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https://www.readbyqxmd.com/read/29287355/exploring-a-volatomic-based-strategy-for-a-fingerprinting-approach-of-vaccinium-padifolium-l-berries-at-different-ripening-stages
#1
Priscilla Porto-Figueira, José A Figueira, Pedro Berenguer, José S Câmara
The effect of ripening on the evolution of the volatomic pattern from endemic Vaccinium padifolium L. (Uveira) berries was investigated using headspace-solid phase microextraction (HS-SPME) followed by gas chromatography/quadrupole-mass spectrometry (GC-qMS) and multivariate statistical analysis (MVA). The most significant HS-SPME parameters, namely fibre polymer, ionic strength and extraction time, were optimized in order to improve extraction efficiency. Under optimal experimental conditions (DVB/CAR/PDMS fibre coating, 40°C, 30min extraction time and 5g of sample amount), a total of 72 volatiles of different functionalities were isolated and identified...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29274970/control-of-listeria-monocytogenes-in-whole-milk-using-antimicrobials-applied-individually-and-in-combination
#2
Sarah M Kozak, Stephanie R B Brown, Yustyna Bobak, Dennis J D'Amico
Dairy product recalls and dairy-related illnesses are often the result of contamination with Listeria monocytogenes, which can occur throughout the dairy production and supply chains. The use of antimicrobial compounds is one practical approach for controlling pathogen survival and growth in foods. The goal of this study was to use fluid milk as a model system to identify listeristatic or listericidal treatments that show promise for application in fluid milk and for further evaluation in other dairy products (e...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29250753/the-purification-and-characterization-of-lipases-from-lasiodiplodia-theobromae-and-their-immobilization-and-use-for-biodiesel-production-from-coconut-oil
#3
Balaji Venkatesagowda, Ebenezer Ponugupaty, Aneli M Barbosa-Dekker, Robert F H Dekker
The coconut kernel-associated fungus, Lasiodiplodia theobromae VBE1, was grown on coconut cake with added coconut oil as lipase inducer under solid-state fermentation conditions. The extracellular-produced lipases were purified and resulted in two enzymes: lipase A (68,000 Da)-purified 25.41-fold, recovery of 47.1%-and lipase B (32,000 Da)-purified 18.47-fold, recovery of 8.2%. Both lipases showed optimal activity at pH 8.0 and 35 °C, were activated by Ca2+, exhibited highest specificity towards coconut oil and p-nitrophenyl palmitate, and were stable in iso-octane and hexane...
December 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29247821/lipase-inorganic-hybrid-nanoflower-constructed-through-biomimetic-mineralization-a-new-support-for-biodiesel-synthesis
#4
Wei Jiang, Xinghuo Wang, Jiebing Yang, Haobo Han, Quanshun Li, Jun Tang
We reported a facile, economic and green method based on biomimetic mineralization to acquire lipase-inorganic hybrid nanoflower, which was then employed as a biocatalyst for biodiesel production. In the hybrid nanoflower, enzyme molecules and Cu2+ ions were utilized as the organic and inorganic components, respectively. The morphology of nanoflower and the distribution and loading of proteins were systematically characterized by scanning electron microscopy, confocal laser scanning microscopy and ultraviolet-visible spectroscopy, which indicated the successful encapsulation of lipase in the hybrid nanoflower...
December 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29247333/medium-chain-fatty-acids-mcfa-production-through-anaerobic-fermentation-using-clostridium-kluyveri-effect-of-ethanol-and-acetate
#5
M Venkateswar Reddy, S Venkata Mohan, Young-Cheol Chang
Medium-chain fatty acids (MCFA) are saturated monocarboxylic acids and can be used as antimicrobials, corrosion inhibitors, precursors in biodiesel, and bioplastic production. In the present study, MCFA production was evaluated with acetate and ethanol using the bacteria Clostridium kluyveri. Effects of substrate, electron donor, and methane inhibitor on MCFA production were evaluated. Bacteria successfully converted the ethanol and acetate to butyrate (C4), caproate (C6), and caprylate (C8) by chain elongation process...
