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https://www.readbyqxmd.com/read/28726708/potential-of-integrated-vertical-and-horizontal-flow-constructed-wetland-with-native-plants-for-sewage-treatment-under-different-hydraulic-loading-rates
#1
Xuan Cuong Nguyen, Dinh Duc Nguyen, Nguyen Thi Loan, Soon Woong Chang
In this study, a pilot-scale integrated constructed wetland with vertical flow (VF) and horizontal flow (HF) in series was designed and investigated to evaluate sewage wastewater treatment capacity. The VF unit was planted with Canna indica and was 1.2 m long, 1.2 m wide, and 1.2 m high; whereas the HF unit contained Colocasia esculenta and was 3.0 m long, 1.0 m wide, and 1.0 m high. The system was operated under different hydraulic loading rates (HLRs) of 0.1, 0.2, and 0.15 m/d. The effluent concentrations differed as HLR changed, and the means were total suspended solids (TSS): 87 mg/L; biological oxygen demand (BOD5): 31 mg/L; chemical oxygen demand (CODCr): 59 mg/L; ammonium nitrogen (NH4-N): 5...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28726670/solid-state-nanopore-based-biomimetic-voltage-gated-ion-channels
#2
Matthew Pevarnik, Weibin Cui, Sukru Yemenicioglu, Justin Rofeh, Luke Theogarajan
Voltage gating is essential to the computational ability of neurons. We show this effect can be mimicked in a solid-state nanopore by functionalizing the pore interior with a redox active molecule. We study the integration of an active biological molecule, a quinone, into a solid state nanopore and its subsequent induced voltage gating. We show that the voltage gating effect mimics biological gating systems in its classic sigmoidal voltage response, unlike previous synthetic voltage gating systems. Initially the quinone undergoes a reduction due to radicals in the bulk solution and is converted to the hydroquinone state...
July 20, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28726349/aspherical-nanostructured-microparticles-for-targeted-gene-delivery-to-alveolar-macrophages
#3
Michael Möhwald, Shashank Reddy Pinnapireddy, Bodo Wonnenberg, Marcel Pourasghar, Marijas Jurisic, Andrea Jung, Claudia Fink-Straube, Thomas Tschernig, Udo Bakowsky, Marc Schneider
Introducing novel shapes to particulate carrier systems adds unique features to modern drug and gene delivery. Depending on the route of administration, particle geometry can influence deposition and fate within biological environments. In this work, a template-assisted engineering technique is applied, providing full control of size and shape in the preparation of aspherical, nanostructured microparticles. Based on the interconnection of nanoparticles, stabilized by a functional layer-by-layer (LbL) coating, the resulting cylindrical micrometer architecture is especially qualified for pulmonary delivery...
July 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28725897/integration-and-application-of-optical-chemical-sensors-in-microbioreactors
#4
Pia Gruber, Marco P C Marques, Nicolas Szita, Torsten Mayr
The quantification of key variables such as oxygen, pH, carbon dioxide, glucose, and temperature provides essential information for biological and biotechnological applications and their development. Microfluidic devices offer an opportunity to accelerate research and development in these areas due to their small scale, and the fine control over the microenvironment, provided that these key variables can be measured. Optical sensors are well-suited for this task. They offer non-invasive and non-destructive monitoring of the mentioned variables, and the establishment of time-course profiles without the need for sampling from the microfluidic devices...
July 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28725530/smart-fluid-systems-the-advent-of-autonomous-liquid-robotics
#5
REVIEW
A Chiolerio, Marco B Quadrelli
Organic, inorganic or hybrid devices in the liquid state, kept in a fixed volume by surface tension or by a confining membrane that protects them from a harsh environment, could be used as biologically inspired autonomous robotic systems with unique capabilities. They could change shape according to a specific exogenous command or by means of a fully integrated adaptive system, and provide an innovative solution for many future applications, such as space exploration in extreme or otherwise challenging environments, post-disaster search and rescue in ground applications, compliant wearable devices, and even in the medical field for in vivo applications...
July 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28724354/novel-plasmodium-falciparum-metabolic-network-reconstruction-identifies-shifts-associated-with-clinical-antimalarial-resistance
#6
Maureen A Carey, Jason A Papin, Jennifer L Guler
BACKGROUND: Malaria remains a major public health burden and resistance has emerged to every antimalarial on the market, including the frontline drug, artemisinin. Our limited understanding of Plasmodium biology hinders the elucidation of resistance mechanisms. In this regard, systems biology approaches can facilitate the integration of existing experimental knowledge and further understanding of these mechanisms. RESULTS: Here, we developed a novel genome-scale metabolic network reconstruction, iPfal17, of the asexual blood-stage P...
