keyword
MENU ▼
Read by QxMD icon Read
search

Dynamed

keyword
https://www.readbyqxmd.com/read/29169224/epigenetic-control-of-oxidative-stresses-by-histone-acetyltransferases-in-candida-albicans
#1
REVIEW
Jueun Kim, Shinae Park, Jung-Shin Lee
Candida albicans is a major pathogenic fungus in human, and meets at first the innate immune cells, such as macrophage, in its host. One important strategy of the host cell to kill C. albicans is to produce reactive oxygen species (ROS) by the macrophages. In response to ROS produced by the macrophage, C. albicans operates its defense mechanisms against reactive oxygen species by expressing its oxidative stress response genes. Although there have been many researches explaining the specific transcription factors and the expression of the oxidative stress genes in C...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29169203/dissipation-residues-and-risk-assessment-of-spirotetramat-and-its-four-metabolites-in-citrus-and-soil-under-field-conditions-by-lc-ms-ms
#2
Qingtao Zhang, Yuling Chen, Shouyi Wang, Yurong Yu, Ping Lu, Deyu Hu, Zaihui Yang
A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method for the simultaneous determination of spirotetramat and its four metabolite residues in citrus, peel, pulp and soil was developed and validated by liquid chromatography with tandem mass spectrometry (LC-MS/MS). The samples were extracted with acetonitrile (1%, glacial acetic acid, v/v) and purified using primary secondary amine and octadecylsilane. The limit of detection was 0.01-0.13 mg/kg, whereas that of quantification was 0.02-0...
November 23, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29169135/nitrogen-removal-capacity-and-bacterial-community-dynamics-of-a-canon-biofilter-system-at-different-organic-matter-concentrations
#3
María J García-Ruiz, Paula Maza-Márquez, Jesús González-López, Francisco Osorio
Three Canon bench-scale bioreactors with a volume of 2 L operating in parallel were configured as submerged biofilters. In the present study we investigated the effects of a high ammonium concentration (320 mgNH4(+)· L(-1)) and different concentrations of organic matter (0, 100 and 400 mgCOD·L(-1)) on the nitrogen removal capacity and the bacterial community structure. After 60 days, the Canon biofilters operated properly under concentrations of 0 and 100 mgCOD·L(-1) of organic matter, with nitrogen removal efficiencies up to 85%...
November 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/29169130/can-liming-reduce-cadmium-cd-accumulation-in-rice-oryza-sativa-in-slightly-acidic-soils-a-contradictory-dynamic-equilibrium-between-cd-uptake-capacity-of-roots-and-cd-immobilisation-in-soils
#4
Yongjie Yang, Jiangmin Chen, Qina Huang, Shaoqing Tang, Jianlong Wang, Peisong Hu, Guosheng Shao
Cadmium (Cd) accumulation in rice is strongly controlled by liming, but information on the use of liming to control Cd accumulation in rice grown in slightly acidic soils is inconsistent. Here, pot experiments were carried out to investigate the mechanisms of liming on Cd accumulation in two rice varieties focusing on two aspects: available/exchangeable Cd content in soils that were highly responsive to liming, and Cd uptake and transport capacity in the roots of rice in terms of Cd accumulation-relative gene expression...
November 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/29169110/disorder-of-gut-amino-acids-metabolism-during-ckd-progression-is-related-with-gut-microbiota-dysbiosis-and-metagenome-change
#5
Yang Liu, Jianping Li, Jingao Yu, Yingyi Wang, Jingbo Lu, Er-Xin Shang, Zhenhua Zhu, Jianming Guo, Jinao Duan
Chronic kidney disease (CKD) is a worldwide public health problem. Uremic retention solutes such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are accumulated in CKD patients and are associated with the incidence of CKD progression. Amino acids are the major precursors of uremic retention solutes in gut. The dynamic change of amino acid metabolism in the gut during CKD progression has not been reported previously. In this paper, we studied the dynamic change of gut IS/PCS precursor and amino acid metabolism profile during CKD progression in 5/6 nephrectomized (5/6Nx) rats model...
