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https://www.readbyqxmd.com/read/29792153/antimicrobial-evaluation-of-erythrinan-alkaloids-from-erythrina-crista-galli-l
#1
Janaina M de Avila, Ionara I Dalcol, Alessandra O Pereira, Eveline W Santos, Adriano Ferraz, Maura Z Santos, Marco Aurelio Mostardeiro, Ademir F Morel
BACKGROUND: Several species of the genus Erythrina have been used as sedative, antidepressant, and anticonvulsant. Erythrina crista-galli is native to the Pampa Biome and is widely used for medicinal purposes. Erythrinan alkaloids exhibit a range of pharmacological properties. OBJECTIVE: The aim of this study was to evaluate the basic fractions and the alkaloids isolated from E. crista-galli bark against a collection of bacteria and fungi for the first time. METHODS: Erythrina crista-galli stem bark was extracted with MeOH under reflux...
May 23, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29792144/biomedical-applications-of-aromatic-azo-compounds-from-chromophore-to-pharmacophore
#2
Yousaf Ali, Shafida Abd Hamid, Umer Rashid
Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries. Besides their characteristic coloring function, biological properties of certain azo compounds including antibacterial, antiviral, antifungal and cytotoxic are also reported. Azo compounds can be used as drug carriers, either by acting as a 'cargo' that entrap therapeutic agents or by prodrug approach. The drug is released by internal or external stimuli in the region of interest, as observed in colon-targeted drug delivery...
May 23, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29788758/synthesis-and-biological-evaluation-of-2-aminothiazole-thiazolidinone-conjugates-as-potential-antitubercular-agents
#3
Mahmoud F Abo-Ashour, Wagdy M Eldehna, Riham F George, Marwa M Abdel-Aziz, Mahmoud M Elaasser, Sahar M Abou-Seri, Nagwa M Abdel Gawad
AIM: Mycobacterium tuberculosis, which causes tuberculosis, continues to infect millions of the global population, resulting in 1.8 million deaths worldwide in 2015. METHODOLOGY: Hybrids of 2-amino-4-methylthiazole bearing 5-acetyl/5-ethyl carboxylate functionality with 5-arylidene thiazolidinone moiety (6a-k and 9a-d) were synthesized and screened for antitubercular and antimicrobial activities. RESULTS & DISCUSSION: 5-ethyl carboxylate derivative 6k revealed half antitubercular activity (minimal inhibitory concentration = 1...
May 23, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29784842/eucast-determination-of-olorofim-f901318-susceptibility-of-mould-species-method-validation-and-mics
#4
Karin Meinike Jørgensen, Karen M T Astvad, Rasmus Krøger Hare, Maiken Cavling Arendrup
Olorofim is a novel antifungal agent with in vitro activity against Aspergillus and some other moulds. Here we addressed technical aspects for EUCAST olorofim testing and generated contemporary MIC data.EUCAST E.Def 9.3.1 testing was performed comparing two plate preparation methods (serial-dilution in medium (serial-plates) versus pre-dilution in DMSO (ISO-plates)), two lots of olorofim, visual (visual-MIC) versus spectrophotometer (spec-MIC) reading and four polystyrene plates using 34-53 Aspergillus isolates from five genera...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29781143/synthesis-and-evaluation-of-a-series-of-bis-pentylpyridinium-compounds-as-antifungal-agents
#5
Daniel Obando, Yasuko Koda, Namfon Pantarat, Sophie Lev, Xiaoming Zuo, Johanes Bijosono Oei, Fred Widmer, Julianne Djordjevic, Tania Sorrell, Katrina Jolliffe
A series of bis(4-pentylpyridinium) compounds with a variety of spacers between the pyridinium headgroups was synthesised and their antifungal activity has been investigated. Lengthening the alkyl spacer between the pentylpyridinium headgroups from twelve to sixteen methylene units resulted in increased antifungal activity against C. neoformans and C. albicans, but also resulted in increased hemolytic activity and cytotoxicity against mammalian cells. However, inclusion of an ortho-substituted benzene ring in the centre of the alkyl spacer resulted in reduced cytotoxicity and hemolytic activity, while maintaining antifungal potency...
