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Epidemiology of cancer

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https://www.readbyqxmd.com/read/29224133/epidemiology-of-chronic-hepatitis-b-virus-in-ireland-using-routinely-collected-surveillance-and-administrative-data-2004-2014
#1
Caroline E van Gemert, Niamh Murphy, Tara A Mitchell, Margaret E Hellard, Thornton Thornton
BACKGROUND: Ireland has a low prevalence of chronic hepatitis B virus (HBV) infection; however, there are limited recently published epidemiological data. This study aimed to describe the epidemiology of chronic HBV in Ireland between 2004 and 2014 using routine surveillance data and identify and interrogate additional data sources in Ireland to complement the interpretation of HBV surveillance data. METHODS: Routinely collected passive surveillance data of notified cases of HBV infection were collated for 2004-2014...
December 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29223661/-is-cancer-incidence-different-between-type-2-diabetes-patients-compared-to-non-diabetics-in-hemodialysis-a-study-from-the-rein-registry
#2
Aurélie Le Guillou, Adelaide Pladys, Wahida Kihal, Muriel Siebert, Atman Haddj-Elmrabet, Charlotte Cernon, Anne Bernard, Christophe Charasse, Lise Mandart, Didier Hamel, Tugdual Tanquerel, Bernard Strullu, Christine Richer, Pascale Siohan, Théophile Sawadogo, Juliette Baleynaud, Simona Baluta, Sahar Bayat, Cécile Vigneau
BACKGROUND AND OBJECTIVES: In France, diabetes mellitus is now the second cause of end stage renal disease. In a large previous French national study, we observed that dialyzed diabetics have a significant lower risk of death by cancer. This first study was focused on cancer death but did not investigate cancer incidence. In this context, the aim of this second study was to compare the incidence of cancer in diabetic dialyzed patients compared to non-diabetic dialyzed patients in a French region...
December 6, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29223422/national-trends-in-the-epidemiology-of-malignant-pleural-mesothelioma-a-national-cancer-data-base-study
#3
Sahar A Saddoughi, Zaid M Abdelsattar, Shanda H Blackmon
BACKGROUND: Malignant pleural mesothelioma (MPM) remains an aggressive malignancy that is difficult to cure. However, the treatment paradigm of MPM has evolved, and the national practice patterns are unknown. This study examined the national trends in the epidemiology, national treatment patterns, and survival of patients with this disease. METHODS: We identified all patients (n = 19,134) with MPM from the National Cancer Data Base from 2004 to 2013. We analyzed patient, tumor characteristics, and treatment patterns using descriptive statistics and used Kaplan-Meier and Cox proportional hazards models to estimate survival stratified by the type of therapy administered...
December 6, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29223104/improvement-of-relative-survival-in-elderly-patients-with-acute-myeloid-leukaemia-emerging-from-population-based-cancer-registries-in-switzerland-between-2001-and-2013
#4
Annatina Schnegg-Kaufmann, Anita Feller, Helen Baldomero, Alicia Rovo, Markus G Manz, Michael Gregor, Anna Efthymiou, Mario Bargetzi, Urs Hess, Olivier Spertini, Yves Chalandon, Jakob R Passweg, Georg Stussi, Volker Arndt, Nicolas Bonadies
Acute Myeloid Leukaemia (AML) is a rare and heterogeneous haematological malignancy with increasing incidence in the elderly. We performed a population-based, observational analysis of AML cases reported to the Cantonal Cancer Registries in Switzerland. Data was aggregated by the National Institute for Epidemiology and Cancer Registration and stratified for the two time periods 2001-2007 and 2008-2013. Overall, 2351 new AML cases were registered with a stable age-standardised incidence rate (3.0 [95 CI: 2.8-3...
