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case report meningococcal meningitis

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https://www.readbyqxmd.com/read/28613408/pre-admission-antibiotics-for-suspected-cases-of-meningococcal-disease
#1
REVIEW
Thambu D Sudarsanam, Priscilla Rupali, Prathap Tharyan, Ooriapadickal Cherian Abraham, Kurien Thomas
BACKGROUND: Meningococcal disease can lead to death or disability within hours after onset. Pre-admission antibiotics aim to reduce the risk of serious disease and death by preventing delays in starting therapy before confirmation of the diagnosis. OBJECTIVES: To study the effectiveness and safety of pre-admission antibiotics versus no pre-admission antibiotics or placebo, and different pre-admission antibiotic regimens in decreasing mortality, clinical failure, and morbidity in people suspected of meningococcal disease...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28592578/bacterial-meningitis-in-finland-1995-2014-a-population-based-observational-study
#2
Aleksandra Polkowska, Maija Toropainen, Jukka Ollgren, Outi Lyytikäinen, J Pekka Nuorti
OBJECTIVES: Bacterial meningitis remains an important cause of morbidity and mortality worldwide. Its epidemiological characteristics, however, are changing due to new vaccines and secular trends. Conjugate vaccines against Haemophilus influenzae type b and Streptococcus pneumoniae (10-valent) were introduced in 1986 and 2010 in Finland. We assessed the disease burden and long-term trends of five common causes of bacterial meningitis in a population-based observational study. METHODS: A case was defined as isolation of S...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28495657/outer-membrane-vesicles-extracted-from-neisseria-meningitidis-serogroup-x-for-prevention-of-meningococcal-disease-in-africa
#3
Reinaldo Acevedo, Caridad Zayas, Gunnstein Norheim, Sonsire Fernández, Barbara Cedré, Yisabel Aranguren, Maribel Cuello, Yaimara Rodriguez, Humberto González, Aleida Mandiarote, Marylin Pérez, Maritza Hernández, Mabel Hernández-Cedeño, Domingo González, Sverre-Henning Brorson, Einar Rosenqvist, Lisbeth Naess, Gro Tunheim, Daniel Cardoso, Luis García
Meningococcal disease is caused mainly by serogroups A, B, C, Y, W of N. meningitidis. However, numerous cases of meningitis caused by serogroup X N. meningitidis (MenX) have recently been reported in several African countries. Currently, there are no licensed vaccines against this pathogen and most of the MenX cases have been caused by meningococci from clonal complex (c.c) 181. Detergent extracted meningococcal outer membrane vesicle (dOMV) vaccines have previously shown to be safe and effective against epidemics of serogroup B meningococcal disease in all age groups...
May 8, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28369827/complement-factor-5-c5-p-a252t-mutation-is-prevalent-in-but-not-restricted-to-sub-saharan-africa-implications-for-the-susceptibility-to-meningococcal-disease
#4
C Franco-Jarava, D Comas, A Orren, M Hernández-González, R Colobran
Complement C5 deficiency (C5D) is a rare primary immunodeficiency associated with recurrent infections, particularly meningitis, by Neisseria species. To date, studies to elucidate the molecular basis of hereditary C5D have included fewer than 40 families, and most C5 mutations (13 of 17) have been found in single families. However, the recently described C5 p.A252T mutation is reported to be associated with approximately 7% of meningococcal disease cases in South Africa. This finding raises the question of whether the mutation may be prevalent in other parts of Africa or other continental regions...
April 1, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27832151/nationwide-trends-in-bacterial-meningitis-before-the-introduction-of-13-valent-pneumococcal-conjugate-vaccine-burkina-faso-2011-2013
#5
Dinanibè Kambiré, Heidi M Soeters, Rasmata Ouédraogo-Traoré, Isaïe Medah, Lassana Sangare, Issaka Yaméogo, Guetawendé Sawadogo, Abdoul-Salam Ouédraogo, Soumeya Hema-Ouangraoua, Lesley McGee, Velusamy Srinivasan, Flavien Aké, Malika Congo-Ouédraogo, Soufian Sanou, Absatou Ky Ba, Ryan T Novak, Chris Van Beneden
BACKGROUND: Following introduction of Haemophilus influenzae type b vaccine in 2006 and serogroup A meningococcal conjugate vaccine in 2010, Streptococcus pneumoniae (Sp) became the leading cause of bacterial meningitis in Burkina Faso. We describe bacterial meningitis epidemiology, focusing on pneumococcal meningitis, before 13-valent pneumococcal conjugate vaccine (PCV13) introduction in the pediatric routine immunization program in October 2013. METHODS: Nationwide population-based meningitis surveillance collects case-level demographic and clinical information and cerebrospinal fluid (CSF) laboratory results...
