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Glaucoma AND IOP

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https://www.readbyqxmd.com/read/29456251/tonometers-which-one-should-i-use
#1
REVIEW
Kanza Aziz, David S Friedman
Although several factors are known to play a role in the development and progression of glaucoma, intraocular pressure (IOP) remains the only modifiable risk factor. Medical and surgical treatments for glaucoma both aim to reduce IOP to minimize disease progression. Tonometry is therefore an essential element of the ophthalmological exam. There are several types of tonometers available currently. These range from well-established instruments that have been in clinical use for decades to new devices, which are the result of recent technological advances...
February 19, 2018: Eye
https://www.readbyqxmd.com/read/29453668/netarsudil-ophthalmic-solution-0-02-first-global-approval
#2
Sheridan M Hoy
Netarsudil ophthalmic solution 0.02% (hereafter referred to as netarsudil 0.02%) [Rhopressa ® ] is a Rho-associated protein kinase inhibitor that is thought to lower intraocular pressure (IOP) by increasing aqueous humour outflow through the trabecular meshwork. It has been developed by Aerie Pharmaceuticals and was recently approved in the USA for the reduction of elevated IOP in patients with open-angle glaucoma or ocular hypertension. The recommended dosage is one drop in the affected eye(s) once daily in the evening...
February 16, 2018: Drugs
https://www.readbyqxmd.com/read/29451146/safety-and-efficiency-of-trabectome-mediated-trabecular-meshwork-ablation-for-chinese-glaucoma-patients-a-two-year-retrospective-multicentre-study
#3
Ya-Long Dang, Yu-Jie Cen, Ying Hong, Ping Huang, Ning-Li Wang, Chao Wang, Chun Zhang
Background: The aim of the study was to evaluate the long-term safety and efficacy of the Trabectome for Chinese glaucoma patients. Methods: This was a multicenter, retrospective, observational study. Glaucoma patients, except those with neovascular glaucoma, with/without a visually significant cataract were enrolled. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation. The primary outcome evaluation was a reduction in intraocular pressure (IOP), and the secondary outcomes were a reduction in glaucoma medication, the 2-year success percentages, and complications...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29450400/incidence-of-ocular-hypertension-after-intravitreal-injection-of-anti-vegf-agents-in-the-treatment-of-neovascular-amd
#4
Andreea Moraru, Gabriela Pînzaru, Anca Moţoc, Dănuţ Costin, Daniel Brănişteanu
Purpose. The assessment of the incidence of ocular hypertension over a period of 1 year in patients treated with multiple intravitreal injections of anti-VEGF agents for neovascular AMD. Methods. The study comprised 58 eyes diagnosed with neovascular age-related macular degeneration and receiving PRN intravitreal treatment with anti-VEGF agents (bevacizumab or aflibercept). The follow-up period was 1 year. Intraocular pressure was measured by using the Goldmann applanation tonometry before the intravitreal injection, at 24 hours after the administration of the anti-VEGF agent and at 1 and 4 weeks...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450399/functional-results-of-cataract-surgery-in-the-treatment-of-phacomorphic-glaucoma
#5
Andreea Moraru, Gabriela Pînzaru, Anca Moţoc, Dănuţ Costin
Purpose. Analysis of functional outcome and complications reported in patients diagnosed with phacomorphic glaucoma, in which phacoemulsification or extracapsular extraction of the lens was performed. Methods. The retrospective study included 38 eyes diagnosed with phacomorphic glaucoma. In 25 cases, group 1, the lens was removed by phacoemulsification and in 13 cases, group 2, by extracapsular extraction. Intraocular pressure, visual acuity, and anterior chamber depth were evaluated preoperative and postoperative...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450398/cataract-surgery-outcome-in-patients-with-non-glaucomatous-pseudoexfoliation
#6
Praveen Venkatesha Sastry, Anuj Kumar Singal
Aim. To study the outcome of cataract surgery in eyes with pseudoexfoliation without signs of glaucoma. Methods. This prospective study was done over nine months on patients with pseudoexfoliation undergoing small incision cataract surgery. Only patients with normal intraocular pressure (Central Corneal Thickness Corrected), normal cup disc ratio and open angles were included. Patients on anti-glaucoma medication were excluded. Patients underwent surgery performed by a single senior surgeon. Intraoperative and postoperative day (POD) 1 findings were noted...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450392/glaucoma-after-penetrating-keratoplasty
