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https://www.readbyqxmd.com/read/29652956/-tools-for-physical-activity-assessment-in-chronic-obstructive-pulmonary-disease
#1
Rodrigo Torres-Castro, Cristian Céspedes, Jordi Vilaró, Roberto Vera-Uribe, Marcelo Cano-Cappellacci, Diego Vargas
The prevalence and mortality of chronic obstructive pulmonary disease (COPD) is increasing in Chile, constituting a public health problem. Pulmonary and systemic consequences of COPD affect physical activity, as the disease progresses. There are multiple means for physical activity assessment, from low cost and easily applicable questionnaires to sophisticated laboratory tests. Physical inactivity is a modifiable risk factor for morbidity and mortality in patients with COPD. Physical activity interventions not only contribute to decrease the likelihood of mortality, but also protect from comorbidities, especially cardiovascular ones...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29650559/care-in-chronic-obstructive-lung-disease-carol-a-randomised-trial-in-general-practice
#2
Stefan Markun, Thomas Rosemann, Kaba Dalla-Lana, Claudia Steurer-Stey
Background: Disease management of chronic obstructive pulmonary disease (COPD) is complex and shortcomings in general practice care for COPD are common. A care bundle is a disease management aid reminding and steering specific elements of care. Objectives: To test whether a COPD care bundle delivered to general practitioners (GPs) and practice assistants (PAs) increases the implementation of key elements of COPD care. Methods: Cluster-randomised clinical trial, 1:1 randomisation of GPs, one-year follow-up. The intervention introduced a COPD care bundle and aimed at enhancing collaboration between GPs and PAs...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29643168/fatigue-in-patients-with-chronic-obstructive-pulmonary-disease-protocol-of-the-dutch-multicentre-longitudinal-observational-fantastigue-study
#3
Yvonne M J Goërtz, Milou Looijmans, Judith B Prins, Daisy J A Janssen, Melissa S Y Thong, Jeannette B Peters, Chris Burtin, Yvonne Meertens-Kerris, Arnold Coors, Jean W M Muris, Mirjam A G Sprangers, Emiel F M Wouters, Jan H Vercoulen, Martijn A Spruit
INTRODUCTION: Fatigue is the second most common symptom in patients with chronic obstructive pulmonary disease (COPD). Despite its high prevalence, fatigue is often ignored in daily practice. For this reason, little is known about the underlying determinants of fatigue in patients with COPD. The primary objectives of this study are to chart the course of fatigue in patients with COPD, to identify the physical, systemic, psychological and behavioural factors that precipitate and perpetuate fatigue in patients with COPD, to evaluate the impact of exacerbation-related hospitalisations on fatigue and to better understand the association between fatigue and 2-year all-cause hospitalisation and mortality in patients with COPD...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29642882/assessing-the-healthcare-resource-use-associated-with-inappropriate-prescribing-of-inhaled-corticosteroids-for-people-with-chronic-obstructive-pulmonary-disease-copd-in-gold-groups-a-or-b-an-observational-study-using-the-clinical-practice-research-datalink
#4
James D Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson, Alicia Gayle
BACKGROUND: Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencing exacerbations (≥ 2 or ≥ 1 requiring hospitalisation); i.e. GOLD groups C and D. However, it is known that ICS is frequently prescribed for patients with less severe COPD. Potential drivers of inappropriate ICS use may be historical clinical guidance or a belief among physicians that intervening early with ICS would improve outcomes and reduce resource use...
April 11, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29625777/tai-chi-and-pulmonary-rehabilitation-compared-for-treatment-naive-patients-with-copd-a-randomized-controlled-trial
#5
Michael I Polkey, Zhi-Hui Qiu, Lian Zhou, Meng-Duo Zhu, Ying-Xin Wu, Yong-Yi Chen, Sheng-Peng Ye, Yu-Shan He, Mei Jiang, Bai-Ting He, Bhavin Mehta, Nan-Shan Zhong, Yuan-Ming Luo
BACKGROUND: In COPD, functional status is improved by pulmonary rehabilitation (PR) but requires specific facilities. Tai Chi, which combines psychological treatment and physical exercise and requires no special equipment, is widely practiced in China and is becoming increasingly popular in the rest of the world. We hypothesized that Tai Chi is equivalent (ie, difference less than ±4 St. George's Respiratory Questionnaire [SGRQ] points) to PR. METHODS: A total of 120 patients (mean FEV1 , 1...
