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adverse effects of ART

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https://www.readbyqxmd.com/read/28922422/psychological-effects-of-the-intensified-follow-up-of-the-ceawatch-trial-after-treatment-for-colorectal-cancer
#1
Zhuozhao Zhan, Charlotte J Verberne, Edwin R van den Heuvel, Irene Grossmann, Adelita V Ranchor, Theo Wiggers, Geertruida H de Bock
BACKGROUND: The aim of the study was to evaluate psychological effects of the state-of-art intensified follow-up protocol for colorectal cancer patients in the CEAwatch trial. METHOD: At two time points during the CEAwatch trial questionnaires regarding patients' attitude towards follow-up, patients' psychological functioning and patients' experiences and expectations were sent to participants by post. Linear mixed models were fitted to assess the influences and secular trends of the intensified follow-up on patients' attitude towards follow-up and psychological functioning...
2017: PloS One
https://www.readbyqxmd.com/read/28915327/adipose-tissue-in-hiv-infection
#2
John R Koethe
HIV infection and antiretroviral therapy (ART) treatment exert diverse effects on adipocytes and stromal-vascular fraction cells, leading to changes in adipose tissue quantity, distribution, and energy storage. A HIV-associated lipodystrophic condition was recognized early in the epidemic, characterized by clinically apparent changes in subcutaneous, visceral, and dorsocervical adipose depots. Underlying these changes is altered adipose tissue morphology and expression of genes central to adipocyte maturation, regulation, metabolism, and cytokine signaling...
September 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28903940/secondary-open-aortic-procedure-following-thoracic-endovascular-aortic-repair-meta-analytic-state-of-the-art
#3
REVIEW
Ivancarmine Gambardella, George A Antoniou, Francesco Torella, Cristiano Spadaccio, Aung Y Oo, Mario Gaudino, Francesco Nappi, Matthew A Shaw, Leonard N Girardi
BACKGROUND: Thoracic endovascular aortic repair is characterized by a substantial need for reintervention. Secondary open aortic procedure becomes necessary when further endoluminal options are exhausted. This synopsis and quantitative analysis of available evidence aims to overcome the limitations of institutional cohort reports on secondary open aortic procedure. METHODS AND RESULTS: Electronic databases were searched from 1994 to the present date with a prospectively registered protocol...
September 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28888499/the-efficacy-of-art-therapy-in-pediatric-oncology-patients-an-integrative-literature-review
#4
REVIEW
Bree A Aguilar
PROBLEM: Children undergoing cancer treatment experience detrimental adverse side effects that may be addressed with complementary and alternative medicine (CAM) such as art therapy. The purpose of this research was to examine the effects of art therapy in pediatric patients living with cancer. ELIGIBILITY CRITERIA: An integrative literature review was conducted using the CINAHL, OVID Medline, and PsycINFO databases. Studies were included if they were a primary source utilizing an art therapy intervention in children with cancer age birth to 18years old, was published between the year 2000 and 2016, and written in the English language...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28870263/effect-of-maternal-vitamin-d3-supplementation-on-maternal-health-birth-outcomes-and-infant-growth-among-hiv-infected-tanzanian-pregnant-women-study-protocol-for-a-randomized-controlled-trial
#5
Christopher R Sudfeld, Karim P Manji, Christopher P Duggan, Said Aboud, Alfa Muhihi, David M Sando, Fadhlun M Alwy Al-Beity, Molin Wang, Wafaie W Fawzi
BACKGROUND: Vitamin D has significant immunomodulatory effects on both adaptive and innate immune responses. Observational studies indicate that adults infected with HIV with low vitamin D status may be at increased risk of mortality, pulmonary tuberculosis, and HIV disease progression. Growing observational evidence also suggests that low vitamin D status in pregnancy may increase the risk of adverse birth and infant health outcomes. As a result, antiretroviral therapy (ART) adjunct vitamin D3 supplementation may improve the health of HIV-infected pregnant women and their children...
