012...
February 1, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28144808/volume-gain-of-periaqueductal-gray-in-medication-overuse-headache
#14
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: Periaqueductal gray (PAG) is a substantial descending pain modulatory center, and previous voxel-based morphometry study confirmed the clusters with increased volume in PAG region in medication-overuse headache (MOH). The aim of this study is to investigate altered PAG volume in MOH using an automated PAG segment method to measure the true PAG volume. METHODS: High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 22 patients with MOH and 22 normal controls (NC)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28139264/clinical-and-pathologic-factors-associated-with-subclinical-spread-of-invasive-melanoma
#15
Thuzar M Shin, Waqas R Shaikh, Jeremy R Etzkorn, Joseph F Sobanko, David J Margolis, Joel M Gelfand, Emily Y Chu, Rosalie Elenitsas, Christopher J Miller
BACKGROUND: Indications to treat invasive melanoma with Mohs micrographic surgery (MMS) or analogous techniques with exhaustive microscopic margin assessment have not been defined. OBJECTIVE: Identify clinical and histologic factors associated with subclinical spread of invasive melanoma. METHODS: This retrospective, cross-sectional study evaluated 216 invasive melanomas treated with MMS and melanoma antigen recognized by T cells 1 immunostaining...
January 28, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28135752/-vismodegib-therapy-for-periocular-basal-cell-carcinoma
#16
M Keserü, S Green, S Dulz
Background Basal cell carcinoma (BCC) is the commonest periorbital tumour. Mohs' micrographic surgery and secondary reconstruction is the therapeutic gold standard for periorbital BCC. In cases of inoperability for any reason, therapeutic alternatives are needed. Since the approval of vismodegib, an orally administered, targeted BCC therapy is available. Nevertheless there is little information on the use of vismodegib for periorbital BCC. Patients and Methods In a retrospective study, we analysed the data of 4 patients treated with vismodegib since 2014...
January 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28135340/transcriptome-analysis-and-differential-gene-expression-on-the-testis-of-orange-mud-crab-scylla-olivacea-during-sexual-maturation
#17
Khor Waiho, Hanafiah Fazhan, Md Sheriff Shahreza, Julia Hwei Zhong Moh, Shaibani Noorbaiduri, Li Lian Wong, Saranya Sinnasamy, Mhd Ikhwanuddin
Adequate genetic information is essential for sustainable crustacean fisheries and aquaculture management. The commercially important orange mud crab, Scylla olivacea, is prevalent in Southeast Asia region and is highly sought after. Although it is a suitable aquaculture candidate, full domestication of this species is hampered by the lack of knowledge about the sexual maturation process and the molecular mechanisms behind it, especially in males. To date, data on its whole genome is yet to be reported for S...
2017: PloS One
https://www.readbyqxmd.com/read/28133054/-a-case-report-of-continuous-bleeding-due-to-severe-skin-metastases-of-breast-cancer-successfully-treated-using-mohs-paste
#18
Eigo Satoh, Shingo Ono, Daisuke Uehira, Ayano Murakata, Kazuo Motoyama, Hideo Tanami, Tomomi Iwasaki, Shouji Maruyama, Norihide Sugano, Jun Matsumoto, Takaaki Sakoma
We report a case of severe skin metastases of advanced right breast cancer in an 84-year-old woman. The tumor (T4bN3cM0, Stage III C)was resected in June 2011(BT+AX)after blood transfusion for severe anemia. Radiotherapy to the right chest wall and supraclavicular lymph nodes was performed, and adjuvant hormonal therapy was administered. Local recurrences in the skin of the right chest wall appeared and were resected in December 2011. Nine months later, continuous bleeding from the progressed, widespread skin metastases needed recurrent blood transfusion...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28132035/sclerosing-microcystic-adnexal-carcinoma-of-the-scalp-case-report
#19
U Wollina, J Schönlebe
Microcystic adnexal carcinoma is a rare malignant sweat gland tumor. We present the case report of a 63 year old male patient who developed this malignancy on the scalp, which is an uncommon site. The tumor has been removed by delayed MOHS technique with no relapse. The differential diagnoses and treatment options are discussed.
December 2016: Georgian Medical News
https://www.readbyqxmd.com/read/28130559/basal-cell-carcinoma-arising-in-a-breast-augmentation-scar
#20
Lisa R Edwards, Nicole D Cresce, Mark A Russell
We report a case of a 46-year-old female who presented with a persistent lesion on the inferior right breast. The lesion was located within the scar from a breast augmentation procedure 12 years ago. The lesion had been treated as several conditions with no improvement. Biopsy revealed a superficial and nodular basal cell carcinoma, and the lesion was successfully removed with Mohs micrographic surgery. Basal cell carcinoma arising in a surgical scar is exceedingly rare with only 13 reported cases to date...
January 27, 2017: Aesthetic Plastic Surgery
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