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Glaucoma AND IOP

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https://www.readbyqxmd.com/read/28319643/grooved-glaucoma-drainage-devices-that-continuously-deliver-cyclosporine-a-decrease-postsurgical-scar-formation-in-rabbit-eyes
#1
Zhaoxing Dai, Xiaobo Yu, Jianguo Sun, Xinghuai Sun
Purpose: To study the functional outcomes of filtration surgery by implanting improved glaucoma drainage devices (GDDs) comprising surface grooves and a composite coating of cyclosporine A (CsA) and PLGA in experimental rabbit eyes. Methods: Improved GDDs were designed and prepared by modifying normal GDD with surface grooves and a CsA-PLGA composite coating. Normal GDDs, grooved GDDs (G-GDDs), and G-GDDs with a CsA-PLGA composite coating (CsA@G-GDD) were implanted into 18 rabbit eyes (six eyes per group)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28316196/-clinical-observation-on-the-treatment-of-untreatable-childhood-glaucoma-with-microcatheter-assisted-trabeculotomy
#2
H Z Wang, M Li, M Hu, Y W Wang, Y Shi, W W Wang, N L Wang
Objective: To evaluate the efficacy of microcatheter-assisted trabeculotomy for untreatable childhood glaucoma with traditional surgeries repeatedly. Methods: Clinical charts of fifteen cases (16 eyes) with childhood glaucoma patients from Beijing Tongren Hospital were retrospectively analyzed. All eyes had previously received 2 or more traditional anti-glaucoma surgeries. We performed microcatheter-assisted trabeculotomy for these patients. The intraocular pressure (IOP), numbers of anti-glaucoma medications and post-operative complications were analyzed...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28314955/outcome-of-descemet-stripping-automated-endothelial-keratoplasty-in-eyes-with-an-ahmed-glaucoma-valve
#3
Patrick J Chiam, Robert Cheeseman, Vivian W Ho, Vito Romano, Anshoo Choudhary, Mark Batterbury, Stephen B Kaye, Colin E Willoughby
PURPOSE: The purpose was to investigate the survival of Descemet stripping automated endothelial keratoplasty (DSAEK) in eyes with an Ahmed glaucoma valve (AGV). METHODS: The study had a retrospective case-series of patients with an AGV in the anterior chamber undergoing a DSAEK. Included in the analysis were graft size, number of previous operations, post-operative glaucoma medications, post-operative intraocular pressure (IOP) control, graft size and donor factors (age, endothelial cell density, and post-mortem time)...
March 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28301497/long-term-outcomes-of-ciliary-sulcus-versus-capsular-bag-fixation-of-intraocular-lenses-in-children-an-ultrasound-biomicroscopy-study
#4
Yun-E Zhao, Xian-Hui Gong, Xue-Ning Zhu, He-Ming Li, Meng-Jun Tu, Terry G Coursey, Stephen C Pflugfelder, Feng Gu, Ding Chen
PURPOSE: To evaluate the long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses (IOLs) in children after pediatric cataract surgery. METHODS: IOL was implanted in the ciliary sulcus in 21 eyes of 14 children, and in the capsular bag in 19 eyes of 12 children for the treatment of pediatric cataract in an institutional setting. Ultrasound biomicroscopy (UBM) was performed. Main outcome measures included IOL decentration, IOL tilt, anterior chamber depth (ACD), angle-opening distance at 500 μm (AOD500), trabecular-iris angle (TIA), best-corrected visual acuity (BCVA), intraocular pressure (IOP), and incidence of postoperative complications...
