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mohamed abdallah

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https://www.readbyqxmd.com/read/29338089/outcomes-of-patients-diagnosed-with-carcinoma-metastatic-to-the-neck-from-an-unknown-primary-source-and-treated-with-intensity-modulated-radiation-therapy
#1
Mona Kamal, Abdallah S R Mohamed, Clifton David Fuller, Erich M Sturgis, Faye M Johnson, William H Morrison, G Brandon Gunn, Katherine A Hutcheson, Jack Phan, Stefania Volpe, Sweet Ping Ng, Renata Ferrarotto, Steven J Frank, Heath D Skinner, David I Rosenthal, Adam S Garden
BACKGROUND: There are few published studies to guide the treatment of carcinoma metastatic to the neck from an unknown primary (CUP). In this regard, the objective of the current study was to share the authors' current experience treating patients with CUP using intensity-modulated radiation therapy (IMRT), which principally targeted both sides of the neck, the nasopharynx, and the oropharynx. METHODS: This was a retrospective study in which an institutional database search was conducted to identify patients with CUP who received IMRT...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29336942/malleable-penile-implant-is-an-effective-therapeutic-option-in-men-with-peyronie-s-disease-and-erectile-dysfunction
#2
Mohamad Habous, Alaa Tealab, Mohammed Farag, Tarek Soliman, Ben Williamson, Saad Mahmoud, Amin Elserafy, Zenhom Mekawi, Abdallah Remeah, Mohammed Nassar, Osama Laban, Osama Abdelwahab, Saleh Binsaleh, Simone Giona, David Ralph, John Mulhall
BACKGROUND: The inflatable penile prosthesis (IPP) is typically the preferred implant for Peyronie's disease (PD) and malleable penile prostheses (MPPs) have been discouraged. AIMS: To evaluate the effectiveness and patient satisfaction of the MPP vs IPP in patients with PD. METHODS: Men with PD and erectile dysfunction who elected for penile implant surgery constituted the study population. Preoperatively, demographic and comorbidity parameters were recorded...
January 11, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29335510/tio2-nanoribbons-carbon-nanotubes-composite-with-enhanced-photocatalytic-activity-fabrication-characterization-and-application
#3
Mohamed Shaban, Abdallah M Ashraf, Mostafa R Abukhadra
TiO2 nanoribbons (TiO2 NRs) loaded with FeCo-Al2O3 catalyst were synthesized and used as a precursor in the synthesis of TiO2 nanoribbons/carbon nanotubes (TiO2 NRs/CNTs) composite by a chemical vapor deposition (CVD) method. TiO2 NRs and TiO2 NRs/CNTs composite were characterized by XRD, FT-IR, TEM, SEM, EDX and UV-Vis spectrophotometer. The results revealed the formation of TiO2-B and hydrogen titanate nanoribbon like structures by the hydrothermal treatment. After loading TiO2 NRs by FeCo-Al2O3 catalyst and the CVD growth of carbon nanotubes, the synthetic TiO2 nanoribbons converted entirely to TiO2-B nanoribbons with nanopits structure...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334895/challenges-imposed-by-minor-reference-alleles-on-the-identification-and-reporting-of-clinical-variants-from-exome-data
#4
Mahmoud Koko, Mohammed O E Abdallah, Mutaz Amin, Muntaser Ibrahim
BACKGROUND: The conventional variant calling of pathogenic alleles in exome and genome sequencing requires the presence of the non-pathogenic alleles as genome references. This hinders the correct identification of variants with minor and/or pathogenic reference alleles warranting additional approaches for variant calling. RESULTS: More than 26,000 Exome Aggregation Consortium (ExAC) variants have a minor reference allele including variants with known ClinVar disease alleles...