#7
REVIEW
Mihail Zemba, Alina-Cristina Stamate
Penetrating keratoplasty is a surgical intervention that despite the progress of surgical techniques and of postoperative treatment continues to have numerous complications. Many of them, such as graft rejection, significant astigmatism, cystoid macular edema, or cataract lead to important limitations of the visual function. Glaucoma is possibly the most dangerous complication following PK, leading to loss of the visual potential of the eye due to irreversible damage to the optic nerve. Identifying the risk factors permits an attentive follow-up and rapid treatment of the postoperative IOP rises...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450384/plateau-iris-therapeutic-options-and-functional-results-after-treatment
#8
Crenguța Feraru, Andrei Bâlha, Victor Aursulesei, Andrei Filip, Anca Pantalon
We present the therapeutic options and functional results in patients with plateau iris (syndrome or configuration) in consecutive case series. Material and method: Our study included newly diagnosed patients with acute angle closure by "plateau iris" (configuration or syndrome), between June 2016 and April 2017. Series of 8 consecutive patients met the inclusion criteria, all being females. All the patients underwent an individualized treatment according to the underlying mechanism and evolution...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450382/iridex-micropulse-p3-innovative-cyclophotocoagulation
#9
M Monica Gavris, Ioana Olteanu, Erzsebet Kantor, Radu Mateescu, Roxana Belicioiu
Purpose: To present the new IRIDEX MicroPulse P3 (MP3) technology in patients with refractory glaucoma and our preliminary results at 1 week and 1 month postoperatively. Methods: IRIDEX MP3 laser cyclophotocoagulation was performed in 7 eyes of 7 patients under retrobulbar anaesthesia with lidocaine 2% in the operating room. Each eye received two treatments of 80-90s over the superior and inferior hemisphere, avoiding the temporal- and nasal-most clock hours. 810nm IRIDEX MP3 was set to 31,3% duty cycle (0,5ms treatment pulse followed by 1,1 ms of rest)...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29449654/analysis-combining-correlated-glaucoma-traits-identifies-five-new-risk-loci-for-open-angle-glaucoma
#10
Puya Gharahkhani, Kathryn P Burdon, Jessica N Cooke Bailey, Alex W Hewitt, Matthew H Law, Louis R Pasquale, Jae H Kang, Jonathan L Haines, Emmanuelle Souzeau, Tiger Zhou, Owen M Siggs, John Landers, Mona Awadalla, Shiwani Sharma, Richard A Mills, Bronwyn Ridge, David Lynn, Robert Casson, Stuart L Graham, Ivan Goldberg, Andrew White, Paul R Healey, John Grigg, Mitchell Lawlor, Paul Mitchell, Jonathan Ruddle, Michael Coote, Mark Walland, Stephen Best, Andrea Vincent, Jesse Gale, Graham RadfordSmith, David C Whiteman, Grant W Montgomery, Nicholas G Martin, David A Mackey, Janey L Wiggs, Stuart MacGregor, Jamie E Craig
Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the results with GWAS data for intraocular pressure (IOP) and optic disc parameters (the overall meta-analysis sample size varying between 32,000 to 48,000 participants), which are glaucoma-related traits. We identified and independently validated four novel genome-wide significant associations within or near MYOF and CYP26A1, LINC02052 and CRYGS, LMX1B, and LMO7 using single variant tests, one additional locus (C9) using gene-based tests, and two genetic pathways - "response to fluid shear stress" and "abnormal retina morphology" - in pathway-based tests...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445943/impact-of-the-clinical-use-of-rock-inhibitor-on-the-pathogenesis-and-treatment-of-glaucoma
#11
REVIEW
Megumi Honjo, Hidenobu Tanihara
Rho-associated protein kinase (ROCK), a ubiquitously expressed signaling messenger and downstream effector of Rho, is activated by several bioactive factors in the aqueous humor (AH). Rho-ROCK signaling regulates a wide spectrum of fundamental cellular events, including cell adhesion, motility, proliferation, differentiation, and apoptosis. Previous studies, including our own, found that ROCK inhibitor lowers intraocular pressure (IOP) via a direct effect on the conventional AH outflow pathway, by regulation of contractile properties, fibrotic activity, and permeability of the trabecular meshwork (TM) and Schlemm's canal (SC) tissues, influencing extracellular matrix (ECM) production...
