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Suzanne M Cadarette, Joann K Ban, Giulia P Consiglio, Cody D Black, Mina Tadrous, Alexandra Marin, David Dubins
OBJECTIVE: To characterize the diffusion of methodological innovation. STUDY DESIGN AND SETTING: Comparative case study analysis of the diffusion of two methods that summarize confounder information into a single score: disease risk score (DRS), and high-dimensional propensity score (hdPS). We completed systematic searches to identify DRS and hdPS papers in the field of pharmacoepidemiology through to the end of 2013, plotted the number of papers and unique authors over time, and created sociograms and animations to visualize co-authorship networks...
December 22, 2016: Journal of Clinical Epidemiology
Tara Gomes, Diana Martins, Mina Tadrous, J Michael Paterson, Baiju R Shah, Jack V Tu, David N Juurlink, Anna Chu, Muhammad M Mamdani
Importance: Given their high costs, payers have considered implementing quantity limits for reimbursement of blood glucose test strips. The effect of these limits on patient outcomes is unknown. Objective: To determine whether the introduction of quantity limits for blood glucose test strips in August 2013 was associated with changes in clinical outcomes. Design, Setting, and Participants: Cross-sectional time series analysis from April 2008 to March 2015 of residents of Ontario, Canada, aged 19 years and older with diabetes who were eligible for public drug coverage...
January 1, 2017: JAMA Internal Medicine
Mina Tadrous, Diana Martins, Zhan Yao, Muhammad M Mamdani, David N Juurlink, Tara Gomes, Tony Antoniou
BACKGROUND: Smoking remains a serious public health concern. Pharmacotherapy for smoking cessation, including bupropion and varenicline, are proven means to increase quit rates. Post-marketing reports describing suicidal behaviours have raised concerns about the safety of varenicline. However, whether varenicline imparts a higher risk of suicide relative to bupropion remains uncertain. METHODS: A population-based nested case-control study in Ontario, Canada, from April 1, 2011 to March 31, 2015 was conducted...
2016: PloS One
Diana Martins, Zhan Yao, Mina Tadrous, Baiju R Shah, David N Juurlink, Muhammad M Mamdani, Tara Gomes
PURPOSE: To examine the concordance between testosterone replacement therapy (TRT) use and established reimbursement criteria, as well as compare the persistence of use among available formulations (injectable, oral, topical gel, transdermal patch) among elderly men in Ontario, Canada. METHODS: We conducted a retrospective cohort study of men aged 66 years or older in Ontario newly treated with testosterone between 1 January 2009 and 31 December 2012 using linked health administrative data...
August 16, 2016: Pharmacoepidemiology and Drug Safety
Gavin Mast, Kimberly Fernandes, Mina Tadrous, Diana Martins, Nathan Herrmann, Tara Gomes
BACKGROUND: Antipsychotics are commonly used to manage behavioral and psychological symptoms of dementia. Concerns over their safety and efficacy in this role have resulted in antipsychotics typically being recommended for short-term usage only when used among dementia patients. However, there is little work examining the duration of antipsychotic treatment in the elderly dementia patient population. OBJECTIVE: To determine the persistence of use of antipsychotics in elderly dementia patients and the role of dose on therapy duration...
June 2016: Drugs—Real World Outcomes
Nikita Arora, Sandra Knowles, Tara Gomes, Muhammad M Mamdani, David N Juurlink, Corine Carlisle, Mina Tadrous
OBJECTIVE: Although antidepressants and antipsychotics are valuable medications in the treatment of select psychiatric disorders, there is increasing focus on the balance of risks and benefits of these drugs as prescribed, particularly in the pediatric population. We examined recent national trends and interprovincial variation in dispensing of antipsychotic and antidepressant prescriptions to the Canadian pediatric population. METHOD: We conducted a population-based cross-sectional study of antidepressant and antipsychotic prescriptions dispensed by Canadian pharmacies to the pediatric population (≤18 years) between 2010 and 2013...
