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https://www.readbyqxmd.com/read/28235483/effect-of-lipid-metabolism-on-male-fertility
#1
Namhyo Kim, Hitomi Nakamura, Hidetake Masaki, Keiichi Kumasawa, Ken-Ichi Hirano, Tadashi Kimura
Cholesterol and lipid homeostasis is important for male fecundity. However, the plasma total cholesterol level does not reflect sperm concentration and motility. Adipose tissue in mammals is the main tissue contributing to the dynamic equilibrium of lipid synthesis and catabolism. However, recent studies suggested that local lipolysis has an important role in male fertility. If so, which plasma lipid metabolism parameter reflects sperm concentration and motility? Leptin receptor-deficient db/db mice show hyperphagia, hyperglycemia, hypercholesterolemia, hypertriglyceridemia, morbid obesity and are reported to be infertile...
February 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28227552/research-on-eeg-features-of-attended-unattended-vigilance
#2
Chang Sun, Runge Chen, Miao Tian, Xingwei An, Hongzhi Qi, Minpeng Xu, Xuemin Wang, Dong Ming, Peng Zhou, Chang Sun, Runge Chen, Miao Tian, Xingwei An, Hongzhi Qi, Minpeng Xu, Xuemin Wang, Dong Ming, Peng Zhou, Miao Tian, Minpeng Xu, Hongzhi Qi, Runge Chen, Dong Ming, Chang Sun, Xingwei An, Peng Zhou, Xuemin Wang
Vigilance refers to the brain alertness to objective things, including the concentration of attention and the capability to response emergencies. It is of great importance to study vigilance monitoring to avoid accidents caused by decrease of vigilance. In this study, traditional Mackworth Clock Test (MCT) was modified to induce decline of attended and unattended vigilance. We analyzed EEG features in different levels of attended vigilance and assessed unattended vigilance by amplitude of mismatch negative (MMN) which can be evoked by audio odd ball stimulations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28213866/5-aminosalicylic-acid-attenuates-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats-by-increasing-the-expression-of-nur77
#3
Ling-Yue Sun, Zong-Ye Cai, Jun Pu, Jian Li, Jie-Yan Shen, Cheng-de Yang, Ben He
The aim of this study is to investigate the effect of 5-aminosalicylic acid (5-ASA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats and its molecular mechanism. Sixty male Sprague-Dawley rats (250-300 g) were evenly randomized into six groups: control group; PAH group induced by MCT intraperitoneal injection (50 mg/kg) on day 1; and four PAH groups treated for 30 days from day 2 with 5-ASA at 50 (5-ASA-50 group), 100 (5-ASA-100 group), 150 (5-ASA-150 group), and 200 mg/kg/day (5-ASA-200 group), respectively...
February 17, 2017: Inflammation
https://www.readbyqxmd.com/read/28212825/inhibition-of-ubiquitin-proteasome-function-prevents-monocrotaline-induced-pulmonary-arterial-remodeling
#4
Yanting Zhu, Yinxia Wu, Wenhua Shi, Jian Wang, Xin Yan, Qingting Wang, Ya Liu, Lan Yang, Li Gao, Manxiang Li
AIMS: Previous study has indicated that inhibition of proteasome function ameliorates the development of pulmonary arterial hypertension (PAH), while its underlying mechanisms are still unclear. This study was performed to address these issues. MATERIAL AND METHODS: Male Sprague-Dawley (SD) rats were divided into five groups: control group, PAH group, vehicle treated PAH group, MG-132 treated PAH group and bortezomib treated PAH group. PAH model was established by a single intraperitoneal injection of monocrotaline (MCT)...
February 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28210959/glass-transition-in-hard-core-fluids-and-beyond-using-an-effective-static-structure-in-the-mode-coupling-theory
#5
S Amokrane, F Tchangnwa Nya, J M Ndjaka
The dynamical arrest in classical fluids is studied using a simple modification of the mode coupling theory (MCT) aimed at correcting its overestimation of the tendency to glass formation while preserving its overall structure. As in previous attempts, the modification is based on the idea of tempering the static pair correlations used as input. It is implemented in this work by computing the static structure at a different state point than the one used to solve the MCT equation for the intermediate scattering function, using the pure hard-sphere glass for calibration...
