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Citicoline AND Glaucoma

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https://www.readbyqxmd.com/read/27581256/commentary-citicoline-a-food-beneficial-for-patients-suffering-from-or-threated-with-glaucoma
#1
COMMENT
Vincenzo Parisi, Lucia Ziccardi, Gloria Roberti, Lucia Tanga, Gianluca Manni
No abstract text is available yet for this article.
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27092075/citicoline-a-food-beneficial-for-patients-suffering-from-or-threated-with-glaucoma
#2
REVIEW
Pawel Grieb, Anselm Jünemann, Marek Rekas, Robert Rejdak
Oral form of citicoline, a nootropic and neuroprotective drug in use for almost five decades, recently was pronounced a food supplement in both USA and EU. The idea of adding citicoline to topical treatment of primary open angle glaucoma (POAG) aimed at decreasing intraocular pressure (IOP) appeared as a logical consequence of accepting neurodegenerative character of this disease. Experimental data, and also few clinical studies indicate that this substance has potential to counteract some important pathological mechanisms which seem to contribute to POAG initiation and progression, such as excitotoxicity and oxidative stress...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/26979720/citicoline-retards-myopia-progression-following-form-deprivation-in-guinea-pigs
#3
Junfeng Mao, Shuangzhen Liu, Chunyan Fu
The retinal dopaminergic system is involved in the myopic shift following form deprivation. Citicoline has been demonstrated to stimulate the dopaminergic system in the brain and retina. Furthermore, citicoline has been used in many neurogenic diseases, such as senile cognitive impairment, stroke and Parkinson's disease as well as in amblyopia and glaucoma. Our aim was to investigate the effect of citicoline on the refractive state and retinal dopamine level in form deprivation myopia of guinea pigs. Guinea pigs, at an age of four weeks, were randomly divided into normal control, deprivation, deprived + citicoline and deprived + vehicle groups...
June 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/26633368/cytidine-5-diphosphocholine-citicoline-in-glaucoma-rationale-of-its-use-current-evidence-and-future-perspectives
#4
REVIEW
Gloria Roberti, Lucia Tanga, Manuele Michelessi, Luciano Quaranta, Vincenzo Parisi, Gianluca Manni, Francesco Oddone
Cytidine 5'-diphosphocholine or citicoline is an endogenous compound that acts in the biosynthetic pathway of phospholipids of cell membranes, particularly phosphatidylcholine, and it is able to increase neurotrasmitters levels in the central nervous system. Citicoline has shown positive effects in Parkinson's disease and Alzheimer's disease, as well as in amblyopia. Glaucoma is a neurodegenerative disease currently considered a disease involving ocular and visual brain structures. Neuroprotection has been proposed as a valid therapeutic option for those patients progressing despite a well-controlled intraocular pressure, the main risk factor for the progression of the disease...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26004075/treatment-with-citicoline-eye-drops-enhances-retinal-function-and-neural-conduction-along-the-visual-pathways-in-open-angle-glaucoma
#5
RANDOMIZED CONTROLLED TRIAL
Vincenzo Parisi, Marco Centofanti, Lucia Ziccardi, Lucia Tanga, Manuele Michelessi, Gloria Roberti, Gianluca Manni
PURPOSE: To evaluate the retinal function and the neural conduction along the visual pathways after treatment with citicoline eye drops in patients with open angle glaucoma (OAG). METHODS: Fifty-six OAG patients (mean age 52.4 ± 4.72 years, IOP <18 mmHg with beta-blocker monotherapy only) were enrolled. Of these, 47 eyes completed the study: 24 OAG eyes were treated with topical citicoline (OMK1®, Omikron Italia, 3 drops/day) (GC eyes) over a 4-month period (month 4) followed by a 2-month period of citicoline wash-out (month 6), and another 23 OAG eyes were only treated with beta-blocker monotherapy (GP eyes)...
