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https://www.readbyqxmd.com/read/29912394/circulating-vitamin-d-and-colorectal-cancer-risk-an-international-pooling-project-of-17-cohorts
#1
Marjorie L McCullough, Emilie S Zoltick, Stephanie J Weinstein, Veronika Fedirko, Molin Wang, Nancy R Cook, A Heather Eliassen, Anne Zeleniuch-Jacquotte, Claudia Agnoli, Demetrius Albanes, Matthew J Barnett, Julie E Buring, Peter T Campbell, Tess V Clendenen, Neal D Freedman, Susan M Gapstur, Edward L Giovannucci, Gary G Goodman, Christopher A Haiman, Gloria Y F Ho, Ronald L Horst, Tao Hou, Wen-Yi Huang, Mazda Jenab, Michael E Jones, Corinne E Joshu, Vittorio Krogh, I-Min Lee, Jung Eun Lee, Satu Männistö, Loic Le Marchand, Alison M Mondul, Marian L Neuhouser, Elizabeth A Platz, Mark P Purdue, Elio Riboli, Trude Eid Robsahm, Thomas E Rohan, Shizuka Sasazuki, Minouk J Schoemaker, Sabina Sieri, Meir J Stampfer, Anthony J Swerdlow, Cynthia A Thomson, Steinar Tretli, Schoichiro Tsugane, Giske Ursin, Kala Visvanathan, Kami K White, Kana Wu, Shiaw-Shyuan Yaun, Xuehong Zhang, Walter C Willett, Mitchel H Gail, Regina G Ziegler, Stephanie A Smith-Warner
Background: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize risk are unknown. Current Institute of Medicine (IOM) vitamin D guidance is based solely on bone health. Methods: We pooled participant-level data from 17 cohorts, comprising 5706 colorectal cancer case participants and 7107 control participants with a wide range of circulating 25(OH)D concentrations...
June 14, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29912384/a-bayesian-approach-to-investigate-life-course-hypotheses-involving-continuous-exposures
#2
Sreenath Madathil, Lawrence Joseph, Rebecca Hardy, Marie-Claude Rousseau, Belinda Nicolau
Background: Different hypotheses have been proposed in life course epidemiology on how a time-varying exposure can affect health or disease later in life. Researchers are often interested in investigating the probability of these hypotheses based on observed life course data. However, current techniques based on model/variable selection do not provide a direct estimate of this probability. We propose an alternative technique for a continuous exposure, using a Bayesian approach that has specific advantages, to investigate which life course hypotheses are supported by the observed data...
June 14, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29911922/positive-association-between-hypertension-and-urinary-bladder-cancer-epidemiologic-evidence-involving-79-236-propensity-score-matched-individuals
#3
Victor C Kok, Han-Wei Zhang, Chin-Teng Lin, Shih-Chung Huang, Ming-Feng Wu
INTRODUCTION: We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer. MATERIAL AND METHODS: We performed a population-based cohort study on adults using a National Health Insurance Research Database (NHIRD) dataset. Hypertension and comparison non-hypertensive (COMP) groups comprising 39,618 patients each were propensity score-matched by age, sex, index date, and medical comorbidities. The outcome was incident UB cancer validated using procedure codes...