November 15, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169086/linking-dynamic-patterns-of-neural-activity-in-orbitofrontal-cortex-with-decision-making
#6
REVIEW
Erin L Rich, Frederic M Stoll, Peter H Rudebeck
Humans and animals demonstrate extraordinary flexibility in choice behavior, particularly when deciding based on subjective preferences. We evaluate options on different scales, deliberate, and often change our minds. Little is known about the neural mechanisms that underlie these dynamic aspects of decision-making, although neural activity in orbitofrontal cortex (OFC) likely plays a central role. Recent evidence from studies in macaques shows that attention modulates value responses in OFC, and that ensembles of OFC neurons dynamically signal different options during choices...
November 20, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29169074/flow-stagnation-volume-and-abdominal-aortic-aneurysm-growth-insights-from-patient-specific-computational-flow-dynamics-of-lagrangian-coherent-structures
#7
Florian Joly, Gilles Soulez, Damien Garcia, Simon Lessard, Claude Kauffmann
Abdominal aortic aneurysms (AAA) are localized, commonly-occurring dilations of the aorta. When equilibrium between blood pressure (loading) and wall mechanical resistance is lost, rupture ensues, and patient death follows, if not treated immediately. Experimental and numerical analyses of flow patterns in arteries show direct correlations between wall shear stress and wall mechano-adaptation with the development of zones prone to thrombus formation. For further insights into AAA flow topology/growth interaction, a workout of patient-specific computational flow dynamics (CFD) is proposed to compute finite-time Lyapunov exponents and extract Lagrangian-coherent structures (LCS)...
November 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29169037/a-nephron-model-for-study-of-drug-induced-acute-kidney-injury-and-assessment-of-drug-induced-nephrotoxicity
#8
Yueyang Qu, Fan An, Yong Luo, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin
In this study, we developed a multilayer microfluidic device to simulate nephron, which was formed by "glomerulus", "Bowman's capsule", "proximal tubular lumen" and "peritubular capillary". In this microdevice, artificial renal blood flow was circulating and glomerular filtrate flow was single passing through, mimicking the behavior of a nephron. In this dynamic artificial nephron, we observed typical renal physiology, including the glomerular size-selective barrier, glomerular basement membrane charge-selective barrier, glucose reabsorption and para-aminohippuric acid secretion...
November 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/29169026/structures-and-mechanisms-in-clay-nanopore-trapping-of-structurally-different-fluoroquinolone-antimicrobials
#9
Fanny E K Okaikue-Woodi, Sabrina E Kelch, Michael P Schmidt, Carmen Enid Martinez, Randall E Youngman, Ludmilla Aristilde
Smectite clay nanoparticles are implicated in the retention of antimicrobials within soils and sediments; these clays are also inspected as drug carriers in physiological systems. Cation exchange is considered the primary adsorption mechanism of antimicrobials within smectite nanopores. However, a dual role of acid-base chemistry and adsorptive structures is speculated by recent studies. Using the prototypical smectite clay montmorillonite, we employed a combination of X-ray diffraction (XRD), nuclear magnetic resonance, attenuated total reflectance-Fourier transform infrared spectroscopy, and molecular dynamics simulations to investigate the interlayer nanopore trapping of two structurally-different fluoroquinolone (FQ) antimicrobials with similar acid-base chemistry: ciprofloxacin (a first-generation FQ) and moxifloxacin (a third-generation FQ)...
November 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29168978/excitations-in-the-quantum-liquid-4-he-a-review
#10
H R Glyde
Progress made in measuring and interpreting the elementary excitations of superfluid and normal liquid [Formula: see text] in the past 25 years is reviewed. The goal is to bring up to date the data, calculations and our understanding of the excitations since the books and reviews of the early 1990s. Only bulk liquid [Formula: see text] is considered. Reference to liquid [Formula: see text], mixtures, reduced dimensions (films and confined helium) is made where useful to enhance interpretation. The focus is on the excitations as measured by inelastic neutron scattering methods...
