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Keywords adverse effects of Anti retrov...

adverse effects of Anti retroviral drugs

https://read.qxmd.com/read/38183393/prevalence-of-cytopenia-and-its-correlation-with-immunosuppression-in-na%C3%A3-ve-hiv-1-infected-patients-initiating-first-line-antiretroviral-therapy-a-pilot-study
#1
JOURNAL ARTICLE
Abdulrasheed Usman, Olayemi Balogun, Bukhari Isah Shuaib, Bolanle O P Musa, Aminu Abba Yusuf, Ebenezer I O Ajayi
BACKGROUND: Cytopenias serve as common indicators and crucial predictive tools for evaluating disease progression and therapeutic outcomes in individuals with human immunodeficiency virus (HIV) infection. This study aimed to assess the prevalence of cytopenias and their correlation with the level of immunosuppression in treatment-naive HIV-infected participants after initiating highly active combined antiretroviral drug therapy (cART24). MATERIALS AND METHODS: This prospective study focused on evaluating cytopenia in 44 treatment-naive HIV-infected patients who consented to initiate cART and were consecutively enrolled...
December 2023: Infection & Chemotherapy
https://read.qxmd.com/read/38116575/-it-is-not-easy-experiences-of-people-living-with-hiv-and-tuberculosis-on-tuberculosis-treatment-in-uganda
#2
JOURNAL ARTICLE
Ruth Nabisere-Arinaitwe, Lydia Namatende-Sakwa, Josephine Bayiga, Juliet Nampala, Lucy Alinaitwe, Florence Aber, Brian Otaalo, Joseph Musaazi, Rachel King, Mike Kesby, Derek J Sloan, Christine Sekaggya-Wiltshire
BACKGROUND: Completion of tuberculosis (TB) treatment presents several challenges to patients, including long treatment duration, medication adverse-effects and heavy pill burden. WHO emphasize the need for patient-centered TB care, but such approaches require understanding of patient experiences and perceptions. METHODS: In 2020, we nested a qualitative study within a clinical trial that recruited 128 HIV-TB co-infected adults in Kampala receiving rifampicin-based TB treatment, alongside anti-retroviral therapy...
December 2023: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://read.qxmd.com/read/38058002/efficacy-and-safety-of-bictegravir-emtricitabine-tenofovir-alafenamide-fumarate-for-adult-patients-with-human-immunodeficiency-virus-1-in-china-a-retrospective-real-world-cohort-study
#3
JOURNAL ARTICLE
Lin Gan, Xiaoxin Xie, Yanhua Fu, Yebing Song, Chunli Song, Tingting Ren, Hai Long
BACKGROUND: This study aimed to evaluate the therapeutic effect and tolerance of bictegravir/emtricitabine/tenofovir alafenamide fumarate (BIC/FTC/TAF) use for 24 weeks in anti-retroviral therapy (ART)-naïve patients in China. METHODS: This single-center retrospective cohort study included ART-naïve patients who received BIC/FTC/TAF from July 2021 to April 2022. The proportion of patients with HIV RNA < 50 copies/mL at the end point of 24 weeks (virological suppression rate) was the primary outcome, and the changes in CD4 cell count, CD4/CD8 ratio, weight, blood lipid, and safety were secondary outcomes...
December 6, 2023: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/37667777/hiv-aids-patients-knowledge-attitude-and-practice-toward-anti-retroviral-therapy-medications-adverse-effects-and-associated-factors-in-tikur-anbessa-specialized-hospital
#4
JOURNAL ARTICLE
Zenebe Negash, Yohannes Yibeltal, Akeberegn Gorems Ayele
BACKGROUND: Adverse effects (AEs) have been reported with all antiretroviral therapy (ART) medications, and it was among the most common cause for switching or terminating therapy and drug non-adherence. Even though AEs of ART medications are common and to be expected, little study has been conducted on the understanding of patients on the AEs. Therefore, this study aimed to assess patients' knowledge, attitude, and practice (KAP) toward ART medications' AEs and associated factors. METHODS: A cross-sectional study design was applied using an interviewer-administered questionnaire from June to September 2021 on human immunodeficiency virus/acquired immunodeficiency syndrome patients on follow-up at Tikur Anbessa Specialized Hospital, Ethiopia...