June 18, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29911113/survival-outcomes-for-advanced-kidney-cancer-patients-in-the-era-of-targeted-therapies
#4
Arpit Rao, Charles Wiggins, Richard C Lauer
Background: Advanced renal cell carcinoma (RCC) results in over 14,000 deaths each year in the United States alone. The therapeutic landscape for advanced RCC changed dramatically with the approval of tyrosine kinase inhibitors (TKI) between 2006 and 2012. A large-scale analysis of survival trends has not been performed in the TKI era to determine their impact on outcomes for advanced RCC patients. Methods: The Surveillance, Epidemiology and End-Results (SEER) database was queried for adult patients with advanced RCC diagnosed between 2000 and 2013...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29909908/the-epidemiology-of-oral-human-papillomavirus-infection-in-healthy-populations-a-systematic-review-and-meta-analysis
#5
REVIEW
Samantha Tam, Shuangshuang Fu, Li Xu, Kate J Krause, David R Lairson, Hongyu Miao, Erich M Sturgis, Kristina R Dahlstrom
Human papillomavirus (HPV) is a potentially oncogenic sexually transmitted infection. As the incidence of oropharyngeal cancer (OPC) caused by oral HPV infections is rising, further investigation into the natural history of such infections is needed. This systematic review and meta-analysis aimed to synthesize data on the prevalence, incidence, clearance, and persistence of oral HPV infections in healthy individuals. A systematic review of literature published between January 1995 and August 2017 was conducted using Ovid MEDLINE, PubMed, Embase, and the Cochrane Library...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29908246/refractory-ceramic-fibers-fiber-characteristics-potential-health-effects-and-clinical-observations
#6
Mark J Utell, L Daniel Maxim
Refractory ceramic fibers (RCFs) are amorphous fibers that belong to a class of materials termed synthetic vitreous fibers (SVFs), also called man-made mineral fibers (MMMFs), which includes alkaline earth silicate wool, glass wool, rock (stone) wool, slag wool, and special-purpose glass fibers. RCFs are more durable and biopersistent than several other SVFs, although very much less biopersistent than either amosite or crocidolite asbestos. Chronic inhalation studies indicated that rats and hamsters exposed to RCF fibers developed fibrosis and tumors...
June 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29907942/distribution-of-21-gene-recurrence-scores-in-male-breast-cancer-in-the-united-states
#7
Ariella M Altman, Scott Kizy, Jianling Yuan, Jason W Denbo, Eric H Jensen, Jane Y C Hui, Todd M Tuttle, Schelomo Marmor
BACKGROUND: The 21-gene recurrence score (RS) is a RT-PCR assay estimating risk of distant recurrence in estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2) breast cancer (BC). Studies validating RS are limited to women. Our objective was to assess RS distribution and factors associated with high-risk RS in male BC. METHODS: Using the Surveillance, Epidemiology, and End Results database, we identified men and women with ER+/HER2- BC from 2010 to 2013...
June 15, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29907746/colorectal-cancer-associated-streptococcus-infantarius-subsp-infantarius-differ-from-a-major-dairy-lineage-providing-evidence-for-pathogenic-pathobiont-and-food-grade-lineages
#8
Dasel Wambua Mulwa Kaindi, Wambui Kogi-Makau, Godfrey Nsereko Lule, Bernd Kreikemeyer, Pierre Renault, Bassirou Bonfoh, Nize Otaru, Thomas Schmid, Leo Meile, Jan Hattendorf, Christoph Jans
Streptococcus infantarius subsp. infantarius (Sii), a member of the Streptococcus bovis/Streptococcus equinus complex (SBSEC), predominates as dairy-adapted and non-adapted variants in fermented dairy products (FDP) in East and West Africa. Epidemiologic data suggest an association with colorectal cancer for most SBSEC members, including Sii from Kenyan patients. Phylogenetic relationships of East African human (EAH) isolates to those of dairy and pathogenic origin were analysed to better estimate potential health implications via FDP consumption...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907221/racial-ethnic-disparities-in-the-adjuvant-chemotherapy-of-locally-advanced-colon-cancer-patients
#9
Xi Zhong, Zhexu Guo, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Yu Sun, Zhenning Wang
BACKGROUND: Most race/ethnicity-oriented investigations focus on Caucasian Americans (whites) and African Americans (blacks), leaving Asians, Hispanic white (Hispanics), and other minorities less well studied. Adjuvant chemotherapy (CT) after curative resection is critical to patients with locally advanced colon cancer (LACC). We studied the racial disparities in the adjuvant CT of LACC to aid in selecting optimal treatments for people from different races/ethnicities in this era of precision medicine...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906615/studying-a-rare-disease-using-multi-institutional-research-collaborations-vs-big-data-where-lies-the-truth
#10
Aileen C Johnson, Cecilia G Ethun, Yuan Liu, Alexandra G Lopez-Aguiar, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Keith A Delman, William C Wood, Kenneth Cardona, Shishir K Maithel
BACKGROUND: Multi-institutional collaborations provide granularity lacking in epidemiologic datasets to enable in-depth study of rare diseases. For pts with superficial, high-grade soft tissue sarcomas (STS) of the trunk/extremity, the value of radiation therapy (RT) is not clear. We aimed to utilize the 7-institution US-Sarcoma-Collaborative (USSC) and the National Cancer Database (NCDB) to investigate this issue. STUDY DESIGN: All adult pts with superficial truncal/extremity high-grade STS who underwent primary curative-intent resection from 2000-2016 at USSC institutions or were included in the NCDB from 2004-2013 were analyzed...
