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case report meningococcal meningitis

Monique T Barakat, Kiran Gajurel, Katrina Fischer, Kathryn Stevens, Errol Ozdalga, José G Montoya
The clinical spectrum of Neisseria meningitidis can range from nasopharyngeal colonization to life-threatening invasive diseases such as meningitis. However, its etiologic role in invasive pyomyositis (PM) has never been reported before in the English language. In this study, we report the first case of PM in the English language and the second case in the literature caused by N meningitidis.
September 2016: Open Forum Infectious Diseases
Ilaria Izzo, Paola Pileri, Maria Merello, Paolo Gnesin, Enrico Cogi, Carlo Aggiusti, Laura Giacomelli, Stefano Ettori, Paolo Colombini, Andrea Collidá
A young woman was examined in the Emergency Department for fever, pharyngitis and widespread petechial rash. Physical examination, including neurological evaluation, did not show any other abnormalities. Chest X-ray was negative. Blood exams showed leukocytosis and CPR 20 mg/dL (nv<0.5 mg/dL). On the basis of these results and petechial rash evidence, lumbar puncture was performed. CSF was opalescent; physico-chemical examination showed: total proteins 2.8 (nv 0.15-0.45), glucose 5 (nv 59-80), WBC 7600/μL (nv 0-4/ μL)...
September 1, 2016: Le Infezioni in Medicina
Cecilia B Kretz, Adam C Retchless, Fati Sidikou, Bassira Issaka, Sani Ousmane, Stephanie Schwartz, Ashley H Tate, Assimawè Pana, Berthe-Marie Njanpop-Lafourcade, Innocent Nzeyimana, Ricardo Obama Nse, Ala-Eddine Deghmane, Eva Hong, Ola Brønstad Brynildsrud, Ryan T Novak, Sarah A Meyer, Odile Ouwe Missi Oukem-Boyer, Olivier Ronveaux, Dominique A Caugant, Muhamed-Kheir Taha, Xin Wang
In 2015, Niger reported the largest epidemic of Neisseria meningitidis serogroup C (NmC) meningitis in sub-Saharan Africa. The NmC epidemic coincided with serogroup W (NmW) cases during the epidemic season, resulting in a total of 9,367 meningococcal cases through June 2015. To clarify the phylogenetic association, genetic evolution, and antibiotic determinants of the meningococcal strains in Niger, we sequenced the genomes of 102 isolates from this epidemic, comprising 81 NmC and 21 NmW isolates. The genomes of 82 isolates were completed, and all 102 were included in the analysis...
October 2016: Emerging Infectious Diseases
Karolina Akinosoglou, Angelos Alexopoulos, Nikolaos Koutsogiannis, Charalampos Gogos, Aleksandra Lekkou
Meningococcal meningitis is a well established potential fatal infection characterized by fever, headache, petechial rash, and vomiting in the majority of cases. However, protean manifestations including abdominal pain, sore throat, diarrhea and cough, even though rare, should not be overlooked. Similarly, although disseminated infection could potentially involve various organ-targets, secondary immune related complications including joints or pericardium should be dealt with caution, since they remain unresponsive to appropriate antibiotic regimens...
September 12, 2016: Brazilian Journal of Infectious Diseases
Jun Hirai, Takeshi Kinjo, Takaaki Tome, Mao Hagihara, Daisuke Sakanashi, Hideta Nakamura, Shusaku Haranaga, Hiroshige Mikamo, Jiro Fujita
Neisseria meningitidis often causes meningitis and meningococcemia; however, meningococcal pneumonia is quite rare. Herein, we report a case of non-invasive meningococcal pneumonia initially misdiagnosed as pneumonia due to Moraxella catarrhalis on the basis of a Gram stain in a 43-year-old woman with asthma, type 2 diabetes mellitus, and schizophrenia. She visited our hospital following a 3-day history of fever, productive cough, and shortness of breath. Since her sputum smear revealed Gram-negative diplococcus and the chest radiograph showed infiltration in the lower right lung field, her initial diagnosis was pneumonia caused by M...
August 31, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Fati Sidikou, Maman Zaneidou, Ibrahim Alkassoum, Stephanie Schwartz, Bassira Issaka, Ricardo Obama, Clement Lingani, Ashley Tate, Flavien Ake, Souleymane Sakande, Sani Ousmane, Jibir Zanguina, Issaka Seidou, Innocent Nzeyimana, Didier Mounkoro, Oubote Abodji, Xin Wang, Muhamed-Kheir Taha, Jean Paul Moulia-Pelat, Assimawe Pana, Goumbi Kadade, Olivier Ronveaux, Ryan Novak, Odile Ouwe Missi Oukem-Boyer, Sarah Meyer
BACKGROUND: To combat Neisseria meningitidis serogroup A epidemics in the meningitis belt of sub-Saharan Africa, a meningococcal serogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010. We report the first meningitis epidemic in Niger since the nationwide introduction of MACV. METHODS: We compiled and analysed nationwide case-based meningitis surveillance data in Niger. Cases were confirmed by culture or direct real-time PCR, or both, of cerebrospinal fluid specimens, and whole-genome sequencing was used to characterise isolates...
