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Glaucoma AND IOP

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https://www.readbyqxmd.com/read/28239491/efficacy-and-tolerability-of-travoprost-0-004-timolol-0-5-fixed-dose-combination-for-the-treatment-of-primary-open-angle-glaucoma-or-ocular-hypertension-inadequately-controlled-with-beta-blocker-monotherapy
#1
Simon Fabian Lerner, Ki Ho Park, Douglas A Hubatsch, Valeriy Erichev, Jose A Paczka, Timothy V Roberts
Objective. To evaluate the efficacy and tolerability of travoprost 0.004%/timolol 0.5% fixed-dose combination (TTFC) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) inadequately controlled on beta-blocker monotherapy. Methods. In this phase IV, open-label study, 156 patients on beta-blocker monotherapy with mean intraocular pressure (IOP) between 18 and 32 mmHg were randomized (no washout period) to receive TTFC for 8 weeks (TTFC group) or to continue beta-blocker monotherapy for 4 weeks followed by TTFC for the remaining 4 weeks (beta-blocker group)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28238754/cross-linked-actin-networks-clans-in-glaucoma
#2
REVIEW
Jaclyn Y Bermudez, Michela Montecchi-Palmer, Weiming Mao, Abbot F Clark
One of the major causes of decreased vision, irreversible vision loss and blindness worldwide is glaucoma. Increased intraocular pressure (IOP) is a major risk factor associated with glaucoma and its molecular mechanisms are not fully understood. The trabecular meshwork (TM) is the primary site of injury in glaucoma, and its dysfunction results in elevated IOP. The glaucomatous TM has increased extracellular matrix deposition as well as cytoskeletal rearrangements referred to as cross-linked actin networks (CLANs) that consist of dome like structures consisting of hubs and spokes...
February 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28237158/phaco-trabectome-versus-phaco-istent-in-patients-with-open-angle-glaucoma
#3
Khaliq Kurji, Christopher J Rudnisky, Jaspreet S Rayat, Sourabh Arora, Simrenjeet Sandhu, Karim F Damji, Michael W Dorey
OBJECTIVE: To investigate efficacy and safety of phaco-trabectome (PT) versus phaco-iStent (Pi) for intraocular pressure (IOP) control in open-angle glaucoma (OAG). DESIGN: Retrospective comparative case series. PARTICIPANTS: A total of 70 eyes of 55 patients with OAG underwent either PT surgery by a single surgeon or Pi (insertion of 2 stents) by another surgeon in Canada between January 2010 and December 2012. METHODS: The medical records of consecutive adult patients who underwent either PT or Pi surgery were reviewed...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28237157/modified-goniotomy-as-an-alternative-to-trabectome-in-primary-open-angle-glaucoma-and-pseudoexfoliation-glaucoma-1-year-results
#4
Milena Pahlitzsch, Johannes Gonnermann, Anna-Karina B Maier, Eckart Bertelmann, Matthias K J Klamann, Carl Erb
OBJECTIVE: To assess the outcome of modified goniotomy and trabeculotomy ab interno (Trabectome) surgery in adult primary open-angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma. DESIGN: Retrospective cohort outcome study. PARTICIPANTS: Two hundred and thirty-six eyes of 236 patients. METHODS: This cohort outcome study included 68 POAG (mean age: 65.7 ± 16.0 years) and 22 PEX glaucoma patients (mean age: 78...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28237155/graft-free-ahmed-valve-implantation-through-a-6-mm-scleral-tunnel
#5
Gdih Gdih, Kailun Jiang
OBJECTIVE: To evaluate the safety, efficacy, and cost savings of Ahmed glaucoma valve (AGV) tube implantation through a 6-mm scleral tunnel (graft-free technique). DESIGN: Retrospective cohort study. METHODS: The 95% confidence interval for fractional survival at any particular time was calculated using the Kaplan-Meier method. Failure was defined as (i) intraocular pressure (IOP) <6 mm Hg or >21 mm Hg or <20% IOP reduction on 2 consecutive visits after 12 months; (ii) additional surgical intervention to control IOP; or (iii) no light perception...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28231380/perioperative-medications-for-preventing-temporarily-increased-intraocular-pressure-after-laser-trabeculoplasty
#6
REVIEW
Linda Zhang, Jennifer S Weizer, David C Musch
BACKGROUND: Glaucoma is the international leading cause of irreversible blindness. Intraocular pressure (IOP) is the only currently known modifiable risk factor; it can be reduced by medications, incisional surgery, or laser trabeculoplasty (LTP). LTP reduces IOP by 25% to 30% from baseline, but early acute IOP elevation after LTP is a common adverse effect. Most of these IOP elevations are transient, but temporarily elevated IOP may cause further optic nerve damage, worsening of glaucoma requiring additional therapy, and permanent vision loss...
