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amal makhlouf

Salwa Salah, Ghada E A Awad, Amal I A Makhlouf
Traditional azole antifungal formulations suffer from poor retention in the vaginal cavity, irritation and burning of the vaginal area. In the present work, we aim at the development of a novel miconazole (MCZ) microsponges gel as an attractive dosage form for vaginal candidiasis. The proposed formula has the potential to minimize the local side effects of the drug due to the controlled release characteristic, which increases patient compliance. Moreover, the mucosal retention effect of the microsponges in addition to the bioadhesion property of Carbopol gel prolongs the retention of the dosage form in the vagina and consequently improves the therapeutic efficiency...
March 1, 2018: European Journal of Pharmaceutical Sciences
Amal Ben Amira, Ines Makhlouf, Raul Flaviu Petrut, Frédéric Francis, Julien Bauwens, Hamadi Attia, Souhail Besbes, Christophe Blecker
In the present paper, techno-functional properties of rennet derived from C. cardunculus, prepared at various pH (from 3 to 6), were investigated. It was found that the extract prepared at pH 3 had the best milk-clotting properties (MCA/PA ratio). It presented also the highest enzyme content, determined by densitometry analysis on 1D and 2D gels electrophoresis. Formation of milk gels produced by the extracts and chymosin was monitored using dynamic rheology and turbiscan. It can be assumed that by lowering rennet pH, milk pH decreases, causing a significant increase of curd firmness and both elastic (G') and viscous (G″) moduli...
June 15, 2017: Food Chemistry
Galal M El-Mahrouk, Mona H Aboul-Einien, Amal I Makhlouf
Floating pH-sensitive chitosan hydrogels containing metronidazole were developed for the eradication of Helicobacter pylori from the stomach. Hydrogels were prepared by crosslinking medium or high molecular weight chitosan in lyophilized solutions containing metronidazole using either citrate or tripolyphosphate (TPP) salts at 1% or 2% concentration. A 2(3) factorial design was developed to study the influence of formulation parameters on the physical characteristics of the prepared hydrogels. The interaction between hydrogel components was investigated...
December 2016: AAPS PharmSciTech
Ghada Abdelbary, Amal Makhlouf
This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based tablets with enhanced oral bioavailability. Thin film hydration technique was employed to prepare DXI polymeric micelles using Pluronic® F127 and/or P123 solutions in different ratios (ranging from 1:1 up to 1:10). Prepared micelles were characterized regarding particle size, drug loading and entrapment efficiency. Selected formulae were lyophilized in presence of cryoprotectants and subjected to solid-state characterization as well as scanning and transmission electron microscopy...
September 2014: Pharmaceutical Development and Technology
Muftah H El-Naas, Sulaiman Al-Zuhair, Amal Al-Lobaney, Souzan Makhlouf
Batch electrocoagulation experiments were carried out to evaluate the removal of sulfate and COD from petroleum refinery wastewater using three types of electrodes: aluminum, stainless steel, and iron. The effects of current density, electrode arrangement, electrolysis time, initial pH, and temperature were investigated for two wastewater samples with different concentrations of COD and sulfate. The experimental results indicated that the utilization of aluminum, as anode and cathode, was by far the most efficient arrangement in the reduction of both the contaminants...
October 2009: Journal of Environmental Management
Amal El-Beshlawy, Ilham Youssry, Sonia El-Saidi, Ramzi El Accaoui, Yassmin Mansi, Ali Makhlouf, Ali Taher
Cardiac complications, such as pulmonary hypertension (PHT), are the leading cause of death in beta-thalassemia patients. L-Carnitine, due to its role in fatty acid oxidation, might help control the elevation in pulmonary artery systolic pressure (PASP). The objectives of this study were to assess the prevalence of PHT in beta-thalassemia major patients, identify clinical predictors for its development, and determine the potential effects of L-carnitine. In total, 32 patients with beta-thalassemia major were recruited; 16 age- and sex-matched children constituted the control group...
December 2008: Pediatric Hematology and Oncology
Amal El-Beshlawy, Lamis Ragab, Alia Abdel Fattah, Ilham Youssry Ibrahim, Mona Hamdy, Ali Makhlouf, Elie Aoun, Victor Hoffbrand, Ali Taher
INTRODUCTION: Heart disease secondary to chronic anemia and hemosiderosis remains the major cause of morbidity and mortality in thalassemic patients. Chronic anemia and the tissue hypoxia it induces impair free fatty acid oxidation and ATP production in myocardial cells. The use of L-carnitine, a butyric acid derivative, may help overcome some of these defects. OBJECTIVE: To investigate the effect of L-carnitine therapy on cardiac function in thalassemia major patients...
2004: Acta Haematologica
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