Zhenhua Zhong, Xiaolong Fu, He Li, Jie Chen, Maohua Wang, Song Gao, Liyan Zhang, Cheng Cheng, Yuan Zhang, Peipei Li, Shasha Zhang, Xiaoyun Qian, Yilai Shu, Renjie Chai, Xia Gao
Aminoglycoside-induced hair cell (HC) loss is one of the most important causes of hearing loss. After entering the inner ear, aminoglycosides induce the production of high levels of reactive oxygen species (ROS) that subsequently activate apoptosis in HCs. Citicoline, a nucleoside derivative, plays a therapeutic role in central nervous system injury and in neurodegenerative disease models, including addictive disorders, stroke, head trauma, and cognitive impairment in the elderly, and has been widely used in the clinic as an FDA approved drug...
2020: Frontiers in Cell and Developmental Biology