May 20, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29780366/biological-control-of-mango-dieback-disease-caused-by-lasiodiplodia-theobromae-using-streptomycete-and-non-streptomycete-actinobacteria-in-the-united-arab-emirates
#6
Fatima H Kamil, Esam E Saeed, Khaled A El-Tarabily, Synan F AbuQamar
Dieback caused by the fungus Lasiodiplodia theobromae is an important disease on mango plantations in the United Arab Emirates (UAE). In this study, 53 actinobacterial isolates were obtained from mango rhizosphere soil in the UAE, of which 35 (66%) were classified as streptomycetes (SA) and 18 (34%) as non-streptomycetes (NSA). Among these isolates, 19 (12 SA and 7 NSA) showed antagonistic activities against L. theobromae associated with either the production of diffusible antifungal metabolites, extracellular cell-wall-degrading enzymes (CWDEs), or both...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29779647/in-vitro-susceptibility-and-multilocus-sequence-typing-of-fusarium-isolates-causing-keratitis
#7
P Dallé da Rosa, A Nunes, R Borges, B Batista, A Meneghello Fuentefria, L Z Goldani
Fungal keratitis is recognized as a significant cause of ocular morbidity and blindness especially in developing countries. In this study, we aimed to present the molecular identification and susceptibility of Fusarium isolates causing fungal keratitis in a university hospital in southern Brazil. The samples were identified using the second largest subunit of the RNA polymerase gene (RPB2) and the translation elongation factor 1-alpha (TEF1), while the antifungal susceptibility was tested by the broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) methodology...
May 17, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29778657/efficacy-of-antifungal-impregnated-cement-spacer-against-chronic-fungal-periprosthetic-joint-infections-after-total-knee-arthroplasty
#8
Jong-Keun Kim, Do-Yoon Lee, Dong-Wan Kang, Du-Hyun Ro, Myung Chul Lee, Hyuk-Soo Han
BACKGROUND: Although two-stage exchange arthroplasty is considered a treatment of choice for chronic features of fungal PJI (periprosthetic joint infection), there is no consensus for local use of antifungal agent. The purpose of this study was to evaluate the efficacy of antifungal-impregnated cement spacer (AICS). METHODS: Nine patients who were diagnosed and treated for chronic fungal PJI after TKA in a single center from January 2001 to December 2016 were enrolled...
May 16, 2018: Knee
https://www.readbyqxmd.com/read/29777985/liquid-chromatography-tandem-mass-spectrometry-for-the-quantification-of-moxifloxacin-ciprofloxacin-daptomycin-caspofungin-and-isavuconazole-in-human-plasma
#9
Julian Hösl, André Gessner, Nahed El-Najjar
A simple and precise ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the simultaneous analysis of five anti-infective agents used to treat severe infections [three antibiotics (daptomycin, moxifloxacin, ciprofloxacin) and two antifungals (isavuconazole, caspofungin)] in human plasma. Sample preparation was based on protein precipitation with ice cold methanol. All five agents were analyzed with the corresponding isotopically labeled internal standards. All analytes were detected in multiple reactions monitoring (MRM) using API 4000 triple-quadrupole mass spectrometer with electrospray (ESI) source operating in positive mode...
May 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29774477/cefepime-vs-cefoperazone-sulbactam-in-combination-with-amikacin-as-empirical-antibiotic-therapy-in-febrile-neutropenia
#10
M Ponraj, Biswajit Dubashi, B H Harish, S Kayal, S L Cyriac, Jogamaya Pattnaik, K Ranjith, Unni S Pillai, Naresh Jadhav, Kiran K Matta, Jagdeep Singh, Esha Jaffa, Bhanu Prakash
PURPOSE: Beta lactams are standard empirical therapy for febrile neutropenia (FN). The aim of this study was to evaluate the efficacy and safety of cefepime monotherapy compared with cefoperazone/sulbactam plus amikacin (CS + A) for empirical treatment of high risk FN. METHODS: One hundred seventy-five patients with 336 FN episodes were randomized to receive either cefepime (2 g q8h for adults and 50 mg/kg q8h for children) or CS (2 g q8h for adults and 50 mg/kg q8h for children) plus amikacin (15 mg/kg once a day)...
