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Rhinosinusitis

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https://www.readbyqxmd.com/read/29676185/blood-eosinophil-and-basophil-values-before-and-after-surgery-for-eosinophilic-type-sinonasal-polyps
#1
Giuseppe Brescia, Daniela Parrino, Claudia Zanotti, Giulia Tealdo, Umberto Barion, Paolo Sfriso, Gino Marioni
Background Blood eosinophil and basophil levels have recently been considered for the purpose of endotyping chronic rhinosinusitis with nasal polyps (CRSwNP). Histologically, eosinophilic-type CRSwNPs have been associated with high recurrence rates after treatment. Objective The present study was the first to compare blood eosinophil and basophil counts in eosinophilic-type CRSwNP patients before and after endoscopic sinus surgery. Methods The study concerned 79 consecutive patients with histologically confirmed eosinophilic-type CRSwNP treated with endoscopic sinus surgery...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29670184/wogonin-attenuates-nasal-polyp-formation-by-inducing-eosinophil-apoptosis-through-hif-1%C3%AE-and-survivin-suppression
#2
Roza Khalmuratova, Mingyu Lee, Ji-Hun Mo, YunJae Jung, Jong-Wan Park, Hyun-Woo Shin
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is an inflammatory sinonasal disorder characterized by eosinophilic inflammation and T-helper 2 skewing. Eosinophil accumulation in sinonasal mucosa comprises a major feature of CRSwNP. The study aimed to investigate the effect of the flavone wogonin in nasal polyposis by assessing its ability to induce eosinophil apoptosis in vitro and attenuate eosinophilic CRSwNP in mice. Double immunofluorescence, immunohistochemistry, flow cytometry, and immunoblotting were performed to evaluate hypoxia-inducible factor (HIF)-1α, survivin, and apoptotic markers in the human eosinophilic EoL-1 cell line or sinonasal tissues from patients with CRS with or without NPs...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666610/fungi-induced-upper-and-lower-respiratory-tract-allergic-diseases-one-entity
#3
Aleksandra Barac, David S Y Ong, Ljiljana Jovancevic, Aleksandar Peric, Pavol Surda, Vesna Tomic Spiric, Salvatore Rubino
Introduction: Aspergillus can cause different allergic diseases including allergic bronchopulmonary aspergillosis (ABPA) and allergic fungal rhinosinusitis (AFRS). ABPA is allergic pulmonary disease against Aspergillus antigens. AFRS is a type of chronic rhinosinusitis (CRS) presented as hypersensitivity reactions to the fungal presence in sinuses. The aim of the present study was to clarify if ABPA and AFRS could be considered as a common disease entity. Methodology: The prospective cohort study included 75 patients with ABPA...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29665880/post-operative-course-prediction-during-endoscopic-sinus-surgery-in-patients-with-chronic-rhinosinusitis
#4
K Tsuzuki, K Hashimoto, K Okazaki, M Sakagami
OBJECTIVE: This study aimed to analyse findings of functional endoscopic sinus surgery to estimate the post-operative course of patients with chronic rhinosinusitis. METHODS: From 2007 to 2015, 291 adult patients with bilateral chronic rhinosinusitis, divided into eosinophilic chronic rhinosinusitis (n = 210) and non-eosinophilic chronic rhinosinusitis (n = 81) groups, who underwent primary functional endoscopic sinus surgery were enrolled. Functional endoscopic sinus surgery findings, scored as operating score, were analysed in relation to pre-operative olfactory recognition threshold and sinonasal computed tomography imaging score, as well as post-operative endoscopic appearance...
April 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29663114/impact-of-odontogenic-chronic-rhinosinusitis-on-general-health-related-quality-of-life
#5
Robert A Gaudin, Lloyd P Hoehle, Ralf Smeets, Max Heiland, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
Chronic rhinosinusitis (CRS) may arise due to odontogenic etiologies. However, it is unknown whether odontogenic CRS has a differential impact on patients' quality of life (QOL) compared to standard, inflammatory (but non-odontogenic) CRS. The objective of this study was to determine whether there is a difference in the impact of sinonasal symptomatology on general health-related QOL in odontogenic CRS compared to non-odontogenic CRS. This was a retrospective review of 21 odontogenic CRS patients who visited our tertiary care center...