February 14, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29444785/longitudinal-changes-in-intraocular-pressure-and-association-with-systemic-factors-and-refractive-error-lingtou-eye-cohort-study
#12
Xiaotong Han, Tangjian Yang, Jian Zhang, Sha Yu, Xinxing Guo, William Yan, Yin Hu, Mingguang He
OBJECTIVES: To investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population. DESIGN: Prospective cohort study. SETTING: Guangzhou Government Servant Physical Check-up Center, Guangzhou, China. PARTICIPANTS: 4413 government employees aged no less than 40 years (41.9% female) attending annual physical and eye examinations were included in this study...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29444665/comparison-of-1-year-outcomes-after-ahmed-glaucoma-valve-implantation-with-and-without-ologen-adjuvant
#13
Tai Jun Kim, Sohyun Kang, Jin Wook Jeoung, Young Kook Kim, Ki Ho Park
BACKGROUND: Many studies have investigated the clinical benefits of Ologen for trabeculectomy. However, its benefits for Ahmed glaucoma valve (AGV) implantation have not been investigated as extensively. The aim of this study was to compare the 1-year outcomes of AGV implantation with and without Ologen adjuvant for the treatment of refractory glaucoma. METHODS: This retrospective study included a total of 20 eyes of 20 glaucoma patients, who were followed for at least 1-year after undergoing AGV implantation...
February 14, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29443031/ultrasound-cyclo-plasty-in-eyes-with-glaucoma
#14
Giuseppe Giannaccare, Stefano Sebastiani, Emilio C Campos
Glaucoma is a chronic disease caused by the progressive degeneration of the optical nerve fibers, resulting in decreased visual field that can lead to severe visual impairment, and eventually blindness. This manuscript describes a simple, surgeon-friendly, non-incisional technique, named Ultrasound Cyclo Plasty (UCP), for reducing intraocular pressure (IOP) in glaucoma patients. The technique determines a selective coagulation necrosis of the ciliary body; in addition, the stimulation of supra-choroidal and trans-scleral portions of the uveo-scleral outflow pathway has been recently proposed...
January 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442246/cataract-surgery-in-patients-with-glaucoma-drainage-implants-the-hooked-tube-technique
#15
Juha Välimäki
PURPOSE: Cataract surgery has been reported to adversely affect the IOP control in eyes with the glaucoma drainage implant (GDI). One reason might be the flow of lens debris/viscoelastic material through the GDI tube into the bleb. This pilot study was conducted to determine the clinical results of a novel technique for temporary occlusion of the GDI tube with an iris retractor hook during phacoemulsification. METHODS: Retrospective analysis of 15 patients (control group) who underwent phacoemulsification between January 2005 and December 2010 and 17 patients (treatment group) who underwent phacoemulsification with the hooked tube technique between January 2011 and April 2016 with a minimum 1-year follow-up...
