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Glaucoma AND IOP

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https://www.readbyqxmd.com/read/28445203/considerations-for-refractive-surgery-in-the-glaucoma-patient
#1
Meleha Ahmad, Isaac Chocron, Anurag Shrivastava
PURPOSE OF REVIEW: Given the popularity of keratorefractive surgery, and an aging populous of patients who have undergone these procedures, there is an increasing need for updated management protocols. This is particularly relevant for patients with chronic progressive diseases such as glaucoma, due to the variety of related diagnostic and management challenges inherent to these diseases. Here, we will review the current literature to provide an update on the management of patients with glaucoma who are undergoing, or have had laser ablative refractive surgery...
April 25, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28442685/deep-sclerectomy
#2
Sylvain Roy, André Mermoud
Filtering surgery evolved from the classic trabeculectomy, in which penetration into the anterior chamber is a necessary step, toward nonpenetrating deep sclerectomy. The first procedure presents several serious complications, such as durable hypotony, hyphema, flat anterior chamber, choroidal detachment, endophthalmitis, and surgery-induced cataract. To avoid such drawbacks, a novel nonpenetrating technique was designed to improve the predictability of the intraocular pressure (IOP)-lowering action, while reducing the incidence of the immediate postoperative complications encountered with the penetrating method...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28442683/achievements-and-limits-of-current-medical-therapy-of-glaucoma
#3
Pelagia Kalouda, Christina Keskini, Eleftherios Anastasopoulos, Fotis Topouzis
Prescribing medical therapy for the treatment of glaucoma can be a complex process since many parameters should be taken into consideration regarding its achievements and limits. Today, a variety of options, including multiple drug classes and multiple agents within classes, are available to the clinician, but caution should be given to their side effects and contraindications. Glaucoma patients with preexisting ocular surface disease should be treated with caution, and preferably with preservative-free formulations, as there is an increased risk for symptom deterioration...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28441443/the-effect-of-parental-factors-in-children-with-large-cup-to-disc-ratios
#4
Hae-Young Lopilly Park, Min Ji Ha, Sun Young Shin
BACKGROUND: To investigate large cup-to-disc ratios (CDR) in children and to determine the relationship between parental CDR and clinical characteristics associated with glaucoma. METHODS: Two hundred thirty six children aged 6 to 12 years with CDR ≥ 0.6 were enrolled in this study. Subjects were classified into two groups based on parental CDR: disc suspect children with disc suspect (CDR ≥0.6) parents and disc suspect children without disc suspect parents...
2017: PloS One
https://www.readbyqxmd.com/read/28438591/effect-of-anesthesia-on-intraocular-pressure-measurement-in-children
#5
REVIEW
Mikel Mikhail, Kourosh Sabri, Alex V Levin
Measurement of the intraocular pressure (IOP) is central to the diagnosis and management of pediatric glaucoma. An examination under anesthesia is often necessary in pediatric patients. Different agents used for sedation or general anesthesia have varied effects on IOP. Hemodynamic factors, methods of airway management, tonometry technique, and body positioning can all affect IOP measurements. The most accurate technique is one that reflects the awake IOP. We review factors affecting IOP measurements in the pediatric population and provide recommendations on the most accurate means to measure IOP under anesthesia based on the current literature...
