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Glaucoma AND IOP

Wan-Hua Cho, Ing-Chou Lai, Po-Chiung Fang, Chun-Chih Chien, Shin-Ling Tseng, Yu-Hsuan Lai, Yu-Ting Huang, Ming-Tse Kuo
PURPOSE: To investigate the meibomian gland (MG) performance in patients with glaucoma under topical intraocular pressure (IOP)-lowering medications. METHODS: This was a cross-sectional case-control study. Patients with glaucoma under different dosages and instillation periods of topical IOP-lowering medications were included. A total of 30 eyes out of 30 healthy participants and 85 eyes out of 85 patients with glaucoma were analyzed. The burden of instilling anti-glaucoma agents (BAG) was simply scored for each participant based on the number, formula, frequency, and duration of topical IOP-lowering medications used...
December 13, 2017: Journal of Glaucoma
Pablo Romero, Pradtana Hirunpatravong, Reza Alizadeh, Eun-Ah Kim, Kouros Nouri-Mahdavi, Esteban Morales, Simon K Law, Joseph Caprioli
PURPOSE: There are no reported large series of trabeculectomy with mitomycin-C (MMC) in Western patients with primary angle-closure glaucoma (PACG). Our study evaluates long-term tonometric outcomes of trabeculectomy in PACG. METHODS: This is a retrospective cohort study. The primary outcomes were the Kaplan-Meier success rates on survival analyses using three criteria, with or without adjunctive medication: (A) intraocular pressure (IOP) ≤18▒mmHg and IOP reduction of 20%; (B) IOP≤15▒mmHg and IOP reduction 25%; and (C) IOP≤12▒mmHg and IOP reduction 30%...
December 13, 2017: Journal of Glaucoma
Reza Alizadeh, Handan Akil, James Tan, Simon K Law, Joseph Caprioli
PURPOSE: To evaluate outcomes of trabeculectomy with adjunctive Mitomycin-C (MMC) in patients with uncontrolled intraocular pressure (IOP) after glaucoma drainage device implantation (GDD). METHODS: Consecutive patients who had undergone a trabeculectomy after GDD were reviewed. The primary outcome was surgical success with stratified IOP targets based on the following criteria: (A) IOP <18▒mm Hg and IOP reduction of 20%; (B) IOP <15▒mm Hg and IOP reduction of 25%; (C) IOP <12▒mm Hg and IOP reduction of 30%...
December 12, 2017: Journal of Glaucoma
Masaki Tanito, Yukari Matsuzaki, Yoshifumi Ikeda, Etsuko Fujihara
Aim: To compare surgically induced astigmatism (SIA) among glaucomatous eyes treated with trabeculectomy (LEC), EX-PRESS® shunt (EXP), ab externo trabeculotomy (exLOT), or microhook ab interno trabeculotomy (μLOT). Subjects and methods: Eighty right eyes of 80 subjects who underwent LEC (n=20), EXP (n=20), exLOT (n=20), or μLOT (n=20) were included. The dataset including the best-corrected visual acuity (BCVA), intraocular pressure (IOP), and keratometry recordings preoperatively and 3 months postoperatively was collected by chart review...
2017: Clinical Ophthalmology
Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto, Toru Nakazawa
PURPOSE: There is no consensus on the diagnosis or treatment policy for Preperimetric Glaucoma (PPG) because the pathogenesis of PPG is not clear at this time. Preperimetric Glaucoma Prospective Observational Study (PPGPS) is a first multicenter, prospective, observational study to clarify the pathogenesis of PPG. This article indicates study design, patient baseline characteristics, and analysis focused on optic nerve head (ONH) blood flow in PPG, as well as the intraocular pressure (IOP) -lowering effect and ONH blood flow-improving effects of Tafluprost...
2017: PloS One
Hélène Choquet, Khanh K Thai, Jie Yin, Thomas J Hoffmann, Mark N Kvale, Yambazi Banda, Catherine Schaefer, Neil Risch, K Saidas Nair, Ronald Melles, Eric Jorgenson
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability. Here, we conduct a genome-wide association study of IOP in 69,756 untreated individuals of European, Latino, Asian, and African ancestry. Multiple longitudinal IOP measurements were collected through electronic health records and, in total, 356,987 measurements were included...
December 13, 2017: Nature Communications
Karsten Sperlich, Stephan Reiß, Sebastian Bohn, Heinrich Stolz, Rudolf F Guthoff, Anselm Jünemann, Oliver Stachs
Elevated intraocular pressure (IOP) is accepted to be one important criterion for glaucoma and is usually measured by applanation or rebound tonometry. The individual uncertainty due to central cornea thickness (CCT) is thereby corrected, while the error induced by age-related elastic modulus (EM) change of the cornea is ignored. To investigate its influence on IOP measurement, we derive a model including also the elastic modulus. Our approach is based on known equations from experimental physics and several assumptions being justified in this paper...
