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https://www.readbyqxmd.com/read/28941674/do-oil-in-water-o-w-nano-emulsions-have-an-effect-on-survival-and-growth-of-bacteria
#1
Hani El Kadri, Putu Virgina Partha Devanthi, Tim W Overton, Konstantinos Gkatzionis
Nano-emulsions (typically droplet diameter<1μm) are common in foods, and have been extensively reported to present antimicrobial activity, however, the mechanism is not well defined, and some studies reported no effect. A review of the literature was conducted and revealed strongly contradictory reports regarding the antimicrobial effect of nano-emulsions even in reference to similar microbial species and formulations. Following up, this study aimed to investigate the effect of nano-emulsions on four bacterial species (Staphylococcus epidermidis, Bacillus cereus, Lactobacillus acidophilus and five Escherichia coli strains) possessing different surface charge and hydrophobicity...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28923420/high-doses-of-lipid-core-nanocapsules-do-not-affect-bovine-embryonic-development-in-vitro
#2
Caroline Lucas, Mariana Remião, Franciele Bruinsmann, Isadora Lopes, Morgana Borges, Ana Laura Feijó, Andrea Cristina Basso, Adriana Pohlmann, Silvia Guterres, Vinicius Campos, Fabiana Seixas, Tiago Collares
The improvement of in vitro embryo production by culture media supplementation has been a potential tool to increase blastocyst quality and development. Recently, lipid-core nanocapsules (LNC), which were developed for biomedical applications as a drug-delivery system, have demonstrated beneficial effects on in vitro embryo production studies. LNCs have a core composed of sorbitan monostearate dispersed in capric/caprylic triglyceride. Based on that, we firstly investigated if LNCs supplemented during in vitro oocyte maturation had affinity to the mineral oil placed over the top of the IVM media...
September 15, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28922057/the-dietary-food-components-capric-acid-and-caprylic-acid-inhibit-virulence-factors-in-candida-albicans-through-multitargeting
#3
Ashwini Jadhav, Supriya Mortale, Shivkrupa Halbandge, Priyanka Jangid, Rajendra Patil, Wasudev Gade, Kiran Kharat, Sankunny Mohan Karuppayil
Capric acid and caprylic acid are the dietary food components. They are found to inhibit the virulence factors like morphogenesis, adhesion, and biofilm formation in the human pathogenic yeast Candida albicans. Our study demonstrated that yeast-to-hyphal signal transduction pathways were affected by capric acid and caprylic acid. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of Cdc35, Hwp1, Hst7, and Cph1 by the treatment with both the fatty acids. Cell elongation gene, Ece1, was surprisingly downregulated by 5208-fold by the treatment of caprylic acid...
September 18, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28913392/data-on-scaling-up-and-in-vivo-human-study-of-progesterone-lipid-nanoparticles
#4
Elisabetta Esposito, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Claudio Nastruzzi, Rita Cortesi
Progesterone containing nanoparticles constituted of tristearin or tristearin in association with caprylic-capric triglyceride were produced in a lab scale by ultrasound homogenization and in a pilot scale by high pressure homogenization. A study was conducted to select the pressure to be used in order to obtain homogenously sized nanoparticles. The Dialysis method was performed to mimic subcutaneous administration of lipid nanoparticles. Mathematical analyses of the results were conducted to understand and compare the drug release mechanisms...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28830782/mechanism-study-on-ion-pair-complexes-controlling-skin-permeability-effect-of-ion-pair-dissociation-in-the-viable-epidermis-on-transdermal-permeation-of-bisoprolol
#5
Hanqing Zhao, Chao Liu, Peng Quan, Xiaocao Wan, Meiyue Shen, Liang Fang
Though ion-pair strategy has been widely used in transdermal drug delivery system, knowledge about the molecular mechanisms involved in the skin permeation processes of ion-pair complexes is still limited. In the present study, a homologous series of fatty acids were chosen to form model ion-pair complexes with bisoprolol (BSP) to rule out the influence of functional groups on polar surface area, stability and other physicochemical properties of ion-pair complexes. The ion-pair complexes were characterized by FTIR, thermal analysis, and (1)H NMR...
