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hyperthermia in the elderly

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https://www.readbyqxmd.com/read/26795033/is-hyperthermia-combined-with-radiotherapy-adequate-in-elderly-patients-with-muscle-invasive-bladder-cancers-thermo-radiobiological-implications-from-an-audit-of-initial-results
#1
Niloy R Datta, Brigitte Eberle, Emsad Puric, Andreas Meister, Dietmar Marder, Olaf Tim, Anton Klimov, Stephan Bodis
PURPOSE: The aim of this study was to evaluate the outcomes of loco-regional hyperthermia (HT) with radiotherapy (RT) and/or chemotherapy (CT) in elderly patients with muscle-invasive bladder cancers (MIBC). MATERIAL AND METHODS: Twenty consecutive MIBC patients were treated with HTRT (n = 8) or HTCTRT (n = 12) following transurethral resection of their bladder tumours. Weekly HT was administered prior to RT to a mean temperature of 40.6-42.7 °C for 60 min...
June 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/26393633/predictive-factors-for-hospitalization-of-patients-with-heat-illness-in-yamaguchi-japan
#2
Takahiro Yamamoto, Masaki Todani, Yasutaka Oda, Tadashi Kaneko, Kotaro Kaneda, Motoki Fujita, Takashi Miyauchi, Ryosuke Tsuruta
The objective of the study was to investigate the predictive factors for the hospitalization of patients who presented with mild to moderate heat illness at an emergency department. We conducted a retrospective survey of hospitals with an emergency department in Yamaguchi Prefecture, Japan. The survey questionnaire entries included patient age, sex, use of an ambulance, vital signs, blood examination conducted at the emergency department, the length of hospitalization, and outcome. We analyzed the predictive factors for hospitalization in patients with heat illness...
September 2015: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/26140721/cerebral-vascular-control-and-metabolism-in-heat-stress
#3
REVIEW
Anthony R Bain, Lars Nybo, Philip N Ainslie
This review provides an in-depth update on the impact of heat stress on cerebrovascular functioning. The regulation of cerebral temperature, blood flow, and metabolism are discussed. We further provide an overview of vascular permeability, the neurocognitive changes, and the key clinical implications and pathologies known to confound cerebral functioning during hyperthermia. A reduction in cerebral blood flow (CBF), derived primarily from a respiratory-induced alkalosis, underscores the cerebrovascular changes to hyperthermia...
July 1, 2015: Comprehensive Physiology
https://www.readbyqxmd.com/read/26000973/photothermal-stress-triggered-by-near-infrared-irradiated-carbon-nanotubes-up-regulates-osteogenesis-and-mineral-deposition-in-tooth-extracted-sockets
#4
Hiroshi Kajiya, Yuri Katsumata, Mina Sasaki, Takashi Tsutsumi, Minoru Kawaguchi, Tadao Fukushima
PURPOSE: The bone regenerative healing process is often prolonged, with a high risk of infection particularly in elderly and diseased patients. A reduction in healing process time usually requires mechanical stress devices, chemical cues, or laser/thermal therapies. Although these approaches have been used extensively for the reduction of bone healing time, the exact mechanisms involved in thermal stress-induced bone regeneration remain unclear. METHODS: Photothermal stress (PTS) stimulation was carried out using a novel photothermal device, composed of an alginate gel (AG) including carbon nanotubes (CNT-AGs) and their irradiator with near-infrared (NIR) light...
2015: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/25993102/estimating-risks-of-heat-strain-by-age-and-sex-a-population-level-simulation-model
#5
Kathryn Glass, Peter W Tait, Elizabeth G Hanna, Keith Dear
Individuals living in hot climates face health risks from hyperthermia due to excessive heat. Heat strain is influenced by weather exposure and by individual characteristics such as age, sex, body size, and occupation. To explore the population-level drivers of heat strain, we developed a simulation model that scales up individual risks of heat storage (estimated using Myrup and Morgan's man model "MANMO") to a large population. Using Australian weather data, we identify high-risk weather conditions together with individual characteristics that increase the risk of heat stress under these conditions...
