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JOURNAL ARTICLE
Eleen Yang, Mypinder Sekhon, Donald Griesdale
We report a case of a previously healthy early adolescent female who presented with meningococcal meningitis. While in hospital, she had marked neurologic deterioration with clinical herniation from malignant cerebral oedema. She was transferred to a neurocritical care centre where she underwent invasive intracranial pressure (ICP) and brain tissue oxygen (Pbt O2 ) monitoring. Early in her course, she demonstrated a compete absence of autoregulation, with pressure passive cerebral blood flow. As a result, maintaining a mean arterial pressure between 50 mm Hg and 60 mm Hg, which ensured adequate cerebral oxygenation, while avoiding increases in ICP...
November 30, 2022: BMJ Case Reports
#22
Jaime Borràs, Carles Alonso-Tarrés, Alvaro Vives, Juan Palou
Urethritis is an entity characterized by dysuria and purulent urethral discharge, generally acquired sexually. Neisseria gonorrhoeae is one of the most frequently responsible microorganisms. Neisseria meningitidis is a gram-negative diplococcus usually isolated in the pharynx, that occasionally causes meningococcal meningitis, being unusual it's isolation in the anogenital area where it could be a genitourinary pathogen. We present the case of a 25-years-old heterosexual male who, after a heterosexual intercourse with an occasional non-professional partner, including oral and vaginal sex, presented with symptoms of urethritis, orienting to a sexually transmitted infection...
2023: Revista Internacional de Andrología
#23
Charalampos Valmas, Emanuele Arcà, Marja Hensen, Habeeda Rashid
INTRODUCTION: Immunization is the best strategy to protect individuals from invasive meningococcal disease (IMD). To support decision-making around immunization, this paper considers what has led four countries and regions of two more to introduce the quadrivalent MenACWY vaccine in toddlers (ages 12-24 months). AREAS COVERED: A narrative literature review was conducted to identify countries that have introduced a MenACWY vaccination program for toddlers. Information from peer-reviewed publications, reports, and policy documents for each identified country was extracted...
October 12, 2022: Expert Review of Vaccines
#24
JOURNAL ARTICLE
Lucila O Fukasawa, Bernadete L Liphaus, Maria Gisele Gonçalves, Fabio T Higa, Carlos H Camargo, Telma R M P Carvalhanas, Ana Paula S Lemos
Invasive meningococcal disease persists as a fulminant disorder worldwide. Although cases caused by Neisseria meningitidis serogroup X (MenX) occur infrequently, outbreaks have been reported in countries in Africa in recent decades. We report 2 cases of MenX invasive meningococcal disease in São Paulo, Brazil, in 2021 and 2022, during the COVID-19 pandemic.
September 2022: Emerging Infectious Diseases
#25
JOURNAL ARTICLE
Susan Meiring, Cheryl Cohen, Linda de Gouveia, Mignon du Plessis, Vanessa Quan, Jackie Kleynhans, Colin Menezes, Gary Reubenson, Halima Dawood, Maphoshane Nchabeleng, Mohamed Said, Nomonde Mvelase, Prasha Mahabeer, Rispah Chomba, Ruth Lekalakala, Trusha Nana, Vindana Chibabhai, Marianne Black, Anne von Gottberg
OBJECTIVES: Providing country-specific estimates of case fatality and sequelae from bacterial meningitis (BM) is important to evaluate and monitor progress toward the World Health Organization's roadmap to "defeating meningitis by 2030". METHODS: From 2016-2020, GERMS-SA conducted enhanced surveillance at 26 hospitals across South Africa. Episodes of laboratory-confirmed BM due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis were included...
September 2022: International Journal of Infectious Diseases: IJID
#26
JOURNAL ARTICLE
Chien-Shun Chiou, Ying-Shu Liao, Bo-Han Chen, Min-Chi Lu, Yu-Ping Hong, You-Wun Wang, Ru-Hsiou Teng
We present the demographic features of invasive meningococcal disease (IMD) in Taiwan between 1993 and 2020 and the genetic characteristics of Neisseria meningitidis isolates recovered from 2003 to 2020. IMD was rare in Taiwan between 1993 and 2020, with an annual incidence ranging from 0.009 to 0.204 per 100,000 people. The case fatality rate (CFR) declined from 18.1% for patients in 1993 to 2002 to 9.8% in 2003 to 2020. Infants less than 12 months were most susceptible to the disease. N. meningitidis serogroup B (NmB) was most predominant, responsible for 81...