June 12, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29906298/synthesis-cox-1-2-inhibition-and-antioxidant-activities-of-new-oxicam-analogues-designed-as-potential-chemopreventive-agents
#11
Berenika Szczęśniak-Sięga, Katarzyna Gębczak, Tomasz Gębarowski, Jadwiga Maniewska
Oxicams (e.g. piroxicam, meloxicam) are widely used nonsteroidal anti-inflammatory drugs (NSAIDs). A large body of evidence from epidemiological and preclinical studies has shown that NSAIDs have a chemopreventive effect on different types of cancer, especially in colorectal cancer. Moreover, mounting evidence from preclinical and clinical studies suggests that persistent inflammation functions as a driving force in the journey to cancer. What is more, inflammation induces reactive oxygen and nitrogen species, which cause damage to important cellular components (e...
June 15, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29906273/breast-cancer-risk-markedly-lower-with-serum-25-hydroxyvitamin-d-concentrations-%C3%A2-60-vs-20-ng-ml-150-vs-50-nmol-l-pooled-analysis-of-two-randomized-trials-and-a-prospective-cohort
#12
Sharon L McDonnell, Carole A Baggerly, Christine B French, Leo L Baggerly, Cedric F Garland, Edward D Gorham, Bruce W Hollis, Donald L Trump, Joan M Lappe
BACKGROUND: While numerous epidemiologic studies have found an association between higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and lower breast cancer risk, few have assessed this association for concentrations >40 ng/ml. OBJECTIVE: To investigate the relationship between 25(OH)D concentration and breast cancer risk across a broad range of 25(OH)D concentrations among women aged 55 years and older. METHODS: Analyses used pooled data from two randomized clinical trials (N = 1129, N = 2196) and a prospective cohort (N = 1713) to examine a broad range of 25(OH)D concentrations...
2018: PloS One
https://www.readbyqxmd.com/read/29906025/malignant-tumors-as-cause-of-disability-at-the-instituto-mexicano-del-seguro-social
#13
Edgar Jesús Zitle-García, Alma Lucila Sauceda-Valenzuela, Iván de Jesús Ascencio-Montiel, Jesús García-Paredes
Background: Cancer represents an important issue in health, with the economic impact that it takes. The aim of this paper is to analyze the epidemiological characteristics of a population with social security who was diagnosed with some type of cancer and required a disability pension. Methods: Observational study, retrolective cohort type, carried out at the Instituto Mexicano del Seguro Social (IMSS) with IMSS beneficiaries ruled with a state of disability due to malignancy during the period 2006 to 2012...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905908/natural-history-of-barrett-s-esophagus
#14
REVIEW
Ernst J Kuipers, Manon C Spaander
Barrett's esophagus (BE) is a very common condition. We have obtained fairly profound knowledge of the natural history of this condition. This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent to use their clinical data has improved our knowledge to the benefit of these same and other patients. The prevalence of BE increases with age both in men and in women. This increase starts at a younger age in men than in women. The incidence of high-grade dysplasia and cancer in BE depends on segment length, gender, and age...
June 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29905376/a-prospective-study-of-dietary-polyunsaturated-fatty-acids-intake-and-lung-cancer-risk
#15
Hung N Luu, Hui Cai, Harvey J Murff, Yong-Bing Xiang, Qiuyin Cai, Honglan Li, Jing Gao, Gong Yang, Qing Lan, Yu-Tang Gao, Wei Zheng, Xiao-Ou Shu
Animal studies have shown that polyunsaturated fatty acids (PUFAs) have antineoplastic and anti-inflammatory properties. Results from epidemiologic studies on specific types of PUFAs for lung cancer risk, however, are inconclusive. We prospectively evaluated the association of specific types of dietary PUFA intakes and lung cancer risk in two population-based cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS) with a total of 121,970 study participants (i.e., 65,076 women and 56,894 men)...
