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https://www.readbyqxmd.com/read/29065790/surgical-and-endovascular-venous-arterialization-for-treatment-of-critical-limb-ischaemia
#1
Michael Lichtenberg, Michiel A Schreve, Roberto Ferraresi, Daniel A F van den Heuvel, Çagdas Ünlü, Vincent Cabane, Steven Kum
Patients with critical limb ischaemia have a poor life expectancy. Aggressive revascularization is accepted in order to preserve their independence in the final phase of their lives. Bypass surgery and more recently endovascular interventions with angioplasty and stenting have become the treatment of choice to prevent amputation and to resolve pain. However, as many as 20 % of patients with critical limb ischaemia are unsuitable candidates for a vascular intervention because of extensive occlusions of outflow in the crural and pedal vessels...
October 25, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28965039/insights-into-adhesion-of-abalone-a-mechanical-approach
#2
Jing Li, Yun Zhang, Sai Liu, Jianlin Liu
Many living creatures possess extremely strong capability of adhesion, which has aroused great attention of many scientists and engineers. Based on the self-developed equipment, we measured the normal and shear adhesion strength of the abalone underwater and out of water on different contact surfaces. It is found that the adhesion force of the abalone can amount to 200 or 300 times its body weight. The effects of wettability and roughness of the surface, and the frictional coefficient of mucus on the adhesion strength have been discussed...
September 22, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28912726/cardiovascular-and-muscular-consequences-of-work-matched-interval-type-of-concentric-and-eccentric-pedaling-exercise-on-a-soft-robot
#3
Martin Flück, Rebekka Bosshard, Max Lungarella
Eccentric types of endurance exercise are an acknowledged alternative to conventional concentric types of exercise rehabilitation for the cardiac patient, because they reduce cardiorespiratory strain due to a lower metabolic cost of producing an equivalent mechanical output. The former contention has not been tested in a power- and work-matched situation of interval-type exercise under identical conditions because concentric and eccentric types of exercise pose specific demands on the exercise machinery, which are not fulfilled in current practice...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28900401/development-and-testing-of-a-novel-arm-cranking-powered-watercraft
#4
Thomas Fuglsang, Johnny Padulo, Massimo Spoladore, Michele Dalla Piazza, Luca P Ardigò
There is a lack of human-powered watercrafts for people with lower-body disabilities. The purpose of this study was therefore to develop a watercraft for disabled people and investigate the metabolic cost and efficiency when pedaling. The watercraft was designed by combining parts of a waterbike and a handbike. Nine able-bodied subjects pedaled the watercraft at different speeds on a lake to provide steady-state metabolic measurements, and a deceleration test was performed to measure the hydrodynamic resistance of the watercraft...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28828204/imaging-gait-analysis-an-fmri-dual-task-study
#5
Céline N Bürki, Stephanie A Bridenbaugh, Julia Reinhardt, Christoph Stippich, Reto W Kressig, Maria Blatow
INTRODUCTION: In geriatric clinical diagnostics, gait analysis with cognitive-motor dual tasking is used to predict fall risk and cognitive decline. To date, the neural correlates of cognitive-motor dual tasking processes are not fully understood. To investigate these underlying neural mechanisms, we designed an fMRI paradigm to reproduce the gait analysis. METHODS: We tested the fMRI paradigm's feasibility in a substudy with fifteen young adults and assessed 31 healthy older adults in the main study...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28813906/the-ewrist-a-wearable-wrist-exoskeleton-with-semg-based-force-control-for-stroke-rehabilitation
#6
Charles Lambelet, Mingxing Lyu, Daniel Woolley, Roger Gassert, Nicole Wenderoth
Chronic wrist impairment is frequent following stroke and negatively impacts everyday life. Rehabilitation of the dysfunctional limb is possible but requires extensive training and motivation. Wearable training devices might offer new opportunities for rehabilitation. However, few devices are available to train wrist extension even though this movement is highly relevant for many upper limb activities of daily living. As a proof of concept, we developed the eWrist, a wearable one degree-of-freedom powered exoskeleton which supports wrist extension training...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28776487/physiological-and-biomechanical-responses-between-seated-and-standing-positions-during-distance%C3%A2-based-uphill-time-trials-in-elite-cyclists
#7
Anthony Bouillod, Frederic Grappe
Cyclists regularly change from a seated to a standing position when the gradient increases during uphill cycling. The aim of this study was to analyse the physiological and biomechanical responses between seated and standing positions during distance-based uphill time trials in elite cyclists. Thirteen elite cyclists completed two testing sessions that included an incremental-specific cycling test on a cycle ergometer to determine VO2max and three distance-based uphill time trials in the field to determine physiological and biomechanical variables...
