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nac transcription factor

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https://www.readbyqxmd.com/read/29144390/rna-sequencing-and-coexpression-analysis-reveal-key-genes-involved-in-%C3%AE-linolenic-acid-biosynthesis-in-perilla-frutescens-seed
#1
Tianyuan Zhang, Chi Song, Li Song, Zhiwei Shang, Sen Yang, Dong Zhang, Wei Sun, Qi Shen, Degang Zhao
Perillafrutescen is used as traditional food and medicine in East Asia. Its seeds contain high levels of α-linolenic acid (ALA), which is important for health, but is scarce in our daily meals. Previous reports on RNA-seq of perilla seed had identified fatty acid (FA) and triacylglycerol (TAG) synthesis genes, but the underlying mechanism of ALA biosynthesis and its regulation still need to be further explored. So we conducted Illumina RNA-sequencing in seven temporal developmental stages of perilla seeds...
November 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29136005/a-17-molecule-set-as-a-predictor-of-complete-response-to-neoadjuvant-chemotherapy-with-docetaxel-cisplatin-and-5-fluorouracil-in-esophageal-cancer
#2
Hajime Fujishima, Shoichi Fumoto, Tomotaka Shibata, Kohei Nishiki, Yoshiyuki Tsukamoto, Tsuyoshi Etoh, Masatsugu Moriyama, Norio Shiraishi, Masafumi Inomata
BACKGROUND: Recently, neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (NAC-DCF) was identified as a novel strong regimen with a high rate of pathological complete response (pCR) in advanced esophageal cancer in Japan. Predicting pCR will contribute to the therapeutic strategy and the prevention of surgical invasion. However, a predictor of pCR after NAC-DCF has not yet been developed. The aim of this study was to identify a novel predictor of pCR in locally advanced esophageal cancer treated with NAC-DCF...
2017: PloS One
https://www.readbyqxmd.com/read/29133368/transcription-factors-vnd1-vnd3-contribute-to-cotyledon-xylem-vessel-formation
#3
Tian Tian Tan, Hitoshi Endo, Ryosuke Sano, Tetsuya Kurata, Masatoshi Yamaguchi, Misato Ohtani, Taku Demura
Arabidopsis thaliana VASCULAR-RELATED NAC-DOMAIN1 (VND1) to VND7 encode a group of NAC domain transcription factors that function as master regulators of xylem vessel element differentiation. These transcription factors activate the transcription of genes required for secondary cell wall formation and programmed cell death - key events in xylem vessel element differentiation. Because constitutive overexpression of VND6 and VND7 induces ectopic xylem vessel element differentiation, functional studies of VND proteins have largely focused on these two proteins...
November 13, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29131830/transcriptome-profiling-and-digital-gene-expression-analysis-of-sweet-potato-for-the-identification-of-putative-genes-involved-in-the-defense-response-against-fusarium-oxysporum-f-sp-batatas
#4
Yuli Lin, Weikun Zou, Shiqiang Lin, Dennis Onofua, Zhijian Yang, Haizhou Chen, Songliang Wang, Xuanyang Chen
Sweet potato production is constrained by Fusarium wilt, which is caused by Fusarium oxysporum f. sp. batatas (Fob). The identification of genes related to disease resistance and the underlying mechanisms will contribute to improving disease resistance via sweet potato breeding programs. In the present study, we performed de novo transcriptome assembly and digital gene expression (DGE) profiling of sweet potato challenged with Fob using Illumina HiSeq technology. In total, 89,944,188 clean reads were generated from 12 samples and assembled into 101,988 unigenes with an average length of 666 bp; of these unigenes, 62,605 (61...
2017: PloS One
https://www.readbyqxmd.com/read/29122985/tsnac1-is-a-key-transcription-factor-in-abiotic-stress-resistance-and-growth
#5
Can Liu, Baomei Wang, Zhaoxia Li, Zhenghua Peng, Juren Zhang
NAC proteins constitute one of the largest families of plant-specific transcription factors, and a number of these proteins participate in the regulation of plant development and responses to abiotic stress. T. HALOPHILA STRESS RELATED NAC1 (TsNAC1) cloned from the halophyte Thellungiella halophila is a NAC transcription factor gene, and its overexpression can improve abiotic stress resistance, especially in the salt stress tolerance, in both T. halophila and Arabidopsis and retard the growth of these plants...