August 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28830752/eastern-brown-snake-pseudonaja-textilis-envenomation-in-dogs-and-cats-clinical-signs-coagulation-changes-brown-snake-venom-antigen-levels-and-treatment-with-a-novel-caprylic-acid-fractionated-bivalent-whole-igg-equine-antivenom
#6
A M Padula, E Leister
This report describes the diagnosis and treatment of 16 confirmed cases of snakebite from the Australian eastern brown snake (Pseudonaja textilis) in dogs and cats. The clinical signs, brown snake venom antigen concentrations, coagulation parameters, and treatment outcomes following administration of an experimental caprylic acid fractionated bivalent whole IgG antivenom are documented. A brown snake venom antigen specific sandwich ELISA was used to retrospectively quantify venom levels in serum and urine. The characteristic clinical signs of envenomation in all cases were neurotoxicity to a variable extent and coagulation disturbances...
August 19, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28817087/the-preparation-and-identification-of-a-monoclonal-antibody-against-domoic-acid-and-establishment-of-detection-by-indirect-competitive-elisa
#7
Abdullah F U H Saeed, Sumei Ling, Jun Yuan, Shihua Wang
Domoic acid (DA) is a potent toxin, marine biotoxin, and primarily produced by Pseudo-nitzschia. The DA hapten was coupled with bovine serum albumin (BSA), and ovalbumin (OVA) as carrier proteins. DA-BSA conjugate was used as immunogen and DA-OVA as coating antigen. Cell fusion between spleen cells and sp2/0 myeloma cells developed 1C3 hybridoma clone producing 1C3 monoclonal antibody (mAb). Hybridoma was injected into the mice to produce ascites, and further purified by caprylic acid/ammonium sulfate method...
August 17, 2017: Toxins
https://www.readbyqxmd.com/read/28805679/controlling-blown-pack-spoilage-using-anti-microbial-packaging
#8
Rachael Reid, Declan Bolton, Andrey A Tiuftin, Joe P Kerry, Séamus Fanning, Paul Whyte
Active (anti-microbial) packaging was prepared using three different formulations; Auranta FV; Inbac-MDA and sodium octanoate at two concentrations (2.5 and 3.5 times their minimum inhibitory concentration (MIC, the lowest concentration that will inhibit the visible growth of the organisms) against Clostridium estertheticum, DSMZ 8809). Inoculated beef samples were packaged using the active packaging and monitored for 100 days storage at 2 °C for blown pack spoilage. The time to the onset of blown pack spoilage was significantly (p < 0...
August 12, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28805665/the-role-of-solvent-accessible-leu-208-of-cold-active-pseudomonas-fluorescens-strain-ams8-lipase-in-interfacial-activation-substrate-accessibility-and-low-molecular-weight-esterification-in-the-presence-of-toluene
#9
Norhayati Yaacob, Nor Hafizah Ahmad Kamarudin, Adam Thean Chor Leow, Abu Bakar Salleh, Raja Noor Zaliha Raja Abd Rahman, Mohd Shukuri Mohamad Ali
The alkaline cold-active lipase from Pseudomonas fluorescens AMS8 undergoes major structural changes when reacted with hydrophobic organic solvents. In toluene, the AMS8 lipase catalytic region is exposed by the moving hydrophobic lid 2 (Glu-148 to Gly-167). Solvent-accessible surface area analysis revealed that Leu-208, which is located next to the nucleophilic Ser-207 has a focal function in influencing substrate accessibility and flexibility of the catalytic pocket. Based on molecular dynamic simulations, it was found that Leu-208 strongly facilitates the lid 2 opening via its side-chain...
August 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28770529/effect-of-surfactants-on-mechanical-thermal-and-photostability-of-a-monoclonal-antibody
#10
Meera Agarkhed, Courtney O'Dell, Ming-Ching Hsieh, Jingming Zhang, Joel Goldstein, Arvind Srivastava
The purpose of this work was to evaluate the effect of commonly used surfactants (at 0.01% w/v concentration) on mechanical, thermal, and photostability of a monoclonal antibody (MAb1) of IgG1 sub-class and to evaluate the minimum concentration of surfactant (Polysorbate 80) required in protecting MAb1 from mechanical stress. Surfactants evaluated were non-ionic surfactants, Polysorbate 80, Polysorbate 20, Pluronic F-68 (polyoxyethylene-polyoxypropylene block polymer), Brij 35 (polyoxyethylene lauryl ether), Triton X-100, and an anionic surfactant, Caprylic acid (1-Heptanecarboxylic acid)...
