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Glaucoma AND IOP

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https://www.readbyqxmd.com/read/27921133/-evaluation-of-correction-formulas-for-tonometry-the-goldmann-applanation-tonometry-in-approximation-to-dynamic-contour-tonometry
#1
J Wachtl, M Töteberg-Harms, S Frimmel, C Kniestedt
BACKGROUND: Accurate determination of intraocular pressure (IOP) is essential for correct management of glaucoma. Goldmann applanation tonometry (GAT) is the gold standard for measuring IOP despite its limitations due to its dependence on corneal properties. With the aim of improving the accuracy of GAT readings, several correction formulas have been developed. OBJECTIVE: The aim of this study was to investigate the accuracy and clinical relevance of five correction equations for GAT...
December 5, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27920493/a-retrospective-analysis-of-intraocular-pressure-changes-after-cataract-surgery-with-the-use-of-prednisolone-acetate-1-versus-difluprednate-0-05
#2
Yael Kusne, Paul Kang, Robert E Fintelmann
PURPOSE: To compare the effect of topical prednisolone acetate 1% (PA) used after routine cataract surgery to the effect of difluprednate 0.05% (DFBA) used for the same indication on intraocular pressure (IOP). METHODS: An electronic query was created to gather information from all cataract surgeries between January 2010 and January 2015 within the electronic health record database at Barnet Dulaney Perkins, a multicenter, multiphysician private practice in Phoenix, Arizona...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27920489/bleb-related-infections-clinical-characteristics-risk-factors-and-outcomes-in-an-asian-population
#3
Zhu Li Yap, You Chuen Chin, Judy Yu-Fen Ku, Tat Keong Chan, Gillian Teh, Monisha Esther Nongpiur, Tin Aung, Shamira A Perera
PURPOSE: Comparison of the demographic, ocular, systemic and microbiological characteristics of eyes with bleb related infection (BRI) and bleb related endophthalmitis (BRE). METHODS: Retrospective chart review of patients with BRI from January 1996-July 2013. Identification done via the center's longstanding endophthalmitis audit, BRI audit and laboratory database identifying all conjunctival swabs from blebs. Blebitis was defined as anterior segment inflammation with mucopurulent material in or around the bleb, with anterior chamber cells but no hypopyon...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27916715/360-degree-trabeculotomy-for-medically-refractory-glaucoma-following-cataract-surgery-and-juvenile-open-angle-glaucoma
#4
Maria E Lim, Jennifer B Dao, Sharon F Freedman
PURPOSE: While angle surgeries show good success in primary congenital glaucoma, reported success in glaucoma following cataract surgery (GFCS) and juvenile open angle glaucoma (JOAG) is variable and with relatively short follow-up. We evaluated longer-term outcomes of 360-trabeculotomy for medically-refractory GFCS and JOAG. DESIGN: Retrospective case series. METHODS: First operated eyes of consecutive patients with medically-refractory GFCS and JOAG in a single-surgeon pediatric glaucoma practice who underwent illuminated microcatheter-assisted 360-trabeculotomy from 2/2008-6/2015 were reviewed...
December 1, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27916026/role-of-cyclic-amp-in-the-eye-of-glaucoma
#5
Myoung Sup Shim, Keun-Young Kim, Won-Kyu Ju
Glaucoma is characterized by a slow and progressive degeneration of optic nerve, including retinal ganglion cell (RGC) axons in the optic nerve head (ONH), leading to visual impairment. Despite the high prevalence, the biological basis of glaucoma pathogenesis still is not yet fully understood, and the factors contributing to its progression are currently not well characterized. Intraocular pressure (IOP) is the only modifiable risk factor, and reduction of IOP is the standard treatment for glaucoma. However, lowering IOP itself is not always effective for preserving visual function in patients with primary open-angle glaucoma...
