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JOURNAL ARTICLE
Xuan Song, Xin Wang, Mengxiao Yang, Alejandra Acevedo-Fani, Harjinder Singh, Aiqian Ye
There are a wide range of commercial infant formulae available on the market. These are made using milk from different species, such as goat, sheep, and cow. The different protein compositions of these milks and the process used during infant-formulae manufacture, such as heat treatment, may impact the digestion of nutrients. This study compared the effect of protein composition and heat treatment on the in vitro gastric digestion behaviour of commercial infant formulae made with cow, goat, and sheep milk using a dynamic infant human gastric simulator (IHGS)...
April 23, 2024: Foods (Basel, Switzerland)
#2
JOURNAL ARTICLE
Huiquan Zhu, Pu Zhao, Xiaodan Wang, Yunna Wang, Shuwen Zhang, Xiaoyang Pang, Jiaping Lv
We aimed to obtain the optimal formula for human milk fat substitute (HMFS) through a combination of software and an evaluation model and further verify its practicability through an animal experiment. The results showed that a total of 33 fatty acid (FA) and 63 triglyceride (TAG) molecular species were detected in vegetable oils. Palmitic acid, oleic acid, linoleic acid, 18:1/16:0/18:1, 18:2/16:0/18:2, 18:1/18:1/18:1 and 18:1/18:2/18:1, were the main molecular species among the FAs and TAGs in the vegetable oils...
May 1, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#3
JOURNAL ARTICLE
Aleksandra Purkiewicz, Renata Pietrzak-Fiećko
The quality of fat in infant milk is determined by the fatty acid profile and selected indices describing nutritional value. The aim of this study was to analyze the fatty acid profile and lipid quality indices of infant formulas and compare these data with breast milk. The study material included seven types of cow's milk-based follow-on infant formulas and samples of mature breast milk. The determination of fatty acids was performed using the gas chromatography (GC) technique. Lipid quality indices were calculated based on the relevant equations...
April 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#4
JOURNAL ARTICLE
Ning Wang, Sen Yang, Guang-Qing Mu, Fang Qian, Xue-Mei Zhu
Lipids play a pivotal role in the nutrition of preterm infants, acting as a primary energy source. Due to their underdeveloped gastrointestinal systems, lipid malabsorption is common, leading to insufficient energy intake and slowed growth. Therefore, it is critical to explore the reasons behind the low lipid absorption rate in formulas for preterm infants. This study utilized a simulated in intro gastrointestinal digestion model to assess the differences in lipid digestion between preterm human milk and various infant formulas...
June 2024: Food Research International
#5
JOURNAL ARTICLE
Martin Nørmark Thesbjerg, Ulrik Kræmer Sundekilde, Nina Aagaard Poulsen, Lotte Bach Larsen, Søren Drud-Heydary Nielsen
This study explores the disulfide bridges present in the human milk proteome by a novel approach permitting both positional identification and relative quantification of the disulfide bridges. Human milk from six donors was subjected to trypsin digestion without reduction. The digested human milk proteins were analyzed by nanoLC-timsTOF Pro combined with data analysis using xiSEARCH. A total of 85 unique disulfide bridges were identified in 25 different human milk proteins. The total relative abundance of disulfide bridge-containing peptides constituted approximately 5% of the total amount of tryptic-peptides...
May 7, 2024: Journal of Proteomics
#6
JOURNAL ARTICLE
Sarah Mess, Anna Palatnik, Erwin Cabacungan
OBJECTIVE: Antenatal breast milk expression (ABE) offers a host of benefits, including reduced formula consumption, support for breastfeeding success, and increased maternal satisfaction. Despite these advantages, experience with ABE differs significantly, often leading to anxiety over perceived inadequate milk supply and eventual breastfeeding cessation. This study comprehensively evaluates the knowledge, attitudes, and real-world experiences of individuals with gestational or pregestational diabetes concerning ABE, with a focus on total milk volume expressed prior to birth...
May 9, 2024: American Journal of Perinatology
#7
REVIEW
Lilia Delgado Paramo, Anja Bronnert, Luling Lin, Frank H Bloomfield, Mariana Muelbert, Jane E Harding
BACKGROUND: Preterm infants (born before 37 weeks' gestation) are often unable to co-ordinate sucking, swallowing, and breathing for oral feeding because of their immaturity. In such cases, initial nutrition is provided by orogastric or nasogastric tube feeding. Feeding intolerance is common and can delay attainment of full enteral and sucking feeds, prolonging the need for nutritional support and the hospital stay. Smell and taste play an important role in the activation of physiological pre-absorptive processes that contribute to food digestion and absorption...