August 31, 2022: Microbiology Spectrum
#27
JOURNAL ARTICLE
Tarek Al-Sanouri, Sabah Mahdi, Ilham Abu Khader, Asaad Mahdi, Alp Dogu, Amine Amiche, Sereen Iweir, Mudhafar Qader, Adel Belbaisi, Riyad AlHilfi
OBJECTIVES: Outbreaks of Neisseria meningitidis have reached alarming levels due to the pathogen's ability to cause severe complications, presenting as meningitis or septicemia. Our study reports the results of the first wide-scale surveillance of meningococcal meningitis in Iraq. METHODS: The study included all consecutive cases of clinically suspected meningitis between June 2018 and May 2020 at 18 major hospitals around Iraq ( n = 2314). Laboratory analysis of biological samples and real-time polymerase chain reaction tests were conducted to confirm bacterial etiology...
December 2021: IJID Reg
#28
JOURNAL ARTICLE
Juan Xu, Yuquan Chen, Mengmeng Yue, Jianxing Yu, Fuyi Han, Li Xu, Zhujun Shao
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis ( Nm ) continues to be a global public health concern. Understanding the prevalence of Nm serogroups in IMD is critical for developing strategies for meningococcal vaccination. We used the keywords "cerebrospinal meningitis", "meningococcal", " Neisseria meningitidis '', "meningococcal meningitis", "serogroup'' and "China'' to search five databases, including PubMed, CNKI, CBM (Chinese BioMedical Literature Database), WanFang and VIP from 2010 to 2020...
November 30, 2022: Human Vaccines & Immunotherapeutics
#29
REVIEW
Selim Badur, Mansour Khalaf, Serdar Öztürk, Rajaa Al-Raddadi, Ashraf Amir, Fayssal Farahat, Atef Shibl
Invasive meningococcal disease (IMD) outbreaks associated with Hajj and Umrah pilgrimage events in the Kingdom of Saudi Arabia (KSA) are well recognized. Past outbreaks have been associated with substantial intercontinental spread of specific Neisseria meningitidis serogroups. The emergence of meningococcal serogroup W (MenW) was a global concern following the 2000/2001 Hajj outbreaks. Broader compulsory meningococcal serogroups A, C, W and Y (MenACWY) immunization strategies for pilgrims were introduced in response to these events and led to substantial declines in IMD cases associated with these mass gatherings...
May 19, 2022: Infectious Diseases and Therapy
#30
JOURNAL ARTICLE
Mariana C Cruz, Paulo Camargos, Cristiana M Nascimento-Carvalho
OBJECTIVE: To evaluate the impact of meningococcal C conjugate (MCC) vaccine in Brazil. METHODS: Ecological study assessing all invasive meningococcal disease (IMD) and meningococcal C disease (MenC) cases reported in all age groups, from 2001 to 2019. MCC was implemented in 2010. Data were collected on the DATASUS platform. Joinpoint regression was performed to assess the annual percent change (APC) of the incidence rate. RESULTS: Invasive meningococcal disease incidence decreased in all Brazilian regions from 2001 onwards, without apparent additional reduction attributable to MCC vaccine in the North, Northeast and South...
March 2022: Tropical Medicine & International Health
#31
REVIEW
Erik Cimé-Aké, Fabián Carranza-Enríquez, José Joel Hurtado-Arias, Wallace Rafael A Muñoz-Castañeda, Benjamín Medina-Fonseca, Ana Barrera-Vargas, María J Lizardo-Thiebaud, Marcela Saeb-Lima, Javier Merayo-Chalico
Primary meningococcal septic arthritis (PMSA) is an extremely rare local infection by Neisseria meningitidis in the absence of meningitis or meningococcaemia syndrome. A 30-year-old healthy, immunocompetent man presented with arthralgia, fever, chest rash, and significant swelling of the right knee. On admission, a disseminated maculopapular and purpuric rash, oligoarthritis, neutrophilia, and elevated acute phase reactants were documented. Following arthrocentesis of the right knee, isolation of N. meningitidis and the presence of calcium oxalate crystals in the synovial fluid were reported...
