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https://www.readbyqxmd.com/read/29332020/predictors-of-improvements-in-mental-health-from-mindfulness-meditation-in-stressed-older-adults
#1
Barry S Oken, Elena Goodrich, Daniel Klee, Tabatha Memmott, Jeffrey Proulx
Context • The benefits of a mindfulness meditation (MM) intervention are most often evidenced by improvements in self-rated stress and mental health. Given the physiological complexity of the psychological stress system, it is likely that some people benefit significantly, whereas others do not. Clinicians and researchers could benefit from further exploration to determine which baseline factors can predict clinically significant improvements from MM. Objectives • The study intended to determine (1) whether the baseline measures for participants who significantly benefitted from MM training were different from the baseline measures of participants who did not, and (2) whether a classification analysis using a decision-tree, machine-learning approach could be useful in predicting which individuals would be most likely to improve...
January 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29326030/patient-reported-outcomes-following-abiraterone-acetate-plus-prednisone-added-to-androgen-deprivation-therapy-in-patients-with-newly-diagnosed-metastatic-castration-naive-prostate-cancer-latitude-an-international-randomised-phase-3-trial
#2
Kim N Chi, Andrew Protheroe, Alfredo Rodríguez-Antolín, Gaetano Facchini, Henrik Suttman, Nobuaki Matsubara, Zhangqun Ye, Bhumsuk Keam, Ronaldo Damião, Tracy Li, Kelly McQuarrie, Bin Jia, Peter De Porre, Jason Martin, Mary B Todd, Karim Fizazi
BACKGROUND: In the LATITUDE trial, addition of abiraterone acetate plus prednisone to androgen deprivation therapy (ADT) improved overall survival compared with placebos plus ADT in patients with newly diagnosed, high-risk, metastatic castration-naive prostate cancer. Understanding the effects of treatments on patient-reported outcomes (PROs) and health-related quality of life (HRQOL) is important for treatment decisions; therefore we aimed to analyse the effects of ADT plus abiraterone acetate and prednisone versus ADT plus placebos on PROs and HRQOL in patients in the LATITUDE study...
January 8, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29324264/driver-education-enhancing-knowledge-of-sleep-fatigue-and-risky-behaviour-to-improve-decision-making-in-young-drivers
#3
Pasquale K Alvaro, Nicole M Burnett, Gerard A Kennedy, William Yu Xun Min, Marcus McMahon, Maree Barnes, Melinda Jackson, Mark E Howard
This study assessed the impact of an education program on knowledge of sleepiness and driving behaviour in young adult drivers and their performance and behaviour during simulated night driving. Thirty-four participants (18-26 years old) were randomized to receive either a four-week education program about sleep and driving or a control condition. A series of questionnaires were administered to assess knowledge of factors affecting sleep and driving before and after the four-week education program. Participants also completed a two hour driving simulator task at 1am after 17 h of extended wakefulness to assess the impact on driving behaviour...
January 8, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29324069/evidence-based-guidelines-for-fatigue-risk-management-in-emergency-medical-services
#4
P Daniel Patterson, J Stephen Higgins, Hans P A Van Dongen, Daniel J Buysse, Ronald W Thackery, Douglas F Kupas, David S Becker, Bradley E Dean, George H Lindbeck, Francis X Guyette, Josef H Penner, John M Violanti, Eddy S Lang, Christian Martin-Gill
BACKGROUND: Administrators of Emergency Medical Services (EMS) operations lack guidance on how to mitigate workplace fatigue, which affects greater than half of all EMS personnel. The primary objective of the Fatigue in EMS Project was to create an evidence-based guideline for fatigue risk management tailored to EMS operations. METHODS: Systematic searches were conducted from 1980 to September 2016 and guided by seven research questions framed in the Population, Intervention, Comparison, Outcome (PICO) framework...
