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Pan Hu, Liming Zhao, Huilin Zhang, Xiuchun Yu, Zhen Wang, Zhaoming Ye, Sujia Wu, Shibing Guo, Guochuan Zhang, Jinghua Wang, Xianjia Ning, Yongcheng Hu, Yingze Zhang
Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23...
November 9, 2016: Scientific Reports
Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino, Joseph S Bednash, Yingze Zhang, Bryan J McVerry, Yuan Liu, Bill B Chen
Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through the ubiquitination and degradation of the receptor in response to ligand stimulation. We show a new mechanism in which an uncharacterized RING finger E3 ligase, PPP1R11, directly ubiquitinates TLR2 both in vitro and in vivo, which leads to TLR2 degradation and disruption of the signaling cascade...
November 2, 2016: ELife
Na Liu, Ruixiang Qu, Yuning Chen, Yingze Cao, Weifeng Zhang, Xin Lin, Yen Wei, Lin Feng, Lei Jiang
Dual purification of both oily wastewater and dye-polluted water for enhancing the use of freshwater is an urgent task. We report herein, the facile synthesis of inorganic semiconductor nanomaterials anchored mesh for in situ dual-functional water purification. This resultant mesh combines the excellent capacity of oil removal and the advantage of photocatalytic performance for dye degradation under visible light irradiation at the same time. In addition, the mesh was easily regenerated and remained unaltered in photocatalytic performance over five successive dye degradation cycles...
October 26, 2016: Nanoscale
Yingze Wei, Danyang Liu, Xiaoxia Jin, Pan Gao, Qingying Wang, Jiawen Zhang, Nong Zhang
Acquired resistance to doxorubicin in breast cancer is a serious therapeutic problem. In this study, we investigated whether Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) could inhibit the growth of doxorubicin-resistant breast cancer cells. We found that the expressions of Nrf2 and p62 in breast cancer were higher than that in the corresponding adjacent normal tissues and benign breast epithelial cell. The expressions of Nrf2 and p62 in breast cancer doxorubicin-resistant cells MCF-7/ADR were higher than that in doxorubicin-sensitive cells MCF-7...
October 18, 2016: Cancer Medicine
Shibing Yu, Laura M Yerges-Armstrong, Yanxia Chu, Joseph M Zmuda, Yingze Zhang
The wingless pathway has a powerful influence on bone metabolism and is a therapeutic target in skeletal disorders. Wingless signaling is mediated in part through the Frizzled (FZD) receptor family. FZD transcriptional regulation is poorly understood. Herein we tested the hypothesis that Sp1 plays an important role in the transcriptional regulation of FZD1 expression in osteoblasts and osteoblast mineralization. To test this hypothesis, we conducted FZD1 promoter assays in Saos2 cells with and without Sp1 overexpression...
2016: PloS One
Yuning Chen, Na Liu, Yingze Cao, Xin Lin, Liangxin Xu, Weifeng Zhang, Yen Wei, Lin Feng
A superhydrophilic and underwater superoleophobic surface is fabricated by simply coating silica nanospheres onto a glass fiber membrane through a sol-gel process. Such membrane has a complex framework with micro and nano structures covering and presents a high efficiency (more than 98%) of oil-in-water emulsion separation under harsh environments including strong acidic and concentrated salty conditions. This membrane also possesses outstanding stability since no obvious decline in efficiency is observed after different kinds of oil-in-water emulsions separation, which provides it candidate for comprehensive applicability...
2016: Scientific Reports
Danyang Liu, Yonglong Zhang, Yingze Wei, Guoyuan Liu, Yufeng Liu, Qiongmei Gao, Liping Zou, Wenjiao Zeng, Nong Zhang
Nuclear factor erythroid-2-related factor 2 (Nrf2), a master transcription factor in the antioxidant response, has been found to be ubiquitously expressed in various cancer cells and in the regulation tumor proliferation, invasion, and chemoresistance activities. The regulatory roles of Nrf2 in controlling Hepatocellular carcinoma (HCC) progression remain unclear. In this study, we demonstrated that Nrf2 was significantly elevated in HCC cells and tissues and was correlated with poor prognosis of HCCs. Consistently, Nrf2 significantly promoted HCC cell growth both in vitro and in vivo...
August 30, 2016: Oncotarget
Kunlun Yu, Xinzhong Shao, Dehu Tian, Jiangbo Bai, Bing Zhang, Yingze Zhang
The aim of the present study was to treat intraosseous ganglia of the carpal bones with injectable bone cement grafting. Between January 2012 and December 2013, 4 patients (3 men and 1 woman) presenting with wrist pain and activity limitation were diagnosed with intraosseous ganglion of the carpal bones by radiography. The patients were treated with minimal invasive curettage and bone cement injection surgery. All patients were followed up for a mean time of 17 months (range, 12-22 months). The wrist pain was significantly reduced in all patients following surgery...