December 16, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29228833/in-vitro-in-silico-approach-in-the-development-of-simvastatin-loaded-self-microemulsifying-drug-delivery-systems
#6
Zora Ćetković, Sandra Cvijić, Dragana Vasiljević
OBJECTIVE: The aims of this study were to formulate simvastatin (SV)-loaded self-microemulsifying drug delivery systems (SMEDDS), and explore the potential of these drug delivery systems to improve SV solubility, and also to identify the optimal place in the gastrointestinal (GI) tract for the release of SV using coupled in vitro/in silico approach. SIGNIFICANCE: In comparison to other published results, this study considered the extensive presystemic clearance of SV, which could significantly decrease its systemic and hepatic bioavailability if SV is delivered into the small intestine...
December 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29209877/effects-of-fish-and-grape-seed-oils-as-core-of-haloperidol-loaded-nanocapsules-on-oral-dyskinesia-in-rats
#7
Dalila Moter Benvegnú, Katiane Roversi, Raquel Cristine Silva Barcelos, Fabíola Trevizol, Camila Simonetti Pase, Hecson Jesser Segat, Verônica Tironi Dias, Ana Luiza Savian, Bruna Lopes Piccoli, Jaqueline Piccolo, Carlos Severo Dutra-Filho, Tatiana Emanuelli, Cristiane de Bona da Silva, Ruy Carlos Ruver Beck, Marilise Escobar Burger
Haloperidol is a widely used antipsychotic, despite the severe motor side effects associated with its chronic use. This study was carried out to compare oral dyskinesia induced by different formulations of haloperidol-loaded nanocapsules containing caprylic/capric triglycerides, fish oil or grape seed oil (GSO) as core, as well as free haloperidol. Haloperidol-loaded lipid-core nanocapsules formulations were prepared, physicochemical characterized and administered (0.5 mg kg-1-ip) to rats for 28 days. Oral dyskinesia was evaluated acutely and subchronically and after that cell viability and free radical generation in cortex and substantia nigra...
December 5, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29199206/preparation-of-salicylic-acid-loaded-nanostructured-lipid-carriers-using-box-behnken-design-optimization-characterization-and-physicochemical-stability
#8
Ketrawee Pantub, Paveena Wongtrakul, Wicharn Janwitayanuchit
Nanostructured lipid carriers loaded salicylic acid (NLCs-SA) were developed and optimized by using the design of experiment (DOE). Box-Behnken experimental design of 3-factor, 3-level was applied for optimization of nanostructured lipid carriers prepared by emulsification method. The independent variables were total lipid concentration (X1), stearic acid to Lexol® GT-865 ratio (X2) and Tween® 80 concentration (X3) while the particle size was a dependent variable (Y). Box-Behnken design could create 15 runs by setting response optimizer as minimum particle size...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29160871/molecular-mechanism-of-activation-of-burkholderia-cepacia-lipase-at-aqueous-organic-interfaces
#9
Ivan Pires de Oliveira, Gabriel Ernesto Jara, Leandro Martínez
Lipases are water-soluble enzymes that catalyze the hydrolysis of lipids. Since lipids are mostly hydrophobic, lipase activity occurs preferentially at interfaces of aqueous and organic phases. In this work, we study the molecular mechanisms by which the Burkholderia cepacia lipase (BCL) is activated at interfaces of water with octane and with methyl caprylate (CAME). We show that BCL assumes very rapidly a preferential orientation at the interfaces, in which the active site is exposed to the organic phase...