2023: Therapeutic Advances in Drug Safety
https://read.qxmd.com/read/37537596/withania-somnifera-extracts-induced-attenuation-of-hiv-1-a-mechanistic-approach-to-restrict-viral-infection
#5
JOURNAL ARTICLE
Pratiksha Jadaun, R Harshithkumar, Shraddha Y Gaikwad, Chandrabhan Seniya, Swapnil Borse, Ashish A Gawai, Preeti Chavan-Gautam, Girish Tillu, Anupam Mukherjee
BACKGROUND: Several anti-retroviral drugs are available against Human immunodeficiency virus type-1, but have multiple adverse side effects. Hence, there is an incessant compulsion for effectual anti-retroviral agents with minimal or no intricacy. Traditionally, natural products have been the most successful source for the development of new medications. Withania somnifera, also known as Ashwagandha, is the utmost treasured medicinal plant used in Ayurveda, which holds the potential to give adaptogenic, immunomodulatory, and antiviral effects...
August 3, 2023: Virology Journal
https://read.qxmd.com/read/37499393/relationship-between-interleukin-17-polymorphism-in-rs-2275913-and-rs-763780-and-interleukin-6-in-rs-1800795-gene-region-with-sensitivity-to-antiretroviral-drugs-in-patients-with-human-immunodeficiency-virus
#6
JOURNAL ARTICLE
Maryam Nejabat, Mohammad Motamedifar, Zohre Foroozanfar, Mohammadreza Heydari
Drug complication is still considered as one of the most important causes of death and drug in-compliance around the world. In this cross sectional study, 372 people living with HIV (PLHIV) above 16 years were enrolled. The drug complication was extracted based on the information of the patient's file. The molecular test was performed by the Restriction Fragment length polymorphism-Polymerase Chain Reaction method. Allelic frequency, haplotype analyses, linkage disequilibrium and odds ratio (OR) were calculated...
July 25, 2023: International Immunopharmacology
https://read.qxmd.com/read/37367032/development-and-in-house-validation-of-an-enzyme-linked-immunosorbent-assay-and-a-lateral-flow-immunoassay-for-the-dosage-of-tenofovir-in-human-saliva
#7
JOURNAL ARTICLE
Simone Cavalera, Thea Serra, Antonio Abad-Fuentes, Josep V Mercader, Antonio Abad-Somovilla, Fabio Di Nardo, Antonio D'Avolio, Amedeo De Nicolò, Valentina Testa, Matteo Chiarello, Claudio Baggiani, Laura Anfossi
Highly active antiretroviral therapy (HAART) includes very potent drugs that are often characterized by high toxicity. Tenofovir (TFV) is a widely used drug prescribed mainly for pre-exposure prophylaxis (PreP) and the treatment of human immunodeficiency virus (HIV). The therapeutic range of TFV is narrow, and adverse effects occur with both underdose and overdose. The main factor contributing to therapeutic failure is the improper management of TFV, which may be caused by low compliance or patient variability...
June 20, 2023: Biosensors
https://read.qxmd.com/read/37272234/a-korean-post-marketing-study-of-abacavir-dolutegravir-lamivudine-in-patients-with-hiv-1
#8
JOURNAL ARTICLE
Sang-Kyu Shin, Jung-Eun Cho, Eun-Bin Lee, Yeon-Sook Kim, Sook-In Jung
BACKGROUND: Abacavir/dolutegravir/lamivudine has been indicated in Korea since 2015 for treatment of human immunodeficiency virus type 1 (HIV-1) infection in combination. This regulatory post-marketing surveillance (PMS) study evaluated the real-life safety and effectiveness of abacavir/dolutegravir/lamivudine in patients with HIV-1 in clinical practice in Korea. MATERIALS AND METHODS: This open-label post-marketing surveillance examined data from consecutive patients (aged ≥12 years) with HIV-1 infection receiving abacavir/dolutegravir/lamivudine according to locally approved prescribing information; treatment-naïve and treatment-experienced patients were permitted...
