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https://www.readbyqxmd.com/read/29780782/combination-of-clinical-and-laboratory-characteristics-may-serve-as-a-potential-diagnostic-marker-for-torsion-on-mature-cystic-teratomas
#1
Ji Yun Lee, Whan Shin, Jeong Sook Kim, Joo Hyun Park, SiHyun Cho
Objective: The objective of this study was to evaluate clinical and laboratory characteristics of torsion on mature cystic teratomas (MCTs). In addition, we examined whether these factors could be helpful in diagnosing MCT torsion. Methods: A retrospective medical record review was conducted for 384 patients who had undergone surgery and histologically verified ovarian MCTs at single university hospital between July 2006 and May 2017. Patients with or without torsion groups were compared with respect to clinical presentation, laboratory findings and surgical course...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29775147/intraoperative-cochlear-nerve-mapping-with-the-mobile-cochlear-nerve-compound-action-potential-tracer-in-vestibular-schwannoma-surgery
#2
Nobuyuki Watanabe, Takuya Ishii, Kazuhiko Fujitsu, Shogo Kaku, Teruo Ichikawa, Kosuke Miyahara, Tomu Okada, Shin Tanino, Yasuhiro Uriu, Yuichi Murayama
OBJECTIVE The authors describe the usefulness and limitations of the cochlear nerve compound action potential (CNAP) mobile tracer (MCT) that they developed to aid in cochlear nerve mapping during vestibular schwannoma surgery (VSS) for hearing preservation. METHODS This MCT device requires no more than 2 seconds for stable placement on the nerve to obtain the CNAP and thus is able to trace the cochlear nerve instantaneously. Simultaneous bipolar and monopolar recording is possible. The authors present the outcomes of 18 consecutive patients who underwent preoperative useful hearing (defined as class I or II of the Gardner-Robertson classification system) and underwent hearing-preservation VSS with the use of the MCT...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29774995/-study-on-the-relationship-between-mct-1-and-p53-in-laryngeal-squamous-cell-carcinoma
#3
Y B Wang, O Xu, R J Zhang, C G Shan
Objective: The aim of this study is to investigate the expression and clinical significance of monocarboxylate transporter 1 (MCT-1) and p53 in laryngeal squamous cell carcinoma (LSCC). Method: Immunohistochemical staining of MCT-1 and p53 was carried out in 41 cases of laryngeal squamous cell carcinoma embedded in paraffin, and the relationship between positive expression and clinicopathological data was evaluated. All data were analyzed by SPSS software (Windows version 21.0). Result: In normal mucosa p53 expression was absent; while, the basal "stem cell" layer is highly enriched in MCT-1...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774103/bevacizumab-exacerbates-sinusoidal-obstruction-syndrome-sos-in-the-animal-model-and-increases-mmp-9-production
#4
Azin Jafari, Hanno Matthaei, Sven Wehner, Tolga Tonguc, Jörg C Kalff, Steffen Manekeller
Background: Thanks to modern multimodal treatment the ouctome of patients with colorectal cancer has experienced significant improvements. As a downside, agent specific side effects have been observed such as sinusoidal obstruction syndrome (SOS) after oxaliplatin chemotherapy (OX). Bevazicumab targeting VEGF is nowadays comprehensively used in combination protocols with OX but its impact on hepatotoxicity is thus far elusive and focus of the present study. Results: After MCT administration 67% of animals developed SOS...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29768985/effects-of-monoclonal-antibodies-against-nerve-growth-factor-on-healthy-bone-and-joint-tissues-in-mice-rats-and-monkeys-histopathologic-biomarker-and-microcomputed-tomographic-assessments
#5
Kathryn E Gropp, Cathy S Carlson, Mark G Evans, Cedo M Bagi, William J Reagan, Susan I Hurst, David L Shelton, Mark A Zorbas
Tanezumab, an anti-nerve growth factor (NGF) antibody, is in development for management of chronic pain. During clinical trials of anti-NGF antibodies, some patients reported unexpected adverse events requiring total joint replacements, resulting in a partial clinical hold on all NGF inhibitors. Three nonclinical toxicology studies were conducted to evaluate the effects of tanezumab or the murine precursor muMab911 on selected bone and joint endpoints and biomarkers in cynomolgus monkeys, Sprague-Dawley rats, and C57BL/6 mice...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29768485/choroidal-thickness-in-normal-indian-subjects-using-swept-source-optical-coherence-tomography
#6
Zeeshan Akhtar, Pukhraj Rishi, Ramasubramanian Srikanth, Ekta Rishi, Muna Bhende, Rajiv Raman
AIM: To determine choroidal thickness in healthy Indian subjects using Swept source optical coherence tomography (SS-OCT). METHODS: In this prospective, observational, cross-sectional study; healthy Indian subjects (n = 230) with no history of ocular and/or systemic disorders were enrolled in the study. Choroidal thickness was measured for 230 eyes using SS-OCT. Subjects were divided into six age groups. Main outcome measures were subfoveal choroidal thickness (SFCT) and macular choroidal thickness (MCT) up to 3 mm at 500-micron interval from the fovea was measured in eight different quadrants...