July 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28724201/variations-in-the-bioactive-compounds-composition-and-biological-activities-of-loofah-luffa-cylindrica-fruits-in-relation-to-maturation-stages
#7
Takoua Ben Hlel, Feten Belhadj, Fatih Gül, Muhammed Altun, Ayşe ŞahinYağlıoğlu, Ibrahim Demirtaş, M Nejib Marzouki
The present work aimed to determine the antioxidant and antiproliferative potential of Luffa cylindrica fruits collected at two different maturation stages and to identify and compare their functional components composition. The methanolic extracts of L. cylindrica fruits harvested at 60 to 65 days after seeding (S1) and 85 to 90 days after seeding (S2) were investigated for their antioxidant activity using various assays. Furthermore, the antiproliferative activity of the extracts against HeLa human cervical cancer cells was explored with xCELLigence real time cell analyzer while the effect of the samples on the membrane integrity of the same cell line was assessed using LDH cytotoxicity leakage assay...
July 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28721608/a-new-light-trap-model-as-an-alternative-for-controlling-pests-in-eucalyptus-plantations
#8
R G Mafia, E B Loureiro, J B Silva, J A C Simões, T G Zarpelon, N S Bezerra Junior, M B Damacena
Eucalyptus plantations can be affected by species of defoliating caterpillars. The integrated management of this group primarily involves a monitoring system, natural enemies, and biological products. Alternative control methods, including the use of conventional light traps, have not been adopted, mostly because of their low efficiency. Therefore, a more efficient light trap model was developed. The new model allowed the capture of 3.6 times as many insects as the conventional model, with a 261% gain in control efficiency...
July 18, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28721422/towards-on-site-analysis-of-complex-matrices-by-solid-phase-microextraction-transmission-mode-coupled-to-a-portable-mass-spectrometer-via-direct-analysis-in-real-time
#9
Germán Augusto Gómez-Ríos, Tijana Vasiljevic, Emanuela Gionfriddo, Miao Yu, Janusz Pawliszyn
On-site screening for target analytes in complex matrices, such as biofluids and food specimens, not only requires reliable and portable analytical instrumentation, but also solvent-free and easy-to-use sampling/sample preparation approaches that allow analytes of interest to be isolated from such matrices. The integration of sampling devices with field deployable instruments should be as efficient as possible, and should aim to provide rapid, precise, and accurate results that enable quick on-site decision...
July 19, 2017: Analyst
https://www.readbyqxmd.com/read/28720757/integrative-analyses-of-translatome-and-transcriptome-reveal-important-translational-controls-in-brown-and-white-adipose-regulated-by-micrornas
#10
David W Reid, Dan Xu, Peng Chen, Hongyuan Yang, Lei Sun
The epidemic of obesity and diabetes has markedly spurred the research interest in adipocyte biology. Brown adipocytes are specialized for energy expenditure and of therapeutic interest for treatment of metabolic diseases, but how brown adipocytes are distinguished from white adipocytes at the level of translational regulation remains poorly understood. To systemically determine the translational control of gene expression in adipose tissue, we performed ribosome profiling and RNA-seq in parallel to depict the translatome and transcriptome changes during primary brown and white adipogenesis, and between brown and white adipose tissue...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720508/to-swim-or-not-to-swim-a-population-level-model-of-xenopus-tadpole-decision-making-and-locomotor-behaviour
#11
Roman Borisyuk, Robert Merrison-Hort, Steve R Soffe, Stella Koutsikou, Wen-Chang Li
We present a detailed computational model of interacting neuronal populations that mimic the hatchling Xenopus tadpole nervous system. The model includes four sensory pathways, integrators of sensory information, and a central pattern generator (CPG) network. Sensory pathways of different modalities receive inputs from an "environment"; these inputs are then processed and integrated to select the most appropriate locomotor action. The CPG populations execute the selected action, generating output in motor neuron populations...
July 15, 2017: Bio Systems
https://www.readbyqxmd.com/read/28719406/toward-a-biopsychosocial-ecology-of-the-human-microbiome-brain-gut-axis-and-health
#12
Karl J Maier, Mustafa al'Absi
OBJECTIVE: Rapidly expanding insights to the human microbiome and health suggest that Western medicine is poised for significant evolution, or perhaps revolution - this while the field continues on a trajectory from reductionism to a biopsychosocial (BPS) paradigm recognizing biological, psychological, and social influences on health. The apparent sensitivity of the microbiota to perturbations across BPS domains suggests that a broad and inclusive framework is needed to develop applicable knowledge in this area...
July 18, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28719102/plant-viral-and-bacteriophage-delivery-of-nucleic-acid-therapeutics
#13
REVIEW
Patricia Lam, Nicole F Steinmetz
Nucleic acid therapeutics have emerged as a powerful method for treatment of many diseases. However, the challenge lies in safe and efficient delivery of nucleic acids to their target site, as they need to cross various extracellular and intracellular barriers. Mammalian viruses have initially been favored for delivery of nucleic acid therapeutics, but safety concerns regarding their immunogenicity and potential of integration have fueled the search for alternative delivery strategies. For example, chemistry and bioengineering have led to advances in the use of nonviral vectors composed of lipids and other polymers; nevertheless, the synthetic systems often do not match the efficiency achieved using the biological systems...