September 4, 2017: Trials
https://www.readbyqxmd.com/read/28864984/the-importance-of-the-periconception-period-immediate-effects-in-cattle-breeding-and-in-assisted-reproduction-such-as-artificial-insemination-and-embryo-transfer
#6
Mieke Van Eetvelde, Sonia Heras, J L M R Leroy, Ann Van Soom, Geert Opsomer
In livestock breeding, the successful outcome is largely depending on the "periconception environment" which, in a narrow sense, refers to the genital tract, where gametogenesis and embryogenesis occur. During these early stages of development, gametes and embryos are known to be particularly sensitive to alterations in their microenvironment. However, as the microenvironment somehow reflects what is going on in the external world, we must widen our definition of "periconception environment" and refer to all events taking place around the time of conception, including metabolic state and health and nutrition of the dam...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28861691/post-prostatectomy-radiotherapy-adversely-affects-urinary-continence-irrespective-of-radiotherapy-regime
#7
J N Nyarangi-Dix, J Steimer, T Bruckner, H Jakobi, S A Koerber, B Hadaschik, J Debus, M Hohenfellner
PURPOSE: To investigate the influence of different postoperative radiotherapy (RT) regimes on post-prostatectomy continence and QoL. METHODS: Men after prostatectomy (RP) and RT were assigned in adjuvant (ART), early salvage (ESRT) and salvage radiotherapy (SRT) groups depending on time of initiation, indication and pre-RT-PSA (≤/>0.5 ng/ml). Continence and QoL outcomes were evaluated by validated questionnaire. Statistical analysis included students t test, Chi square, Fisher's test, ROC- and McNemar-Bowker-Analyses...
August 31, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28859681/factors-affecting-affect-cardiovascular-health-in-indonesian-hiv-patients-beginning-art
#8
Birry Karim, Ika Praseya Wijaya, Rizky Rahmaniyah, Ibnu Ariyanto, Shelley Waters, Riwanti Estiasari, Patricia Price
BACKGROUND: We present a small longitudinal study of how demographic factors and persistent burdens of HIV and cytomegalovirus (CMV) influence cardiovascular health in young adults beginning ART in an inner-city clinic in Jakarta, Indonesia. METHODS: ART-naïve HIV patients [n = 67; aged 31 (19 to 48) years] were enrolled in the JakCCANDO Project. Echocardiography and carotid Doppler ultrasonography were performed before ART (V0) and after 3, 6, and 12 months (V3-12)...
August 31, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28856695/association-between-body-mass-index-and-sperm-quality-and-sperm-dna-integrity-a-large-population-study
#9
J B A Oliveira, C G Petersen, A L Mauri, L D Vagnini, A Renzi, B Petersen, M Mattila, F Dieamant, R L R Baruffi, J G Franco
This study aimed to analyse whether the functional quality of spermatozoa is associated with body mass index (BMI). Semen samples were obtained from 1824 men undergoing fertility evaluation/treatment. Semen analysis was performed using World Health Organization (WHO) criteria, and morphology was evaluated with the motile sperm organelle morphology examination (MSOME). The percentages of sperm DNA fragmentation (using TdT (terminal deoxynucleotidyl transferase)-mediated dUTP nick-end labelling (TUNEL) assays), sperm chromatin packaging/underprotamination (using chromomycin A3/CMA3 ), mitochondrial damage (using MitoTracker Green) and apoptosis (using annexin V) were also assessed...
August 30, 2017: Andrologia
https://www.readbyqxmd.com/read/28854726/the-association-between-pre-treatment-maternal-alcohol-and-caffeine-intake-and-outcomes-of-assisted-reproduction-in-a-prospectively-followed-cohort
#10
L Abadia, Y-H Chiu, P L Williams, T L Toth, I Souter, R Hauser, J E Chavarro, A J Gaskins
STUDY QUESTION: Is pre-treatment alcohol and caffeine intake associated with infertility treatment outcomes among women undergoing ART? SUMMARY ANSWER: Low to moderate alcohol and caffeine intakes in the year prior to infertility treatment were not related to ART outcomes. WHAT IS KNOWN ALREADY: Alcohol and caffeine intake have been found to be associated with infertility in some studies. Nevertheless, data on their relation with outcomes of infertility treatments are scarce and inconsistent...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28840094/the-risk-benefit-ratio-of-glucocorticoids-in-sle-have-things-changed-over-the-past-40-years
#11
G Stojan, M Petri
PURPOSE OF REVIEW: Glucocorticoids have been the mainstay of treatment in systemic lupus erythematosus for more than half a century. Despite advancements in knowledge concerning the pathophysiology of systemic lupus, the genomic/non-genomic actions of glucocorticoids, and the use of novel therapeutic agents in SLE, the burden of toxicity from glucocorticoid use remains unchanged. RECENT FINDINGS: SLE patients receiving long-term prednisone therapy are at significant risk of morbidity due to permanent organ damage and prednisone daily dosages above 6 mg have been shown to increase the risk of future organ damage by 50%...
