Kirtishri Mishra, Ilaha Isali, Mohit Sindhani, Megan Prunty, Spencer Bell, Amr Mahran, Giovanni Damiani, Mahmoud Ghannoum, Mauricio Retuerto, Alexander Kutikov, Jonathan Ross, Lynn L Woo, Philip H Abbosh, Laura Bukavina
BACKGROUND: While microbiome and host regulation contribute independently to many disease states, it is unclear how circumcision in pediatric population influences subsequent changes in penile microbiome. OBJECTIVE: Our study aims to analyze jointly paired taxonomic profiles and assess pathways implicated in inflammation, barrier protection, and energy metabolism. DESIGN, SETTING, AND PARTICIPANTS: We analyzed 11 paired samples, periurethral collection, before and after circumcision, to generate microbiome and mycobiome profiling...
December 22, 2022: European Urology Focus