April 21, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28435237/evaluation-of-ex-press-glaucoma-implant-in-elderly-diabetic-patients-after-23g-vitrectomy
#6
Anita Lyssek-Boroń, Adam Wylęgała, Dariusz Dobrowolski, Ewelina Kowalczyk, Katarzyna Polanowska, Edward Wylęgała
PURPOSE: The most frequent qualifications for pars plana vitrectomy (PPV) in diabetic patients include recurrent hemorrhage into the vitreous body chamber and vitreoretinal proliferation, also with traction retinal detachment. The aim of this study was to evaluate the effectiveness of EX-PRESS implant for the treatment of secondary glaucoma in elderly diabetic patients following PPV 23G with silicon oil or SF6 gas endotamponade. MATERIALS AND METHODS: This retrospective analysis comprised 18 patients (19 eyes)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28435208/is-high-myopia-a-risk-factor-for-visual-field-progression-or-disk-hemorrhage-in-primary-open-angle-glaucoma
#7
Koji Nitta, Kazuhisa Sugiyama, Ryotaro Wajima, Gaku Tachibana
PURPOSE: The purpose of this study was to clarify differences between highly myopic and non-myopic primary open-angle glaucoma (POAG) patients, including normal-tension glaucoma patients. PATIENTS AND METHODS: A total of 269 POAG patients were divided into two groups: patients with ≥26.5 mm of axial length (highly myopic group) and patients with <24.0 mm of axial length (non-myopic group). RESULTS: We analyzed 53 highly myopic and 93 non-myopic POAG patients...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28430332/relationship-between-corneal-biomechanical-properties-and-optic-nerve-head-changes-after-deep-sclerectomy
#8
Laura Díez-Álvarez, Francisco J Muñoz-Negrete, Pilar Casas-Llera, Noelia Oblanca, Victoria de Juan, Gema Rebolleda
PURPOSE: To evaluate corneal biomechanical properties and optic nerve head (ONH) changes following deep sclerectomy (DS) and the relation to each other. METHODS: Forty-nine eyes with primary open-angle glaucoma that underwent DS were studied. Corneal biomechanical properties were assessed using the Ocular Response Analyzer and the ONH was evaluated by Spectralis optical coherence tomography with enhanced depth imaging technology before surgery and 3 months postoperatively...
April 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28430329/ahmed-valves-vs-trabeculectomy-combined-with-pans-plana-vitrectomy-for-neovascular-glaucoma-with-vitreous-hemorrhage
#9
Menghua H Wang, Qiuming M Li, Hongtao T Dong, Shuqian Q Dong, Yang Li, Chunyan Y Zheng
PURPOSE: Vitreous hemorrhage is common in advanced neovascular glaucoma (NVG), which has poor visual prognosis. This study aimed to compare the efficacy of 23-G pars planar vitrectomy (PPV) combined with either Ahmed glaucoma valve (AGV) implantation or trabeculectomy after intravitreal ranibizumab (IVR) treatment for NVG with vitreous hemorrhage. METHODS: This retrospective, nonrandomized study included 33 eyes of 33 patients with NVG with vitreous hemorrhage. After IVR treatment for 3-7 days, 18 eyes underwent PPV + AGV (AGV group) and 15 underwent PPV + trabeculectomy (trabeculectomy group)...
April 14, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28429294/ocular-cubosome-drug-delivery-system-for-timolol-maleate-preparation-characterization-cytotoxicity-ex-vivo-and-in-vivo-evaluation
#10
Jiayuan Huang, Tingting Peng, Yanrong Li, Zhengwen Zhan, Youmei Zeng, Ying Huang, Xin Pan, Chuan-Yu Wu, Chuanbin Wu
Glaucoma is an ocular disease featuring increased intraocular pressure (IOP) and its primary treatment strategy is to lower IOP by medication. Current ocular drug delivery in treating glaucoma is confronting a variety of challenges, such as low corneal permeability and bioavailability due to the unique anatomical structure of the human eye. To tackle these challenges, a cubosome drug delivery system for glaucoma treatment was constructed for timolol maleate (TM) in this study. The TM cubosomes (liquid crystalline nanoparticles) were prepared using glycerol monooleate and poloxamer 407 via high-pressure homogenization...