September 2017: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/28836468/effectiveness-safety-and-costs-of-a-treatment-switch-to-dolutegravir-plus-rilpivirine-dual-therapy-in-treatment-experienced-hiv-patients
#12
José Luis Revuelta-Herrero, Esther Chamorro-de-Vega, Carmen Guadalupe Rodríguez-González, Roberto Alonso, Ana Herranz-Alonso, María Sanjurjo-Sáez
BACKGROUND: Evidence about the use of dolutegravir (DTG) and rilpivirine (RPV) as an antiretroviral therapy (ART) in treatment-experienced patients is scarce. OBJECTIVE: To explore the effectiveness, safety, and costs of switching to a DTG plus RPV regimen in this population. METHODS: This observational, prospective study included all treatment-experienced patients who switched to DTG plus RPV between November 2014 and July 2016. Patients were excluded if resistance mutations to integrase inhibitors or RPV were found...
August 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28826735/rapid-cd4-decline-prior-to-antiretroviral-therapy-predicts-subsequent-failure-to-reconstitute-despite-hiv-viral-suppression
#13
Majid Darraj, Leigh Anne Shafer, Shanna Chan, Ken Kasper, Yoav Keynan
HIV-1 infection is characterized by loss of CD4T cells, leading to immunodeficiency. Initiation of antiretroviral therapy (ART) results in suppression of the viral load and increased CD4 counts. Both viral and host factors determine CD4 cell responses to ART with approximately 15-30% of individuals having suboptimal increase of CD4T cell count, most commonly due to lack of compliance to ART. A smaller fraction of patients will have immune reconstitution failure and suboptimal CD4 increase despite suppression of HIV replication, and these individuals are at risk for adverse health outcomes...
August 18, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28815718/a-potential-high-risk-for-fatty-liver-disease-was-found-in-mice-generated-after-assisted-reproductive-techniques
#14
Leilei Gu, Jingjing Zhang, Meimei Zheng, Guoying Dong, Jingyi Xu, Wuyue Zhang, Yibo Wu, Yang Yang, Hui Zhu
Abnormal gametogenesis and embryonic development may lead to poor health status of the offspring. The operations involved in the assisted reproductive technologies (ARTs) occur during the key stage of gametogenesis and early embryonic development. To assess the potential risk of abnormal lipid metabolism in the liver of adult ARTs offspring, two ARTs mice models derived from preimplantation genetic diagnosis (PGD group) and in vitro cultured embryos without biopsy (IVEM group) were constructed. And control mice were from in vivo naturally conceived (Normal group)...
August 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28792168/indian-adolescent-living-with-hiv-aids-current-clinical-scenario
#15
Kavita S Joshi, Bhushan D Bhaware, Amar R Pazare
INTRODUCTION: Statistics suggest that, HIV has now largely become the disease of young patients. Hence, the adolescent HIV/AIDS needs to be handled and managed separately from adult HIV. Relatively fewer Indian data exist to characterize the associations in adolescents and young adults infected with HIV disease. The present study explores the current challenges in the management of HIV infected adolescents. OBJECTIVE: The study was aimed at evaluating, relationship between CD4 count and duration of antiretroviral therapy (ART), effects of ART on body mass index and the adverse effects of antiretroviral drugs in adolescent HIV positive patients...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28774548/safety-and-efficiency-of-oocyte-vitrification
#16
REVIEW
Neelke De Munck, Gábor Vajta
As the oocyte is the starting point for a new life, artificial reproductive technology (ART) techniques should not affect the (ultra) structural and functional integrity, or the developmental competence. Oocyte vitrification -one of the most significant achievements in human ART during the past decade- should therefore be a safe and efficient technique. This review discusses the principles and developments of the existing and future techniques, applications possibilities and safety concerns. The broad range of vitrification media and devices that are currently available, show differences in their effects on the oocyte ultrastructure and preimplantation development...
