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https://www.readbyqxmd.com/read/28743167/preoperative-bevacizumab-and-volumetric-recovery-after-resection-of-colorectal-liver-metastases
#1
Georgios Antonios Margonis, Stefan Buettner, Nikolaos Andreatos, Kazunari Sasaki, Manijeh Zargham Pour, Ammar Deshwar, Jane Wang, Mounes Aliyari Ghasebeh, Christos Damaskos, Neda Rezaee, Timothy M Pawlik, Christopher L Wolfgang, Ihab R Kamel, Matthew J Weiss
BACKGROUND AND OBJECTIVES: While preoperative treatment is frequently administered to CRLM patients, the impact of chemotherapy, with or without bevacizumab, on liver regeneration remains controversial. METHODS: The early and late regeneration indexes were defined as the relative increase in liver volume (RLV) within 2 and 9 months from surgery. Regeneration rates of the preoperative treatment groups were compared. RESULTS: Preoperative chemotherapy details and volumetric data were available for 185 patients; 78 (42...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28743091/performance-comparison-of-two-herbal-and-industrial-medicines-using-nanoparticles-with-a-starch-cellulose-shell-and-alginate-core-for-drug-delivery-in-vitro-studies
#2
Akbar Esmaeili, Sahar Behzadi
In this study, the performance of two kinds of industrial and herbal drugs encapsulated in nanoparticles with a shell of starch and cellulose and an alginate core were examined as a new technique for nanoparticle drug delivery. The test method involved creating a suspension of starch and alginate, which was then dried, mixed with cellulose, and heated to form core-shell nanoparticles. The industrial drug calcitonin and an extract of the herb Amaranthus retroflexcus L. were added separately and in combination to the nanoparticles, and the performance of each configuration was evaluated...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28743088/chitosan-derived-co-spheroids-of-neural-stem-cells-and-mesenchymal-stem-cells-for-neural-regeneration
#3
Hao-Wei Han, Shan-Hui Hsu
Chitosan has been considered as candidate biomaterials for neural applications. The effective treatment of neurodegeneration or injury to the central nervous system (CNS) is still in lack nowadays. Adult neural stem cells (NSCs) represents a promising cell source to treat the CNS diseases but they are limited in number. Here, we developed the core-shell spheroids of NSCs (shell) and mesenchymal stem cells (MSCs, core) by co-culturing cells on the chitosan surface. The NSCs in chitosan derived co-spheroids displayed a higher survival rate than those in NSC homo-spheroids...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28743000/cilia-control-fat-deposition-during-tissue-repair
#4
Eusebio Perdiguero, Antonio L Serrano, Pura Muñoz-Cánoves
Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling.
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28742438/effect-of-low-level-laser-therapy-on-bone-regeneration-during-osseointegration-and-bone-graft
#5
Randa Zein, Wayne Selting, Stefano Benedicenti
BACKGROUND: The effect of low-level laser therapy (LLLT) on bone regeneration during osseointegration and bone graft is very controversial. Despite many positive reports of in vitro and in vivo studies and more than 50 randomized clinical trials claiming a positive effect of photobiomodulation (PBM), many reports found no significant effect of lasers. OBJECTIVE: The aim of this study was to evaluate studies correlating PBM and bone regeneration and to assesses parameters that produce positive results based on dose and output power used...
July 21, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28742322/modeling-mechanochemical-reaction-mechanisms
#6
Heather Adams, Brendan P Miller, Octavio J Furlong, Marzia Fantauzzi, Gabriele Navarra, Antonella Rossi, Yufu Xu, Peter V Kotvis, Wilfred T Tysoe
The mechanochemical reaction between copper and dimethyl disulfide is studied under well-controlled conditions in ultrahigh vacuum (UHV). Reaction is initiated by fast S-S bond scission to form adsorbed methyl thiolate species, and the reaction kinetics are reproduced by two subsequent elementary mechanochemical reaction steps, namely a mechanochemical decomposition of methyl thiolate to deposit sulfur on the surface and evolve small, gas-phase hydrocarbons, and sliding-induced oxidation of the copper by sulfur that regenerates vacant reaction sites...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28742154/lipopolysaccharide-inhibits-myogenic-differentiation-of-c2c12-myoblasts-through-the-toll-like-receptor-4-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-and-myoblast-derived-tumor-necrosis-factor-%C3%AE
#7
Yuko Ono, Kazuho Sakamoto
BACKGROUND: Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or with various endogenous diseases that are associated with metabolic endotoxemia. Involuntary loss of skeletal muscle, termed muscle wasting, is commonly observed in these conditions, suggesting that circulating LPS might play an essential role in its development. Although impairment of muscle regeneration is an important determinant of skeletal muscle wasting, it is unclear whether LPS affects this process and, if so, by what mechanism...