November 9, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29115926/co-expression-network-analysis-of-the-transcriptomes-of-rice-roots-exposed-to-various-cadmium-stresses-reveals-universal-cadmium-responsive-genes
#6
Mingpu Tan, Dan Cheng, Yuening Yang, Guoqiang Zhang, Mengjie Qin, Jun Chen, Yahua Chen, Mingyi Jiang
BACKGROUND: The migration of cadmium (Cd) from contaminated soil to rice is a cause for concern. However, the molecular mechanism underlying the response of rice roots to various Cd stresses remains to be clarified from the viewpoint of the co-expression network at a system-wide scale. RESULTS: We employed a comparative RNAseq-based approach to identify early Cd-responsive differentially expressed genes (DEGs) in rice 'Nipponbare' seedling roots after 1 h of high-Cd treatment...
November 7, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29115506/angiotensin-ii-induces-monocyte-chemoattractant-protein%C3%A2-1-expression-by-increasing-reactive-oxygen-species%C3%A2-mediated-activation-of-the-nuclear-factor%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-osteoblasts
#7
Changyao Wang, Cailong Zhang, Feng Zhou, Lei Gao, Yingzhen Wang, Chunsheng Wang, Yongtao Zhang
The present study investigated the effect of angiotensin II (Ang II) on monocyte chemoattractant protein‑1 (MCP‑1) expression and the underlying mechanism in osteoblasts. MCP‑1 expression levels were analyzed by ELISA and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Ang II type 1 receptor (AT1R) expression levels was examined by RT‑qPCR, western blotting and immunostaining. In addition, the nuclear factor (NF)‑κB signaling pathway was investigated via western blot analysis...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29105766/the-cotton-gossypium-hirsutum-nac-transcription-factor-fsn1-as-a-positive-regulator-participates-in-controlling-secondary-cell-wall-biosynthesis-and-modification-of-fibers
#8
Jie Zhang, Geng-Qing Huang, Dan Zou, Jing-Qiu Yan, Yang Li, Shan Hu, Xue-Bao Li
Cotton (Gossypium hirsutum) fibers are the highly elongated and thickened single-cell trichomes on the seed epidermis. However, little is known about the molecular base of fiber cell wall thickening in detail. In this study, a cotton NAC transcription factor (GhFSN1) that is specifically expressed in secondary cell wall (SCW) thickening fibers was functionally characterized. The GhFSN1 transgenic cotton plants were generated to study how FSN1 regulates fiber SCW formation. Up-regulation of GhFSN1 expression in cotton resulted in an increase in SCW thickness of fibers but a decrease in fiber length...
November 6, 2017: New Phytologist
https://www.readbyqxmd.com/read/29100904/nicotine-induced-creb-and-deltafosb-activity-is-modified-by-caffeine-in-the-brain-reward-system-of-the-rat
#9
Przemysław Kowiański, Grażyna Lietzau, Aleksandra Steliga, Ewelina Czuba, Beata Ludkiewicz, Monika Waśkow, Jan H Spodnik, Janusz Moryś
Coffee and nicotine consumption are frequently combined, indicating possible intensifying effect of caffeine on smoking behavior, although neurobiological background of this phenomenon remains unknown. We aimed at determining the effect of caffeine and nicotine, applied separately or simultaneously, on activation of six structures of the brain reward system: nucleus accumbens (NAc), ventral tegmental area (VTA), amygdala (Amg), hippocampus (Hip), medial prefrontal cortex (mPfr) and dorsal striatum (CdP) in the adult male Wistar rats...
November 1, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29082320/%C3%AE-9-tetrahydrocannabinol-experience-influences-%C3%AE-fosb-and-downstream-gene-expression-in-prefrontal-cortex
#10
Matthew F Lazenka, Minho Kang, Dipanjana Datta De, Dana E Selley, Laura J Sim-Selley
Introduction: Repeated administration of abused drugs, including Δ(9)-tetrahydrocannabinol (THC), induces the stable transcription factor ΔFosB in dopaminergic terminal field regions of the mesolimbic system. These studies investigated the effect of prior repeated THC treatment on THC-induced ΔFosB expression and regulation of downstream targets in the forebrain. Methods: Mice received THC (10 mg/kg) or vehicle twice daily for 13 days, and then half of each group received a single injection of THC or vehicle 45 min before brain collection...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29079898/overexpression-of-a-predominantly-root-expressed-nac-transcription-factor-in-wheat-roots-enhances-root-length-biomass-and-drought-tolerance
#11
Dandan Chen, Shoucheng Chai, C Lynne McIntyre, Gang-Ping Xue
TaRNAC1 is a constitutively and predominantly root-expressed NAC transcription factor. TaRNAC1 overexpression in wheat roots confers increased root length, biomass and drought tolerance and improved grain yield under water limitation. A large and deep root system is an important trait for yield sustainability of dryland cereal crops in drought-prone environments. This study investigated the role of a predominantly root-expressed NAC transcription factor from wheat (TaRNAC1) in the root growth. Expression analysis showed that TaRNAC1 was a constitutively expressed gene with high level expression in the roots and was not drought-upregulated...