August 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/24881599/a-preliminary-study-of-the-neuroprotective-role-of-citicoline-eye-drops-in-glaucomatous-optic-neuropathy
#6
Gloria Roberti, Lucia Tanga, Vincenzo Parisi, Massimo Sampalmieri, Marco Centofanti, Gianluca Manni
PURPOSE: To study the neuroprotective effect of topical citicoline. MATERIALS AND METHODS: Experimental phase to evaluate the ability of citicoline eye drops to reach the vitreous and the retina: The right eyes of 5 mice CD1 were treated with two drops per day for three days of citicoline 1% and 2% (OMK1, Omikron Italia s.r.l.), and then the vitreous was analyzed with the liquid chromatography and spectrometry mass (LC-MS/MS). Clinical phase to determine if topical citicoline is able to delay glaucoma progression, considering perimetric parameters and electro functional tests...
May 2014: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/24504829/neuroprotective-properties-of-citicoline-facts-doubts-and-unresolved-issues
#7
REVIEW
Pawel Grieb
Citicoline is the generic name of the pharmaceutical substance that chemically is cytidine-5'-diphosphocholine (CDP-choline), which is identical to the natural intracellular precursor of phospholipid phosphatidylcholine. Following injection or ingestion, citicoline is believed to undergo quick hydrolysis and dephosphorylation to yield cytidine and choline, which then enter the brain separately and are used to resynthesize CDP-choline inside brain cells. Neuroprotective activity of citicoline has been repeatedly shown in preclinical models of brain ischaemia and trauma, but two recent, large, pivotal clinical trials have revealed no benefits in ischaemic stroke and traumatic brain injury...
March 2014: CNS Drugs
https://www.readbyqxmd.com/read/23615390/citicoline-oral-solution-in-glaucoma-is-there-a-role-in-slowing-disease-progression
#8
RANDOMIZED CONTROLLED TRIAL
L Ottobelli, G L Manni, M Centofanti, M Iester, F Allevena, L Rossetti
PURPOSE: To assess the effect of citicoline on visual field rates of progression in patients with progressing glaucoma. PATIENTS AND METHODS: Forty-one patients with a diagnosis of progressing glaucoma received citicoline in oral solution for 2 years. Included were patients with a disease progression of at least -1 dB/year (at MD, mean deviation) for at least 3 years before entering the study despite controlled intraocular pressure (IOP). Patients were followed with 4 visual field examinations per year for 2 years...
2013: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/22994104/-markers-of-fas-mediated-apoptosis-in-primary-open-angle-glaucoma-and-opportunities-of-their-pharmacological-correction
#9
O S Slepova, M A Frolov, N S Morozova, A M Frolov, Dzh N Lovpache
In order to assess the role of apoptosis in pathogenesis of primary open-angle glaucoma (POAG) apoptosis markers were studied in blood serum and tear fluid of patients with or suspected to have different stages glaucoma. To date the study of POAC pathogenesis goes along with search of possible ways of pharmacotherapy, neuroprotection is considered to be a promising option. Dynamics of sFas/Apo-1 and sFasL as the markers of Fas-mediated apoptosis was studied during treatment. We used nootropic citicoline as a neuroprotector...
July 2012: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/22370760/morphometric-analyses-of-retinal-sections
#10
Tin Fung Chan, Kin Chiu, Carmen Ka Ming Lok, Ho Wing Lau, Kwok-Fai So, Raymond Chuen-Chung Chang
Morphometric analyses of retinal sections have been used in examining retinal diseases. For examples, neuronal cells were significantly lost in the retinal ganglion cell layer (RGCL) in rat models with N-methyl-D-aspartate (NMDA)-induced excitotoxicity(1), retinal ischemia-reperfusion injury(2) and glaucoma(3). Reduction of INL and inner plexiform layer (IPL) thicknesses were reversed with citicoline treatment in rats' eyes subjected to kainic acid-mediated glutamate excitotoxicity(4). Alteration of RGC density and soma sizes were observed with different drug treatments in eyes with elevated intraocular pressure(3,5,6)...