May 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29773744/worldwide-emergence-of-resistance-to-antifungal-drugs-challenges-human-health-and-food-security
#11
REVIEW
Matthew C Fisher, Nichola J Hawkins, Dominique Sanglard, Sarah J Gurr
The recent rate of emergence of pathogenic fungi that are resistant to the limited number of commonly used antifungal agents is unprecedented. The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals...
May 18, 2018: Science
https://www.readbyqxmd.com/read/29773436/non-sinonasal-isolated-facio-orbital-mucormycosis-a-case-report
#12
S K Swain, M C Sahu, A Banerjee
Mucormycosis is a rare clinical entity, often affect immunocompromised patients. It is an emergency situation and has poor prognosis. Prompt diagnosis with tissue biopsy, local control of the disease by aggressive surgical debridement and appropriate systemic antifungal treatment improve the prognosis and survival of the patients. Treatment of mucormycosis needs antifungal agents such as Amphotericin B and wide surgical debridement. Early diagnosis and treatment is often needed for survival of the patients...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29773435/epidemiology-of-antifungal-susceptibility-review-of-literature
#13
REVIEW
I Hadrich, A Ayadi
Fungal infections are a major cause of morbidity and mortality despite the latest developments of diagnostic tools and therapeutic options. Early initiation of the appropriate antifungal therapy has been demonstrated to have a direct impact on the patient's outcome. Antifungal susceptibility testing methods are available to detect antifungal resistance and to determine the best treatment for a specific fungus. American and European standards have been developed, as well as equivalent commercial systems, which are more appropriate for clinical laboratories...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29773008/antimicrobial-cytotoxic-anti-inflammatory-and-antioxidant-activity-of-culinary-processed-shiitake-medicinal-mushroom-lentinus-edodes-agaricomycetes-and-its-major-sulfur-sensory-active-compound-lenthionine
#14
Kristyna Kupcova, Iveta Stefanova, Zuzana Plavcova, Jan Hosek, Pavel Hrouzek, Roman Kubec
The antimicrobial, cytotoxic, anti-inflammatory, and antioxidant properties of aqueous extracts of raw and culinary processed shiitake mushrooms were evaluated and compared with those of lenthionine (1,2,3,5,6-penta-thiepane), the principal aroma-bearing substance of the shiitake medicinal mushroom (Lentinus edodes). Antimicrobial activity was tested using a panel of 4 strains of bacteria, 2 yeasts, and 2 fungi. Cytotoxic properties were evaluated against 3 cell lines (HepG2, HeLa, PaTu), whereas the anti-inflammatory activity of tested samples was assayed based on their ability to attenuate the secretion of the cytokine tumor necrosis factor-α...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29772529/microbial-bio-fuels-a-solution-to-carbon-emissions-and-energy-crisis
#15
Arun Kumar, Sumit Kaushal, Shubhini A Saraf, Jay Shankar Singh
Increasing energy demand, limited fossil fuel resources and climate change have prompted development of alternative sustainable and economical fuel resources such as crop-based bio-ethanol and bio-diesel. However, there is concern over use of arable land that is used for food agriculture for creation of biofuel. Thus, there is a renewed interest in the use of microbes particularly microalgae for bio-fuel production. Microbes such as micro-algae and cyanobacteria that are used for biofuel production also produce other bioactive compounds under stressed conditions...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29772356/assessment-of-toxicity-and-differential-antimicrobial-activity-of-methanol-extract-of-rhizome-of-simaba-ferruginea-a-st-hil-and-its-isolate-canthin-6-one
#16
Vanessa Fátima Gazoni, Sikiru Olaitan Balogun, Karuppusamy Arunacham, Darley Maria Oliveira, Valdir Cechinel Filho, Samara Rosolem Lima, Edson Moleta Colodel, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Simaba ferruginea A. St.-Hil., Simaroubaceae, popularly known as "calunga" is a typical subtropical shrub used in Central Brazil mainly for infection, anti-inflammatory, analgesic and gastric duodenal-ulcers. It presents in its composition the alkaloid canthin-6-one, an alkaloid indole β-carboxylic. AIM: This study aims to investigate the toxicity, antimicrobial activities of methanol extract of Simaba ferruginea (MESf) and canthin-6-one by using different experimental models...
