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gangrenosum pyoderma

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https://www.readbyqxmd.com/read/28528602/the-pathergy-test-as-a-diagnostic-tool
#1
Zekayi Kutlubay, Yalçın Tüzün, Ronni Wolf
The pathergy test produces a nonspecific hyperreactive lesion in Behçet's disease (BD), a finding that has been known since 1937. Pathergy refers to the development of new skin lesions or the aggravation of existing ones after trivial trauma. In clinical practice, the pathergy test induces a skin response by needleprick, with positive reactions manifesting as a papule or pustule developing by 48 hours. The pathergy test is one of the major features and diagnostic criteria of the disease. It is very similar to the erythematous papules or pustules that appear spontaneously in patients with BD...
2017: Skinmed
https://www.readbyqxmd.com/read/28525250/-unusual-association-between-auto-immune-hepatitis-and-pyoderma-gangrenosum-a-case-report
#2
X Vandemergel, M Lefebvre, I Focant, L Marot, D Ilisei
Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin. This entity is associated with systemic diseases and autoimmune diseases but exceptionally with autoimmune hepatitis. We report the case of a 40 year-old woman diagnosed with type 1 autoimmune hepatitis 12 years earlier and admitted for the appearance of an ulcerative lesion in the left leg. Histology confirmed pyoderma gangrenosum.
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28520320/-pathergic-postsurgical-induced-pyoderma-gangrenosum
#3
N Wirtzfeld, P Paquet, T Lemineur, M Lutgen, J-D Bouaziz, C Denoel
Pyoderma gangrenosum (PG) is a rare pustular and ulcerative inflammatory disease belonging to the group of neutrophilic dermatoses. It is frequently associated with systemic immune diseases. In this context the PG can be exceptionally triggered by tissue trauma such as surgery (pathergy). We report the case of a patient with stabilized rheumatoid arthritis who developed aggressive and disseminated PG at all surgical wounds following an abdominal dermolipectomy associated with breast pexy. Systemic corticosteroid methylprednisolone allowed a rapid control of skin ulcerations...
May 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28518224/t-helper-1-related-molecules-as-well-as-il-15-are-hyperexpressed-in-the-skin-lesions-of-patients-with-pyoderma-gangrenosum
#4
Emiliano Antiga, Roberto Maglie, Walter Volpi, Beatrice Bianchi, Emilio Berti, Angelo Valerio Marzano, Marzia Caproni
Pyoderma gangrenosum (PG) is a rare, immune-mediated skin disease classified into the group of neutrophilic dermatoses. Whether a number of studies confirmed the central role of innate immunity, only few studies investigated the possible contributing role of acquired immunity. In particular, no reports about Th1 and Th2 cells are available yet. Therefore, 15 patients with PG, 5 with Sweet's syndrome (SS) and 9 skin specimens from healthy controls (HC) were investigated, evaluating the expression of Th1-related markers IL-12, IFN-γ, CXCR3, CCR5, of the Th2 related molecules IL-4, IL-5, IL-13 and CCR3, of the co-stimulatory axis CD40/CD40L, of IL-15 and the NK cell marker CD56 in skin lesions by immunohistochemistry...
May 18, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28507842/pyoderma-gangrenosum-after-deep-inferior-epigastric-perforator-breast-reconstruction-systematic-review-and-case-report
#5
Justin T Zelones, John F Nigriny
BACKGROUND: Pyoderma gangrenosum (PG) is a rare skin disorder of the neutrophilic dermatoses spectrum that can mimic wound infections in surgical patients. PG after breast surgery has been reported but in limited amounts in autologous breast reconstruction patients. We present the first case of PG after a delayed bilateral deep inferior epigastric perforator flap breast reconstruction in the setting of systemic disease along with a systematic review. METHODS: PubMed, Ovid, and Web of Science were systematically searched to obtain cases of PG after autologous breast reconstruction...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28506054/-penile-tuberculosis-a-case-report
#6
Takahiro Imanaka, Hironori Nomura, Go Tsujimura, Yoko Ko, Takanori Kinjyo, Iwao Yoshioka, Shingo Takada, Yoko Yahata, Tetsu Mizutani
A 66-year-old man presented with a chief complaint of glans penis pain, induration, and discharge of pus. He was prescribed a course of antibiotics, but the condition persisted despite treatment. Thus, we differrentially diagnosed the patient with penile tuberculosis and pyoderma gangrenosum, and performed a biopsy of the penis. The biopsy result was thickening of the horny layer epidermis with only a foreign body granuloma composed of inflammatory cells, and did not lead to a definitive diagnosis. Thoraca-abdominal computed tomography revealed axillary lymphadenopathy with necrosis...