August 23, 2016: Lancet Infectious Diseases
Enrique Chacon-Cruz, Cesar Adrian Martinez-Longoria, Eduardo Llausas-Magana, Antonio Luevanos-Velazquez, Jorge Alejandro Vazquez-Narvaez, Sandra Beltran, Ana Elena Limon-Rojas, Fernando Urtiz-Jeronimo, Jose Luis Castaneda-Narvaez, Francisco Otero-Mendoza, Fernando Aguilar-Del Real, Jesus Rodriguez-Chagoyan, Rosa Maria Rivas-Landeros, Maria Luisa Volker-Soberanes, Rosa Maria Hinojosa-Robles, Patricia Arzate-Barbosa, Laura Karina Aviles-Benitez, Fernando Ivan Elenes-Zamora, Chandra M Becka, Ricardo Ruttimann
OBJECTIVES: Meningococcal meningitis is reported as a rare condition in Mexico. There are no internationally published studies on bacterial causes of meningitis in the country based on active surveillance. This study focuses on finding the etiology of bacterial meningitis in children from nine Mexican Hospitals. METHODS: From January 2010 to February 2013, we conducted a three years of active surveillance for meningitis in nine hospitals throughout Mexico. Active surveillance started at the emergency department for every suspected case, and microbiological studies confirmed/ruled out all potentially bacterial pathogens...
January 2016: Therapeutic Advances in Vaccines
Stephen I Pelton
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is associated with high morbidity and mortality. Although IMD incidence is highest in infants, a second peak occurs in adolescents/young adults. The incidence of IMD and the predominant disease-causing meningococcal serogroups vary worldwide. Epidemiologic data have guided the development of meningococcal vaccines to reduce the IMD burden. In Europe, serogroup C IMD has been substantially reduced since the introduction of a serogroup C conjugate vaccine...
August 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Matthias Vossen, Dieter Mitteregger, Christoph Steininger
Neisseria meningitidis remains the most important cause of bacterial meningitis worldwide, particularly in children and young adults. The second most common and a potentially severe end-organ manifestation of invasive meningococcal disease (excluding systemic sepsis) is meningococcal pneumonia. It occurs in between 5% and 15% of all patients with invasive meningococcal disease and is thus the second most common non-systemic end-organ manifestation. To establish the diagnosis requires a high level of clinical awareness - the incidence is therefore very likely underreported and underestimated...
August 17, 2016: Vaccine
Anju Dinkar, Jitendra Singh, Virendra Atam, Krishna Kumar Sahani, Munna Lal Patel
Neisseria meningitidis most commonly manifests as asymptomatic colonization in the nasopharynx of healthy adolescents and adults. It may rarely present as invasive disease which may be either bacterial meningitis or meningococcal septicaemia. Hereby we report a case presented with fever and rashes, irritability followed by self mutilating behaviour who was diagnosed as a case of invasive meningococcal infection. He responded well to treatment with intravenous ceftriaxone and self mutilating behaviour was subsided completely after treatment...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
Munehisa Fukusumi, Hajime Kamiya, Hideyuki Takahashi, Mizue Kanai, Yushi Hachisu, Takehito Saitoh, Makoto Ohnishi, Kazunori Oishi, Tomimasa Sunagawa
We summarize the epidemiology of Japanese meningococcal disease with serogroup distribution. One hundred seventy-eight meningococcal meningitis cases were reported from April 1999 to March 2013 to the national surveillance system. From April 2013, bacteremia was added to the condition of reporting invasive meningococcal disease (IMD). Since then, 59 IMD cases were reported by the end of 2014. Approximately two thirds of the cases were male and the median age was 56years (range: 0-93years). Only 3% of the cases were <5years old...
July 25, 2016: Vaccine
A Salmon-Rousseau, E Piednoir, V Cattoir, A de La Blanchardière
BACKGROUND: The Hajj is the largest annual mass gathering event in the world, thus favoring the transmission of various infections: 183 different nationalities, high temperatures, coincidence with the start of the flu season in the Northern hemisphere, a long barefoot walk, tent-type accommodation, communal toilet facilities, absence of food control, and sharing of razors. Infections are the first cause of hospital admission, which often occurs in the home country of pilgrims. METHODS: Literature review on PubMed from 1952 to November 2015 on the epidemiology and prevention of infections contracted during the Hajj, using the keywords "Hajj" and "infections"...
May 24, 2016: Médecine et Maladies Infectieuses
Deborah A McMahan, Erika D Pitcher, Mindy R Waldron, Amanda S Billman, Shawn M Richards, Pamela R Pontones, Joan M Duwve
On December 11, 2015, the Fort Wayne-Allen County (Indiana) Department of Health was notified by a local hospital laboratory of a suspected case of meningococcal meningitis based on Gram stain results of cerebrospinal fluid. The county health department interviewed close family members and friends of the patient to establish an infectious period, timeline of events, and possible exposures. Close medical and household contacts were offered chemoprophylaxis (1). This case was associated with an elementary school...