May 12, 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Tara Gomes, Diana Martins, Mina Tadrous, J Michael Paterson, Baiju R Shah, David N Juurlink, Samantha Singh, Muhammad M Mamdani
OBJECTIVES: To evaluate the impact of new quantity limits for blood glucose test strips (BGTS) in August 2013 on utilization patterns and costs in the elderly population of Ontario, Canada. METHODS: We conducted a population-based, cross-sectional time series analysis of all individuals 65 years of age and older who received publically funded BGTSs between August 1, 2010, and July 31, 2015, in Ontario, Canada. The number of BGTSs dispensed and the associated costs were measured for 4 diabetes therapy subgroups-insulin, hypoglycemia-inducing oral agents, non-hypoglycemia-inducing oral agents, and no drug therapy-each month during the study period...
October 2016: Canadian Journal of Diabetes
Laura Desveaux, Tara Gomes, Mina Tadrous, Lianne Jeffs, Monica Taljaard, Jess Rogers, Chaim M Bell, Noah M Ivers
BACKGROUND: Antipsychotic medications are routinely prescribed in nursing homes to address the behavioral and psychological symptoms of dementia. Unfortunately, inappropriate prescribing of antipsychotic medications is common and associated with increased morbidity, adverse drug events, and hospitalizations. Multifaceted interventions can achieve a 12-20 % reduction in antipsychotic prescribing levels in nursing homes. Effective interventions have featured educational outreach and ongoing performance feedback...
March 29, 2016: Implementation Science: IS
Mina Tadrous, Diana Martins, Kathy Lee, Sandra Knowles, Muhammad M Mamdani, David N Juurlink, Tara Gomes
INTRODUCTION: Provincial drug-program policies for the reimbursement of testosterone replacement therapy (TRT) vary across Canada, which may result in marked regional variability in use. METHODS: We conducted a population-based cross-sectional analysis of provincially funded TRT spending and utilization in eight provinces across Canada in 2012. We reported the annual cost per user, total cost, and rate of use of TRT overall and by formulation. RESULTS: We identified 23,544 provincially-funded recipients of TRT in 2012 in the eight provinces studied...
December 2016: Expert Review of Pharmacoeconomics & Outcomes Research
Lindsay Wong, Andrea M Burden, Yan Yun Liu, Mina Tadrous, Nedzad Pojskic, Lisa Dolovich, Andrew Calzavara, Suzanne M Cadarette
BACKGROUND: Smoking is a significant public health concern. The Ontario Pharmacy Smoking Cessation Program was launched in September 2011 to leverage community pharmacists and expand access to smoking cessation services for public drug plan beneficiaries. METHODS: We examined health care utilization data in Ontario to describe public drug plan beneficiaries receiving, and pharmacies providing, smoking cessation services between September 2011 and September 2013...
January 2015: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
Mina Tadrous, Muhammad M Mamdani, David N Juurlink, Murray D Krahn, Linda E Lévesque, Suzanne M Cadarette
AIM: To examine the performance of the disease risk score (DRS) in a cohort study with evidence of policy-induced selection bias. METHODS: We examined two cohorts of new users of bisphosphonates. Estimates for 1-year hip fracture rates between agents using DRS, exposure propensity scores and traditional multivariable analysis were compared. RESULTS: The results for the cohort with no evidence of policy-induced selection bias showed little variation across analyses (-4...
November 2015: Journal of Comparative Effectiveness Research
Lisa-Ann Fraser, Jordan M Albaum, Mina Tadrous, Andrea M Burden, Salimah Z Shariff, Suzanne M Cadarette
BACKGROUND: Bisphosphonates are the first-line therapy for the treatment of osteoporosis. In the province of Ontario, the Ontario Drug Benefit Program funds medications for patients aged 65 years and older. The Ontario Drug Benefit Program has a generic substitution policy that requires lower-cost generic drugs to be dispensed when they are available. However, there is controversy surrounding the efficacy and tolerability of generic bisphosphonates. The objective of this study was to describe patterns in the use of brand-name versus generic formulations when dispensing oral bisphosphonate over a 13-year period...
January 2015: CMAJ Open
John Greiss, Mina Tadrous
No abstract text is available yet for this article.