February 13, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29440870/surgical-outcomes-of-membrane-tube-type-glaucoma-shunt-device-in-indigenous-west-africans
#16
Olusola Olawoye, Tarela Sarimiye, Adeyinka Ashaye, Young Hoon Hwang, Jong Chul Han, Byung Heon Ahn
Purpose: The aim of this study was to report the safety and efficacy of the membrane-tube (MT)-type glaucoma shunt device (Finetube MT) in the management of refractory glaucoma in indigenous West Africans. Methods: The Finetube MT was implanted into 25 eyes of 25 West African patients with refractory glaucoma. These patients had inadequate intraocular pressure (IOP) control despite maximum tolerable IOP-lowering medications with or without previous ocular surgeries...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29440867/long-term-titrated-iop-control-with-one-two-or-three-trabecular-micro-bypass-stents-in-open-angle-glaucoma-subjects-on-topical-hypotensive-medication-42-month-outcomes
#17
L Jay Katz, Carl Erb, Amadeu Carceller Guillamet, Antonio M Fea, Lilit Voskanyan, Jane Ellen Giamporcaro, Dana M Hornbeak
Purpose: Evaluate long-term outcomes after one, two, or three trabecular micro-bypass stents implanted in a standalone procedure in eyes with open-angle glaucoma taking ocular hypotensive medication. Patients and methods: Prospective randomized ongoing study of 119 subjects (109 with 42-month follow-up) with open-angle glaucoma, preoperative intraocular pressure (IOP) 18-30 mmHg on one to three glaucoma medications, and unmedicated (post-washout) IOP 22-38 mmHg...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29440866/long-term-progression-of-visual-field-defects-and-related-factors-in-medically-treated-normal-tension-glaucoma
#18
Keiji Yoshikawa, Kazunori Santo, Hiroko Hizaki, Masayo Hashimoto
Purpose: To analyze factors related to long-term progression of visual field defects (VFD) in patients with normal tension glaucoma (NTG) under medical therapy. Patients and methods: Clinical data from 622 eyes of 311 primary open-angle glaucoma and NTG patients were collected from April 2006 to March 2016. Of these patients, those with normal intraocular pressure (IOP); glaucomatous VFD judged by Anderson's criteria; corrected visual acuity ≥0.7; receiving more than 6 years medical therapy; having undergone ≥10 visual field tests performed at 6-month intervals using a Humphrey field analyzer (Swedish Interactive Threshold Algorithms standard, C 24-2 program); and having reliability coefficients of visual field testing <33% and mean deviation (MD) more than -20 decibels in the initial visual field test were included in data analysis...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29440700/age-related-changes-in-the-response-of-retinal-structure-function-and-blood-flow-to-pressure-modification-in-rats
#19
Da Zhao, Christine T O Nguyen, Zheng He, Vickie H Y Wong, Anna K van Koeverden, Algis J Vingrys, Bang V Bui
Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the brain (intracranial pressure, ICP) can modify the risk of glaucoma. In this study, we consider whether the optic nerve in older rat eyes is more susceptible to acute IOP and ICP modification. We systematically manipulate both ICP and IOP and quantify their effects on ganglion cell function (electroretinography, ERG), optic nerve structure (optical coherence tomography, OCT) and retinal blood flow (Doppler OCT)...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440041/factors-predicting-the-success-of-trabeculectomy-bleb-enhancement-with-needling
#20
Jonathan Y-X L Than, Toby S Al-Mugheiry, Jesse Gale, Keith R Martin
BACKGROUND: Bleb needling is widely used to restore flow and lower intraocular pressure (IOP) in a failing trabeculectomy. We aimed to measure the safety and efficacy of needling in a large cohort and identify factors that were associated with success and failure. METHODS: This retrospective audit included all patients who underwent needling at Addenbrooke's Hospital, Cambridge over a 10-year period. Data were available on 91 patients (98% of patients identified), including 191 needlings on 96 eyes...
February 9, 2018: British Journal of Ophthalmology
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