December 6, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29222247/when-can-we-stop-anticoagulation-in-patients-with-cancer-associated-thrombosis
#5
REVIEW
Agnes Y Y Lee
The optimal duration of anticoagulant therapy in patients with cancer-associated venous thromboembolism (VTE) is unknown. Without well-designed studies evaluating the efficacy, safety, and cost-effectiveness of continuing anticoagulant therapy beyond the acute treatment period of 3 to 6 months, evidence-based recommendations are lacking. Consensus guidelines generally suggest continuing anticoagulation treatment in patients with active cancer or receiving cancer treatment, with periodic reassessment of the risks and benefits...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221275/patterns-of-distant-organ-metastases-in-esophageal-cancer-a-population-based-study
#6
Dashan Ai, Hanting Zhu, Wenjia Ren, Yun Chen, Qi Liu, Jiaying Deng, Jinjun Ye, Jianhong Fan, Kuaile Zhao
Background: Esophageal cancer is the eighth most common cancer worldwide. The prognosis of esophageal cancer patients is dismal, especially those with distant organ metastasis. However, there are few studies describing the patterns of distant metastasis in esophageal cancer systematically. Methods: We gathered the data from Surveillance Epidemiology and End Results (SEER) database between 2010 and 2013. Categorical variables were analyzed by the Pearson Chi square test, and continuous variables were analyzed by the two-sample t test...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221179/marital-status-is-associated-with-superior-survival-in-patients-with-esophageal-cancer-a-surveillance-epidemiology-and-end-results-study
#7
Lijun Du, John J Kim, Binrui Chen, Shuwen Zhu, Ning Dai
The impact of marital status on survival among patients with esophageal cancer has not been evaluated in the U.S. population in depth. The aim of the study was to investigate the impact of marital status on survival among patients diagnosed with esophageal cancer. The Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify patients diagnosed with esophageal cancer between 1973 and 2013. Cox regression analysis was performed to evaluate for association between marital status on both cancer-specific and overall survival...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220728/assessment-of-long-term-exposure-to-airborne-dioxin-and-cadmium-concentrations-in-the-lyon-metropolitan-area-france
#8
T Coudon, H Hourani, C Nguyen, E Faure, F R Mancini, B Fervers, P Salizzoni
Identifying the long-term effects of airborne pollutants requires the computation of the spatial and temporal variability of their concentration in air to estimate the exposure of the population. To estimate exposure levels of individuals in a breast cancer case control study nested in a national prospective cohort, we determine here the differential impact of a variety of cadmium and dioxin sources on urban air over a large urban area and over a period of almost 20years. To that end, we couple an emission model, to estimate dioxin and cadmium atmospheric annual releases, with an urban dispersion model in order to compute pollutant concentration fields at a fine temporal (1h) and spatial (25m) resolution...
December 5, 2017: Environment International
https://www.readbyqxmd.com/read/29219049/role-of-mitochondrial-mechanism-in-chemotherapy-induced-peripheral-neuropathy
#9
Mohammad Waseem, Pooja Kaushik, Heena Tabassum, Suhel Parvez
BACKGROUND: Even though chemotherapeutic regimens shows considerable importance, it may cause progressive, continuing and sometimes irreversible peripheral neuropathy. Chemotherapy induced peripheral neuropathy (CIPN) comprises of sensory abnormalities that are most distress issues. The mechanism associated with CIPN pathogenesis is not completely revealed and is treatment is still questionable. The purpose of this review was to investigate the role of mitochondria in CIPN. METHODS: This review is literature based that describes the mitochondrial mechanism underlying CIPN and the neuropathic complications associated with different antineoplastic agents...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29217518/enhancement-of-mammary-tumor-growth-by-igfbp-3-involves-impaired-t-cell-accumulation
#10
Tiffany Scully, Carolyn Scott, Sue Mei Firth, Lisa M Sedger, John E Pintar, Stephen Twigg, Robert C Baxter
Epidemiological studies show an association between obesity and poor breast cancer prognosis. We previously demonstrated that global IGFBP-3 deficiency, in IGFBP-3-null mice, resulted in a 50% reduction in mammary tumor growth over 3 weeks relative to tumors in wild-type C57BL/6 mice. This growth reduction was ameliorated by high-fat feeding-induced obesity. This study aimed to examine how IGFBP-3 promotes tumor growth by influencing the immune tumor microenvironment in healthy and obese mice. Syngeneic EO771 cells, which lack detectable IGFBP-3 expression, were grown as orthotopic tumors in wild-type and IGFBP-3-null C57BL/6 mice placed on either a control chow or high-fat diet, and examined by quantitative PCR and immunohistochemistry...