June 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29904742/factors-influencing-prostate-cancer-patterns-of-care-an-analysis-of-treatment-variation-using-the-seer-database
#16
Lindsay M Burt, Dennis C Shrieve, Jonathan D Tward
Purpose: The aim of this study is to describe the trends and factors that influence the initial treatment of men with localized prostate cancer (PC) in the United States between 2004 and 2014. Methods and materials: The National Cancer Institute's Surveillance, Epidemiology and End Results database was used to identify patients with primary prostate adenocarcinoma between 2004 and 2014. Patients were staged in accordance with the American Joint Committee on Cancer 7th edition criteria and stratified according to the National Comprehensive Cancer Network guidelines risk group classification...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904731/the-pervasive-crisis-of-diminishing-radiation-therapy-access-for-vulnerable-populations-in-the-united-states-part-3-hispanic-american-patients
#17
Shearwood McClelland, Carmen A Perez
Purpose: Health disparities have profoundly affected underrepresented minorities throughout the United States, particularly with regard to access to evidence-based interventions such as surgery or medication. The degree of disparity in access to radiation therapy (RT) for Hispanic-American patients with cancer has not been previously examined in an extensive manner. Methods and materials: An extensive literature search was performed using the PubMed database to examine studies investigating disparities in RT access for Hispanic-Americans...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904587/indole-3-carbinol-a-plant-hormone-combatting-cancer
#18
REVIEW
Ella Katz, Sophia Nisani, Daniel A Chamovitz
A diet rich in cruciferous vegetables such as cauliflower, broccoli, and cabbage has long been considered healthy, and various epidemiological studies suggest that the consumption of cruciferous vegetables contributes to a cancer-protecting diet. While these vegetables contain a vast array of phytochemicals, the mechanism by which these vegetables counteract cancer is still largely unresolved. Numerous in situ studies have implicated indole-3-carbinol, a breakdown product of the glucosinolate indole-3-ylmethylglucosinolate, as one of the phytochemicals with anti-cancer properties...
2018: F1000Research
https://www.readbyqxmd.com/read/29904446/secondary-salivary-gland-malignancy-in-thyroid-cancer-a-united-states-population-based-study
#19
Eliza Sharma, Suyash Dahal, Pratibha Sharma, Abani Bhandari, Vishal Gupta, Sumit Dahal
Background: There is an increased risk of second primary malignancies with thyroid cancer. However, the risk and characters of secondary salivary gland malignancy (sSGM) in patients with thyroid cancer have not been evaluated before. Methods: We used the Surveillance Epidemiology and End Results (SEER) 18 registry to identify thyroid cancer patients from 1973 to 2014. We then calculated the risk of sSGM using standardized incidence ratio and excess risk. Separately, all cases of primary salivary gland malignancy (pSGM) diagnosed between 1973 - 2014 were extracted from the SEER 18 registry, and their characteristics compared with sSGM using independent samples t -test for continuous variables and Chi-square tests for categorical variables...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904247/stage-iii-should-be-subclassified-into-stage-iiia-and-iiib-in-the-american-joint-committee-on-cancer-8-th-edition-staging-system-for-pancreatic-cancer
#20
Hai-Feng Yu, Bing-Qing Zhao, Yong-Cheng Li, Jun Fu, Wei Jiang, Rong-Wei Xu, Hao-Chang Yang, Xiao-Jun Zhang
AIM: To ascertain the prognostic role of the T4 and N2 category in stage III pancreatic cancer according to the 8th edition of the American Joint Committee on Cancer (AJCC) classification. METHODS: Patients were collected from the Surveillance Epidemiology and End Results (SEER) database (2004-2013) and were divided into three groups: T(1-3)N2, T4N(0-1), and T4N2. Overall survival (OS) and disease-specific survival (DSS) of patients were evaluated by the Kaplan-Meier method...
June 14, 2018: World Journal of Gastroenterology: WJG
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