keyword
MENU ▼
Read by QxMD icon Read
search

Caprylic

keyword
https://www.readbyqxmd.com/read/28805679/controlling-blown-pack-spoilage-using-anti-microbial-packaging
#1
Rachael Reid, Declan Bolton, Andrey A Tiuftin, Joe P Kerry, Séamus Fanning, Paul Whyte
Active (anti-microbial) packaging was prepared using three different formulations; Auranta FV; Inbac-MDA and sodium octanoate at two concentrations (2.5 and 3.5 times their minimum inhibitory concentration (MIC, the lowest concentration that will inhibit the visible growth of the organisms) against Clostridium estertheticum, DSMZ 8809). Inoculated beef samples were packaged using the active packaging and monitored for 100 days storage at 2 °C for blown pack spoilage. The time to the onset of blown pack spoilage was significantly (p < 0...
August 12, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28805665/the-role-of-solvent-accessible-leu-208-of-cold-active-pseudomonas-fluorescens-strain-ams8-lipase-in-interfacial-activation-substrate-accessibility-and-low-molecular-weight-esterification-in-the-presence-of-toluene
#2
Norhayati Yaacob, Nor Hafizah Ahmad Kamarudin, Adam Thean Chor Leow, Abu Bakar Salleh, Raja Noor Zaliha Raja Abd Rahman, Mohd Shukuri Mohamad Ali
The alkaline cold-active lipase from Pseudomonas fluorescens AMS8 undergoes major structural changes when reacted with hydrophobic organic solvents. In toluene, the AMS8 lipase catalytic region is exposed by the moving hydrophobic lid 2 (Glu-148 to Gly-167). Solvent-accessible surface area analysis revealed that Leu-208, which is located next to the nucleophilic Ser-207 has a focal function in influencing substrate accessibility and flexibility of the catalytic pocket. Based on molecular dynamic simulations, it was found that Leu-208 strongly facilitates the lid 2 opening via its side-chain...
August 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28770529/effect-of-surfactants-on-mechanical-thermal-and-photostability-of-a-monoclonal-antibody
#3
Meera Agarkhed, Courtney O'Dell, Ming-Ching Hsieh, Jingming Zhang, Joel Goldstein, Arvind Srivastava
The purpose of this work was to evaluate the effect of commonly used surfactants (at 0.01% w/v concentration) on mechanical, thermal, and photostability of a monoclonal antibody (MAb1) of IgG1 sub-class and to evaluate the minimum concentration of surfactant (Polysorbate 80) required in protecting MAb1 from mechanical stress. Surfactants evaluated were non-ionic surfactants, Polysorbate 80, Polysorbate 20, Pluronic F-68 (polyoxyethylene-polyoxypropylene block polymer), Brij 35 (polyoxyethylene lauryl ether), Triton X-100, and an anionic surfactant, Caprylic acid (1-Heptanecarboxylic acid)...
August 2, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28760448/progesterone-lipid-nanoparticles-scaling-up-and-in-vivo-human-study
#4
Elisabetta Esposito, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Claudio Nastruzzi, Rita Cortesi
This investigation describes a scaling up study aimed at producing progesterone containing nanoparticles in a pilot scale. Particularly hot homogenization techniques based on ultrasound homogenization or high pressure homogenization have been employed to produce lipid nanoparticles constituted of tristearin or tristearin in association with caprylic-capric triglyceride. It was found that the high pressure homogenization method enabled to obtain nanoparticles without agglomerates and smaller mean diameters with respect to ultrasound homogenization method...
