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https://www.readbyqxmd.com/read/28927044/isolation-and-characterization-of-adult-mammary-stem-cells-from-breast-cancer-adjacent-tissues
#1
Ai-Ping Shi, Zhi-Min Fan, Ke-Wei Ma, Yan-Fang Jiang, Lei Wang, Ke-Wei Zhang, Shi-Bo Fu, Ning Xu, Zhi-Ru Zhang
Normal adult mammary stem cells (AMSCs) are promising sources for breast reconstruction, particularly following the resection of breast tumors. However, carcinogenic events can potentially convert normal AMSCs to cancer stem cells, posing a safety concern for the use of AMSCs for clinical tissue regeneration. In the present study, AMSCs and autologous primary breast cancer cells were isolated and compared for their ability to differentiate, their gene expression profile, and their potential to form tumors in vivo...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926961/effects-of-metal-ions-temperature-and-a-denaturant-on-the-oxidative-folding-pathways-of-bovine-%C3%AE-lactalbumin
#2
Reina Shinozaki, Michio Iwaoka
Bovine α-lactalbumin (αLA) has four disulfide (SS) bonds in the native form (N). On the oxidative folding pathways of this protein, two specific SS folding intermediates, i.e., (61-77, 73-91) and des[6-120], which have two and three native SS bonds, respectively, accumulate predominantly in the presence of Ca(2+). In this study, we reinvestigated the pathways using a water-soluble cyclic selenoxide reagent, trans-3,4-dihydroxyselenolane oxide (DHS(ox)), as a strong and quantitative oxidant to oxidize the fully reduced form (R)...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28926842/pharmacotherapy-with-thymoquinone-improved-pancreatic-%C3%AE-cell-integrity-and-functional-activity-enhanced-islets-revascularization-and-alleviated-metabolic-and-hepato-renal-disturbances-in-streptozotocin-induced-diabetes-in-rats
#3
Adel Galal El-Shemi, Osama Adnan Kensara, Aiman Alsaegh, Mohammed Hasan Mukhtar
AIMS: This study is aimed at evaluating the antidiabetic effects of thymoquinone (TQ) on streptozotocin (STZ)-induced diabetes in rats, and exploring the possible underlying mechanisms. METHODS: Diabetes was induced in adult male Wistar rats by intraperitoneal injection of freshly prepared STZ (65 mg/kg). After disease induction, 42 rats were equally assigned to: controls, STZ-diabetic group, and STZ-diabetic group treated with oral TQ (35 mg/kg/day) for 5 weeks...
September 20, 2017: Pharmacology
https://www.readbyqxmd.com/read/28926810/revisiting-the-biogeochemistry-of-arsenic-in-the-baltic-sea-impact-of-anthropogenic-activity
#4
Lei Li, Christa Pohl, Jing-Ling Ren, Detlef Schulz-Bull, Xiu-Hong Cao, Günther Nausch, Jing Zhang
With the increase in anthropogenic environmental disruption, the behavior of arsenic in the Baltic Sea has received more scientific attention because of its complex forms and toxicity, and was re-visited to determine if there have been measurable changes recently. A cruise was conducted in 10-19 May 2011 to investigate the species and distribution of total dissolved inorganic arsenic (TDIAs: [TDIAs]=[As(V)]+[As(III)]) revealing links between the hydrographic dynamics and biological/chemical reactions in the Baltic Sea...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28926622/a-high-mitochondrial-transport-rate-characterizes-cns-neurons-with-high-axonal-regeneration-capacity
#5
Romain Cartoni, Gulcin Pekkurnaz, Chen Wang, Thomas L Schwarz, Zhigang He
Improving axonal transport in the injured and diseased central nervous system has been proposed as a promising strategy to improve neuronal repair. However, the contribution of each cargo to the repair mechanism is unknown. DRG neurons globally increase axonal transport during regeneration. Because the transport of specific cargos after axonal insult has not been examined systematically in a model of enhanced regenerative capacity, it is unknown whether the transport of all cargos would be modulated equally in injured central nervous system neurons...
