keyword
https://read.qxmd.com/read/38533534/early-access-flow-rate-predicts-vascular-access-patency-related-intervention-in-the-first-year-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Matthias Bergmann, Butros Fakhoury, Tiago Barroso, Scott G Prushik, Bertrand L Jaber, Vaidyanathapuram S Balakrishnan
INTRODUCTION: Arteriovenous fistulas and grafts are lifelines for most hemodialysis patients, and a low access flow rate often requires patency-related intervention, such as angioplasty or thrombectomy, to prevent access failure. We examined whether early access flow rate, measured after initial fistula/graft cannulation, predicts vascular access patency-related intervention within 1 year. METHODS: This was a single-center retrospective cohort study. Among 172 patients undergoing surgical creation of a fistula/graft, 52 (30...
March 27, 2024: Hemodialysis International
https://read.qxmd.com/read/38522954/the-association-between-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-chronic-kidney-disease-in-a-chinese-adult-population-a-cross-sectional-study
#2
JOURNAL ARTICLE
Lingling Xu, Dongling Li, Zongwei Song, Jin Liu, Yang Zhou, Junwei Yang, Ping Wen
BACKGROUND: Monocyte to high-density lipoprotein cholesterol ratio (MHR) was confirmed as a novel inflammatory marker and strongly associated with the risk of several diseases. This study aimed to investigate the relationship between MHR and chronic kidney disease (CKD) in a Chinese adult population. METHODS: In this cross-sectional study, 232,775 community-dwelling adults in Binhai who completed health checkups in 2021 were enrolled. Participants were categorized based on the MHR quartiles...
December 2024: Renal Failure
https://read.qxmd.com/read/38520149/sodium-glucose-cotransporter-2-inhibitors-and-the-risk-of-atrial-fibrillation-in-patients-with-type-2-diabetes-a-population-based-cohort-study
#3
JOURNAL ARTICLE
Talip E Eroglu, Ruben Coronel, Patrick C Souverein
AIMS: Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) have a direct cardiac effect that is likely to be independent of its glucose lowering renal effect. Previous research has shown that SGLT2-is mitigate heart failure and prevent arrhythmic cardiac death. Our objective is to determine whether SGLT-2is reduce atrial fibrillation (AF) in comparison to other second-to third-line antidiabetic drugs in type 2 diabetes. METHODS AND RESULTS: We conducted a population-based, new-user active comparator cohort study using data from the UK Clinical Practice Research Datalink...
March 22, 2024: European Heart Journal. Cardiovascular Pharmacotherapy
https://read.qxmd.com/read/38516874/the-potential-for-improved-outcomes-in-the-prevention-and-therapy-of-diabetic-kidney-disease-through-stacking-of-drugs-from-different-classes
#4
REVIEW
David S H Bell, Terri Jerkins
Aggressive therapy of diabetic kidney disease (DKD) can not only slow the progression of DKD to renal failure but, if utilized at an early enough stage of DKD, can also stabilize and/or reverse the decline in renal function. The currently recognized standard of therapy for DKD is blockade of the renin-angiotensin system with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). However, unless utilized at a very early stage, monotherapy with these drugs in DKD will only prevent or slow the progression of DKD and will neither stabilize nor reverse the progression of DKD to renal decompensation...
March 22, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38516524/growing-concerns-about-using-hypoxia-inducible-factor-prolyl-hydroxylase-inhibitors-for-the-treatment-of-renal-anemia
#5
REVIEW
Takeshi Nakanishi, Takahiro Kuragano
Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have emerged as a novel therapeutic class for treating anemia in patients with chronic kidney disease. Small molecule analogs of α-ketoglutarate (AKG), an essential substrate for 2-oxoglutarate-dependent dioxygenases (2-OGDDs), including prolyl hydroxylase domain proteins (PHDs), inhibit PHDs pharmacologically and thereby prevent HIF degradation. HIF stabilization alleviates anemia through several stimulatory effects on erythropoiesis, but it also affects the expression of many anemia-unrelated genes whose protein products exert important functions in vivo ...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38516430/efficacy-of-angiotensin-receptor-neprilysin-inhibitor-and-its-renal-outcome-in-heart-failure-patients-a-systematic-review-of-randomized-clinical-trials
#6
REVIEW
Naiela E Almansouri, Saloni Bakkannavar, Youmna Faheem, Amisha Jaiswal, Kainaat Shergill, Kusalik Boppana, Tuheen Sankar Nath
Heart failure (HF) is a major cause of morbidity and mortality and imposes a significant financial burden on healthcare systems globally. Angiotensin receptor-neprilysin inhibitor (ARNI), a novel neuroendocrine inhibitor, is frequently used in treating HF. However, there is still limited understanding regarding how it compares to other neuroendocrine inhibitors, such as angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs). The purpose of this research is to present the most recent data regarding the efficacy and renal impact of ARNIs in the treatment of HF in comparison to ACE inhibitors and ARBs...