February 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28208313/diffusion-of-a-rouse-chain-in-porous-media-a-mode-coupling-theory-study
#6
Huai Ding, Huijun Jiang, Nanrong Zhao, Zhonghuai Hou
We use a kinetic mode-coupling theory (MCT) combining with generalized Langevin equation (GLE) to study the diffusion and conformational dynamics of a bead-spring Rouse chain (RC) dissolved in porous media. The media contains fluid particles and immobile matrix ones wherein the latter leads to the lack of translational invariance. The friction kernel ζ(t) used in the GLE can be obtained directly by adopting a simple density-functional approach in which the density correlators calculated by MCT equations of porous media serve as inputs...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207765/a-rapid-efficient-and-economic-device-and-method-for-the-isolation-and-purification-of-mouse-islet-cells
#7
Yin Zongyi, Zou Funian, Li Hao, Cheng Ying, Zhang Jialin, Li Baifeng
Rapid, efficient, and economic method for the isolation and purification of islets has been pursued by numerous islet-related researchers. In this study, we compared the advantages and disadvantages of our developed patented method with those of commonly used conventional methods (Ficoll-400, 1077, and handpicking methods). Cell viability was assayed using Trypan blue, cell purity and yield were assayed using diphenylthiocarbazone, and islet function was assayed using acridine orange/ethidium bromide staining and enzyme-linked immunosorbent assay-glucose stimulation testing 4 days after cultivation...
2017: PloS One
https://www.readbyqxmd.com/read/28198783/effect-of-moderate-versus-high-intensity-interval-exercise-training-on-heart-rate-variability-parameters-in-inactive-latin-american-adults-a-randomised-clinical-trial
#8
Robinson Ramírez-Vélez, Alejandra Tordecilla-Sanders, Luis Andrés Téllez-T, Diana Camelo-Prieto, Paula Andrea Hernández-Quiñonez, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso, Rodrigo Ramírez-Campillo, Mikel Izquierdo
We investigated the effect of moderate versus high-intensity interval exercise training on the HRV indices in physically inactive adults. Twenty inactive adults were randomly allocated to receive either moderate intensity training (MCT group) or high-intensity interval training (HIT group). The MCT group performed aerobic training at an intensity of 55-75%, which consisted of walking on a treadmill at 60-80% of the maximum heart rate (HRmax) until the expenditure of 300 kcal. The HIT group ran on a treadmill for 4 minutes at 85-95% peak HRmax and had a recovery of 4 minutes at 65% peak HRmax until the expenditure of 300 kcal...
February 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28191959/mitoxantrone-and-folate-tpgs2k-conjugate-hybrid-micellar-aggregates-to-circumvent-toxicity-and-enhance-efficiency-for-breast-cancer-therapy
#9
Nida El Islem Guissi, Huipeng Li, Yurui Xu, Farouk Semcheddine, Minglei Chen, Zhigui Su, Qineng Ping
Mitoxantrone (MTO) is a potent drug used to treat breast cancer; however, efforts to expand its clinical applicability have been restricted because of its high risk for cardiotoxicity. In this study, we successfully conjugated MTO or folic acid (FA) to a synthesized D-α-tocopheryl polyethylene glycol 2000 succinate (TPGS2k), herein, shortened to MCT and FCT, respectively. The two produced conjugates could self-assemble to form MCT micelles or MCT/FCT mixed micelles (FMCT) aiming to lower systemic toxicity, enhance entrapment efficiency, and provide a platform for targeted delivery...
February 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28190856/virilism-and-ectopic-expression-of-hsd17b5-in-mature-cystic-teratoma
#10
Yohei Kawaguchi, Hiroko Mizuno, Mai Horikawa, Mayuko Kano, Kengo Yamada, Fumiko Yamakawa, Takashi Maekawa, Yuto Yamazaki, Keely M McNamara, Hironobu Sasano, Masayuki Hayashi
Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7.3 ng/ml and 2.3 pg/ml, respectively, which were markedly in excess of the age adjusted female standard levels. Basal blood levels of steroid hormones and serum levels of 17-hydroxyprogesterone at 1 h after intravenous injection of adrenocorticotropic hormone demonstrated that 21-hydroxylase deficiency was not the underlying cause of her virilization...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28188954/comparative-glandular-trichome-transcriptome-based-gene-characterization-reveals-reasons-for-differential-menthol-biosynthesis-in-mentha-species
#11
Md Qussen Akhtar, Nida Qamar, Pallavi Yadav, Pallavi Kulkarni, Ajay Kumar, Ajit Kumar Shasany
The genes involved in menthol biosynthesis are reported earlier in Mentha × piperita. But the information on these genes is not available in Mentha arvensis. To bridge the gap in knowledge on differential biosynthesis of monoterpenes leading to compositional variation in the essential oil of these species, a comparative transcriptome analysis of the glandular trichome was carried out. In addition to the MVA and MEP pathway genes, about 210 and 196 different terpene synthases (TPS) transcripts were identified from annotation in M...
