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https://www.readbyqxmd.com/read/29453817/endocrine-and-psychological-aspects-of-sexual-dysfunction-in-klinefelter-patients
#1
A Ferlin, R Selice, S Angelini, M Di Grazia, N Caretta, F Cavalieri, A Di Mambro, C Foresta
Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29453603/repeatable-and-reproducible-measurements-of-myocardial-oxidative-metabolism-blood-flow-and-external-efficiency-using-11-c-acetate-pet
#2
Kai Yi Wu, Vincent Dinculescu, Jennifer M Renaud, Shin-Yee Chen, Ian G Burwash, Lisa M Mielniczuk, Rob S B Beanlands, Robert A deKemp
BACKGROUND: Non-invasive approaches to investigate myocardial efficiency can help track the progression of heart failure (HF). This study evaluates the repeatability and reproducibility of 11 C-acetate positron emission tomography (PET) imaging of oxidative metabolism. METHODS AND RESULTS: Dynamic 11 C-acetate PET scans were performed at baseline and followup (47 ± 22 days apart) in 20 patients with stable HF with reduced ejection fraction. Two observers blinded to patients' clinical data used FlowQuant ® to evaluate test-retest repeatability, as well as intra- and inter-observer reproducibility of 11 C-acetate tracer uptake and clearance rates, for the measurement of myocardial oxygen consumption (MVO 2 ), myocardial external efficiency (MEE), work metabolic index (WMI), and myocardial blood flow...
February 16, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29452169/expression-patterns-of-toll-like-receptor-tlr-2-tlr-4-and-myeloid-differentiation-primary-response-gene-88-myd88-in-renal-transplant-patients-developing-allograft-dysfunction-a-cohort-study
#3
Morteza Hosseinzadeh, Pedram Ahmadpoor, Mir Saeed Yekaninejad, Fatemeh Pourrezagholi, Farshad Foroughi, Mina Ghorbanpour, Mehri Barabadi, Sanaz K Shahbaz, Ghasem Solgi, Aliakbar Amirzargar
This cohort intends to determine the sequential dynamic changes in Toll-like receptor (TLR)-4, TLR-2, and myeloid differentiation primary response gene 88 (MYD88) mRNA expressions in PBMCs and biopsy samples from kidney allograft recipients in relation to graft function. This study enrolled 52 renal transplant patients, 27 with well functioning graft (WFG) and 25 graft dysfunction (GD). Peripheral blood samples pre- and post-transplantation (days 2, 90 and 180) were collected to analyze mRNA expression levels of TLR-2, TLR-4, and MYD88 genes in relation to allograft function during one-year follow up...
February 13, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29451638/-association-between-health-anthropometric-indexes-with-physical-fitness-in-physically-active-elderly-women
#4
Pablo Valdés-Badilla, Andrés Godoy-Cumillaf, Jenny Ortega-Spuler, Tomás Herrera-Valenzuela, Samuel Durán-Agüero, José Zapata-Bastias, Rodrigo Vargas-Vitoria, Eduardo Guzmán-Muñoz, Antonio López-Fuenzalida
OBJECTIVE: To associate health anthropometric indexes with physical fitness of elderly women (EW) who participate in physical exercise workshops. MATERIALS AND METHODS: 272 Chilean women over 60 years took part in the study. The variables studied were BMI, waist circumference (WC), waist-height index (WHI) and physical fitness (PF). Correlations were made through the Pearson or Spearman coefficient, and bivariate associations using Pearson's Chi-square and the Fisher's exact test, considering p<0...
November 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29450627/can-the-use-of-a-single-integrated-unitary-autonomic-index-provide-early-clues-for-eventual-eligibility-for-olympic-games
#5
Daniela Lucini, Roberto Sala, Antonio Spataro, Mara Malacarne, Manuela Benzi, Stefano Tamorri, Massimo Pagani
PURPOSE: Optimal autonomic regulation and stress resilience might be considered critical elements of athletic performance. We hypothesize that a novel unitary autonomic index for sports (ANSIs), together with a somatic stress related symptom score (4SQ) might help characterize athletes who were eventually selected for the Rio 2016 Olympic Games Italian team (Rio +). METHODS: In this retrospective study we examined 778 athletes (age 24.4 ± 6.7 yrs) who underwent a planned yearly pre-participation screening...