2017: PloS One
https://www.readbyqxmd.com/read/28926122/stem-cells-and-differentiated-cells-differ-in-their-sensitivity-to-urine-in-vitro
#6
Marta Pokrywczyńska, Tomasz Kloskowski, Daria Balcerczyk, Monika Buhl, Arkadiusz Jundziłł, Maciej Nowacki, Kaja Męcińska-Jundziłł, Tomasz Drewa
INTRODUCTION: Urinary tract regeneration using tissue engineering is one of the most challenging issues in the field of reconstructive urology. Cells seeded on scaffold are exposed to urine immediately after the implantation. The outcome of urinary bladder regeneration is depended on the ability of these cells to survive, proliferate and regenerate. The aim of this study was to compare a sensitivity of three different cell lines to urine in vitro. MATERIAL AND METHODS: Three different cell lines were isolated from porcine bladder (urothelial cells, UCs and smooth muscle cells, SMCs) and adipose tissue (adipose-derived stem cells, ADSCs)...
September 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28926102/in-situ-temperature-relationships-of-biochemical-and-stomatal-controls-of-photosynthesis-in-four-lowland-tropical-tree-species
#7
Martijn Slot, Klaus Winter
Net photosynthetic carbon uptake of Panamanian lowland tropical forest species is typically optimal at 30-32°C. The processes responsible for the decrease in photosynthesis at higher temperatures are not fully understood for tropical trees. We determined temperature responses of maximum rates of RuBP-carboxylation (VCMax ) and RuBP-regeneration (JMax ), stomatal conductance (Gs ) and respiration in the light (RLight ) in situ for four lowland tropical tree species in Panama. Gs had the lowest temperature optimum (TOpt ), similar to that of net photosynthesis, and photosynthesis became increasingly limited by stomatal conductance as temperature increased...
September 19, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28926067/3-aminoperylene-and-ascorbate-in-aqueous-sds-one-green-laser-flash-%C3%A2-and-action-sustainably-detoxifying-a-recalcitrant-chloro-organic
#8
Tim Kohlmann, Robert Naumann, Christoph Kerzig, Martin Goez
The hydrated electron represents a "super-reductant" in water, providing 2.9 eV of reductive power, which suffices to decompose nonactivated aliphatic halides. We show that 3-amino-perylene in SDS micelles, when combined with the bioavailable ascorbate as an extramicellar sacrificial donor, sustainably produces hydrated electrons through photoredox catalysis with green light, from a metal-free system, and at near-physiological pH. Photoionization of the amine with a 532 nm laser yields an extremely long-lived radical cation as the by-product, and a subsequent reaction of the latter with the sacrificial donor across the micelle/water interface regenerates the catalyst...
September 19, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28925552/in-situ-bone-tissue-engineering-with-an-endogenous-stem-cell-mobilizer-and-osteoinductive-nanofibrous-polymeric-scaffolds
#9
Jong Seung Lee, Yoonhee Jin, Hyun-Ji Park, Kisuk Yang, Min Suk Lee, Hee Seok Yang, Seung-Woo Cho
Classical bone tissue engineering involves the use of culture-expanded cells and scaffolds to produce tissue constructs for transplantation. Despite promising results, clinical adoption of these constructs has been limited due to various drawbacks, including extensive cell expansion steps, low cell survival rate upon transplantation, and the possibility of immuno-rejection. To bypass the ex vivo cell culture and transplantation process, we exploited the regenerative capacity of the host by mobilizing endogenous stem cells to the site of injury...
September 19, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28925546/multidisciplinary-full-mouth-rehabilitation-with-soft-tissue-regeneration-in-the-esthetic-zone
#10
Anja Liebermann, Stefan Frei, Madalena Lucia Pinheiro Dias Engler, Otto Zuhr, Otto Prandtner, Daniel Edelhoff, Reza Saeidi Pour
OBJECTIVE: Oral rehabilitation often requires a multidisciplinary approach including restorative dentistry, prosthodontics, and periodontology to fulfill high esthetic and functional demands, frequently combined with changes in the vertical dimension. The presence of gingival recessions can be associated with numerous factors, such as brushing or preparation trauma and persistent inflammation of the gingiva due to inadequate marginal fit of restorations. Because gingival recessions can cause major esthetic and functional problems, obtaining stability of the gingival tissue around prosthetic restorations is of essential concern...