March 28, 2018: Chest
https://www.readbyqxmd.com/read/29581202/real-world-effects-of-medications-for-chronic-obstructive-pulmonary-disease-protocol-for-a-uk-population-based-non-interventional-cohort-study-with-validation-against-randomised-trial-results
#6
Kevin Wing, Elizabeth Williamson, James R Carpenter, Lesley Wise, Sebastian Schneeweiss, Liam Smeeth, Jennifer K Quint, Ian Douglas
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a progressive disease affecting 3 million people in the UK, in which patients exhibit airflow obstruction that is not fully reversible. COPD treatment guidelines are largely informed by randomised controlled trial results, but it is unclear if these findings apply to large patient populations not studied in trials. Non-interventional studies could be used to study patient groups excluded from trials, but the use of these studies to estimate treatment effectiveness is in its infancy...
March 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29575948/blood-biomarkers-in-chronic-airways-diseases-and-their-role-in-diagnosis-and-management
#7
Job J M H van Bragt, Susanne J H Vijverberg, Els J M Weersink, Levi B Richards, Anne H Neerincx, Peter J Sterk, Elisabeth H D Bel, Anke H Maitland-van der Zee
The complexity and heterogeneous nature of asthma and chronic obstructive pulmonary disease (COPD) results in difficulties in diagnosing and treating patients. Biomarkers that can identify underlying mechanisms, identify patient phenotypes and to predict treatment response could be of great value for adequate treatment. Areas covered: Biomarkers play an important role for the development of novel targeted therapies in airways disease. Blood biomarkers are relatively non-invasive, easy to obtain and easy to apply in routine care...
March 29, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29572448/improvement-in-the-management-of-chronic-obstructive-pulmonary-disease-following-a-clinical-educational-program-results-from-a-prospective-cohort-study-in-the-sicilian-general-practice-setting
#8
Rosarita Ferrara, Valentina Ientile, Carlo Piccinni, Alessandro Pasqua, Serena Pecchioli, Andrea Fontana, Umberto Alecci, Riccardo Scoglio, Francesco Magliozzo, Sebastiano Emanuele Torrisi, Carlo Vancheri, Patrizio Vitulo, Giovanna Fantaci, Carmen Ferrajolo, Mario Cazzola, Claudio Cricelli, Achille Patrizio Caputi, Gianluca Trifirò
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lungs associated with progressive disability. Although general practitioners (GPs) should play an important role in the COPD management, critical issues have been documented in the primary care setting. The aim of this study was to evaluate the effectiveness of an educational program for the improvement of the COPD management in a Sicilian general practice setting. The effectiveness of the program, was evaluated by comparing 15 quality-of-care indicators developed from data extracted by 33 GPs, at baseline vs...
March 23, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29568852/ministry-of-health-clinical-practice-guidelines-chronic-obstructive-pulmonary-disease
#9
Tow Keang Lim, Cynthia B Chee, Patsy Chow, Gerald Sw Chua, Soo Kiang Eng, Soon Keng Goh, Kwee Keng Kng, Wai Hing Lim, Tze Pin Ng, Thun How Ong, S T Angeline Seah, Hsien Yung Tan, K H Tee, Vimal Palanichamy, Meredith T Yeung
The Ministry of Health (MOH) has updated the Clinical Practice Guidelines on Chronic Obstructive Pulmonary Disease (COPD) to provide doctors and patients in Singapore with evidence-based treatment for COPD. This article reproduces the introduction and executive summary (with recommendations from the guidelines) from the MOH Clinical Practice Guidelines on COPD, for the information of SMJ readers. Chapters and page numbers mentioned in the reproduced extract refer to the full text of the guidelines, which are available from the Ministry of Health website: https://www...
February 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29564639/real-world-heart-failure-management-in-10-910-patients-with-chronic-heart-failure-in-the-netherlands-design-and-rationale-of-the-chronic-heart-failure-esc-guideline-based-cardiology-practice-quality-project-check-hf-registry
#10
J J Brugts, G C M Linssen, A W Hoes, H P Brunner-La Rocca
AIMS: Data from patient registries give insight into the management of patients with heart failure (HF), but actual data from unselected real-world HF patients are scarce. Therefore, we performed a cross sectional study of current HF care in the period 2013-2016 among more than 10,000 unselected HF patients at HF outpatient clinics in the Netherlands. METHODS: In 34 participating centres, all 10,910 patients with chronic HF treated at cardiology centres were included in the CHECK-HF registry...
