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exacerbation of copd

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https://www.readbyqxmd.com/read/29915333/impact-of-bronchiectasis-on-outcomes-of-hospitalized-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-a-propensity-matched-analysis
#1
Ernesto Crisafulli, Mónica Guerrero, Antonella Ielpo, Adrian Ceccato, Arturo Huerta, Albert Gabarrús, Néstor Soler, Alfredo Chetta, Antoni Torres
The coexistence of both Chronic Obstructive Pulmonary Disease (COPD) and bronchiectasis (BE) define an emerging phenotype with a worse prognosis; however, data about these patients do not consider baseline characteristics as confounders. We evaluate the impact of BE on outcomes of hospitalized patients with acute exacerbation of COPD (AECOPD). We prospectively considered AECOPD patients, analysed using a propensity score matching (PSM) method. The outcomes included length of hospital stay, use of non-invasive and invasive mechanical ventilation, intensive care unit admission, and mortality up to 3-years...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29915220/predicta-chip-based-high-resolution-diagnosis-of-rhinovirus-induced-wheeze
#2
Katarzyna Niespodziana, Katarina Stenberg-Hammar, Spyridon Megremis, Clarissa R Cabauatan, Kamila Napora-Wijata, Phyllis C Vacal, Daniela Gallerano, Christian Lupinek, Daniel Ebner, Thomas Schlederer, Christian Harwanegg, Cilla Söderhäll, Marianne van Hage, Gunilla Hedlin, Nikolaos G Papadopoulos, Rudolf Valenta
Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of virus type-specific treatment strategies. Here, we develop a chip containing 130 different micro-arrayed RV proteins and peptides and demonstrate in a cohort of 120 pre-school children, most of whom had been hospitalized due to acute wheeze, that it is possible to determine the culprit RV species with a minute blood sample by serology...
June 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29914609/identification-of-chronic-obstructive-pulmonary-disease-subgroups-in-13-asian-cities
#3
W J Kim, V Gupta, M Nishimura, H Makita, L Idolor, C Roa, L-C Loh, C-K Ong, J-S Wang, W Boonsawat, K D Gunasekera, D Madegedara, H-P Kuo, C-H Wang, C Wang, T Yang, Y-X Lin, F W S Ko, D S C Hui, L T T Lan, Q T T Vu, A B Bhome, A Ng, J B Seo, B Y Lee, J S Lee, Y-M Oh, S-D Lee
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition that can differ in its clinical manifestation, structural changes and response to treatment. OBJECTIVE: To identify subgroups of COPD with distinct phenotypes, evaluate the distribution of phenotypes in four related regions and calculate the 1-year change in lung function and quality of life according to subgroup. METHODS: Using clinical characteristics, we performed factor analysis and hierarchical cluster analysis in a cohort of 1676 COPD patients from 13 Asian cities...
July 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29912841/time-varying-readmission-diagnoses-during-30-days-after-hospitalization-for-copd-exacerbation
#4
Tadahiro Goto, Mohammad K Faridi, Carlos A Camargo, Kohei Hasegawa
OBJECTIVE: To investigate the longitudinal changes in principal readmission diagnoses within 30 days after hospitalization for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). STUDY SETTING: Medicare claims data, 2010-2012. STUDY DESIGN: Retrospective cohort study. DATA COLLECTION METHODS: We identified AECOPD hospitalizations aged 65 years and above, and examined the principal 30-day readmission diagnoses (respiratory related, cardiac related, and other conditions)...
June 15, 2018: Medical Care
https://www.readbyqxmd.com/read/29912647/the-association-between-local-meteorological-changes-and-exacerbation-of-acute-wheezing-in-kandy-sri-lanka
#5
N D B Ehelepola, Kusalika Ariyaratne, Amithe Jayaratne
BACKGROUND: Severe wheezing is a common medical emergency. Past studies have demonstrated associations between exacerbation of wheezing and meteorological factors and atmospheric pollution. There are no past studies from Sri Lanka that analyzed correlation between daily multiple meteorological variables and exacerbation of wheezing. OBJECTIVES: To determine the correlations between daily counts of patients nebulized at the Outpatient Department (OPD) of Teaching Hospital - Kandy (THK) and local meteorological variables, and to explore the utility of that information...