December 2017: Klinische Monatsblätter Für Augenheilkunde
Janice J C Cheung, Kenneth K W Li, Samuela W K Tang
PURPOSE: Transscleral cyclodiode laser cyclophotocoagulation (TSCP) is often reserved for treatment of refractory glaucoma. This retrospective study investigates the safety and efficacy of TSCP among the Chinese population. METHODS: A retrospective review was performed on electronic patient records of all patients receiving TSCP between years 2009 to year 2016. Patient demographics, indication for laser, success and response rate, change in intraocular pressure (IOP), number of treatment sessions, laser energy, glaucoma medication, visual acuity, pain symptoms and complication rate were documented...
December 11, 2017: International Ophthalmology
Rohan K Barse, Amol A Tagalpallewar, Chandrakant R Kokare, Jaya P Sharma, Pankaj K Sharma
CONTEXT: Short residence time, poor bioavailability and poor permeability are the major problems for conventional eye drops treatment. OBJECTIVE: The aim of this article is to develop, optimize and ex vivo-in vivo investigation of brimonidine tartrate in situ gel as compare to marketed eye drops for the treatment of glaucoma. MATERIALS AND METHODS: The effect of independent variables viz. concentrations of polymers, on various dependent variables like viscosity at physiological pH and in vitro drug release were studied by using 32 factorial design...
December 12, 2017: Drug Development and Industrial Pharmacy
Sunny E Ohia, Jenaye Robinson, Leah Mitchell, Kalu K Ngele, Segewkal Heruye, Catherine A Opere, Ya Fatou Njie-Mbye
Hydrogen sulfide (H2S) is a gaseous transmitter with well-known biological actions in a wide variety of tissues and organs. The potential involvement of this gas in physiological and pathological processes in the eye has led to several in vitro, ex vivo, and in vivo studies to understand its pharmacological role in some mammalian species. Evidence from literature demonstrates that 4 enzymes responsible for the biosynthesis of this gas (cystathionine β-synthase, CBS; cystathionine γ-lyase, CSE; 3-mercaptopyruvate sulfurtransferase, 3MST; and d-amino acid oxidase) are present in the cornea, iris, ciliary body, lens, and retina...
December 7, 2017: Journal of Ocular Pharmacology and Therapeutics
M A Özer, Z Erişgin, S Özen, Y Tekelioğlu, S Takır
We investigated the possible neuroprotectant and intraocular pressure (IOP) lowering effects of intravitreous injection of sodium hydrosulfide (NaSH) in a rodent model of experimental glaucoma. Glaucoma currently is treated by controlling IOP using medications and/or surgery. These methods are not entirely adequate for all patients. We divided 24 rats into three groups. For the control group, the right eye was treated with intravitreous saline. For the glaucoma group, ocular hypertension was induced by photocoagulating three episcleral veins and the limbal plexus of the right eye using an argon laser, then saline was injected into the vitreous of these eyes during the third week...
December 7, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Pik Fang Kho, Rodney A Lea, Miles C Benton, David Eccles, Larisa M Haupt, Alex W Hewitt, Justin C Sherwin, David A Mackey, Lyn R Griffiths
Primary open-angle glaucoma (POAG) is influenced by both genetic and environmental factors. Despite significant progress in identifying genetic variants associated with POAG, there remains a substantial amount of unexplained heritability. Study design features that may enhance knowledge of the genetic architecture include focusing on multiple quantitative traits related to ocular disorders (i.e. endophenotypes), targeting genetic variants that directly influence gene expression (i.e. cis-eQTLs) and utilising genetically isolated populations to reduce genetic and environmental noise and thus enhance association signals...
November 16, 2017: Journal of Human Genetics
Pir Salim Mahar, Nadeem H Butt, Syed Imtiaz Ali
PURPOSE: To determine the efficacy of locally produced Latanoprost in reducing the intraocular pressure (IOP) in patients with Primary open-angle glaucoma (POAG). DESIGN: Open-label, non-comparative, observational case study with non-probability purposive sampling. METHODS: A total of 48 patients (94 eyes) of either gender were recruited from glaucoma clinic with the diagnosis of POAG, having IOP of more than 21 mmHg. Patients were commenced on locally produced Latanoprost (Vislat 0...