March 21, 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29559183/usefulness-of-simple-biomarkers-at-admission-as-independent-indicators-and-predictors-of-in-hospital-mortality-in-older-hip-fracture-patients
#11
Alexander Fisher, Leon Fisher, Wichat Srikusalanukul, Paul N Smith
INTRODUCTION: The data on predictive value of the routinely obtained preoperative biochemical parameters in hip fracture (HF) patients are limited. The aims of this study were to examine in older HF patients (1) the relationships between a broad set of routine laboratory parameters at admission and in-hospital mortality, and (2) evaluate the prognostic value the biomarkers and clinical characteristics (alone or in combination) provide to predict a fatal outcome. PATIENTS AND METHODS: In 1820 consecutive patients with low-trauma osteoporotic HF aged >60 years (mean age 82...
March 8, 2018: Injury
https://www.readbyqxmd.com/read/29558236/demographic-and-clinical-characteristics-of-copd-patients-at-different-blood-eosinophil-levels-in-the-uk-clinical-practice-research-datalink
#12
Sarah Landis, Robert Suruki, Joe Maskell, Kerina Bonar, Emma Hilton, Chris Compton
Blood eosinophil count may be a useful biomarker for predicting response to inhaled corticosteroids and exacerbation risk in chronic obstructive pulmonary disease (COPD) patients. The optimal cut point for categorizing blood eosinophil counts in these contexts remains unclear. We aimed to determine the distribution of blood eosinophil count in COPD patients and matched non-COPD controls, and to describe demographic and clinical characteristics at different cut points. We identified COPD patients within the UK Clinical Practice Research Database aged ≥40 years with a FEV1 /FVC <0...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29558226/management-of-copd-in-end-of-life-care-by-spanish-pulmonologists
#13
Patricia Sobradillo Ecenarro, Marta Inchausti Iguiñiz, Sandra Pedrero Tejada, Nuria Marina Malanda, María Alfonso Imizcoz, Laura Ansola Marlasca, Bernardino Alcázar Navarrete
Chronic obstructive pulmonary disease is progressive and in its advanced stage is associated with major disability. Previous studies suggest that patients with this disease receive little palliative care, even in very advanced stages. Given this, our objectives were to describe the clinical practice of Spanish pulmonologists in the care of patients with end-stage chronic obstructive pulmonary disease, to identify potential barriers to implementing palliative care in these patients and to correlate these responses with doctor's years of experience...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29558165/current-approaches-for-phenotyping-as-a-target-for-precision-medicine-in-copd-management
#14
Jose Luis Lopez-Campos, Stefano Centanni
The study of airway diseases continues to present several challenges for modern medicine. The different disease presentations with variables and overlapping features may result in a real challenge for the clinician. In this context, the concept of precision medicine has started to emerge in order to give answers to some of these challenges from a diagnostic and therapeutic point of view. The main reasons to target for precision medicine in chronic obstructive pulmonary disease (COPD) include that there is variability in the clinical presentation, there is no correlation between the different clinical variables at the patient level, there are a number of relevant clinical variables associated with outcomes, we do have specific therapies for specific patient types, and that there is variability in the clinical response to different therapies...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29553450/management-of-chronic-obstructive-pulmonary-disease-exacerbations-at-the-nasser-medical-complex-a-clinical-audit
#15
Maha Al-Faqawi, Yousef Abuowda, Alaa Eldeen Elmassry, Bettina Böttcher
BACKGROUND: The frequency and severity of chronic obstructive pulmonary disease (COPD) exacerbations are the most important determinants of prognosis in COPD. The aim of this study was to assess the management of patients presenting with COPD exacerbations at the Nasser Medical Complex in the Gaza Strip and to compare the management with the Global Initiative for Chronic Obstructive Lung Disease guidelines (GOLD 2015). METHODS: We reviewed the medical records of all patients admitted to Nasser Medical Complex and diagnosed with COPD exacerbation between Jan 1, 2014, and Dec 31, 2016...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29550368/asthma-and-copd-overlap-pathophysiology-of-aco
#16
REVIEW
Mari Hikichi, Shu Hashimoto, Yasuhiro Gon
Asthma and COPD appear as a result of different mechanisms triggered by different pathogeneses and although they present different features and symptoms of airway inflammation and airway obstruction, there are also cases that present the features of both asthma and COPD. This type of pathology is known as asthma-COPD overlap syndrome (ACOS). Asthma-COPD overlap is identified in clinical practice by the features that it shares with both asthma and COPD. This is not a definition, but a description for clinical use, as asthma-COPD overlap includes several different clinical phenotypes and there are likely to be several different underlying mechanisms"...