June 24, 2022: Modern rheumatology case reports
#32
JOURNAL ARTICLE
Gabriel Dapueto, Patricia Barrios, Cristina Zabala, Gabriel Peluffo, Gustavo Giachetto
BACKGROUND: Primary meningococcal arthritis (PMA) is defined as the presence of acute septic arthritis with the identification of Neisseria meningitidis in synovial fluid or blood cultures but no clinical evidence of sepsis or meningitis. This report aimed to describe a clinical case of PMA caused by serogroup W, an uncommon etiology of this disease in Uruguay, and review the available literature. CASE REPORT: We report the case of a 5-year-old female, with no past medical history, admitted to the emergency department with a 12-hour history of fever of 39 °C and a limp...
December 15, 2021: Boletín Médico del Hospital Infantil de México
#33
REVIEW
Serge Mazamay, Jean-François Guégan, Neby Diallo, Didier Bompangue, Eric Bokabo, Jean-Jacques Muyembe, Nadège Taty, Tonton Paul Vita, Hélène Broutin
BACKGROUND: Bacterial meningitis occurs worldwide but Africa remains the most affected continent, especially in the "Meningitis belt" that extends from Senegal to Ethiopia. Three main bacteria are responsible for causing bacterial meningitis, i.e., N. meningitidis (Nm), S. pneumoniae and H. influenzae type b. Among Nm, serogroup A used to be responsible for up to 80 to 85% of meningococcal meningitis cases in Africa. Since 2000, other Nm serogroups including W, X and C have also been responsible for causing epidemics...
September 30, 2021: BMC Infectious Diseases
#34
JOURNAL ARTICLE
Kat Franklin, Brenda Kwambana-Adams, Fernanda C Lessa, Heidi M Soeters, Laura Cooper, Matthew E Coldiron, Jason Mwenda, Martin Antonio, Tomoka Nakamura, Ryan Novak, Adam L Cohen
BACKGROUND: The meningitis belt of sub-Saharan Africa has traditionally experienced large outbreaks of meningitis mainly caused by Neisseria meningitidis. More recently, Streptococcus pneumoniae has been recognized as a cause of meningitis outbreaks in the region. Little is known about the natural history and epidemiology of these outbreaks, and, in contrast to meningococcal meningitis, there is no agreed definition for a pneumococcal meningitis epidemic. The aim of this analysis was to systematically review and understand pneumococcal meningitis outbreaks in Africa between 2000 and 2018...
September 1, 2021: Journal of Infectious Diseases
#35
JOURNAL ARTICLE
Tomoka Nakamura, Adam L Cohen, Stephanie Schwartz, Jason M Mwenda, Goitom Weldegebriel, Joseph N M Biey, Reggis Katsande, Amany Ghoniem, Kamal Fahmy, Hossam Abdel Rahman, Dovile Videbaek, Danni Daniels, Simarjit Singh, Annemarie Wasley, Gloria Rey-Benito, Lucia de Oliveira, Claudia Ortiz, Emmanuel Tondo, Jayantha B L Liyanage, Mohammad Sharifuzzaman, Varja Grabovac, Nyambat Batmunkh, Josephine Logronio, James Heffelfinger, Kimberly Fox, Linda De Gouveia, Anne von Gottberg, Mignon Du Plessis, Brenda Kwambana-Adams, Martin Antonio, Samaa El Gohary, Aya Azmy, Asmaa Gamal, Elena Voropaeva, Ekaterina Egorova, Yulia Urban, Carolina Duarte, Balaji Veeraraghavan, Samir Saha, Ben Howden, Michelle Sait, Sangoun Jung, Songmee Bae, David Litt, Shila Seaton, Mary Slack, Sebastien Antoni, Mahamoudou Ouattara, Chris Van Beneden, Fatima Serhan
BACKGROUND: The World Health Organization (WHO) coordinates the Global Invasive Bacterial Vaccine-Preventable Diseases (IB-VPD) Surveillance Network to support vaccine introduction decisions and use. The network was established to strengthen surveillance and laboratory confirmation of meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. METHODS: Sentinel hospitals report cases of children <5 years of age hospitalized for suspected meningitis...
