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https://www.readbyqxmd.com/read/29053808/the-impact-of-supplemental-antioxidants-on-visual-function-in-nonadvanced-age-related-macular-degeneration-a-head-to-head-randomized-clinical-trial
#1
Kwadwo Owusu Akuffo, Stephen Beatty, Tunde Peto, Jim Stack, Jim Stringham, David Kelly, Irene Leung, Laura Corcoran, John M Nolan
Purpose: The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. Methods: In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29047676/wavelength-and-ambient-luminance-dependence-of-laser-eye-dazzle
#2
Craig A Williamson, Leon N McLin, J Michael Rickman, Michael A Manka, Paul V Garcia, Wesley T Kinerk, Peter A Smith
A series of experiments has been conducted to quantify the effects of laser wavelength and ambient luminance on the severity of laser eye dazzle experienced by human subjects. Eight laser wavelengths in the visible spectrum were used (458-647 nm) across a wide range of ambient luminance conditions (0.1-10,000  cd·m(-2)). Subjects were exposed to laser irradiance levels up to 600  μW·cm(-2) and were asked to recognize the orientation of optotypes at varying eccentricities up to 31.6 deg of visual angle from the laser axis...
October 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29046828/exploring-test-retest-variability-using-high-resolution-perimetry
#3
Takuya Numata, Ted Maddess, Chota Matsumoto, Sachiko Okuyama, Shigeki Hashimoto, Hiroki Nomoto, Yoshikazu Shimomura
PURPOSE: Test-retest variability (TRV) of visual field (VF) data seriously degrades our capacity to recognize true VF progression. We conducted repeated high-resolution perimetry with a test interval of 0.5° to investigate the sources of TRV. In particular, we examined whether the spatial variance of the observed sensitivity changes or if their absolute magnitude was of more importance. METHODS: Sixteen eyes of 16 glaucoma patients were each tested three times at 61 VF locations along the superior-temporal 45° meridian using a modified protocol of the Octopus 900 perimeter...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29046631/development-of-a-bayesian-estimator-for-audio-visual-integration-a-neurocomputational-study
#4
Mauro Ursino, Andrea Crisafulli, Giuseppe di Pellegrino, Elisa Magosso, Cristiano Cuppini
The brain integrates information from different sensory modalities to generate a coherent and accurate percept of external events. Several experimental studies suggest that this integration follows the principle of Bayesian estimate. However, the neural mechanisms responsible for this behavior, and its development in a multisensory environment, are still insufficiently understood. We recently presented a neural network model of audio-visual integration (Neural Computation, 2017) to investigate how a Bayesian estimator can spontaneously develop from the statistics of external stimuli...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29045331/test-conditions-in-macular-visual-field-testing-in-glaucoma
#5
Mariko Eura, Chota Matsumoto, Shigeki Hashimoto, Sachiko Okuyama, Sonoko Takada, Hiroki Nomoto, Fumi Tanabe, Yoshikazu Shimomura
PURPOSE: To evaluate the suitable visual field (VF) test conditions (target size, test type, and eccentricity) for the macular region, we investigated the correlations between the ganglion cell layer (GCL) thickness and six VF test results. METHODS: We tested 32 eyes of patients (61.1±9.2 y) with preperimetric (6), early-stage (16), and moderate-stage (10) glaucoma. The VF tests included 3 SAP (the 10-2 HFA using SITA with target size III [HFA SITA (III)], full threshold with size III [HFA FULL (III)] and size I [HFA FULL (I)]) and 3 visual function-specific perimetry tests (the 10-2 SWAP, 10-2 flicker, and 10-2 Humphrey Matrix)...
