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duplex collecting system

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https://www.readbyqxmd.com/read/29322505/impact-of-bistrand-abasic-sites-and-proximate-orientation-on-dna-global-structure-and-duplex-energetics
#1
Conceição A Minetti, Jeffrey Y Sun, Daniel P Jacobs, Inkoo Kang, David P Remeta, Kenneth J Breslauer
Bistrand lesions embedded within a single helical turn of tridecameric deoxyoligonucleotide duplexes represent a model system for exploring the impact of clustered lesions that occur in vivo and pose a significant challenge to cellular repair machineries. Such investigations are essential for understanding the forces that dictate lesion-induced mutagenesis, carcinogenesis, and cytotoxicity within a context that mimics local helical perturbations caused by an ionizing radiation event. This study characterizes the structural and energy profiles of DNA duplexes harboring synthetic abasic sites (tetrahydrofuran, F) as models of clustered bistrand abasic (AP) lesions...
January 11, 2018: Biopolymers
https://www.readbyqxmd.com/read/29290905/duplex-collecting-system-in-a-pelvic-kidney-an-unusual-combination
#2
Francesca Giorlando, Chiara Recaldini, Anna Leonardi, Edoardo Macchi, Carlo Fugazzola
Pelvic kidney is a relatively common renal malformation as well as duplex kidney; however, the unilateral coexistence of these abnormalities is not frequently found. We present a case of a young woman with a history of hypertension in whom a pelvic and dysmorphic left kidney was discovered during ultrasound examination performed for the study of the renal arteries. Magnetic resonance imaging and computed tomography imaging revealed a duplex pelvic kidney. This combination is very rare; we have not found a similar case reported in the literature...
December 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29224026/heminephrectomy-in-adults-a-systematic-review-with-cumulative-analysis
#3
Keiran Clement, Jane Hendry, Francis X Keeley, Omar M Aboumarzouk
INTRODUCTION: Duplex collecting system of the kidney is a relatively common abnormality, with the majority of symptomatic cases discovered in childhood. Treatment is commonly a heminephrectomy of the affected moiety. We aimed to conduct a systematic review of the literature to provide the best available evidence for heminephrectomy for duplex kidneys in the adult population. MATERIALS AND METHODS: A literature search was conducted in September 2017 with no limitations being placed on language, region, date or publication type...
December 8, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29191963/competitive-apnea-and-its-effect-on-the-human-brain-focus-on-the-redox-regulation-of-blood-brain-barrier-permeability-and-neuronal-parenchymal-integrity
#4
Anthony R Bain, Philip N Ainslie, Ryan L Hoiland, Otto F Barak, Ivan Drvis, Mike Stembridge, Douglas M MacLeod, Jane McEneny, Benjamin S Stacey, Eduoard Tuaillon, Nicola Marchi, Alexis Fayd'Herbe De Maudave, Zeljko Dujic, David B MacLeod, Damian M Bailey
Static apnea provides a unique model that combines transient hypertension, hypercapnia, and severe hypoxemia. With apnea durations exceeding 5 min, the purpose of the present study was to determine how that affects cerebral free-radical formation and the corresponding implications for brain structure and function. Measurements were obtained before and following a maximal apnea in 14 divers with transcerebral exchange kinetics, measured as the product of global cerebral blood flow (duplex ultrasound) and radial arterial to internal jugular venous concentration differences (a-vD)...
November 30, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29073517/quantitative-detection-of-exosomal-microrna-extracted-from-human-blood-based-on-surface-enhanced-raman-scattering
#5
Dandan Ma, Caixia Huang, Jing Zheng, Jianru Tang, Jishan Li, Jinfeng Yang, Ronghua Yang
Since the nature of the exosomal lipid bilayer can allow miRNAs to be protected from degradation by cellular RNAses in body fluids, exosomal microRNA (miRNA) has become an ideal source of non-invasive biomarkers for the early diagnosis and prognosis. In this paper, a new surface-enhanced Raman scattering (SERS) analysis strategy combining stable SERS reporter element and duplex-specific nuclease (DSN)-assisted signal amplification for quantitative detection of exosomal miRNA extracted from human blood is proposed...