September 2016: Experimental and Therapeutic Medicine
Weifeng Zhang, Na Liu, Yingze Cao, Yuning Chen, Qingdong Zhang, Xin Lin, Ruixiang Qu, Haifang Li, Lin Feng
Aiming to solve the worldwide challenge of stabilized oil-in-water emulsion separation, a PAM-PDVB decorated nylon membrane is fabricated via a facile solvothermal route in our group. The main composition is PAM, while the PDVB plays a role as cross-linker in order to improve the interaction between the polymer and the substrate. By the combination of the superhydrophilic and underwater superoleophobic wettability of the PAM polymer with the micropore size of the substrate, the as-prepared material is able to achieve the separation of various stabilized oil-in-water emulsions including cationic type, nonionic type, and anionic type...
August 24, 2016: ACS Applied Materials & Interfaces
Helin Feng, Jin Wang, Jianfa Xu, Wei Chen, Yingze Zhang
Review current treatments of metastatic lesions in the proximal femur.We reviewed published literature related to diagnosis and surgical treatments and summarized current treatment options.Surgical management mainly consist of internal fixation, hip replacement, and percutaneous femoroplasty (PFP) which has been newly applied in clinical practice.An appropriate series of treatments is necessary for patients to avoid the occurrence of paraplegia and prolong survival time.
July 2016: Medicine (Baltimore)
Lingde Kong, Junming Cao, Yingze Zhang, Wenyuan Ding, Yong Shen
To identify risk factors for periprosthetic joint infection following primary total joint arthroplasty, a systematic search was performed in Pubmed, Embase and Cochrane library databases. Pooled odds ratios (ORs) or standardised mean differences (SMDs) with 95% confidence intervals (CIs) were calculated. Patient characteristics, surgical-related factors and comorbidities, as potential risk factors, were investigated. The main factors associated with infection after total joint arthroplasty (TJA) were male gender (OR, 1·48; 95% CI, 1...
July 10, 2016: International Wound Journal
Helin Feng, Jin Wang, Peng Guo, Jianfa Xu, Wei Chen, Yingze Zhang
BACKGROUND: The spine, pelvis, skull, and femur are the most common sites of bone metastases, and pain is the main symptom of metastatic tumors. Percutaneous femoroplasty (PFP) is becoming increasingly popular for treating proximal femoral metastases. OBJECTIVES: To assess the clinical value and feasibility of PFP performed under the guidance of computed tomography (CT). STUDY DESIGN: A retrospective clinical review comparing pain intensity and the ability to perform activities of daily living before and after treatment with PFP...
July 2016: Pain Physician
Helin Feng, Jin Wang, Wei Chen, Baoen Shan, Yin Guo, Jianfa Xu, Ling Wang, Peng Guo, Yingze Zhang
Osteosarcoma (OS) responds poorly to radiotherapy, but the mechanism is unclear. We found OS tumor tissues expressed high level of protein HIF-1α, a common biological marker indicative of hypoxia. It is known that hypoxic cells are generally radioresistant because of reduced production of irradiation-induced DNA-damaging reactive oxygen species (ROS) in the anaerobic condition. Here we report another mechanism how hypoxia induces radioresistance. In MG-63 human osteosarcoma cells, hypoxic pretreatment increased the cellular survival in irradiation...
June 2016: Journal of Bone Oncology
Jiangning Tan, John R Tedrow, Justin A Dutta, Brenda Juan-Guardela, Mehdi Nouraie, Yanxia Chu, Humberto Trejo Bittar, Kritika Ramani, Partha S Biswas, Kristen L Veraldi, Naftali Kaminski, Yingze Zhang, Daniel J Kass
RATIONALE: Relaxin is a hormone that has been considered as a potential therapy for patients with fibrotic diseases. OBJECTIVES: To gauge the potential efficacy of relaxin-based therapies in idiopathic pulmonary fibrosis (IPF), we studied gene expression for relaxin/insulin-like family peptide receptor 1 (RXFP1) in IPF lungs and controls. METHODS: We analyzed gene expression data obtained from the Lung Tissue Research Consortium and correlated RXFP1 gene expression data with cross-sectional clinical and demographic data...