May 2015: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/25876664/the-effect-of-repetitive-mild-hyperthermia-on-body-temperature-the-autonomic-nervous-system-and-innate-and-adaptive-immunity
#6
Chikako Tomiyama, Mayumi Watanabe, Takashi Honma, Akihiro Inada, Takayoshi Hayakawa, Masae Ryufuku, Toru Abo
The effect of repetitive mild hyperthermia on body temperature, the autonomic nervous system, and innate and adaptive immunity was investigated using a new hyperthermia treatment system, nanomist sauna (NMS). Six healthy volunteers participated and the concentration of catecholamines and cortisol, and the frequency and function of leukocytes in the peripheral blood were investigated before and after successive 7 days of hyperthermia treatment (20 min/day, 40°C, 100% relative humidity). After treatment, the blood level of adrenaline and cortisol on the 7th day was decreased compared with the 1st day, indicating the suppression of the sympathetic nervous system activity...
2015: Biomedical Research
https://www.readbyqxmd.com/read/25675854/hyperthermic-intraperitoneal-chemotherapy-for-the-treatment-of-recurrent-ovarian-cancer-in-elderly-women
#7
Jérôme Delotte, Tatiana Arias, Olivier Guerin, Rabia Boulahssass, Isabelle Bereder, André Bongain, Daniel Benchimol, Jean Marc Bereder
Our aim was to evaluate the morbidity and survival associated with combined cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of recurrent ovarian cancer for patients aged 70 years and older. We conducted a monocentric study in a French university hospital and collected data on 15 women aged ≥ 70 years, treated by cytoreduction and HIPEC for ovarian cancer relapse. The median overall survival was 35 months, with a median disease-free survival of 15.6 months. When a Peritoneal Cancer Index subgroup analysis was performed, a statistically significant difference in the disease-free survival could be observed for a Peritoneal Cancer Index ≤ 13 (p = 0...
April 2015: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/25336291/photothermal-stress-triggered-by-near-infrared-irradiated-carbon-nanotubes-promotes-bone-deposition-in-rat-calvarial-defects
#8
Tsukasa Yanagi, Hiroshi Kajiya, Minoru Kawaguchi, Hirofumi Kido, Tadao Fukushima
The bone regenerative healing process is often prolonged, with a high risk of infection particularly in elderly and diseased patients. A reduction in healing process time usually requires mechanical stress devices, chemical cues, or laser/thermal therapies. Although these approaches have been used extensively for the reduction of bone healing time, the exact mechanisms involved in thermal stress-induced bone regeneration remain unclear. In this study, we investigated the effect of optimal hyperthermia on rat calvarial defects in vivo and on osteogenesis in vitro...
March 2015: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/25268103/cardiovascular-adaptation-to-mudpack-therapy-in-hypertensive-subjects-treated-with-different-antihypertensive-drugs
#9
G Merati, L Agnello, S Rampichini, M A Maggioni, R Scurati, A Veicsteinas
OBJECTIVE: In selected hypertensive subjects, cardiovascular adaptation to warm environments may be inadequate or even harmful: heating associated to mudpack therapy may cause unexpected hypotension. How different antihypertensive drugs may affect the cardiovascular response to mudpack therapy is poorly studied. AIMS: To evaluate the effects of β-blockers and angiotensin II receptor antagonists/ACE inhibitors on the acute cardiovascular adaptation to mudpack treatment in SPA in elderly hypertensive patients...
2014: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/24971182/malignant-hyperthermia-during-thoracoscopic-pulmorrhaphy-in-a-70-year-old-man
#10
Michihiro Sakai, Noriko Murakami, Yuji Kitamura, Shin Sato, Hiroshi Iwama, Akira Nomura
Malignant hyperthermia (MH) is a rare but potentially fatal complication that may develop under general anesthesia (GA) and is rarely reported in elderly patients. We encountered a case of mild-onset MH in a 70-year-old patient who was receiving an elective thoracoscopic pulmorrhaphy and had a history of several GA procedures. Anesthesia was induced with propofol, fentanyl, and rocuronium and maintained with sevoflurane and remifentanil. His body temperature (BT) was 37.9°C after induction. During the procedure, the end-tidal CO2 (ETCO2) increased steadily to 47-50 mmHg, presumably in response to the single lung ventilation...