October 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29073174/asthma-is-associated-with-atherosclerotic-artery-changes
#6
COMPARATIVE STUDY
Izabela Tuleta, Dirk Skowasch, Florian Aurich, Nicolas Eckstein, Robert Schueler, Carmen Pizarro, Nadjib Schahab, Georg Nickenig, Christian Schaefer, Simon Pingel
Asthma is a chronic airway inflammation with a potential systemic impact. Atherosclerosis is a chronic inflammatory artery disease. The aim of our study was to prove if there is a correlation between the occurrence of asthma and increased atherosclerotic vessel disorders. Vessel status was compared between mild-to-moderate, severe allergic asthma and matched controls. Measurements of artery stiffness were calculated by central pulse wave velocity, ultrasonographic strain imaging and ankle-brachial index. Atherosclerotic plaque burden was assessed by colour-coded duplex sonography...
2017: PloS One
https://www.readbyqxmd.com/read/28943272/clinical-outcomes-of-the-upper-urinary-tract-after-ureteral-clipping-for-the-treatment-of-low-or-non-functioning-renal-moieties
#7
Roberto Iglesias Lopes, Nicolas Fernandez, Martin A Koyle, Joana Dos Santos, Jaime Perez, Rodrigo Romao, Armando J Lorenzo
PURPOSE: A growing body of evidence suggest it is safe to ligate the ureter of poorly functioning renal moieties during renal transplantation. Herein, we present clinical outcomes and data on hydronephrosis progression in pediatric cases associated with ectopic ureters and obstructive ureteroceles. MATERIAL AND METHODS: Prospective data collection on 35 consecutive patients (23 female, 12 male) who underwent ureteral clipping between 02/2011 and 08/2016. Patients were divided in four groups [I: duplex system (DS) with ectopic ureter (45...
September 21, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28886989/factors-associated-with-contralateral-deep-venous-thrombosis-after-iliocaval-venous-stenting
#8
S A Khairy, R J Neves, O Hartung, G J O'Sullivan
BACKGROUND: The majority of iliac venous obstructions occur on the left side, and endovascular therapy has become the first line treatment for this condition. A left common iliac venous stent will protrude into the inferior vena cava (IVC) to some extent, thereby covering the contralateral common iliac vein (CIV) outflow. This may increase the risk of thrombosis of the contralateral iliac vein. The aim of this paper was to determine the rate of, and factors associated with, contralateral lower limb venous thrombosis after stenting, and to evaluate the results of salvage revascularisation...
September 5, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28599801/relation-of-ideal-cardiovascular-health-metrics-to-asymptomatic-polyvascular-disease-in-a-chinese-population
#9
MULTICENTER STUDY
Qian Zhang, Ruixuan Jiang, Yizheng Wang, Shufeng Zhang, Shengyun Chen, Yaqing Zhang, Xiuhua Guo, Shouling Wu, Xingquan Zhao
Atherosclerosis is a systemic disease with manifestations in multiple vascular beds. Ideal cardiovascular health (CVH) metrics relate to cardiovascular and cerebrovascular disease. However, the relation between ideal CVH metrics and asymptomatic polyvascular disease (polyVD) is unknown. We collected information on the 7 CVH metrics among 5,224 participants aged ≥40 years from 2010 to 2011. Intracranial artery stenosis, extracranial artery stenosis, and lower extremity artery disease were detected by transcranial Doppler, duplex sonography, and by calculating ankle-brachial index...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28544699/renal-anomalies-and-lymphedema-distichiasis-syndrome-a-rare-association
#10
Gabriela E Jones, Anna K Richmond, Osric Navti, Hatem A Mousa, Stephen Abbs, Edward Thompson, Sahar Mansour, Pradeep C Vasudevan
Lymphedema distichiasis syndrome (LDS) is a rare, autosomal dominant genetic condition, characterized by lower limb lymphedema and distichiasis. Other associated features that have been reported include varicose veins, cleft palate, congenital heart defects, and ptosis. We update a previously reported family with a pathogenic variant in FOXC2 (c.412-413insT) where five affected individuals from the youngest generation had congenital renal anomalies detected on prenatal ultrasound scan. These included four fetuses with hydronephrosis and one with bilateral renal agenesis...