October 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29044804/comparison-of-visual-receptive-fields-in-the-dorsolateral-prefrontal-cortex-dlpfc-and-ventral-intraparietal-area-vip-in-macaques
#6
Pooja Viswanathan, Andreas Nieder
The concept of receptive field (RF) describes the responsiveness of neurons to sensory space. Neurons in the primate association cortices have long been known to be spatially selective but a detailed characterization and direct comparison of RFs between frontal and parietal association cortices is missing. We sampled the RFs of a large number of neurons from two interconnected areas of the frontal and parietal lobes, the dorsolateral prefrontal cortex (dlPFC) and ventral intraparietal area (VIP), of rhesus monkeys by systematically presenting a moving bar during passive fixation...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29043565/eccentric-macular-hole-after-pars-plana-vitrectomy-for-epiretinal-membrane-without-internal-limiting-membrane-peeling-a-case-report
#7
Christina Garnavou-Xirou, Tina Xirou, Stamatina Kabanarou, Ilias Gkizis, Stavros Velissaris, Irini Chatziralli
INTRODUCTION: Postoperative eccentric macular hole formation is an uncommon complication after pars plana vitrectomy (PPV) without internal limiting membrane (ILM) peeling for the treatment of epiretinal membrane (ERM). We present a case of eccentric macular hole formation after PPV for ERM without ILM peeling. CASE REPORT: A 68-year-old male patient presented with ERM and visual acuity of 6/24 in his left eye. He underwent 23-gauge PPV without ILM peeling for treatment of ERM...
October 17, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29039798/the-effect-of-taurine-on-the-recovery-from-eccentric-exercise-induced-muscle-damage-in-males
#8
Yanita McLeay, Stephen Stannard, Matthew Barnes
Eccentric exercise is known to bring about microstructural damage to muscle, initiating an inflammatory cascade involving various reactive oxygen species. This, in turn, can significantly impair physical performance over subsequent days. Taurine, a powerful endogenous antioxidant, has previously been shown to have a beneficial effect on muscle damage markers and recovery when taken for a few days to several weeks prior to eccentric exercise. However, to date no studies have looked at the effects of supplementing over the days following eccentric exercise on performance recovery...
October 17, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29038526/strain-in-shock-loaded-skeletal-muscle-and-the-time-scale-of-muscular-wobbling-mass-dynamics
#9
Kasper B Christensen, Michael Günther, Syn Schmitt, Tobias Siebert
In terrestrial locomotion, muscles undergo damped oscillations in response to limb impacts with the ground. Muscles are also actuators that generate mechanical power to allow locomotion. The corresponding elementary contractile process is the work stroke of an actin-myosin cross-bridge, which may be forcibly detached by superposed oscillations. By experimentally emulating rat leg impacts, we found that full activity and non-fatigue must meet to possibly prevent forcible cross-bridge detachment. Because submaximal muscle force represents the ordinary locomotor condition, our results show that forcible, eccentric cross-bridge detachment is a common, physiological process even during isometric muscle contractions...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038027/tumor-necrosis-factor-alpha-and-soluble-tnf-alpha-receptor-responses-in-young-vs-middle-aged-males-following-eccentric-exercise
#10
Eliott Arroyo, Adam J Wells, Joseph A Gordon, Alyssa N Varanoske, Yftach Gepner, Nicholas A Coker, David D Church, David H Fukuda, Jeffrey R Stout, Jay R Hoffman
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) has been shown to be implicated in both muscle regeneration and muscle wasting. However, it remains unclear whether TNF-α is responsible for the age-related losses in muscle size and function. Also, due to the high clearance rate of TNF-α from circulation, analyzing the circulating levels of soluble TNF-α receptors 1 and 2 (STNFR1 and STNFR2) may provide a better indication of inflammatory events. The aim of this study was to examine changes in circulating concentrations of TNF-α, STNFR1, and STNFR2 following acute eccentric exercise in young (YA) and middle-aged (MA) men...