August 2, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28760448/progesterone-lipid-nanoparticles-scaling-up-and-in-vivo-human-study
#11
Elisabetta Esposito, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Claudio Nastruzzi, Rita Cortesi
This investigation describes a scaling up study aimed at producing progesterone containing nanoparticles in a pilot scale. Particularly hot homogenization techniques based on ultrasound homogenization or high pressure homogenization have been employed to produce lipid nanoparticles constituted of tristearin or tristearin in association with caprylic-capric triglyceride. It was found that the high pressure homogenization method enabled to obtain nanoparticles without agglomerates and smaller mean diameters with respect to ultrasound homogenization method...
October 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28711641/tacrolimus-loaded-biocompatible-lecithin-based-microemulsions-with-improved-skin-penetration-structure-characterization-and-in-vitro-in-vivo-performances
#12
Vedrana Savić, Marija Todosijević, Tanja Ilić, Milica Lukić, Evgenia Mitsou, Vassiliki Papadimitriou, Spyridon Avramiotis, Bojan Marković, Nebojša Cekić, Snežana Savić
In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene glycol monocaprylate as oil phase. The influence of excipients on the size of microemulsion region in pseudo-ternary phase diagrams and their ability to form different types of microemulsions was evaluated. The comprehensive physicochemical characterization of microemulsions and the evaluation of their structure was performed, while the localization of tacrolimus in microemulsions was further investigated using electron paramagnetic resonance spectroscopy...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28691884/synergistic-antimicrobial-combinations-inhibit-and-inactivate-listeria-monocytogenes-in-neutral-and-acidic-broth-systems
#13
Sarah M Kozak, Kyle M Margison, Dennis J D'amico
The use of antimicrobial compounds can be an effective approach to control Listeria monocytogenes in ready-to-eat foods, but it can also be limited by cost, restrictions on concentrations in foods, and potential changes to organoleptic properties. Combinatorial approaches that produce additive or synergistic effects allow for reductions in individual antimicrobial concentrations while achieving the same level of control. The present study determined the MIC and MBC of an antimicrobial compound when used alone or in binary combinations against L...
August 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28656942/formulation-characterisation-and-in-vitro-skin-diffusion-of-nanostructured-lipid-carriers-for-deoxyarbutin-compared-to-a-nanoemulsion-and-conventional-cream
#14
Rendra P Tofani, Yeyet C Sumirtapura, Sasanti T Darijanto
The long-term use of topical hydroquinone as an anti-hyperpigmentation treatment has well-known, unwanted effects. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol) is a relatively new tyrosinase inhibitor, with stronger inhibitory potency than hydroquinone, that exhibited decreased cytotoxicity against melanocytes and other cells. This study developed novel nanostructured lipid carriers (NLCs) for improved topical delivery of deoxyarbutin (dArb), leading to improved depigmenting efficacy. dArb is a hydrophobic substance, but it easily degrades in aqueous medium and is thermolabile...
July 20, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28651962/fatty-acid-composition-of-free-living-and-parasitic-stages-of-the-bovine-lungworm-dictyocaulus-viviparus
#15
Ann-Christin Becker, Ina Willenberg, Andrea Springer, Nils Helge Schebb, Pablo Steinberg, Christina Strube
The development of parasitic nematodes proceeds via multiple stages, often implicating the necessity to adapt to different environments. Especially the transition from free-living to parasitic stages is accompanied by a significant change in the environmental conditions. To shed light on possible adaptations to these transitions, the fatty acid composition of different developmental stages of the bovine lungworm Dictyocaulus viviparus was investigated. Fatty acids of D. viviparus eggs, the free-living first, second and third larval stage (L1-L3) as well as the parasitic preadult stage and adult male and female worms residing in the lungs of infected hosts were quantified by gas chromatography after transesterification to their fatty acid methyl esters...
