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Glaucoma AND IOP

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https://www.readbyqxmd.com/read/29677370/topical-ripasudil-suppresses-retinal-ganglion-cell-death-in-a-mouse-model-of-normal-tension-glaucoma
#1
Kei Akaiwa, Kazuhiko Namekata, Yuriko Azuchi, Hiroki Sano, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Yoshinori Mitamura, Takayuki Harada
Purpose: To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma. Methods: Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 KO mice from 5 to 12 weeks old. Optical coherence tomography, multifocal electroretinograms, the measurement of intraocular pressure (IOP), and histopathology analyses were performed at 5, 8, and 12 weeks old...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677364/long-anterior-lens-zonules-and-intraocular-pressure
#2
Daniel K Roberts, Tricia L Newman, Mary Flynn Roberts, Bruce A Teitelbaum, Janis E Winters
Purpose: To investigate the relation between intraocular pressure (IOP) and the idiopathic long anterior zonule (LAZ) trait. Methods: Patients presenting for primary eye care were examined for LAZ, identified as radially oriented zonular fibers with central extension >1.0 mm beyond the normal anterior lens insertion zone (estimated via slit lamp beam length). Ocular, systemic health, and lifestyle data were collected via comprehensive exam and questionnaire. Multivariate regression was used to assess the relationship between IOP (Goldmann) and LAZ...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29675390/childhood-glaucoma-profile-in-dakahelia-egypt-a-retrospective-study
#3
Tharwat H Mokbel, Eman M El Hefney, Sherein M Hagras, Ahmed A ALNagdy, Amani E Badawi, Manal A Kasem, Shereen M El Shaer
AIM: To analyze childhood glaucoma regarding its demographics, presentations, different causes and surgical modalities used among patients in Dakahelia and to apply the Childhood Glaucoma Research Network (CGRN) classification retrospectively to evaluate its convenience. METHODS: A retrospective study in which the medical files of all glaucoma patients <16 years old presented to Mansoura Ophthalmic Center, Mansoura University from 2014 to 2017, were retrieved and analyzed...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675383/clinical-outcomes-of-patterned-laser-trabeculoplasty-as-adjuvant-therapy-in-open-angle-glaucoma-and-ocular-hypertension
#4
Gustavo Espinoza, Leonardo Castellanos, Ignacio Rodriguez-Una, Paul Anthony Camacho, Juan Camilo Parra
AIM: To assess the efficacy and safety of patterned laser trabeculoplasty (PLT) as an adjunctive treatment in open angle glaucoma (OAG) or ocular hypertension (OHT) patients who were under antiglaucoma medical treatment. METHODS: This study was a retrospective review of primary or secondary OAG patients and OHT patients with medically uncontrolled (≥18 mm Hg) intraocular pressure (IOP) who underwent 360° PLT from June 2016 to August 2016. Follow-up visits at week 1, and 1, 3 and 6mo were performed...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675382/long-term-outcomes-of-uveitic-glaucoma-treated-with-ahmed-valve-implant-in-a-series-of-chinese-patients
#5
Ning Bao, Zheng-Xuan Jiang, Paul Coh, Li-Ming Tao
AIM: To report long-term outcomes of secondary glaucoma due to uveitis treated with Ahmed glaucoma valve (AGV) implantation in a series of Chinese patients. METHODS: The retrospective study included 67 eyes from 56 patients with uveitic glaucoma who underwent AGV implantation. Success of the treatment was defined as patients achieving intraocular pressure (IOP) levels between 6 and 21 mm Hg with or without additional anti-glaucoma medications and/or a minimum of 20% reduction from baseline IOP...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675377/efficacy-of-autologous-conjunctival-flap-on-repairing-the-late-onset-filtering-bleb-leakage
#6
Jian-Gang Xu, Jing Zhong, Yang-Fan Yang, Ming-Kai Lin, Xing Liu, Min-Bin Yu
AIM: To evaluate the effectiveness of autologous conjunctival flap surgery for repairing the late-onset filtering bleb leakage after trabeculectomy. METHODS: This study retrospectively reviewed 106 eyes from 106 patients with late-onset filtering bleb leakage after trabeculectomy who received autologous conjunctival flap surgery at the Zhongshan Ophthalmic Centre from 2005 to 2015. The basic information was recorded, and the interval time between trabeculectomy and autologous conjunctival flap surgery as well as related risk factors, intraocular pressure (IOP), anterior chamber depth (ACD) and best corrected visual acuity (BCVA) were analysed...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675274/efficacy-and-safety-of-switching-prostaglandin-analog-monotherapy-to-tafluprost-timolol-fixed-combination-therapy
#7
Kazuyoshi Kitamura, Tatsuya Chiba, Fumihiko Mabuchi, Kiyotaka Ishijima, Shu Omoto, Fumiko Kashiwagi, Takashi Godo, Satoshi Kogure, Teruhiko Goto, Takashi Shibuya, Jhoji Tanabe, Shigeo Tsukahara, Tadaharu Tsuchiya, Toyoaki Tsumura, Takaharu Tokunaga, Osamu Hosaka, Tetsunori Saito, Kenji Kashiwagi
Purpose: To assess the efficacy and safety of switching from prostaglandin analog (PGA) monotherapy to tafluprost/timolol fixed-combination (Taf/Tim) therapy. Subjects and Methods: Patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who had received PGA monotherapy for at least 3 months were enrolled. Patients were examined at 1, 2, and 3 months after changing therapies. Subsequently, the patients were returned to PGA monotherapy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29673260/glaucoma-progression-and-its-relationship-with-corrected-and-uncorrected-intraocular-pressure-in-eyes-with-history-of-refractive-corneal-surgery
#8
Junki Kwon, Kyung Rim Sung, Jaehyuck Jo, Sung Ho Yang
PURPOSE: To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS: Total 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and central corneal thickness were measured at the time of glaucoma diagnosis. Three IOP measurements, i.e., uncorrected IOP (UC IOP) and corrected IOP calculated by applying the Kohlhaas (CK IOP) and Ehlers (CE IOP) formulas, were used...