December 1, 2016: American Journal of Respiratory and Critical Care Medicine
Tasha E Fingerlin, Weiming Zhang, Ivana V Yang, Hannah C Ainsworth, Pamela H Russell, Rachel Z Blumhagen, Marvin I Schwarz, Kevin K Brown, Mark P Steele, James E Loyd, Gregory P Cosgrove, David A Lynch, Steve Groshong, Harold R Collard, Paul J Wolters, Williamson Z Bradford, Karl Kossen, Scott D Seiwert, Roland M du Bois, Christine Kim Garcia, Megan S Devine, Gunnar Gudmundsson, Helgi J Isaksson, Naftali Kaminski, Yingze Zhang, Kevin F Gibson, Lisa H Lancaster, Toby M Maher, Philip L Molyneaux, Athol U Wells, Miriam F Moffatt, Moises Selman, Annie Pardo, Dong Soon Kim, James D Crapo, Barry J Make, Elizabeth A Regan, Dinesha S Walek, Jerry J Daniel, Yoichiro Kamatani, Diana Zelenika, Elissa Murphy, Keith Smith, David McKean, Brent S Pedersen, Janet Talbert, Julia Powers, Cheryl R Markin, Kenneth B Beckman, Mark Lathrop, Brian Freed, Carl D Langefeld, David A Schwartz
BACKGROUND: Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles in familial and sporadic disease. We have previously used genome-wide single nucleotide polymorphism data to identify 10 risk loci for fIIP. Here we extend that work to imputed genome-wide genotypes and conduct new RNA sequencing studies of lung tissue to identify and characterize new fIIP risk loci...
2016: BMC Genetics
Yanbin Zhu, Hengrui Chang, Yiyang Yu, Wei Chen, Song Liu, Yingze Zhang
OBJECTIVES: To evaluate the comparative effectiveness and accuracy of electromagnetic technique (EM) verses free-hand method (FH) for distal locking in intramedullary nailing procedure. MATERIAL AND METHODS: Relevant original studies were searched in Medline, Pubmed, Embase, China National Knowledge Infrastructure, and Cochrane Central Database (all through October 2015). Comparative studies providing sufficient data of interest were included in this meta-analysis...
June 2, 2016: International Orthopaedics
Travis Lear, Alison C McKelvey, Shristi Rajbhandari, Sarah R Dunn, Tiffany A Coon, William Connelly, Joe Y Zhao, Daniel J Kass, Yingze Zhang, Yuan Liu, Bill B Chen
The E3 small ubiquitin-like modifier (SUMO) protein ligase protein inhibitor of activated STAT 4 (PIAS4) is a pivotal protein in regulating the TGFβ pathway. In this study, we discovered a new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFβ signaling pathway through the site-specific ubiquitination of PIAS4. FIEL1 targets PIAS4 using a double locking mechanism that is facilitated by the kinases PKCζ and GSK3β. Specifically, PKCζ phosphorylation of PIAS4 and GSK3β phosphorylation of FIEL1 are both essential for the degradation of PIAS4...
May 30, 2016: Journal of Experimental Medicine
Pan Gao, Yingze Wei, Zhigang Zhang, Wenjiao Zeng, Daming Sun, Danyang Liu, Bo Hou, Congying Zhang, Nong Zhang, Hui Li, Liliang Li
Diabetic nephropathy (DN) is a major complication of diabetes mellitus. Transforming growth factor beta 1 (TGFβ1) is a well-distinguished mediator of progressive renal fibrosis in DN. However, the molecular mechanisms contributing to enhanced TGFβ1 expression in the progression of DN are not fully understood. Herein, we reported that c-Jun and specificity protein 1 (SP1) were critical upstream regulators of TGFβ1 expression in DN. The increase in c-Jun and SP1 expressions was positively correlated with TGFβ1 in both high glucose-treated human renal mesangial cells (HRMCs) and diabetic kidneys...
June 2016: Experimental and Molecular Pathology
Xin Lin, Yuning Chen, Na Liu, Yingze Cao, Liangxin Xu, Weifeng Zhang, Lin Feng
Combined with special wettability and photocatalytic properties, a TiO2 nanocluster-based mesh was constructed, successfully used for emulsion separation and soluble contaminants degradation under UV illumination in one step, with extremely high flux and efficiency. This work provides a new way to develop multifunctional materials for potential use in water remediation.
April 28, 2016: Nanoscale
Junming Cao, Lingde Kong, Fantao Meng, Yingze Zhang, Yong Shen
Controversy exists regarding the effect of obesity on surgical outcomes and complications following lumbar spinal surgery. A systematic electronic literature review of all relevant studies through to June 2015 was performed using the PubMed, Embase, and Cochrane library databases. Pooled risk ratios (RR) or standardised mean differences (SMD) with 95% confidence intervals (CI) were calculated using random or fixed effects models. The Newcastle-Ottawa Scale was used to evaluate the methodological quality, and Stata 11...
June 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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