June 23, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28620602/caprylate-salts-based-on-amines-as-volatile-corrosion-inhibitors-for-metallic-zinc-theoretical-and-experimental-studies
#16
Marco A G Valente, Deiver A Teixeira, David L Azevedo, Gustavo T Feliciano, Assis V Benedetti, Cecílio S Fugivara
The interaction of volatile corrosion inhibitors (VCI), caprylate salt derivatives from amines, with zinc metallic surfaces is assessed by density functional theory (DFT) computer simulations, electrochemical impedance (EIS) measurements and humid chamber tests. The results obtained by the different methods were compared, and linear correlations were obtained between theoretical and experimental data. The correlations between experimental and theoretical results showed that the molecular size is the determining factor in the inhibition efficiency...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28618384/a-fatty-acid-solvent-of-switchable-miscibility
#17
Qianqian Chen, Lei Wang, Gaihuan Ren, Qian Liu, Zhenghe Xu, Dejun Sun
Ion pair interactions were explored to design a fatty acid solvent of switchable miscibility with water. Fatty acids of medium length chains are immiscible with water but become miscible with water when ion pairs are formed with amines. The ion pairs become phase separated after bubbling CO2 into the solution due to the dissociation of the fatty acid-amine complexes. Ion pairs of caprylic acid (C8) and low toxic poly(oxypropylene) diamine (Jeffamine D-230) were characterized by FT-IR and (1)H NMR. Log Kow values and surface activity were used to understand the switchable solvent mechanism in removing and recovering oily contaminants...
June 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28558229/catalytic-dyad-in-the-sgnh-hydrolase-superfamily-in-depth-insight-into-structural-parameters-tuning-the-catalytic-process-of-extracellular-lipase-from-streptomyces-rimosus
#18
Ivana Leščić Ašler, Zoran Štefanić, Aleksandra Maršavelski, Robert Vianello, Biserka Kojić-Prodić
SrLip is an extracellular enzyme from Streptomyces rimosus (Q93MW7) exhibiting lipase, phospholipase, esterase, thioesterase, and tweenase activities. The structure of SrLip is one of a very few lipases, among the 3D-structures of the SGNH superfamily of hydrolases, structurally characterized by synchrotron diffraction data at 1.75 Å resolution (PDB: 5MAL ). Its crystal structure was determined by molecular replacement using a homology model based on the crystal structure of phospholipase A1 from Streptomyces albidoflavus (PDB: 4HYQ )...
June 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28543784/improvement-of-hydration-and-epidermal-barrier-function-in-human-skin-by-a-novel-compound-isosorbide-dicaprylate
#19
R K Chaudhuri, K Bojanowski
OBJECTIVE: The study involved the synthesis of a novel derivative of caprylic acid - isosorbide dicaprylate (IDC) - and the evaluation of its potential in improving water homoeostasis and epidermal barrier function in human skin. METHODS: The effect of IDC on gene expression was assayed in skin organotypic cultures by DNA microarrays. The results were then confirmed for a few key genes by quantitative PCR, immuno- and cytochemistry. Final validation of skin hydration properties was obtained by four separate clinical studies...
October 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28508264/biological-safety-of-a-highly-purified-10-liquid-intravenous-immunoglobulin-preparation-from-human-plasma
#20
Caroline Goussen, Steve Simoneau, Soline Bérend, Christine Jehan-Kimmel, Anne Bellon, Céline Ducloux, Bruno You, Philippe Paolantonacci, Monique Ollivier, Ludovic Burlot, Sami Chtourou, Benoît Flan
BACKGROUND: A highly purified 10% liquid intravenous immunoglobulin, IQYMUNE(®), has been developed using an innovative manufacturing process including an affinity chromatography step for the removal of anti-A and anti-B hemagglutinins. OBJECTIVES: The pathogen (viruses and prions) clearance efficacy of the manufacturing process and its robustness for critical steps were investigated. METHODS: The manufacturing process of IQYMUNE(®) includes two dedicated complementary virus reduction steps: solvent/detergent (S/D) treatment and 20 nm nanofiltration as well as two contributing steps, namely caprylic acid fractionation and anion-exchange chromatography...
June 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
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