November 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29146968/heterologous-expression-and-characterization-of-a-new-lipase-from-pseudomonas-fluorescens-pf0-1-and-used-for-biodiesel-production
#10
Wu Liu, Menggang Li, Yunjun Yan
As a kind of important biocatalysts, Pseudomonas lipases are commonly applied in various industrial fields. Pflip1, a new extracellular lipase gene from Pseudomonas. fluorescens Pf0-1, was first cloned and respectively expressed in Escherichia coli BL21(DE3) and Pichia pastoris KM71, the recombinant proteins Pflip1a and Pflip1b were later purified separately. Then Pflip1a was further characterized. The optimum pH of Pflip1a was 8.0 and its optimal temperature was 70 °C. After incubation at 70 °C for 12 h, Pflip1a could retain over 95% of its original activity...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093703/caprylic-and-polygalacturonic-acid-combinations-for-eradication-of-microbial-organisms-embedded-in-biofilm
#11
Joel Rosenblatt, Ruth A Reitzel, Nylev Vargas-Cruz, Anne-Marie Chaftari, Ray Hachem, Issam Raad
There is a need for non-antibiotic, antimicrobial compositions with low toxicity capable of broad-spectrum eradication of pathogenic biofilms in food preparation and healthcare settings. In this study we demonstrated complete biofilm eradication within 60 min with synergistic combinations of caprylic and polygalacturonic (PG) acids in an in vitro biofilm eradication model against representative hospital and foodborne infectious pathogen biofilms (methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, Candida albicans, Escherichia coli, and Salmonella enteritidis)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29089848/changes-in-the-chemical-composition-of-plum-distillate-during-maturation-with-oak-chips-under-different-conditions
#12
Maria Balcerek, Katarzyna Pielech-Przybylska, Urszula Dziekońska-Kubczak, Piotr Patelski, Ewelina Strąk
This study investigates the effect of ageing on the qualitative and quantitative composition of plum distillate in contact with oak wood chips. Maturation was performed with lightly toasted French oak (Quercus sessiflora and Quercus robur) chips or oak chips made from fragments of empty barrels that had been used for ageing cognac. The effects of oak chip dose, process temperature, ageing system (static or circulatory) and ultrasound treatment were assessed. Maturation of plum distillate samples with oak chips resulted in higher levels of extractable organics (including tannins) and colour changes, which were correlated with the type and dose of oak chips, and the conditions of maturation...
September 2017: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/29043450/immobilization-of-lipase-on-carboxylic-acid-modified-silica-nanoparticles-for-olive-oil-glycerolysis
#13
Abhishek Kumar Singh, Mausumi Mukhopadhyay
In this study, the silica nanoparticles surface was modified by carboxylic acid with different number of alkyl chain and two different lipases were immobilized on it to increase the glycerolysis activity of the immobilized lipases in organic solvent system. Silica nanoparticles of about 15 nm diameter were grafted with various carboxylic acid modifiers from valeric, caprylic, capric, lauric, stearic and oleic acids. Lipases from Candida antarctica and Candida rugosa were immobilized onto the carboxylic acid, modified silica nanoparticles and used in the mono and diglycerides production through glycerolysis with or without organic solvents...
October 17, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29031387/metabolic-pathways-of-oleic-and-palmitic-acid-are-intensified-in-pcos-patients-with-normal-androgen-levels
#14
Szczuko Małgorzata, Zapałowska-Chwyć Marta, Drozd Arleta, Maciejewska Dominika, Starczewski Andrzej, Stachowska Ewa
CONTEXT: The aetiology and pathogenesis polycystic ovary syndrome (PCOS) remain uncertain and thus the relative studies are still crucial. OBJECTIVE: Our aim was to analyse the fatty acids profiles of the main phospholipids species in serum from women with PCOS classified into phenotypes, and to diagnose women more susceptible to the occurrence of inflammatory state. DESIGN: PCOS screening tests were performed in The Clinic of Gynecology and Urogynecology of Pomeranian Medical University in the 2014-2015 years...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28972495/characterization-of-sulphide-silt-pe-loids-in-some-lakes-within-adjara-region-and-determination-of-the-biologically-active-compounds-content
#15
T Masiukovichi, M Jokhadze, T Murtazashvili, A Bakuridze
Medicinal muds, so called Peloids in the last decade attract attention in many countries as effective means for the treatment- preventive, and perfumery-cosmetic purposes. It has been established that the possibilities of this formation of nature are not limited to the many-year experience of the mankind. In terms of further improvement of the human social sphere, nowadays peloids are referred to as XXI century material. The aim of the research was to study the physical-chemical characteristics, such as: humidity, pH, ash content, bulk (volumetric) density and organoleptic properties of sulphide silt peloids of some Adjara region lakes, as well as to determine the content of mineral and organic compounds (humic and organic acids)...