January 15, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29325696/urinary-mrna-analysis-of-biomarkers-to-epithelial-mesenchymal-transition-of-renal-allograft
#5
Imen Mezni, Pierre Galichon, Mohammed Mongi Bacha, Yi-Chun Xu-Dubois, Imen Sfar, David Buob, Sabrina Benbouzid, Rim Goucha, Yousr Gorgi, Ezzedine Abderrahim, Mondher Ounissi, Karine Dahan, Nacera Ouali, Alexandre Hertig, Isabelle Brocheriou, Aly Raies, Taieb Ben Abdallah, Éric Rondeau
Renal allograft loss is most often a chronic process, irrespective of the mechanism at stake. In this prospective study, we studied the expression of epithelial to mesenchymal transition (EMT) markers vimentin and β-catenin by immunohistochemistry in the surveillance biopsy and measured the mRNA encoding vimentin (VIM), CD45, GAPDH and uroplakin 1a (UPK) by quantitative PCR in urinary cells in 75 renal transplant patients. The aim is to establish a simple screening test for chronic renal allograft dysfunction...
January 8, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29317127/low-dosing-of-gonadotropins-in-in%C3%A2-vitro-fertilization-cycles-for-women-with-poor-ovarian-reserve-systematic-review-and-meta-analysis
#6
Mohamed Abdel-Fattah Youssef, Madelon van Wely, Monique Mochtar, Usama Mohamed Fouda, Ashraf Eldaly, Eman Zein El Abidin, Ahmed Elhalwagy, Ahmed Abdel Mageed Abdallah, Sherif Sameh Zaki, Mohamed Sayed Abdel Ghafar, Mohamed Nagi Mohesen, Fulco van der Veen
OBJECTIVE: To evaluate the effectiveness of low doses of gonadotropins and gonadotropins combined with oral compounds compared with high doses of gonadotropins in ovarian stimulation regimens in terms of ongoing pregnancy per fresh IVF attempt in women with poor ovarian reserve undergoing IVF/intracytoplasmic sperm injection (ICSI) treatment. DESIGN: A systematic review and meta-analysis of randomized controlled studies that evaluate the effectiveness of low dosing of gonadotropins alone or combined with oral compounds compared with high doses of gonadotropins in women with poor ovarian reserve undergoing IVF/ICSI treatment...
January 6, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29316568/effect-of-submerged-vs-nonsubmerged-implant-placement-protocols-on-implant-failure-and-marginal-bone-loss-a-systematic-review-and-meta-analysis
#7
Ramy Moustafa Moustafa Ali, Ahmed Yaseen Alqutaibi, Amr Salah El-Din Gomaa, Mohamed Farouk Abdallah
PURPOSE: To compare prosthesis and implant failures and marginal bone loss (MBL) resulting from submerged vs nonsubmerged dental implant protocols. MATERIALS AND METHODS: Electronic and manual searches of two databases (MEDLINE [PubMed] and Cochrane) were conducted to identify randomized controlled trials (RCTs) comparing submerged to nonsubmerged dental implant protocols. Data were independently extracted by two reviewers, and meta-analyses were performed for the included RCTs...
January 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29302695/barriers-to-combined-modality-therapy-for-limited-stage-small-cell-lung-cancer
#8
Todd A Pezzi, David L Schwartz, Abdallah S R Mohamed, James W Welsh, Ritsuko U Komaki, Stephen M Hahn, Boris Sepesi, Christopher M Pezzi, Clifton D Fuller, Stephen G Chun
Importance: Combined-modality therapy with chemotherapy and radiation therapy plays a crucial role in the upfront treatment of patients with limited-stage small-cell lung cancer (SCLC), but there may be barriers to utilization in the United States. Objective: To estimate utilization rates and factors associated with chemotherapy and radiation therapy delivery for limited-stage SCLC using the National Cancer Database. Design, Setting, and Participants: Analysis of initial management of all limited-stage SCLC cases from 2004 through 2013 in the National Cancer Database...