December 5, 2016: BMB Reports
https://www.readbyqxmd.com/read/27915382/high-intensity-focused-ultrasound-treatment-in-patients-with-refractory-glaucoma
#6
Giuseppe Giannaccare, A Vagge, C Gizzi, A Bagnis, S Sebastiani, C Del Noce, M Fresina, C E Traverso, E C Campos
PURPOSE: To assess the safety and efficacy of ultrasound coagulation of the ciliary body in refractory glaucoma. METHODS: This prospective multicenter interventional study was conducted in two Italian university-affiliated glaucoma centers: St. Orsola-Malpighi Teaching Hospital (Bologna, Italy) and University Eye Clinic of Genoa (Genoa, Italy). The main inclusion criterion was the diagnosis of glaucoma with a baseline intraocular pressure (IOP) ≥ 21 mmHg while on maximum topical and systemic medical hypotensive treatment...
December 3, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27913991/24-hour-efficacy-and-ocular-surface-health-with-preservative-free-tafluprost-alone-and-in-conjunction-with-preservative-free-dorzolamide-timolol-fixed-combination-in-open-angle-glaucoma-patients-insufficiently-controlled-with-preserved-latanoprost-monotherapy
#7
Anastasios-Georgios Konstas, Konstadinos G Boboridis, Paraskevas Kapis, Konstantinos Marinopoulos, Irini C Voudouragkaki, Dimitrios Panayiotou, Dimitrios G Mikropoulos, Eirini Pagkalidou, Anna-Bettina Haidich, Andreas Katsanos, Luciano Quaranta
INTRODUCTION: The aim of the present study was to evaluate the 24-h efficacy, tolerability, and ocular surface health with preservative-free (PF) tafluprost and a PF triple drug regimen comprising tafluprost and dorzolamide/timolol fixed combination (DTFC) in open-angle glaucoma patients who were insufficiently controlled with preserved branded or generic latanoprost monotherapy and who exhibited signs or symptoms of ocular surface disease (OSD). METHODS: Prospective, observer-masked, crossover, comparison...
December 2, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27911106/time-course-of-conjunctival-hyperemia-induced-by-a-rho-kinase-inhibitor-anti-glaucoma-eye-drop-ripasudil-0-4
#8
Etsuko Terao, Shunsuke Nakakura, Yasuko Fujisawa, Yuki Fujio, Kanae Matsuya, Yui Kobayashi, Hitoshi Tabuchi, Tsuyoshi Yoneda, Atsuki Fukushima, Yoshiaki Kiuchi
PURPOSE: We investigated the detailed time course of conjunctival hyperemia induced by ripasudil 0.4%, a novel Rho-kinase inhibitor anti-glaucoma eye drop, in healthy subjects. METHODS: We recruited 51 healthy subjects and administered ripasudil 0.4% in their right eye. We evaluated conjunctival hyperemia using slit lamp photography and measured the intraocular pressure (IOP) using the Icare PRO Rebound Tonometer at baseline and after 5, 15, 30, 60, 90, and 120 min...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27906813/truncation-of-in-situ-baerveldt-glaucoma-drainage-device-for-treatment-of-late-persistent-postoperative-hypotony
#9
Philip P Chen
PURPOSE: To describe a new technique to treat late persistent hypotony after Baerveldt glaucoma drainage device surgery. METHODS: Review of 2 cases treated with in situ truncation of one or both wings of the Baerveldt device, combined with permanent but releasable tube occlusion. RESULTS: Two eyes with persistent hypotony underwent in situ truncation of one or both wings of the Baerveldt device with resolution of hypotony. Recurrence of elevated intraocular pressure (IOP) in both cases required reversal of tube occlusion, after which the IOP has remained both well controlled and sufficiently elevated to avoid complications of hypotony over 13 and 43 months...
November 30, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27906810/a-comparative-analysis-of-goldmann-tonometry-correction
#10
Magdalena Asejczyk-Widlicka, Wieslaw Srodka, Barbara K Pierscionek
PURPOSE: The measurement of intraocular pressure (IOP) by Goldmann applanation tonometry (GAT) is based on assumptions about corneal parameters. To correct for variations in corneal curvature and thickness, a number of equations have been proposed. This study evaluates the in vivo accuracy of these equations from individuals with primary open-angle glaucoma and compared them with measurements taken using the Pascal dynamic contour tonometer (DCT), which makes no assumptions about the corneal geometry or biomechanics...