2018: PloS One
https://www.readbyqxmd.com/read/29768376/rare-case-of-squamous-cell-carcinoma-arising-in-a-recurrent-ovarian-mature-cystic-teratoma-of-a-young-woman-a-case-report-and-review-of-the-literature
#7
Xinge Feng, Lian Xu
RATIONALE: Malignant transformations of ovarian mature cystic teratomas (MCTs) occur rarely, especially in young women. Although it is extremely difficult to diagnose them, serum tumor marker level testing in combination with the use of imaging techniques may be useful in preoperative diagnosis. PATIENT CONCERNS: We present the case of a 31-year-old Chinese woman with the malignant transformation of an ovarian MCT. The patient had a history of oophorocystectomy due to an MCT of the right ovary 6 years prior and a gemellary pregnancy owing to in vitro fertilization and embryo transfer...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766500/konjac-glucomannan-octenyl-succinate-kgos-as-an-emulsifier-for-lipophilic-bioactive-nutrients-encapsulation
#8
Yun-Cheng Li, Geng Zhong, Fan-Bing Meng, Hua Yu, Da-Yu Liu, Lian-Xin Peng
BACKGROUND: Konjac glucomannan octenyl succinate (KGOS) has excellent emulsification properties and can potentially be used in the food industry as an emulsifier, stabilizer and microcapsule wall material. In present study, the in vitro digestion properties and emulsification capability and stability of KGOS were studied to evaluate the transport and encapsulation characteristics of KGOS to insoluble bioactive nutrients. RESULTS: Confocal scanning laser microscopy (CSLM) suggested that oil droplets could be encapsulated by KGOS into regular spheres...
May 15, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29764932/distribution-of-mast-cell-subtypes-in-interstitial-cystitis-implications-for-novel-diagnostic-and-therapeutic-strategies
#9
Shabana T Malik, Brian R Birch, David Voegeli, Mandy Fader, Vipul Foria, Alan J Cooper, Andrew F Walls, Bashir A Lwaleed
AIMS: To identify the presence and geographical distribution of mast cell (MC) subtypes: MCT (tryptase positive-chymase negative) and MCTC (tryptase positive-chymase positive) in bladder tissue. METHODS: Bladder tissue was obtained from patients with painful bladder syndrome/interstitial cystitis (n=14) and normal histology from University Hospital Southampton tissue bank. Sequential tissue slices were immunohistochemically stained for MC subtypes using anti-MC tryptase (for MCT and MCTC ) and anti-MC chymase (for MCTC )...
May 15, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29761973/-research-on-vigilance-detection-based-on-pulse-wave
#10
Yong Cao, Xuejun Jiao, Jinjin Pan, Jin Jiang, Jiahao Fu, Fenggang Xu, Hanjun Yang
This paper studied the rule for the change of vigilance based on pulse wave. 10 participants were recruited in a 95-minute Mackworth clock test (MCT) experiment. During the experiment, the vigilance of all participants were evaluated by Karolinska sleepiness scale (KSS) and Stanford sleepiness scale (SSS), and behavior data (the reaction time and the accuracy of target) and pulse wave signal of the participants were recorded simultaneously. The result indicated that vigilance of the participants can be divided into 3 classes: the first 30 minutes for high vigilance level, the middle 30 minutes for general vigilance level, and the last 30 minutes for low vigilance level...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29761247/beneficial-effects-of-fenofibrate-in-pulmonary-hypertension-in-rats
#11
Palak Galhotra, Pankaj Prabhakar, Himanshu Meghwani, Soheb A Mohammed, Sanjay Kumar Banerjee, Sandeep Seth, Milind P Hote, K H Reeta, Ruma Ray, Subir Kumar Maulik
Pulmonary hypertension (PH) is a morbid complication of cardiopulmonary as well as several systemic diseases in humans. It is rapidly progressive and fatal if left untreated. In the present study, we investigated the effect of PPARα agonist fenofibrate (FF) on monocrotaline (MCT)-induced PH in rats. FF, because of its pleiotropic property, could be helpful in reducing inflammation, oxidative stress, and reactive oxygen species. On day 1, MCT (50 mg/kg, s.c.) was given to all the rats in MCT, sildenafil, and FF group except normal control rats...
