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https://www.readbyqxmd.com/read/28822763/activating-transcription-factor-3-regulates-chemokine-expression-in-contracting-c2c12-myotubes-and-in-mouse-skeletal-muscle-after-eccentric-exercise
#1
R Fernández-Verdejo, A M Vanwynsberghe, T Hai, L Deldicque, M Francaux
Activating transcription factor (ATF) 3 regulates chemokine expression in various cell types and tissues. Herein, we studied this regulation in contracting muscle cells in vitro, and in skeletal muscle after muscle-damaging exercise in vivo. C2C12 myotubes with normal or low ATF3 levels (atf3_siRNA) were electrically stimulated (EPS). Also, ATF3-knockout (ATF3-KO) and control mice ran downhill until exhaustion, and muscles were analyzed post-exercise. EPS increased ATF3 levels in myotubes (P < 0.01)...
August 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28822657/a-systematic-review-of-muscle-morphology-and-function-in-intermittent-claudication
#2
REVIEW
Amy E Harwood, Stephanie King, Joshua Totty, George E Smith, Natalie Vanicek, Ian C Chetter
OBJECTIVE: Intermittent claudication (IC) is frequently associated with deterioration in walking capacity and physical function, and it can often result in an impairment in balance. Whereas supervised exercise is recommended by the National Institute for Health and Care Excellence as the first-line treatment, the mechanism behind walking improvement is poorly understood. The existing literature suggests that there may be some physiologic change to the skeletal muscle contributing to the functional impairment, but these data are conflicting...
August 16, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28821950/the-effects-of-supramaximal-versus-submaximal-intensity-eccentric-training-when-performed-until-volitional-fatigue
#3
Joel R Krentz, Philip D Chilibeck, Jonathan P Farthing
PURPOSE: Our purpose was to compare supramaximal versus submaximal intensity eccentric training performed until volitional fatigue. METHODS: Thirty-two young adults (19 males) were randomized into one of three groups: (1) ECC110 performed eccentric (ECC) only contractions at 110% of concentric (CON) 1-repetition maximum (1RM); (2) ECC80 performed ECC only contractions at 80% of CON 1RM; (3) a control group. Training progressed from 3 to 6 sets of unilateral ECC training of the elbow flexors over 8 weeks, with each set performed until volitional fatigue...
August 18, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28820857/kinematic-and-neuromuscular-measures-of-intensity-during-plyometric-jumps
#4
David Cristóbal Andrade, Oscar Manzo, Ana Rosa Beltrán, Cristian Álvarez, Rodrigo Del Rio, Camilo Toledo, Jason Moran, Rodrigo Ramirez-Campillo
The aim of this study was to assess jumping performance and neuromuscular activity in lower limb muscles after drop jumps (DJ) from different drop heights (intensity) and during continuous jumping (fatigue), using markers such as reactive strength, jump height, mechanical power and surface electromyography (sEMG). The eccentric (EC) and concentric (CON) sEMG from the medial gastrocnemius (MG), biceps femoris (BF) and rectus (R) muscles were assessed during all tests. In a cross-sectional, randomized study, eleven volleyball players (age 24...
August 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28819595/early-intraprosthetic-dislocation-of-a-dual-mobility-acetabular-construct-after-total-hip-arthroplasty
#5
Vineet Tyagi, Oluwaseun Akinbo
INTRODUCTION: The concept of a dual mobility (DM) cup has been in existence for more than 40 years and was initially popularized in Europe. Only recently has it started to garner attention in the United States. Its design, consisting of a small femoral head articulating within a larger polyethylene (PE) insert, which articulates with an outer shell, has found increasing use in patients that are at risk for post-operative dislocations. This case report describes a case of recurrent total hip arthroplasty (THA) dislocation managed with the implantation of a DM cup with an acute intraprosthetic dislocation of the DM construct...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28817413/actn3-r577x-polymorphism-is-associated-with-the-incidence-and-severity-of-injuries-in-professional-football-players
#6
Massidda Myosotis, Voisin Sarah, Culigioni Claudia, Piras Francesco, Cugia Paolo, Yan Xu, Eynon Nir, Carla M Calò
OBJECTIVE: The ACTN3 R577X gene variant results in the absence of the α-actinin-3 protein in ∼18% of humans worldwide and has been associated with athletic performance and increased susceptibility to eccentric muscle damage. The aim of this study was to investigate the association between ACTN3 R577X variant and indirect muscle disorders/injuries in professional football players. DESIGN: A case-control, genotype-phenotype association study. INTERVENTION: Two hundred fifty-seven male professional Italian football players (from Serie A, Primavera, Allievi, and Giovanissimi; age = 21...