November 23, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/29168916/fabrication-characterization-and-biocompatibility-assessment-of-a-novel-elastomeric-nanofibrous-scaffold-a-potential-scaffold-for-soft-tissue-engineering
#11
Elham Shamirzaei Jeshvaghani, Laleh Ghasemi-Mobarakeh, Reza Mansurnezhad, Fatemeh Ajalloueian, Mahshid Kharaziha, Mohammad Dinari, Maryam Sami Jokandan, Ioannis S Chronakis
With regard to flexibility and strength properties requirements of soft biological tissue, elastomeric materials could be more beneficial in soft tissue engineering applications. The present work investigates the use of an elastic polymer, (polycaprolactone fumarate [PCLF]), for fabricating an electrospun scaffold. PCLF with number-average molecular weight of 13,284 g/mol was synthetized, electrospun PCLF:polycaprolactone (PCL) (70:30) nanofibrous scaffolds were fabricated and a novel strategy (in situ photo-crosslinking along with wet electrospinning) was applied for crosslinking of PCLF in the structure of PCLF:PCL nanofibers was presented...
November 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29168907/expanding-the-toolbox-of-photoswitches-for-dna-nanotechnology-using-arylazopyrazoles
#12
Adam Volker, Deepak Kumar Prusty, Mathias Centola, Škugor Marko, Hannam Jeffrey, Julián Valero, Klöckner Bernhard, Michael Famulok
Photoregulation is among the most promising tools for development of dynamic DNA nanosystems, due to its high spatiotemporal precision, biocompatibility, and ease of use. So far, azobenzene and its derivatives have shown high potential in photocontrolling DNA duplex hybridization due to light-dependent photoisomerization. Despite many recent advances, sufficiently high photoswitching efficiency under conditions more suitable for work with DNA nanostructures are challenging. Here we introduce a pair of arylazopyrazoles as new photoswitches for efficient and reversible control of DNA hybridization achieved even at room temperature with a low number of required modifications...
November 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29168877/full-angle-tomographic-phase-microscopy-of-flowing-quasi-spherical-cells
#13
Massimiliano M Villone, Pasquale Memmolo, Francesco Merola, Martina Mugnano, Lisa Miccio, Pier Luca Maffettone, Pietro Ferraro
We report a reliable full-angle tomographic phase microscopy (FA-TPM) method for flowing quasi-spherical cells along microfluidic channels. This method lies in a completely passive optical system, i.e. mechanical scanning or multi-direction probing of the sample is avoided. It exploits the engineered rolling of cells while they are flowing along a microfluidic channel. Here we demonstrate significant progress with respect to the state of the art of in-flow TPM by showing a general extension to cells having almost spherical shapes while they are flowing in suspension...
November 23, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29168864/using-time-resolved-photoelectron-spectroscopy-to-unravel-the-electronic-relaxation-dynamics-of-photoexcited-molecules
#14
Helen H Fielding, Graham A Worth
Time-resolved photoelectron spectroscopy measurements combined with quantum chemistry and dynamics calculations allow unprecedented insight into the electronic relaxation mechanisms of photoexcited molecules in the gas-phase. In this Tutorial Review, we explain the essential concepts linking photoelectron spectroscopy measurements with electronic structure and how key features on the potential energy landscape are identified using quantum chemistry and quantum dynamics calculations. We illustrate how time-resolved photoelectron spectroscopy and theory work together using examples ranging in complexity from the prototypical organic molecule benzene to a pyrrole dimer bound by a weak N-Hπ interaction and the green fluorescent protein chromophore...
November 23, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29168793/synthesis-analysis-cholinesterase-inhibiting-activity-and-molecular-modelling-studies-of-3-dialkylamino-2-hydroxypropyl-4-alkoxy-carbonyl-amino-benzoates-and-their-quaternary-ammonium-salts
#15
Tereza Padrtova, Pavlina Marvanova, Klara Odehnalova, Renata Kubinova, Oscar Parravicini, Adriana Garro, Ricardo D Enriz, Otakar Humpa, Michal Oravec, Petr Mokry
Tertiary amines 3-(dialkylamino)-2-hydroxypropyl 4-[(alkoxycarbonyl)amino]benzoates and their quaternary ammonium salts were synthesized. The final step of synthesis of quaternary ammonium salts was carried out by microwave-assisted synthesis. Software-calculated data provided the background needed to compare fifteen new resulting compounds by their physicochemical properties. The acid dissociation constant (pKa) and lipophilicity index (log P) of tertiary amines were determined; while quaternary ammonium salts were characterized by software-calculated lipophilicity index and surface tension...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29168748/variety-and-dynamics-of-proteoforms-in-the-human-proteome-aspects-of-markers-for-hepatocellular-carcinoma
#16
Stanislav Naryzhny, Victor Zgoda, Artur Kopylov, Elena Petrenko, Olga Kleist, Аlexander Archakov
We have previously developed an approach, where two-dimensional gel electrophoresis (2DE) was used, followed by sectional analysis of the whole gel using high-resolution nano-liquid chromatography-mass spectrometry (ESI LC-MS/MS). In this study, we applied this approach on the panoramic analysis of proteins and their proteoforms from normal (liver) and cancer (HepG2) cells. This allowed us to detect, in a single proteome, about 20,000 proteoforms coded by more than 4000 genes. A set of 3D-graphs showing distribution of these proteoforms in 2DE maps (profiles) was generated...
