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https://www.readbyqxmd.com/read/28106506/ectodysplasin-a-in-biological-fluids-and-diagnosis-of-ectodermal-dysplasia
#1
J Podzus, C Kowalczyk-Quintas, S Schuepbach-Mallepell, L Willen, G Staehlin, M Vigolo, A Tardivel, D Headon, N Kirby, M L Mikkola, H Schneider, P Schneider
The tumor necrosis factor (TNF) family ligand ectodysplasin A (EDA) is produced as 2 full-length splice variants, EDA1 and EDA2, that bind to EDA receptor (EDAR) and X-linked EDA receptor (XEDAR/EDA2R), respectively. Inactivating mutations in Eda or Edar cause hypohidrotic ectodermal dysplasia (HED), a condition characterized by malformations of the teeth, hair and glands, with milder deficiencies affecting only the teeth. EDA acts early during the development of ectodermal appendages-as early as the embryonic placode stage-and plays a role in adult appendage function...
February 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28101802/cold-pcr-technologies-in-the-area-of-personalized-medicine-methodology-and-applications
#2
REVIEW
Florence Mauger, Alexandre How-Kit, Jörg Tost
Somatic mutations bear great promise for use as biomarkers for personalized medicine, but are often present only in low abundance in biological material and are therefore difficult to detect. Many assays for mutation analysis in cancer-related genes (hotspots) have been developed to improve diagnosis, prognosis, prediction of drug resistance, and monitoring of the response to treatment. Two major approaches have been developed: mutation-specific amplification methods and methods that enrich and detect mutations without prior knowledge on the exact location and identity of the mutation...
January 18, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28095377/associations-of-maternal-leptin-with-neonatal-adiposity-differ-according-to-pregravid-weight
#3
Julie Patenaude, Guillaume Lacerte, Marilyn Lacroix, Laetitia Guillemette, Catherine Allard, Myriam Doyon, Marie-Claude Battista, Julie Moreau, Julie Ménard, Jean-Luc Ardilouze, Patrice Perron, Marie-France Hivert
BACKGROUND: During pregnancy, maternal circulating leptin is released by maternal adipose tissue and the placenta, and may have a role in fetal development. OBJECTIVES: We investigated maternal leptinemia and glycemia associations with neonatal adiposity, taking into account pregravid weight status. METHODS: We included 235 pregnant women from the Genetics of Glucose Regulation in Gestation and Growth prospective cohort with data: blood samples collected during the 2nd trimester, an oral glucose tolerance test (OGTT), and the measured leptin and glucose levels...
January 18, 2017: Neonatology
https://www.readbyqxmd.com/read/28089504/review-nutrient-sulfate-supply-from-mother-to-fetus-placental-adaptive-responses-during-human-and-animal-gestation
#4
REVIEW
P A Dawson, K Richard, A Perkins, Z Zhang, D G Simmons
Nutrient sulfate has numerous roles in mammalian physiology and is essential for healthy fetal growth and development. The fetus has limited capacity to generate sulfate and relies on sulfate supplied from the maternal circulation via placental sulfate transporters. The placenta also has a high sulfate requirement for numerous molecular and cellular functions, including sulfate conjugation (sulfonation) to estrogen and thyroid hormone which leads to their inactivation. Accordingly, the ratio of sulfonated (inactive) to unconjugated (active) hormones modulates endocrine function in fetal, placental and maternal tissues...
January 4, 2017: Placenta
https://www.readbyqxmd.com/read/28081266/human-extravillous-trophoblasts-penetrate-decidual-veins-and-lymphatics-before-remodeling-spiral-arteries-during-early-pregnancy
#5
Nannan He, Liesbeth van Iperen, Danielle de Jong, Karoly Szuhai, Frans M Helmerhorst, Lucette A J van der Westerlaken, Susana M Chuva de Sousa Lopes
In humans, the defective invasion of the maternal endometrium by fetal extravillous trophoblasts (EVTs) can lead to insufficient perfusion of the placenta, resulting in pregnancy complications that can put both mother and baby at risk. To study the invasion of maternal endometrium between (W)5.5-12 weeks of gestation by EVTs, we combined fluorescence in situ hybridization, immunofluorescence and immunohistochemistry to determine the presence of (male) EVTs in the vasculature of the maternal decidua. We observed that interstitial mononuclear EVTs directly entered decidual veins and lymphatics from W5...