May 23, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28532765/prenatal-complicated-duplex-collecting-system-and-ureterocele-important-risk-factors-for-urinary-tract-infection
#11
Sofia Visuri, Timo Jahnukainen, Seppo Taskinen
PURPOSE: To evaluate the risk of urinary tract infections (UTIs) in infants with prenatally detected complicated duplex collecting system (CDS) or ureterocele. MATERIALS AND METHODS: All patients with prenatally detected CDS (n=34) or single system ureterocele (n=7) who were admitted to our institution between 2003 and 2013 were enrolled in this retrospective analysis. Duplex collecting systems with ureterocele (n=13), vesicoureteral reflux (VUR) (n=20) or nonrefluxing megaureter without ureterocele (n=7) were determined as complicated...
May 11, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28531121/a-qpcr-based-tool-to-diagnose-the-presence-of-harmful-cyanobacteria-and-cyanotoxins-in-drinking-water-sources
#12
Yi-Ting Chiu, Yi-Hsuan Chen, Ting-Shaun Wang, Hung-Kai Yen, Tsair-Fuh Lin
Harmful cyanobacteria have been an important concern for drinking water quality for quite some time, as they may produce cyanotoxins and odorants. Microcystis and Cylindrospermopsis are two common harmful cyanobacterial genera detected in freshwater lakes and reservoirs, with microcystins (MCs) and cylindrospermopsin (CYN) as their important metabolites, respectively. In this study, two sets of duplex qPCR systems were developed, one for quantifying potentially-toxigenic Microcystis and Microcystis, and the other one for cylindrospermopsin-producing cyanobacteria and Cylindrospermopsis...
May 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28440405/copy-number-variation-analysis-in-familial-nonsyndromic-congenital-anomalies-of-the-kidney-and-urinary-tract-evidence-for-the-causative-role-of-a-transposable-element-associated-genomic-rearrangement
#13
Ekaterini Siomou, Artemis G Mitsioni, Vasileios Giapros, Ioanna Bouba, Dimitrios Noutsopoulos, Ioannis Georgiou
Most congenital anomalies of the kidney and urinary tract (CAKUT) are sporadic, but familial occurrence has been described, suggesting a genetic contribution. Copy‑number variations (CNVs) were detected in patients with CAKUT to identify possible novel genomic regions associated with CAKUT. CNVs were investigated in 7 children with CAKUT from three unrelated families using array comparative genomic hybridization: female monozygotic twins with bilateral duplex collecting system/vesicoureteral reflux (VUR)/unilateral renal hypodyspasia (URHD); two male siblings with VUR/URHD; 3 male second cousins, one with bilateral VUR/URHD, one with bilateral VUR and one with ureterovesical junction obstruction (UVJO)...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28411699/outcomes-of-a-single-center-experience-with-classification-and-treatment-of-endothermal-heat-induced-thrombosis-after-endovenous-ablation
#14
Lindsey M Korepta, Jennifer J Watson, M Ashraf Mansour, Christopher M Chambers, Robert F Cuff, Jason D Slaikeu, Peter Y Wong
OBJECTIVE: Endothermal heat-induced thrombosis (EHIT) is a known complication of endothermal venous ablation procedures. EHIT can lead to deep vein thrombosis/pulmonary embolism, which cause significant disability and, rarely, death. Other studies have evaluated risk factors for EHIT. There is an accepted grading system for EHIT, but there is no consensus on treatment type, duration, or follow-up. We retrospectively evaluated all cases of EHIT after radiofrequency ablation or endovenous laser ablation at our institution during a 7-year period, focusing on classification, treatment, and outcomes of EHIT...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28333838/wilms-tumor-extension-into-duplex-ureter-in-a-10-year-old-girl
#15
İbrahim Karnak, Mithat Haliloğlu, Diclehan Orhan, Tezer Kutluk
Ureteral extension of Wilms tumor (WT) is a rare occasion. The association of duplex collecting system and WT is extremely rare. Ureteral extension of WT in a duplex collecting system is an unreported entity to date. A 10-year-old girl presenting with WT extending into upper pole ureter of duplex system is reported to emphasize the importance of preoperative diagnosis to plan step by step surgery in this rare coincidental situation.