2016: MMWR. Morbidity and Mortality Weekly Report
Jerome Ateudjieu, Beat Stoll, Georges Nguefack-Tsague, Martin Ndinakie Yakum, Marcellin Nimpa Mengouo, Blaise Genton
PURPOSE: A new vaccine against meningitis A was introduced in Africa meningitis belt in 2010. This study was planned to describe the incidence and types of adverse events following immunization (AEFIs) with a new conjugate vaccine against meningitis A (MenAfrivac™) in a Cameroonian vaccination campaign. METHODS: The campaign was conducted in Adamawa and North West regions in December 2012 and the AEFIs enhanced surveillance from December 2012 to January 2013. Incidence rates (IR) of overall and serious AEFIs were estimated as well as AEFI incidence rates by type, age group and region...
May 13, 2016: Pharmacoepidemiology and Drug Safety
Marc Rondy, Djibo Issifou, Alkassoum S Ibrahim, Zaneidou Maman, Goumbi Kadade, Hamidou Omou, Sidikou Fati, Esther Kissling, Sarah Meyer, Olivier Ronveaux
INTRODUCTION: In 2015, a large outbreak of serogroup C meningococcal meningitis hit Niamey, Niger, in response to which a vaccination campaign was conducted late April. Using a case-control study we measured the vaccine effectiveness (VE) of tri - (ACW) and quadrivalent (ACYW) polysaccharide meningococcal vaccines against clinical meningitis among 2-15 year olds in Niamey II district between April 28th and June 30th 2015. METHODS: We selected all clinical cases registered in health centers and conducted a household- vaccination coverage cluster survey (control group)...
2016: PLoS Currents
Sergiu Straticiuc, Ancuta Ignat, Elena Hanganu, Vasile Valeriu Lupu, Alexandru Bogdan Ciubara, Roxana Cretu
INTRODUCTION: Neisseria meningitidis (N. meningitidis) is associated with severe invasive infections such as meningitis and fulminant septicemia. Septic arthritis due to N. meningitidis is rare and bone infections have been reported exceptionally. We report the case of a 1-year old girl who presented with a painful, swollen right knee, accompanied by fever and agitation. Arthrocentesis of the right knee, while patient was under anesthesia, yielded grossly purulent fluid, so we made arthrotomy and drainage...
February 2016: Medicine (Baltimore)
D Martinelli, F Fortunato, R Prato
Meningococcal disease is an acute, severe bacterial infection caused by Neisseria meningitidis. The most common presentations of invasive meningococcal infection (IMD) are meningitis and sepsis, less common pathologic presentations include focal infections. IMD can develop from initial symptoms to death within 24 hours. As many as 20% of survivors have permanent sequelae. Infants < 1 year of age have the highest incidence and adolescents the highest carriage prevalence. In Italy, the incidence of IMD was 0...
2015: Journal of Preventive Medicine and Hygiene
Lucy Qian Li, Sanjay Cheema, Nupur Goel
Group B Streptococcus (GBS) is an infrequent cause of meningitis in adults, usually affecting elderly patients and those with serious underlying disease. It is more commonly recognised as one of the leading aetiological agents of neonatal sepsis following maternally derived infection during pregnancy. We report a case of a previously healthy 26-year-old man who presented with fevers, confusion and headache. Lumbar puncture results were consistent with bacterial meningitis, and blood cultures grew GBS. To the best of our knowledge, our patient represents one of the few reported cases of GBS meningitis in a previously healthy young man...
2016: BMJ Case Reports
D Constenla, A Carvalho, N Alvis Guzmán
Background.  The impact of meningitis outbreaks is substantial. We aim to calculate the costs of meningococcal outbreaks in Brazil and Colombia from the healthcare system perspective. Methods.  A review of the literature was performed on costs associated with meningococcal outbreak in Latin America. Structured interviews capturing information about the use of resources, expenses allocated to treatment of infection, immunization campaigns, and response activities during the outbreak and disease surveillance pre- and postoutbreak were directed at local health authorities in Brazil and Colombia to foster a greater understanding of the economic impact of meningococcal outbreaks...
December 2015: Open Forum Infectious Diseases
Maite Irurzun-Lopez, Ngozi A Erondu, Ali Djibo, Ulla Griffiths, James M Stuart, Katya Fernandez, Olivier Ronveaux, Jean-Bernard Le Gargasson, Bradford D Gessner, Anaïs Colombini
BACKGROUND: The introduction of serogroup A meningococcal conjugate vaccine in the African meningitis belt required strengthened surveillance to assess long-term vaccine impact. The costs of implementing this strengthening had not been assessed. METHODOLOGY: The ingredients approach was used to retrospectively determine bacterial meningitis surveillance costs in Chad and Niger in 2012. Resource use and unit cost data were collected through interviews with staff at health facilities, laboratories, government offices and international partners, and by reviewing financial reports...
February 17, 2016: Vaccine
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