November 23, 2017: Proteomes
https://www.readbyqxmd.com/read/29168739/early-or-late-feeding-after-icu-admission
#17
REVIEW
Annika Reintam Blaser, Mette M Berger
The feeding of critically ill patients has recently become a controversial issue, as several studies have provided unexpected and contradictory results. Earlier beliefs regarding energy requirements in critical illness-especially during the initial phase-have been challenged. In the current review, we summarize existing evidence about fasting and the impact of early vs. late feeding on the sick organism's responses. The most important points are the non-nutritional advantages of using the intestine, and recognition that early endogenous energy production as an important player in the response must be integrated in the nutrient prescription...
November 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29168726/nutrient-modeling-for-a-semi-intensive-imc-pond-an-ms-excel-approach
#18
Lala I P Ray, B C Mal, S Moulick
Semi-intensive Indian Major Carp (IMC) culture was practised in polythene lined dugout ponds at the Aquacultural Farm of Indian Institute of Technology, Kharagpur, West Bengal for 3 consecutive years at three different stocking densities (S.D), viz., 20,000, 35,000 and 50,000 numbers of fingerlings per hectare of water spread area. Fingerlings of Catla, Rohu and Mrigal were raised at a stocking ratio of 4:3:3. Total ammonia nitrogen (TAN) value along with other fishpond water quality parameters was monitored at 1 day intervals to ensure a good water ecosystem for a better fish growth...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29168661/spatio-temporal-dynamics-of-cerebral-capillary-segments-with-stalling-red-blood-cells
#19
Şefik Evren Erdener, Jianbo Tang, Amir Sajjadi, Kıvılcım Kılıç, Sreekanth Kura, Chris B Schaffer, David A Boas
Optical coherence tomography (OCT) allows label-free imaging of red blood cell (RBC) flux within capillaries with high spatio-temporal resolution. In this study, we utilized time-series OCT-angiography to demonstrate interruptions in capillary RBC flux in mouse brain in vivo. We noticed ∼7.5% of ∼200 capillaries had at least one stall in awake mice with chronic windows during a 9-min recording. At any instant, ∼0.45% of capillaries were stalled. Average stall duration was ∼15 s but could last over 1 min...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29168638/homology-modeling-and-molecular-dynamics-simulation-combined-with-x-ray-solution-scattering-defining-protein-structures-of-thromboxane-and-prostacyclin-synthases
#20
Hsiao-Ching Yang, Cheng-Han Yang, Ming Yi Huang, Jyh-Feng Lu, Jinn-Shyan Wang, Yi-Qi Yeh, U-Ser Jeng
A combination of molecular dynamics (MD) simulations and X-ray scattering (SAXS) has emerged as the approach of choice for studying protein structures and dynamics in solution. This approach has potential applications for membrane proteins that neither are soluble nor form crystals easily. We explore the water-coupled dynamic structures of thromboxane synthase (TXAS) and prostacyclin synthase (PGIS) from scanning HPLC-SAXS measurements combined with MD ensemble analyses. Both proteins are heme-containing enzymes in the cytochrome P450 family, known as prostaglandin H2 (PGH2) isomerase, with counter functions in regulation of platelet aggregation...
November 23, 2017: Journal of Physical Chemistry. B
keyword
keyword
103148
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"