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https://www.readbyqxmd.com/read/27138036/terbinafine-hydrochloride-trans-ungual-delivery-via-nanovesicular-systems-in-vitro-characterization-and-ex-vivo-evaluation
#1
Noha Ibrahim Elsherif, Rehab Nabil Shamma, Ghada Abdelbary
Treating a nail infection like onychomycosis is challenging as the human nail plate acts as a formidable barrier against all drug permeation. Available oral and topical treatments have several setbacks. Terbinafine hydrochloride (TBH), belonging to the allylamine class, is mainly used for treatment of onychomycosis. This study aims to formulate TBH in a nanobased spanlastic vesicular carrier that enables and enhances the drug delivery through the nail. The nanovesicles were formulated by ethanol injection method, using either SpanĀ® 60 or SpanĀ® 65, together with Tween 80 or sodium deoxycholate as an edge activator...
May 2, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27128792/trans-nasal-zolmitriptan-novasomes-in-vitro-preparation-optimization-and-in-vivo-evaluation-of-brain-targeting-efficiency
#2
Radwa M A Abd-Elal, Rehab N Shamma, Hassan M Rashed, Ehab R Bendas
Migraine attack is a troublesome physiological condition associated with throbbing, intense headache, in one half of the head. Zolmitriptan is a potent second-generation triptan, prescribed for patients with migraine attacks, with or without an aura, and cluster headaches. The absolute bioavailability of zolmitriptan is about 40% for oral administration; due to hepatic first metabolism. Nasal administration would circumvent the pre-systemic metabolism thus increasing the bioavailability of zolmitriptan. In addition, due to the presence of microvilli and high vasculature, the absorption is expected to be faster compared to oral route...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27063851/novel-instantly-soluble-transmucosal-matrix-istm-using-dual-mechanism-solubilizer-for-sublingual-and-nasal-delivery-of-dapoxetine-hydrochloride-in-vitro-in-vivo-evaluation
#3
Shahinaze A Fouad, Rehab N Shamma, Emad B Basalious, Mohamed A El-Nabarawi, Saadia A Tayel
Dapoxetine (D) suffers from poor oral bioavailability (42%) due to extensive first pass metabolism. The usefulness of transmucosal (sublingual and intranasal) drug delivery to improve bioavailability of D, a weak basic drug, has been hampered by its poor solubility in the neutral pH of the body fluids. In this study, instantly-soluble transmucosal matrices (ISTMs) of D, containing dual mechanism solubilizer (Pluronic F-127/citric acid mixture), were prepared by lyophilization technique to enhance matrix disintegration, dissolution and transmucosal permeation...
May 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26241752/novel-self-assembled-nano-tubular-mixed-micelles-of-pluronics-p123-pluronic-f127-and-phosphatidylcholine-for-oral-delivery-of-nimodipine-in-vitro-characterization-ex-vivo-transport-and-in-vivo-pharmacokinetic-studies
#4
Emad B Basalious, Rehab N Shamma
Subarachnoid hemorrhage (SAH) is a major cause of death in patients suffering from stroke. Nimodipine (NM) is the only FDA-approved drug for treating SAH-induced vasospasm. However, NM suffers from poor oral bioavailability (5-13%) due to its low aqueous solubility, extensive first pass metabolism and short elimination half-life (1-2h). The objective of this study was to develop NM-loaded Pluronic/phosphatidylcholine/polysorbate 80 mixed micelles (PPPMM) that can solubilize NM in aqueous media even after dilution, prolong its circulation time, improve its bioavailability and eventually help in targeting it to the brain tissue...
September 30, 2015: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26151106/tri-tetra-block-co-polymeric-nanocarriers-as-a-potential-ocular-delivery-system-of-lornoxicam-in-vitro-characterization-and-in-vivo-estimation-of-corneal-permeation
#5
Alaa Hamed Salama, Rehab Nabil Shamma
Polymeric micelles that can deliver drug to intended sites of the eye have attracted much scientific attention recently. The aim of this study was to evaluate the aqueous-based formulation of drug-loaded polymeric micelles that hold significant promise for ophthalmic drug delivery. This study investigated the synergistic performance of mixed polymeric micelles made of linear and branched poly(ethylene oxide)-poly(propylene oxide) for the more effective encapsulation of lornoxicam (LX) as a hydrophobic model drug...
August 15, 2015: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/25473283/follicular-delivery-of-spironolactone-via-nanostructured-lipid-carriers-for-management-of-alopecia
#6
Rehab Nabil Shamma, Mona Hassan Aburahma
Spironolactone (SL) is a US Food and Drug Administration-approved drug for the treatment of hypertension and various edematous conditions. SL has gained a lot of attention for treating androgenic alopecia due to its potent antiandrogenic properties. Recently, there has been growing interest for follicular targeting of drug molecules for treatment of hair and scalp disorders using nanocolloidal lipid-based delivery systems to minimize unnecessary systemic side effects associated with oral drug administration...