December 7, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29216960/estimation-study-of-new-cancer-cases-and-deaths-in-wuwei-hexi-corridor-region-china-2018
#11
Bo Yu Cao, Cheng Yun Li, Feng Lan Xu, Xiao Qin Liu, Yan Xu Yang, Jing Li, Cai Yun Gao, You Ming Rong, Rong Cheng Li, Ya Li Li, Shan Zheng, Ya Na Bai, Yan Cheng Ye
Population-based cancer registration data were collected to estimate the cancer incidence and mortality in Wuwei, Hexi Corridor Region, China in 2018. We used the 2011-2013 data to predict the number of new cases and deaths in 2018 and the 2003-2013 data to analyze trends in cancer incidence and mortality. The goal is to enable cancer prevention and control directions. Our results indicated that stomach cancer is the most common cancer. For all cancers combined, the incidence and mortality rates showed significantly increasing trends (+2...
November 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29216556/influence-of-water-activity-and-temperature-on-growth-and-fumonisin-production-by-fusarium-proliferatum-strains-on-irradiated-wheat-grains
#12
Eugenia Cendoya, María Del Pilar Monge, Stella Maris Chiacchiera, María Cecilia Farnochi, María Laura Ramirez
Wheat is the most important cereal consumed by the Argentine population. In previous studies performed in durum and common wheat grains in this country it has been observed fumonisin contamination as well as high incidence of Fusarium proliferatum. Fumonisins are toxic fungal metabolites, and consumption of fumonisin-contaminated maize has been epidemiologically associated with oesophageal cancer and neural tube defects in some human populations. Using irradiated wheat-grains, the effects of abiotic factors, temperature (15, 25, and 30°C) and water activity (aW; 0...
December 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29216521/the-use-of-palliative-medications-before-death-from-prostate-cancer-swedish-population-based-study-with-a-comparative-overview-of-european-data
#13
Magdalena Lycken, Linda Drevin, Hans Garmo, Pär Stattin, Jan Adolfsson, Ingela Franck Lissbrant, Lars Holmberg, Anna Bill-Axelson
BACKGROUND: Symptoms of terminal cancer have previously been reported as undertreated. The aim of this study was to assess the use of palliative medications before death from prostate cancer. METHODS: This Swedish register study included men who died from 2009 to 2012 with prostate cancer as the underlying cause of death. We assessed the proportion who collected a prescription of androgen deprivation therapy, non-steroidal anti-inflammatory drugs, paracetamol, opioids, glucocorticoids, antidepressants, anxiolytics and sedative-hypnotics and the differences in treatment related to age, time since diagnosis, educational level, close relatives and comorbidities...
December 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29212805/when-can-we-stop-anticoagulation-in-patients-with-cancer-associated-thrombosis
#14
Agnes Y Y Lee
The optimal duration of anticoagulation in patients with cancer-associated venous thromboembolism (VTE) is unknown. Without well-designed studies evaluating the efficacy, safety and cost-effectiveness of continuing anticoagulant therapy beyond the acute treatment period of 3 to 6 months, evidence-based recommendations are lacking. Consensus guidelines generally suggest continuing anticoagulation in patients with active cancer or receiving cancer treatment, with periodic reassessment of the risks and benefits...
December 6, 2017: Blood
https://www.readbyqxmd.com/read/29212195/the-adaptive-immune-system-promotes-initiation-of-prostate-carcinogenesis-in-a-human-c-myc-transgenic-mouse-model
#15
Monique H M Melis, Ekaterina Nevedomskaya, Johan van Burgsteden, Bianca Cioni, Hester J T van Zeeburg, Ji-Ying Song, John Zevenhoven, Lukas J A C Hawinkels, Karin E de Visser, Andries M Bergman
Increasing evidence from epidemiological and pathological studies suggests a role of the immune system in the initiation and progression of multiple cancers, including prostate cancer. Reports on the contribution of the adaptive immune system are contradictive, since both suppression and acceleration of disease development have been reported. This study addresses the functional role of lymphocytes in prostate cancer development using a genetically engineered mouse model (GEMM) of human c-Myc driven prostate cancer (Hi-Myc mice) combined with B and T cell deficiency (RAG1-/- mice)...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211900/racial-ethnic-differences-in-the-epidemiology-of-ovarian-cancer-a-pooled-analysis-of-12-case-control-studies
#16
Lauren C Peres, Harvey Risch, Kathryn L Terry, Penelope M Webb, Marc T Goodman, Anna H Wu, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa L Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Edward S Peters, Ann G Schwartz, Paul D Terry, Ani Manichaikul, Sarah E Abbott, Fabian Camacho, Susan J Jordan, Christina M Nagle, Mary Anne Rossing, Jennifer A Doherty, Francesmary Modugno, Kirsten Moysich, Roberta Ness, Andrew Berchuck, Linda Cook, Nhu Le, Angela Brooks-Wilson, Weiva Sieh, Alice Whittemore, Valerie McGuire, Joseph Rothstein, Hoda Anton-Culver, Argyrios Ziogas, Celeste L Pearce, Chiuchen Tseng, Malcom Pike, Joellen M Schildkraut
Background: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. Methods: We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders)...