April 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28427069/practical-lessons-from-protocol-i-for-the-management-of-diabetic-macular-edema
#11
Lekha Mukkamala, Neelakshi Bhagat, Marco A Zarbin
Protocol I, a multicenter randomized clinical trial, compared the visual outcomes of patients treated with 0.5 mg intravitreal ranibizumab with either prompt or deferred (by 24 weeks laser), 4 mg intravitreal triamcinolone with prompt laser, or sham injection with prompt laser for the treatment of center-involving diabetic macular edema (DME). A total of 854 adult patients with type I or II diabetes and any level of non-proliferative diabetic retinopathy or proliferative retinopathy with adequate panretinal photocoagulation, with best-corrected visual acuity (BCVA) of 78 to 24 ETDRS letters (Snellen equivalent of 20/32 to 20/320) and visual loss attributed to macular edema, or retinal thickening with central subfield thickness of at least 250 µm by OCT were enrolled...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28426277/topical-ganciclovir-in-cytomegalovirus-anterior-uveitis
#12
Joelle Antoun, François Willermain, Dorine Makhoul, Elie Motulsky, Laure Caspers, Lia Judice Relvas
PURPOSE: To study the effects of topical ganciclovir 0.15% gel on cytomegalovirus (CMV) anterior uveitis in a tertiary uveitis referral center in Brussels, Belgium. METHODS: A retrospective study of patients with a clinical diagnosis of CMV anterior uveitis/endotheliitis demonstrated by a positive polymerase chain reaction and/or Goldmann-Witmer coefficient (GWc). RESULTS: We report a series of 15 patients presenting clinical characteristics of CMV anterior uveitis...
April 20, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28425986/p16ink4a-upregulation-mediated-by-tbk1-induces-retinal-ganglion-cell-senescence-in-ischemic-injury
#13
L U Li, Yin Zhao, Hong Zhang
Glaucoma is a leading cause of irreversible blindness worldwide that is characterized by progressive retinal ganglion cell (RGC) death. However, RGC senescence as a phase before RGC death, and the mechanism of RGC senescence remains unclear. Here, we demonstrate that TANK-binding protein 1 (TBK1) is upregulated in acute IOP elevation-induced ischemic retinas mouse model. Moreover, pre-treatment with the TBK1 inhibitor BX-795 reduced p16INK4a (p16) expression and RGC senescence. Upregulation of TBK1 via plasmid transfection increased Akt phosphorylation at Ser473 and Bmi1 phosphorylation...
April 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28424493/regulation-of-intraocular-pressure-by-microrna-cluster-mir-143-145
#14
Xinyu Li, Fangkun Zhao, Mei Xin, Guorong Li, Coralia Luna, Guigang Li, Qinbo Zhou, Yuguang He, Bo Yu, Eric Olson, Pedro Gonzalez, Shusheng Wang
Glaucoma is a major cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP), which causes optic nerve damage and retinal ganglion cell death, is the primary risk factor for blindness in glaucoma patients. IOP is controlled by the balance between aqueous humor secretion from the ciliary body (CB) and its drainage through the trabecular meshwork (TM). How microRNAs (miRs) regulate IOP and glaucoma in vivo is largely unknown. Here we show that miR-143 and miR-145 expression is enriched in the smooth muscle and trabecular meshwork in the eye...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421664/intermediate-and-long-term-outcome-of-piggyback-drainage-connecting-glaucoma-drainage-device-to-a-device-in-situ-for-improved-intraocular-pressure-control
#15
Edward Dervan, Edward Lee, Antonio Giubilato, Tina Khanam, Panayiotis Maghsoudlou, William H Morgan
IMPORTANCE: This study provides results of a treatment option for patients with failed primary glaucoma drainage device BACKGROUND: To describe and evaluate the long term intraocular pressure (IOP) control and complications of a new technique joining a second glaucoma drainage device (GDD) directly to an existing GDD: termed "piggyback drainage". DESIGN: A retrospective, interventional cohort study PARTICIPANTS: 18 eyes of 17 patients who underwent piggyback drainage between 2004 and 2013 inclusive...