September 2014: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
Suzanne M Cadarette, Linda Lévesque, Muhammad Mamdani, Sylvie Perreault, David N Juurlink, J Michael Paterson, Greg Carney, Nadia Gunraj, Gillian A Hawker, Mina Tadrous, Lindsay Wong, Colin R Dormuth
BACKGROUND: Orally administered bisphosphonate drugs (i.e., alendronate, etidronate, risedronate) can reduce the risk of vertebral fracture. However, only alendronate and risedronate have proven efficacy in reducing the risk of hip fracture. We sought to examine the comparative effectiveness of orally administered bisphosphonate drugs in reducing hip fractures among older adults. METHODS: We identified new users of orally administered bisphosphonate drugs in British Columbia and Ontario between 2001 and 2008...
September 2013: CMAJ Open
Andrea M Burden, Anjie Huang, Mina Tadrous, Suzanne M Cadarette
UNLABELLED: We examined pharmacy claims for osteoporosis medications dispensed in the community (78 %) and long-term care (LTC) to determine if days supply values matched expected dosing intervals. Results identify potential reporting errors that can have implications for drug exposure misclassification, particularly in LTC where only 59 % of reported values matched expected values. INTRODUCTION: The days supply field is commonly used to examine patterns of drug utilization and classify drug exposure, yet its accuracy has received little attention...
2013: Archives of Osteoporosis
Pierre Rofail, Mariam Tadros, Riham Ywakim, Mina Tadrous, Allison Krug, Leon E Cosler
For oncology patients, febrile neutropenia (FN) can be a serious and costly toxicity of chemotherapy, often forcing a reduction in chemotherapy dose intensity and/or duration. Several therapeutic agents are used to reduce the occurrence of neutropenic episodes: granulocyte colony-stimulating factors (G-CSFs) and granulocyte-macrophage colony-stimulating factors. Appropriate administration of colony-stimulating factors reduces the risk of FN episodes and the costs associated with FN treatment. In the USA, the two most commonly used G-CSFs are filgrastim and the longer-acting pegfilgrastim...
December 2012: Expert Review of Pharmacoeconomics & Outcomes Research
Mina Tadrous, Joshua J Gagne, Til Stürmer, Suzanne M Cadarette
PURPOSE: To systematically examine trends and applications of the disease risk score (DRS) as a confounder summary method. METHODS: We completed a systematic search of MEDLINE and Web of Science® to identify all English language articles that applied DRS methods. We tabulated the number of publications by year and type (empirical application, methodological contribution, or review paper) and summarized methods used in empirical applications overall and by publication year (<2000, ≥2000)...
February 2013: Pharmacoepidemiology and Drug Safety
Anne M Hurley, Mina Tadrous, Elizabeth S Miller
Although epidemiologic evidence has not supported the hypothesis of a causal relationship between thimerosal-containing vaccines and autism, concerns continue about pediatric exposure to mercury through vaccine administration. A statement issued by the American Academy of Pediatrics and the US Public Health Service in 1999 prompted the removal of thimerosal from many vaccines. In 2004, the Immunization Safety Review Committee of the Institute of Medicine rejected the hypothesis of a causal relationship between thimerosal-containing vaccines and autism...
July 2010: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Daniel Gharbawy, Mina Tadrous, Katie Suda
BACKGROUND: Depressive disorders affect approximately 18.8 million patients annually. Influenza, a preventable infectious disease, leads to 50 million new cases each year and up to 40,000 deaths annually. It is believed that depressive symptoms somatize and can lead to decreased immune function. This hypothesis has little or no in vivo evidence. The purpose of this study was to investigate evidence in the literature of a correlation between depression and infection with influenza. METHODOLOGY: The databases PsycINFO, MEDLINE, IPA, and EMBASE were searched with search terms and keywords for "influenza" and "depression" or any derivation...
April 2012: Journal of Affective Disorders
Patrick D Meek, Samuel D Evang, Mina Tadrous, Dianne Roux-Lirange, Darren M Triller, Bora Gumustop
BACKGROUND: Anticholinergic drugs are commonly prescribed for symptomatic treatment of overactive bladder (OAB). While recent meta-analyses have characterized the prevalence of dry mouth among patients utilizing OAB medications, prevalence of constipation has not been systematically reviewed. AIMS: To provide an effect measure for constipation associated with anticholinergic OAB drugs versus placebo. METHODS: A meta-analysis of trials with darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine, and trospium was conducted...
January 2011: Digestive Diseases and Sciences
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