October 27, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/29078399/reciprocal-cross-regulation-of-vnd-and-snd-multigene-tf-families-for-wood-formation-in-populus-trichocarpa
#12
Ying-Chung Jimmy Lin, Hao Chen, Quanzi Li, Wei Li, Jack P Wang, Rui Shi, Sermsawat Tunlaya-Anukit, Peng Shuai, Zhifeng Wang, Hongyan Ma, Huiyu Li, Ying-Hsuan Sun, Ronald R Sederoff, Vincent L Chiang
Secondary cell wall (SCW) biosynthesis is the biological process that generates wood, an important renewable feedstock for materials and energy. NAC domain transcription factors, particularly Vascular-Related NAC-Domain (VND) and Secondary Wall-Associated NAC Domain (SND) proteins, are known to regulate SCW differentiation. The regulation of VND and SND is important to maintain homeostasis for plants to avoid abnormal growth and development. We previously identified a splice variant, PtrSND1-A2(IR) , derived from PtrSND1-A2 as a dominant-negative regulator, which suppresses the transactivation of all PtrSND1 family members...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29059200/de-novo-rna-sequencing-transcriptome-of-rhododendron-obtusum-identified-the-early-heat-response-genes-involved-in-the-transcriptional-regulation-of-photosynthesis
#13
Linchuan Fang, Jun Tong, Yanfang Dong, Dongyun Xu, Jing Mao, Yuan Zhou
Rhododendron spp. is an important ornamental species that is widely cultivated for landscape worldwide. Heat stress is a major obstacle for its cultivation in south China. Previous studies on rhododendron principally focused on its physiological and biochemical processes, which are involved in a series of stress tolerance. However, molecular or genetic properties of rhododendron's response to heat stress are still poorly understood. The phenotype and chlorophyll fluorescence kinetics parameters of four rhododendron cultivars were compared under normal or heat stress conditions, and a cultivar with highest heat tolerance, "Yanzhimi" (R...
2017: PloS One
https://www.readbyqxmd.com/read/29055697/cocaine-alters-homer1-natural-antisense-transcript-in-the-nucleus-accumbens
#14
Gregory C Sartor, Samuel K Powell, Dmitry Velmeshev, David Y Lin, Marco Magistri, Hannah J Wiedner, Andrea M Malvezzi, Nadja S Andrade, Mohammad A Faghihi, Claes Wahlestedt
Natural antisense transcripts (NATs) are an abundant class of long noncoding RNAs that have recently been shown to be key regulators of chromatin dynamics and gene expression in nervous system development and neurological disorders. However, it is currently unclear if NAT-based mechanisms also play a role in drug-induced neuroadaptations. Aberrant regulation of gene expression is one critical factor underlying the long-lasting behavioral abnormalities that characterize substance use disorder, and it is possible that some drug-induced transcriptional responses are mediated, in part, by perturbations in NAT activity...
October 18, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29049296/genome-wide-expression-analysis-of-salt-stressed-diploid-and-autotetraploid-paulownia-tomentosa
#15
Zhenli Zhao, Yongsheng Li, Haifang Liu, Xiaoqiao Zhai, Minjie Deng, Yanpeng Dong, Guoqiang Fan
Paulownia tomentosa is a fast-growing tree species with multiple uses. It is grown worldwide, but is native to China, where it is widely cultivated in saline regions. We previously confirmed that autotetraploid P. tomentosa plants are more stress-tolerant than the diploid plants. However, the molecular mechanism underlying P. tomentosa salinity tolerance has not been fully characterized. Using the complete Paulownia fortunei genome as a reference, we applied next-generation RNA-sequencing technology to analyze the effects of salt stress on diploid and autotetraploid P...