2017: PloS One
https://www.readbyqxmd.com/read/28079822/successfully-treated-congenital-cystic-adenomatoid-malformation-by-open-fetal-surgery-a-care-compliant-case-report-of-a-5-year-follow-up-and-review-of-the-literature
#6
Dazhi Fan, Shuzhen Wu, Rui Wang, Yi Huang, Yao Fu, Wen Ai, Meng Zeng, Xiaoling Guo, Zhengping Liu
BACKGROUND: Congenital cystic adenomatoid malformation (CCAM) is a rare hamartomatous cystic lesion. Open fetal surgery currently provides a potential therapeutic option for management of a fetus with CCAM diagnosis. CASE SUMMARY: A 22-year-old G2P0 woman presented at (Equation is included in full-text article.)weeks' gestation for evaluation of a fetus with a left lung lesion and diagnosed as CCAM at (Equation is included in full-text article.)weeks' gestation...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28077176/main-pulmonary-artery-cross-section-ratio-is-low-in-fetuses-with-tetralogy-of-fallot-and-ductus-arteriosus-dependent-pulmonary-circulation
#7
Hironori Ebishima, Kenichi Kurosaki, Jun Yoshimatsu, Isao Shiraishi
OBJECTIVES: This study aimed to determine fetal echocardiographic features of tetralogy of Fallot in association with postnatal outcomes. METHODS: The Z-scores of the main and bilateral pulmonary arteries and the aorta were measured, and the following variables were calculated in 13 fetuses with tetralogy of Fallot: pulmonary artery-to-aorta ratio and main pulmonary artery cross-section ratio - the main pulmonary artery diameter squared divided by the sum of the diameter squared of the left and right pulmonary arteries...
January 12, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28062543/multiple-slc-and-abc-transporters-contribute-to-the-placental-transfer-of-entecavir
#8
Zhiyuan Ma, Xi Yang, Ting Jiang, Mengru Bai, Caihong Zheng, Su Zeng, Dongli Sun, Huidi Jiang
Entecavir (ETV), a nucleoside analogue with high efficacy against hepatitis B virus, is recommended as a first-line antiviral drug for the treatment of chronic hepatitis B. However, scant information is available on the use of ETV in pregnancy. To better understand the safety of ETV in pregnant women, we aimed to demonstrate whether ETV could permeate placental barrier and the underlying mechanism. Our study showed that small amount of ETV could permeate across placenta in mice. ETV accumulation in activated or non-activated BeWo cells (treated with or without forskolin) was sharply reduced in the presence of 100 μM of adenosine, cytidine and in Na+ free medium, indicating that nucleoside transporters possibly mediate the uptake of ETV...
January 6, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28049898/developmental-toxicity-of-nanoparticles-on-the-brain
#9
Masakazu Umezawa, Atsuto Onoda, Ken Takeda
 The toxicity of nanoparticles (nanotoxicology) is being investigated to understand both the health impacts of atmospheric ultrafine particles-the size of which is a fraction (<0.1 μm aerodynamic diameter) of that of PM2.5 (<2.5 μm diameter)-and the safer use of engineered nanomaterials. Developmental toxicity of nanoparticles has been studied since their transfer from pregnant body to fetal circulation and offspring body was first reported. Here we reviewed the developmental toxicity of nanoparticles on the brain, one of the most important organs in maintenance of mental health and high quality of life...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28043363/time-dependent-changes-in-pregnancy-associated-glycoproteins-and-progesterone-in-commercial-crossbred-sheep
#10
J N Roberts, K J May, A Veiga-Lopez
The ruminant placenta functions as an endocrine and paracrine organ secreting proteins, growth factors, and steroid hormones, including pregnancy-associated glycoproteins (PAG), proteins with elusive function, which are readily detectable in maternal serum after placental attachment. In sheep, circulating progesterone beyond gestational Day 50 is predominantly of placental origin. The relationship among placental secreted factors, including progesterone, remains uncertain in sheep. The first aim of the study was to determine the relationship between gestational PAG profiles-using two commercial ELISA assays-progesterone, and fetal growth during pregnancy...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28031376/vitamin-b-6-status-in-unsupplemented-pregnant-women-is-associated-positively-with-serum-docosahexaenoic-acid-and-inversely-with-the-n-6-to-n-3-fatty-acid-ratio
#11
Maria F Mujica-Coopman, Ana B Franco-Sena, Dayana R Farias, Juliana S Vaz, Alex Brito, Gilberto Kac, Yvonne Lamers
BACKGROUND: Vitamin B-6-deficient diets decrease plasma docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (AA) concentrations in healthy adults. These fatty acids (FAs) are important for fetal neurodevelopment, but the relation between vitamin B-6 status and circulating polyunsaturated FAs (PUFAs) during pregnancy is unknown. OBJECTIVE: We sought to assess the relation between plasma pyridoxal 5' phosphate (PLP; the active form of vitamin B-6) and serum DHA, EPA, AA, linoleic acid, eicosadienoic, and α-linolenic acid concentrations during pregnancy...