May 4, 2023: Infection & Chemotherapy
https://read.qxmd.com/read/37266089/patterns-of-occupational-exposure-to-human-immunodeficiency-virus-and-post-exposure-prophylaxis-among-health-care-personnel-in-a-tertiary-care-institute-in-south-india-a-retrospective-case-series
#9
JOURNAL ARTICLE
M Vijaikumar, Saritha Mohanan, J Sowndharya, Carounanidy Udayashankar
BACKGROUND: Post-exposure prophylaxis (PEP) for occupational human immunodeficiency virus (HIV) exposure involves the comprehensive measures used to prevent transmission of blood-borne pathogens such as HIV, hepatitis B virus, and hepatitis C virus through various strategies such as first aid, counseling, risk assessment, relevant laboratory investigations with informed consent, the provision of short-term anti-retroviral drugs, and follow-up testing. AIM AND OBJECTIVES: We sought to investigate the patterns and causes of occupational exposure in health care workers (HCWs) in our institute and the usage of PEP in our center, a tertiary care hospital in south India...
2023: Indian Dermatology Online Journal
https://read.qxmd.com/read/36596681/a-korean-post-marketing-surveillance-study-of-dolutegravir-single-agent-tablets-in-patients-with-hiv-1
#10
JOURNAL ARTICLE
Sungshin Kwon, Jung-Eun Cho, Eun-Bin Lee, Yeon-Sook Kim, Jang-Wook Sohn
BACKGROUND: The integrase strand transfer inhibitor dolutegravir has been indicated in Korea since 2014 for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in combination with other antiretroviral agents. This regulatory post-marketing surveillance (PMS) study evaluated the real-life safety and effectiveness of dolutegravir in patients with HIV-1 in clinical practice in Korea. MATERIALS AND METHODS: This open-label PMS study examined data from consecutive patients (aged ≥12 years) with HIV-1 infection receiving dolutegravir according to locally approved prescribing information; treatment-naïve and treatment-experienced patients were permitted...
December 2022: Infection & Chemotherapy
https://read.qxmd.com/read/36042960/is-routine-therapeutic-drug-monitoring-of-anti-retroviral-agents-warranted-in-children-living-with-hiv
#11
JOURNAL ARTICLE
Jennifer Tam, Elaine Lau, Stanley Read, Ari Bitnun
OBJECTIVE: The utility of routine therapeutic drug monitoring (TDM) in children living with HIV has not been extensively studied. The purpose of this study was to assess this strategy. METHODS: This was a single-center, prospective observational study of routine TDM for protease inhibitors (PIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and integrase strand transfer inhibitors (INSTIs) in children living with HIV who were receiving antiretroviral therapy (ART) between February and December 2014...
2022: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/35550020/quality-of-life-and-associated-factors-among-people-receiving-second-line-anti-retroviral-therapy-in-johannesburg-south-africa
#12
JOURNAL ARTICLE
Nomcebo Oratile Mokgethi, Nicola Christofides, Mercilene Machisa, Godspower Akpomiemie, Samantha Lalla-Edward
BACKGROUND: Studies which examine quality of life (QOL) provide important insights that are needed to understand the impacts of HIV/AIDS anti-retroviral treatment (ART), comorbid conditions and other factors on the daily activities of people living with HIV/AIDS (PLH). This study aimed to determine the inter-relationships between clinical factors, behavioural, socio-demographic variables and QOL among PLH. METHODS: The secondary analysis used data collected from 293 people living with HIV/AIDS (PLH) receiving second-line ART in Johannesburg in a clinical trial which evaluated the non-inferiority of ritonavir-boosted darunavir (DRV/r 400/100 mg) compared to ritonavir-boosted lopinavir (LPV/r) over a 48 week-period...