July 28, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28711641/tacrolimus-loaded-biocompatible-lecithin-based-microemulsions-with-improved-skin-penetration-structure-characterization-and-in-vitro-in-vivo-performances
#5
Vedrana Savić, Marija Todosijević, Tanja Ilić, Milica Lukić, Evgenia Mitsou, Vassiliki Papadimitriou, Spyridon Avramiotis, Bojan Marković, Nebojša Cekić, Snežana Savić
In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene glycol monocaprylate as oil phase. The influence of excipients on the size of microemulsion region in pseudo-ternary phase diagrams and their ability to form different types of microemulsions was evaluated. The comprehensive physicochemical characterization of microemulsions and the evaluation of their structure was performed, while the localization of tacrolimus in microemulsions was further investigated using electron paramagnetic resonance spectroscopy...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28691884/synergistic-antimicrobial-combinations-inhibit-and-inactivate-listeria-monocytogenes-in-neutral-and-acidic-broth-systems
#6
Sarah M Kozak, Kyle M Margison, Dennis J D'amico
The use of antimicrobial compounds can be an effective approach to control Listeria monocytogenes in ready-to-eat foods, but it can also be limited by cost, restrictions on concentrations in foods, and potential changes to organoleptic properties. Combinatorial approaches that produce additive or synergistic effects allow for reductions in individual antimicrobial concentrations while achieving the same level of control. The present study determined the MIC and MBC of an antimicrobial compound when used alone or in binary combinations against L...
July 10, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28656942/formulation-characterisation-and-in-vitro-skin-diffusion-of-nanostructured-lipid-carriers-for-deoxyarbutin-compared-to-a-nanoemulsion-and-conventional-cream
#7
Rendra P Tofani, Yeyet C Sumirtapura, Sasanti T Darijanto
The long-term use of topical hydroquinone as an anti-hyperpigmentation treatment has well-known, unwanted effects. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol) is a relatively new tyrosinase inhibitor, with stronger inhibitory potency than hydroquinone, that exhibited decreased cytotoxicity against melanocytes and other cells. This study developed novel nanostructured lipid carriers (NLCs) for improved topical delivery of deoxyarbutin (dArb), leading to improved depigmenting efficacy. dArb is a hydrophobic substance, but it easily degrades in aqueous medium and is thermolabile...
July 20, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28651962/fatty-acid-composition-of-free-living-and-parasitic-stages-of-the-bovine-lungworm-dictyocaulus-viviparus
#8
Ann-Christin Becker, Ina Willenberg, Andrea Springer, Nils Helge Schebb, Pablo Steinberg, Christina Strube
The development of parasitic nematodes proceeds via multiple stages, often implicating the necessity to adapt to different environments. Especially the transition from free-living to parasitic stages is accompanied by a significant change in the environmental conditions. To shed light on possible adaptations to these transitions, the fatty acid composition of different developmental stages of the bovine lungworm Dictyocaulus viviparus was investigated. Fatty acids of D. viviparus eggs, the free-living first, second and third larval stage (L1-L3) as well as the parasitic preadult stage and adult male and female worms residing in the lungs of infected hosts were quantified by gas chromatography after transesterification to their fatty acid methyl esters...
June 23, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28620602/caprylate-salts-based-on-amines-as-volatile-corrosion-inhibitors-for-metallic-zinc-theoretical-and-experimental-studies
#9
Marco A G Valente, Deiver A Teixeira, David L Azevedo, Gustavo T Feliciano, Assis V Benedetti, Cecílio S Fugivara
The interaction of volatile corrosion inhibitors (VCI), caprylate salt derivatives from amines, with zinc metallic surfaces is assessed by density functional theory (DFT) computer simulations, electrochemical impedance (EIS) measurements and humid chamber tests. The results obtained by the different methods were compared, and linear correlations were obtained between theoretical and experimental data. The correlations between experimental and theoretical results showed that the molecular size is the determining factor in the inhibition efficiency...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28618384/a-fatty-acid-solvent-of-switchable-miscibility
#10
Qianqian Chen, Lei Wang, Gaihuan Ren, Qian Liu, Zhenghe Xu, Dejun Sun
Ion pair interactions were explored to design a fatty acid solvent of switchable miscibility with water. Fatty acids of medium length chains are immiscible with water but become miscible with water when ion pairs are formed with amines. The ion pairs become phase separated after bubbling CO2 into the solution due to the dissociation of the fatty acid-amine complexes. Ion pairs of caprylic acid (C8) and low toxic poly(oxypropylene) diamine (Jeffamine D-230) were characterized by FT-IR and (1)H NMR. Log Kow values and surface activity were used to understand the switchable solvent mechanism in removing and recovering oily contaminants...
