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Glaucoma AND IOP

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https://www.readbyqxmd.com/read/29026287/ocular-pharmacokinetics-and-tolerability-of-bimatoprost-ophthalmic-solutions-administered-once-or-twice-daily-in-rabbits-and-clinical-dosing-implications
#1
Jie Shen, Margot L Goodkin, Warren Tong, Mayssa Attar
PURPOSE: Fixed-combination medications can benefit patients requiring multiple agents to lower their intraocular pressure (IOP), but combining agents with complementary mechanisms of action is challenging if their dosing frequency differs. This study compares in vivo pharmacokinetic and ocular tolerability of bimatoprost 0.01% ophthalmic solutions dosed once or twice daily. Reports of twice-daily dosing in glaucoma patients are also reviewed. METHODS: New Zealand White rabbits were administered bimatoprost 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29022951/safety-of-fixed-drug-combination-in-post-operative-cataract-patients-at-tertiary-care-centre-in-south-india
#2
M Vidyadevi, A Anuradha, G Rashmi, R Shilpa, S Nishath
INTRODUCTION: Cataract is any opacification in lens or its capsule, which accounts for about 50% of treatable blindness worldwide. The prevalence of cataract in India is about 62.6%. The incidence of post operative endophthalmitis ranges from 0.05% - 0.14% and so the use of post-operative antibiotics and steroids is necessary to control infection and prevent inflammation. Fixed drug combinations not only cut the cost but also the dosage and improve the compliance of patients in the immediate post operative period...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29022950/diabetes-mellitus-and-the-risk-of-primary-open-angle-glaucoma
#3
P Lavaju, S Shah, S Sharma, R Maskey
BACKGROUND: Diabetes mellitus (DM) is one of the risk factors for Primary open angle glaucoma (POAG). Inclusion of DM as a risk factor for POAG is controversial. The objectives of the study were to investigate whether Type II (T2) DM is a risk factor for POAG and to determine central corneal thickness (CCT) in the subjects with T2DM and to examine the relationship between T2DM and intraocular pressure (IOP). MATERIALS AND METHODS: A comparative cross sectional study was conducted including 189 subjects of age > 40 years...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29022762/polymorphism-rs11656696-in-gas7-is-not-associated-with-primary-open-angle-glaucoma-in-a-saudi-cohort
#4
Altaf A Kondkar, Taif A Azad, Faisal A Almobarak, Hatem Kalantan, Tahira Sultan, Saleh A Al-Obeidan, Khaled K Abu-Amero
AIMS: To conduct a case-control study to investigate the association between the polymorphism rs11656696 located in the growth arrest-specific 7 gene on human chromosome 17p13.1 and primary open angle glaucoma (POAG). METHODS: The polymorphism rs11656696 was genotyped using the TaqMan(®) assay in 187 subjects comprising 92 unrelated POAG cases and 95 controls of Saudi Arabian origin. RESULTS: Association analysis between cases and controls revealed no significant genotype distribution under additive (p = 0...
October 12, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29022296/efficacy-and-safety-of-intracameral-bevacizumab-for-treatment-of-neovascular-glaucoma
#5
Jun Young Ha, Mi Sun Sung, Sang Woo Park
PURPOSE: To evaluate the long-term efficacy and safety of intracameral bevacizumab in patients with neovascular glaucoma. METHODS: This retrospective study included 26 eyes of 26 neovascular glaucoma patients who received intracameral bevacizumab injection between January 2013 and May 2015, and were followed-up for at least 1 year. All patients were treated with topical and/or systemic intraocular pressure (IOP)-lowering medications, intracameral bevacizumab, and panretinal photocoagulation (PRP)...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29016520/episcleral-venous-outflow-a-potential-outcome-marker-for-istent-surgery
#6
Cristina Bostan, Paul Harasymowycz
PURPOSE: (1) To propose the use of episcleral venous outflow (EVO) as an outcome marker of iStent surgery, and an EVO grading scale. (2) To determine the association of EVO with: (a) postoperative intraocular pressure (IOP) and medication burden; (b) iStent patency status. PATIENTS AND METHODS: Retrospective cohort study including 151 glaucomatous eyes having undergone iStent-phacoemulsification surgery. Demographic and preoperative data (IOP, number of anti-glaucoma medications, glaucoma type and stage, maximal IOP) were collected...