May 12, 2022: BMC Infectious Diseases
https://read.qxmd.com/read/35037450/the-prevalence-and-pattern-of-thyroid-dysfunction-in-haart-na%C3%A3-ve-hiv-patients-in-enugu-nigeria-a-cross-sectional-comparative-study
#13
JOURNAL ARTICLE
C V Ugwueze, E E Young, C N Unachukwu, B M Onyenekwe, C B Nwatu, C I Okafor, C M Ezeude, B C Ezeokpo
BACKGROUND: HIV/AIDS is a multi-system disease that has been associated with several endocrinopathies including thyroid dysfunction. Thyroid dysfunction in patients with HIV/AIDS, among other factors, may arise from the direct cytopathic effects of HIV on the thyroid gland in addition to the adverse effects of highly active anti-retroviral drugs (HAART). STUDY OBJECTIVE: The study aimed to determine the prevalence and pattern of thyroid dysfunction in HAART naïve HIV patients in Enugu...
December 30, 2021: West African Journal of Medicine
https://read.qxmd.com/read/34876050/provider-perspectives-on-the-acceptability-and-tolerability-of-dolutegravir-based-anti-retroviral-therapy-after-national-roll-out-in-uganda-a-qualitative-study
#14
JOURNAL ARTICLE
Henry Zakumumpa, Freddy Eric Kitutu, Helen Byomire Ndagije, Nakitto-Kesi Diana, Jacquellyn Nambi Ssanyu, Ronald Kiguba
BACKGROUND: The World Health Organization recommends dolutegravir (DTG) as the for first-line and second-line antiretroviral therapy (ART) worldwide. However, little is known about the acceptability and tolerability of DTG-based ART at routine points-of-care in Uganda. We set out to explore the perceptions of clinicians in ART clinics regarding the acceptability and tolerability of DTG-based ART since national roll-out in March 2018 in Uganda. METHODS: We adopted a qualitative exploratory design involving 49 participants...
December 7, 2021: BMC Infectious Diseases
https://read.qxmd.com/read/34832897/hiv-1-protease-and-reverse-transcriptase-inhibitory-activities-of-curcuma-aeruginosa-roxb-rhizome-extracts-and-the-phytochemical-profile-analysis-in-vitro-and-in-silico-screening
#15
JOURNAL ARTICLE
Chanin Sillapachaiyaporn, Panthakarn Rangsinth, Sunita Nilkhet, Nuntanat Moungkote, Siriporn Chuchawankul
Human immunodeficiency virus type-1 (HIV-1) infection causes acquired immunodeficiency syndrome (AIDS). Currently, several anti-retroviral drugs are available, but adverse effects of these drugs have been reported. Herein, we focused on the anti-HIV-1 activity of Curcuma aeruginosa Roxb. (CA) extracted by hexane (CA-H), ethyl acetate (CA-EA), and methanol (CA-M). The in vitro HIV-1 protease (PR) and HIV-1 reverse transcriptase (RT) inhibitory activities of CA extracts were screened. CA-M potentially inhibited HIV-1 PR (82...
October 31, 2021: Pharmaceuticals
https://read.qxmd.com/read/34515794/dolutegravir-impairs-stem-cell-based-3d-morphogenesis-models-in-a-manner-dependent-on-dose-and-timing-of-exposure-an-implication-for-its-developmental-toxicity
#16
JOURNAL ARTICLE
Lauren Kirkwood-Johnson, Nana Katayama, Yusuke Marikawa
Dolutegravir (DTG) is an antiretroviral drug of the integrase strand transfer inhibitor (INSTI) class used to treat human immunodeficiency virus infection. It is the recommended first-line regimen for most people, including women of childbearing age. However, some human and animal studies have suggested that DTG causes birth defects, although its developmental toxicity remains controversial. Here, we investigated the adverse effects of DTG using pluripotent stem cell-based in vitro morphogenesis models that have previously been validated as effective tools to assess the developmental toxicity of various chemicals...