2016: PloS One
https://www.readbyqxmd.com/read/27703989/a-case-of-meningococcal-pyomyositis-in-an-otherwise-healthy-adult
#6
REVIEW
Monique T Barakat, Kiran Gajurel, Katrina Fischer, Kathryn Stevens, Errol Ozdalga, José G Montoya
The clinical spectrum of Neisseria meningitidis can range from nasopharyngeal colonization to life-threatening invasive diseases such as meningitis. However, its etiologic role in invasive pyomyositis (PM) has never been reported before in the English language. In this study, we report the first case of PM in the English language and the second case in the literature caused by N meningitidis.
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27668905/atypical-clinical-presentation-of-meningococcal-meningitis-a-case-report
#7
Ilaria Izzo, Paola Pileri, Maria Merello, Paolo Gnesin, Enrico Cogi, Carlo Aggiusti, Laura Giacomelli, Stefano Ettori, Paolo Colombini, Andrea Collidá
A young woman was examined in the Emergency Department for fever, pharyngitis and widespread petechial rash. Physical examination, including neurological evaluation, did not show any other abnormalities. Chest X-ray was negative. Blood exams showed leukocytosis and CPR 20 mg/dL (nv<0.5 mg/dL). On the basis of these results and petechial rash evidence, lumbar puncture was performed. CSF was opalescent; physico-chemical examination showed: total proteins 2.8 (nv 0.15-0.45), glucose 5 (nv 59-80), WBC 7600/μL (nv 0-4/ μL)...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27649262/whole-genome-characterization-of-epidemic-neisseria-meningitidis-serogroup-c-and-resurgence-of-serogroup-w-niger-2015
#8
Cecilia B Kretz, Adam C Retchless, Fati Sidikou, Bassira Issaka, Sani Ousmane, Stephanie Schwartz, Ashley H Tate, Assimawè Pana, Berthe-Marie Njanpop-Lafourcade, Innocent Nzeyimana, Ricardo Obama Nse, Ala-Eddine Deghmane, Eva Hong, Ola Brønstad Brynildsrud, Ryan T Novak, Sarah A Meyer, Odile Ouwe Missi Oukem-Boyer, Olivier Ronveaux, Dominique A Caugant, Muhamed-Kheir Taha, Xin Wang
In 2015, Niger reported the largest epidemic of Neisseria meningitidis serogroup C (NmC) meningitis in sub-Saharan Africa. The NmC epidemic coincided with serogroup W (NmW) cases during the epidemic season, resulting in a total of 9,367 meningococcal cases through June 2015. To clarify the phylogenetic association, genetic evolution, and antibiotic determinants of the meningococcal strains in Niger, we sequenced the genomes of 102 isolates from this epidemic, comprising 81 NmC and 21 NmW isolates. The genomes of 82 isolates were completed, and all 102 were included in the analysis...
October 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27631124/neisseria-meningitidis-presenting-as-acute-abdomen-and-recurrent-reactive-pericarditis
#9
Karolina Akinosoglou, Angelos Alexopoulos, Nikolaos Koutsogiannis, Charalampos Gogos, Aleksandra Lekkou
Meningococcal meningitis is a well established potential fatal infection characterized by fever, headache, petechial rash, and vomiting in the majority of cases. However, protean manifestations including abdominal pain, sore throat, diarrhea and cough, even though rare, should not be overlooked. Similarly, although disseminated infection could potentially involve various organ-targets, secondary immune related complications including joints or pericardium should be dealt with caution, since they remain unresponsive to appropriate antibiotic regimens...
November 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27591787/meningococcal-pneumonia-in-japan-a-case-report-and-literature-review
#10
Jun Hirai, Takeshi Kinjo, Takaaki Tome, Mao Hagihara, Daisuke Sakanashi, Hideta Nakamura, Shusaku Haranaga, Hiroshige Mikamo, Jiro Fujita
Neisseria meningitidis often causes meningitis and meningococcemia; however, meningococcal pneumonia is quite rare. Herein, we report a case of non-invasive meningococcal pneumonia initially misdiagnosed as pneumonia due to Moraxella catarrhalis on the basis of a Gram stain in a 43-year-old woman with asthma, type 2 diabetes mellitus, and schizophrenia. She visited our hospital following a 3-day history of fever, productive cough, and shortness of breath. Since her sputum smear revealed Gram-negative diplococcus and the chest radiograph showed infiltration in the lower right lung field, her initial diagnosis was pneumonia caused by M...