2017: PloS One
https://www.readbyqxmd.com/read/28742111/axonal-outgrowth-neuropeptides-expression-and-receptors-tyrosine-kinase-phosphorylation-in-3d-organotypic-cultures-of-adult-dorsal-root-ganglia
#8
Estrela Neto, Cecília J Alves, Luís Leitão, Daniela M Sousa, Inês S Alencastre, Francisco Conceição, Meriem Lamghari
Limited knowledge from mechanistic studies on adult sensory neuronal activity was generated, to some extent, in recapitulated adult in vivo 3D microenvironment. To fill this gap there is a real need to better characterize the adult dorsal root ganglia (aDRG) organotypic cultures to make these in vitro systems exploitable for different approaches, ranging from basic neurobiology to regenerative therapies, to address the sensory nervous system in adult stage. We conducted a direct head-to-head comparison of aDRG and embryonic DRG (eDRG) organotypic culture focusing on axonal growth, neuropeptides expression and receptors tyrosine kinase (RTK) activation associated with neuronal survival, proliferation and differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/28741938/new-synthesis-of-nzvi-c-composites-as-an-efficient-adsorbent-for-the-uptake-of-u-vi-from-aqueous-solutions
#9
Haibo Liu, Mengxue Li, Tianhu Chen, Changlun Chen, Njud S Alharbi, Tasawar Hayat, Dong Chen, Qiang Zhang, Yubing Sun
New nanoscale zero-valent iron/carbon (nZVI/C) composites were successfully synthesized by heating natural hematite and pine sawdust at 800 ºC under nitrogen conditions. The characteristic results indicated that as-prepared nZVI/C composites presented the massive reactive sites by SEM, XRD, FT-IR and XPS techniques. No effect of ionic strength revealed that inner-sphere surface complexation dominated uptake of U(VI) on nZVI/C composites. The uptake mechanism of U(VI) on nZVI/C composites was demonstrated to be the simultaneous adsorption and reduction by XPS and XANES techniques...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28741921/bioinspired-composite-matrix-containing-ha-silica-core-shell-nanorods-for-bone-tissue-engineering
#10
Anitha A, Deepthy Menon, Sivanarayanan Tb, Manzoor Koyakutty, Chandini C Mohan, Shantikumar V Nair, Manitha B Nair
Development of multifunctional bioinspired scaffolds that can stimulate vascularization and rege-neration is necessary for application in bone tissue engineering. Herein, we report a composite matrix containing Hydroxyapatite (HA) - silica core shell nanorods with good biocompatibility, osteogenic differentiation, vascularization and bone regeneration potential. The biomaterial consist of crystalline, rod-shaped nanoHA core with uniform amorphous silica sheath (Si-nHA) that retains the characteristic phases of the individual components, confirmed by HR-TEM, XRD, XPS and FTIR...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28741902/corneal-confocal-sub-basal-nerve-plexus-evaluation-a-review
#11
REVIEW
Joanna Kokot, Adam Wylęgała, Bogumił Wowra, Łukasz Wójcik, Dariusz Dobrowolski, Edward Wylęgała
The aim of this study was to review the most recent data about corneal sub-basal nerve plexus (SNP) evaluated with the use of corneal confocal microscopy (CCM). For this purpose, an electronic search was conducted based on PubMed and Google Scholar and Web of Science databases from 2008 up to the end of 2016. Ninety-eight articles in English were cited, as well as abstracts in other languages, concerning the morphology and function of corneal SNP in various diseases. Changes in corneal SNP as a result of local treatment were also introduced...
July 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28741893/when-epigenetics-meets-bioengineering-a-material-characteristics-and-surface-topography-perspective
#12
REVIEW
Lena Larsson, Sophia P Pilipchuk, William V Giannobile, Rogerio M Castilho
The field of tissue engineering and regenerative medicine (TE/RM) involves regeneration of tissues and organs using implantable biomaterials. The term epigenetics refers to changes in gene expression that are not encoded in the DNA sequence, leading to remodeling of the chromatin and activation or inactivation of gene expression. Recently, studies have demonstrated that these modifications are influenced not only by biological cues but also by mechanical and topographical signals. This review highlights the current knowledge on emerging approaches in TE/RM with a focus on the effect of materials and topography on the epigenetic expression pattern in cells with potential impacts on modulating regenerative biology...
July 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28741758/stem-cell-derived-exosomes-a-promising-strategy-for-fracture-healing
#13
REVIEW
Zi-Chen Hao, Jun Lu, Shan-Zheng Wang, Hao Wu, Yun-Tong Zhang, Shuo-Gui Xu
OBJECTIVES: To describe the biological characteristics of exosomes and to summarize the current status of stem cell-derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed. METHODS: Search and analyze the related articles in pubmed database through the multi-combination of keywords like "stem cells","exosomes","bone regeneration" and "fracture healing". CONCLUSION: Stem cell-derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention...
July 25, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28741748/porous-organic-polymers-for-post-combustion-carbon-capture
#14
REVIEW
Lanfang Zou, Yujia Sun, Sai Che, Xinyu Yang, Xuan Wang, Matheiu Bosch, Qi Wang, Hao Li, Mallory Smith, Shuai Yuan, Zachary Perry, Hong-Cai Zhou
One of the most pressing environmental concerns of our age is the escalating level of atmospheric CO2 . Intensive efforts have been made to investigate advanced porous materials, especially porous organic polymers (POPs), as one type of the most promising candidates for carbon capture due to their extremely high porosity, structural diversity, and physicochemical stability. This review provides a critical and in-depth analysis of recent POP research as it pertains to carbon capture. The definitions and terminologies commonly used to evaluate the performance of POPs for carbon capture, including CO2 capacity, enthalpy, selectivity, and regeneration strategies, are summarized...
