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https://www.readbyqxmd.com/read/28199135/extreme-trait-whole-genome-sequencing-identifies-ptpro-as-a-novel-candidate-gene-in-emphysema-with-severe-airflow-obstruction
#1
Josiah E Radder, Yingze Zhang, Alyssa D Gregory, Shibing Yu, Neil J Kelly, Joseph K Leader, Naftali Kaminski, Frank C Sciurba, Steven D Shapiro
RATIONALE: Genetic association studies in chronic obstructive pulmonary disease (COPD) have primarily tested for association with common variants, the results of which explain only a portion of disease heritability. As rare variation is also likely to contribute to susceptibility, we employed whole genome sequencing (WGS) of subjects with clinically extreme phenotypes to identify genomic regions enriched for rare variation contributing to COPD susceptibility. OBJECTIVE: Identify regions of rare genetic variation contributing to emphysema with severe airflow obstruction Methods: We identified heavy smokers that were resistant (n=65) or susceptible (n=64) to emphysema with severe airflow obstruction in the Pittsburgh SCCOR cohort...
February 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28179498/loss-of-twist1-in-the-mesenchymal-compartment-promotes-increased-fibrosis-in-experimental-lung-injury-by-enhanced-expression-of-cxcl12
#2
Jiangning Tan, John R Tedrow, Mehdi Nouraie, Justin A Dutta, David T Miller, Xiaoyun Li, Shibing Yu, Yanxia Chu, Brenda Juan-Guardela, Naftali Kaminski, Kritika Ramani, Partha S Biswas, Yingze Zhang, Daniel J Kass
Idiopathic pulmonary fibrosis (IPF) is a disease characterized by the accumulation of apoptosis-resistant fibroblasts in the lung. We have previously shown that high expression of the transcription factor Twist1 may explain this prosurvival phenotype in vitro. However, this observation has never been tested in vivo. We found that loss of Twist1 in COL1A2(+) cells led to increased fibrosis characterized by very significant accumulation of T cells and bone marrow-derived matrix-producing cells. We found that Twist1-null cells expressed high levels of the T cell chemoattractant CXCL12...
February 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28122417/meta-analysis-of-two-surgical-approaches-for-calcaneal-fractures-sinus-tarsi-versus-extensile-lateral-approach
#3
REVIEW
Fei Zhang, Hongtao Tian, Shilun Li, Bo Liu, Tianhua Dong, Yanbin Zhu, Yingze Zhang
BACKGROUND: There remains a controversy between extensile lateral approach and sinus tarsi approach (STA) to treat calcaneal fractures. The aim of this study is to evaluate the medium- and long-term outcomes of the STA versus extensile lateral approach in terms of intraoperative variables, quality of alignment on a lateral radiograph incidence of wound healing complication, visual analogue scale and American Orthopaedic Foot and Ankle Society for the treatment of calcaneal fractures. METHODS: Relevant original studies were searched in PubMed, Medline and Embase and Chinese National Knowledge Infrastructure (January 1990 and November 2015)...
January 25, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28096531/the-first-imported-case-of-rift-valley-fever-in-china-reveals-a-genetic-reassortment-of-different-viral-lineages
#4
Jingyuan Liu, Yulan Sun, Weifeng Shi, Shuguang Tan, Yang Pan, Shujuan Cui, Qingchao Zhang, Xiangfeng Dou, Yanning Lv, Xinyu Li, Xitai Li, Lijuan Chen, Chuansong Quan, Qianli Wang, Yingze Zhao, Qiang Lv, Wenhao Hua, Hui Zeng, Zhihai Chen, Haofeng Xiong, Chengyu Jiang, Xinghuo Pang, Fujie Zhang, Mifang Liang, Guizhen Wu, George F Gao, William J Liu, Ang Li, Quanyi Wang
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved...