October 9, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28992424/long-term-outcome-of-intravitreal-bevacizumab-followed-by-ahmed-valve-implantation-in-the-management-of-neovascular-glaucoma
#7
Rajen Tailor, Matt T Kinsella, Jonathan C Clarke
BACKGROUND: To report the outcome of intravitreal Bevacizumab followed by Ahmed valve implantation in the management of neovascular glaucoma in a patient group with extended follow-up. METHODS: The records of 16 patients (18 eyes) with neovascular glaucoma refractory to medical therapy who presented to a single surgeon between 2006-2008 were reviewed. Patients received pan-retinal photocoagulation and then intravitreal Bevacizumab followed by Ahmed valve implantation...
October 9, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28991834/spontaneous-retinal-venous-pulsation-in-unilateral-primary-open-angle-glaucoma-with-low-intraocular-pressure
#8
EunJi Lee, Tae-Woo Kim, Jung-Ah Kim, Ji Ah Kim, Hyunjoong Kim
PURPOSE: The aim of this study was to investigate the presence of spontaneous retinal venous pulsation (SVP) in patients with unilateral primary open-angle glaucoma (POAG) and low intraocular pressure (IOP). MATERIALS AND METHODS: The SVP of 93 POAG patients with unilateral glaucoma and untreated IOP of ≤21 mm Hg was assessed using the movie tool of a confocal scanning laser ophthalmoscope (Spectralis HRA; Heidelberg Engineering). The frequency of SVP was compared between the glaucomatous and fellow eyes...
October 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28991617/goniotomy-with-a-single-use-dual-blade-short-term-results
#9
Michael D Greenwood, Leonard K Seibold, Nathan M Radcliffe, Syril K Dorairaj, Ahmad A Aref, Jesús Jimenez Román, Gabriel S Lazcano-Gomez, Jason K Darlington, Suhail Abdullah, Mark C Jasek, Khaled A Bahjri, John P Berdahl
PURPOSE: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of a single-use dual blade (Kahook) in patients with mild to end-stage glaucoma. SETTING: International multicenter ophthalmic care centers. DESIGN: Prospective interventional case series. METHODS: Consecutive patients with glaucoma who had phacoemulsification plus goniotomy with the single-use dual blade were enrolled in this study. Each center collected deidentified clinical data, including preoperative and postoperative IOP, medication use, adverse events, and whether additional surgery was required during a 6-month follow-up...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28991150/two-year-results-after-deep-sclerectomy-with-nonabsorbable-uveoscleral-implant-esnoper-clip-surgical-area-analysis-using-anterior-segment-optical-coherence-tomography
#10
Pau Romera-Romero, Jordi Loscos-Arenas, Aina Moll-Udina, Nevena Romanic-Bubalo, Jordi Castellvi-Manent, Xavier Valldeperas
PURPOSE: To report 2-year results of deep sclerectomy (DS) with mitomycin C and the uveoscleral implant Esnoper-Clip (AJL Ophthalmics, Álava, Spain), a nonabsorbable hema implant, and the morphologic analysis of the surgical area with anterior segment optical coherence tomography (AS-OCT). MATERIALS AND METHODS: In total, 41 eyes of 41 patients with medically uncontrolled open angle glaucoma who underwent DS with the uveoscleral implant were included in this prospective interventional study...