October 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29037794/ventricular-performance-is-associated-with-need-for-extracorporeal-membrane-oxygenation-in-newborns-with-congenital-diaphragmatic-hernia
#11
Gabriel Altit, Shazia Bhombal, Krisa Van Meurs, Theresa A Tacy
OBJECTIVE: To compare echocardiography (ECHO) findings of patients with congenital diaphragmatic hernia (CDH) who required extracorporeal membrane oxygenation (ECMO) to non-ECMO treated patients. STUDY DESIGN: We reviewed clinical and ECHO data of newborns with CDH born between 2009 and 2016. Exclusions included major anomalies, genetic syndromes, or no ECHO prior to ECMO. Pulmonary hypertension was assessed by ductal shunting and tricuspid regurgitant jet. Speckle tracking echocardiography (STE) assessed function by quantifying deformation...
October 13, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29037636/effects-of-kinesio-taping-%C3%A2-on-knee-function-and-pain-in-athletes-with-patellofemoral-pain-syndrome
#12
Elaheh Aghapour, Fahimeh Kamali, Ehsan Sinaei
OBJECTIVE: To compare the knee performance and pain in athletes with patellofemoral pain syndrome (PFPS) before and after applying Kinesio Tape(®) (KT) on vastus medialis obliquus (VMO) muscle. PARTICIPANTS: Fifteen participants (10 females, five males) with unilateral PFPS were examined and compared under taped and untaped conditions. INTERVENTION: VMO of the involved leg was taped from origin to insertion, with 75% of KT's maximal length tension...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29035982/comparison-of-the-effect-of-5-different-treatment-options-for-managing-patellar-tendinopathy-a-secondary-analysis
#13
Dafne van Rijn, Inge van den Akker-Scheek, Mirjam Steunebrink, Ron L Diercks, Johannes Zwerver, Henk van der Worp
OBJECTIVE: Currently, no treatments exist for patellar tendinopathy (PT) that guarantee quick and full recovery. Our objective was to assess which treatment option provides the best chance of clinical improvement and to assess the influence of patient and injury characteristics on the clinical effect of these treatments. DESIGN: A secondary analysis was performed on the combined databases of 3 previously performed double-blind randomized controlled trials. PATIENTS: In total, 138 patients with PT were included in the analysis...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29035598/rpe-during-concentric-and-eccentric-cycling-are-we-measuring-effort-or-exertion
#14
Luis Peñailillo, Karen Mackay, Chris R Abbiss
Despite the terms often being used interchangeably it has been suggested that perceptions of effort and perceptions of exertion may differ. Eccentric cycling may provide a model of exercise by which differences between these perceptions can be examined. PURPOSE: of this study was to examine and compare perceptions of effort and exertion during eccentric and concentric cycling at four intensities. METHODS: Ten healthy male participants (mean ± SD; age: 29.8 ± 2...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29034027/retrograde-use-of-frontrunner-catheter-in-superficial-femoral-artery-for-flushing-long-segment-occlusions-involving-distal-common-femoral-artery
#15
Nelson Chavarria, Tae-Hoon Kim, Michael Azrin, Juyong Lee
We present the case of an 81-year-old female with flush occlusion of the superficial femoral artery (SFA) and percutaneous transluminal angioplasty. Initially, the antegrade approach failed due to flush occlusion without stump. Hard, round surfaced, calcific, and eccentric plaque of the ostium of SFA was also present, which involved distal common femoral artery (CFA). Thus, we successfully used a Frontrunner catheter for retrograde reentry at the lower position of the CFA. Various treatment strategies involving Frontrunner and atherectomy devices could make percutaneous procedures possible in femoropopliteal occlusive disease, involving the CFA...
March 24, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032518/synchronous-solitary-calvarial-yolk-sac-tumor-metastasis-as-the-initial-presentation-of-mediastinal-germ-cell-tumor
#16
Kirti Gupta, Madhivanan Karthigeyan, Ayushman Satapathy, Pravin Salunke
INTRODUCTION: In children, malignant tumors presenting as a calvarial mass that too as initial manifestation are unusual. Also, brain metastases per se are rare in pediatric solid tumors with an incidence of just 1.5%. CASE DESCRIPTION: We present a child with calvarial metastasis which was the presenting symptom of an otherwise asymptomatic large malignant mediastinal germ cell tumor (GCT). The lesion was dural-based involving both calvaria as well as the underlying brain parenchyma...