December 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27567107/emergence-of-epidemic-neisseria-meningitidis-serogroup-c-in-niger-2015-an-analysis-of-national-surveillance-data
#11
Fati Sidikou, Maman Zaneidou, Ibrahim Alkassoum, Stephanie Schwartz, Bassira Issaka, Ricardo Obama, Clement Lingani, Ashley Tate, Flavien Ake, Souleymane Sakande, Sani Ousmane, Jibir Zanguina, Issaka Seidou, Innocent Nzeyimana, Didier Mounkoro, Oubote Abodji, Xin Wang, Muhamed-Kheir Taha, Jean Paul Moulia-Pelat, Assimawe Pana, Goumbi Kadade, Olivier Ronveaux, Ryan Novak, Odile Ouwe Missi Oukem-Boyer, Sarah Meyer
BACKGROUND: To combat Neisseria meningitidis serogroup A epidemics in the meningitis belt of sub-Saharan Africa, a meningococcal serogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010. We report the first meningitis epidemic in Niger since the nationwide introduction of MACV. METHODS: We compiled and analysed nationwide case-based meningitis surveillance data in Niger. Cases were confirmed by culture or direct real-time PCR, or both, of cerebrospinal fluid specimens, and whole-genome sequencing was used to characterise isolates...
November 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27551428/neisseria-meningitidis-and-streptococcus-pneumoniae-as-leading-causes-of-pediatric-bacterial-meningitis-in-nine-mexican-hospitals-following-3-years-of-active-surveillance
#12
Enrique Chacon-Cruz, Cesar Adrian Martinez-Longoria, Eduardo Llausas-Magana, Antonio Luevanos-Velazquez, Jorge Alejandro Vazquez-Narvaez, Sandra Beltran, Ana Elena Limon-Rojas, Fernando Urtiz-Jeronimo, Jose Luis Castaneda-Narvaez, Francisco Otero-Mendoza, Fernando Aguilar-Del Real, Jesus Rodriguez-Chagoyan, Rosa Maria Rivas-Landeros, Maria Luisa Volker-Soberanes, Rosa Maria Hinojosa-Robles, Patricia Arzate-Barbosa, Laura Karina Aviles-Benitez, Fernando Ivan Elenes-Zamora, Chandra M Becka, Ricardo Ruttimann
OBJECTIVES: Meningococcal meningitis is reported as a rare condition in Mexico. There are no internationally published studies on bacterial causes of meningitis in the country based on active surveillance. This study focuses on finding the etiology of bacterial meningitis in children from nine Mexican Hospitals. METHODS: From January 2010 to February 2013, we conducted a three years of active surveillance for meningitis in nine hospitals throughout Mexico. Active surveillance started at the emergency department for every suspected case, and microbiological studies confirmed/ruled out all potentially bacterial pathogens...
January 2016: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/27449148/the-global-evolution-of-meningococcal-epidemiology-following-the-introduction-of-meningococcal-vaccines
#13
REVIEW
Stephen I Pelton
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is associated with high morbidity and mortality. Although IMD incidence is highest in infants, a second peak occurs in adolescents/young adults. The incidence of IMD and the predominant disease-causing meningococcal serogroups vary worldwide. Epidemiologic data have guided the development of meningococcal vaccines to reduce the IMD burden. In Europe, serogroup C IMD has been substantially reduced since the introduction of a serogroup C conjugate vaccine...
August 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27443594/meningococcal-pneumonia
#14
REVIEW
Matthias Vossen, Dieter Mitteregger, Christoph Steininger
Neisseria meningitidis remains the most important cause of bacterial meningitis worldwide, particularly in children and young adults. The second most common and a potentially severe end-organ manifestation of invasive meningococcal disease (excluding systemic sepsis) is meningococcal pneumonia. It occurs in between 5% and 15% of all patients with invasive meningococcal disease and is thus the second most common non-systemic end-organ manifestation. To establish the diagnosis requires a high level of clinical awareness - the incidence is therefore very likely underreported and underestimated...