October 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28990066/integrated-microarray-analysis-provided-novel-insights-to-the-pathogenesis-of-glaucoma
#11
Jinhui Wang, Daofei Qu, Jinghong An, Guoming Yuan, Yufu Liu
Glaucoma is characterized as a visual field defect, which is the second most common cause of blindness. The present study performed an integrated analysis of microarray studies of glaucoma derived from Gene Expression Omnibus (GEO). Following the identification of the differentially expressed genes (DEGs) in glaucoma compared with normal control (NC) tissues, the functional annotation, glaucoma‑specific protein‑protein interaction (PPI) network and transcriptional regulatory network constructions were performed...
October 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28988897/outcomes-and-prognostic-factors-of-cataract-surgery-in-adult-extreme-microphthalmos-with-axial-length-18-mm-or-corneal-diameter-8-mm
#12
Tianyu Zheng, Zhanghua Chen, Jie Xu, Yating Tang, Qi Fan, Yi Lu
PURPOSE: To study the long-term visual outcomes, complications and prognostic factors for cataract surgery in extreme microphthalmos. DESIGN: Prospective cohort study. METHODS: Thirty eyes with simple microphthalmos [11 eyes, axial length (AL) <18 mm], complex microphthalmos [8 eyes, AL <18 mm] and relative anterior microphthalmos [RAM, 11 eyes, corneal diameter (CD) <8 mm] who underwent cataract surgery (phacoemulsification) in our hospital were followed for a mean of 25...
October 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28987446/role-of-laser-peripheral-iridotomy-in-pigmentary-glaucoma-and-pigment-dispersion-syndrome-a-review-of-the-literature
#13
REVIEW
A Labbé, J Buffault, B Leray, A Bouillot, C Baudouin
PURPOSE: Pigment dispersion syndrome (PDS) is characterized by a structural abnormality of the posterior surface of the iris causing contact with the zonular fibers. It can lead to an open-angle glaucoma secondary to pigment dispersion into the trabecular meshwork. Laser peripheral iridotomy (PI) has been proposed as a treatment for pigmentary glaucoma (PG) and pigment dispersion syndrome (PDS) by reducing the dispersion of pigment. The goal of this review was to assess the effects of PI for PDS and PG...
October 4, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28987318/co-instillation-of-nano-solid-magnesium-hydroxide-enhances-corneal-permeability-of-dissolved-timolol
#14
Noriaki Nagai, Fumihiko Ogata, Hiroko Otake, Naohito Kawasaki, Yosuke Nakazawa, Kazutaka Kanai, Norio Okamoto, Yoshikazu Shimomura
We prepared magnesium hydroxide (MH) nanoparticles by a bead mill method, and investigated whether the co-instillation of MH nanoparticles improves the low transcorneal penetration of water-soluble drugs, such as the anti-glaucoma eye drug timolol maleate (TM). MH particle size was decreased by the bead mill treatment to a mean particle size of 71 nm. In addition, the MH nanoparticles were highly stable. Next, we demonstrated the effect of MH nanoparticles on the corneal surface. MH shows only slight solubility in lacrimal fluid, and the instillation of MH nanoparticles for 14 days did not affect the behavior (balance of secretion and excretion) of the lacrimal fluid in rabbit corneas...
October 5, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28986598/hydrogen-sulfide-protects-retinal-ganglion-cells-against-glaucomatous-injury-in-vitro-and-in-vivo
#15
Hanhan Liu, Fabian Anders, Solon Thanos, Carolina Mann, Aiwei Liu, Franz H Grus, Norbert Pfeiffer, Verena Prokosch-Willing
Purpose: Hydrogen sulfide (H2S) is recognized as a novel third signaling molecule and gaseous neurotransmitter. Recently, cell protective properties within the central nervous and cardiovascular system have been proposed. Our purpose was to analyze the expression and neuroprotective effects of H2S in experimental models of glaucoma. Methods: Elevated IOP was induced in Sprague-Dawley rats by means of episcleral vein cauterization. After 7 weeks, animals were killed and the retina was analyzed with label-free mass spectrometry...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28986387/determination-of-reference-values-for-intraocular-pressure-and-schirmer-tear-test-results-in-clinically-normal-domestic-donkeys-equus-asinus
#16
Masoud Selk Ghaffari, Amin Sabzevari, SeyedMehdi Ghamsari, Hussein Shad
This study was conducted to establish normal reference range for the Schirmer tear test (STT) and intraocular pressure (IOP) in clinically normal donkeys for use in clinical practice. Sixteen adult Ethiopian domestic donkeys were used in this study. Complete ophthalmic examinations were performed without chemical restraint. STT values were evaluated in both eyes of all donkeys using a commercial STT strip. IOP was measured in both eyes with a Tono-Pen Vet (Reichert. USA) without using regional nerve blocks...