November 24, 2021: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/34118364/haart-exacerbates-testicular-damage-and-impaired-spermatogenesis-in-anti-koch-treated-rats-via-dysregulation-of-lactate-transport-and-glutathione-content
#17
JOURNAL ARTICLE
R E Akhigbe, M A Hamed, A O Aremu
Highly active anti-retroviral therapy (HAART) is an effective anti-retroviral cocktail. Similarly, anti-Koch is highly potent against Mycobacterium tuberculosis. However, these drugs have been shown to impair male fertility. This study investigated the impact of HAART and anti-Koch, when used alone and co-administered, on testicular and sperm integrity. Thirty-two adult male Wistar rats were assigned randomly into four groups (n = 8), namely normal control, HAART-treated, anti-Koch-treated, and HAART + anti-Koch-treated...
August 2021: Reproductive Toxicology
https://read.qxmd.com/read/34043687/incidence-and-predictors-of-adverse-drug-reaction-adr-among-adult-hiv-positive-patients-on-anti-retroviral-treatment-in-arba-minch-town-public-health-facilities-southern-ethiopia-a-retrospective-cohort-study-2020
#18
JOURNAL ARTICLE
Abdulbasit Sherfa, Dereje Haile, Menaye Yihune, Sewenet Sako
BACKGROUND: Besides its contribution in the treatment of Human Immunodeficiency Virus-infected patients, anti-retroviral drugs may also cause mild to serious adverse effects. It is the main causes for poor drug adherence, treatment discontinuation and changes in Anti-Retroviral Treatment (ART) regimens. Thus, the aim of this study was to assess the incidence and predictors of adverse drug reaction among adult Human Immunodeficiency Virus positive patients on anti-retroviral treatment from January 1, 2013 up to December 30, 2018 at Arba Minch town public health facilities, Southern Ethiopia...
2021: PloS One
https://read.qxmd.com/read/33681293/neurological-consequences-of-sars-cov-2-infection-and-concurrence-of-treatment-induced-neuropsychiatric-adverse-events-in-covid-19-patients-navigating-the-uncharted
#19
REVIEW
Pobitra Borah, Pran Kishore Deb, Balakumar Chandrasekaran, Manoj Goyal, Monika Bansal, Snawar Hussain, Pottathil Shinu, Katharigatta N Venugopala, Nizar A Al-Shar'i, Satyendra Deka, Vinayak Singh
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor and invade the human cells to cause COVID-19-related pneumonia. Despite an emphasis on respiratory complications, the evidence of neurological manifestations of SARS-CoV-2 infection is rapidly growing, which is substantially contributing to morbidity and mortality. The neurological disorders associated with COVID-19 may have several pathophysiological underpinnings, which are yet to be explored...
2021: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/33507945/comparison-of-different-cardiovascular-risk-tools-used-in-hiv-patient-cohorts-in-sub-saharan-africa-do-we-need-to-include-laboratory-tests
#20
JOURNAL ARTICLE
Frank Mubiru, Barbara Castelnuovo, Steven J Reynolds, Agnes Kiragga, Harriet Tibakabikoba, Noela Clara Owarwo, Andrew Kambugu, Mohammed Lamorde, Rosalind Parkes-Ratanshi
INTRODUCTION: Cardiovascular disease (CVD) is the leading cause of death globally, representing 31% of all global deaths. HIV and long term anti-retroviral therapy (ART) are risk factors for development of CVD in populations of people living with HIV (PLHIV). CVD risk assessment tools are currently being applied to SSA populations, but there are questions about accuracy as well as implementation challenges of these tools in lower resource setting populations. We aimed to assess the level of agreement between the various cardiovascular screening tools (Data collection on Adverse effects of anti-HIV Drugs (D:A:D), Framingham risk score, WHO risk score and The Atherosclerotic Cardiovascular Disease Score) when applied to an HIV ART experienced population in Sub-Saharan Africa...
2021: PloS One
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