January 18, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28093079/albumin-and-surgical-site-infection-risk-in-orthopaedics-a-meta-analysis
#5
Peizhi Yuwen, Wei Chen, Hongzhi Lv, Chen Feng, Yansen Li, Tao Zhang, Pan Hu, Jialiang Guo, Ye Tian, Lei Liu, Jiayuan Sun, Yingze Zhang
BACKGROUD: Surigical site infection has been a challenge for surgeons for many years, the prevalence of serum albumin <3.5g/dL has been reported to be associated with increased orthopaedic complications. However, the prognostic implications and significance of serum albumin <3.5g/dL after orthopaedic surgeries remain ambiguity. In this study, we performed a meta-analysis to access the predictive value of serum albumin level on SSI. METHODS: A basic data search was performed in PubMed and Web of Science, in addition, references were manually searched...
January 16, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28089509/occult-external-iliac-vein-injury-after-anterior-dislocation-of-the-sacroiliac-joint-in-adult-patient
#6
Yueju Liu, Juan Wang, Yingze Zhang
Anterior dislocation of the sacroiliac joint, characterized by dislocation of the ilium anterior to the sacrum, is a subtype of complete posterior pelvic ring disruption. This injury occurs mostly in children. We present an adult patient with anterior dislocation of the sacroiliac joint. It was associated with numerous complications. To the best of our knowledge, it is only the second case reported in the literature.
January 12, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28074258/the-treatment-options-for-posterior-malleolar-fractures-in-tibial-spiral-fractures
#7
Jialiang Guo, Lei Liu, Zongyou Yang, Zhiyong Hou, Wei Chen, Yingze Zhang
PURPOSE: The posterior malleolar fracture (PMF) in tibial spiral fractures are a common type of complication that occurs in tibial fractures. However, the indication of fixation for posterior fractures is still under debate and varies between different surgeons'. It is not unusual to find the smaller PMF (<25%), which could be treated conservatively within guidelines, treated with internal fixation in clinic. The aim of this study is to evaluate the clinical outcomes of tibial spiral fractures with PMF and provide proper guidance for the treatment of this special fracture...
January 10, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/27975055/clinical-effects-of-the-probing-method-with-depth-gauge-for-determining-the-screw-depth-of-locking-proximal-humeral-plate
#8
RANDOMIZED CONTROLLED TRIAL
Lin Jin, Jialiang Guo, Junfei Guo, Yingchao Yin, Zhiyong Hou, Yingze Zhang
Background. The use of locking plates has gained popularity to treat proximal humeral fractures. However, the complication rates remain high. Biomechanical study suggested that subchondral screw-tip abutment significantly increased the stability of plant. We present a simple method to obtain the proper screw length through the depth gauge in elderly patients and compared the clinical effects with traditional measuring method. Methods. 40 patients were separated into two groups according to the two surgical methods: the probing method with depth gauge and the traditional measuring method...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27939207/source-apportionment-and-heavy-metal-health-risk-hmhr-quantification-from-sources-in-a-southern-city-in-china-using-an-me2-hmhr-model
#9
Xing Peng, GuoLiang Shi, GuiRong Liu, Jiao Xu, YingZe Tian, YuFen Zhang, YinChang Feng, Armistead G Russell
Heavy metals (Cr, Co, Ni, As, Cd, and Pb) can be bound to PM adversely affecting human health. Quantifying the source impacts on heavy metals can provide source-specific estimates of the heavy metal health risk (HMHR) to guide effective development of strategies to reduce such risks from exposure to heavy metals in PM2.5 (particulate matter (PM) with aerodynamic diameter less than or equal to 2.5 μm). In this study, a method combining Multilinear Engine 2 (ME2) and a risk assessment model is developed to more effectively quantify source contributions to HMHR, including heavy metal non-cancer risk (non-HMCR) and cancer risk (HMCR)...