2014: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/24809147/cytoreductive-surgery-and-hipec-for-peritoneal-carcinomatosis-in-the-elderly
#11
COMPARATIVE STUDY
J D Spiliotis, E Halkia, V A Boumis, D T Vassiliadou, A Pagoulatou, E Efstathiou
BACKGROUND: The combined treatment of peritoneal carcinomatosis with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is a rigorous surgical treatment, most suitable for young and good performance status patients. We evaluated the outcomes of elderly patients undergoing CRS and HIPEC for peritoneal carcinomatosis with careful perioperative care. METHODS: All consecutive patients 70 years of age or older who were treated for peritoneal carcinomatosis over the past five years were included...
2014: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/24319883/respect-your-elders-special-considerations-for-ems-response-to-geriatric-patients
#12
REVIEW
Keith Widmeier
A variety of chronic pathologies often come along with the aging process and are experienced by many patients in late adulthood. EMS providers must be aware of the various challenges of transporting the geriatric population. And although an emphasis is often placed on the physical and medical issues associated with this population, it's also imperative to look at the whole picture to help prevent issues before they become an emegent problem. This includes being vigilant for elder abuse and neglect, as well as potential home hazards-including fall potentials and maintaining colder home temperatures-and dangerous cost-cutting measures, such as sharing medications...
August 2013: JEMS: a Journal of Emergency Medical Services
https://www.readbyqxmd.com/read/23827047/outcomes-for-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-the-elderly
#13
REVIEW
Parissa Tabrizian, Ghalib Jibara, Brian Shrager, Bernardo Franssen, Ming-Jim Yang, Umut Sarpel, Spiros Hiotis, Daniel Labow
BACKGROUND: Cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC) has gained acceptance in the treatment of peritoneal carcinomatosis (PC) with reported morbidity and mortality rates of 27-56% and 0-11% respectively. The safety and outcome of such major operation in the elderly remains unclear. We report our experience at a high volume tertiary center. METHOD: A total of 170 consecutive patients underwent CRS-HIPEC for peritoneal carcinomatosis between March 2007 and July 2012...
September 2013: Surgical Oncology
https://www.readbyqxmd.com/read/23780382/outcomes-of-cytoreductive-surgery-crs-with-hyperthermic-intraperitoneal-chemotherapy-hipec-in-patients-older-than-70-years-survival-benefit-at-considerable-morbidity-and-mortality
#14
Konstantinos I Votanopoulos, Naeem A Newman, Greg Russell, Chukwuemeka Ihemelandu, Perry Shen, John H Stewart, Edward A Levine
BACKGROUND: Cytoreductive surgery (CRS)/Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is associated with prolonged survival in selected patients with peritoneal surface disease. Yet, for elderly patients (older than 70 years of age) CRS/HIPEC is controversial, due to associated morbidity. METHODS: A retrospective analysis of a prospective database of 950 procedures was performed. Type of malignancy, demographics, performance and resection status, hospitalization, morbidity, mortality, and survival were reviewed...
October 2013: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/23173816/electrochemotherapy-of-cutaneous-metastastes-from-breast-cancer-in-elderly-patients-a-preliminary-report
#15
Raffaella Benevento, Antonio Santoriello, Giuseppe Perna, Silvestro Canonico
BACKGROUND: The management of cutaneous metastases often represents a challenge because they may be widespread and may recur after radiotherapy or chemotherapy; breast cancer accounts for 51% of the total cases of cutaneous metastases. When surgical excision of chest wall recurrences is not possible and other local treatments such as radiotherapy or radiotherapy with hyperthermia fail, topical chemotherapy and electrochemotherapy (ECT) might be taken into account.ECT is a new local treatment of solid tumors which can be defined as the local potentiation, by means of permeabilizing electric pulses, of the antitumor activity of a non permeating anticancer drug with high intrinsic cytotoxicity...