March 14, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29548802/creation-of-the-saq-copd-questionnaire-to-determine-physical-activity-in-copd-patients-in-clinical-practice
#17
Juan José Soler-Cataluña, Luis Puente Maestu, Miguel Román-Rodríguez, Cristóbal Esteban, Joaquín Gea, Roberto Bernabeu Mora, Eulogio Pleguezuelos Cobo, Julio Ancochea, Gema Monteagudo Ruiz, Francisco Garcia Rio
INTRODUCTION: Physical activity (PA) is a significant clinical dimension in COPD, but no useful tools are available to determine this variable in routine clinical practice. OBJECTIVE: To create a simple, easy-to-use, specific questionnaire to detect PA deficits. METHOD: A multidisciplinary panel of COPD experts was formed to review PA, its determinants, and measuring methods. The methodology for selecting specific dimensions and items was agreed in rounds, and the aspects to be included in the preliminary version were determined...
March 13, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29516853/the-feasibility-of-early-pulmonary-rehabilitation-and-activity-after-copd-exacerbations-external-pilot-randomised-controlled-trial-qualitative-case-study-and-exploratory-economic-evaluation
#18
Matthew Cox, Catherine O'Connor, Katie Biggs, Daniel Hind, Oscar Bortolami, Matthew Franklin, Barbara Collins, Stephen Walters, Allan Wailoo, Julie Channell, Paul Albert, Ursula Freeman, Stephen Bourke, Michael Steiner, Jon Miles, Tom O'Brien, David McWilliams, Terry Schofield, John O'Reilly, Rodney Hughes
BACKGROUND: Chronic obstructive pulmonary disease (COPD) affects > 3 million people in the UK. Acute exacerbations of COPD (AECOPD) are the second most common reason for emergency hospital admission in the UK. Pulmonary rehabilitation is usual care for stable COPD but there is little evidence for early pulmonary rehabilitation (EPR) following AECOPD, either in hospital or immediately post discharge. OBJECTIVE: To assess the feasibility of recruiting patients, collecting data and delivering EPR to patients with AECOPD to evaluate EPR compared with usual care...
March 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29512869/cardiovascular-diseases-may-play-a-negative-role-in-the-prognosis-of-als
#19
Jessica Mandrioli, Laura Ferri, Antonio Fasano, Elisabetta Zucchi, Nicola Fini, Cristina Moglia, Christian Lunetta, Kalliopi Marinou, Nicola Ticozzi, Gianluca Drago Ferrante, Carlo Scialo, Gianni Sorarù, Francesca Trojsi, Amelia Conte, Yuri M Falzone, Rosanna Tortelli, Massimo Russo, Valeria Ada Sansone, Gabriele Mora, Vincenzo Silani, Paolo Volanti, Claudia Caponnetto, Giorgia Querin, Maria Rosaria Monsurrò, Mario Sabatelli, Adriano Chiò, Nilo Riva, Giancarlo Logroscino, Sonia Messina, Andrea Calvo
BACKGROUND: Only a few studies considered the role of comorbidities on ALS prognosis and provided conflicting results. METHODS: our multicenter, retrospective study included patients diagnosed from 1/1/2009 to 31/12/2013 in 13 Referral Centers for ALS located in 10 Italian Regions. Caring neurologists collected a detailed phenotypic profile and follow-up data until death into an electronic database. Comorbidities at diagnosis were recorded by main categories and single medical diagnosis, with the aim of investigating their role on ALS prognosis...
March 7, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29505318/a-safety-comparison-of-laba-lama-vs-laba-ics-combination-therapy-for-copd
#20
Maria Gabriella Matera, Luigino Calzetta, Ermanno Puxeddu, Paola Rogliani, Mario Cazzola
LABA+LAMA and LABA+ICS combinations are key pharmacological approaches to the treatment of COPD. However, both combination types can induce adverse events (AEs). Areas covered: Current literature on LABA+LAMA and LABA+ICS combinations has been reviewed with a specific focus on their safety profile in the treatment of COPD. Expert opinion: Several meta-analyses have compared the pooled safety data from randomized clinical trials (RCTs) of LABA+LAMA combinations with LABA+ICS combinations. LABA+LAMA caused significantly less AEs and SAEs...
March 8, 2018: Expert Opinion on Drug Safety
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