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https://www.readbyqxmd.com/read/28344477/development-and-characterization-of-methoxy-poly-ethylene-oxide-block-poly-%C3%AE%C2%B5-caprolactone-peo-b-pcl-micelles-as-vehicles-for-the-solubilization-and-delivery-of-tacrolimus
#1
Raisuddin Ali, Abubakar Farah, Ziyad Binkhathlan
Tacrolimus is a potent immunosuppressant; however, it suffers from several problems such as poor water solubility (4-12 μg/mL), low and variable oral bioavailability in patients, and narrow therapeutic window that could not be solved by the currently available i.v. formulation (Prograf®). Moreover, Prograf® contains HCO-60 (PEGylated castor oil) as a surfactant, which is reported to cause several side effects including hypersensitivity reactions. Therefore, the aim of the present study was to investigate the potential of PEO-b-PCL polymeric micelles as alternative vehicles for the solubilization and delivery of tacrolimus...
February 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28341843/multistructure-index-characterization-of-heart-rate-and-systolic-blood-pressure-reveals-precursory-signs-of-syncope
#2
Danuta Makowiec, Beata Graff, Zbigniew R Struzik
Recurrent syncope - abrupt loss of consciousness - can have a serious impact on patients' quality of life, comparable with chronic illnesses. Vasovagal syncope (VVS) is a specific reflex syncope, in which an inappropriate reaction of the autonomic nervous system (ANS) plays a key role in the pathophysiology. In syncope diagnosis, an ideal diagnostic method should positively identify vasovagal sensitive patients, without the need to perform a specialised head-up tilt table (HUTT) test. We apply a novel methodology of multistructure index (MI) statistics for seamlessly evaluating the size spectrum of the asymmetry properties of magnitudes of neural reflexes responsible for maintaining the homeostatic dynamics of autonomic control...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341333/h%C3%A2-control-for-a-class-of-singular-systems-with-state-time-varying-delay
#3
Shaohua Long, Shouming Zhong
This paper is concerned with the H∞ control problem for a class of singular systems. The systems under consideration involve state time-varying delay. The aim of this paper is to design a dynamic feedback controller such that the resultant closed-loop system is regular, impulse-free and stable with given H∞ performance index. By using the Lyapunov-Krasovskii functional method, some delay-dependent sufficient criteria which guarantee the existence of the dynamic feedback controller and determine explicitly the parameters of the dynamic feedback controller are presented...
January 2017: ISA Transactions
https://www.readbyqxmd.com/read/28340454/pea-cultivar-and-wheat-residues-affect-carbon-nitrogen-dynamics-in-pea-triticale-intercropping-a-microcosms-approach
#4
Antonella Scalise, Valentini A Pappa, Antonio Gelsomino, Robert M Rees
The underlying mechanisms by which legume cultivars contribute to nitrous oxide (N2O) generation are poorly understood. The aim of the present study was to explore the effects of two pea cultivars (Zero4 and Nitouche) intercropped with triticale, with or without wheat (Triticum aestivum) residues incorporation, on soil C and N dynamics, on bacterial community structure and their links with N2O emissions. Monocrops and bare soil (no plant) treatments were used as an additional control in order to account for the level of mineralisation between treatments...
March 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28339127/quantitative-ultrasound-texture-analysis-for-differentiating-preterm-from-term-fetal-lungs
#5
Sleiman R Ghorayeb, Luis A Bracero, Matthew J Blitz, Zara Rahman, Martin L Lesser
OBJECTIVES: To differentiate preterm (<37 weeks' gestation) from term (≥37 weeks' gestation) fetal lungs by using quantitative texture analysis of ultrasound images. METHODS: This study retrospectively evaluated singleton gestations with valid dating at 20 weeks' gestational age (GA) or later between January 2015 and December 2015. Images were obtained from Voluson E8 ultrasound systems (GE Healthcare, Milwaukee, WI). A region of interest was selected in each fetal lung image at the level of the 4 heart chambers from an area that appeared most representative of the overall lung tissue and had the least shadow...