2017: PloS One
https://www.readbyqxmd.com/read/28300743/four-dimensional-microscope-integrated-optical-coherence-tomography-to-enhance-visualization-in-glaucoma-surgeries
#5
Neel Dave Pasricha, Paramjit Kaur Bhullar, Christine Shieh, Christian Viehland, Oscar Mijail Carrasco-Zevallos, Brenton Keller, Joseph Adam Izatt, Cynthia Ann Toth, Pratap Challa, Anthony Nanlin Kuo
We report the first use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT) capable of live four-dimensional (4D) (three-dimensional across time) imaging intraoperatively to directly visualize tube shunt placement and trabeculectomy surgeries in two patients with severe open-angle glaucoma and elevated intraocular pressure (IOP) that was not adequately managed by medical intervention or prior surgery. We performed tube shunt placement and trabeculectomy surgery and used SS-MIOCT to visualize and record surgical steps that benefitted from the enhanced visualization...
January 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28300644/the-connective-tissue-phenotype-of-glaucomatous-cupping-in-the-monkey-eye-clinical-and-research-implications
#6
REVIEW
Hongli Yang, Juan Reynaud, Howard Lockwood, Galen Williams, Christy Hardin, Luke Reyes, Cheri Stowell, Stuart K Gardiner, Claude F Burgoyne
In a series of previous publications we have proposed a framework for conceptualizing the optic nerve head (ONH) as a biomechanical structure. That framework proposes important roles for intraocular pressure (IOP), IOP-related stress and strain, cerebrospinal fluid pressure (CSFp), systemic and ocular determinants of blood flow, inflammation, auto-immunity, genetics, and other non-IOP related risk factors in the physiology of ONH aging and the pathophysiology of glaucomatous damage to the ONH. The present report summarizes 20 years of technique development and study results pertinent to the characterization of ONH connective tissue deformation and remodeling in the unilateral monkey experimental glaucoma (EG) model...
March 12, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28291960/trabeculectomy-with-ologen-versus-mitomycin-c-in-juvenile-open-angle-glaucoma-a-1-year-study
#7
Fathi El-Sayyad, Heba Magdy Ahmed El-Saied, Mohamad Amr Salah Eddin Abdelhakim
BACKGROUND: We assessed bleb morphology and the intraocular pressure (IOP)-lowering effect of trabeculectomy with ologen compared to mitomycin C (MMC) in juvenile open-angle glaucoma (JOAG). METHODS: This is a prospective interventional comparative study conducted on 40 eyes (20 patients) with medically uncontrolled JOAG, randomly operating one eye for trabeculectomy with ologen (group A: 20 eyes) and the other with MMC (group B: 20 eyes). IOP measurement, SITA standard perimetry, and spectral domain optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) thickness were all done pre- and postoperatively...
March 15, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28291477/the-efficacy-of-two-trabecular-bypass-stents-compared-to-one-in-the-management-of-open-angle-glaucoma
#8
Anton Vlasov, Won I Kim
OBJECTIVES: To compare the outcomes of combined cataract surgery with two trabecular microbypass stents compared to one in patients with open-angle glaucoma. METHODS: Patients with primary open-angle glaucoma were included. Primary outcome measures were intraocular pressure (IOP), postoperative medications, and postoperative adverse events. RESULTS: The average patient age was 73.2 years. Thirty-nine eyes had phacoemulsification and one stent implanted (Group 1); 30 eyes had phacoemulsification and two stents implanted (Group 2)...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28291197/-long-term-results-of-combined-surgery-for-open-angle-glaucoma
#9
I Ya Baranov, I V Shiryaev, N V Mitrofanova, N A Molodkina, L I Balashevich
AIM: to comparatively evaluate the hypotensive effect of minimally invasive (type 1) and basic (type 2) subscleral removing of the external wall of Schlemm's canal with subsequent laser trabeculopuncture in patients with open-angle glaucoma (POAG). MATERIAL AND METHODS: The main group included 60 patients (64 eyes) treated with the minimally invasive technique. The control group included 105 patients (105 eyes), who underwent the type 2 surgery. RESULTS: After sinusotomy, intraocular pressure (IOP) decreased by 25% of its preoperative values in most patients (in 90...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28289948/relationship-between-intraocular-pressure-anterior-chamber-depth-and-lens-thickness-in-primary-open-angle-glaucoma-patients
#10
Bolajoko A Adewara, Bernice O Adegbehingbe, Oluwatoyin H Onakpoya, Chidi G Ihemedu
INTRODUCTION: To investigate the relationship between intraocular pressure (IOP), anterior chamber depth (ACD) and lens thickness (LT) in primary open-angle glaucoma (POAG) patients and compare with age- and sex-matched controls. METHODS: A cross-sectional analytical study of 62 newly diagnosed POAG patients compared with 62 age- and sex-matched control subjects in a tertiary eye clinic. Socio-demographic data and ocular examinations were documented. IOP was measured using the Goldmann applanation tonometer...