July 18, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28718930/genesis-1-1-a-hybrid-parallel-molecular-dynamics-simulator-with-enhanced-sampling-algorithms-on-multiple-computational-platforms
#14
Chigusa Kobayashi, Jaewoon Jung, Yasuhiro Matsunaga, Takaharu Mori, Tadashi Ando, Koichi Tamura, Motoshi Kamiya, Yuji Sugita
GENeralized-Ensemble SImulation System (GENESIS) is a software package for molecular dynamics (MD) simulation of biological systems. It is designed to extend limitations in system size and accessible time scale by adopting highly parallelized schemes and enhanced conformational sampling algorithms. In this new version, GENESIS 1.1, new functions and advanced algorithms have been added. The all-atom and coarse-grained potential energy functions used in AMBER and GROMACS packages now become available in addition to CHARMM energy functions...
July 18, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28716510/evaluation-of-in-vivo-and-in-vitro-models-of-toxicity-by-comparison-of-toxicogenomics-data-with-the-literature
#15
Katerina Taškova, Jean-Fred Fontaine, Ralf Mrowka, Miguel A Andrade-Navarro
Toxicity affecting humans is studied by observing the effects of chemical substances in animal organisms (in vivo) or in animal and human cultivated cell lines (in vitro). Toxicogenomics studies collect gene expression profiles and histopathology assessment data for hundreds of drugs and pollutants in standardized experimental designs using different model systems. These data are an invaluable source for analyzing genome-wide drug response in biological systems. However, a problem remains that is how to evaluate the suitability of heterogeneous in vitro and in vivo systems to model the many different aspects of human toxicity...
July 14, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28716035/systematic-evaluation-of-characteristics-of-the-membrane-based-fed-batch-shake-flask
#16
P Philip, K Meier, D Kern, J Goldmanns, F Stockmeier, C Bähr, J Büchs
BACKGROUND: The initial part of process development involves extensive screening programs to identify optimal biological systems and cultivation conditions. For a successful scale-up, the operation mode on screening and production scale must be as close as possible. To enable screening under fed-batch conditions, the membrane-based fed-batch shake flask was developed. It is a shake flask mounted with a central feed reservoir with an integrated rotating membrane tip for a controlled substrate release...
July 17, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28716030/modeling-de-novo-granulation-of-anaerobic-sludge
#17
Anna Doloman, Honey Varghese, Charles D Miller, Nicholas S Flann
BACKGROUND: A unique combination of mechanical, physiochemical and biological forces influences granulation during processes of anaerobic digestion. Understanding this process requires a systems biology approach due to the need to consider not just single-cell metabolic processes, but also the multicellular organization and development of the granule. RESULTS: In this computational experiment, we address the role that physiochemical and biological processes play in granulation and provide a literature-validated working model of anaerobic granule de novo formation...
July 17, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28714506/an-integrated-microwell-array-platform-for-cell-lasing-analysis
#18
Qiushu Chen, Yu-Cheng Chen, Zhizheng Zhang, Biming Wu, Rhima Coleman, Xudong Fan
Biological cell lasers are emerging as a novel technology in biological studies and biomedical engineering. The heterogeneity of cells, however, can result in various lasing behaviors from cell to cell. Thus, the capability to track individual cells during laser investigation is highly desired. In this work, a microwell array was integrated with high-quality Fabry-Pérot cavities for addressable and automated cell laser studies. Cells were captured in the microwells and the corresponding cell lasing was achieved and analyzed using SYTO9-stained Sf9 cells as a model system...
July 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28714074/altered-metabolomic-genomic-signature-a-potential-noninvasive-biomarker-of-epilepsy
#19
Helen C Wu, Fabien Dachet, Farhad Ghoddoussi, Shruti Bagla, Darren Fuerst, Jeffrey A Stanley, Matthew P Galloway, Jeffrey A Loeb
OBJECTIVE: This study aimed to identify noninvasive biomarkers of human epilepsy that can reliably detect and localize epileptic brain regions. Having noninvasive biomarkers would greatly enhance patient diagnosis, patient monitoring, and novel therapy development. At the present time, only surgically invasive, direct brain recordings are capable of detecting these regions with precision, which severely limits the pace and scope of both clinical management and research progress in epilepsy...
July 17, 2017: Epilepsia
https://www.readbyqxmd.com/read/28713771/integrating-hyperthermia-into-modern-radiation-oncology-what-evidence-is-necessary
#20
REVIEW
Jan C Peeken, Peter Vaupel, Stephanie E Combs
Hyperthermia (HT) is one of the hot topics that have been discussed over decades. However, it never made its way into primetime. The basic biological rationale of heat to enhance the effect of radiation, chemotherapeutic agents, and immunotherapy is evident. Preclinical work has confirmed this effect. HT may trigger changes in perfusion and oxygenation as well as inhibition of DNA repair mechanisms. Moreover, there is evidence for immune stimulation and the induction of systemic immune responses. Despite the increasing number of solid clinical studies, only few centers have included this adjuvant treatment into their repertoire...
2017: Frontiers in Oncology
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