April 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28476284/pyoderma-gangrenosum-with-pathergy-a-potentially-significant-complication-following-breast-reconstruction
#7
D K Patel, M Locke, P Jarrett
The failure of postoperative surgical site infection to resolve after appropriate antibiotic therapy should alert the clinician to other diagnoses. Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis that is typically characterized by necrotizing ulceration. PG can be exacerbated by minor trauma leading to exaggerated skin injury, a condition known as pathergy. We present a case series of PG arising after immediate reconstruction for breast oncological surgery from 1st January 2006 to 1st September 2014...
April 12, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28470091/acute-cutaneous-necrosis-a-guide-to-early-diagnosis-and-treatment
#8
Karen Karimi, Ashika Odhav, Ramya Kollipara, Jesse Fike, Carol Stanford, John C Hall
Acute cutaneous necrosis is characterised by a wide range of aetiologies and is associated with significant morbidity and mortality, warranting complex considerations in management. Early recognition is imperative in diagnosis and management of sudden gangrenous changes in the skin. This review discusses major causes of cutaneous necrosis, examines the need for early assessment, and integrates techniques related to diagnosis and management. The literature, available via PubMed, on acute cutaneous necrotic syndromes was reviewed to summarise causes and synthesise appropriate treatment strategies to create a clinician's guide in the early diagnosis and management of acute cutaneous necrosis...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28468097/-acute-lymphoblastic-leukemia-complicated-with-pyoderma-gangrenosum-a-case-report-and-literatures-review
#9
X Shi, Z G Cui, F Hou, H Xu, H Wang, Z Su, H G Zhao
No abstract text is available yet for this article.
April 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28451012/-pyoderma-gangrenosum-of-the-scalp-about-a-case
#10
Békaye Traoré, Youssouf Fofana
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28443317/novel-use-of-apremilast-for-adjunctive-treatment-of-recalcitrant-pyoderma-gangrenosum
#11
Mary E Laird, Lana X Tong, Kristen I Lo Sicco, Randie H Kim, Shane A Meehan, Andrew G Franks
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28443308/plasmablasticlike-lymphoma-arising-within-chronic-pyoderma-gangrenosum
#12
Elaine Dupuis, Misha Zarbafian, Jessica Asgarpour, Laurie Parsons, P Régine Mydlarski
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28418207/pyoderma-gangrenosum-in-a-pregnant-patient-a-case-report-and-literature-review
#13
Naoki Takeshita, Akiko Takashima, Hiroaki Ishida, Megumi Manrai, Toshihiko Kinoshita
Pyoderma gangrenosum (PG) is a rare ulcerative skin disease that usually starts as a pustular lesion and rapidly progresses to a painful ulcer with undermined violaceous borders. The occurrence of PG during pregnancy is uncommon. We describe a case of a pregnant patient with PG who was diagnosed as having ulcerative colitis after delivery. Obstetricians need to understand the pathogenesis of PG and its associated conditions because it is important to make a proper diagnosis and provide targeted therapy.
April 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28409579/recalcitrant-cases-of-pyoderma-gangrenosum-responding-dramatically-to-systemic-tacrolimus
#14
Maryam S Sadati, Ladan Dastgheib, Elham Aflaki
Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous disease, without any well-known specific and effective treatment. Here we report two patients with severe recalcitrant perineal pyoderma gangrenosum, successfully treated with low dose systemic tacrolimus. Tacrolimus can be a safe effective drug in the management of recalcitrant PG.