August 16, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28810996/rhabdomyolysis-after-crawling-military-training
#7
Danit Atias-Varon, Haggai Sherman, Ran Yanovich, Yuval Heled
INTRODUCTION: Rhabdomyolysis is a syndrome characterized by muscle necrosis followed by release of intracellular muscle contents into the circulation. Exertional rhabdomyolysis (ER) occurs in response to nonfamiliar and/or excessive, prolonged, or repetitive exercises, with eccentric characteristics. In military populations, due to the type of intense, all out physical loads, ER is a significant threat, particularly when training under heat stress. However, many other etiologies exist, and clinical presentations vary greatly...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28806100/including-the-copenhagen-adduction-exercise-in-the-fifa-11-provides-missing-eccentric-hip-adduction-strength-effect-in-male-soccer-players-a-randomized-controlled-trial
#8
Joar Harøy, Kristian Thorborg, Andreas Serner, André Bjørkheim, Linn E Rolstad, Per Hölmich, Roald Bahr, Thor Einar Andersen
BACKGROUND: The FIFA 11+ was developed as a complete warm-up program to prevent injuries in soccer players. Although reduced hip adduction strength is associated with groin injuries, none of the exercises included in the FIFA 11+ seem to specifically target hip adduction strength. PURPOSE: To investigate the effect on eccentric hip adduction strength of the FIFA 11+ warm-up program with or without the Copenhagen adduction exercise. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28805986/histiocytic-sarcoma-new-insights-into-fna-cytomorphology-and-molecular-characteristics
#9
Yin P Hung, Scott B Lovitch, Xiaohua Qian
BACKGROUND: Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphologic and immunophenotypic features of histiocytes. Molecular characteristics of HS and fine-needle aspiration (FNA) criteria for its diagnosis have not been established. METHODS: A case series of HS in 8 FNA samples from 6 patients was reviewed along with histopathologic and clinical data. Immunohistochemistry was performed on cell blocks (3 cases), core biopsies (5 cases), and surgical specimens (4 cases)...
August 2017: Cancer
https://www.readbyqxmd.com/read/28799637/facilitating-the-analysis-of-the-multifocal-electroretinogram-using-the-free-software-environment-r
#10
Richard Bergholz, Mirjam Rossel, Ralf M Dutescu, Klaas P Vöge, Daniel J Salchow
PURPOSE: The large amount of data rendered by the multifocal electroretinogram (mfERG) can be analyzed and visualized in various ways. The evaluation and comparison of more than one examination is time-consuming and prone to create errors. Using the free software environment R we developed a solution to average the data of multiple examinations and to allow a comparison of different patient groups. METHODS: Data of single mfERG recordings as exported in .csv format from a RETIport 21 system (version 7/03, Roland Consult) or manually compiled ...
August 7, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28799160/intramuscular-perfusion-response-in-delayed-onset-muscle-soreness-doms-a-quantitative-analysis-with-contrast-enhanced-ultrasound-ceus
#11
Marion Kellermann, Rafael Heiss, Bernd Swoboda, Kolja Gelse, Jürgen Freiwald, Casper Grim, Armin Nagel, Michael Uder, Dane Wildner, Thilo Hotfiel
The purpose of this study was to analyse intramuscular perfusion response in ultrastructural muscle lesions, by applying contrast-enhanced ultrasound (CEUS) to a delayed onset muscle soreness (DOMS) model. Results of this analysis were compared to high-resolution 3 Tesla MRI T2-weighted sequences. 14 healthy participants were recruited. Average perfusion parameters, represented as Peak enhancement (contrast agent inflow) and wash-in area under curve (WiAUC) of the gastrocnemius (GM) and soleus muscle (SM) were assessed before (baseline) and 60 h after inducing DOMS by eccentric exercise...
August 10, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28797108/natural-disease-history-of-mouse-models-for-limb-girdle-muscular-dystrophy-types-2d-and-2f
#12
S Pasteuning-Vuhman, K Putker, C L Tanganyika-de Winter, J W Boertje-van der Meulen, L van Vliet, M Overzier, J J Plomp, A Aartsma-Rus, M van Putten
Limb-girdle muscular dystrophy types 2D and 2F (LGMD 2D and 2F) are autosomal recessive disorders caused by mutations in the alpha- and delta sarcoglycan genes, respectively, leading to severe muscle weakness and degeneration. The cause of the disease has been well characterized and a number of animal models are available for pre-clinical studies to test potential therapeutic interventions. To facilitate transition from drug discovery to clinical trials, standardized procedures and natural disease history data were collected for these mouse models...
2017: PloS One
https://www.readbyqxmd.com/read/28796385/muscle-length-effect-on-corticospinal-excitability-during-maximal-concentric-isometric-and-eccentric-contractions-of-the-knee-extensors
#13
Valentin Doguet, Kazunori Nosaka, Arnaud Guével, Gary Thickbroom, Kazuhiro Ishimura, Marc Jubeau
Neural control of eccentric contractions differs from that of concentric and isometric contractions, but no previous study has compared responses to motor cortex stimulations at long muscle lengths during such contraction types. This study compared the effect of muscle length on corticospinal excitability between maximal concentric, isometric and eccentric contractions of the knee extensors. Twelve males performed 12 maximal concentric, isometric and eccentric voluntary contractions (36 contractions in total), separated by a 5-min rest between contraction types...