2018: Global Health Action
https://www.readbyqxmd.com/read/29908152/reducing-readmissions-in-patients-with-both-heart-failure-and-chronic-obstructive-pulmonary-disease
#6
REVIEW
Ravi Kalhan, R Kannan Mutharasan
Patients with both chronic obstructive pulmonary disease (COPD) and heart failure (HF) pose particularly high costs to the healthcare system. These diseases arise from similar root causes, have overlapping symptoms, and share similar clinical courses. Because of these strong parallels, strategies to reduce readmissions in patients with both conditions share synergies. Here we present 10 practical tips to reduce readmissions in this challenging population. 1: Diagnose the population accurately. 2: Detect admissions for exacerbations early and consider risk-stratification...
June 13, 2018: Chest
https://www.readbyqxmd.com/read/29907272/noninvasive-options
#7
REVIEW
Giuseppe Bello, Alessandra Ionescu Maddalena, Valentina Giammatteo, Massimo Antonelli
Noninvasive ventilation (NIV) has assumed a central role in the treatment of selected patients with acute respiratory failure due to exacerbated chronic obstructive pulmonary disease or acute cardiogenic pulmonary edema. Recent advances in the understanding of physiologic aspects of NIV application through different interfaces and ventilator settings have led to improved patient-machine interaction, enhancing favorable NIV outcome. In recent years, the growing role of NIV in the acute care setting has led to the development of technical innovations to overcome the problems related to gas leakage and dead space, improving the quality of the devices and optimizing ventilation modes...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907113/microorganisms-resistant-to-conventional-antimicrobials-in-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#8
Cristina Estirado, Adrian Ceccato, Monica Guerrero, Arturo Huerta, Catia Cilloniz, Olivia Vilaró, Albert Gabarrús, Joaquim Gea, Ernesto Crisafulli, Nestor Soler, Antoni Torres
BACKGROUND: Antimicrobial treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains controversial. In some cases AECOPD are caused by microorganisms that are resistant to treatments recommended by guidelines. Our aims were: 1) identify the risk factors associated with infection by microorganisms resistant to conventional treatment (MRCT), 2) Compare the clinical characteristics and outcomes of patients with AECOPD resulting from MRCT against those with AECOPD from other causes...
June 15, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29906247/a-critical-role-for-abc-transporters-in-persistent-lung-inflammation-in-the-development-of-emphysema-after-smoke-exposure
#9
Jarrod Sonett, Monica Goldklang, Piotr Sklepkiewicz, Adam Gerber, Jordis Trischler, Tina Zelonina, Marit Westerterp, Vincent Lemaître, Yasunori Okada, Jeanine D'Armiento
Macrophage infiltration is common to both emphysema and atherosclerosis, and cigarette smoke down-regulates the macrophage cholesterol efflux transporter ATP binding cassette (ABC)A1. This decreased cholesterol efflux results in lipid-laden macrophages. We hypothesize that cigarette smoke adversely affects cholesterol transport via an ABCA1-dependent mechanism in macrophages, enhancing TLR4/myeloid differentiation primary response gene 88 (Myd88) signaling and resulting in matrix metalloproteinase (MMP) up-regulation and exacerbation of pulmonary inflammation...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29904438/the-use-of-serum-procalcitonin-as-a-diagnostic-and-prognostic-biomarker-in-chronic-obstructive-pulmonary-disease-exacerbations-a-literature-review-update
#10
REVIEW
Nikolaos-Dimitrios Pantzaris, Diamantina-Xanthi Spilioti, Aikaterini Psaromyalou, Ioanna Koniari, Dimitrios Velissaris
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major complication in COPD patients which can be triggered by bacterial or viral infections, environmental pollutants and other causes. Procalcitonin (PCT), a peptide that markedly increases in cases of bacterial infection, has been extensively investigated as a biomarker in the diagnosis, prognosis and treatment in patients with AECOPD. A number of studies published in the last decade, tried to investigate whether PCT levels can differentiate between bacterial and other causes of exacerbations, if they can be used as a guide for optimal antibiotic therapy and if they can be a tool in the assessment of the severity and the need for further interventions in the management of those patients...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904014/is-it-time-to-change-the-definition-of-acute-exacerbation-of-chronic-obstructive-pulmornary-disease-what-do-we-need-to-add
#11
REVIEW
Maria Montes de Oca, Maria Eugenia Laucho-Contreras
Acute exacerbations in chronic obstructive pulmonary disease (AECOPD) are associated with increased mortality, rate of hospitalization, use of healthcare resources, and have a negative impact on disease progression, quality of life and lung function of patients with chronic obstructive pulmonary disease (COPD). There is an imperative need to homogenize the definition of AECOPD because the incidence of exacerbations has a significant influence or implication on treatment decision making, particularly in pharmacotherapy and could impact the outcome or change the statistical significance of a therapeutic intervention in clinical trials...