September 19, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28925355/loss-of%C3%A2-foxo-rescues-stem-cell-aging-in-drosophila-germ-line
#11
Filippo Artoni, Rebecca Kreipke, Ondina Palmeira, Connor Dixon, Zachary Goldberg, Hannele Ruohola-Baker
Aging stem cells lose the capacity to properly respond to injury and regenerate their residing tissues. Here, we utilized the ability of Drosophila melanogaster germline stem cells (GSCs) to survive exposure to low doses of ionizing radiation (IR) as a model of adult stem cell injury and identified a regeneration defect in aging GSCs: while aging GSCs survive exposure to IR, they fail to reenter the cell cycle and regenerate the germline in a timely manner. Mechanistically, we identify foxo and mTOR homologue, Tor as important regulators of GSC quiescence following exposure to ionizing radiation...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28924922/assessing-the-non-tumorous-liver-implications-for-patient-management-and-surgical-therapy
#12
Pallavi Pandey, Ankur Pandey, Mary Dillhoff, Carl Schmidt, Ihab R Kamel, Timothy M Pawlik
INTRODUCTION: Hepatic resection is performed for various benign and malignant liver tumors. Over the last several decades, there have been improvements in the surgical technique and postoperative care of patients undergoing liver surgery. Despite this, liver failure following an extended hepatic resection remains a critical potential postoperative complication. Patients with underlying parenchymal liver diseases are at particular risk of liver failure due to impaired liver regeneration with an associated mortality risk as high as 60 to 90%...
September 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28924826/volumetric-and-linear-changes-at-dental-implants-following-grafting-with-volume-stable-three-dimensional-collagen-matrices-or-autogenous-connective-tissue-grafts-6-month-data
#13
Nadja Naenni, Stefan P Bienz, Goran I Benic, Ronald E Jung, Christoph H F Hämmerle, Daniel S Thoma
OBJECTIVES: The objective of this study was to test whether or not soft tissue augmentation with a volume-stable collagen matrix (VCMX) leads to similar volume gain around dental implants compared to autogenous subepithelial connective tissue graft (SCTG). MATERIALS AND METHODS: In 12 adult beagle dogs, immediate implants were placed with simultaneous guided bone regeneration. After 25-45 weeks, soft tissue augmentation was randomly performed using VCMX, SCTG, or a sham-operated control...
September 18, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28924388/spatiotemporal-expression-of-wnt-%C3%AE-catenin-signaling-during-morphogenesis-and-odontogenesis-of-deciduous-molar-in-miniature-pig
#14
Xiaoshan Wu, Yan Li, Fu Wang, Lei Hu, Yang Li, Jinsong Wang, Chunmei Zhang, Songlin Wang
The canonical Wnt/β-catenin signaling pathway has been shown to play essential roles in tooth initiation and early tooth development. However, the role of Wnt/β-catenin signaling in cusp patterning and crown calcification in large mammals are largely unknown. In our previous study, miniature pigs were used as the animal model due to the similarity of tooth anatomy and replacement pattern between miniature pig and human. Dynamic gene expression of third deciduous molar (DM3) in miniature pig at early stages was profiled using microarray method and expression of Wnt genes was significantly correlate with odontogenesis...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28924176/low-carbon-renewable-natural-gas-production-from-coalbeds-and-implications-for-carbon-capture-and-storage
#15
Zaixing Huang, Christine Sednek, Michael A Urynowicz, Hongguang Guo, Qiurong Wang, Paul Fallgren, Song Jin, Yan Jin, Uche Igwe, Shengpin Li
Isotopic studies have shown that many of the world's coalbed natural gas plays are secondary biogenic in origin, suggesting a potential for gas regeneration through enhanced microbial activities. The generation of biogas through biostimulation and bioaugmentation is limited to the bioavailability of coal-derived compounds and is considered carbon positive. Here we show that plant-derived carbohydrates can be used as alternative substrates for gas generation by the indigenous coal seam microorganisms. The results suggest that coalbeds can act as natural geobioreactors to produce low carbon renewable natural gas, which can be considered carbon neutral, or perhaps even carbon negative depending on the amount of carbon sequestered within the coal...