December 28, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/28029359/computational-modeling-of-the-structure-function-relationship-in-human-placental-terminal-villi
#12
R Plitman Mayo, J Olsthoorn, D S Charnock-Jones, G J Burton, M L Oyen
Placental oxygen transport takes place at the final branches of the villous tree and is dictated by the relative arrangement of the maternal and fetal circulations. Modeling techniques have failed to accurately assess the structure-function relationship in the terminal villi due to the geometrical complexity. Three-dimensional blood flow and oxygen transport was modeled in four terminal villi reconstructed from confocal image stacks. The blood flow was analyzed along the center lines of capillary segments and the effect of the variability in capillary diameter, tortuosity and branching was investigated...
October 12, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28028317/oral-leptin-supplementation-throughout-lactation-in-rats-prevents-later-metabolic-alterations-caused-by-gestational-calorie-restriction
#13
N Szostaczuk, T Priego, M Palou, A Palou, C Picó
OBJECTIVES: Calorie-restriction during gestation in rats has been seen to produce lasting detrimental effects in the offspring, affecting energy balance control and other related metabolic functions. Our aim was to assess whether leptin supplementation throughout lactation may prevent the dysmetabolic phenotype in adulthood associated with gestational calorie restriction. METHODS: Three groups of male Wistar rats were followed: the offspring of ad libitum fed dams (controls); the offspring of 20% calorie-restricted dams during gestation (CR); and CR rats supplemented with physiological doses of leptin throughout lactation (CR-Leptin)...
December 28, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28024810/transplacental-transfer-of-polycyclic-aromatic-hydrocarbons-in-paired-samples-of-maternal-serum-umbilical-cord-serum-and-placenta-in-shanghai-china
#14
Xiaolan Zhang, Xiaojing Li, Ye Jing, Xiangming Fang, Xinyu Zhang, Bingli Lei, Yingxin Yu
Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is a high-priority public health concern. However, maternal to fetal transplacental transfer of PAHs has not been systematically studied. To investigate the transplacental transfer of PAHs from mother to fetus and determine the influence of lipophilicity (octanol-water partition coefficient, KOW) on transfer process, in the present study, we measured the concentrations of 15 PAHs in 95 paired maternal and umbilical cord serum, and placenta samples (in total 285 samples) collected in Shanghai, China...
December 23, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/28012450/exploring-sexual-dimorphism-in-placental-circulation-at-22-24-weeks-of-gestation-a-cross-sectional-observational-study
#15
Christian Widnes, Kari Flo, Ganesh Acharya
INTRODUCTION: Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS: This was a prospective cross-sectional study of 520 healthy pregnant women. Blood flow velocities of the middle cerebral artery (MCA), umbilical artery (UA), umbilical vein (UV) and the uterine arteries (UtA) were measured using Doppler ultrasonography...