February 15, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29449805/screen-position-preference-offers-a-new-direction-for-action-observation-research-preliminary-findings-using-tms
#6
Martin Riach, David J Wright, Zoë C Franklin, Paul S Holmes
Action observation has been suggested to be an effective adjunct to physical practice in motor (re)learning settings. However, optimal viewing conditions for interventions are yet to be established. Single-pulse transcranial magnetic stimulation (TMS) was used to investigate the effect of two different screen positions and participants' screen position viewing preference on the amplitude of motor evoked potentials (MEPs) during observation of a ball pinch action. Twenty-four participants observed four blocked conditions that contained either a dynamic index finger-thumb ball pinch or a static hand holding a ball in a similar position on a horizontally or vertically positioned screen...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29449144/a-dynamic-graph-cuts-method-with-integrated-multiple-feature-maps-for-segmenting-kidneys-in-2d-ultrasound-images
#7
Qiang Zheng, Steven Warner, Gregory Tasian, Yong Fan
RATIONALE AND OBJECTIVES: Automatic segmentation of kidneys in ultrasound (US) images remains a challenging task because of high speckle noise, low contrast, and large appearance variations of kidneys in US images. Because texture features may improve the US image segmentation performance, we propose a novel graph cuts method to segment kidney in US images by integrating image intensity information and texture feature maps. MATERIALS AND METHODS: We develop a new graph cuts-based method to segment kidney US images by integrating original image intensity information and texture feature maps extracted using Gabor filters...
February 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29448795/accelerated-sampling-by-infinite-swapping-of-path-integral-molecular-dynamics-with-surface-hopping
#8
Jianfeng Lu, Zhennan Zhou
To accelerate the thermal equilibrium sampling of multi-level quantum systems, the infinite swapping limit of a recently proposed multi-level ring polymer representation is investigated. In the infinite swapping limit, the ring polymer evolves according to an averaged Hamiltonian with respect to all possible surface index configurations of the ring polymer and thus connects the surface hopping approach to the mean-field path-integral molecular dynamics. A multiscale integrator for the infinite swapping limit is also proposed to enable efficient sampling based on the limiting dynamics...
February 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29448339/cooperative-behavior-of-molecular-motions-giving-rise-to-two-glass-transitions-in-the-same-supercooled-mesophase-of-a-smectogenic-liquid-crystal-dimer
#9
David O López, Josep Salud, María Rosario de la Fuente, Nerea Sebastián, Sergio Diez-Berart
In the present work, a detailed analysis of the glassy behavior and the relaxation dynamics of the liquid crystal dimer α-(4-cyanobiphenyl-4'-yloxy)-ω-(1-pyrenimine-benzylidene-4'-oxy) heptane (CBO7O.Py) throughout both nematic and smectic-A mesophases by means of broadband dielectric spectroscopy has been performed. CBO7O.Py shows three different dielectric relaxation modes and two glass transition (T_{g}) temperatures: The higher T_{g} is due to the freezing of the molecular motions responsible for the relaxation mode with the lowest frequency (μ_{1L}); the lower T_{g} is due to the motions responsible for the two relaxation modes with highest frequencies (μ_{1H} and μ_{2}), which converge just at their corresponding T_{g}...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29448331/fractional-dynamics-using-an-ensemble-of-classical-trajectories
#10
Zhaopeng Sun, Hao Dong, Yujun Zheng
A trajectory-based formulation for fractional dynamics is presented and the trajectories are generated deterministically. In this theoretical framework, we derive a new class of estimators in terms of confluent hypergeometric function (_{1}F_{1}) to represent the Riesz fractional derivative. Using this method, the simulation of free and confined Lévy flight are in excellent agreement with the exact numerical and analytical results. In addition, the barrier crossing in a bistable potential driven by Lévy noise of index α is investigated...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447043/re-engineering-the-interpretation-of-electronic-fetal-monitoring-to-identify-reversible-risk-for-cerebral-palsy-a-case-control-series
#11
Mark I Evans, Robert D Eden, David W Britt, Shara M Evans, Barry S Schifrin
BACKGROUND: Even Key Opinion leaders now concede that electronic fetal monitoring (EFM) cannot reliably identify fetal acidemia which many vouch as the only labor mediated pathophysiologic precursor for cerebral palsy (CP). We have developed the "Fetal Reserve Index" - an algorithm combining five dynamic components of EFM (1. Rate, 2. Variability, 3. Accelerations, 4. Decelerations, and 5. Excessive uterine activity) considered individually that are combined with the presence of: 6...