2012: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/22165093/-the-effect-of-parenteral-citicoline-on-visual-functions-and-life-quality-of-patients-with-primary-open-angle-glaucoma
#11
M A Frolov, P A Gonchar, V I Barashkov, V Kumar, N S Morozova, A M Frolov, K A Kazakova
The effect of nootropic drug citicoline on visual functions, perimetric indexes of static automated perimetry, morphometric characteristics of retinal tomography and life quality of patients with primary open-angle glaucoma (POAG) stage I-III and normalized intraocular pressure (IOP) was studied. 40 patients aged 46-78 years old with POAG stage I-III and normalized IOP were treated with citicoline. Among them there were 24 female and 16 male. The patients were divided into 2 equal groups--experimental and control...
September 2011: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/19122569/citicoline-update-on-a-promising-and-widely-available-agent-for-neuroprotection-and-neurorepair
#12
REVIEW
Jeffrey L Saver
Choline precursors promote repair and growth of cell membranes and hold promise in a variety of neurologic diseases, including ischemic and hemorrhagic stroke. Citicoline, the most well-studied choline agent precursor, is widely prescribed throughout the world and recently became available in the United States as a dietary supplement. In experimental stroke models, citicoline conferred acute neuroprotection and enhanced neuroplasticity and neurorepair in the subacute period. Although individual human stroke trials have been inconclusive, meta-analysis of 10 trials enrolling 2279 patients suggests patients receiving citicoline had substantially reduced frequencies of death and disability...
2008: Reviews in Neurological Diseases
https://www.readbyqxmd.com/read/18929133/evidence-of-the-neuroprotective-role-of-citicoline-in-glaucoma-patients
#13
Vincenzo Parisi, Giovanni Coppola, Marco Centofanti, Francesco Oddone, Anna Maria Angrisani, Lucia Ziccardi, Benedetto Ricci, Luciano Quaranta, Gianluca Manni
The glaucomatous disease is currently considered a disease involving ocular and visual brain structures. This new approach to glaucoma introduces the possibility of inducing an improvement by means of a pharmacological approach similar to that used in different degenerative brain disorders. In line with this hypothesis, we studied the effects of oral (1600 mg/die, Cebrolux, Tubilux Pharma, Pomezia, Rome, Italy) or intramuscular (1000 mg/die, Cebroton, Tubilux Pharma) cytidine-5'-diphosphocholine (citicoline) treatment on retinal function and neural conduction in the visual pathways of glaucoma patients with moderate visual defects...
2008: Progress in Brain Research
https://www.readbyqxmd.com/read/18377103/citicoline-monograph
#14
(no author information available yet)
No abstract text is available yet for this article.
March 2008: Alternative Medicine Review: a Journal of Clinical Therapeutic
https://www.readbyqxmd.com/read/17171187/citicoline-pharmacological-and-clinical-review-2006-update
#15
REVIEW
Julio J Secades, José Luis Lorenzo
Cytidine 5'-diphosphocholine, CDP-choline, or citicoline is an essential intermediate in the biosynthetic pathway of structural phospholipids in cell membranes, particularly phosphatidylcholine. Following administration by both the oral and parenteral routes, citicoline releases its two main components, cytidine and choline. Absorption by the oral route is virtually complete, and bioavailability by the oral route is therefore approximately the same as by the intravenous route. Once absorbed, citicoline is widely distributed throughout the body, crosses the blood-brain barrier and reaches the central nervous system (CNS), where it is incorporated into the membrane and microsomal phospholipid fraction...