January 11, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29322372/examination-of-patient-reported-outcomes-in-association-with-tnf-inhibitor-treatment-response-results-from-a-us-observational-cohort-study
#5
Cynthia J Larmore, Natalie N Boytsov, Carol L Gaich, Xiang Zhang, Andre B Araujo, Sabrina Rebello, Bob A Salim, George W Reed, Leslie R Harrold
INTRODUCTION: Implementation of a treat-to-target strategy is challenging when the patient and physician prioritize different goals. This study aimed to "translate" improvements in Clinical Disease Activity Index (CDAI) to concepts that resonate with patients (such as pain, fatigue, morning stiffness) by examining the association between changes in disease activity and patient-reported outcomes (PROs) in a national cohort of patients with rheumatoid arthritis (RA) initiating their first biologic treatment...
January 10, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29320460/fatigue-reliability-assessment-for-orthotropic-steel-decks-based-on-long-term-strain-monitoring
#6
Yang Deng, Aiqun Li, Dongming Feng
A time-dependent fatigue reliability assessment approach is proposed for welded details of orthotropic steel decks (OSDs) using long-term strain monitoring data. The fatigue reliability limit function of the welded details is established based on the Eurocode specifications. Depending on the distribution characteristics of the measured daily equivalent stress range, either the lognormal distribution or Gaussian mixture model (GMM) is selected to quantify its uncertainty. Subsequently, the fatigue reliability can be calculated using either an explicit formula or the Monte Carlo method...
January 10, 2018: Sensors
https://www.readbyqxmd.com/read/29287742/investigating-real-time-monitoring-of-fatigue-indicators-of-new-zealand-forestry-workers
#7
Judy Bowen, Annika Hinze, Christopher Griffiths
The New Zealand forestry industry has one of the highest fatality and injury rates of any industrial sector in the country. Worker fatigue has been identified as one of the main contributing factors. Currently no independent and objective large data source is available that might support an analysis of this, or provide the basis for ongoing monitoring to further investigate. In order to successfully manage fatigue in the forestry workplace, we must identify suitable ways of detecting it. Industry partners are increasingly looking at monitoring solutions (particularly lightweight, wearable technology) that aim to measure worker activities and physiological metrics in order to determine if they are fatigued...
December 27, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29282261/abc-index-quantifying-experienced-burden-of-copd-in-a-discrete-choice-experiment-and-predicting-costs
#8
Lucas Ma Goossens, Maureen Pmh Rutten-van Mölken, Melinde Rs Boland, Bas Donkers, Marcel F Jonker, Annerika Hm Slok, Philippe L Salomé, Onno Cp van Schayck, Johannes Ccm In 't Veen, Elly A Stolk
OBJECTIVE: The Assessment of Burden of COPD (ABC) tool supports shared decision making between patient and caregiver. It includes a coloured balloon diagram to visualise patients' scores on burden indicators. We aim to determine the importance of each indicator from a patient perspective, in order to calculate a weighted index score and investigate whether that score is predictive of costs. DESIGN: Discrete choice experiment. SETTING AND PARTICIPANTS: Primary care and secondary care in the Netherlands...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29248102/the-center-for-vein-restoration-study-on-presenting-symptoms-treatment-modalities-and-outcomes-in-medicare-eligible-patients-with-chronic-venous-disorders
#9
Peter J Pappas, Sanjiv Lakhanpal, Khanh Q Nguyen, Rohan Vanjara
BACKGROUND: Chronic venous disorders (CVDs) have been estimated to affect up to 20 million Americans. Despite this huge prevalence, the signs, symptoms, and treatment outcomes in patients 65 years of age and older are not well defined. Our goal was to determine the presentation and treatment outcomes in elderly patients compared with a cohort of patients younger than 65 years. METHODS: From January 2015 to December 2016, we retrospectively reviewed prospectively collected data from 38,750 patients with CVD from the Center for Vein Restoration's electronic medical record (NextGen Healthcare Information Systems, Irvine, Calif)...