May 14, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29760703/the-increased-endogenous-sulfur-dioxide-acts-as-a-compensatory-mechanism-for-the-downregulated-endogenous-hydrogen-sulfide-pathway-in-the-endothelial-cell-inflammation
#12
Da Zhang, Xiuli Wang, Xiaoyu Tian, Lulu Zhang, Guosheng Yang, Yinghong Tao, Chen Liang, Kun Li, Xiaoqi Yu, Xinjing Tang, Chaoshu Tang, Jing Zhou, Wei Kong, Junbao Du, Yaqian Huang, Hongfang Jin
Endogenous hydrogen sulfide (H2 S) and sulfur dioxide (SO2 ) are regarded as important regulators to control endothelial cell function and protect endothelial cell against various injuries. In our present study, we aimed to investigate the effect of endogenous H2 S on the SO2 generation in the endothelial cells and explore its significance in the endothelial inflammation in vitro and in vivo . The human umbilical vein endothelial cell (HUVEC) line (EA.hy926), primary HUVECs, primary rat pulmonary artery endothelial cells (RPAECs), and purified aspartate aminotransferase (AAT) protein from pig heart were used for in vitro experiments...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755032/effects-of-mature-cystic-teratoma-on-reproductive-health-and-malignant-transformation-a-retrospective-analysis-of-80-cases
#13
Sefa Kurt, Hüseyin Aytuğ Avşar, Ömer Erbil Doğan, Hasan Bahadır Saatli, Uğur Saygılı
OBJECTIVE: Examining the cases of mature cystic teratoma (MCT) that are diagnosed and treated in our clinic regarding their association with fertility; and detecting the rate of malignant degeneration and the types of malignancies. MATERIAL AND METHODS: Patients, operated due to adnexal mass between April 2012 and August 2017 and diagnosed with MCT, were retrospectively examined. Mean age of the 80 cases, which met the criteria, was 30.60±10.5. 9 were suffering from infertility, according to hospital records...
May 14, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29752040/mesenchymal-stem-cell-derived-microvesicles-alleviate-pulmonary-arterial-hypertension-by-regulating-renin-angiotensin-system
#14
Zhenjun Liu, Jinghu Liu, Mengyuan Xiao, Junxian Wang, Feng Yao, Weikai Zeng, Liqin Yu, Yuejie Guan, Wenyan Wei, Zijian Peng, Kunpeng Zhu, Jin Wang, Zhongyuan Yang, Jixin Zhong, Jianying Chen
In recent years, microvesicles (MVs) derived from mesenchymal stem cells (MSCs) have been proved to be able to improve the outcome of pulmonary arterial hypertension (PAH) in many respects, but the underlying mechanisms of it still remain unclear. Because the renin-angiotensin system (RAS) has been found to be closely related to PAH, the present study was designed to investigate whether the effect of MSC-derived MVs on PAH was correlated with RAS. MVs were isolated and purified from bone marrow MSCs. PAH rat models were established by a single intraperitoneal injection of 1% monocrotaline (MCT, 50 mg/Kg)...
March 15, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29751839/metabolic-reprogramming-of-the-urea-cycle-pathway-in-experimental-pulmonary-arterial-hypertension-rats-induced-by-monocrotaline
#15
Hai-Kuo Zheng, Jun-Han Zhao, Yi Yan, Tian-Yu Lian, Jue Ye, Xiao-Jian Wang, Zhe Wang, Zhi-Cheng Jing, Yang-Yang He, Ping Yang
BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare systemic disorder associated with considerable metabolic dysfunction. Although enormous metabolomic studies on PAH have been emerging, research remains lacking on metabolic reprogramming in experimental PAH models. We aim to evaluate the metabolic changes in PAH and provide new insight into endogenous metabolic disorders of PAH. METHOD: A single subcutaneous injection of monocrotaline (MCT) (60 mg kg- 1 ) was used for rats to establish PAH model...