January 4, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29297179/vascular-endothelial-growth-factor-receptor-inhibition-enhances-copd-picture-in-mice-exposed-to-waterpipe-smoke
#9
Abdallah Alzoubi, Rawan Ghazwi, Karem Alzoubi, Mohammad Alqudah, Khalid Kheirallah, Omar Khabour, Mohammed Allouh
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is marked by destruction of alveolar architecture. Preclinical modeling for COPD is challenging. Chronic cigarette smoke exposure, the reference animal model of COPD, is time-inefficient, while exposure to waterpipe smoke (WPS), a surging smoking modality, was not fully tested for its histopathological pulmonary consequences. Since alveolar damage and pulmonary vascular endothelial dysfunction are integral to COPD pathology, lung histopathological effects of WPS were temporally evaluated, alone or in combination with vascular endothelial growth factor receptor (VEGFR) inhibition in mice...
January 3, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29295662/use-of-beta-subunit-of-human-chorionic-gonadotropin-assay-as-a-diagnostic-tool-for-prelabour-rupture-of-membranes
#10
Ashraf Eldaly, Eman Omran, Mohamed A Youssef, Ahmed Abdallah, Ahmed Metwally, Hisham Haggag, Rasha Elkaffas
PURPOSE: The study aimed at assessment of the accuracy of β-hCG test in vaginal washing fluid for diagnosis of prelabour rupture of membranes (PROM). PATIENTS AND METHODS: Two groups of pregnant women from 17 to 38 weeks of gestation were recruited. The first group (PROM group) included 50 pregnant women with unequivocal PROM. The other group included 50 pregnant women with intact membranes. Sterile speculum examination was performed. If less than 5 cc was collected or no fluid found, 10 cc sterile saline was sprinkled on the vaginal wall and 5 cc were recollected in a sterile syringe...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29288514/high-efficacy-of-ombitasvir-paritaprevir-ritonavir-plus-dasabuvir-in-hepatitis-c-genotypes-4-and-1-infected-patients-with-severe-chronic-kidney-disease
#11
Faisal M Sanai, Abdullah S Alghamdi, Ahmad A Afghani, Khalid Alswat, Adnan AlZanbagi, Mosfer N Alghamdi, Abdallah AlMousa, Mohammed Aseeri, Abdullah M Assiri, Mohamed A Babatin
Limited data has shown high efficacy of co-formulated ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) in the treatment of hepatitis C virus (HCV) genotype (GT)-4, and combined with dasabuvir (DSV) in GT1 patients, with chronic kidney disease (CKD) stage 4-5 (<30 mL/min/1.73 m2 ). We assessed real-world safety and efficacy of OBV/PTV/r ± DSV in GT1 and 4-infected patients. METHODS: In this observational cohort (n=67), we enrolled stage 4-5 CKD treatment-naïve or Peginterferon/RBV-experienced GT4-infected patients (n=32) treated for 12-24 weeks with OBV/PTV/r ± RBV, and plus DSV in GT1 patients (n=35, including 3 with GT1/4 co-infection)...
December 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29288025/thiotagetin-b-and-tagetannins-a-and-b-new-acetylenic-thiophene-and-digalloyl-glucose-derivatives-from-tagetes-minuta-and-evaluation-of-their-in-vitro-antioxidative-and-anti-inflammatory-activity
#12
Sabrin R M Ibrahim, Hossam M Abdallah, Ali M El-Halawany, Ahmed Esmat, Gamal A Mohamed
The three new metabolites: thiotagetin B (2) [(Z)-1″-([2,2'-bithiophen]-5-yl)-8″-chloro-6″,11″-dimethylundeca-6″,10″-dien-2″-yn-9″-one], tagetannin A (9) [3,4-bis-(galloyl-3,5-dimethyl ether)-(α/β)-d-glucopyranose], and tagetannin B (10) [2,3-bis-(galloyl-3,5-dimethyl ether)-(α/β)-d-glucopyranose], along with ecliptal (5-formyl-α-terthiophene) (1), 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene (3), scopoletin (4), p-hydroxybenzoic acid (5), protocatechuic acid methyl ester (6), gallic acid (7), and patuletin 7-O-β-d-glucoside (8) were isolated from the aerial parts of Tagetes minuta L...