2017: PloS One
https://www.readbyqxmd.com/read/29040725/protein-s-nitrosylation-regulates-xylem-vessel-cell-differentiation-in-arabidopsis
#16
Harunori Kawabe, Misato Ohtani, Tetsuya Kurata, Tomoaki Sakamoto, Taku Demura
Post-translational modifications of proteins have important roles in the regulation of protein activity. One such modification, S-nitrosylation, involves the covalent binding of nitric oxide (NO)-related species to a cysteine residue. Recent work showed that protein S-nitrosylation has crucial functions in plant development and environmental responses. In the present study, we investigated the importance of protein S-nitrosylation for xylem vessel cell differentiation using a forward-genetics approach. We performed ethyl methanesulfonate mutagenesis of a transgenic Arabidopsis 35S::VND7-VP16-GR line in which the activity of VASCULAR-RELATED NAC-DOMAIN7 (VND7), a key transcription factor involved in xylem vessel cell differentiation, can be induced posttranslationally by glucocorticoid treatment, with the goal of obtaining suppressor mutants that failed to differentiate ectopic xylem vessel cells; we named these mutants suppressor of ectopic vessel cell differentiation induced by VND7 (seiv) mutants...
October 13, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29039754/the-nac-transcription-factor-gene-osy37-onac011-promotes-leaf-senescence-and-accelerates-heading-time-in-rice
#17
Yousra El Mannai, Kenta Akabane, Keiichiro Hiratsu, Namiko Satoh-Nagasawa, Hiroetsu Wabiko
Leaf senescence is an important physiological process involving the degradation of a number of metabolites and their remobilization to new reproductive and storage organs. NAC (NAM, ATAF, and CUC) transcription factors are reported as important regulators of the senescence process. Here, we describe the identification and functional characterization of the NAC transcription factor gene, OsY37 (Oryza sativa Yellow37, ONAC011) obtained from Oryza sativa cv. indica, and japonica. We created transgenic plants expressing the OsY37 gene under the control of a strong and constitutive CaMV35S promoter...
October 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29030974/dopamine-transporter-gene-methylation-is-associated-with-nucleus-accumbens-activation-during-reward-processing-in-healthy-but-not-alcohol-dependent-individuals
#18
Christine Muench, Corinde E Wiers, Carlos R Cortes, Reza Momenan, Falk W Lohoff
BACKGROUND: Alcohol's reinforcement is mediated by dopamine signaling in the ventral striatum, which is modulated by the dopamine transporter (DAT). We hypothesized that methylomic variation in the DAT gene (SLC6A3) affects DAT expression thus contributing to differences in brain reward circuitry in individuals with alcohol dependence (ALC). METHODS: Blood from 45 recently detoxified ALC and 45 healthy control (HC) individuals was used to assess DNA methylation across 5 functional regions of SLC6A3...
October 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29024663/role-of-the-astroglial-glutamate-exchanger-xct-in-ventral-hippocampus-in-resilience-to-stress
#19
Carla Nasca, Benedetta Bigio, Danielle Zelli, Paolo de Angelis, Timothy Lau, Masahiro Okamoto, Hideyo Soya, Jason Ni, Lars Brichta, Paul Greengard, Rachael L Neve, Francis S Lee, Bruce S McEwen
We demonstrate that stress differentially regulates glutamate homeostasis in the dorsal and ventral hippocampus and identify a role for the astroglial xCT in ventral dentate gyrus (vDG) in stress and antidepressant responses. We provide an RNA-seq roadmap for the stress-sensitive vDG. The transcription factor REST binds to xCT promoter in co-occupancy with the epigenetic marker H3K27ac to regulate expression of xCT, which is also reduced in a genetic mouse model of inherent susceptibility to depressive-like behavior...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29023561/expression-patterns-and-promoter-analyses-of-aluminum-responsive-nac-genes-suggest-a-possible-growth-regulation-of-rice-mediated-by-aluminum-hormones-and-nac-transcription-factors
#20
Hugo Fernando Escobar-Sepúlveda, Libia Iris Trejo-Téllez, Soledad García-Morales, Fernando Carlos Gómez-Merino
In acid soils, the solubilized form of aluminum, Al+3, decreases root growth and affects the development of most crops. However, like other toxic elements, Al can have hormetic effects on plant metabolism. Rice (Oryza sativa) is one of the most tolerant species to Al toxicity, and when this element is supplied at low doses, growth stimulation has been observed, which could be due to combined mechanisms that are partly triggered by NAC transcription factors. This protein family can regulate vital processes in plants, including growth, development, and response to environmental stimuli, whether biotic or abiotic...
2017: PloS One
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