February 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29446759/photoelastic-colloidal-gel-for-high-sensitive-strain-sensor
#12
Hui Pan, Zhixin Chen, Shenmin Zhu, Chun Jiang, Di Zhang
Nanoparticles having the ability to self-assemble into order structure in their suspensions analogous to liquid crystals, have attracted extensive attention. Herein, we report a new type of colloidal gel with ordered crystal structure assembled from 1D and 2D nanoparticles. The materials has high elasticity, and more interestingly it shows significant photoelasticity. Its refractive index can be tuned under external stress and exhibits an ultra-wide dynamic range (Δ&lt;i&gt;n&lt;/i&gt;), in the order of 10&lt;sup&gt;-2&lt;/sup&gt;...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29446712/measures-of-sympathetic-and-parasympathetic-autonomic-outflow-from-heartbeat-dynamics
#13
Gaetano Valenza, Luca Citi, J Phillip Saul, Riccardo Barbieri
Reliable and effective non-invasive measures of sympathetic and parasympathetic peripheral outflow are of crucial importance in cardiovascular physiology. Although many techniques have been proposed to take up this long-lasting challenge, none has proposed a satisfying discrimination of the dynamics of the two separate branches. Spectral analysis of heart rate variability is the most currently used technique for such assessment. Despite its widespread use, it has been demonstrated that the subdivision in the low frequency (LF) and high frequency (HF) bands does not fully reflect separate influences of the sympathetic and parasympathetic branches, respectively, mainly due to their simultaneous action in the LF...
February 15, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29445933/multimodality-imaging-of-subacromial-impingement-syndrome
#14
REVIEW
Lionel Pesquer, Sophie Borghol, Philippe Meyer, Mickael Ropars, Benjamin Dallaudière, Pierre Abadie
Subacromial impingement syndrome results from irritation of the tendons of the rotator cuff muscles in the subacromial space and may manifest as a range of pathologies. However, subacromial impingement is a dynamic condition for which imaging reveals predisposing factors but no pathognomonic indicators. Also, the usual imaging features of subacromial impingement may be seen in symptomatic and asymptomatic patients. Therefore, imaging is able to detect tears and describe the risk factors of impingement but cannot confirm subacromial impingement...
February 14, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29445360/the-dynamic-distribution-of-small-tail-han-sheep-microbiota-across-different-intestinal-segments
#15
Hao Zhang, Mingxu Shao, He Huang, Shujuan Wang, Lili Ma, Huining Wang, Liping Hu, Kai Wei, Ruiliang Zhu
The sheep intestinal tract is characterized by a diverse microbial ecosystem that is vital for the host to digest diet material. The importance of gut microbiota (GM) of animals has also been widely acknowledged because of its pivotal roles in the health and well-being of animals. However, there are no relevant studies on GM of small-tail Han sheep, a superior mutton variety domestic in China. In this study, the structure and distribution of gut microflora were studied by high-throughput sequencing technology...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29444187/a-real-time-monitoring-platform-of-myogenesis-regulators-using-double-fluorescent-labeling
#16
Etai Sapoznik, Guoguang Niu, Yu Zhou, Peter M Prim, Tracy L Criswell, Shay Soker
Real-time, quantitative measurement of muscle progenitor cell (myoblast) differentiation is an important tool for skeletal muscle research and identification of drugs that support skeletal muscle regeneration. While most quantitative tools rely on sacrificial approach, we developed a double fluorescent tagging approach, which allows for dynamic monitoring of myoblast differentiation through assessment of fusion index and nuclei count. Fluorescent tagging of both the cell cytoplasm and nucleus enables monitoring of cell fusion and the formation of new myotube fibers, similar to immunostaining results...