October 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28984715/suprachoroidal-bleeding-after-xen-gel-implantation
#17
Verena Prokosch-Willing, Urs Vossmerbaeumer, Esther Hoffmann, Norbert Pfeiffer
PURPOSE: To report for the first time a clinical case of suprachoroidal bleeding after XEN45®gel implantation. OBSERVATIONS: A 84-year old female patient with pseudoexfoliation glaucoma with intraocular pressure (20 mm Hg) above target despite maximal IOP lowering therapy was scheduled for XEN45® gel implantation. The XEN45® gel implantation went without complications and was properly placed in the anterior chamber and beneath the conjunctiva. On the first postoperative day, the patient presented with an IOP of 4 mm Hg, a functioning bleb and a deep anterior chamber...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28984710/risk-factors-associated-with-glaucomatous-progression-in-pseudoexfoliation-patients
#18
Yeji Moon, Kyung Rim Sung, Joon Mo Kim, Seong Hee Shim, Chungkwon Yoo, Ji Hye Park
PURPOSE: To investigate risk factors associated with glaucomatous progression in pseudoexfoliation glaucoma (PXG) patients. PATIENTS AND METHODS: A retrospective observational study with a total of 48 PXG patients and age-, sex-, and visual-field (VF) test mean-deviation (MD)-matched 48 primary open angle glaucoma (POAG) patients recruited from three university-based hospitals. Glaucomatous progression was defined by two criteria, either optic disc/retinal nerve fiber layer photographic assessment or serial VF data...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28983095/long-term-outcome-of-combined-trabeculotomy-trabeculectomy-by-a-single-surgeon-in-patients-with-primary-congenital-glaucoma
#19
D Sood, A Rathore, I Sood, G Singh, N N Sood
PurposeAssess long-term outcome of combined trabeculotomy-trabeculectomy (CTT) in primary congenital glaucoma (PCG).MethodsData of PCG patients treated with CTT by a single surgeon between 1976 and 1993 were reviewed for reduction in intraocular pressure (IOP), visual acuities, surgical success rates, and need for repeat surgeries at last follow-up (FU). At the last FU, IOP<21 mm Hg without any topical antiglaucoma medication (TAM) was complete success and with 1-2 TAMs was qualified success. IOP reduction ≥30% without any TAM was modified complete success and with 1-2 TAMs was modified qualified success...
October 6, 2017: Eye
https://www.readbyqxmd.com/read/28982956/the-laser-in-glaucoma-and-ocular-hypertension-light-trial-a-multicentre-randomised-controlled-trial-baseline-patient-characteristics
#20
Evgenia Konstantakopoulou, Gus Gazzard, Victoria Vickerstaff, Yuzhen Jiang, Neil Nathwani, Rachael Hunter, Gareth Ambler, Catey Bunce
PURPOSE: The laser in glaucoma and ocular hypertension (LiGHT) trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is superior to initial treatment with topical medication for primary open angle glaucoma (POAG) or ocular hypertension (OHT). DESIGN: LiGHT is a prospective unmasked, multicentre, pragmatic, randomised controlled trial (RCT). PARTICIPANTS: 718 previously untreated patients with POAG or OHT were recruited at 6 UK centres between 2012 and 2014...
October 5, 2017: British Journal of Ophthalmology
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