2014: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/24892631/design-of-freeze-dried-soluplus-polyvinyl-alcohol-based-film-for-the-oral-delivery-of-an-insoluble-drug-for-the-pediatric-use
#7
Rehab Shamma, Nermeen Elkasabgy
Spironolactone (SL) is a poorly water-soluble drug. Being poorly soluble affects its dissolution rate which in turn affects its oral bioavailability. This work aimed to prepare freeze-dried SL-Soluplus/polyvinyl alcohol (PVA) oral thin film in an attempt to enhance the drug solubility on one hand and at the same time prepare a solid dosage form convenient for the pediatric use. SL-Soluplus/PVA films were prepared using polyethylene glycol 400 (PEG 400) as a plasticizer applying the solvent-casting technique...
2016: Drug Delivery
https://www.readbyqxmd.com/read/23713516/transfersomal-lyophilized-gel-of-buspirone-hcl-formulation-evaluation-and-statistical-optimization
#8
Rehab Nabil Shamma, Ibrahim Elsayed
CONTEXT: Buspirone HCl has very low oral bioavailability (4%) due to deactivation by extensive first pass effect. It also has very limited transdermal permeation due to its high hydrophilicity. OBJECTIVE: The aim of this study was to increase the transdermal permeation of buspirone HCl utilizing a stable dosage form. METHODS: Transfersomes were prepared using Tween-80 as a flexibility imparting agent to the vesicular walls. Oleic acid and/or ethanol, with different percentages, were utilized as a permeation enhancer...
September 2013: Journal of Liposome Research
https://www.readbyqxmd.com/read/23607316/design-and-optimization-of-surfactant-based-nanovesicles-for-ocular-delivery-of-clotrimazole
#9
Mona Basha, Sameh Hosam Abd El-Alim, Rehab N Shamma, Ghada E A Awad
The objective of this study was to develop an efficient ocular nanovesicular carrier providing a controlled delivery of Clotrimazole (CLT); a water insoluble antifungal drug. The nanovesicular carriers were formulated using Span 60 with one of the following edge activators (EA): Tween 80 (TW80), sodium cholate (SC) or sodium deoxycholate (SDC). A 3(2) full factorial design was used to study the effect of two independent variables, namely, the type of EA and the ratio of Span 60 to EA. The effects of these parameters on the mean particle size, entrapment efficiency (EE) and zeta potential (ZP) were investigated as dependent variables...
September 2013: Journal of Liposome Research
https://www.readbyqxmd.com/read/22107175/development-and-optimization-of-lyophilized-orally-disintegrating-tablets-using-factorial-design
#10
Iman Saad Ahmed, Rehab Nabil Shamma, Ragia Ali Shoukri
The aim of this study was to evaluate the use of maltodextrin as a sugar-matrix former along with several cellulosic binders in the preparation of freeze-dried orally disintegrating tablets (ODT). The ODT was prepared by freeze-drying an aqueous dispersion of nimesulide (NM) containing maltodextrin and a cellulosic binder. The influence of formulation parameters on the in vitro/in vivo disintegration time and in vitro dissolution of NM from ODTs along with other tablet characteristics was investigated using full factorial design...
July 2013: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/21770719/development-of-novel-sustained-release-matrix-pellets-of-betahistine-dihydrochloride-effect-of-lipophilic-surfactants-and-co-surfactants
#11
Rehab Nabil Shamma, Emad B Basalious, Raguia Shoukri
Sustained release matrix pellets of the freely water soluble drug, betahistine dihydrochloride (BH), were prepared using freeze pelletization technique. Different waxes and lipids (cetyl alcohol, beeswax, glyceryl tripalmitate (GTP) and glyceryl tristearate) were evaluated for the preparation of matrix pellets. A D-optimal design was employed for the optimization and to explore the effect of drug loading (X(1)), concentration of lipophilic surfactant (X(2)), concentration of co-surfactant (X(3)) and wax type (X(4)) on the release extent of the drug from matrix pellets...
September 2012: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/21145958/development-and-optimization-of-a-multiple-unit-controlled-release-formulation-of-a-freely-water-soluble-drug-for-once-daily-administration
#12
Rehab N Shamma, Emad B Basalious, Raguia A Shoukri
A controlled release resinate beads of betahistine diHCl (BHCl), a short half-life freely water soluble drug, was developed to allow once-daily administration to improve patient compliance and eliminate the risk of intolerance of the drug. BHCl-resin complex was subsequently coated with Eudragit RS100. A 2(4) full factorial design was employed for optimization and to explore the effect of Eudragit RS100 concentration in the coating solution (X(1)), the coating percentage (X(2)), the speed of rotation (X(3)) and the concentration of plasticizer (PEG 400) (X(4)) on the release rate of the drug from the microcapsules...
February 28, 2011: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/19406232/in-vitro-and-in-vivo-evaluation-of-nimesulide-lyophilized-orally-disintegrating-tablets
#13
RANDOMIZED CONTROLLED TRIAL
Raguia Ali Shoukri, Iman Saad Ahmed, Rehab N Shamma
Development of a lyophilized orally disintegrating tablet (ODT) that enhanced the in vitro dissolution and in vivo absorption of nimesulide (NM), a drug with poor solubility and poor bioavailability, is presented. The ODTs were prepared by freeze-drying an aqueous dispersion of NM containing a matrix former, a sugar alcohol, and a collapse protectant. In addition, different disintegration accelerators were tested. The influence of formulation parameters on the disintegration time and in vitro dissolution of NM from ODTs along with other tablet characteristics was investigated...
September 2009: European Journal of Pharmaceutics and Biopharmaceutics
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