December 5, 2017: International Ophthalmology
Dominique Mustur, Zakieh Vahedian, Jerome Bovet, Maneli Mozaffarieh
Background: The purpose of this research is to analyze retinal venous pressure (RVP) of both eyes of patients who visited a Swiss ophthalmic practice and compare values among the following groups of patients with primary open-angle glaucoma (POAG), Flammer syndrome (FS), and metabolic syndrome (MetS). Methods: RVP was measured in both eyes of all patients who visited a Swiss ophthalmic practice during March 2016 till November 2016, and the results were analyzed retrospectively...
December 2017: EPMA Journal
Marcus Ang, Chelvin C A Sng
PURPOSE OF REVIEW: The aim of this review is to describe the relationship between Descemet membrane endothelial keratoplasty (DMEK) and glaucoma. RECENT FINDINGS: Glaucoma after DMEK is a serious complication that may cause permanent visual loss, affect donor endothelial cells and graft survival. The mechanisms of raised intraocular pressure (IOP) after DMEK include reverse pupillary block in the early postoperative period, and steroid response in the late phase...
December 4, 2017: Current Opinion in Ophthalmology
Pooyan Kazemian, Mariel S Lavieri, Mark P Van Oyen, Chris Andrews, Joshua D Stein
PURPOSE: To generate personalized forecasts of how patients with open-angle glaucoma (OAG) experience disease progression at different intraocular pressure (IOP) levels to aid clinicians with setting personalized target IOPs. DESIGN: Secondary analyses using longitudinal data from 2 randomized controlled trials. PARTICIPANTS: Participants with moderate or advanced OAG from the Collaborative Initial Glaucoma Treatment Study (CIGTS) or the Advanced Glaucoma Intervention Study (AGIS)...
December 1, 2017: Ophthalmology
Yuan Fang, Qingqing Long, Xiaoqian Wang, Rui Jiang, Xinghuai Sun
Objective: The aim of this study was to investigate the incidence, risk factors, and treatment of elevated intraocular pressure (IOP) 1 year after vitrectomy in eyes without a history of glaucoma or ocular hypertension. Patients and methods: This retrospective study comprised 256 eyes from 256 consecutive patients without a history of glaucoma or ocular hypertension who underwent vitrectomy and were followed up for 1 year. The incidence of elevated IOP at 1 year after vitrectomy was calculated...
2017: Clinical Ophthalmology
Narumon Keorochana, Sutheera Kunasuntiwarakul, Isaraporn Treesit, Raveewan Choontanom
Objective: The aim of this study was to evaluate the efficacy and safety of preoperative posterior subtenon injection of triamcinolone acetonide (PSTA) in noninfectious uveitic patients with secondary glaucoma undergoing primary trabeculectomy with mitomycin C. Design: This was a retrospective study. Patients and methods: We reviewed the medical records of 10 noninfectious uveitic patients, who had received a single preoperative PSTA 40 mg/1 mL, with secondary glaucoma undergoing primary trabeculectomy with mitomycin C...
2017: Clinical Ophthalmology
Ashwinee Ragam, David C Ritterband, Emily C Waisbren, Julia Mathew-Padiyedathu, Joann Kang, John A Seedor
PURPOSE: To analyze clinical outcomes and intraocular pressure (IOP) control following scleral-glued intraocular lens (IOL) fixation in eyes with pseudoexfoliation (PXF). METHODS: A retrospective chart review and outcome analysis was performed on a series of eyes undergoing glue-assisted, scleral-fixated ('scleral-glued') IOL insertion in the setting of PXF and poor or absent capsular support. RESULTS: 28 eyes were included in the study. The indications for scleral-glued IOL fixation included late endocapsular IOL dislocation (21/28, 75%), exchange for iris-fixated IOL due to complication (4/28, 14%), subluxed crystalline lens (2/28, 7%), and aphakia after complicated cataract surgery (1/28, 4%)...
December 1, 2017: Journal of Glaucoma
Janet B Serle, L Jay Katz, Eugene McLaurin, Theresa Heah, Nancy Ramirez-Davis, Dale W Usner, Gary D Novack, Casey C Kopczynski
PURPOSE: To evaluate the efficacy and ocular and systemic safety of netarsudil 0.02% ophthalmic solution, a rho-kinase inhibitor and norepinephrine transporter inhibitor, in patients with open-angle glaucoma and ocular hypertension. DESIGN: Double-masked, randomized non-inferiority clinical trials. METHODS: After a washout of all pre-study ocular hypotensive medications, eligible patients were randomized to receive netarsudil 0.02%, q.d., timolol 0...
November 30, 2017: American Journal of Ophthalmology
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