May 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29770723/the-impact-of-azole-antifungal-drugs-on-imatinib-metabolism-in-human-liver-microsomes
#17
Xingxian Luo, Taifeng Li, Ze Yu, Xuecai Xue, Haiyang Zhao, Na Li, Liping Ma, Changqing Yang, Lin Huanglin, Wangyu Feng
1. Imatinib is widely used for the treatment of hematologic malignancies. It is common that imatinib is clinically co-prescribed with azole antifungal agents since these patients are more prone to invasive antifungal infection. The present study was to investigate the effects of azole antifungal drugs, including ketoconazole, fluconazole, voriconazole, itraconazole and posaconazole on imatinib metabolism. 2. The main metabolites, 1-OH midazolam and N-desmethyl imatinib, were determined in the absence and in the presence of various levels of ketoconazole, fluconazole, voriconazole, itraconazole and posaconazole...
May 17, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29770702/characterization-of-potentially-unsafe-ambulatory-antibiotic-use-and-associated-outcomes-in-an-adult-kidney-transplant-population
#18
Lindsay M Avery, Cory E Fominaya, Rena C Crawford, Katherine P Pleasants, David J Taber
BACKGROUND: Antibiotics are frequently prescribed to kidney transplant (KTX) recipients in the outpatient setting, but there are limited data assessing the safety and outcomes associated with this practice. OBJECTIVE: The primary objective of this study was to describe ambulatory antibiotic prescribing in a large cohort of adult KTX recipients. The secondary objective was to assess the outcomes associated with potentially unsafe antibiotic use in this population...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29769064/antimicrobial-and-antioxidant-activities-of-triterpenoid-and-phenolic-derivatives-from-two-cameroonian-melastomataceae-plants-dissotis-senegambiensis-and-amphiblemma-monticola
#19
Raissa Tioyem Nzogong, Fabrice Sterling Tchantchou Ndjateu, Steve Endeguele Ekom, Jules-Arnaud Mboutchom Fosso, Maurice Ducret Awouafack, Mathieu Tene, Pierre Tane, Hiroyuki Morita, Muhammad Iqbal Choudhary, Jean-de-Dieu Tamokou
BACKGROUND: Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and compounds isolated from Dissotis senegambiensis and Amphiblemma monticola, two Cameroonian Melastomataceae species traditionally used for the treatment of fever, malaria and infectious diseases. METHODS: The plant extracts were prepared by maceration in ethanol...
May 16, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29765440/prevalence-of-bacteria-and-fungi-in-samples-of-cornea-preservation-fluid
#20
Grażyna Broniek, Ewa Langwińska-Wośko, Małgorzata Sybilska, Jerzy Szaflik, Jacek P Szaflik, Marta Wróblewska
Introduction: Recipients of corneal transplants are at risk of healthcare-associated infections, which, apart from other causes of surgical site infections, may also occur as a result of the transfer of infected corneal tissue. In this study we assessed the risk of bacterial and fungal infections based on the results of routine microbiological testing of cornea preservation fluid samples. Material and methods: We examined a total of 725 samples of corneal preservation fluid, obtained during a period of 3 years (2011-2013)...
April 2018: Archives of Medical Science: AMS
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