March 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28288603/a-cute-angle-closure-attack-after-an-intravitreal-bevacizumab-injection-for-branch-retinal-vein-occlusion-a-case-report
#11
Seongyong Jeong, Min Sagong, Woohyok Chang
BACKGROUND: Intravitreal injection is widely used to treat retinal vein occlusion, and acute angle closure (AAC) is an exceptional complication of intravitreal injection. The authors report a case of AAC that occurred immediately after administering intravitreal bevacizumab to treat branch retinal vein occlusion (BRVO). CASE PRESENTATION: A 65-year-old woman was referred to the retina clinic of a tertiary referral center for the treatment of macular edema secondary to BRVO...
March 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28288185/a-comparison-of-the-diagnostic-ability-of-vessel-density-and-structural-measurements-of-optical-coherence-tomography-in-primary-open-angle-glaucoma
#12
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To compare the diagnostic abilities of vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary open angle glaucoma (POAG) with that of the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements. METHODS: In a cross sectional study, 78 eyes of 50 control subjects and 117 eyes of 67 POAG patients underwent vessel density and structural measurements with spectral domain OCT...
2017: PloS One
https://www.readbyqxmd.com/read/28285308/clinical-features-of-japanese-patients-with-central-retinal-vein-occlusion-complicated-by-normal-tension-glaucoma-a-retrospective-study
#13
Teruyo Kida, Masanori Fukumoto, Takaki Sato, Hidehiro Oku, Tsunehiko Ikeda
PURPOSE: The association of central retinal vein occlusion (CRVO) with primary open-angle glaucoma (POAG) or ocular hypertension has been reported, and lowering intraocular pressure (IOP) helps to improve the retinal circulation in eyes with CRVO. However, the clinical features of CRVOs with normal-tension glaucoma (NTG) are not well known. Therefore, we investigated Japanese CRVO patients with NTG. METHODS: We retrospectively investigated 234 CRVO patients over 5 years, with follow-ups of more than 12 months, and evaluated the prevalence of glaucoma...
March 11, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28280945/influence-of-intraocular-pressure-reduction-on-progression-of-normal-tension-glaucoma-with-myopic-tilted-disc-and-associated-risk-factors
#14
Bo Ram Seol, Soa Kim, Dong Myung Kim, Ki Ho Park, Jin Wook Jeoung, Seok Hwan Kim
Purpose To evaluate the influence of intraocular pressure (IOP) reduction on progression of normal-tension glaucoma (NTG) with myopic tilted disc and to demonstrate the associated risk factors. METHODS: The medical records on 109 eyes of 109 NTG patients with myopic tilted discs who were followed up for more than 5 years and treated with topical medications were reviewed. Glaucoma progression was defined according to either structural or functional deterioration. Patients were divided into tertile groups according to the percent IOP reduction from the baseline, and the cumulative probability of NTG nonprogression of the upper- and lower-tertile groups was compared using Kaplan-Meier survival analysis...