February 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28227682/development-of-ocular-viscosity-characterization-method
#7
Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam, Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam, David C C Lam, Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung
Glaucoma is the second leading cause for blindness. Irreversible and progressive optic nerve damage results when the intraocular pressure (IOP) exceeds 21 mmHg. The elevated IOP is attributed to blocked fluid drainage from the eye. Methods to measure the IOP are widely available, but methods to measure the viscous response to blocked drainage has yet been developed. An indentation method to characterize the ocular flow is developed in this study. Analysis of the load-relaxation data from indentation tests on drainage-controlled porcine eyes showed that the blocked drainage is correlated with increases in ocular viscosity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227476/a-smartphone-based-system-for-assessing-intraocular-pressure
#8
A Mariakakis, E Wang, S Patel, J C Wen, A Mariakakis, E Wang, S Patel, J C Wen, E Wang, A Mariakakis, S Patel, J C Wen
The measurement of intraocular pressure (IOP) is an important vital sign for the eye, particularly for the diagnosis of glaucoma. Procedures for measuring IOP have been used by eye care professionals for over 100 years, but those without access to such professionals often go undiagnosed. We present a smartphone-based system that can be operated by minimally trained users to measure IOP. The system emulates fixed-force tonometry using a low-cost mechanical attachment to the smartphone. Video is captured through the attachment and then processed in real-time to provide an absolute estimate of the patient's intraocular pressure...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227442/low-cost-rapid-prototyping-of-liquid-crystal-polymer-based-magnetic-microactuators-for-glaucoma-drainage-devices
#9
Hyunsu Park, Simon John, Hyowon Lee, Hyunsu Park, Simon John, Hyowon Lee, Simon John, Hyowon Lee, Hyunsu Park
Glaucoma is one of the leading causes of blindness in the world. Although there is no cure for glaucoma, pharmaceutical or surgical interventions are known to delay the progression of this debilitating disease. In recent years, implantation of glaucoma drainage devices (GDD) have increased due to their ability to manage IOP better than other therapeutic approaches. However, only 50% of the implanted devices remain functional after 5 years often due to biofouling. Here, we report our latest progress towards developing self-clearing GDDs using integrated magnetic microactuators...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224390/plga-nanoparticles-as-subconjunctival-injection-for-management-of-glaucoma
#10
Hamed A Salama, Mahmoud Ghorab, Azza A Mahmoud, Mayssa Abdel Hady
Nanoparticles fabricated from the biodegradable and biocompatible polymer, polylactic-co-glycolic acid (PLGA), could be a promising system for targeting ocular drug delivery. The objective of this work was to investigate the possibility of encapsulating brinzolamide in PLGA nanoparticles in order to be applied as a subconjunctival injection that could represent a starting point for developing new therapeutic strategies against increase in ocular pressure. The brinzolamide-loaded PLGA nanoparticles were fabricated using emulsion-diffusion-evaporation method with varying concentrations of Tween 80 or poloxamer 188 (Plx) in aqueous and organic phases...