December 26, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29234542/demographics-and-sexual-characteristics-of-sex-enhancing-medication-users-study-of-a-web-based-cross-sectional-sample-of-sexually-active-men
#13
Abul-Fotouh Ahmed, Saad Alshahrani, Anthony Morgan, Ahmed H Gabr, Mohamed Abdel-Razik, Abdallah Daoud
Objectives: To evaluate the frequency of sex-enhancing medications (S-EM) use and to investigate the demographics and sexual characteristics of the S-EM users amongst a Saudi Arabian male population. Subjects and methods: A cross-sectional sample of 1176 Saudi Arabian men was recruited using a web-based survey between 1 January and 1 April 2015. The survey included multiple open and closed questions to assess the frequency of S-EM use; and demographics, clinical, and sexual characteristics of S-EM users, as well as their perceptions of S-EM...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29229507/patient-reported-dry-mouth-instrument-comparison-and-model-performance-for-correlation-with-quality-of-life-in-head-and-neck-cancer-survivors
#14
Mona Kamal, David I Rosenthal, Stefania Volpe, Ryan P Goepfert, Adam S Garden, Katherine A Hutcheson, Karine A Al Feghali, Mohamed Ahmed Mohamed Meheissen, Salman A Eraj, Amy E Dursteler, Bowman Williams, Joshua B Smith, Jeremy M Aymard, Joel Berends, Aubrey L White, Steven J Frank, William H Morrison, Richard Cardoso, Mark S Chambers, Erich M Sturgis, Tito R Mendoza, Charles Lu, Abdallah S R Mohamed, Clifton D Fuller, G Brandon Gunn
PURPOSE: To identify a clinically meaningful cut-point for the single item dry mouth question of the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). METHODS: Head and neck cancer survivors who had received radiation therapy (RT) completed the MDASI-HN, the University of Michigan Hospital Xerostomia Questionnaire (XQ), and the health visual analog scale (VAS) of the EuroQol Five Dimension Questionnaire (EQ-5D). The Bayesian information criteria (BIC) were used to test the prediction power of each tool for EQ-5D VAS...
December 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29225690/do-we-need-regional-guidelines-for-breast-cancer-management-in-the-mena-region-mena-breast-cancer-guidelines-project
#15
Reham Fayed, Dina Hamza, Heba Abdallah, Mohamed Kelany, Amira Tahseen, Adel T Aref
Purpose: Breast cancer is the most common cancer among females worldwide in general and in the Middle East and the North African region (MENA region) in particular. Management of breast cancer in the MENA region faces a lot of challenges, which include younger age at presentation, aggressive behaviour, lack of national breast screening programmes and lack of reliable data registries as well as socioeconomic factors. These factors make applying the international guidelines for breast cancer management very challenging...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29202409/a-fluorine-scan-of-a-tubulin-polymerization-inhibitor-isocombretastatin-a-4-design-synthesis-molecular-modelling-and-biological-evaluation
#16
Timothée Naret, Jérôme Bignon, Guillaume Bernadat, Mohamed Benchekroun, Helene Levaique, Christine Lenoir, Joelle Dubois, Alain Pruvost, François Saller, Delphine Borgel, Boris Manoury, Veronique Leblais, Romain Darrigrand, Sébastien Apcher, Jean-Daniel Brion, Etienne Schmitt, Frédéric R Leroux, Mouad Alami, Abdallah Hamze
A novel series of tubulin polymerization inhibitors, based on fluorinated derivatives of isocombretastatin A-4 was synthesized with the goal of evaluating the effect of these compounds on the proliferative activity. The introduction of fluorine atom was performed on the phenyl ring or at the linker between the two aromatic rings. The modification of isoCA-4 by introduction of difluoromethoxy group at the para-position (3i) and substitution of the two protons of the linker by two fluorine atoms (3m), produced the most active compounds in the series, with IC50 values of 0...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29188298/adjuvant-sandwich-chemotherapy-plus-radiotherapy-vs-adjuvant-chemotherapy-alone-for-locally-advanced-bladder-cancer-after-radical-cystectomy-a-randomized-phase-2-trial
#17
Mohamed S Zaghloul, John P Christodouleas, Andrew Smith, Ahmed Abdallah, Hany William, Hussein M Khaled, Wei-Ting Hwang, Brian C Baumann
Importance: Locoregional failure for patients with locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity and mortality. Adjuvant radiotherapy (RT) can decrease locoregional failure but has not been studied in the chemotherapy era. Objective: To investigate if adjuvant sequential RT plus chemotherapy can improve locoregional recurrence-free survival (LRFS) compared with adjuvant chemotherapy alone...