July 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28741725/cell-derived-micro-environment-helps-dental-pulp-stem-cells-promote-dental-pulp-regeneration
#15
Xuexin Zhang, Hui Li, Jingjing Sun, Xiangyou Luo, Hefeng Yang, Li Xie, Bo Yang, Weihua Guo, Weidong Tian
OBJECTIVES: The function of the dental pulp is closely connected to the extracellular matrix (ECM) structure, and ECM has received significant attention due to its biological functions for regulating cells. As such, the interaction between the ECM niche and cells is worth exploring for potential clinical uses. MATERIALS AND METHODS: In this study, dental pulp stem cell (DPSC)-derived ECM (DPM) was prepared through cell culture and decellularization to function as the cell niche, and changes in DPSC behaviour and histological analysis of dental pulp tissue regeneration were evaluated following the DPM culture...
July 25, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28741505/emerging-roles-for-eosinophils-in-the-tumor-microenvironment
#16
REVIEW
Hadar Reichman, Danielle Karo-Atar, Ariel Munitz
Eosinophils are evolutionary conserved cells largely studied in the context of allergy. Although eosinophils were first described in tumors more than 120 years ago, their roles in cancer are often overlooked. This is puzzling given their potent immune modulatory, cytotoxic, and/or tissue repair capabilities, and recent studies demonstrating key roles for eosinophils in contexts far beyond their 'classical' field (e.g., metabolism, thermogenesis, and tissue regeneration). Recent data suggest that this frequently ignored cell is emerging as a potent immune effector and immune modulator in the tumor microenvironment...
November 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28741427/receptor-activator-of-nuclear-factor-kappa-b-ligand-rankl-induced-local-osteoporotic-canine-mandible-model-for-the-evaluation-of-peri-implant-bone-regeneration
#17
Chang Ah Ryum, Tae Hyung Cho, Soon Jung Hwang
The canine mandible is useful for studying bone regeneration after dental implant placement. However, it is limited in investigations of peri-implant osteogenesis under osteoporotic conditions due to the insignificant osteoporotic effect of ovariectomy. This study aimed to establish a local osteoporotic model without ovariectomy using receptor activator of nuclear factor kappa-B ligand (RANKL) in a canine mandible model. This new model was used to evaluate the effects of injectable β-tricalcium phosphate microsphere bone grafts (TCP) on peri-implant bone regeneration under osteoporotic conditions with combinations of human recombinant bone morphogenetic protein-2 (rhBMP-2)...
July 25, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28741412/directly-induced-neural-differentiation-of-human-adipose-derived-stem-cells-using-3d-culture-system-of-conductive-microwell-with-electrical-stimulation
#18
Dong Nyung Heo, Nana Acquah, Junghoon Kim, Se-Jun Lee, Nathan J Castro, Lijie Grace Zhang
Adipose-derived stem cells (ADSCs) have the capacity to differentiate into neural precursor cells which can be used for nerve regeneration. However, their inherently low neurogenic differentiation efficiency limits further clinical applications. This study was designed to promote neurogenic differentiation efficacy of ADSCs via integrating conductive hydrogel-based microwells with electrical stimulation (ES). We hypothesize that ADSCs will differentiate more efficiently into neural precursor cells when electrically stimulated in conductive hydrogel microwells...
July 25, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28741310/homo-and-heteropolymer-self-assembly-of-recombinant-trichocytic-keratins
#19
Rachael N Parker, Kristina L Roth, Christina Kim, Jennifer P McCord, Mark E Van Dyke, Tijana Z Grove
In the past two decades, keratin biomaterials have shown impressive results as scaffolds for tissue engineering, wound healing, and nerve regeneration. In addition to its intrinsic biocompatibility, keratin interacts with specific cell receptors eliciting beneficial biochemical cues. However, during extraction from natural sources, such as hair and wool fibers, natural keratins are subject to extensive processing conditions that lead to formation of unwanted by-products. Additionally, natural keratins suffer from limited sequence tunability...
July 24, 2017: Biopolymers
https://www.readbyqxmd.com/read/28740984/combined-effects-of-multi-scale-topographical-cues-on-stable-cell-sheet-formation-and-differentiation-of-mesenchymal-stem-cells
#20
Sisi Li, Shreyas Kuddannaya, Yon Jin Chuah, Jingnan Bao, Yilei Zhang, Dongan Wang
To decipher specific cell responses to diverse and complex in vivo signals, it is essential to emulate specific surface chemicals, extra cellular matrix (ECM) components and topographical signals through reliable and easily reproducible in vitro systems. However, the effect of multiple cues such as micro-hole/pillar architectures under a common and easily tunable platform remains unexplored. Recently we have demonstrated the positive influence of surface chemical modification of polydimethylsiloxane (PDMS) surfaces on directing long-term adhesion, viability and potency of hMSCs...
July 25, 2017: Biomaterials Science
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