August 1, 2017: Cryobiology
https://www.readbyqxmd.com/read/28770596/high-rates-of-viral-suppression-in-adults-and-children-with-high-cd4-counts-using-a-streamlined-art-delivery-model-in-the-search-trial-in-rural-uganda-and-kenya
#17
Dalsone Kwarisiima, Moses R Kamya, Asiphas Owaraganise, Florence Mwangwa, Dathan M Byonanebye, James Ayieko, Albert Plenty, Doug Black, Tamara D Clark, Bridget Nzarubara, Katherine Snyman, Lillian Brown, Elizabeth Bukusi, Craig R Cohen, Elvin H Geng, Edwin D Charlebois, Theodore D Ruel, Maya L Petersen, Diane Havlir, Vivek Jain
INTRODUCTION: The 2015 WHO recommendation of antiretroviral therapy (ART) for all HIV-positive persons calls for treatment initiation in millions of persons newly eligible with high CD4+ counts. Efficient and effective care models are urgently needed for this population. We evaluated clinical outcomes of asymptomatic HIV-positive adults and children starting ART with high CD4+ counts using a novel streamlined care model in rural Uganda and Kenya. METHODS: In the 16 intervention communities of the HIV test-and-treat Sustainable East Africa Research for Community Health Study (NCT01864603), all HIV-positive individuals irrespective of CD4 were offered ART (efavirenz [EFV]/tenofovir disoproxil fumarate + emtricitabine (FTC) or lamivudine (3TC)...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28756654/adverse-effect-of-superovulation-treatment-on-maturation-function-and-ultrastructural-integrity-of-murine-oocytes
#18
Myungook Lee, Jong Il Ahn, Ah Ran Lee, Dong Woo Ko, Woo Sub Yang, Gene Lee, Ji Yeon Ahn, Jeong Mook Lim
Regular monitoring on experimental animal management found the fluctuation of ART outcome, which showed a necessity to explore whether superovulation treatment is responsible for such unexpected outcome. This study was subsequently conducted to examine whether superovulation treatment can preserve ultrastructural integrity and developmental competence of oocytes following oocyte activation and embryo culture. A randomized study using mouse model was designed and in vitro development (experiment 1), ultrastructural morphology (experiment 2) and functional integrity of the oocytes (experiment 3) retrieved after PMSG/hCG injection (superovulation group) or not (natural ovulation; control group) were evaluated...
August 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28749739/nanomedicine-formulations-for-the-delivery-of-antiviral-drugs-a-promising-solution-for-the-treatment-of-viral-infections
#19
David Lembo, Manuela Donalisio, Andrea Civra, Monica Argenziano, Roberta Cavalli
Viral infections represent a public health problem and one of the leading causes of global mortality. Nanomedicine strategies can be considered a powerful tool to enhance the effectiveness of antiviral drugs, often associated with solubility and bioavailability issues. Consequently, high doses and frequent administrations are required, resulting in adverse side effects. To overcome these limitations, various nanomedicine platforms have been designed. Area covered. This review focuses on the state of the art of organic-based nanoparticles for the delivery of approved antivirals...
July 27, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28732306/photostability-testing-using-online-reactor-hplc-hyphenation-and-mass-spectrometric-compound-identification-illustrated-by-ketoprofen-as-model-compound
#20
Jaber Assaf, Diego Zulkiewicz Gomes, Bernhard Wuest, Maria Kristina Parr
Investigations on the photochemical stability of pharmaceutical substances are mandatory in drug development and licensing as photo-induced degradation of an active pharmaceutical ingredient (API) may not only lead to decreased API concentrations but also to toxic or reactive products. Thus, the US Food and Drug Administration (FDA) and the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) issued Guidance for Industry Q1B "Photostability Testing of New Drug Substances and Products" for testing of pure but also packed drugs...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
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