April 17, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29661611/nasal-polyposis-or-chronic-olfactory-rhinitis
#6
R Jankowski, C Rumeau, P Gallet, D T Nguyen
The concept of chronic rhinosinusitis with or without polyps is founded on the structural and functional unicity of the pituitary mucosa and its united response to environmental aggression by allergens, viruses, bacteria, pollution, etc. The present review sets this concept against the evo-devo three-nose theory, in which nasal polyposis is distinguished as specific to the olfactory nose and in particular to the non-olfactory mucosa of the ethmoid, which is considered to be not a sinus but rather the skull-base bone harboring the olfactory mucosa...
April 13, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29661334/rhinosinusitis-and-allergies-in-elderly-patients
#7
REVIEW
Constanza J Valdés, Marc A Tewfik
The sinonasal tract plays important roles in respiration, olfaction, and defense against external pathogens. Like many organ systems, the nose and sinuses undergo several changes with advancing age that can play a role in the development of disease. This article discusses the physiology of the aging sinonasal tract and reviews the common diseases affecting older patients, such as rhinitis and rhinosinusitis.
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29660995/diagnostic-value-of-nasal-cytology-in-chronic-rhinosinusitis-assessed-by-a-liquid-based-cytological-technique
#8
Wenyu She, Jun Yang, Chengshuo Wang, Luo Zhang
Back ground: Nasal cytology has generally been employed as a useful diagnostic tool in the differentiation of rhinopathies. Objective The aim of this study was to assess the extent and diagnostic value of inflammation of nasal and paranasal sinus mucosa in chronic rhinosinusitis patients by employing a combination of nasal brushings and a liquid-based cytological technique. Methods Forty-eight patients with chronic sinusitis and 20 control subjects without any sign of sinusitis undergoing endoscopic surgery, although not all underwent endoscopic sinus surgery, were recruited to the study...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29649994/bile-acids-at-neutral-and-acidic-ph-induce-apoptosis-and-gene-cleavages-in-nasopharyngeal-epithelial-cells-implications-in-chromosome-rearrangement
#9
Sang-Nee Tan, Sai-Peng Sim
BACKGROUND: Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the component of gastric duodenal contents, has been recognised as a carcinogen. BA-induced apoptosis was suggested to be involved in human malignancies. Cells have the potential and tendency to survive apoptosis. However, cells that evade apoptosis upon erroneous DNA repair may carry chromosome rearrangements...
April 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29649892/a-pilot-comparison-between-caregiver-s-and-patient-s-perceived-quality-of-life-in-chronic-rhinosinusitis
#10
Katherine N Adams, Douglas Farquhar, Brent A Senior, Brian D Thorp, Adam M Zanation, Charles S Ebert
Introduction Chronic rhinosinusitis negatively impacts a patient's quality of life, but current studies only address the patient's perception of their disease. Caregivers living with the patient may have an alternative perception of the severity of the quality of life disturbance that patient's experience with chronic rhinosinusitis. Methods This was a prospective cohort study that enrolled patients with a confirmed chronic rhinosinusitis diagnosis who presented to clinic with a caregiver. At the initial visit, patients completed a Rhinosinusitis Disability Index...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29645354/the-price-of-pain-in-chronic-rhinosinusitis
#11
Kristine A Smith, Shaelene Ashby, Richard R Orlandi, Gretchen Oakley, Jeremiah A Alt
BACKGROUND: Chronic rhinosinusitis (CRS) is associated with productivity losses exceeding US$13 billion annually. Although pain is well known to significantly affect patient productivity in other diseases, its economic impact on CRS-related lost productivity has not been examined. The objective of this study was to determine whether CRS-related facial pain correlates with lost productivity in patients with CRS. METHODS: Seventy patients with CRS were enrolled in a cross-sectional investigation...