January 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29238196/the-role-of-new-antidepressants-in-clinical-practice-in-canada-a-brief-review-of-vortioxetine-levomilnacipran-er-and-vilazodone
#10
REVIEW
Roger S McIntyre
Although many branded and generic antidepressants are approved for the treatment of major depressive disorder (MDD) in Canada, efficacy and tolerability differ among patients, and new treatment options are needed. Symptom types (eg, fatigue, energy/motivation, cognition, and functioning), medication type, treatment duration, and the need for maintenance therapy are factors that may influence treatment effectiveness. Three antidepressants, vortioxetine, levomilnacipran extended-release (ER), and vilazodone have recently become available in Canada...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29237488/clinical-reminder-alert-fatigue-in-healthcare-a-systematic-literature-review-protocol-using-qualitative-evidence
#11
Ruth Backman, Susan Bayliss, David Moore, Ian Litchfield
BACKGROUND: Integrated reminders within clinical systems have become more prevalent due to the use of electronic health records and evidence demonstrating an increase in compliance within practice. Clinical reminders are assessed for effectiveness on an individual basis, rather than in combination with existing prompts for other conditions. The growing number of prompts may be counter-productive as healthcare professionals are increasingly suffering from "reminder fatigue" meaning many reminders are ignored...
December 13, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29233414/teaching-drug-utilization-review-skills-via-a-simulated-clinical-decision-making-exercise
#12
Cortney M Mospan, Katelyn M Alexander
BACKGROUND: Drug utilization review (DUR) is a central role of the pharmacist, especially within the community pharmacy setting. Previous literature has shown risk of "alert fatigue", supporting the necessity of pharmacists to utilize a step-wise approach in evaluation of drug therapy during the verification process. Many students are intimidated by this process, and may lack verification practice or experience until their first day as a licensed pharmacist. EDUCATIONAL ACTIVITY AND SETTING: An innovative skills-based laboratory exercise was developed for third-year pharmacy students to develop DUR skills...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29227388/12-hour-shifts-literature-reviewed-wise-use-challenged
#13
Betty Kupperschmidt
Concern is reported about the negative outcomes of 12-hour shifts for nurses, including sleep-deprived fatigue, negative neurobehavioral outcomes, and patient safety. However, 12-hour shifts remain the prevailing staffing method. When should the concern for nurses' health and well-being be factored into staffing decisions? If the 12-hour model was used more wisely, that is, nurses were not working too much and/or too long, would there be a need for change? Will nurses and researchers pursue ways to address the negative outcomes of 12-hour shifts?...
January 2018: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
https://www.readbyqxmd.com/read/29200118/palliative-care-end-of-life-care-and-advance-care-planning-in-neuro-oncology
#14
Tobias Walbert
PURPOSE OF REVIEW: Despite new therapeutic approaches, most patients with high-grade glioma face limited overall survival and have a high symptom burden throughout their disease trajectory, especially in the end-of-life phase. This article provides an overview of the role of palliative care in neuro-oncology. Management recommendations are made for neurologic symptoms in patients with advanced brain tumors, including headaches, nausea, and fatigue. Special attention is given to how and when to involve subspecialty palliative care and hospice services to improve symptom management during active tumor treatment and in the end-of-life phase of patients with brain tumors...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29195711/better-specification-of-triggers-to-reduce-the-number-of-drug-interaction-alerts-in-primary-care
#15
Mette Heringa, Annet van der Heide, Annemieke Floor-Schreudering, Peter A G M De Smet, Marcel L Bouvy
OBJECTIVE: Drug interaction alerts (drug-drug and drug-disease interaction alerts) for chronic medications substantially contribute to alert fatigue in primary care. The aim of this study was to determine which events require (re)assessment of a drug interaction and whether using these events as triggers in clinical decision support systems (CDSSs) would affect the alert rate. METHODS: Two random 5% data samples from the CDSSs of 123 community pharmacies were used: dataset 1 and 2...
