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https://www.readbyqxmd.com/read/28107780/myb12-and-myb22-play-essential-roles-in-proanthocyanidin-and-flavonol-synthesis-in-red-fleshed-apple-malus-sieversii-f-niedzwetzkyana
#1
Nan Wang, Haifeng Xu, Shenghui Jiang, Zongying Zhang, Ninglin Lu, Huarong Qiu, Changzhi Qu, Yicheng Wang, Shujing Wu, Xuesen Chen
Flavonoids are major polyphenol compounds in plant secondary metabolism. Compared with cultivated apples, wild red-fleshed apples (Malus sieversii f. niedzwetzkyana) are excellent resources because of their high flavonoid content. In this work, R6R6, R6R1 and R1R1 genotypes were identified in an F1 segregating population of M. sieversii f. niedzwetzkyana. Significant differences in flavonoid compositions and contents were detected among the three genotypes by UPLC-ESI-TOF/MS analysis. Furthermore, two putative flavonoid-related genes encoding R2R3-MYB transcription factors, designated MYB12 and MYB22, were cloned and characterized...
January 20, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28107779/effects-of-mineralocorticoid-receptor-antagonists-on-the-progression-of-diabetic-nephropathy
#2
Li-Jing Sun, Yan-Ni Sun, Jian-Ping Shan, Geng-Ru Jiang
AIMS: We aimed to evaluate the potential benefits and adverse effects of adding a mineralocorticoid receptor antagonist (MRA) to angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin receptor blockers (ARB), as standard treatment in patients with DN. MATERIALS AND METHODS: We scanned the Embase, PubMed, and Cochrane Central Register of Controlled Trials databases for human clinical trials published in English until June 2016, evaluating renal outcomes in patients with DN...
January 20, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28107774/risk-factors-for-trachelectomy-following-supracervical-hysterectomy
#3
Ziv Tsafrir, Joelle Aoun, Eleni Papalekas, Andrew Taylor, Lauren Schiff, Evan Theoharis, David Eisenstein
We identified risk factors for trachelectomy after supracervical hysterectomy (SCH) due to persistence of symptoms MATERIAL AND METHODS: A retrospective case-control study in a university affiliated hospital. Seventeen patients who underwent a trachelectomy following SCH for nonmalignant indications between June 2002 and October 2014 were compared 68 randomly selected patients (controls) who underwent a SCH within the same time period. Demographics and clinical characteristics were compared between the study and control groups...
January 20, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28107772/a-preliminary-randomized-controlled-trial-of-contingency-management-for-alcohol-use-reduction-using-a-transdermal-alcohol-sensor
#4
Nancy P Barnett, Mark A Celio, Jennifer W Tidey, James G Murphy, Suzanne M Colby, Robert M Swift
AIMS: We tested the efficacy of daily contingent reinforcement for reducing alcohol use compared with (yoked) noncontingent reinforcement (NR) using a transdermal alcohol sensor to detect alcohol use. DESIGN: Pilot randomized controlled design with one baseline week, three intervention weeks, and one-month follow up. SETTING: New England, USA. PARTICIPANTS: Heavy drinking adults (47% female) not seeking treatment were randomized to 1) an escalating schedule of cash reinforcement (CR; n =15) for days on which alcohol was neither reported nor detected or 2) yoked NR (n =15)...
January 20, 2017: Addiction
https://www.readbyqxmd.com/read/28107771/a-prospective-study-of-maternal-fetal-and-neonatal-outcomes-in-the-setting-of-cesarean-section-in-low-and-middle-income-countries
#5
Margo S Harrison, Omrana Pasha, Sarah Saleem, Sumera Ali, Elwyn Chomba, Waldemar A Carlo, Ana L Garces, Nancy F Krebs, K Michael Hambidge, Shivaprasad S Goudar, Bhala Kodkany, Sangappa Dhaded, Richard J Derman, Archana Patel, Patricia L Hibberd, Fabian Esamai, Edward A Liechty, Janet L Moore, Dennis Wallace, Elizabeth M McClure, Menachem Miodovnik, Marion Koso-Thomas, Jose Belizan, Robert L Goldenberg
Cesarean section (CS) rates are increasing globally with an unclear effect on pregnancy outcomes. The study objective was to quantify maternal and perinatal morbidity and mortality in low- and middle-income countries associated with CS compared to vaginal delivery (VD) both within and across sites MATERIAL AND METHODS: A prospective population-based study including home and facility births in 337,153 women with a VD and 47,308 women with a CS from 2010 to 2015 was performed in Guatemala, India, Kenya, Pakistan, Zambia, and Democratic Republic of Congo...