January 2017: Placenta
https://www.readbyqxmd.com/read/28012077/retrospective-cohort-study-amh-is-the-best-ovarian-reserve-markers-in-predicting-ovarian-response-but-has-unfavorable-value-in-predicting-clinical-pregnancy-in-gnrh-antagonist-protocol
#16
Huiyu Xu, Lin Zeng, Rui Yang, Ying Feng, Rong Li, Jie Qiao
BACKGROUND: Various ovarian reserve markers have been used to predict ovarian response and pregnancy. However, concerning Chinese population, fewer trials have been performed using the combined ovarian reserve markers to predict ovarian response and pregnancy in GnRH antagonist protocols. METHODS: Data from a total of 373 patients' in vitro fertilization cycles using GnRH antagonist protocol was retrospectively included. According to our center's daily practice, circulating follicle-stimulating hormone, luteinizing hormone, and estradiol (E2) were tested on menstrual cycle day 2-4 or hCG trigger day, and the concentration of AMH was determined despite of menstrual cycle...
December 23, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28011759/-end-stage-heart-failure-therapy-potential-lessons-from-congenital-heart-disease-from-pulmonary-artery-banding-and-interatrial-communication-to-parallel-circulation
#17
REVIEW
Dietmar Schranz, Hakan Akintuerk, Norbert F Voelkel
The final therapy of 'end-stage heart failure' is orthotopic heart, lung or heart-lung transplantation. However, these options are not available for many patients worldwide. Therefore, novel therapeutical strategies are needed. Based on pathophysiological insights regarding (1) the long-term impact of an obstructive pulmonary outflow tract in neonates with congenitally corrected transposition of the great arteries, (2) the importance of a restrictive versus a non-restrictive atrial septum in neonates born with a borderline left ventricle and (3) the significance of both, a patent foramen ovale and/or open ductus arteriosus for survival of newborns with persistent pulmonary hypertension, the current review introduces some therapeutical strategies that may be applicable to selected patients with heart failure...
December 23, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28009774/effect-of-plasmapheresis-and-passage-of-anti-retinal-antibodies-through-the-placenta-in-a-case-of-non-paraneoplastic-autoimmune-retinopathy
#18
David I Sierpina, David M Skale, Joseph T Fan
PURPOSE: To present a case of nonparaneoplastic autoimmune retinopathy in association with myasthenia gravis in a young woman, and to report the effect of plasmapheresis as well as passage of antiretinal antibodies through the placenta. METHODS: Case report. RESULTS: A 31-year-old woman presented with a history of myasthenia gravis and rapidly progressive vision loss at the age of 23. Funduscopic appearance and fluorescein angiographic findings on presentation were consistent with an autoimmune retinopathy...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28008608/increasing-pulmonary-blood-flow-at-birth-the-nerve-of-the-baby
#19
Noah H Hillman
The transition from a fetus to a newborn infant is one of the most dramatic and important physiologic changes in an individual's life. With the cutting of the umbilical cord, the fetus must almost instantly convert to newborn physiology, which relies on efficient gas exchange in the lungs, energy metabolism in the liver, and thermoregulation through brown fat (Hillman et al., 2012). The most crucial of these physiologic shifts at birth is the transition from the fetal circulator pattern to normal dual ventricular physiology (Hooper et al...
December 23, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/28007981/frontline-science-myeloid-derived-suppressor-cells-mdscs-facilitate-maternal-fetal-tolerance-in-mice
#20
Suzanne Ostrand-Rosenberg, Pratima Sinha, Chas Figley, Ramses Long, DoHwan Park, Darryl Carter, Virginia K Clements
During successful pregnancy, a woman is immunologically tolerant of her genetically and antigenically disparate fetus, a state known as maternal-fetal tolerance. How this state is maintained has puzzled investigators for more than half a century. Diverse, immune and nonimmune mechanisms have been proposed; however, these mechanisms appear to be unrelated and to act independently. A population of immune suppressive cells called myeloid-derived suppressor cells (MDSCs) accumulates in pregnant mice and women. Given the profound immune suppressive function of MDSCs, it has been suggested that this cell population may facilitate successful pregnancy by contributing to maternal-fetal tolerance...
December 22, 2016: Journal of Leukocyte Biology
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