March 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28339109/validation-of-dynamic-treatment-couch-tracking-for-prostate-sbrt
#6
Stefanie Ehrbar, Simon Schmid, Alexander Jöhl, Stephan Klöck, Matthias Guckenberger, Oliver Riesterer, Stephanie Tanadini-Lang
PURPOSE: In stereotactic body radiation therapy (SBRT) of prostatic cancer, a high dose per fraction is applied to the target with steep dose gradients. Intrafractional prostate motion can occur unpredictably during the treatment and lead to target miss. This work investigated the dosimetric benefit of motion compensation with dynamic treatment-couch tracking for prostate SBRT treatments in the presence of prostatic motion. METHODS: Ten SBRT treatment plans for prostate cancer patients with integrated boosts to their index lesion were prepared...
March 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28338964/relationship-between-fine-root-exudation-and-respiration-of-two-quercus-species-in-a-japanese-temperate-forest
#7
Lijuan Sun, Mioko Ataka, Yuji Kominami, Kenichi Yoshimura
Plants allocate a considerable amount of carbon (C) to fine roots as respiration and exudation. Fine-root exudation could stimulate microbial activity, which further contributes to soil heterotrophic respiration. Although both root respiration and exudation are important components of belowground C cycling, how they relate to each other is less well known. In this study, we aimed to explore this relationship on mature trees growing in the field. The measurements were performed on two canopy species, Quercus serrata Thunb...
March 17, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338637/using-an-active-optical-sensor-to-develop-an-optimal-ndvi-dynamic-model-for-high-yield-rice-production-yangtze-china
#8
Xiaojun Liu, Richard B Ferguson, Hengbiao Zheng, Qiang Cao, Yongchao Tian, Weixing Cao, Yan Zhu
The successful development of an optimal canopy vegetation index dynamic model for obtaining higher yield can offer a technical approach for real-time and nondestructive diagnosis of rice (Oryza sativa L) growth and nitrogen (N) nutrition status. In this study, multiple rice cultivars and N treatments of experimental plots were carried out to obtain: normalized difference vegetation index (NDVI), leaf area index (LAI), above-ground dry matter (DM), and grain yield (GY) data. The quantitative relationships between NDVI and these growth indices (e...
March 24, 2017: Sensors
https://www.readbyqxmd.com/read/28338582/validation-of-the-clinician-graded-electronic-facial-paralysis-assessment-the-eface
#9
Lauren Sh Chong, Timothy J Eviston, Tsu-Hui Hubert Low, Shaheen Hasmat, Susan E Coulson, Jonathan R Clark
BACKGROUND: Facial paralysis remains a debilitating condition despite advances in medical, surgical and adjunctive interventions. Established grading systems used to assess facial paralysis and interventional outcomes have well described limitations. The Electronic Facial Paralysis Assessment (the eFACE), a clinician-graded zone-based facial function scale, has recently emerged as a grading tool that may provide greater sensitivity when assessing incomplete paralysis and post-surgical improvement...
March 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28338573/a-machine-learning-based-surface-electromyography-topography-evaluation-for-prognostic-prediction-of-functional-restoration-rehabilitation-in-chronic-low-back-pain
#10
Naifu Jiang, Keith Dip-Kei Luk, Yong Hu
STUDY DESIGN: A retrospective study. OBJECTIVE: To investigate the feasibility and applicability of support vector machine (SVM) algorithm in classifying patients with LBP who would obtain satisfactory or unsatisfactory progress after the functional restoration rehabilitation program. SUMMARY OF BACKGROUND DATA: Dynamic surface electromyography (SEMG) topography has demonstrated the potential use in predicting the prognosis of functional restoration rehabilitation for patients with low back pain (LBP)...