May 9, 2024: Cochrane Database of Systematic Reviews
#8
JOURNAL ARTICLE
Min Wang, Xiaohui Gong, Lianhu Yu, Feifei Song, Dan Li, Qiaoling Fan, Ting Zhang, Xueming Yan
This study investigated the effects of exclusive donor milk or formula in the first 7 days after birth, on the time to full enteral feeding, growth, and morbidity of adverse events related to premature infants. This was a retrospective study carried out from July 2014 to December 2019 at the Department of Neonatology of Shanghai Children's Hospital. All infants with a birth weight < 1,500 g and a gestational age ≤ 32 who received exclusive donor milk or formula in the first 7 days after birth were included in this study...
2024: Frontiers in Nutrition
#9
JOURNAL ARTICLE
Christopher E Anderson, Shannon E Whaley, Michael I Goran
BACKGROUND: The Special Supplemental Nutrition Program for Women, Infants and Children (WIC) issues infant formula to infants who are not fully breastfed, and prior research found elevated obesity risk among children receiving lactose-reduced infant formula with corn syrup solids (CSSF) issued by WIC. This study was conducted to evaluate associations between a broader set of specialty infant formulas issued by WIC and child obesity risk, whether neighborhood context (e.g. neighborhood food environment) modifies associations, and whether racial/ethnic disparities in obesity are partly explained by infant formula exposure and neighborhood context...
May 8, 2024: BMC Public Health
#10
JOURNAL ARTICLE
Monique van de Lagemaat, Charlotte A Ruys, Jacqueline Muts, Martijn J J Finken, Joost Rotteveel, Johannes B van Goudoever, Harrie N Lafeber, Chris H P van den Akker
BACKGROUND: Infants born moderate-to-late preterm (i.e., 32 0 /7 -35 6 /7 weeks' gestation) are, analogous to those born very preterm, at risk of later obesity, hypertension, and diabetes. Appropriate early life nutrition is key for ensuring optimal growth and body composition, thereby mitigating potential cardiometabolic risks. OBJECTIVE: To compare growth and body composition between infants born moderate-to-late preterm fed isocaloric but protein- and mineral-enriched postdischarge formula (PDF) or standard term formula (STF) until 6 months corrected age (CA; i...
May 6, 2024: American Journal of Clinical Nutrition
#11
JOURNAL ARTICLE
Millie Barrett, Mark Spires, Christina Vogel
BACKGROUND: Healthy Start (HS) is a government scheme in England, Wales and Northern Ireland that offers a financial payment card and free vitamins to families experiencing low income. Pregnant women and families with children < 4 years can use the HS card to buy fruit, vegetables, cow's milk, infant formula and pulses. HS was fully digitalised in March 2022. While digitalisation has improved the user experience for many families, in the context of the cost-of-living crisis and increasing dietary inequalities, it is important to understand why HS is not reaching more families...
May 8, 2024: BMC Medicine
#12
JOURNAL ARTICLE
Galal Magdy, Heba Elmansi, Rasha Abo Shabana, Nahed El-Enany
The current study presents the first spectrofluorimetric approach for the estimation of lactoferrin, depending on the measurement of its native fluorescence at 337 nm after excitation at 230 nm, without the need for any hazardous chemicals or reagents. It was found that the fluorescence intensity versus concentration calibration plot was linear over the concentration range of 0.1-10.0 μg/mL with quantitation and detection limits of 0.082 and 0.027 μg/mL, respectively. The method was accordingly validated according to the ICH recommendations...
May 2024: Luminescence: the Journal of Biological and Chemical Luminescence
#13
JOURNAL ARTICLE
Sirima Sritangsirikul, Kemporn Kitsahawong, Oranart Matangkasombut, Ana Lucia Seminario, Waranuch Pitiphat
Concerns exist about prolonged breastfeeding increasing dental caries risk, but evidence is mixed. This 2-year cohort study followed 486 toddlers, to examine the association between breastfeeding duration and caries at age 3. Caregivers reported feeding practices and potential confounders every 6 months. "Full breastfeeding" was defined as feeding breastmilk without formula milk regardless of other foods/liquids, whereas "any breastfeeding" was feeding breastmilk with/without formula milk. A calibrated dentist performed dental examinations...
May 6, 2024: Scientific Reports
#14
JOURNAL ARTICLE
Antonio Bognanni, Alessandro Fiocchi, Stefania Arasi, Derek K Chu, Ignacio Ansotegui, Amal H Assa'ad, Sami L Bahna, Roberto Berni Canani, Martin Bozzola, Lamia Dahdah, Christophe Dupont, Piotr Dziechciarz, Motohiro Ebisawa, Ramon T Firmino, Alexandro Chu, Elena Galli, Andrea Horvath, Rose Kamenwa, Gideon Lack, Haiqi Li, Alberto Martelli, Anna Nowak-Węgrzyn, Nikolaos G Papadopoulos, Ruby Pawankar, Yetiani Roldan, Maria Said, Mario Sánchez-Borges, Raanan Shamir, Jonathan M Spergel, Hania Szajewska, Luigi Terracciano, Yvan Vandenplas, Carina Venter, Siw Waffenschmidt, Susan Waserman, Amena Warner, Gary W K Wong, Holger J Schünemann, Jan L Brozek
BACKGROUND: Cow's milk allergy (CMA) is the most common food allergy in infants. The replacement with specialized formulas is an established clinical approach to ensure adequate growth and minimize the risk of severe allergic reactions when breastfeeding is not possible. Still, given the availability of multiple options, such as extensively hydrolyzed cow's milk protein formula (eHF-CM), amino acid formula (AAF), hydrolyzed rice formula (HRF) and soy formulas (SF), there is some uncertainty as to the most suitable choice with respect to health outcomes...