March 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28272229/occult-lens-subluxation-related-to-laser-peripheral-iridotomy-a-case-report-and-literature-review
#15
Rongrong Hu, Xiaoyu Wang, Yang Wang, Yang Sun
RATIONALE: Laser peripheral iridotomy (LPI) is commonly performed as a primary treatment for acute primary angle closure glaucoma after administration of anti-glaucoma medications or for prevention of this condition. Minor complications may occur following LPI and most of them do not have deleterious consequences. We report a rare case of lens subluxation that has a possible relationship with LPI treatment. PATIENT CONCERNS: A 54-year-old female patient was initially referred for surgical treatment of medication-uncontrollable angle closure glaucoma in her left eye...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28270908/targeting-oxidative-stress-for-treatment-of-glaucoma-and-optic-neuritis
#16
REVIEW
Atsuko Kimura, Kazuhiko Namekata, Xiaoli Guo, Takahiko Noro, Chikako Harada, Takayuki Harada
Glaucoma is a neurodegenerative disease of the eye and it is one of the leading causes of blindness. Glaucoma is characterized by progressive degeneration of retinal ganglion cells (RGCs) and their axons, namely, the optic nerve, usually associated with elevated intraocular pressure (IOP). Current glaucoma therapies target reduction of IOP, but since RGC death is the cause of irreversible vision loss, neuroprotection may be an effective strategy for glaucoma treatment. One of the risk factors for glaucoma is increased oxidative stress, and drugs with antioxidative properties including valproic acid and spermidine, as well as inhibition of apoptosis signal-regulating kinase 1, an enzyme that is involved in oxidative stress, have been reported to prevent glaucomatous retinal degeneration in mouse models of glaucoma...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28270491/twenty-four-hour-intraocular-pressure-monitoring-with-the-sensimed-triggerfish-contact-lens-effect-of-body-posture-during-sleep
#17
Laura Beltran-Agulló, Yvonne M Buys, Farzana Jahan, Colin M Shapiro, John G Flanagan, Jason Cheng, Graham E Trope
PURPOSE: To determine the difference in relative intraocular pressure (IOP) measured by the SENSIMED Triggerfish (TF) contact lens in flat compared with 30° head-up sleeping positions in patients with progressive primary open-angle glaucoma or normotensive glaucoma, based on recent or recurrent disc haemorrhage. DESIGN: Prospective, randomised, cross-over, open-label comparative study. METHODS: IOP was monitored for 24 hours using TF on two separate sessions...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28269436/development-of-ocular-viscosity-characterization-method
#18
Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam
Glaucoma is the second leading cause for blindness. Irreversible and progressive optic nerve damage results when the intraocular pressure (IOP) exceeds 21 mmHg. The elevated IOP is attributed to blocked fluid drainage from the eye. Methods to measure the IOP are widely available, but methods to measure the viscous response to blocked drainage has yet been developed. An indentation method to characterize the ocular flow is developed in this study. Analysis of the load-relaxation data from indentation tests on drainage-controlled porcine eyes showed that the blocked drainage is correlated with increases in ocular viscosity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269242/a-smartphone-based-system-for-assessing-intraocular-pressure
#19
A Mariakakis, E Wang, S Patel, J C Wen
The measurement of intraocular pressure (IOP) is an important vital sign for the eye, particularly for the diagnosis of glaucoma. Procedures for measuring IOP have been used by eye care professionals for over 100 years, but those without access to such professionals often go undiagnosed. We present a smartphone-based system that can be operated by minimally trained users to measure IOP. The system emulates fixed-force tonometry using a low-cost mechanical attachment to the smartphone. Video is captured through the attachment and then processed in real-time to provide an absolute estimate of the patient's intraocular pressure...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269212/low-cost-rapid-prototyping-of-liquid-crystal-polymer-based-magnetic-microactuators-for-glaucoma-drainage-devices
#20
Hyunsu Park, Simon John, Hyowon Lee
Glaucoma is one of the leading causes of blindness in the world. Although there is no cure for glaucoma, pharmaceutical or surgical interventions are known to delay the progression of this debilitating disease. In recent years, implantation of glaucoma drainage devices (GDD) have increased due to their ability to manage IOP better than other therapeutic approaches. However, only 50% of the implanted devices remain functional after 5 years often due to biofouling. Here, we report our latest progress towards developing self-clearing GDDs using integrated magnetic microactuators...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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