April 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28257975/rapid-and-sensitive-detection-of-microrna-via-the-capture-of-fluorescent-dyes-loaded-albumin-nanoparticles-around-functionalized-magnetic-beads
#16
Tianxiang Wei, Dan Du, Zhaoyin Wang, Weiwei Zhang, Yuehe Lin, Zhihui Dai
MicroRNAs (miRNAs) play important roles in gene regulation and cancer development. Nowadays, it is still a challenge to detect low-abundance miRNAs. Here, we present a magnetic fluorescent miRNA sensing system for the rapid and sensitive detection of miRNAs from cell lysates and serum samples. In this system, albumin nanoparticles (Alb NPs) were prepared from inherent biocompatible bovine serum albumin (BSA). A large number of fluorescent dyes were loaded into Alb NPs to make Alb NPs serve as signal molecular nanocarriers for signal amplification...
February 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27920854/recurrent-urinary-tract-infections-in-an-adult-with-a-duplicated-renal-collecting-system
#17
Junaid Raja, Amir M Mohareb, Bilori Bilori
Because of advancements in fetal imaging, anatomic variants of the genitourinary tract are most often discovered in the antenatal period. As such, general internists are less likely to encounter adult patients with previously undiagnosed anatomic abnormalities of the renal collecting system, such as duplicated kidneys. These abnormalities put patients at risk for urinary obstruction and recurrent infections of the urinary tract. We report the case of a 40-year-old diabetic patient with a previously undiagnosed duplex kidney who had recurrent episodes of diabetic ketoacidosis triggered by urinary tract infections...
December 2016: Radiology Case Reports
https://www.readbyqxmd.com/read/27900219/outcome-of-laparoscopic-upper-pole-heminephroureterectomy-in-children-a-two-centre-experience
#18
Ali Serdar Gözen, Haytham Badawy, Dogu Teber, Akram Assem, Jens Rassweiler
OBJECTIVE: To report our multicentre experience and outcomes with laparoscopic transperitoneal and retroperitoneal upper pole heminephroureterectomy (HNU) in children with renal duplex systems and impaired upper pole. PATIENTS AND METHODS: Laparoscopic HNU was performed in 22 children (15 girls, seven boys) with a mean age of 5.9 years. A retroperitoneal approach was used in 17 patients and a transperitoneal approach in the remaining five, between 2005 and 2010...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27852205/generalized-molecular-descriptors-derived-from-event-based-discrete-derivative
#19
Oscar Martínez-Santiago, Reisel Millán Cabrera, Yovani Marrero-Ponce, Stephen J Barigye, Huong Le-Thi-Thu, F Javier Torres, Cesar H Zambrano, Ivan Yaber-Goenaga, Maykel Cruz-Monteagudo, Yoan Martínez López, Facundo Pérez Giménez, Francisco Torrens
In the present study, a generalized approach for molecular structure characterization is introduced, based on the relation frequency matrix (F) representation of the molecular graph and the subsequent calculation of the corresponding discrete derivative (finite difference) over a pair of elements (atoms). In earlier publications (22- 24), an unique event, named connected subgraphs, (based on the Kier-Hall's subgraphs) was systematically employed for the computation of the matrix F. The present report is a generalization of this notion, in which eleven additional events are introduced, classified in three categories, namely, topological (terminal paths, vertex path incidence, quantum subgraphs, walks of length k, Sach's subgraphs), fingerprints (MACCs, E-state and substructure fingerprints) and atomic contributions (Ghose and Crippen atom-types for hydrophobicity and refractivity) for F generation...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27829833/unusual-presentation-of-duplex-kidneys-ureteropelvic-junction-obstruction
#20
Cemile Başdaş, Süleyman Çelebi, Seyithan Özaydın, Birgül Karaaslan, Elmas Reyhan Alim, Ünal Güvenç, Serdar Sander
Aim. Ureteropelvic junction obstruction (UPJO) is rarely associated with a duplex collecting system. We review this unusual anomaly in terms of presentation, diagnostic evaluation, and surgical management. Method. We retrospectively reviewed the medical records of patients diagnosed with a duplex system with UPJO. Result. Sixteen patients (6 girls, 10 boys) with 18 moieties were treated surgically and four patients were treated conservatively. The median age at surgery was two years (range, 2 months to 7 years)...
2016: Advances in Urology
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