August 4, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28744909/high-diversity-in-neuropeptide-immunoreactivity-patterns-among-three-closely-related-species-of-dinophilidae-annelida
#8
Alexandra Kerbl, Markus Conzelmann, Gáspár Jékely, Katrine Worsaae
Neuropeptides are conserved metazoan signaling molecules, and represent useful markers for comparative investigations on the morphology and function of the nervous system. However, little is known about the variation of neuropeptide expression patterns across closely related species in invertebrate groups other than insects. In this study, we compare the immunoreactivity patterns of 14 neuropeptides in three closely related microscopic dinophilid annelids (Dinophilus gyrociliatus, D. taeniatus and Trilobodrilus axi)...
July 26, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28690745/closed-reduction-of-a-traumatic-hip-dislocation-in-children-case-report
#9
Achraf El Bakkaly, Fouad Ettayebi, Houda Oubeja, Mounir Erraji, Hicham Zerhouni
Traumatic dislocation of the hip in children is a rare disease. It only represents 5% of hip dislocations in all age groups. Before 10 years, the mechanism is often a minimal domestic accident; after 10 years, the dislocation occurs with the waning of an accident of the public highway. It is different from that of the adult by its rarity, its ease of reduction and better prognosis. This is an emergency trauma: risk necrosis of the femoral head (If delayed reduction). We report a rare case of a 3 year old boy, who suffered from bipolar trauma after a fall near his height of his house causing him a detachment of the right humerus and post-traumatic dislocation of the left hip...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28654852/adductor-canal-compression-syndrome-in-an-18-year-old-female-patient-leading-to-acute-critical-limb-ischemia-a-case-report
#10
Yi Zhou, Evan J Ryer, Robert P Garvin, Jeremy L Irvan, James R Elmore
BACKGROUND: Adductor canal compression syndrome is a rare non-atherosclerotic cause of arterial occlusion and limb ischemia. PRESENTATION OF CASE: The patient is an 18-year-old healthy female who presented to the emergency department with acute left lower extremity ischemia. Her symptoms began as sudden onset mild foot pain approximately two months ago. Over the 72h prior to presentation, she developed severe pain, pallor, paralysis, loss of pedal pulses, paresthesia, and poikilothermia...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28515841/demands-of-simulated-commuting-using-an-electrically-assisted-bicycle
#11
D Taylor LA Salle, Robert Shute, Matthew Heesch, Dustin Slivka
The American College of Sports Medicine (ACSM) recommends adults participate in weekly aerobic activity for a minimum of 30 minutes moderate intensity exercise 5 days per week or 20 minutes of vigorous activity 3 days per week. The electrically assisted bicycle may help individuals achieve the ACSM's aerobic recommendations and introduce inactive individuals to physical activity. To compare the physiological requirements of riding a bicycle with electric pedal assist versus non-assist among healthy active young adults...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28484857/muscle-architectural-properties-in-the-common-marmoset-callithrix-jacchus
#12
Naomichi Ogihara, Motoharu Oishi, Ryogo Kanai, Hikaru Shimada, Takahiro Kondo, Kimika Yoshino-Saito, Junichi Ushiba, Hideyuki Okano
The common marmoset, Callithrix jacchus, is a small New World monkey that has recently gained attention as an important experimental animal model in the field of neuroscience as well in rehabilitative and regenerative medicine. This attention reflects the closer phylogenetic relationship between humans and common marmosets compared to that between humans and other experimental animals. When studying the neuronal mechanism behind various types of neurological motor disorders using the common marmoset, possible differences in muscle parameters (e...
July 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28426228/ultrafast-dynamics-of-a-triazene-excited-state-pathways-and-the-impact-of-binding-to-the-minor-groove-of-dna-and-further-biomolecular-systems
#13
Lena Grimmelsmann, Alireza Marefat Khah, Christian Spies, Christof Hättig, Patrick Nuernberger
Many synthetic DNA minor groove binders exhibit a strong increase in fluorescence when bound to DNA. The pharmaceutical-relevant berenil (diminazene aceturate) is an exception with an extremely low fluorescence quantum yield (on the order of 10(-4)). We investigate the ultrafast excited-state dynamics of this triazene by femtosecond time-resolved fluorescence experiments in water, ethylene glycol, and buffer and bound to the enzyme β-trypsin, the minor groove of AT-rich DNA, and G-quadruplex DNA. Ab initio calculations provide additional mechanistic insight...
May 4, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28389987/-hiker-s-feet-a-novel-cutaneous-finding-in-the-inflammatory-myopathies
#14
REVIEW
Jacob T Cox, David M Gullotti, Christopher A Mecoli, Arash H Lahouti, Jemima Albayda, Julie Paik, Cheilonda Johnson, Sonye K Danoff, Andrew L Mammen, Lisa Christopher-Stine
Mechanic's hands is a well-characterized manifestation of select idiopathic inflammatory myopathy (IIM) syndromes. Less well characterized is the hyperkeratosis of the toes and plantar surface of the feet that can also accompany these disorders. We aim to describe common pedal signs in the context of IIM, and suggest that it may be another key feature in the presentation of these syndromes. A cohort of 2145 myositis patient charts gathered since 2003 were retrospectively reviewed using the key search terms "mechanic's feet" and/or "mechanic's foot...