April 2024: World Allergy Organization Journal
#15
JOURNAL ARTICLE
Tetsuhiro Sakihara, Kenta Otsuji, Yohei Arakaki, Kazuya Hamada, Shiro Sugiura, Komei Ito
BACKGROUND: Early supplementation and subsequent discontinuation of cow's milk formula (CMF) may increase the risk of cow's milk allergy in breast-fed infants, but little is known about the relationship between continuous CMF ingestion and cow's milk protein-specific immunoglobulin production. OBJECTIVE: This study aimed to clarify the aforesaid relationship in cow's milk-sensitized infants. METHODS: Using data from a randomized controlled trial of a Japanese birth cohort, we performed a subgroup analysis of participants who had ingested CMF in the first 3 days of life and exhibited a positive skin prick test response to cow's milk at age 6 months...
August 2024: J Allergy Clin Immunol Glob
#16
JOURNAL ARTICLE
Wenbo Zhang, Yingying Zhu, Hao Wang, Zhaolin Huang, Yuanlin Liu, Wei Xu, Wanmeng Mu
3'-Sialyllactose (3'-SL), one of the abundant and important sialylated human milk oligosaccharides, is an emerging food ingredient used in infant formula milk. We previously developed an efficient route for 3'-SL biosynthesis in metabolically engineered Escherichia coli BL21(DE3). Here, several promising α2,3-sialyltransferases were re-evaluated from the byproduct synthesis perspective. The α2,3-sialyltransferase from Neisseria meningitidis MC58 (NST) with great potential and the least byproducts was selected for subsequent molecular modification...
May 3, 2024: International Journal of Biological Macromolecules
#17
JOURNAL ARTICLE
Jennifer L Frueh, Peng Shu, Thomas R Vennard, Michael A Gray, Shay C Phillips
BACKGROUND: Infant formulas, pediatric and adult nutritional products are being fortified with bovine lactoferrin (bLF) due to its beneficial impacts on immune development and gut health. Lactoferrin supplementation into these products requires an analytical method to accurately quantify the concentrations of bLF to meet global regulatory and quality standards. OBJECTIVE: To develop and validate a lactoferrin method capable of meeting the AOAC Standard Method Performance Requirements (SMPR requirements 2020...
May 4, 2024: Journal of AOAC International
#18
JOURNAL ARTICLE
Kristine Holgersen, Tik Muk, Mandana Ghisari, Pankaj Arora, Anne Staudt Kvistgaard, Søren Drud-Heydary Nielsen, Per Torp Sangild, Stine Brandt Bering
BACKGROUND: β-casein is the main casein constituent in human milk (HM) and a source of bioactive peptides for the developing gastrointestinal tract and immune system. Infant formulas contain less β-casein than HM, but whether different levels of β-casein affect tolerability and gut and immune maturation in newborns is unknown. OBJECTIVE: Using near-term piglets as a model for newborn infants, we investigate whether increasing the β-casein fraction in bovine-based formula is clinically safe and may improve gut and immune maturation...
May 2, 2024: Journal of Nutrition
#19
JOURNAL ARTICLE
Sarah L Steele, Noah C A Cooke
OBJECTIVES: Commentators and professional organisations note that an expanding market in human milk-based products (HMBPs) could reduce breastfeeding, compromising maternal and infant health, and undermine public milk bank donations. We investigate whether English NHS trusts purchased these products and whether HMBP companies have marketed to them. DESIGN: Freedom of Information (FOI) requests asking: (1) whether trusts obtained human milk; (2) if so, how; and (3) whether HMBP companies had approached them...
May 2024: JRSM Open
#20
REVIEW
Vijiya Kashyap, Sonali G Choudhari
Human mother milk is considered the most healthy and best source of nutrition for both premature and full-term infants, as it possesses many health benefits and is associated with its consumption. Some of the mothers are not able to produce an adequate quantity of milk to meet the required needs of the infants, particularly in cases involving premature births or facing challenges in breastfeeding. Especially for the most vulnerable premature infants, donor human milk (DHM) provides a helpful bridge for effective breastfeeding...
April 2024: Curēus
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