October 14, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29030476/added-value-of-vessel-wall-magnetic-resonance-imaging-for-differentiation-of-nonocclusive-intracranial-vasculopathies
#17
Mahmud Mossa-Basha, Dean K Shibata, Danial K Hallam, Adam De Havenon, Daniel S Hippe, Kyra J Becker, David L Tirschwell, Thomas Hatsukami, Niranjan Balu, Chun Yuan
BACKGROUND AND PURPOSE: Our goal is to determine the added value of intracranial vessel wall magnetic resonance imaging (IVWI) in differentiating nonocclusive vasculopathies compared with luminal imaging alone. METHODS: We retrospectively reviewed images from patients with both luminal and IVWI to identify cases with clinically defined intracranial vasculopathies: atherosclerosis (intracranial atherosclerotic disease), reversible cerebral vasoconstriction syndrome, and inflammatory vasculopathy...
October 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29030345/runx1-deficiency-protects-against-adverse-cardiac-remodeling-following-myocardial-infarction
#18
Charlotte S McCarroll, Weihong He, Kirsty Foote, Ashley Bradley, Karen McGlynn, Francesca Vidler, Colin Nixon, Katrin Nather, Caroline Fattah, Alexandra H Riddell, Peter Bowman, Elspeth B Elliott, Margaret Bell, Catherine Hawksby, Scott M MacKenzie, Liam J Morrison, Anne Terry, Karen Blyth, Godfrey L Smith, Martin W McBride, Thomas Kubin, Thomas Braun, Stuart A Nicklin, Ewan R Cameron, Christopher M Loughrey
Background -Myocardial infarction (MI) is a leading cause of heart failure and death worldwide. Preservation of contractile function and protection against adverse changes in ventricular architecture (cardiac remodeling) are key factors to limiting progression of this condition to heart failure. Consequently, new therapeutic targets are urgently required to achieve this aim. Expression of the Runx1 transcription factor is increased in adult cardiomyocytes following MI; however, the functional role of Runx1 in the heart is unknown...
October 13, 2017: Circulation
https://www.readbyqxmd.com/read/29027696/computer-aided-evaluation-of-blood-vessel-geometry-from-acoustic-images
#19
Stefan B Lindström, Fredrik Uhlin, Niclas Bjarnegård, Micael Gylling, Kamilla Nilsson, Christina Svensson, Pia Yngman-Uhlin, Toste Länne
A method for computer-aided assessment of blood vessel geometries based on shape-fitting algorithms from metric vision was evaluated. Acoustic images of cross sections of the radial artery and cephalic vein were acquired, and medical practitioners used a computer application to measure the wall thickness and nominal diameter of these blood vessels with a caliper method and the shape-fitting method. The methods performed equally well for wall thickness measurements. The shape-fitting method was preferable for measuring the diameter, since it reduced systematic errors by up to 63% in the case of the cephalic vein because of its eccentricity...
October 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29020108/influence-of-sports-flooring-and-shoes-on-impact-forces-and-performance-during-jump-tasks
#20
Laurent Malisoux, Paul Gette, Axel Urhausen, Joao Bomfim, Daniel Theisen
We aim to determine the influence of sports floorings and sports shoes on impact mechanics and performance during standardised jump tasks. Twenty-one male volunteers performed ankle jumps (four consecutive maximal bounds with very dynamic ankle movements) and multi-jumps (two consecutive maximal counter-movement jumps) on force plates using minimalist and cushioned shoes under 5 sports flooring (SF) conditions. The shock absorption properties of the SF, defined as the proportion of peak impact force absorbed by the tested flooring when compared with a concrete hard surface, were: SF0 = 0% (no flooring), SF1 = 19%, SF2 = 26%, SF3 = 37% and SF4 = 45%...
2017: PloS One
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