April 20, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29669171/prostaglandin-analogues-and-nitric-oxide-contribution-in-the-treatment-of-ocular-hypertension-and-glaucoma
#9
REVIEW
Francesco Impagnatiello, Elena Bastia, Nicoletta Almirante, Stefania Brambilla, Brigitte Duquesroix, Angela C Kothe, Michael V W Bergamini
In patients with ocular hypertension or glaucoma all treatments aim at lowering intraocular pressure (IOP) by modulating aqueous humor (AH) production and/or uveoscleral and trabecular meshwork /Schlemm's canal AH drainage. Prostaglandin (PG) analogues are considered the 'gold standard', and are the most frequently used IOP-lowering agents. Recent data support an important role of nitric oxide (NO) in regulating IOP. Thus novel PG analogues carrying a NO-donating moiety were recently advanced. Latanoprostene bunod (LBN) and NCX 470, respectively a NO-donating derivative of latanoprost and bimatoprost, are examples of such compounds...
April 18, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29665040/discovery-characterization-and-clinical-utility-of-prostaglandin-agonists-for-the-treatment-of-glaucoma
#10
REVIEW
Peter G Klimko, Najam A Sharif
Topical ophthalmic formulations of analogs of the endogenous arachidonic acid cyclooxygenase metabolite, prostaglandin F2α (PGF2α ), are the standard of care for treating the blinding disease glaucoma. These are the most potent and efficacious medical therapies for lowering intraocular pressure (IOP), the most important identified risk factor for disease progression. They have few side-effects and offer the convenience of once-a-day dosing. It was initially believed that endogenous PGs raised IOP and caused substantial ocular surface adverse effects...
April 17, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29662301/conventional-trabeculectomy-versus-trabeculectomy-with-the-ex-press-%C3%A2-mini-glaucoma-shunt-differences-in-postoperative-interventions
#11
Naoki Tojo, Mitsuya Otsuka, Atsushi Hayashi
Purpose: To compare the postoperative interventions and outcomes between conventional trabeculectomy and trabeculectomy with the Ex-PRESS® mini-glaucoma shunt device (Ex-Press). Methods: This was a retrospective, comparative, single-facility study. We analyzed the cases of 108 glaucoma patients who underwent trabeculectomy and were followed for >1 year. Thirty-nine eyes underwent a conventional trabeculectomy (conventional group) and 69 eyes underwent a trabeculectomy with an Ex-Press (Ex-Press group)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29662300/the-effects-of-repeated-ozurdex-injections-on-ocular-hypertension
#12
Sepehr Bahadorani, Chelsey Krambeer, Kendall Wannamaker, Wayne Tie, Michael Jansen, Jason Espitia, Jeong-Hyeon Sohn, Michael A Singer
Purpose: The purpose of this study was to correlate the degree of ocular hypertension with the number of Ozurdex injections. Methods: Intraocular pressure (IOP) fluctuations for a total of 183 injections were studied over a period of at least 12 months. The main indications for treatment were uveitis, diabetic macular edema, and retinal vein occlusion. Results: Results of the study demonstrate that repeated Ozurdex injections do not increase the frequency of IOP spikes beyond 30 mmHg...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29655641/is-newer-necessarily-better-the-evolution-of-incisional-glaucoma-surgery-over-the-last-100-years
#13
Eve J Higginbotham, Dominique Alexis
PURPOSE: To examine the progress made in glaucoma incisional surgery and determine if there has been sufficient progress to meet the needs of glaucoma patients. DESIGN: Perspective: Literature Review METHODS: This is a retrospective assessment of key milestones in the evolution of glaucoma incisional surgery and an evaluation of the risks and the benefits of these procedures. Benefits are defined as effective reduction in intraocular pressure (IOP) and protecting visual function, while risks are defined as safety and complications for our patients...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29651824/effect-of-optical-aberrations-on-intraocular-pressure-measurements-using-a-microscale-optical-implant-in-ex-vivo-rabbit-eyes
#14
Samuel J Han, Haeri Park, Jeong Oen Lee, Hyuck Choo
Elevated intraocular pressure (IOP) is the only modifiable major risk factor of glaucoma. Recently, accurate and continuous IOP monitoring has been demonstrated in vivo using an implantable sensor based on optical resonance with remote optical readout to improve patient outcomes. Here, we investigate the relationship between optical aberrations of ex vivo rabbit eyes and the performance of the IOP sensor using a custom-built setup integrated with a Shack-Hartmann sensor. The sensor readouts became less accurate as the aberrations increased in magnitude, but they remained within the clinically acceptable range...