January 20, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28107770/different-parts-different-stories-climate-sensitivity-of-growth-is-stronger-in-root-collars-versus-stems-in-tundra-shrubs
#6
Pascale Ropars, Sandra Angers-Blondin, Marianne Gagnon, Isla H Myers-Smith, Esther Lévesque, Stéphane Boudreau
Shrub densification has been widely reported across the circumpolar arctic and subarctic biomes in recent years. Long-term analyses based on dendrochronological techniques applied to shrubs have linked this phenomenon to climate change. However, the multi-stemmed structure of shrubs makes them difficult to sample and therefore leads to non-uniform sampling protocols among shrub ecologists, who will favor either root collars or stems to conduct dendrochronological analyses. Through a comparative study of the use of root collars and stems of Betula glandulosa, a common North American shrub species, we evaluated the relative sensitivity of each plant part to climate variables, and assessed if this sensitivity is consistent across three different types of environments in northwestern Québec, Canada (terrace, hilltop and snowbed)...
January 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28107769/the-transcriptional-modulator-ifrd1-controls-pgc-1%C3%AE-expression-under-short-term-adrenergic-stimulation-in-brown-adipocytes
#7
Gyujin Park, Tetsuhiro Horie, Takashi Kanayama, Kazuya Fukasawa, Takashi Iezaki, Yuki Onishi, Kakeru Ozaki, Yukari Nakamura, Yukio Yoneda, Takeshi Takarada, Eiichi Hinoi
Sympathetic tone activates the function of classical brown adipocytes, which constitutively exist in the brown adipose tissue, and inducible brown adipocytes (so-called beige adipocytes), which sporadically reside within the white adipose tissue. Here we identified the transcriptional modulator interferon-related developmental regulator 1 (Ifrd1) as a negative regulator of thermogenic and mitochondrial gene expression in brown adipocytes. Ifrd1 expression was markedly induced by cold exposure and administration of CL-316243 (a β3 adrenergic agonist) in interscapular brown adipose and inguinal subcutaneous white adipose tissues, but not in epididymal visceral white adipose tissue, in vivo...
January 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28107765/lower-adenoma-miss-rate-with-fuse-vs-conventional-colonoscopy-with-proximal-retroflexion-a-randomized-back-to-back-trial
#8
Ioannis S Papanikolaou, Periklis Apostolopoulos, Georgios Tziatzios, Erasmia Vlachou, Athanasios D Sioulas, Dimitrios Polymeros, Andreas Karameris, Ioannis Panayiotides, Georgios Alexandrakis, George D Dimitriadis, Konstantinos Triantafyllou
Background and study aims Full-spectrum colonoscopy (FSC) promises to increase adenoma detection by providing a wider field of view. The aim of this study was to compare adenoma miss rates of FSC with those of conventional colonoscopy complemented by right-colon re-examination using scope retroflexion (CC/R). Patients and methods At two tertiary endoscopy facilities, patients who were scheduled for colonoscopy for the assessment of symptoms or for colorectal cancer screening/surveillance were randomized (1:1) to undergo same-day, back-to-back colonoscopies (FSC or CC/R first), performed by one of five endoscopists who had documented adenoma detection rates > 35 %...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28107764/endoscopic-ultrasound-guided-biliary-access-versus-precut-papillotomy-in-patients-with-failed-biliary-cannulation-a-retrospective-study
#9
Alexander Lee, Anupam Aditi, Yasser M Bhat, Kenneth F Binmoeller, Chris Hamerski, Oriol Sendino, Steve Kane, John P Cello, Lukejohn W Day, Medi Mohamadnejad, V Raman Muthusamy, Rabindra Watson, Jason B Klapman, Sri Komanduri, Sachin Wani, Janak N Shah
Background and aims Precut papillotomy is widely used after failed biliary cannulation. Endoscopic ultrasound (EUS)-guided biliary access techniques are newer methods to facilitate access and therapy in failed cannulation. We evaluated the impact of EUS-guided biliary access on endoscopic retrograde cholangiopancreatography (ERCP) success and compared these techniques to precut papillotomy. Patients and methods We retrospectively compared two ERCP cohorts. One cohort consisted of biliary ERCPs (n = 1053) attempted in patients with native papillae and surgically unaltered anatomy in whom precut papillotomy and/or EUS-guided biliary access were routinely performed immediately after failed cannulation...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28107763/virtual-chromoendoscopy-i-scan-detects-more-polyps-in-patients-with-lynch-syndrome-a-randomized-controlled-crossover-trial