2012: BMC Surgery
https://www.readbyqxmd.com/read/22858419/pathological-fracture-of-the-mandible-in-a-paediatric-patient-with-congenital-insensitivity-to-pain-with-anhidrosis-cipa
#16
Esther Manor, Ben Zion Joshua, Jacov Levy, Peter A Brennan, Lipa Bodner
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare hereditary sensory and autonomic neuropathy (HSAN) characterized by pain, self-mutilating behaviour, anhidrosis and recurrent hyperthermia. CIPA has a multisystem involvement, including fractures of the extremities with slow healing, immunologic abnormalities, and a chronic inflammatory state. The mandible is reported to have a higher incidence of osteomyelitis, though mandibular fracture among CIPA patients, is very rare, with to our knowledge no reports in children...
March 2013: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/22223659/forkhead-transcription-factor-foxa1-regulates-sweat-secretion-through-bestrophin-2-anion-channel-and-na-k-cl-cotransporter-1
#17
Chang-Yi Cui, Victoria Childress, Yulan Piao, Marc Michel, Adiv A Johnson, Makoto Kunisada, Minoru S H Ko, Klaus H Kaestner, Alan D Marmorstein, David Schlessinger
Body temperature is maintained in a narrow range in mammals, primarily controlled by sweating. In humans, the dynamic thermoregulatory organ, comprised of 2-4 million sweat glands distributed over the body, can secrete up to 4 L of sweat per day, thereby making it possible to withstand high temperatures and endure prolonged physical stress (e.g., long-distance running). The genetic basis for sweat gland function, however, is largely unknown. We find that the forkhead transcription factor, FoxA1, is required to generate mouse sweating capacity...
January 24, 2012: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/21856080/electrochemotherapy-of-chest-wall-breast-cancer-recurrence
#18
REVIEW
Gregor Sersa, Tanja Cufer, Snezna Marija Paulin, Maja Cemazar, Marko Snoj
Chest wall breast cancer recurrence after mastectomy is a disease difficult to treat. Its incidence varies between 5% and 30% in different subset of patients. When possible, radical surgical therapy represents the main treatment approach, however when the disease progresses and/or treatments are not successful, ulceration, bleeding, lymphedema and psychological distress of progressive disease significantly decrease the quality of the remaining life of a patient. When surgical excision of chest wall recurrence is not possible, other local treatments such as radiotherapy, radiotherapy with hyperthermia, topical chemotherapy and electrochemotherapy might be taken into account...
August 2012: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/21822376/comparison-of-two-treatments-for-coxarthrosis-local-hyperthermia-versus-radio-electric-asymmetrical-brain-stimulation
#19
COMPARATIVE STUDY
Alessandro Castagna, Salvatore Rinaldi, Vania Fontani, Piero Mannu, Matteo Lotti Margotti
BACKGROUND: It is well known that psychological components are very important in the aging process and may also manifest in psychogenic movement disorders, such as coxarthrosis. This study analyzed the medical records of two similar groups of patients with coxarthrosis (n = 15 in each) who were treated in two different clinics for rehabilitation therapy. METHODS: Patients in Group A were treated with a course of traditional physiotherapy, including sessions of local hyperthermia...
2011: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/21780124/outcomes-of-elderly-patients-undergoing-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-colorectal-cancer-peritoneal-carcinomatosis
#20
Yvonne L B Klaver, Terence C Chua, Ignace H J T de Hingh, David L Morris
BACKGROUND: The combined treatment of cytoreductive surgery (CRS) and perioperative chemotherapy (PIC) for colorectal peritoneal carcinomatosis (PC) is a rigorous surgical treatment most suited for fit and young patients. With technical maturity and improved perioperative care, we examined the outcomes of elderly patients undergoing CRS and PIC for colorectal PC. METHODS: All consecutive patients treated in two tertiary centers for PC of colorectal cancer who were 70 years of age or older at the time of surgery were included...
February 2012: Journal of Surgical Oncology
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