July 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28368959/the-effects-of-a-cycling-warm-up-including-high-intensity-heavy-resistance-conditioning-contractions-on-subsequent-4-km-time-trial-performance
#15
Alan Chorley, Kevin L Lamb
Prior exercise has been shown to improve subsequent performance via different mechanisms. Sport-specific conditioning contractions can be used to exploit the 'post-activation potentiation' (PAP) phenomenon to enhance performance although this has rarely been investigated in short endurance events. The aim of this study was to compare a cycling warm-up with PAP-inducing conditioning contractions (CW) with a moderate intensity warm-up (MW) on performance and physiological outcomes of 4 km time trial. Ten well-trained male endurance cyclists (V[Combining Dot Above]O2max 65...
March 25, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28317554/chimpanzee-and-human-midfoot-motion-during-bipedal-walking-and-the-evolution-of-the-longitudinal-arch-of-the-foot
#16
Nicholas B Holowka, Matthew C O'Neill, Nathan E Thompson, Brigitte Demes
The longitudinal arch of the human foot is commonly thought to reduce midfoot joint motion to convert the foot into a rigid lever during push off in bipedal walking. In contrast, African apes have been observed to exhibit midfoot dorsiflexion following heel lift during terrestrial locomotion, presumably due to their possession of highly mobile midfoot joints. This assumed dichotomy between human and African ape midfoot mobility has recently been questioned based on indirect assessments of in vivo midfoot motion, such as plantar pressure and cadaver studies; however, direct quantitative analyses of African ape midfoot kinematics during locomotion remain scarce...
March 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28263926/dopamine-depletion-impairs-gait-automaticity-by-altering-cortico-striatal-and-cerebellar-processing-in-parkinson-s-disease
#17
Moran Gilat, Peter T Bell, Kaylena A Ehgoetz Martens, Matthew J Georgiades, Julie M Hall, Courtney C Walton, Simon J G Lewis, James M Shine
Impairments in motor automaticity cause patients with Parkinson's disease to rely on attentional resources during gait, resulting in greater motor variability and a higher risk of falls. Although dopaminergic circuitry is known to play an important role in motor automaticity, little evidence exists on the neural mechanisms underlying the breakdown of locomotor automaticity in Parkinson's disease. This impedes clinical management and is in great part due to mobility restrictions that accompany the neuroimaging of gait...
March 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28196415/hierarchical-assembly-of-tough-bioelastomeric-egg-capsules-is-mediated-by-a-bundling-protein
#18
Jun Jie Loke, Akshita Kumar, Shawn Hoon, Chandra Verma, Ali Miserez
Marine snail egg capsules are shock-absorbing bioelastomers made from precursor "egg case proteins" (ECPs) that initially lack long-range order. During capsule formation, these proteins self-assemble into coiled-coil filaments that subsequently align into microscopic layers, a multiscale process which is crucial to the capsules' shock-absorbing properties. In this study, we show that the self-assembly of ECPs into their functional capsule material is mediated by a bundling protein that facilitates the aggregation of coiled-coil building blocks and their gelation into a prefinal capsule prior to final stabilization...
March 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28155264/surgical-and-endovascular-venous-arterialization-ready-to-take-the-desert-by-storm
#19
REVIEW
Michiel A Schreve, Çağdaş Ünlü, Steven Kum, Yih K Tan
Patients with critical limb ischemia have a poor life expectancy, and aggressive revascularization is accepted to maintain their independence in the end stage of life. Bypass surgery and, more recently, endovascular interventions with angioplasty and stenting have become the treatment of choice to prevent amputation and resolve rest pain. Up to 20% of patients with critical limb ischemia are not suitable candidates for a vascular intervention because of extensive occlusions of the outflow in the crural and pedal vessels...
June 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28077872/structural-basis-for-nutrient-acquisition-by-dominant-members-of-the-human-gut-microbiota
#20
Amy J Glenwright, Karunakar R Pothula, Satya P Bhamidimarri, Dror S Chorev, Arnaud Baslé, Susan J Firbank, Hongjun Zheng, Carol V Robinson, Mathias Winterhalter, Ulrich Kleinekathöfer, David N Bolam, Bert van den Berg
The human large intestine is populated by a high density of microorganisms, collectively termed the colonic microbiota, which has an important role in human health and nutrition. The survival of microbiota members from the dominant Gram-negative phylum Bacteroidetes depends on their ability to degrade dietary glycans that cannot be metabolized by the host. The genes encoding proteins involved in the degradation of specific glycans are organized into co-regulated polysaccharide utilization loci, with the archetypal locus sus (for starch utilisation system) encoding seven proteins, SusA-SusG...
January 19, 2017: Nature
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