#10
Raf Bisschops, Sabine Tejpar, Hilde Willekens, Gert De Hertogh, Eric Van Cutsem
: Background and study aims (Virtual) chromoendoscopy detects more polyps than standard white-light endoscopy in patients with Lynch syndrome. Previous back-to-back trials did not randomize for the examination order, creating a possible bias in favor of chromoendoscopy. We aimed to assess the difference in polyp detection between high definition white-light endoscopy (HD-WLE) and virtual chromoendoscopy with I-SCAN in patients with Lynch syndrome. Patients and methods In this prospective, controlled trial, patients were randomized to either HD-WLE followed by I-SCAN (Group 1; n = 31) or I-SCAN followed by HD-WLE (Group 2; n = 30)...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28107762/thulium-laser-in-interventional-endoscopy-animal-and-human-studies
#11
Gian E Tontini, Helmut Neumann, Luca Pastorelli, Luisa Spina, Flaminia Cavallaro, Paola Soriani, Alessandro Rimondi, Barbara Bruni, Claudio Clemente, Filippo Fagnani, Pavlos Lagoussis, Luca Carmignani, Maurizio Vecchi
Background and study aims The thulium laser system (TLS) is an emerging surgical tool. The 2-μm wavelength provides a confined coagulation depth (0.2 - 0.4 mm) to reduce the potential for inadvertent injuries. For the first time ever, we assessed TLS feasibility for endoscopic hemostasis ex vivo in pigs. In addition, we performed the first in vivo hemostatic treatments in humans. Patients and methods Tissue damage induced by TLS using different settings and optical fibers was compared to that from argon plasma coagulation (APC) in established ex vivo animal models...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28107748/tracing-the-sources-and-cycling-of-phosphorus-in-river-sediments-using-oxygen-isotopes-methodological-adaptations-and-first-results-from-a-case-study-in-france
#12
Chiara Pistocchi, Federica Tamburini, Gerard Gruau, André Ferhi, Dominique Trevisan, Jean-Marcel Dorioz
An essential aspect of eutrophication studies is to trace the ultimate origin of phosphate ions (P-PO4) associated with the solid phase of river sediments, as certain processes can make these ions available for algae. However, this is not a straightforward task because of the diversity of allochthonous and autochthonous sources that can supply P-PO4 to river sediments as well as the existence of in-stream processes that can change the speciation of these inputs and obscure the original sources. Here, we present the results of a study designed to explore the potentials, limitations and conditions for the use of the oxygen isotope composition of phosphate (δ(18)Op) extracted from river sediments for this type of tracing...
December 26, 2016: Water Research
https://www.readbyqxmd.com/read/28107747/diversity-of-dna-viruses-in-effluents-of-membrane-bioreactors-in-traverse-city-mi-usa-and-la-grande-motte-france
#13
Evan O'Brien, Mariya Munir, Terence Marsh, Marc Heran, Geoffroy Lesage, Volodymyr V Tarabara, Irene Xagoraraki
This study assesses diversity of DNA viruses in the effluents of two membrane bioreactor (MBR) wastewater treatment plants (WWTPs): an MBR in the United States and an MBR in France. Viral diversity of these effluents is compared to that of a conventional activated sludge WWTP in the U.S. Diversity analysis indicates Herpesvirales to be the most abundant order of potentially pathogenic human DNA viruses in wastewater treated effluent in all utilities. Other potentially pathogenic human viruses detected include Adenoviridae, Parvoviridae, and Polyomaviridae...
January 8, 2017: Water Research
https://www.readbyqxmd.com/read/28107745/femtomolar-detection-of-cardiac-troponin-i-using-a-novel-label-free-and-reagent-free-dendrimer-enhanced-impedimetric-immunosensor
#14
Rashida Akter, Bongjin Jeong, Yong-Mi Lee, Jong-Soon Choi, Md Aminur Rahman
A novel highly sensitive dendrimer coupled impedimetric immunosensor was developed for the label-free and reagent-free detection of cardiac troponin I (TnI) in serum samples. The immunosensor probe was fabricated by covalently attaching carboxylic acid-functionalized third generation (G3) poly (amidoamine) (PAMAM) dendrimer (Den) on the 3, 3', 5, 5'-tetramethyl benzidine (TMB) modified 6-mercaptohexanoic acid (MHA) self-assembled monolayer (SAM) on a gold (Au) electrode. Monoclonal anti-TnI antibody was then covalently immobilized on the Den and TMB attached MHA SAM modified surface...