February 11, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28188080/the-effect-of-18f-fdg-pet-image-reconstruction-algorithms-on-the-expression-of-characteristic-metabolic-brain-network-in-parkinson-s-disease
#12
Petra Tomše, Luka Jensterle, Sebastijan Rep, Marko Grmek, Katja Zaletel, David Eidelberg, Vijay Dhawan, Yilong Ma, Maja Trošt
PURPOSE: To evaluate the reproducibility of the expression of Parkinson's Disease Related Pattern (PDRP) across multiple sets of 18F-FDG-PET brain images reconstructed with different reconstruction algorithms. METHODS: 18F-FDG-PET brain imaging was performed in two independent cohorts of Parkinson's disease (PD) patients and normal controls (NC). Slovenian cohort (20 PD patients, 20 NC) was scanned with Siemens Biograph mCT camera and reconstructed using FBP, FBP+TOF, OSEM, OSEM+TOF, OSEM+PSF and OSEM+PSF+TOF...
February 7, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28187784/let-7a-transfected-mesenchymal-stem-cells-ameliorate-monocrotaline-induced-pulmonary-hypertension-by-suppressing-pulmonary-artery-smooth-muscle-cell-growth-through-stat3-bmpr2-signaling
#13
Gesheng Cheng, Xingye Wang, Yongxin Li, Lu He
BACKGROUND: Cell-based gene therapy has become a subject of interest for the treatment of pulmonary arterial hypertension (PAH), a devastating disease characterized by pulmonary artery smooth muscle cell (PASMC) hyperplasia. Mesenchymal stem cells (MSCs) have been recently acknowledged as a potential cell vector for gene therapy. Here, we investigated the effect of MSC-based let-7a for PAH. METHODS: After isolation and identification of MSCs from rat bone marrow, cells were infected with recombinant adenovirus vector Ad-let-7a...
February 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28187460/effects-of-renal-denervation-on-monocrotaline-induced-pulmonary-remodeling
#14
Qian Liu, Jiyang Song, Dasheng Lu, Jie Geng, Zhixin Jiang, Kai Wang, Bin Zhang, Qijun Shan
Pulmonary artery hypertension (PAH) is a rapidly progressive disorder, which leads to right heart failure and even death. Overactivity of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system accounts for the development and progression of PAH. The role of renal denervation (RDN) in different periods of PAH has not been fully elucidated. A single intraperitoneal injection of monocrotaline (MCT, 60 mg/kg) was used to induce pulmonary remodeling in male Sprague Dawley rats (n = 40). After 24-hour of MCT administration, a subset of rats underwent RDN (RDN24h, n = 10); after 2-week of MCT injection, another ten rats received RDN treatment (RDN2w, n = 10) and the left 20 rats were divided to MCT group with sham RDN operation (MCT, n = 20)...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28181133/effects-of-aerobic-exercise-training-on-metabolism-of-nitric-oxide-and-endothelin-1-in-lung-parenchyma-of-rats-with-pulmonary-arterial-hypertension
#15
A Zimmer, R B Teixeira, J H P Bonetto, R Siqueira, C C Carraro, L M Donatti, A Hickmann, I E Litvin, A E G Godoy, A S Araujo, R Colombo, Adriane Belló-Klein
Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and proliferative obstruction of pulmonary vessels, which promotes a progressive increase in pulmonary vascular resistance (PVR). The effect of exercise training on oxidative stress, metabolism, and markers of nitric oxide (NO) and endothelin-1 (ET-1) was analyzed in the lung tissue of rats with PAH induced by monocrotaline (MCT).Twenty-four Wistar rats were divided into four groups (5-7 animals): sedentary control (SC), sedentary MCT (SM), trained control (TC), and trained MCT (TM)...