September 2006: Methods and Findings in Experimental and Clinical Pharmacology
https://www.readbyqxmd.com/read/16249960/electrophysiological-assessment-of-glaucomatous-visual-dysfunction-during-treatment-with-cytidine-5-diphosphocholine-citicoline-a-study-of-8-years-of-follow-up
#16
RANDOMIZED CONTROLLED TRIAL
Vincenzo Parisi
In this study we assessed, by simultaneous recordings of visual evoked potentials (VEPs) and pattern-electroretinograms (PERGs), the effects cytidine-5'-diphosphocholine (citicoline) on retinal function and/or visual cortical responses in glaucoma patients. Thirty glaucoma patients were randomly divided into two age-matched groups: patients in group GC (15 patients) were treated with citicoline (1,000 mg/die intramuscularly) for 2 months; patients in group GP (15 patients) were treated with placebo for 2 months...
January 2005: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/12640353/oral-citicoline-treatment-improves-visual-pathway-function-in-glaucoma
#17
Robert Rejdak, Jerzy Toczołowski, Jacek Kurkowski, Marek L Kamiński, Konrad Rejdak, Zbigniew Stelmasiak, Paweł Grieb
BACKGROUND: Increased latency and reduced amplitude of visual evoked potentials (VEP), frequently encountered in ocular hypertension or open-angle glaucoma, suggest slowed neural conduction in the visual pathways. An improvement in VEP latency and amplitude has been reported following repeated intramuscular injections of citicoline, a neuroprotective drug. Our aim was to find whether citicoline given orally would produce a similar effect. MATERIAL/METHODS: VEP latency and amplitude were measured in 21 glaucomatous eyes prior to and after two bi-weekly courses of citicoline taken orally in a dose of 1 gram/day...
March 2003: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/12438935/citicoline-has-a-protective-effect-on-damaged-retinal-ganglion-cells-in-mouse-culture-retina
#18
Toshiyuki Oshitari, Naoya Fujimoto, Emiko Adachi-Usami
Some clinical reports indicate that exogenous CDP-choline (citicoline) may have a therapeutic effect in patients with glaucoma. However, the precise effect of citicoline on damaged retinal ganglion cells (RGCs) remains to be explained. We performed tissue culture of mouse retinal explants and investigated the effect of citicoline on damaged RGCs by the quantitative analysis of TdT-dUTP terminal nick-end labeling (TUNEL) staining and the assessment of the number of regenerating neurites. The TUNEL-positive ratio in 0...
November 15, 2002: Neuroreport
https://www.readbyqxmd.com/read/12097797/citicoline-treatment-increases-retinal-dopamine-content-in-rabbits
#19
Robert Rejdak, Jerzy Toczołowski, Janusz Solski, Dariusz Duma, Paweł Grieb
Citicoline (exogenous cytidine-5'-diphosphocholine) was reported to enhance dopaminergic neurotransmission in the brain. A few clinical studies showed beneficial effects of this drug on the function of the visual pathway in patients with glaucoma or amblyopia. The present study was aimed at determining whether citicoline could influence retinal catecholamine levels in adult male Albino rabbits. The animals received the drug (50 mg/kg i.p., twice daily) or vehicle for 7 days, and retinal catecholamine concentrations were determined by HPLC...
May 2002: Ophthalmic Research
https://www.readbyqxmd.com/read/11782957/pharmacodynamics-of-citicoline-relevant-to-the-treatment-of-glaucoma
#20
REVIEW
Pawel Grieb, Robert Rejdak
Citicoline (exogenous CDP-choline) is a nontoxic and well-tolerated drug used in pharmacotherapy of brain insufficiency and some other neurological disorders, such as stroke, brain trauma, and Parkinson's disease. A few reports indicate that citicoline treatment may also be beneficial in glaucoma. Currently glaucoma is considered a neurodegenerative disease in which retinal ganglion cells (RGC) slowly die, likely in the apoptotic mechanism. Endogenous CDP-choline is a natural precursor of cellular synthesis of phospholipids, mainly phosphatydylcholine (PtdCho)...
January 15, 2002: Journal of Neuroscience Research
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