June 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28400897/postsurgical-pyoderma-gangrenosum-following-carpal-tunnel-release-a-rare-disease-following-a-common-surgery
#15
Michael R Ruebhausen, Shaun D Mendenhall, Michael W Neumeister, Nada N Berry
Objective: Postsurgical pyoderma gangrenosum is a rare but potentially devastating condition for surgical patients. While pyoderma gangrenosum has 2 subtypes, typical and atypical, each can be further classified by its heralding features. These include ulcerative, pustular, bullous, and vegetative. The presentation can be a result of trauma or, as mentioned before, postsurgical. The plastic and reconstructive surgeon most likely will encounter postsurgical pyoderma gangrenosum in practice, as it has been reported in patient populations frequently seen in plastic surgery clinics...
2017: Eplasty
https://www.readbyqxmd.com/read/28392668/treatment-of-recalcitrant-pyoderma-gangrenosum-with-ulcerative-colitis-by-adalimumab-injection
#16
Jin-Hyup Lee, In-Kyu Chang, Hae-Eul Lee, Myung Im, Young-Joon Seo, Jeung-Hoon Lee, Young Lee
No abstract text is available yet for this article.
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28391619/ciclosporin-compared-to-prednisolone-therapy-for-patients-with-pyoderma-gangrenosum-cost-effectiveness-analysis-of-the-stop-gap-trial
#17
J M Mason, K S Thomas, A D Ormerod, F E Craig, E Mitchell, J Norrie, H C Williams
BACKGROUND: Pyoderma gangrenosum (PG) is a painful, ulcerating skin disease with poor evidence for management. Prednisolone and ciclosporin are the most commonly used treatments, although not previously compared within a randomised controlled trial (RCT) OBJECTIVES: To compare the cost-effectiveness of ciclosporin and prednisolone-initiated treatment for patients with PG. METHODS: Quality-of-life (EuroQoL EQ-5D-3L) and resource data were collected as part of the STOP-GAP trial: a multicentre, parallel-group, observer-blind RCT...
April 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28387826/clinical-update-on-inflammasomopathies
#18
Hafize Emine Sönmez, Seza Özen
Inflammasomes are important elements of the innate immune defense. The most common autoinflammatory syndromes, as well a number of rare ones, are due to hereditary defects in the inflammasomes, hence are called inflammasomopathies. The recent clinical advances in these diseases will be reviewed, with special emphasis on reflecting the international collaborative work in the field. Recent recommendations for familial Mediterranean fever (FMF), cryopyrin-associated periodic syndromes (CAPS) and hyper-IgD syndrome (HIDS) / mevalonate kinase deficiency (MKD) will be presented and diagnostics tests, treatment alternatives, and follow-up recommendations will be summarized...
April 6, 2017: International Immunology
https://www.readbyqxmd.com/read/28379857/postsurgical-pyoderma-gangrenosum-versus-necrotizing-fasciitis-can-we-spot-the-difference
#19
Leila L Touil, Dilnath A R Gurusinghe, Amir Sadri, Ahmed El-Gawad, Fahmy S Fahmy
BACKGROUND: Pyoderma gangrenosum is a rare noninfectious cutaneous disease characterized by expanding areas of skin ulceration around necrotic centers with purulent debris. Exceptionally, it can be precipitated by surgery alone, and this entity has been described as postsurgical pyoderma gangrenosum (PSPG). Cases of PSPG in the literature are rare. METHODS: We performed a retrospective review of the current literature on PSPG and highlight some observed differences between these conditions...
May 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28377868/a-case-of-breakthrough-candida-parapsilosis-fungemia-during-micafungin-therapy-for-a-candida-glabrata-bloodstream-infection
#20
Yuta Norimatsu, Daiichi Morii, Asako Kogure, Taeko Hamanaka, Yoshihiro Kuwano, Takayuki Yokozawa, Toshimi Oda
We describe a case of breakthrough Candida parapsilosis fungemia in an 80-year-old woman with pyoderma gangrenosum and rheumatoid arthritis. C. parapsilosis was detected in blood culture while the patient was treated with micafungin for a Candida glabrata bloodstream infection. The breakthrough infection was successfully treated with liposomal amphotericin B.
June 2017: Medical Mycology Case Reports
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