January 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28107742/heavy-rare-earth-elements-affect-early-life-stages-in-paracentrotus-lividus-and-arbacia-lixula-sea-urchins
#15
Rahime Oral, Giovanni Pagano, Antonietta Siciliano, Maria Gravina, Anna Palumbo, Immacolata Castellano, Oriana Migliaccio, Philippe J Thomas, Marco Guida, Franca Tommasi, Marco Trifuoggi
BACKGROUND: Heavy rare earth elements (HREEs) have been scarcely studied for their toxicity, in spite of their applications in several technologies. Thus HREEs require timely investigations for their adverse health effects. METHODS: Paracentrotus lividus and Arbacia lixula embryos and sperm were exposed to trichloride salts of five HREEs (Dy, Ho, Er, Yb and Lu) and to Ce(III) as a light REE (LREE) reference to evaluate: 1) developmental defects (% DD) in HREE-exposed larvae or in the offspring of HREE-exposed sperm; 2) mitotic anomalies; 3) fertilization success; and 4) reactive oxygen species (ROS) formation, and nitric oxide (NO) and malondialdehyde (MDA) levels...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28107741/building-related-symptoms-are-linked-to-the-in-vitro-toxicity-of-indoor-dust-and-airborne-microbial-propagules-in-schools-a-cross-sectional-study
#16
J T Salin, M Salkinoja-Salonen, P J Salin, K Nelo, T Holma, P Ohtonen, H Syrjälä
INTRODUCTION: Indoor microbial toxicity is suspected to cause some building-related symptoms, but supporting epidemiological data are lacking. OBJECTIVE: We examined whether the in vitro toxicity of indoor samples from school buildings was associated with work-related health symptoms (building-related symptoms, BRS). METHODS: Administrators of the Helsinki City Real Estate Department selected 15 schools for the study, and a questionnaire on symptoms connected to work was sent to the teachers in the selected schools for voluntary completion...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28107738/hyperglycemia-and-glycemic-variability-are-associated-with-the-severity-of-sepsis-in-nondiabetic-subjects
#17
Lukana Preechasuk, Nattakarn Suwansaksri, Nantawan Ipichart, Sathit Vannasaeng, Chairat Permpikul, Apiradee Sriwijitkamol
PURPOSE: The purpose was to compare glucose variability (GV) obtained via continuous glucose monitoring between nondiabetic sepsis patients and healthy subjects and to seek associations between GV and sepsis severity in nondiabetic sepsis patients. METHODS: Nondiabetic sepsis inpatients and healthy controls received a 72-hour continuous glucose monitoring (iPro2, Medtronic) postadmission and post-oral glucose tolerance test, respectively. The mean glucose level (MGL) along with GV represented by standard deviation (SD) and the mean amplitude of glycemic excursion (MAGE) were calculated at 24 and 72 hours...
December 10, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28107735/breast-cancers-detected-in-only-one-of-two-arms-of-a-tomosynthesis-3d-mammography-population-screening-trial-storm-2
#18
Daniela Bernardi, Nehmat Houssami
The prospective 'screening with tomosynthesis or standard mammography-2 (STORM-2)' trial compared mammography screen-reading strategies and showed that each of integrated 2D/3D-mammography or 2Dsynthetic/3D-mammography detected significantly more breast cancers than 2D-mammography alone. This short report describes 13 (from 90) cancers detected in only one of two parallel double-reading arms implemented in STORM-2. Amongst this subset of cases, the majority was invasive cancer ≤16 mm, mostly depicted as irregular masses or distortions...
January 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28107733/glycine-increases-cold-tolerance-in-rice-via-the-regulation-of-n-uptake-physiological-characteristics-and-photosynthesis
#19
Cao Xiaochuang, Zhong Chu, Zhu Lianfeng, Zhang Junhua, Sajid Hussain, Wu Lianghuan, Jin Qianyu
To investigate the response of rice growth and photosynthesis to different nitrogen (N) sources under cold stress, hydroponic cultivation of rice was done in greenhouse, with glycine, ammonium, and nitrate as the sole N sources. The results demonstrate that exposure to low temperature reduced the rice biomass and leaf chlorophyll content, but their values in the glycine-treated plants were significantly higher than in the ammonium- and nitrate-treated plants. This might be attributed to the higher N uptake rate and root area and activity in the glycine-treated plants...
January 12, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28107732/comparative-analysis-of-polyamine-metabolism-in-wheat-and-maize-plants
#20
Gabriella Szalai, Katalin Janda, Éva Darkó, Tibor Janda, Violeta Peeva, Magda Pál
In the present work changes in polyamine contents were investigated after various hydroponic polyamine treatments (putrescine, spermidine and spermine at 0.1, 0.3 and 0.5 mM concentrations) in two different crop species, wheat and maize. In contrast to putrescine, higher polyamines (spermidine and spermine) induced concentration-dependent oxidative damage in both crops, resulting in decreased biomass. The unfavourable effects of polyamines were more pronounced in the roots, and maize was more sensitive than wheat...
January 12, 2017: Plant Physiology and Biochemistry: PPB
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