November 30, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27905333/effect-of-cataract-surgery-on-intraocular-pressure-in-supine-and-lateral-decubitus-body-postures
#11
Ji-Hye Park, Chungkwon Yoo, Jong-Suk Song, Shan C Lin, Yong Yeon Kim
PURPOSE: To investigate the effect of phacoemulsification on intraocular pressure (IOP) in different recumbent body postures including supine and lateral decubitus (LD) positions. MATERIALS AND METHODS: This prospective, observational study included patients who had no glaucoma and who had planned to undergo phacoemulsification and intraocular lens implantation in one eye. Before and 1 month after cataract surgery, IOP was measured in both eyes using the Tono-Pen AVIA...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898468/update-on-ciliary-body-laser-procedures
#12
Behzad Amoozgar, Eileen N Phan, Shan C Lin, Ying Han
PURPOSE OF REVIEW: There are currently various options available for glaucoma treatment procedures ranging from laser to penetrating to nonpenetrating surgeries. Innovations in glaucoma surgical therapeutics include features such as external application, focused tissue effects, and minimal manipulation as these factors all help lower the risk of side-effects in addition to increasing the success rate of the treatment. Traditional diode laser transscleral cyclophotocoagulation (TSCPC) is invasive and destructive...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27897119/glaucoma-hot-topics-in-pharmacology
#13
Shiama I Balendra, Parth Arvind Shah, Mishank Jain, Andrzej Grzybowski, Francesca M Cordeiro
BACKGROUND: Glaucoma comprises a group of neurodegenerative diseases resulting in retinal ganglion cell death within the optic nerve head. It is projected to affect almost 80 million people worldwide by 2020. The condition's asymptomatic nature translates to over half of glaucoma sufferers being unaware of their condition. By the time of diagnosis, irreversible blindness is likely to have occurred. Prime areas of glaucoma research therefore include identification and optimization of risk factors for the disease, accurate and early diagnostic tools and novel therapeutic methods...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27893106/evidence-for-a-gpr18-role-in-diurnal-regulation-of-intraocular-pressure
#14
Sally Miller, Emma Leishman, Olivia Oehler, Laura Daily, Natalia Murataeva, Jim Wager-Miller, Heather Bradshaw, Alex Straiker
Purpose: The diurnal cycling of intraocular pressure (IOP) was first described in humans more than a century ago. This cycling is preserved in other species. The physiologic underpinning of this diurnal variation in IOP remains a mystery, even though elevated pressure is indicated in most forms of glaucoma, a common cause of blindness. Once identified, the system that underlies diurnal variation would represent a natural target for therapeutic intervention. Methods: Using normotensive mice, we measured the regulation of ocular lipid species by the enzymes fatty acid amide hydrolase (FAAH) and N-arachidonoyl phosphatidylethanolamine phospholipase (NAPE-PLD), mRNA expression of these enzymes, and their functional role in diurnal regulation of IOP...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27890826/relevant-variations-and-neuroprotecive-effect-of-hydrogen-sulfide-in-a-rat-glaucoma-model
#15
Shouyue Huang, Ping Huang, Xiaohong Liu, Zhongjing Lin, Jing Wang, Shuo Xu, Lei Guo, Christopher Kai-Shun Leung, Yisheng Zhong
Glaucoma is an irreversible and blinding neurodegenerative disease of the eye, and is characterized by progressive loss of retinal ganglion cells (RGCs). Since endogenous hydrogen sulfide (H2S) was reported to be involved in neurodegeneration in the central nervous system, the authors aimed to develop a chronic ocular hypertension (COH) rat model simulating glaucoma and therein test the H2S level together with the retinal protein expressions of related synthases, and further investigated the effect of exogenous H2S supplement on RGC survival...