May 11, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29745970/mechanical-efficiency-of-high-versus-moderate-intensity-aerobic-exercise-in-coronary-heart-disease-patients-a-randomized-clinical-trial
#16
Koldobika Villelabeitia-Jaureguizar, Davinia Vicente-Campos, Alejandro Berenguel Senen, Verónica Verónica Hernández Jiménez, Lorena Lorena Ruiz Bautista, María Elvira Barrios Garrido-Lestache, Jose López Chicharro
BACKGROUND: Mechanical efficiency (ME) refers to the ability of an individual to transfer energy consumed by external work. A decreased ME, could represent an increased energy cost during exercise and may, therefore, be limited in terms of physical activity. This study aimed to compare the influence of two different exercise protocols: moderate continuous training (MCT) versus high intensity interval training (HIIT), as part of a cardiac rehabilitation program on ME values among coronary patients...
May 10, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29739582/the-critical-micelle-concentration-of-lecithin-in-bulk-oils-and-medium-chain-triacylglycerol-is-influenced-by-moisture-content-and-total-polar-materials
#17
JiSu Kim, Mi-Ja Kim, JaeHwan Lee
Effects of different moisture contents and oxidised compounds on the critical micelle concentration (CMC) of lecithin were determined in bulk oils and in medium-chain triacylglycerols (MCT). CMC of lecithin in MCT was significantly higher than that in other vegetable oils including olive, soybean, corn, and rapeseed oils (p < 0.05). Presence of moisture significantly affected the CMC of lecithin in MCT (p < 0.05). CMC of lecithin was high when the moisture content was below 900 ppm, whereas at a moisture content of 1000 ppm, CMC of lecithin decreased significantly (p < 0...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29718763/detection-of-melamine-in-milk-powder-using-mct-based-shortwave-infrared-hyperspectral-imaging-system
#18
Hoonsoo Lee, Moon S Kim, Santosh Lohumi, Byoung-Kwan Cho
Extensive research has been conducted on non-destructive and rapid detection of melamine in powdered foods in the last decade. While Raman and near-infrared (NIR) hyperspectral imaging techniques have been successful in terms of non-destructive and rapid measurement, they have limitations with respect to measurement time and detection capability, respectively. Therefore, the objective of this study was to develop a mercury cadmium telluride (MCT)-based short wave infrared (SWIR) hyperspectral imaging system and algorithm to detect melamine quantitatively in milk powder...
May 2, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29715570/what-tactics-should-a-surgeon-choose-to-treat-a-black-extracerebral-tumor-a-case-report-of-psammomatous-melanotic-schwannoma-of-meckel-s-cave-and-literature-review
#19
Galina I Moisak, Dmitry E Matsko, Sergey V Chernov, Aleksandr B Dmitriev, Mikhail E Amelin, Elena A Zhelbunova, Mikhail F Chernov, Jamil A Rzaev
BACKGROUND: Neoplasms located in Meckel's cave account for 0.2-0.5% of all intracranial tumors. This area is the site of many types of pathological lesions, most often trigeminal nerve schwannomas and meningiomas. Melanin-containing tumors are very rare in this area. These tumor types can be suspected if the MR-characteristics of a tumor has some differences in comparison with other types of central nervous system neoplasms. In fact, differential diagnosis of melanotic tumors is based mainly on the histopathological criteria and immunohistochemical profile...
April 28, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29713695/influence-of-oil-phase-composition-on-the-antifungal-and-mycotoxin-inhibitory-activity-of-clove-oil-nanoemulsions
#20
Jing Wan, Shaobin Zhong, Paul Schwarz, Bingcan Chen, Jiajia Rao
The influence of oil composition on the physical properties and antifungal and mycotoxin inhibitory activity of clove oil-in-water nanoemulsions was investigated. Physically stable clove oil-in-water nanoemulsions could be fabricated by incorporating either ≥75 wt% of corn oil or ≥50 wt% of medium chain triacylglycerol (MCT) into clove oil before homogenization to prevent Ostwald ripening. The clove oil-in-water nanoemulsions with mean diameters of <150 nm showed high physical stability over 30 days storage...
May 1, 2018: Food & Function
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