February 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28223915/oral-delivery-of-a-synthetic-sterol-reduces-axonopathy-and-inflammation-in-a-rodent-model-of-glaucoma
#11
Wendi S Lambert, Brian J Carlson, Cathryn R Formichella, Rebecca M Sappington, Clarence Ahlem, David J Calkins
Glaucoma is a group of optic neuropathies associated with aging and sensitivity to intraocular pressure (IOP). The disease is the leading cause of irreversible blindness worldwide. Early progression in glaucoma involves dysfunction of retinal ganglion cell (RGC) axons, which comprise the optic nerve. Deficits in anterograde transport along RGC axons to central visual structures precede outright degeneration, and preventing these deficits is efficacious at abating subsequent progression. HE3286 is a synthetic sterol derivative that has shown therapeutic promise in models of inflammatory disease and neurodegenerative disease...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28223180/biomechanical-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#12
REVIEW
Cheri Stowell, Claude Burgoyne, Ernst R Tamm, C Ross Ethier
The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microarchitecture and anatomy; intraocular pressure (IOP); and cerebrospinal fluid pressure (CSFp). We note that connective tissue factors can vary significantly from one individual to the next, as well as regionally within an eye, and that the understanding of ONH biomechanics is hindered by anatomical differences between small-animal models of glaucoma (rats and mice) and humans...
February 18, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28223179/biological-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#13
REVIEW
Ernst R Tamm, C Ross Ethier, Claude Burgoyne, C Ross Ethier, Ernst R Tamm, Cheri Stowell, John E Dowling, Crawford Downs, Mark H Ellisman, Steven Fisher, Brad Fortune, Marcus Fruttiger, Tatjana Jakobs, Geoffrey Lewis, Claire H Mitchell, John Morrison, Sansar C Sharma, Ian Sigal, Michael Sofroniew, Lin Wang, Janey Wiggs, Samuel Wu, Richard H Masland
Intraocular pressure (IOP) is a critical risk factor in glaucoma, and the available evidence derived from experimental studies in primates and rodents strongly indicates that the site of IOP-induced axonal damage in glaucoma is at the optic nerve head (ONH). However, the mechanisms that cause IOP-induced damage at the ONH are far from understood. A possible sequence of events could originate with IOP-induced stress in the ONH connective tissue elements (peripapillary sclera, scleral canal and lamina cribrosa) that leads to an increase in biomechanical strain...
February 18, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28221702/localized-and-controlled-delivery-of-nitric-oxide-to-the-conventional-outflow-pathway-via-enzyme-biocatalysis-toward-therapy-for-glaucoma
#14
Rona Chandrawati, Jason Y H Chang, Ester Reina-Torres, Coline Jumeaux, Joseph M Sherwood, W Daniel Stamer, Alexander N Zelikin, Darryl R Overby, Molly M Stevens
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. An NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28221332/sustained-resolution-of-macular-retinoschisis-after-trabeculectomy-in-a-patient-with-progressive-glaucoma
#15
Rany Woo, Handan Akil, Nicole Koulisis, Lisa C Olmos de Koo, James C H Tan
PURPOSE: To evaluate the clinical characteristics of a patient with primary open-angle glaucoma in whom macular retinoschisis resolved completely after trabeculectomy consistently lowered intraocular pressure (IOP). METHODS: A single case report. RESULTS: We report a case of retinoschisis involving the macula in a patient with primary open-angle glaucoma in the absence of myopic maculopathy, optic nerve anomaly, or x-linked retinoschisis. The patient's glaucoma was associated with progressive visual field loss in the setting of IOP fluctuations related to posture...