February 2024: Curēus
https://read.qxmd.com/read/38515271/cardiopulmonary-bypass-associated-acute-kidney-injury-better-understanding-and-better-prevention
#7
REVIEW
Xutao Yang, Li Zhu, Hong Pan, Yi Yang
Cardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range and definition of CPB-associated AKI and discuss the possible impact of different disease recognition methods on research outcomes. Furthermore, we introduce the specialized equipment and procedural intricacies associated with CPB surgeries. Based on recent research, we discuss the potential pathogenesis of AKI that may result from CPB, including compromised perfusion and oxygenation, inflammatory activation, oxidative stress, coagulopathy, hemolysis, and endothelial damage...
December 2024: Renal Failure
https://read.qxmd.com/read/38510762/acute-kidney-injury-in-patients-undergoing-extracorporeal-membrane-oxygenation-a-retrospective-cohort-study
#8
JOURNAL ARTICLE
Aswin Surjit, Bipi Prasannan, Jobin Abraham, Anuroop Balagopal, Vavullipathy Narayanan Unni
AIMS AND BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a mode of extracorporeal therapy to support oxygenation of patients with severe cardiac or respiratory failure. Studies have shown that acute kidney injury (AKI) can worsen the outcome in these patients. This study aims to assess the incidence and outcome of AKI in patients on ECMO support. MATERIALS AND METHODS: This retrospective study included 64 patients who underwent ECMO for more than 24 hours...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38506343/prophylactic-corticosteroids-for-cardiopulmonary-bypass-in-adult-cardiac-surgery
#9
REVIEW
Riccardo Giuseppe Abbasciano, Guido Maria Olivieri, Rachel Chubsey, Francesca Gatta, Nathan Tyson, Keertana Easwarakumar, Daniel P Fudulu, Roberto Marsico, Markus Kofler, Ghazi Elshafie, Florence Lai, Mahmoud Loubani, Simon Kendall, Mustafa Zakkar, Gavin J Murphy
BACKGROUND: Cardiac surgery triggers a strong inflammatory reaction, which carries significant clinical consequences. Corticosteroids have been suggested as a potential perioperative strategy to reduce inflammation and help prevent postoperative complications. However, the safety and effectiveness of perioperative corticosteroid use in adult cardiac surgery is uncertain. This is an update of the 2011 review with 18 studies added. OBJECTIVES: Primary objective: to estimate the effects of prophylactic corticosteroid use in adults undergoing cardiac surgery with cardiopulmonary bypass on the: - co-primary endpoints of mortality, myocardial complications, and pulmonary complications; and - secondary outcomes including atrial fibrillation, infection, organ injury, known complications of steroid therapy, prolonged mechanical ventilation, prolonged postoperative stay, and cost-effectiveness...
March 20, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38504911/post-operative-sepsis-induced-acute-respiratory-distress-syndrome-risk-factors-for-a-life-threatening-complication
#10
JOURNAL ARTICLE
Miguel Bardají-Carrillo, Marta Martín-Fernández, Rocío López-Herrero, Juan Manuel Priede-Vimbela, María Heredia-Rodríguez, Esther Gómez-Sánchez, Estefanía Gómez-Pesquera, Mario Lorenzo-López, Pablo Jorge-Monjas, Rodrigo Poves-Álvarez, Jesús Villar, Eduardo Tamayo
INTRODUCTION: Prevalence and mortality of the acute respiratory distress syndrome (ARDS) in intensive care units (ICU) are unacceptably high. There is scarce literature on post-operative sepsis-induced ARDS despite that sepsis and major surgery are conditions associated with ARDS. We aimed to examine the impact of post-operative sepsis-induced ARDS on 60-day mortality. METHODS: We performed a secondary analysis of a prospective observational study in 454 patients who underwent major surgery admitted into a single ICU...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38501942/natural-intestinal-metabolite-xylitol-reduces-brd4-levels-to-mitigate-renal-fibrosis
#11
JOURNAL ARTICLE