February 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28178911/bringing-mini-chalk-talks-to-the-bedside-to-enhance-clinical-teaching
#16
Michael B Pitt, Jay D Orlander
: Chalk talks - where the teacher is equipped solely with a writing utensil and a writing surface - have been used for centuries, yet little has been written about strategies for their use in medical education. Structured education proximal to patient encounters (during rounds, at the bedside, or in between patients in clinic) maximizes the opportunities for clinical learning. This paper presents a strategy to bring mini-chalk talks (MCTs) to the bedside as a practical way to provide relevant clinical teaching by visually framing teachable moments...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28174547/metacognitive-therapy-for-depression-in-adults-a-waiting-list-randomized-controlled-trial-with-six-months-follow-up
#17
Roger Hagen, Odin Hjemdal, Stian Solem, Leif Edward Ottesen Kennair, Hans M Nordahl, Peter Fisher, Adrian Wells
This randomized controlled trial examines the efficacy of metacognitive therapy (MCT) for depression. Thirty-nine patients with depression were randomly assigned to immediate MCT (10 sessions) or a 10-week wait list period (WL). The WL-group received 10 sessions of MCT after the waiting period. Two participants dropped out from WL and none dropped out of immediate MCT treatment. Participants receiving MCT improved significantly more than the WL group. Large controlled effect sizes were observed for both depressive (d = 2...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28168776/treatment-outcomes-and-prognostic-factors-of-feline-splenic-mast-cell-tumors-a-multi-institutional-retrospective-study-of-64-cases
#18
B J Evans, D O'Brien, S D Allstadt, T P Gregor, K U Sorenmo
BACKGROUND: Mast cell tumors (MCT) are common splenic tumors in cats, but there is limited information on treatment outcomes of cats with this disease. MATERIALS AND METHODS: This retrospective study evaluated treatment outcomes in 64 cats with splenic MCT. Cats were categorized into the following treatment groups: splenectomy (A, n = 20); splenectomy with chemotherapy (B, n = 20); chemotherapy alone (C, n = 15); or supportive care (D, n = 9). RESULTS: Median tumor specific survival (MTSS) was: 856, 853, 244, 365 days for groups A, B, C, and D, respectively...
February 7, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28166848/randomized-control-trial-to-assess-the-efficacy-of-metacognitive-training-compared-with-a-psycho-educational-group-in-people-with-a-recent-onset-psychosis
#19
S Ochoa, R López-Carrilero, M L Barrigón, E Pousa, A Barajas, E Lorente-Rovira, F González-Higueras, E Grasa, I Ruiz-Delgado, J Cid, I Birulés, I Esteban-Pinos, R Casañas, A Luengo, P Torres-Hernández, I Corripio, M Montes-Gámez, M Beltran, A De Apraiz, L Domínguez-Sánchez, E Sánchez, B Llacer, T Pélaez, J L Bogas, S Moritz
BACKGROUND: Aims were to assess the efficacy of metacognitive training (MCT) in people with a recent onset of psychosis in terms of symptoms as a primary outcome and metacognitive variables as a secondary outcome. METHOD: A multicenter, randomized, controlled clinical trial was performed. A total of 126 patients were randomized to an MCT or a psycho-educational intervention with cognitive-behavioral elements. The sample was composed of people with a recent onset of psychosis, recruited from nine public centers in Spain...
February 7, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28166421/vitamin-e-and-selenium-treatment-of-monocrotaline-induced-hepatotoxicity-in-rats
#20
G Cuce, H T Canbaz, M E Sozen, F H Yerlikaya, S Kalkan
Monocrotaline (MCT) is a hepatotoxic pyrrolizidine alkaloid that is derived from plants; exposure may occur by consumption of contaminated grains, herbal teas and medicines. MCT can cause liver damage. We investigated the antioxidant effects of selenium (Se) and vitamin E against the toxic effects of MCT. Female Wistar albino rats were divided into four groups: a control group, an MCT group, an MCT + Se group, and an MCT + vitamin E group. Liver tissues were harvested, fixed, processed to paraffin and sections were cut...
February 6, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
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