December 2, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29211739/the-association-between-socioeconomic-factors-and-breast-cancer-specific-survival-varies-by-race
#17
Shailesh Agarwal, Jian Ying, Kenneth M Boucher, Jayant P Agarwal
Although racial disparity is well described for oncologic outcomes, factors associated with survival within racial groups remains unexplored. The objective of this study is to determine whether breast cancer survival among White or Black patients is associated with differing patient factors. Women diagnosed with breast cancer from 1998 through 2012 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Cox proportional hazard logistic regression was used to estimate cause-specific survival in the combined cohort, and separate cohorts of Black or White patients only...
2017: PloS One
https://www.readbyqxmd.com/read/29211715/alcohol-abuse-drug-disulfiram-targets-cancer-via-p97-segregase-adaptor-npl4
#18
Zdenek Skrott, Martin Mistrik, Klaus Kaae Andersen, Søren Friis, Dusana Majera, Jan Gursky, Tomas Ozdian, Jirina Bartkova, Zsofia Turi, Pavel Moudry, Marianne Kraus, Martina Michalova, Jana Vaclavkova, Petr Dzubak, Ivo Vrobel, Pavla Pouckova, Jindrich Sedlacek, Andrea Miklovicova, Anne Kutt, Jing Li, Jana Mattova, Christoph Driessen, Q Ping Dou, Jørgen Olsen, Marian Hajduch, Boris Cvek, Raymond J Deshaies, Jiri Bartek
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also known by the trade name Antabuse), an old alcohol-aversion drug that has been shown to be effective against diverse cancer types in preclinical studies. Our nationwide epidemiological study reveals that patients who continuously used disulfiram have a lower risk of death from cancer compared to those who stopped using the drug at their diagnosis...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29211313/comparative-study-of-lung-and-extrapulmonary-poorly-differentiated-neuroendocrine-carcinomas-a-seer-database-analysis-of-162-983-cases
#19
Arvind Dasari, Kathan Mehta, Lauren A Byers, Halfdan Sorbye, James C Yao
BACKGROUND: Extrapulmonary neuroendocrine carcinomas (NECs) are poorly studied and are managed similar to lung NECs, which may not account for differences between the 2 groups of tumors as well as the heterogeneity within extrapulmonary NEC. METHODS: Data from the Surveillance, Epidemiology, and End Results program between 1973 and 2012 were used to estimate the relative percentages of lung NECs and subgroups of extrapulmonary NECs, epidemiological patterns at these sites, and the median and 5-year overall survival rates...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29210800/molecular-modifiers-of-hormone-receptor-action-decreased-androgen-receptor-expression-in-mismatch-repair-deficient-endometrial-endometrioid-adenocarcinoma
#20
Qiong Gan, Suzanne Crumley, Russell R Broaddus
Endometrial endometrioid carcinoma is related to estrogen excess and expression of estrogen and progesterone receptors. Epidemiological evidence suggests that exposure to elevated androgens, as in polycystic ovarian syndrome, increases the risk of endometrial cancer. Factors impacting androgen receptor (AR) expression are not well studied. Mismatch repair (MMR) deficiency due to MLH1 gene methylation is one of the most common molecular alterations in endometrial cancer, occurring in 15% to 20% of cases. MLH1 methylation can be associated with decreased expression of other genes, so we examined the effect of MMR status on AR expression...
November 28, 2017: International Journal of Gynecological Pathology
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