Zhouke Tan, Ze Wang, Qianglin Zeng, Xiaoyou Liu, Yamei Zhang, Shujue Li, Junlin Huang, Yunong Zeng, Zongshun Huang, Can Jin, Ningying Fu, Qian Zhao, Yingsong Mu, Ziyi Wang, Jie Xiao, Hong Yang, Guibao Ke
Renal fibrosis is a typical pathological change from chronic kidney disease (CKD) to end-stage renal failure, which presents significant challenges in prevention and treatment. The progression of renal fibrosis is closely associated with the "gut-kidney axis," therefore, although clinical intervention to modulate the "gut-kidney axis" imbalance associated with renal fibrosis brings hope for its treatment. In this study, we first identified the close relationship between renal fibrosis development and the intestinal microenvironment through fecal microtransplantation and non-absorbable antibiotics experiments...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38490660/multicentre-randomised-double-blind-placebo-controlled-proof-of-concept-study-of-lsalt-peptide-as-prevention-of-acute-respiratory-distress-syndrome-and-acute-kidney-injury-in-patients-infected-with-sars-cov-2-covid-19
#12
JOURNAL ARTICLE
Ranjani Somayaji, David R Luke, Arthur Lau, Rahmet Guner, Ŏ Fehmi Tabak, Mark Hepokoski, Nancy Gardetto, Steven A Conrad, Sunil D Kumar, Kalyan Ghosh, Stephen M Robbins, Donna L Senger, Daisy Sun, Rachel K S Lim, Jonathan Liu, Fatma Eser, Ridvan Karaali, Alain Tremblay, Daniel Muruve
OBJECTIVE: Dipeptidase-1 (DPEP-1) is a recently discovered leucocyte adhesion receptor for neutrophils and monocytes in the lungs and kidneys and serves as a potential therapeutic target to attenuate inflammation in moderate-to-severe COVID-19. We aimed to evaluate the safety and efficacy of the DPEP-1 inhibitor, LSALT peptide, to prevent specific organ dysfunction in patients hospitalised with COVID-19. DESIGN: Phase 2a randomised, placebo-controlled, double-blinded, trial...
March 15, 2024: BMJ Open
https://read.qxmd.com/read/38490067/preeclampsia-epidemiology-ies-and-pathophysiology-ies
#13
REVIEW
James M Roberts
Preeclampsia/eclampsia was first described 2000 years ago. Concepts guiding diagnosis have changed over time making longitudinal studies challenging. Similarly, concepts of pathophysiology have evolved from eclampsia as a pregnancy seizure disorder to preeclampsia as a hypertensive and renal disorder to our current concept of a preeclampsia as a pregnancy specific, multisystemic inflammatory disorder. Although preeclampsia is pregnancy specific and many pathophysiologic findings begin to resolve with delivery, its impact extends beyond pregnancy...
February 22, 2024: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/38482886/tak-242-improves-sepsis-associated-acute-kidney-injury-in-rats-by-inhibiting-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#14
JOURNAL ARTICLE
Yan-Mei Xia, Yu-Qian Guan, Ji-Fang Liang, Wei-Dong Wu
OBJECTIVE: This study was designed to observe the effect of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway activity on sepsis-associated acute kidney injury (SA-AKI), thereby providing new considerations for the prevention and treatment of SA-AKI. METHODS: The rats were divided into Sham, cecal ligation and puncture (CLP), CLP + vehicle, and CLP + TAK-242 groups. Except the Sham group, a model of CLP-induced sepsis was established in other groups...
December 2024: Renal Failure
https://read.qxmd.com/read/38479158/dapagliflozin-prevents-kidney-podocytes-pyroptosis-via-mir-155-5p-ho-1-nlrp3-axis-modulation
#15
JOURNAL ARTICLE
Zhen-Wang Zhang, Ming-Qiu Tang, Wu Liu, Yi Song, Man-Jun Gao, Ping Ni, Dan-Dan Zhang, Qi-Gui Mo, Bao-Qing Zhao
Diabetic nephropathy (DN) is a significant clinical microvascular complication associated with diabetes mellitus (DM), and end-stage diabetes giving rise to kidney failure is developing into the major etiological factor of chronic kidney failure. Dapagliflozin is reported to limit podocyte damage in DM, which has proven to protect against renal failure. Mounting evidence has demonstrated that pyroptosis is associated with DM progression. Nevertheless, whether pyroptosis causes DN and the underlying molecular pathways remain obscure...