June 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28558229/catalytic-dyad-in-the-sgnh-hydrolase-superfamily-in-depth-insight-into-structural-parameters-tuning-the-catalytic-process-of-extracellular-lipase-from-streptomyces-rimosus
#11
Ivana Leščić Ašler, Zoran Štefanić, Aleksandra Maršavelski, Robert Vianello, Biserka Kojić-Prodić
SrLip is an extracellular enzyme from Streptomyces rimosus (Q93MW7) exhibiting lipase, phospholipase, esterase, thioesterase, and tweenase activities. The structure of SrLip is one of a very few lipases, among the 3D-structures of the SGNH superfamily of hydrolases, structurally characterized by synchrotron diffraction data at 1.75 Å resolution (PDB: 5MAL ). Its crystal structure was determined by molecular replacement using a homology model based on the crystal structure of phospholipase A1 from Streptomyces albidoflavus (PDB: 4HYQ )...
June 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28543784/improvement-of-hydration-and-epidermal-barrier-function-in-human-skin-by-a-novel-compound-isosorbide-dicaprylate
#12
Ratan K Chaudhuri, Krzysztof Bojanowski
OBJECTIVE: The study involved the synthesis of a novel derivative of caprylic acid - isosorbide dicaprylate (IDC) - and the evaluation of its potential in improving water homeostasis and epidermal barrier function in human skin. METHODS: The effect of IDC on gene expression was assayed in skin organotypic cultures by DNA microarrays. The results were then confirmed for a few key genes by quantitative PCR, immuno- and cytochemistry. Final validation of skin hydration properties was obtained by four separate clinical studies...
May 24, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28508264/biological-safety-of-a-highly-purified-10-liquid-intravenous-immunoglobulin-preparation-from-human-plasma
#13
Caroline Goussen, Steve Simoneau, Soline Bérend, Christine Jehan-Kimmel, Anne Bellon, Céline Ducloux, Bruno You, Philippe Paolantonacci, Monique Ollivier, Ludovic Burlot, Sami Chtourou, Benoît Flan
BACKGROUND: A highly purified 10% liquid intravenous immunoglobulin, IQYMUNE(®), has been developed using an innovative manufacturing process including an affinity chromatography step for the removal of anti-A and anti-B hemagglutinins. OBJECTIVES: The pathogen (viruses and prions) clearance efficacy of the manufacturing process and its robustness for critical steps were investigated. METHODS: The manufacturing process of IQYMUNE(®) includes two dedicated complementary virus reduction steps: solvent/detergent (S/D) treatment and 20 nm nanofiltration as well as two contributing steps, namely caprylic acid fractionation and anion-exchange chromatography...
June 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28466275/development-of-fluorescence-linked-immunosorbent-assay-for-icariin
#14
Jinjun Cheng, Yan Zhao, Meiling Zhang, Yue Zhang, Xiaoman Liu, Xin Yan, Yongzhi Wang, Ziwei Sun, Qingguo Wang, Huihua Qu
We have been looking for a faster and simpler method for traditional Chinese medicine and natural product assay. In this study, we developed a fluorescent immunoassay approach to detect icariin (ICA) using a fluorescently labelled monoclonal antibody. The ICA-specific antibody was purified by the caprylic acid-ammonium sulphate method and then labelled with rhodamine B isothiocyanate (RBITC). Subsequently, an indirect competitive fluorescence-linked immunosorbent assay (icFLISA) was developed to detect ICA using RBITC-labelled anti-ICA MAbs...
May 2, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28456078/significant-enhancement-by-biochar-of-caproate-production-via-chain-elongation
#15
Yuhao Liu, Pinjing He, Liming Shao, Hua Zhang, Fan Lü
In this study, biochar was introduced into a chain elongation system to enhance the bioproduction of caproate and caprylate. The concentration of caproate increased to 21.1 g/L upon the addition of biochar, which is the highest level of caproate reported for such a system to date when ethanol was used as electron donor. The addition of biochar created a tougher system with more stable microorganism community structure for chain elongation, in which no obvious inhibition by products or substrates was observed, moreover, the lag phase was reduced 2...