November 24, 2016: Neuroscience
https://www.readbyqxmd.com/read/27884546/-results-of-trabeculectomy-with-anti-vgef-therapy-in-the-treatment-of-neovascular-glaucoma-secondary-to-retinal-vein-occlusion-report-of-21%C3%A2-cases-followed-at-bukavu-eye-clinic-from-january-1%C3%A2-to-december-31th-2015
#16
T B Kabesha, D Kabesha, V Maloba, C Mwamba, B Chenge, A Mukalay
PURPOSE: To evaluate the results of anti-VGEF with trabeculectomy in the treatment of neovascular glaucoma, a severe complication of retinal vein occlusion (RVO). PATIENTS AND METHODS: This is a prospective case series of consecutive patients with neovascular glaucoma secondary to retinal vein occlusion. All patients underwent panretinal photocoagulation and a mean of 3 anti-VEGF injections prior to trabeculectomy. Ophthalmic parameters were recorded pre- and postoperatively: visual acuity (VA), intraocular pressure (IOP), iris examination, gonioscopy and fundus examination, and as necessary, fluorescein angiography...
November 21, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27882243/glaukos-istent-inject%C3%A2-trabecular-micro-bypass-implantation-associated-with-cataract-surgery-in-patients-with-coexisting-cataract-and-open-angle-glaucoma-or-ocular-hypertension-a-long-term-study
#17
Pedro Arriola-Villalobos, Jose Maria Martinez-de-la-Casa, David Diaz-Valle, Laura Morales-Fernandez, Cristina Fernandez-Perez, Julian Garcia-Feijoo
Purpose. To evaluate the long-term efficacy and safety of the iStent inject device (Glaukos Corporation, Laguna Hills, CA) combined with phacoemulsification in patients with coexistent cataract and open-angle glaucoma or ocular hypertension (OHT). Methods. A prospective, uncontrolled, nonrandomized, interventional case series study was conducted in patients with both mild or moderate open-angle glaucoma or OHT and cataract. Patients underwent cataract surgery along with the implant of two iStent inject devices...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27881155/selective-laser-trabeculoplasty-for-early-glaucoma-analysis-of-success-predictors-and-adjusted-laser-outcomes-based-on-the-untreated-fellow-eye
#18
Mikael Chun, Carolina P B Gracitelli, Flavio S Lopes, Luis G Biteli, Michele Ushida, Tiago S Prata
BACKGROUND: To identify success predictors and to study the role of the fellow untreated eye as a co-variable for adjustment of intraocular pressure (IOP) outcomes following selective laser trabeculoplasty (SLT) in early open-angle glaucoma (OAG) patients. METHODS: A case series was carried out. Patients with uncontrolled early OAG or ocular hypertension (inadequate IOP control requiring additional treatment) underwent SLT (one single laser session) performed by the same surgeon in a standardized fashion...
November 23, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27878430/short-term-safety-of-dexamethasone-implant-for-treatment-of-macular-edema-due-to-retinal-vein-occlusion-in-eyes-with-glaucoma-or-treated-ocular-hypertension
#19
Sofia Theodoropoulou, Abdallah A Ellabban, Robert L Johnston, Helena Cilliers, Quresh Mohamed, Ahmed B Sallam
PURPOSE: To report the short-term safety of dexamethasone implants to treat macular edema due to retinal vein occlusion (RVO), in eyes with treated glaucoma or ocular hypertension at baseline using an as-needed re-treatment regimen. METHODS: Retrospective clinical database study from two centers using the same electronic medical record system. Extracted data included: intraocular pressure (IOP), visual acuity (VA), central 1 mm retinal thickness (CRT) by optical coherence tomography, phakic status, number of injections, glaucoma treatment, and peri-operative complications...
November 22, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27875486/evaluation-of-corneal-deformation-parameters-provided-by-the-corvis-st-tonometer-after-trabeculectomy
#20
Yuan Zong, Na Wu, Zhixuan Fu, Xiangmei Kong
PURPOSE: The aims of this study were to evaluate how the corneal deformation parameters provided by the Corvis ST tonometer (CST) were influenced by pressure-lowering ocular surgery, and to determine the correlations of intraocular pressure (IOP) and axial length (AL) with CST corneal deformation parameters. METHODS: This prospective 1-month study enrolled 22 subjects (22 eyes) who underwent trabeculectomy combined with mitomycin C. The corneal deformation parameters were measured using the CST...
November 21, 2016: Journal of Glaucoma
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