March 12, 2024: International Immunopharmacology
https://read.qxmd.com/read/38477777/risk-factors-for-hip-and-vertebral-fractures-in-chronic-kidney-disease-the-cric-study
#16
JOURNAL ARTICLE
Simon Hsu, Nisha Bansal, Michelle Denburg, Charles Ginsberg, Andrew N Hoofnagle, Tamara Isakova, Joachim H Ix, Cassianne Robinson-Cohen, Myles Wolf, Bryan R Kestenbaum, Ian H de Boer, Leila R Zelnick
Fracture risk is high in chronic kidney disease (CKD) and underlying pathophysiology and risk factors may differ from the general population. In a cohort study of 3939 participants in the Chronic Renal Insufficiency Cohort (CRIC), we used Cox regression to test associations of putative risk factors with the composite of first hip or vertebral fracture assessed using hospital discharge codes. Mean age was 58 years, 45% were female, 42% were Black, and 13% were Hispanic. There were 82 hip and 24 vertebral fractures over a mean (SD) 11...
February 4, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38473750/impact-of-immunopathy-and-coagulopathy-on-multi-organ-failure-and-mortality-in-a-lethal-porcine-model-of-controlled-and-uncontrolled-hemorrhage
#17
JOURNAL ARTICLE
Milomir O Simovic, James Bynum, Bin Liu, Jurandir J Dalle Lucca, Yansong Li
Uncontrolled hemorrhage is a major preventable cause of death in patients with trauma. However, the majority of large animal models of hemorrhage have utilized controlled hemorrhage rather than uncontrolled hemorrhage to investigate the impact of immunopathy and coagulopathy on multi-organ failure (MOF) and mortality. This study evaluates these alterations in a severe porcine controlled and uncontrolled hemorrhagic shock (HS) model. Anesthetized female swine underwent controlled hemorrhage and uncontrolled hemorrhage by partial splenic resection followed with or without lactated Ringer solution (LR) or Voluven® resuscitation...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471834/temporal-trends-in-the-initiation-of-dialysis-among-patients-with-heart-failure-with-or-without-diabetes-a-nationwide-study-from-2002-to-2016
#18
JOURNAL ARTICLE
Pauline Knigge, Sørine Lundberg, Jarl E Strange, Mariam E Malik, Nina Nouhravesh, Andrea K Wagner, Gunnar Gislason, Emil L Fosbøl, Nicholas Carlson, Deewa Zahir, Charlotte Andersson, Jawad H Butt, Pardeep Jhund, Mark C Petrie, John J V McMurray, Lars Køber, Morten Schou
BACKGROUND: The incidence and distribution of acute and chronic dialysis among patients with heart failure (HF), stratified by diabetes, remain uncertain. We hypothesized that with improved survival and rising comorbidities, the demand for dialysis would increase over time. METHODS AND RESULTS: Patients with incident HF, aged 18 to 100 years, between 2002 and 2016, were identified using Danish nationwide registers. Primary outcomes included acute and chronic dialysis initiation, HF-related hospitalization, and all-cause mortality...
March 12, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38468229/socioeconomic-inequalities-in-avoidable-mortality-in-italy-results-from-a-nationwide-longitudinal-cohort
#19
JOURNAL ARTICLE
Alessio Petrelli, Martina Ventura, Anteo Di Napoli, Marilena Pappagallo, Silvia Simeoni, Luisa Frova
BACKGROUND: Disparities in avoidable mortality have never been evaluated in Italy at the national level. The present study aimed to assess the association between socioeconomic status and avoidable mortality. METHODS: The nationwide closed cohort of the 2011 Census of Population and Housing was followed up for 2012-2019 mortality. Outcomes of preventable and of treatable mortality were separately evaluated among people aged 30-74. Education level (elementary school or less, middle school, high school diploma, university degree or more) and residence macro area (North-West, North-East, Center, South-Islands) were the exposures, for which adjusted mortality rate ratios (MRRs) were calculated through multivariate quasi-Poisson regression models, adjusted for age at death...
March 11, 2024: BMC Public Health
https://read.qxmd.com/read/38465107/factors-influencing-the-choice-of-glucose-lowering-medications-among-physicians-treating-patients-with-type-2-diabetes
#20
JOURNAL ARTICLE
Mohammed E AlSofiani, Danah Z AlHalees, Joud A Aljebreen, Joud A Abu Dahesh, Ghada S Bamogaddam, Ghaida M AlBraithen, Anwar Jammah
Background The factors considered by physicians when prescribing a glucose-lowering agent to patients with type 2 diabetes (T2D) in real-world settings are not necessarily consistent with those recommended by clinical practice guidelines. Here, we identify the major factors that drive physicians' selection of glucose-lowering agents in the real world and how these factors may differ by physician's specialty.  Methods A web-based survey was conducted among 135 physicians who manage patients with T2D in Saudi Arabia...
February 2024: Curēus
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