April 21, 2017: Water Research
https://www.readbyqxmd.com/read/28453979/effects-of-replacement-of-beef-fat-with-interesterified-palm-kernel-oil-on-the-quality-characteristics-of-turkish-dry-fermented-sausage
#16
Birol Kılıç, Cem Okan Özer
The objective of this study was to investigate the effects of replacing beef fat with enzymatic interesterified palm kernel oil (IPKO) on the quality characteristics and storage stability of sucuk (Turkish dry-fermented sausage). The partial (25, 50, 75%) and complete (100%) replacement of added beef fat with IPKO were carried out during sucuk processing. According to the study results, replacement of beef fat with IPKO resulted in significant increase in the concentrations of caprylic, capric, lauric and mryistic acid and decrease in the concentrations of stearic, oleic and linoleic acid in sucuk (P<0...
April 21, 2017: Meat Science
https://www.readbyqxmd.com/read/28396683/preparation-and-neutralization-efficacy-of-igy-antibodies-raised-against-deinagkistrodon-acutus-venom
#17
Jinhua Liu, Qiyi He, Wenwen Wang, Bin Zhou, Bo Li, Yingfeng Zhang, Cong Luo, Diancheng Chen, Jia Tang, Xiaodong Yu
BACKGROUND: The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses is the main treatment for snakebites, but it may cause numerous clinical side effects and have other disadvantages involved in their production such as the welfare of animals. The present study was conducted aiming to develop an alternative antibody (IgY) from the egg yolk of leghorn chickens immunized with snake venom...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28374734/-the-isolation-of-organic-compounds-from-hydrosulfuric-mineral-waters-with-the-use-of-the-extractive-freezing-out-technique-with-centrifugation
#18
V N Bekhterev, E A Kabina
The mineral waters, enriched with organic substances find extensive application in balneotherapy. The fast and efficient methods for the identification and quantitative measurement of organic compounds (in the first place, organic acids) in such waters need to be developed for the estimation of their quality and biological activity. AIM: The objective of the present study was to elaborate a gas chromatographic method for the determination of monobasic carbonic acids in sulfide-containing mineral waters by means of extractive freezing-out in combination with the application of the centrifugal forces for the elucidation of the metrological characteristics of the compounds of interest...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28367228/upgrading-syngas-fermentation-effluent-using-clostridium-kluyveri-in-a-continuous-fermentation
#19
Sylvia Gildemyn, Bastian Molitor, Joseph G Usack, Mytien Nguyen, Korneel Rabaey, Largus T Angenent
BACKGROUND: The product of current syngas fermentation systems is an ethanol/acetic acid mixture and the goal is to maximize ethanol recovery. However, ethanol currently has a relatively low market value and its separation from the fermentation broth is energy intensive. We can circumvent these disadvantages of ethanol production by converting the dilute ethanol/acetic acid mixture into products with longer carbon backbones, which are of higher value and are more easily extracted than ethanol...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28366804/effect-of-surfactant-chain-length-on-drug-release-kinetics-from-microemulsion-laden-contact-lenses
#20
Furqan A Maulvi, Ankita R Desai, Harsh H Choksi, Rahul J Patil, Ketan M Ranch, Bhavin A Vyas, Dinesh O Shah
The effect of surfactant chain lengths [sodium caprylate (C8), Tween 20 (C12), Tween 80 (C18)] and the molecular weight of block copolymers [Pluronic F68 and Pluronic F 127] were studied to determine the stability of the microemulsion and its effect on release kinetics from cyclosporine-loaded microemulsion-laden hydrogel contact lenses in this work. Globule size and dilution tests (transmittance) suggested that the stability of the microemulsion increases with increase in the carbon chain lengths of surfactants and the molecular weight of pluronics...
March 31, 2017: International Journal of Pharmaceutics
keyword
keyword
10313
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"