February 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28220849/the-long-term-anterior-segment-configuration-after-pediatric-cataract-surgery-and-the-association-with-secondary-glaucoma
#16
Ding Chen, Xian-Hui Gong, He Xie, Xue-Ning Zhu, Jin Li, Yun-E Zhao
Secondary glaucoma constitutes major sight-threatening complication of pediatric cataract surgery, yet the etiology remains unclear. The purpose of this study was to investigate the long-term anterior segment configuration and the association with secondary glaucoma in pediatric pseudophakia. Ultrasound biomicroscopy (UBM) was performed on 40 eyes of 26 children underwent pediatric cataract surgery and intraocular lens (IOL) implantation. The anterior chamber depth (ACD), angle-opening distance at 500 μm (AOD500), trabecular-iris angle (TIA), central corneal thickness (CCT), structural abnormities, IOL position, IOP, and incidence of glaucoma were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218404/topical-medication-instillation-techniques-for-glaucoma
#17
REVIEW
Li Xu, Xuemei Wang, Meijing Wu
BACKGROUND: Glaucoma is a leading cause of irreversible blindness worldwide and the second most common cause of blindness after cataracts. The primary treatment for glaucoma aims to lower intraocular pressure (IOP) with the use of topical medicines. Topical medication instillation techniques, such as eyelid closure and nasolacrimal occlusion when instilling drops, have been proposed as potential methods to increase ocular absorption and decrease systemic absorption of the drops. OBJECTIVES: To investigate the effectiveness of topical medication instillation techniques compared with usual care or another method of instillation of topical medication in the management of glaucoma or ocular hypertension...
February 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28217551/cost-effectiveness-of-glaucoma-management-with-monotherapy-medications-in-egypt
#18
Amal Abd-Elaal El-Khamery, Amir Ibrahim Mohamed, Hassan Eisa Hassan Swify, Alaa Ibrahim Mohamed
Glaucoma is a serious chronic ophthalmic disease since it causes irreversible visual disability if untreated can lead to blindness. Treatment options include medications (classified into five major classes of drugs which are muscarinic cholinergic agonists, alpha-2 adrenergic agonists, beta-1 adrenergic antagonists, prostaglandins [PGs], and carbonic anhydrase inhibitors); use of laser therapy or conventional surgery. Pharmacoeconomic analysis helps in choosing among this variety of treatments. There is a great need for such analysis in Egypt since undergoing of it in different countries or societies may produce different results...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28216468/enhanced-ocular-efficacy-of-topically-delivered-dorzolamide-with-nanostructured-mucoadhesive-microparticles
#19
Chun Gwon Park, Young Kook Kim, Se-Na Kim, Seung Ho Lee, Beom Kang Huh, Min-A Park, Hyein Won, Ki Ho Park, Young Bin Choy
Dorzolamide eye drops are widely prescribed to reduce intraocular pressure (IOP) in the treatment of ocular hypertension and glaucoma. However, in an eye drop formulation, dorzolamide is rapidly cleared from the preocular space, hence requiring multiple daily administrations. Here, we sought to increase the preocular retention of dorzolamide using nanostructured, mucoadhesive microparticles (MUCO_NM) as carriers for topical delivery to the eye. MUCO_NM were prepared by freeze-milling dorzolamide-loaded, electrospun nanofibers composed of poly(lactic-co-glycolic acid) and polyethylene glycol...
February 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28215764/canthotomy-and-cantholysis-prior-to-ultrasound-circular-cyclocoagulation-uc3-%C3%A2-eye-tech-care-in-refractory-glaucoma
#20
A Fernández, J Raez-Balbastre, V Elipe, F Poyales
CASE REPORT: The case is presented on a patient with primary open-angle glaucoma treated with the novel ultrasound circular cyclocoagulation technique (UC3(®) [EyeTechCare, Rillieux La Pape, France]), who had previously undergone glaucoma surgery. Due to having extreme palpebral rigidity, worsened by the pre-operative local anesthesia injections, a canthotomy and cantholysis were needed to correctly position of the UC3(®) probe cone. Clinical outcome as regards the IOP and the surgical wound was very satisfactory...
February 16, 2017: Archivos de la Sociedad Española de Oftalmología
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