April 12, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29644907/remodeling-of-the-paradoxical-middle-turbinate-preserving-function-while-gaining-access
#12
Ryan H Belcher, Allison K Ikeda, John M DelGaudio
Background Endoscopic sinus surgery is performed for many reasons, most commonly for chronic rhinosinusitis refractory to medical treatment. A paradoxical middle turbinate is an anatomic variant that can hinder endoscopic access to the sinuses. No publication has addressed how to surgically treat a paradoxical middle turbinate. Method We present a basic endoscopic surgical approach to conservatively resect a paradoxical middle turbinate in order to improve access to the middle meatus and the sinuses while preserving support and function...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644906/does-heating-up-saline-for-nasal-irrigation-improve-mucociliary-function-in-chronic-rhinosinusitis
#13
Suthanma Nimsakul, Saran Ruxrungtham, Supinda Chusakul, Jesada Kanjanaumporn, Songklot Aeumjaturapat, Kornkiat Snidvongs
Background Mucociliary function is affected by temperature. Exposure to cold air may impair ciliary beat frequency. While saline nasal irrigation improves in ciliary beat activity, there is no evidence supporting the use of heated saline irrigation in treating patients with chronic rhinosinusitis. Objective To compare the effects of heated saline to room-temperature saline nasal irrigation on mucociliary clearance in chronic rhinosinusitis patients. Methods Adult patients with chronic rhinosinusitis were randomized into two groups receiving either heated saline or room-temperature saline nasal irrigation...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644905/histopathology-in-chronic-rhinosinusitis-varies-with-sinus-culture
#14
Ashley L Heilingoetter, Bobby Tajudeen, Hannah N Kuhar, Paolo Gattuso, Ritu Ghai, Mahboobeh Mahdavinia, Pete S Batra
Background Structured histopathology reporting facilitates better understanding of the underlying pathophysiologic mechanisms of chronic rhinosinusitis. The microbiology of chronic rhinosinusitis has been studied extensively; however, distinct histopathologic changes associated with bacteria isolated in chronic rhinosinusitis are largely unknown. Objective The goal of this study is to better understand the relationship between culturable bacteria and histopathology in chronic rhinosinusitis. Methods A structured histopathology report was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery in a group of patients with chronic rhinosinusitis refractory to medical therapy...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644903/patients-with-chronic-rhinosinusitis-and-obstructive-sleep-apnea-have-increased-paroxysmal-limb-movement
#15
Mahboobeh Mahdavinia, Jessica W Hui, Mohamed Zitun, Alejandra Lastra, James J Herdegen, Christopher D Codispoti, Rafsa J Khan, Phillip S LoSavio, Pete S Batra
BACKGROUND: Patients with chronic rhinosinusitis (CRS) frequently experience sleep disruption and are at a higher than normal risk for obstructive sleep apnea (OSA). The purpose of this study was to determine how CRS affects polysomnography findings and sleep-related breathing in OSA. METHODS: A cohort study was performed that included 107 adult patients with CRS and comorbid OSA (CRS+OSA group) and 137 patients with OSA and without CRS as the control group. An electronic medical records database was used to identify eligible subjects...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644866/diagnostic-accuracy-of-symptoms-endoscopy-and-imaging-signs-of-chronic-rhinosinusitis-without-nasal-polyps-compared-to-allergic-rhinitis
#16
A Koskinen, J Numminen, A Markkola, J Karjalainen, T Karstila, M Seppälä, A Julkunen, R Lemmetyinen, J Pekkanen, M Rautiainen, P Dastidar, M Hytönen, S Toppila-Salmi