August 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28794193/sequential-hemifield-gating-of-alpha-and-beta-behavioral-performance-oscillations-after-microsaccades
#14
Joachim Bellet, Chih-Yang Chen, Ziad M Hafed
Microsaccades are tiny saccades that occur during gaze fixation. Even though visual processing has been shown to be strongly modulated close to the time of microsaccades, both at central and peripheral eccentricities, it is not clear how these eye movements might influence longer-term fluctuations in brain activity and behavior. Here we found that visual processing is significantly affected, and in a rhythmic manner, even several hundreds of milliseconds after a microsaccade. Human visual detection efficiency, as measured by reaction time, exhibited coherent rhythmic oscillations in the α and β frequency bands for up to ~650-700 ms after a microsaccade...
August 9, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28793798/dual-aav-gene-therapy-for-duchenne-muscular-dystrophy-with-a-7-kb-mini-dystrophin-gene-in-the-canine-model
#15
Kasun Kodippili, Chady Hakim, Xiufang Pan, Hsiao T Yang, Yongping YUe, Yadong Zhang, Jin-Hong Shin, Nora N Yang, Dongsheng Duan
Dual adeno-associated virus (AAV) technology was developed in 2000 to double the packaging capacity of the AAV vector. The proof-of-principle has been demonstrated in various mouse models. Yet, pivotal evidence is lacking in large animal models of human diseases. Here we report expression of a 7-kb canine ∆H2-R15 mini-dystrophin gene using a pair of dual AAV vectors in the canine model of Duchenne muscular dystrophy (DMD). The ∆H2-R15 minigene is by far the most potent synthetic dystrophin gene engineered for DMD gene therapy...
August 10, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28790474/possible-vascular-injury-due-to-screw-eccentricity-in-minimally-invasive-total-hip-arthroplasty
#16
Nishant Kumar Singh, Sanjay Kumar Rai, Amit Rastogi
BACKGROUND: Vascular injury during minimally invasive total hip arthroplasty (THA) is uncommon, yet a well-recognized and serious issue. It emerges because of non-visibility of vascular structures proximal to the pelvic bone during reaming, drilling holes, and fixing of screws. Numerous studies have found that screw fixation during cementless THA is beneficial for the initial stability of cup; yet, no anatomical guidelines support angular eccentric screw fixation. MATERIALS AND METHODS: In this study, we obtained the pelvic arterial-phase computed tomographic data of thirty eight humans and reconstructed the three-dimensional models of osseous and vessel structures...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28782679/task-modulates-functional-connectivity-networks-in-free-viewing-behavior
#17
Hossein Seidkhani, Andrey R Nikolaev, Radha Nila Meghanathan, Hamid Pezeshk, Ali Masoudi-Nejad, Cees van Leeuwen
In free visual exploration, eye-movement is immediately followed by dynamic reconfiguration of brain functional connectivity. We studied the task-dependency of this process in a combined visual search-change detection experiment. Participants viewed two (nearly) same displays in succession. First time they had to find and remember multiple targets among distractors, so the ongoing task involved memory encoding. Second time they had to determine if a target had changed in orientation, so the ongoing task involved memory retrieval...
August 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28780603/early-detection-of-exercise-induced-muscle-damage-using-elastography
#18
Lilian Lacourpaille, Antoine Nordez, François Hug, Valentin Doguet, Ricardo Andrade, Gaël Guilhem
PURPOSE: This study aimed to determine whether an increase in muscle shear modulus measured 30 min after eccentric exercise (30 min) reflects the magnitude of force deficit measured 48-h post-exercise (48 H). METHODS: A total of 53 healthy participants were distributed in five groups. Four groups performed either repeated eccentric elbow flexions or knee extensions at either a low or high load. A fifth group performed repeated concentric elbow flexions (control load)...
August 5, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28774070/friction-and-wear-reduction-of-eccentric-journal-bearing-made-of-sn-based-babbitt-for-ore-cone-crusher
#19
Auezhan Amanov, Byungmin Ahn, Moon Gu Lee, Yongho Jeon, Young-Sik Pyun
An anti-friction Babbitt alloy-coated bearing made by a casting process is a journal bearing, which is used in an ore cone crusher eccentric. The main purpose of the Babbitt coated eccentric is to provide a low friction to support and guide a rotating shaft. Despite the fact that the Babbitt-coated eccentric offers a low friction coefficient and can be operated without a continuous supply of lubricant, it suffers from mining environments and short service life. In this study, an ultrasonic nanocrystalline surface modification (UNSM) technique was used to further reduce the friction coefficient, to increase the wear resistance, and to extend the service life of the Sn-based Babbitt metal...
November 22, 2016: Materials
https://www.readbyqxmd.com/read/28772778/self-developed-testing-system-for-determining-the-temperature-behavior-of-concrete
#20
He Zhu, Qingbin Li, Yu Hu
Cracking due to temperature and restraint in mass concrete is an important issue. A temperature stress testing machine (TSTM) is an effective test method to study the mechanism of temperature cracking. A synchronous closed loop federated control TSTM system has been developed by adopting the design concepts of a closed loop federated control, a detachable mold design, a direct measuring deformation method, and a temperature deformation compensation method. The results show that the self-developed system has the comprehensive ability of simulating different restraint degrees, multiple temperature and humidity modes, and closed-loop control of multi-TSTMs during one test period...
April 16, 2017: Materials
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