September 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28959352/production-of-erythropoietin-specific-polyclonal-antibodies
#16
Kourosh Maboudi, Seyedeh Marzieh Hosseini, Mina Sepahi, Hashem Yaghoubi, Shahin Hadadian
BACKGROUND: Erythropoietin, as a principal hormone promotes red blood cell production in bone marrow. Varieties of erythropoietin biosimilar are being produced by recombinant DNA technology in cell cultures. The detection or quantifi cation of these molecules are being performed by diff erent methods which some of theme such as Western blot and enzymelinked immunosorbent assay (ELISA) require specifi c antibodies. High cost, inappropriate shipping (cold chain failures), reduced sensitivity and thus poor detection performance are common pitfalls of using commercial kits for performing immunological tests...
March 2017: Iranian Journal of Biotechnology
https://www.readbyqxmd.com/read/28954958/role-of-fatty-acid-salts-as-anti-acanthamoeba-agents-for-disinfecting-contact-lens
#17
Aya Tanaka, Mariko Era, Yumeho Obata, Manami Masuda, Takayoshi Kawahara, Takahide Kanyama, Hiroshi Morita
 Acanthamoeba is found in seawater, fresh water, and soil and is an opportunistic pathogen that causes a potentially blinding corneal infection known as Acanthamoeba keratitis. The anti-amoeba activity of 9 fatty acid salts (potassium butyrate (C4K), caproate (C6K), caprylate (C8K), caprate (C10K), laurate (C12K), myristate (C14K), oleate (C18:1K), linoleate (C18:2K), and linolenate (C18:3K)) was tested on Acanthamoeba castellanii ATCC 30010 (trophozoites and cysts). Fatty acid salts (350 mM and pH 10.5) were prepared by mixing fatty acids with the appropriate amount of KOH...
2017: Biocontrol Science
https://www.readbyqxmd.com/read/28941674/do-oil-in-water-o-w-nano-emulsions-have-an-effect-on-survival-and-growth-of-bacteria
#18
Hani El Kadri, Putu Virgina Partha Devanthi, Tim W Overton, Konstantinos Gkatzionis
Nano-emulsions (typically droplet diameter<1μm) are common in foods, and have been extensively reported to present antimicrobial activity, however, the mechanism is not well defined, and some studies reported no effect. A review of the literature was conducted and revealed strongly contradictory reports regarding the antimicrobial effect of nano-emulsions even in reference to similar microbial species and formulations. Following up, this study aimed to investigate the effect of nano-emulsions on four bacterial species (Staphylococcus epidermidis, Bacillus cereus, Lactobacillus acidophilus and five Escherichia coli strains) possessing different surface charge and hydrophobicity...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28923420/high-doses-of-lipid-core-nanocapsules-do-not-affect-bovine-embryonic-development-in-vitro
#19
Caroline G Lucas, Mariana H Remião, Franciele A Bruinsmann, Isadora A R Lopes, Morgana A Borges, Ana Laura S Feijó, Andrea Cristina Basso, Adriana R Pohlmann, Silvia S Guterres, Vinicius F Campos, Fabiana K Seixas, Tiago Collares
The improvement of in vitro embryo production by culture media supplementation has been a potential tool to increase blastocyst quality and development. Recently, lipid-core nanocapsules (LNC), which were developed for biomedical applications as a drug-delivery system, have demonstrated beneficial effects on in vitro embryo production studies. LNCs have a core composed of sorbitan monostearate dispersed in capric/caprylic triglyceride. Based on that, we firstly investigated if LNCs supplemented during in vitro oocyte maturation had affinity to the mineral oil placed over the top of the IVM media...
December 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28922057/the-dietary-food-components-capric-acid-and-caprylic-acid-inhibit-virulence-factors-in-candida-albicans-through-multitargeting
#20
Ashwini Jadhav, Supriya Mortale, Shivkrupa Halbandge, Priyanka Jangid, Rajendra Patil, Wasudev Gade, Kiran Kharat, Sankunny Mohan Karuppayil
Capric acid and caprylic acid are the dietary food components. They are found to inhibit the virulence factors like morphogenesis, adhesion, and biofilm formation in the human pathogenic yeast Candida albicans. Our study demonstrated that yeast-to-hyphal signal transduction pathways were affected by capric acid and caprylic acid. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of Cdc35, Hwp1, Hst7, and Cph1 by the treatment with both the fatty acids. Cell elongation gene, Ece1, was surprisingly downregulated by 5208-fold by the treatment of caprylic acid...
November 2017: Journal of Medicinal Food
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