September 1, 2021: Journal of Infectious Diseases
#36
JOURNAL ARTICLE
Joseph Walker, Heidi M Soeters, Ryan Novak, Alpha Oumar Diallo, Jeni Vuong, Brice Wilfried Bicaba, Isaie Medah, Issaka Yaméogo, Rasmata Ouédraogo-Traoré, Kadidja Gamougame, Daugla Doumagoum Moto, Assétou Y Dembélé, Ibrehima Guindo, Souleymane Coulibaly, Djibo Issifou, Maman Zaneidou, Hamadi Assane, Christelle Nikiema, Adodo Sadji, Katya Fernandez, Jason M Mwenda, Andre Bita, Clément Lingani, Haoua Tall, Félix Tarbangdo, Guetwende Sawadogo, Marietou F Paye, Xin Wang, Lucy A McNamara
Since 2010, the introduction of an effective serogroup A meningococcal conjugate vaccine has led to the near-elimination of invasive Neisseria meningitidis serogroup A disease in Africa's meningitis belt. However, a significant burden of disease and epidemics due to other bacterial meningitis pathogens remain in the region. High-quality surveillance data with laboratory confirmation is important to monitor circulating bacterial meningitis pathogens and design appropriate interventions, but complete testing of all reported cases is often infeasible...
September 1, 2021: Journal of Infectious Diseases
#37
JOURNAL ARTICLE
Xiaomei Li, Dongzhen Chen, Yan Zhang, Xiaojia Xue, Shengyang Zhang, Meng Chen, Xuena Liu, Guoyong Ding
BACKGROUND: Little comprehensive information on overall epidemic trend of notifiable respiratory infectious diseases is available in Shandong Province, China. This study aimed to determine the spatiotemporal distribution and epidemic characteristics of notifiable respiratory infectious diseases. METHODS: Time series was firstly performed to describe the temporal distribution feature of notifiable respiratory infectious diseases during 2005-2014 in Shandong Province...
August 30, 2021: BMC Public Health
#38
REVIEW
Selim Badur, Mona A Al Dabbagh, Atef M Shibl, Fayssal M Farahat, Serdar Öztürk, Debasish Saha, Mansour Khalaf
Reducing invasive meningococcal disease (IMD) through MenACWY immunization is a critical healthcare strategy in the Kingdom of Saudi Arabia (KSA). Robust IMD surveillance is essential to help assess the need for additional immunization initiatives in target populations. This is particularly important in KSA, where mass gatherings accompanying Hajj/Umrah pilgrimages have been associated with IMD outbreaks within the local KSA population, and subsequent intercontinental spread via returning pilgrims. This narrative review of the published literature describes the changing epidemiology of IMD in KSA to provide a perspective on the impact of current immunization strategies and potential gaps...
December 2021: Infectious Diseases and Therapy
#39
JOURNAL ARTICLE
Anastasios Tsakalos, Athanasia Xirogianni, Georgia Ekonomou, Anastasia Papandreou, Efstratios Prokopiou, Eleni Vagiakou, Georgina Tzanakaki
Neisseria meningitidis is considered as an obligate human pathogen and can cause life-threatening diseases like meningitis and/or septicaemia. Occasionally, it can be recovered from infections outside the bloodstream or central nervous system, like respiratory, ocular, joint, urogenital or other unusual sites. Herein, we present two rare cases of female genital infections due to N. meningitidis within a two-year period (2019-2020), identified as serogroup B (MenB) and Y (MenY), respectively. Genotypic analysis for PorA, FetA and MLST revealed the following characteristics: MenB: 7-12, 14, F5-36, 1572cc and MenY: 5-1,10-1, F4-5, 23cc, respectively...
July 14, 2021: Diagnostics
#40
JOURNAL ARTICLE
Supriya Sharma, Jyoti Acharya, Dominique A Caugant, Shreedhar Aryal, Megha Raj Banjara, Prakash Ghimire, Anjana Singh
Because asymptomatic carriers are key source of transmission, information on meningococcal carriage in the community provides a scientific basis for appropriate preventive/control strategies. This longitudinal study (January 2017-December 2019) aimed to estimate carriage rate of meningococci among household contacts of meningococcal meningitis cases within Kathmandu Valley, Nepal. Throat swab samples were collected at first visit from each person in households, twice a month for up to 2 months and subsequently on a monthly basis for a further 4 months...
June 22, 2021: Pathogens
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