June 14, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29903700/feasibility-of-using-a-smartwatch-to-intensively-monitor-patients-with-chronic-obstructive-pulmonary-disease-prospective-cohort-study
#12
Robert Wu, Daniyal Liaqat, Eyal de Lara, Tatiana Son, Frank Rudzicz, Hisham Alshaer, Pegah Abed-Esfahani, Andrea S Gershon
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated decline in lung function, diminished quality of life, and higher mortality. Proactively monitoring patients for early signs of an exacerbation and treating them early could prevent these outcomes. The emergence of affordable wearable technology allows for nearly continuous monitoring of heart rate and physical activity as well as recording of audio which can detect features such as coughing...
June 14, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29901534/risk-factors-for-loss-of-lung-sliding-in-a-medical-intensive-care-population-with-acute-respiratory-failure
#13
Christopher Mallow, Warren Isakow
BACKGROUND: Point of care bedside ultrasound is widely utilized as a rapid technique to evaluate patients with acute pulmonary emergencies, including acute pneumothorax. The presence of a pneumothorax is a known cause of loss of lung sliding by ultrasound examination, but no other risk factors have been clearly identified. We attempted to identify demographic and patient characteristics that are risk factors for loss of ultrasonographic lung sliding in the absence of a pneumothorax. METHODS: Data were collected on 159 patients admitted to the medical intensive care unit with acute respiratory failure, undergoing routine admission lung ultrasound...
June 12, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29892192/increased-urinary-l-histidine-in-patients-with-asthma-copd-overlap-a-pilot-study
#14
Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Kyung Ho Kang, Chin Kook Rhee, Seoung Ju Park, Adnan Khan, Jinhyuk Na, Youngja H Park, Jae Jeong Shim
Purpose: Asthma-COPD overlap (ACO) is heterogeneous in nature and requires a unified diagnostic approach. We investigated the urinary levels of l-histidine, a precursor of histamine related to inflammatory responses, as a new candidate biomarker for diagnosing this condition. Patients and methods: We performed a prospective multicenter cohort study with retrospective analysis of 107 patients, who were divided into three groups: asthma, COPD, and ACO, according to the Spanish guidelines algorithm...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29890705/shall-we-focus-on-the-eosinophil-to-guide-treatment-with-systemic-corticosteroids-during-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-copd-con
#15
REVIEW
Pedro J Marcos, José Luis López-Campos
The employment of systemic corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD) has been shown to improve airway limitation, decrease treatment failure and risk of relapse, and may improve symptoms in addition to decreasing the length of hospital stay. Nowadays, all clinical guidelines recommend systemic corticosteroids to treat moderate or severe COPD exacerbations. However, their use is associated with potential side effects, mainly hyperglycemia. In the era of precision medicine, the possibility of employing blood eosinophil count has emerged as a potential way of optimizing therapy...