August 17, 2016: Vaccine
https://www.readbyqxmd.com/read/27437275/self-mutilating-behaviour-in-severe-meningococcal-infection-an-interesting-association
#15
Anju Dinkar, Jitendra Singh, Virendra Atam, Krishna Kumar Sahani, Munna Lal Patel
Neisseria meningitidis most commonly manifests as asymptomatic colonization in the nasopharynx of healthy adolescents and adults. It may rarely present as invasive disease which may be either bacterial meningitis or meningococcal septicaemia. Hereby we report a case presented with fever and rashes, irritability followed by self mutilating behaviour who was diagnosed as a case of invasive meningococcal infection. He responded well to treatment with intravenous ceftriaxone and self mutilating behaviour was subsided completely after treatment...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27291085/national-surveillance-for-meningococcal-disease-in-japan-1999-2014
#16
Munehisa Fukusumi, Hajime Kamiya, Hideyuki Takahashi, Mizue Kanai, Yushi Hachisu, Takehito Saitoh, Makoto Ohnishi, Kazunori Oishi, Tomimasa Sunagawa
We summarize the epidemiology of Japanese meningococcal disease with serogroup distribution. One hundred seventy-eight meningococcal meningitis cases were reported from April 1999 to March 2013 to the national surveillance system. From April 2013, bacteremia was added to the condition of reporting invasive meningococcal disease (IMD). Since then, 59 IMD cases were reported by the end of 2014. Approximately two thirds of the cases were male and the median age was 56years (range: 0-93years). Only 3% of the cases were <5years old...
July 25, 2016: Vaccine
https://www.readbyqxmd.com/read/27230822/hajj-associated-infections
#17
REVIEW
A Salmon-Rousseau, E Piednoir, V Cattoir, A de La Blanchardière
BACKGROUND: The Hajj is the largest annual mass gathering event in the world, thus favoring the transmission of various infections: 183 different nationalities, high temperatures, coincidence with the start of the flu season in the Northern hemisphere, a long barefoot walk, tent-type accommodation, communal toilet facilities, absence of food control, and sharing of razors. Infections are the first cause of hospital admission, which often occurs in the home country of pilgrims. METHODS: Literature review on PubMed from 1952 to November 2015 on the epidemiology and prevention of infections contracted during the Hajj, using the keywords "Hajj" and "infections"...
October 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/27227736/notes-from-the-field-expanded-chemoprophylaxis-offered-in-response-to-a-case-of-meningococcal-meningitis-in-an-elementary-school-indiana-2015
#18
Deborah A McMahan, Erika D Pitcher, Mindy R Waldron, Amanda S Billman, Shawn M Richards, Pamela R Pontones, Joan M Duwve
On December 11, 2015, the Fort Wayne-Allen County (Indiana) Department of Health was notified by a local hospital laboratory of a suspected case of meningococcal meningitis based on Gram stain results of cerebrospinal fluid. The county health department interviewed close family members and friends of the patient to establish an infectious period, timeline of events, and possible exposures. Close medical and household contacts were offered chemoprophylaxis (1). This case was associated with an elementary school...
May 27, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27174237/incidence-and-types-of-adverse-events-during-mass-vaccination-campaign-with-the-meningococcal-a-conjugate-vaccine-menafrivac%C3%A2-in-cameroon
#19
Jerome Ateudjieu, Beat Stoll, Georges Nguefack-Tsague, Martin Ndinakie Yakum, Marcellin Nimpa Mengouo, Blaise Genton
PURPOSE: A new vaccine against meningitis A was introduced in Africa meningitis belt in 2010. This study was planned to describe the incidence and types of adverse events following immunization (AEFIs) with a new conjugate vaccine against meningitis A (MenAfrivac™) in a Cameroonian vaccination campaign. METHODS: The campaign was conducted in Adamawa and North West regions in December 2012 and the AEFIs enhanced surveillance from December 2012 to January 2013. Incidence rates (IR) of overall and serious AEFIs were estimated as well as AEFI incidence rates by type, age group and region...
May 13, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27158558/vaccine-effectiveness-of-polysaccharide-vaccines-against-clinical-meningitis-niamey-niger-june-2015
#20
Marc Rondy, Djibo Issifou, Alkassoum S Ibrahim, Zaneidou Maman, Goumbi Kadade, Hamidou Omou, Sidikou Fati, Esther Kissling, Sarah Meyer, Olivier Ronveaux
INTRODUCTION: In 2015, a large outbreak of serogroup C meningococcal meningitis hit Niamey, Niger, in response to which a vaccination campaign was conducted late April. Using a case-control study we measured the vaccine effectiveness (VE) of tri - (ACW) and quadrivalent (ACYW) polysaccharide meningococcal vaccines against clinical meningitis among 2-15 year olds in Niamey II district between April 28th and June 30th 2015. METHODS: We selected all clinical cases registered in health centers and conducted a household- vaccination coverage cluster survey (control group)...
April 18, 2016: PLoS Currents
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