Yike Zhu, Matthew Ackers-Johnson, Muthu K Shanmugam, Leroy Sivappiragasam Pakkiri, Chester Lee Drum, Yanpu Chen, Johnny Kim, Wyatt G Paltzer, Ahmed I Mahmoud, Wilson Lek Wen Tan, Mick Chang Jie Lee, Jianming Jiang, Danh Anh Tuan Luu, Shi Ling Ng, Peter Yi Qing Li, Anhui Wang, Rong Qi, Gabriel Jing Xiang Ong, Timothy Ng Yu, Jody J Haigh, Zenia Tiang, A Mark Richards, Roger Foo
BACKGROUND: Adult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the potential for heart regeneration. Endogenous cardiomyocyte proliferation is preceded by cardiomyocyte dedifferentiation (CMDD), wherein adult cardiomyocytes revert to a less matured state that is distinct from the classical myocardial fetal stress gene response associated with heart failure. However, very little is known about CMDD as a defined cardiomyocyte cell state in transition...
April 8, 2024: Circulation