June 8, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29887758/expansion-of-a-population-of-large-monocytes-atypical-monocytes-in-peripheral-blood-of-patients-with-acute-exacerbations-of-chronic-obstructive-pulmonary-diseases
#16
Jing Yang, Man Qiao, Yanxia Li, Guohua Hu, Chunxia Song, Liping Xue, Hong Bai, Jie Yang, Xi Yang
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is closely associated with airway inflammation including monocytes, lymphocytes, and neutrophils. Monocytes play an essential role in the pathogenesis of chronic obstructive pulmonary disease (COPD). To elucidate the association of circulating monocyte alteration with AECOPD, we analyzed monocyte subpopulation in the peripheral blood of 16 healthy volunteers and 22 AECOPD patients at the stages of admission and remission after clinical therapy...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29887234/a-pilot-study-of-daily-telemonitoring-to-predict-acute-exacerbation-in-chronic-obstructive-pulmonary-disease
#17
Joanna Miłkowska-Dymanowska, Adam J Białas, Waldemar Obrębski, Paweł Górski, Wojciech J Piotrowski
BACKGROUND: Exacerbations of COPD (ECOPD) are important events in the course of COPD and they accelerate the rate of decline of lung function, and exacerbations requiring hospitalization are associated with significant mortality. Therefore, developing approaches of prevention and early treatment of ECOPDs are of special clinical interests. One of such approaches is telecare, including home telemonitoring. MATERIAL AND METHODS: Daily telemonitoring of HR, BP, SpO2 and spirometry was performed...
August 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29884817/corticosteroid-suppression-of-antiviral-immunity-increases-bacterial-loads-and-mucus-production-in-copd-exacerbations
#18
Aran Singanayagam, Nicholas Glanville, Jason L Girkin, Yee Man Ching, Andrea Marcellini, James D Porter, Marie Toussaint, Ross P Walton, Lydia J Finney, Julia Aniscenko, Jie Zhu, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Chris Grainge, Su-Ling Loo, Punnam Chander Veerati, Prabuddha S Pathinayake, Kristy S Nichol, Andrew T Reid, Phillip L James, Roberto Solari, Peter A B Wark, Darryl A Knight, Miriam F Moffatt, William O Cookson, Michael R Edwards, Patrick Mallia, Nathan W Bartlett, Sebastian L Johnston
Inhaled corticosteroids (ICS) have limited efficacy in reducing chronic obstructive pulmonary disease (COPD) exacerbations and increase pneumonia risk, through unknown mechanisms. Rhinoviruses precipitate most exacerbations and increase susceptibility to secondary bacterial infections. Here, we show that the ICS fluticasone propionate (FP) impairs innate and acquired antiviral immune responses leading to delayed virus clearance and previously unrecognised adverse effects of enhanced mucus, impaired antimicrobial peptide secretion and increased pulmonary bacterial load during virus-induced exacerbations...
June 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29884255/copd-home-oxygen-therapy-and-home-mechanical-ventilation-improving-admission-free-survival-in-persistent-hypercapnic-copd
#19
Gerard J Criner, Michael Dreher, Nicholas Hart, Patrick Murphy
As seen in this CME online activity (available at http://journal.cme.chestnet.org/copd-hot-hmv), acute exacerbations of COPD are associated with significant levels of morbidity and mortality. Acute noninvasive ventilation has been demonstrated its clinical efficacy and cost-effectiveness in reducing intubation rate and mortality and in patients with acute decompensated hypercapnic exacerbations of COPD. However, those patients with evidence of chronic hypercapnic respiratory failure have worse long-term outcomes compared with patients who have only transient hypercapnia during the acute phase returning to eucapnia in the recovery stage...
June 2018: Chest
https://www.readbyqxmd.com/read/29884254/copd-advanced-patient-management
#20
Gerard J Criner, Michael Dreher, Carolyn M D'Ambrosio, Richard Zuwallack, Jens Geiseler, Jean Louis Pépin
COPD is the third leading cause of death in the United States, with current rates of both morbidity and mortality persisting and contributing significantly to long-term disability. More than 11 million Americans are diagnosed with COPD, with an additional 13 million people estimated to be living with undiagnosed disease. For patients diagnosed with COPD, the turning point will be hospitalization. It is important, therefore, that new treatment techniques that manage the signs and symptoms of the COPD and impact the prevalence and severity of exacerbations, hospital admissions, quality of life, and activities of daily living, and innovative clinical management strategies that optimize hospital discharge planning, all show promise in improving outcomes for patients with COPD...
June 2018: Chest
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