February 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27827384/recurrence-rates-and-risk-factors-for-primary-giant-cell-tumors-around-the-knee-a-multicentre-retrospective-study-in-china
#10
Pan Hu, Liming Zhao, Huilin Zhang, Xiuchun Yu, Zhen Wang, Zhaoming Ye, Sujia Wu, Shibing Guo, Guochuan Zhang, Jinghua Wang, Xianjia Ning, Yongcheng Hu, Yingze Zhang
Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27805901/ring-finger-e3-ligase-ppp1r11-regulates-tlr2-signaling-and-innate-immunity
#11
Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino, Joseph S Bednash, Yingze Zhang, Bryan J McVerry, Yuan Liu, Bill B Chen
Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through the ubiquitination and degradation of the receptor in response to ligand stimulation. We show a new mechanism in which an uncharacterized RING finger E3 ligase, PPP1R11, directly ubiquitinates TLR2 both in vitro and in vivo, which leads to TLR2 degradation and disruption of the signaling cascade...
November 2, 2016: ELife
https://www.readbyqxmd.com/read/27782258/in-situ-dual-functional-water-purification-with-simultaneous-oil-removal-and-visible-light-catalysis
#12
Na Liu, Ruixiang Qu, Yuning Chen, Yingze Cao, Weifeng Zhang, Xin Lin, Yen Wei, Lin Feng, Lei Jiang
Dual purification of both oily wastewater and dye-polluted water for enhancing the use of freshwater is an urgent task. We report herein, the facile synthesis of inorganic semiconductor nanomaterials anchored mesh for in situ dual-functional water purification. This resultant mesh combines the excellent capacity of oil removal and the advantage of photocatalytic performance for dye degradation under visible light irradiation at the same time. In addition, the mesh was easily regenerated and remained unaltered in photocatalytic performance over five successive dye degradation cycles...
October 26, 2016: Nanoscale
https://www.readbyqxmd.com/read/27758045/pa-msha-inhibits-the-growth-of-doxorubicin-resistant-mcf-7-adr-human-breast-cancer-cells-by-downregulating-nrf2-p62
#13
Yingze Wei, Danyang Liu, Xiaoxia Jin, Pan Gao, Qingying Wang, Jiawen Zhang, Nong Zhang
Acquired resistance to doxorubicin in breast cancer is a serious therapeutic problem. In this study, we investigated whether Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) could inhibit the growth of doxorubicin-resistant breast cancer cells. We found that the expressions of Nrf2 and p62 in breast cancer were higher than that in the corresponding adjacent normal tissues and benign breast epithelial cell. The expressions of Nrf2 and p62 in breast cancer doxorubicin-resistant cells MCF-7/ADR were higher than that in doxorubicin-sensitive cells MCF-7...
December 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27695039/transcriptional-regulation-of-frizzled-1-in-human-osteoblasts-by-sp1
#14
Shibing Yu, Laura M Yerges-Armstrong, Yanxia Chu, Joseph M Zmuda, Yingze Zhang
The wingless pathway has a powerful influence on bone metabolism and is a therapeutic target in skeletal disorders. Wingless signaling is mediated in part through the Frizzled (FZD) receptor family. FZD transcriptional regulation is poorly understood. Herein we tested the hypothesis that Sp1 plays an important role in the transcriptional regulation of FZD1 expression in osteoblasts and osteoblast mineralization. To test this hypothesis, we conducted FZD1 promoter assays in Saos2 cells with and without Sp1 overexpression...