September 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28924014/regenerating-medicine
#16
EDITORIAL
Andrew Webster
No abstract text is available yet for this article.
September 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28923792/p2y2-nucleotide-receptor-prompts-human-cardiac-progenitor-cell-activation-by-modulating-hippo-signaling
#17
Farid G Khalafalla, Steven R Greene, Hashim Khan, Kelli Ilves, Megan M Monsanto, Roberto Alvarez, Monica Chavarria, Jonathan H Nguyen, Benjamin Norman, Walter P Dembitsky, Mark A Sussman
Rationale: Autologous stem cell therapy using human c-Kit(+) cardiac progenitor cells (hCPCs) is a promising therapeutic approach for treatment of heart failure (HF). However, hCPCs derived from aged HF patients with genetic predispositions and/or comorbidities of chronic diseases exhibit poor proliferative and migratory capabilities, which impairs overall reparative potential for injured myocardium. Therefore, empowering functionally compromised hCPCs with pro-regenerative molecules ex vivo is crucial for improving the therapeutic outcome in HF patients...
September 18, 2017: Circulation Research
https://www.readbyqxmd.com/read/28923736/atomic-layered-mn-clusters-deposited-on-palygorskite-as-powerful-adsorbent-for-recovering-valuable-rees-from-wastewater-with-superior-regeneration-stability
#18
Xujian Li, Xing Zhang, Heng Yang, Qi Zhou
The control of dispersity and size of metal particles deposited on substrate surface are always the major challenges for fabricating the efficient and stable metallic nanoparticles-decorated composite. Herein, we proposed a simple liquid-phase atomic layer deposition (L-ALD) method to obtain an atomic-layered MnO2 nanoparticles loaded palygorskite nanorod (MnO2@Pal), involving two-step procedures comprised of the solid-liquid interfacial reaction between organic manganese precursor and surface hydroxyl groups of palygorskite, and then a calcination treatment to activate surface Mn, which is used as a powerful adsorbent for recovery of REE ions from wastewater...
September 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28923600/fungal-strains-isolation-identification-and-application-for-the-recovery-of-zn-ii-ions
#19
Kiran Aftab, Kalsoom Akhtar, Abida Kausar, Shazia Khaliq, Numrah Nisar, Huma Umbreen, Munawar Iqbal
Fungal biomass proves to be highly efficient for the treatment of wastewater as well as recovery of metal ions from wastewater. Present investigation was aimed to evaluate the efficiency of indigenous fungal isolates for the sequestration of Zn(II) ions aqueous solution. Among twenty five fungal isolates, Aspergillus oryzae SV/09 (AO SV/09), Aspergillus flavus NA9 (AF NA9) and Paecilomyces formosus DTO 63f4 (PF DTO-63f4) were identified by gene sequencing of ITS regions of the ribosomal DNA (rDNA). The AO SV/09, AF NA9 and PF DTO-63f4 showed promising efficiency for the biosorption of Zn(II) ions...
September 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28923324/regenerating-heart-using-a-novel-compound-and-human-wharton-jelly-mesenchymal-stem-cells
#20
Shahram Rabbani, Masoud Soleimani, Mohammad Imani, Mohammad Sahebjam, Ali Ghiaseddin, Seyed Mahdi Nassiri, Jalil Majd Ardakani, Maryam Tajik Rostami, Arash Jalali, Bahmanshir Mousanassab, Mahsa Kheradmandi, Seyed Hossein Ahmadi Tafti
BACKGROUND: Myocardial infarction is a major problem in health system and most conventional therapy is not led to restoration of the health. Stem cell therapy is a method to regenerate the heart but today appropriate cell source and scaffold selection as extracellular matrix to achieve the best effect is disputing. AIM OF THE STUDY: In this study a combination of human Wharton jelly mesenchymal stem cells (HWJMSCs) with a novel compound consisting polyethylene glycol (PEG), hyaluronic acid and chitosan is presented to heart regeneration...
April 2017: Archives of Medical Research
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