April 19, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28416927/cataract-surgery-and-possible-complications-in-patients-with-pseudoexfoliation-syndrome
#16
Gulsum Egemen Erkayhan, Semih Dogan
OBJECTIVE: The aim of this study was to evaluate the demographic characteristics and intraoperative complications of cataract surgery in patients with pseudoexfoliation syndrome (PEX). MATERIALS AND METHODS: Cases of 225 eyes (80 eyes with pseudoexfoliation and 145 eyes without pseudoexfoliation as the control group) that underwent phacoemulsification cataract surgery and IOL implantation at the Silifke State Hospital Ophthalmology Clinic between April 2011 and April 2013 were analysed retrospectively...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28416494/long-term-clinical-course-of-normotensive-preperimetric-glaucoma
#17
Akira Sawada, Yusuke Manabe, Tetsuya Yamamoto, Chisato Nagata
AIMS: To evaluate the long-term clinical course of normotensive preperimetric glaucoma (PPG). METHODS: We retrospectively analysed 130 eyes of 130 patients initially diagnosed as having preperimetric normal tension glaucoma and followed these cases for at least 5 years with reliable visual field (VF) examinations by standard automated perimetry. When the VF defect (VFD) met Anderson-Patella's criteria on three or more consecutive examinations, and consistently met the criteria on subsequent examinations, we concluded that a glaucomatous VFD was present...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28416493/phacoemulsification-compared-with-phacotrabeculectomy-surgery-a-within-person-observational-cohort-study
#18
Kazim Dhalla, Simon Cousens, Ian E Murdoch
AIM: To compare reduction in intraocular pressure (IOP) and gain in visual acuity (VA) following phacotrabeculectomy (PT) and phacoemulsification(phaco) in Tanzanian patients with primary open angle glaucoma(POAG). SETTING: CCBRT Hospital, Dar es Salaam, Tanzania. DESIGN: Within-person observational cohort study. METHODS: Within each patient, one eye had PT and the other phaco. Patients were followed for up to 5-1/2 years, and IOP and VA in each eye were assessed...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28414059/a-mouse-ocular-explant-model-that-enables-the-study-of-living-optic-nerve-head-events-after-acute-and-chronic-intraocular-pressure-elevation-focusing-on-retinal-ganglion-cell-axons-and-mitochondria
#19
Elizabeth C Kimball, Mary E Pease, Matthew R Steinhart, Ericka N Oglesby, Ian Pitha, Cathy Nguyen, Harry A Quigley
We developed an explant model of the mouse eye and optic nerve that facilitates the study of retinal ganglion cell axons and mitochondria in the living optic nerve head (ONH) in an ex vivo environment. Two transgenic mouse strains were used, one expressing yellow fluorescent protein in selected axons and a second strain expressing cyan fluorescent protein in all mitochondria. We viewed an explanted mouse eye and optic nerve by laser scanning microscopy at and behind the ONH, the site of glaucoma injury. Explants from previously untreated mice were studied with the intraocular pressure (IOP) set artificially at normal or elevated levels for several hours...
April 14, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28413868/goniosynechialysis-and-repositioning-of-intraocular-lens-in-a-case-of-secondary-angle-closure-glaucoma
#20
Masaru Fujita, Masafumi Ogata, Yasuyuki Suzuki, Tsunetomo Ichihashi, Miyuki Nagahara, Kenji Kawai
PURPOSE: Implanting intraocular lens (IOL) in proper direction is important in cataract surgery to reduce the possibility of undesirable complications. We experienced a case who underwent vitrectomy combined with cataract surgery and developed secondary angle closure glaucoma caused by IOL misdirection. Goniosynechialysis (GSL) and repositioning of IOL successfully ameliorated the high intraocular pressure (IOP). CASE REPORT: A 64-year-old male with massive vitreous hemorrhage underwent vitrectomy combined with cataract surgery...
April 20, 2017: Tokai Journal of Experimental and Clinical Medicine
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