April 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29651340/changes-in-flow-density-measured-using-optical-coherence-tomography-angiography-after-istent-insertion-in-combination-with-phacoemulsification-in-patients-with-open-angle-glaucoma
#15
Maged Alnawaiseh, Viktoria Müller, Larissa Lahme, Ralph Laurent Merté, Nicole Eter
Purpose: To evaluate changes in flow density after the implantation of a trabecular microbypass stent (iStent) in combination with cataract surgery. Methods: A total of 48 eyes of 48 patients, who underwent either cataract surgery alone (cataract group) or cataract surgery with implantation of two iStent inject devices (iStent group), were prospectively included in this study. Intraocular pressure (IOP) and flow density data before and after surgery were extracted and analyzed...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29649424/the-safety-and-efficacy-of-supraciliary-stenting-following-failed-glaucoma-surgery
#16
Nathan M Kerr, Jing Wang, Lucia Perucho, Keith Barton
PURPOSE: To evaluate the safety and efficacy of supraciliary stenting following failed glaucoma surgery. DESIGN: Interventional case series. METHODS: Setting: Moorfields Eye Hospital, London, United Kingdom. STUDY POPULATION: Twenty eyes from 20 patients with glaucoma refractory to prior glaucoma surgery. INTERVENTION: Ab interno microstent (CyPass Micro-Stent; Alcon, Fort Worth, TX) implantation into the supraciliary space...
April 9, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29644538/a-review-of-the-clinical-usefulness-of-selective-laser-trabeculoplasty-in-exfoliative-glaucoma
#17
REVIEW
Andreas Katsanos, Anastasios G Konstas, Dimitrios G Mikropoulos, Luciano Quaranta, Irini C Voudouragkaki, Georgios P Athanasopoulos, Ioannis Asproudis, Miguel A Teus
In the last decade, selective laser trabeculoplasty (SLT) has been commonly used in the management of several different types of glaucoma, as either primary or adjunct therapy. The technique has an excellent safety profile and is at least as effective as argon laser trabeculoplasty. Although the actual mechanism of action of SLT remains unclear, evidence has shown that it does not induce morphologically evident trabecular meshwork alterations. SLT's non-disruptive mode of action offers the advantage of repeatability...
April 11, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29643784/clinical-efficacy-and-safety-of-the-ex-press-filtration-device-in-patients-with-advanced-neovascular-glaucoma-and-proliferative-diabetic-retinopathy
#18
Rana Hanna, Beatrice Tiosano, Shmuel Graffi, Dan Gaton
Background: The prognosis of conventional filtration surgery in eyes with neovascular glaucoma (NVG) is limited due to increased fibrovascular proliferation or bleeding. This study aims to evaluate the safety and efficacy of the EX-PRESS filtration device in the management of NVG associated with proliferative diabetic retinopathy (PDR). Methods: In this retrospective case series, we reviewed the medical records of patients diagnosed as having NVG associated with PDR who underwent EX-PRESS filtration surgery...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643342/the-relationship-between-outflow-resistance-and-trabecular-meshwork-stiffness-in-mice
#19
Ke Wang, Guorong Li, A Thomas Read, Iris Navarro, Ashim K Mitra, W Daniel Stamer, Todd Sulchek, C Ross Ethier
It has been suggested that common mechanisms may underlie the pathogenesis of primary open-angle glaucoma (POAG) and steroid-induced glaucoma (SIG). The biomechanical properties (stiffness) of the trabecular meshwork (TM) have been shown to differ between POAG patients and unaffected individuals. While features such as ocular hypertension and increased outflow resistance in POAG and SIG have been replicated in mouse models, whether changes of TM stiffness contributes to altered IOP homeostasis remains unknown...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29625080/the-effects-of-age-on-mitochondria-axonal-transport-and-axonal-degeneration-after-chronic-iop-elevation-using-a-murine-ocular-explant-model
#20
Elizabeth C Kimball, Joan L Jefferys, Mary E Pease, Ericka N Oglesby, Cathy Nguyen, Julie Schaub, Ian Pitha, Harry A Quigley
The purpose of this study was to compare younger and older mice after chronic intraocular pressure (IOP) elevation lasting up to 4 days with respect to mitochondrial density, structure, and movement, as well as axonal integrity, in an ex vivo explant model. We studied 2 transgenic mouse strains, both on a C57BL/6J background, one expressing yellow fluorescent protein (YFP) in selected axons and one expressing cyan fluorescent protein (CFP) in all mitochondria. Mice of 4 months or 14 months of age were exposed to chronic IOP by anterior chamber microbead injection for 14 h, 1, 3, or 4 days...
April 3, 2018: Experimental Eye Research
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