2018: PloS One
https://www.readbyqxmd.com/read/29440620/quantification-of-hepatic-perfusion-and-hepatocyte-function-with-dynamic-gadoxetic-acid-enhanced-mr-imaging-in-patients-with-chronic-liver-disease
#17
Benjamin Leporq, Jean-Luc Daire, Catherine M Pastor, Pierre Deltenre, Christine Sempoux, Sabine Schmidt, Bernard E Van Beers
The purpose of this study was to develop and perform initial validation of dynamic MR imaging enhanced with gadoxetic acid as hepatobiliary contrast agent to quantify hepatic perfusion and hepatocyte function in patients with chronic liver disease. Free-breathing, dynamic gadoxetic acid-enhanced MR imaging was performed at 3.0 T using a three-dimensional time-resolved angiography sequence with stochastic trajectories during 38 minutes. A dual-input three-compartment model was developed to derive hepatic perfusion and hepatocyte function parameters...
February 12, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29435902/pediatric-living-donor-liver-transplantation-using-a-monosegment-procured-by-pure-3d-laparoscopic-left-lateral-sectionectomy-and-in-situ-reduction
#18
Suk Kyun Hong, Kyung-Suk Suh, Hyo-Sin Kim, Kyung Chul Yoon, Sung-Woo Ahn, Hyeyoung Kim, Nam-Joon Yi, Kwang-Woong Lee
BACKGROUND: Improvements in laparoscopic imaging systems and instruments have increased the performance of pure laparoscopic living donor hepatectomy. This operation is no longer limited to left lateral sectionectomy but is used for left hepatectomy and right hepatectomy.1-5 This report describes a donor who underwent pure laparoscopic left lateral sectionectomy and in situ reduction using 3D laparoscopy and indocyanine green (ICG) near-infrared fluorescence cholangiography to obtain a monosegment...
February 12, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29435641/wave-intensity-as-a-useful-modality-for-assessing-ventilation-perfusion-imbalance-in-subclinical-patients-with-hypertension
#19
Yoshie Nogami, Yoshihiro Seo, Masayoshi Yamamoto, Tomoko Ishizu, Kazutaka Aonuma
Wave intensity (WI) is a novel noninvasive index of circulatory dynamics that reflects ventriculo-arterial coupling. It is calculated as the product of the first derivative of blood pressure and that of flow velocity measured by carotid echocardiography. This study aimed to clarify the clinical implications of WI and its relation with carbon dioxide production (VE/VCO 2 slope). Twenty-one healthy volunteers (control group) and 21 patients with hypertension (HT group) underwent cardiopulmonary exercise testing (CPX) and exercise stress echocardiography...
February 12, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29434574/basal-and-dynamic-leptin-secretion-association-with-cardiometabolic-risk-and-body-weight-trajectories-in-african-americans-and-european-americans
#20
Sotonte Ebenibo, Chimaroke Edeoga, Ibiye Owei, Sam Dagogo-Jack
Background: Fasting plasma leptin levels reflect fat mass, but dynamic leptin responses to secretagogues, and the influence of race/ethnicity, have not been well studied. Here, we compared basal and stimulated leptin levels in relation to cardiometabolic risk and weight trajectories in black and white subjects. Subjects and methods: We studied 254 (127 black and 127 white) normoglycemic adults enrolled in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study...
2018: Frontiers in Endocrinology
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