January 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29186628/the-complex-holiday-calendar-of-1902-responses-to-the-coronation-of-edward-vii-and-the-growth-of-edwardian-event-fatigue
#16
Ben Roberts
The coronation of Edward VII and events to mark the end of the South African War led to a series of public ceremonies and events in the United Kingdom that had a profound effect on attitudes linked to national occasions and public holidays. This article explores the circumstances surrounding the numerous local and national holidays of 1902. It considers the decision-making process linked to the declaration of a coronation double-bank holiday, which demonstrated the inadequacy of contemporary legislation. The public response to the postponement of the coronation, due to the king's contraction of appendicitis, led to a period of 'event fatigue' in response to further ceremonial events...
December 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/29167485/sleep-deprivation-diminishes-attentional-control-effectiveness-and-impairs-flexible-adaptation-to-changing-conditions
#17
Paul Whitney, John M Hinson, Brieann C Satterfield, Devon A Grant, Kimberly A Honn, Hans P A Van Dongen
Insufficient sleep is a global public health problem resulting in catastrophic accidents, increased mortality, and hundreds of billions of dollars in lost productivity. Yet the effect of sleep deprivation (SD) on decision making and performance is often underestimated by fatigued individuals and is only beginning to be understood by scientists. The deleterious impact of SD is frequently attributed to lapses in vigilant attention, but this account fails to explain many SD-related problems, such as loss of situational awareness and perseveration...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29165609/effects-of-cognitive-loading-and-force-on-upper-trapezius-fatigue
#18
C Deeney, L W O'Sullivan
Background: Musculoskeletal disorders (MSDs) are particularly common in the shoulder/neck region for some tasks that involve low force exertions, for example computer work. It has been demonstrated that muscle activity may be stimulated by cognitively demanding tasks. There is a lack of studies on the relationship between qualitative levels of cognitive loading, level of muscle activity, and muscle fatigue. Aims: To investigate the effects of quantitative levels of cognitive loading on conduction velocity changes and isometric endurance times for the upper trapezius...
November 19, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29159738/prospective-assessment-of-first-year-quality-of-life-after-pelvic-exenteration-for-gynecologic-malignancy-a-french-multicentric-study
#19
A Martinez, T Filleron, P Rouanet, P Méeus, E Lambaudie, J M Classe, F Foucher, F Narducci, S Gouy, F Guyon, F Marchal, E Jouve, P E Colombo, A Mourregot, M Rivoire, N Chopin, G Houvenaeghel, I Jaffre, J Leveque, V Lavoue, E Leblanc, P Morice, E Stoeckle, J L Verheaghe, D Querleu, G Ferron
BACKGROUND: Pelvic exenteration remains one of the most mutilating procedures, with important postoperative morbidity, an altered body image, and long-term physical and psychosocial concerns. This study aimed to assess quality of life (QOL) during the first year after pelvic exenteration for gynecologic malignancy performed with curative intent. METHODS: A French multicentric prospective study was performed by including patients who underwent pelvic exenteration...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29155338/financial-toxicity-in-bladder-cancer-patients-reasons-for-delay-in-care-and-effect-on-quality-of-life
#20
Marianne M Casilla-Lennon, Seul Ki Choi, Allison M Deal, Jeannette T Bensen, Gopal Narang, Pauline Filippou, Benjamin McCormick, Raj Pruthi, Eric Wallen, Hung-Jui Tan, Michael Woods, Matthew Nielsen, Angela Smith
PURPOSE: Costly surveillance and treatment of bladder cancer can lead to financial toxicity (FT), a treatment-related financial burden. Our objective was to define the prevalence of FT among bladder cancer patients and identify delays in care and its effect on health-related quality of life (HRQOL). METHODS: We identified bladder cancer patients in the UNC Health Registry/Cancer Survivorship Cohort. FT was defined as agreement with having "to pay more for medical care than you can afford...
November 16, 2017: Journal of Urology
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