March 23, 2017: Spine
https://www.readbyqxmd.com/read/28337706/clinical-and-radiological-outcomes-of-two-level-endoscopic-posterior-cervical-foraminotomy
#11
Myung Soo Youn, Myeong Hwan Shon, Yoon Jae Seong, Jong Ki Shin, Tae Sik Goh, Jung Sub Lee
PURPOSE: The efficacy and safety of endoscopic posterior cervical foraminotomy (EPCF) have been demonstrated for single-level cervical radiculopathy, but no report in the medical literature has described the clinical results of two-level EPCF. The aim of this study was to assess the clinical and radiological outcomes of two-level EPCF performed in patients with cervical radiculopathy. METHODS: Twenty-two consecutive patients (9 females and 13 males) that underwent two-level EPCF with cervical radiculopathy from January 2012 to January 2014 were included in this study...
March 23, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28336837/pnma-bn-another-boron-nitride-polymorph-with-interesting-physical-properties
#12
Zhenyang Ma, Zheng Han, Xuhong Liu, Xinhai Yu, Dayun Wang, Yi Tian
Structural, mechanical, electronic properties, and stability of boron nitride (BN) in Pnma structure were studied using first-principles calculations by Cambridge Serial Total Energy Package (CASTEP) plane-wave code, and the calculations were performed with the local density approximation and generalized gradient approximation in the form of Perdew-Burke-Ernzerhof. This BN, called Pnma-BN, contains four boron atoms and four nitrogen atoms buckled through sp³-hybridized bonds in an orthorhombic symmetry unit cell with Space group of Pnma...
December 28, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335569/a-quantitative-risk-assessment-model-involving-frequency-and-threat-degree-under-line-of-business-services-for-infrastructure-of-emerging-sensor-networks
#13
Xu Jing, Hanwen Hu, Huijun Yang, Man Ho Au, Shuqin Li, Naixue Xiong, Muhammad Imran, Athanasios V Vasilakos
The prospect of Line-of-Business Services (LoBSs) for infrastructure of Emerging Sensor Networks (ESNs) is exciting. Access control remains a top challenge in this scenario as the service provider's server contains a lot of valuable resources. LoBSs' users are very diverse as they may come from a wide range of locations with vastly different characteristics. Cost of joining could be low and in many cases, intruders are eligible users conducting malicious actions. As a result, user access should be adjusted dynamically...
March 21, 2017: Sensors
https://www.readbyqxmd.com/read/28334145/combined-effects-of-thinning-and-decline-on-fine-root-dynamics-in-a-quercus-robur-l-forest-adjoining-the-italian-pre-alps
#14
E Mosca, L Montecchio, G Barion, C Dal Cortivo, T Vamerali
Aims: Oak decline is a complex phenomenon, characterized by symptoms of canopy transparency, bark cracks and root biomass reduction. Root health status is one of the first stress indicators, and root turnover is a key process in plant adaptation to unfavourable conditions. In this study, the combined effects of decline and thinning were evaluated on fine root dynamics in an oak forest adjoining the Italian Pre-Alps by comparison of acute declining trees with non-declining trees, both with and without thinning treatment of surrounding trees...
February 28, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28333037/cerebral-hemodynamic-with-intra-aortic-balloon-pump-business-as-usual
#15
Juliana Caldas, Ronney B Panerai, Edson Bor-Seng-Shu, Juliano Almeida, Graziela Ferreira, Ligia Cunha, Ricardo Nogueira, Marcelo Oliveira, Fabio Jatene, Thompson Robinson, Ludhmila Hajjar
Intra-aortic balloon pump (IABP) is commonly used as mechanical support after cardiac surgery or cardiac shock. Although its benefits for cardiac function have been well documented, its effects on cerebral circulation are still controversial. We hypothesized that transfer function analysis (TFA) and continuous estimates of dynamic cerebral autoregulation (CA) provide consistent results in the assessment of cerebral autoregulation in patients with IABP. Continuous recordings of blood pressure (BP, intra-arterial line), end-tidal CO2, heart rate and cerebral blood flow velocity (CBFV, transcranial Doppler) were obtained i) 5 minutes with IABP ratio 1:3, ii) 5 minutes, starting 1 minute with the IABP-ON, and continuing for another 4 minutes without pump assistance (IABP-OFF)...