November 29, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29186242/study-of-serum-levels-and-skin-expression-of-s100b-protein-in-psoriasis
#18
Samar Abdallah M Salem, Ekramy Ahmed El-Khateeb, Mervat Harvy, Hanaa Mohamed El-Sayed Emam, Wafaa Abdelaal, Reham El Nemr, Omneya Osama El-Hagry
BACKGROUND: S100B protein was reported to be elevated in psoriatic patients' serum, with no previous evaluation of its skin expression, in contrast to the extensively studied S100 protein. OBJECTIVE: To evaluate the serum level and skin expression of S100B in psoriasis to assess its possible involvement in its pathogenesis. METHODS: Serum level of S100B protein was estimated in 40 psoriatic patients of different clinical varieties and 10 healthy controls...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29169353/correction-to-long-term-patient-reported-outcomes-following-radiation-therapy-for-oropharyngeal-cancer-cross-sectional-assessment-of-a-prospective-symptom-survey-in-patients-%C3%A2-65%C3%A2-years-old
#19
Salman A Eraj, Mona K Jomaa, Crosby D Rock, Abdallah S R Mohamed, Blaine D Smith, Joshua B Smith, Theodora Browne, Luke C Cooksey, Bowman Williams, Brandi Temple, Kathryn E Preston, Jeremy M Aymard, Neil D Gross, Randal S Weber, Amy C Hessel, Renata Ferrarotto, Jack Phan, Erich M Sturgis, Ehab Y Hanna, Steven J Frank, William H Morrison, Ryan P Goepfert, Stephen Y Lai, David I Rosenthal, Tito R Mendoza, Charles S Cleeland, Kate A Hutcheson, Clifton D Fuller, Adam S Garden, G Brandon Gunn
In the original publication [1] the name of author Jeremy M. Aymard was spelled wrong. The original article was updated to rectify this error.
November 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29159878/arsenobetaine-an-ecophysiologically-important-organoarsenical-confers-cytoprotection-against-osmotic-stress-and-growth-temperature-extremes
#20
Tamara Hoffmann, Bianca Warmbold, Sander H J Smits, Britta Tschapek, Stefanie Ronzheimer, Abdallah Bashir, Chiliang Chen, Anne Rolbetzki, Marco Pittelkow, Mohamed Jebbar, Andreas Seubert, Lutz Schmitt, Erhard Bremer
Arsenic, a highly cytotoxic and cancerogenic metalloid, is brought into the biosphere through geochemical sources and anthropogenic activities. A global biogeochemical arsenic biotransformation cycle exists in which inorganic arsenic species are transformed into organoarsenicals, which are subsequently mineralized again into inorganic arsenic compounds. Microorganisms contribute to this biotransformation process greatly and one of the organoarsenicals synthesized and degraded in this cycle is arsenobetaine...
November 21, 2017: Environmental Microbiology
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