Objectives The diagnosis of chronic rhinosinusitis without nasal polyps (CRSsNP) and distinguishing it from allergic rhinitis is difficult. Yet, early detection of CRSsNP is important to prevent progressive and severe chronic rhinosinusitis. Our aim was to compare diagnostic accuracy of symptoms, endoscopy, and imaging signs of CRSsNP and allergic rhinitis -only phenotypes. Setting Prospective controlled follow-up study. Participants Forty-two nonsmoking patients visiting tertiary care due to CRSsNP and 19 nonsmoking volunteer controls with allergic rhinitis filled a symptoms questionnaire and underwent nasal endoscopy off-seasonally...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29643854/the-role-of-quinine-responsive-taste-receptor-family-2-in-airway-immune-defense-and-chronic-rhinosinusitis
#17
Alan D Workman, Ivy W Maina, Steven G Brooks, Michael A Kohanski, Beverly J Cowart, Corrine Mansfield, David W Kennedy, James N Palmer, Nithin D Adappa, Danielle R Reed, Robert J Lee, Noam A Cohen
Background: Bitter (T2R) and sweet (T1R) taste receptors in the airway are important in innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) correlate with disease status and disease severity in chronic rhinosinusitis (CRS). Quinine is a bitter compound that is an agonist for several T2Rs also expressed on sinonasal cells, but not for T2R38. Because of this property, quinine may stimulate innate immune defense mechanisms in the airway, and functional differences in quinine perception may be reflective of disease status in CRS...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29626844/self-reported-anxiety-and-depression-are-unchanged-after-endoscopic-sinus-surgery-for-chronic-rhinosinusitis
#18
K N Adams, T A Schuman, C S Ebert, W You, M O Tomoum, B A Senior
BACKGROUND: Prior research has established that anxiety and depression, as measured by the Hospital Anxiety Depression Score (HADS), are strongly correlated with disease-specific quality of life (Rhinosinusitis Disability Index - RSDI) in chronic rhinosinusitis (CRS). We hypothesized that anxiety and depression would decrease after functional endoscopic sinus surgery (FESS), and furthermore that HADS would predict improvement in RSDI following surgery. METHODOLOGY: The study cohort from 2014 consisted of 99 CRS patients who underwent nasal endoscopy, RSDI, and HADS evaluation...
April 8, 2018: Rhinology
https://www.readbyqxmd.com/read/29624710/nasal-hyperreactivity-in-rhinitis-a-diagnostic-and-therapeutic-challenge
#19
REVIEW
Laura Van Gerven, Brecht Steelant, Peter W Hellings
Although nasal hyperreactivity (NHR) is a common feature in patients suffering from allergic and non-allergic rhinitis, it is widely neglected during history taking, underdiagnosed in the majority of patients with rhinitis and rhinosinusitis, not considered as an outcome parameter in clinical trials on novel treatments for rhinitis and rhinosinusitis, and no target for routine treatment. In contrast to the simple nature of diagnosing NHR by a history of nasal symptoms induced by non-specific exogenous and/or endogenous triggers, quantification is hardly performed in routine clinic given the lack of a simple tool for its diagnosis...
April 6, 2018: Allergy
https://www.readbyqxmd.com/read/29619105/assessment-of-pulmonary-function-before-and-after-sinus-surgery-in-lung-transplant-recipients
#20
Bernardo Faria Ramos, Fábio de Rezende Pinna, Silvia Vidal Campos, José Eduardo Afonso Júnior, Ricardo Henrique de Oliveira Braga Teixeira, Rafael Medeiros Carraro, Richard Louis Voegels
Introduction  The association between sinus and lung diseases is well known. However, there are scarce studies regarding the effects of sinus surgery on pulmonary function in lung transplant recipients. The present study describes our experience with sinus surgery in lung transplant recipients with chronic rhinosinusitis. Objectives  To assess the impact of sinus surgery for chronic rhinosinusitis on pulmonary function and on inpatient hospitalization days due to lower respiratory tract infection in lung transplant recipients...
April 2018: International Archives of Otorhinolaryngology
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