March 23, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28332629/plasmonic-metamaterial-for-electromagnetically-induced-transparency-analogue-and-ultra-high-figure-of-merit-sensor
#16
Dong Wu, Yumin Liu, Li Yu, Zhongyuan Yu, Lei Chen, Ruifang Li, Rui Ma, Chang Liu, Jinqiannan Zhang, Han Ye
In this work, using finite-difference time-domain method, we propose and numerically demonstrate a novel way to achieve electromagnetically induced transparency (EIT) phenomenon in the reflection spectrum by stacking two different types of coupling effect among different elements of the designed metamaterial. Compared with the conventional EIT-like analogues coming from only one type of coupling effect between bright and dark meta-atoms on the same plane, to our knowledge the novel approach is the first to realize the optically active and precise control of the wavelength position of EIT-like phenomenon using optical metamaterials...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332315/significant-increase-of-flow-kinetic-energy-in-nonresponders-patients-to-cardiac-resynchronization-therapy
#17
Sara Cimino, Dino Palombizio, Francesco Cicogna, Donatella Cantisani, Manuela Reali, Domenico Filomena, Valentina Petronilli, Carlo Iacoboni, Luciano Agati
BACKGROUNDS: It's still unclear if different patterns of intraventricular flow dynamics may be detected in patients nonresponders to cardiac resynchronization therapy (CRT) as compared to responders ones. Aim of this study was to evaluate the characteristics of left ventricular (LV) flow dynamics 6-months after CRT to identify Echo-particle imaging velocity (PIV) patterns were more frequently detected in nonresponders patients. METHODS: Thirty-two patients with dilated cardiomyopathy, undergoing CRT, were enrolled in this study...
March 23, 2017: Echocardiography
https://www.readbyqxmd.com/read/28331495/development-and-in-vitro-evaluation-of-liposomes-using-soy-lecithin-to-encapsulate-paclitaxel
#18
Thi Lan Nguyen, Thi Hiep Nguyen, Dai Hai Nguyen
The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131 ± 30.5 nm. Besides, PTX was efficiently encapsulated in Lips, 94...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28330175/exploration-of-the-binding-modes-of-l-asparaginase-complexed-with-its-amino-acid-substrates-by-molecular-docking-dynamics-and-simulation
#19
Erva Rajeswara Reddy, Rajulapati Satish Babu, Potla Durthi Chandrasai, Pola Madhuri
Acute lymphocytic leukemia (ALL) is an outrageous disease worldwide. L-Asparagine (L-Asn) and L-glutamine (L-Gln) deamination plays crucial role in ALL treatment. Role of Erwinaze(®) (L-asparaginase from Erwinia chrysanthemi) in regulation of L-Asn and L-Gln has been confirmed by the experimental studies. Therapeutic research against ALL remained elusive with the lack of structural information on Erwinaze(®) enzyme. In this present study, homology model of the Erwinaze(®) was developed using MODELLER and the same was validated by various quality indexing tools...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330107/population-dynamics-of-soil-bacteria-in-some-areas-of-midnapore-coastal-belt-west-bengal-india
#20
Syed Afrin Azmi, Soumendranath Chatterjee
In this present study the population dynamics of the soil bacteria of some coastal villages, namely Padima, Jatimati, Chanpabani, Palsandapur, Bhagibaharampur, Duttapur, Gangadharpur, Gobindabasan, Somaibasan of Digha, West Bengal, India, was determined. In these villages the aerobic heterotrophic, Gram-negative, spore-forming, starch-hydrolyzing, Pseudomonas, nitrate-reducing, denitrifying, asymbiotic N2 fixing, nitrifying, phosphate-solubilizing bacterial populations ranged from 1.22 to 2.67 × 10(6), 0...
June 2016: 3 Biotech
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