2016: PloS One
https://www.readbyqxmd.com/read/27597570/fabrication-of-silica-nanospheres-coated-membranes-towards-the-effective-separation-of-oil-in-water-emulsion-in-extremely-acidic-and-concentrated-salty-environments
#15
Yuning Chen, Na Liu, Yingze Cao, Xin Lin, Liangxin Xu, Weifeng Zhang, Yen Wei, Lin Feng
A superhydrophilic and underwater superoleophobic surface is fabricated by simply coating silica nanospheres onto a glass fiber membrane through a sol-gel process. Such membrane has a complex framework with micro and nano structures covering and presents a high efficiency (more than 98%) of oil-in-water emulsion separation under harsh environments including strong acidic and concentrated salty conditions. This membrane also possesses outstanding stability since no obvious decline in efficiency is observed after different kinds of oil-in-water emulsions separation, which provides it candidate for comprehensive applicability...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27588483/activation-of-akt-pathway-by-nrf2-pdgfa-feedback-loop-contributes-to-hcc-progression
#16
Danyang Liu, Yonglong Zhang, Yingze Wei, Guoyuan Liu, Yufeng Liu, Qiongmei Gao, Liping Zou, Wenjiao Zeng, Nong Zhang
Nuclear factor erythroid-2-related factor 2 (Nrf2), a master transcription factor in the antioxidant response, has been found to be ubiquitously expressed in various cancer cells and in the regulation tumor proliferation, invasion, and chemoresistance activities. The regulatory roles of Nrf2 in controlling Hepatocellular carcinoma (HCC) progression remain unclear. In this study, we demonstrated that Nrf2 was significantly elevated in HCC cells and tissues and was correlated with poor prognosis of HCCs. Consistently, Nrf2 significantly promoted HCC cell growth both in vitro and in vivo...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27588074/therapeutic-effect-of-bone-cement-injection-in-the-treatment-of-intraosseous-ganglion-of-the-carpal-bones
#17
Kunlun Yu, Xinzhong Shao, Dehu Tian, Jiangbo Bai, Bing Zhang, Yingze Zhang
The aim of the present study was to treat intraosseous ganglia of the carpal bones with injectable bone cement grafting. Between January 2012 and December 2013, 4 patients (3 men and 1 woman) presenting with wrist pain and activity limitation were diagnosed with intraosseous ganglion of the carpal bones by radiography. The patients were treated with minimal invasive curettage and bone cement injection surgery. All patients were followed up for a mean time of 17 months (range, 12-22 months). The wrist pain was significantly reduced in all patients following surgery...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27494174/polyacrylamide-polydivinylbenzene-decorated-membrane-for-sundry-ionic-stabilized-emulsions-separation-via-a-facile-solvothermal-method
#18
Weifeng Zhang, Na Liu, Yingze Cao, Yuning Chen, Qingdong Zhang, Xin Lin, Ruixiang Qu, Haifang Li, Lin Feng
Aiming to solve the worldwide challenge of stabilized oil-in-water emulsion separation, a PAM-PDVB decorated nylon membrane is fabricated via a facile solvothermal route in our group. The main composition is PAM, while the PDVB plays a role as cross-linker in order to improve the interaction between the polymer and the substrate. By the combination of the superhydrophilic and underwater superoleophobic wettability of the PAM polymer with the micropore size of the substrate, the as-prepared material is able to achieve the separation of various stabilized oil-in-water emulsions including cationic type, nonionic type, and anionic type...
August 24, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27428183/the-surgical-management-and-treatment-of-metastatic-lesions-in-the-proximal-femur-a-mini-review
#19
REVIEW
Helin Feng, Jin Wang, Jianfa Xu, Wei Chen, Yingze Zhang
Review current treatments of metastatic lesions in the proximal femur.We reviewed published literature related to diagnosis and surgical treatments and summarized current treatment options.Surgical management mainly consist of internal fixation, hip replacement, and percutaneous femoroplasty (PFP) which has been newly applied in clinical practice.An appropriate series of treatments is necessary for patients to avoid the occurrence of paraplegia and prolong survival time.
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27397553/risk-factors-for-periprosthetic-joint-infection-following-primary-total-hip-or-knee-arthroplasty-a-meta-analysis
#20
Lingde Kong, Junming Cao, Yingze Zhang, Wenyuan Ding, Yong Shen
To identify risk factors for periprosthetic joint infection following primary total joint arthroplasty, a systematic search was performed in Pubmed, Embase and Cochrane library databases. Pooled odds ratios (ORs) or standardised mean differences (SMDs) with 95% confidence intervals (CIs) were calculated. Patient characteristics, surgical-related factors and comorbidities, as potential risk factors, were investigated. The main factors associated with infection after total joint arthroplasty (TJA) were male gender (OR, 1·48; 95% CI, 1...
July 10, 2016: International Wound Journal
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