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nac transcription factor

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https://www.readbyqxmd.com/read/27900814/effects-of-intratracheal-exposure-of-2-chloroethyl-ethyl-sulfide-cees-on-the-activation-of-ccaat-enhancer-binding-protein-c-ebp-and-its-protection-by-antioxidant-liposome
#1
Somdutta Sinha Roy, Shyamali Mukherjee, Salil K Das
Exposure of 2-chloroethyl ethyl sulfide (CEES) to guinea pigs causes lung injury by infiltration of neutrophils in interstitial lung spaces. A unique MAPK-regulated transcription factor, C/EBP (CCAAT-enhancer-binding protein), regulates the expression of intracellular adhesion molecule-1 (ICAM-1), involved in recruiting neutrophils in lung. The present study was to determine if CEES exposure causes activation of C/EBP, in particular the predominant β-isoform and if so whether it can be prevented by intratracheal delivery of an antioxidant liposome containing N-acetyl cysteine and tocopherols...
November 30, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27872632/three-rice-nac-transcription-factors-heteromerize-and-are-associated-with-seed-size
#2
Iny Elizebeth Mathew, Sweta Das, Arunima Mahto, Pinky Agarwal
NACs are plant-specific transcription factors (TFs) involved in multiple aspects of development and stress. In rice, three NAC TF encoding genes, namely ONAC020, ONAC026, and ONAC023 express specifically during seed development, at extremely high levels. They exhibit significantly strong association with seed size/weight with the sequence variations located in the upstream regulatory region. Concomitantly, their expression pattern/levels during seed development vary amongst different accessions with variation in seed size...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27861553/activity-based-anorexia-alters-the-expression-of-bdnf-transcripts-in-the-mesocorticolimbic-reward-circuit
#3
Emily V Ho, Stephanie J Klenotich, Matthew S McMurray, Stephanie C Dulawa
Anorexia nervosa (AN) is a complex eating disorder with severe dysregulation of appetitive behavior. The activity-based anorexia (ABA) paradigm is an animal model in which rodents exposed to both running wheels and scheduled feeding develop aspects of AN including paradoxical hypophagia, dramatic weight loss, and hyperactivity, while animals exposed to only one condition maintain normal body weight. Brain-derived neurotrophic factor (BDNF), an activity-dependent modulator of neuronal plasticity, is reduced in the serum of AN patients, and is a known regulator of feeding and weight maintenance...
2016: PloS One
https://www.readbyqxmd.com/read/27860167/jrwrky2-and-jrwrky7-of-juglans-regia-mediate-responses-to-abiotic-stresses-and-abscisic-acid-by-formation-of-homodimers-and-interaction
#4
Guiyan Yang, Wenhui Zhang, Zexing Liu, A-Yijiamali Yi-Maer, Meizhi Zhai, Zhenggang Xu
[Backgroud] WRKY transcription factors (TFs) belong to a large protein family that is involved in diverse developmental processes and abiotic stress responses. Currently, there is little understanding of the role of WRKY TFs in regulatory mechanisms in plants, especially in the protein-protein interactions that are essential for biological regulatory functions and networks. [Methods] In the present study, the yeast one-hybrid, yeast two-hybrid, transient expression and quantitative RT-PCR were applied to investigate the potential characters of two WRKY proteins from Juglans regia, JrWRKY2 (GenBank No...
November 11, 2016: Plant Biology
https://www.readbyqxmd.com/read/27855193/transcriptome-wide-identification-and-expression-analysis-of-the-nac-gene-family-in-tea-plant-camellia-sinensis-l-o-kuntze
#5
Yong-Xin Wang, Zhi-Wei Liu, Zhi-Jun Wu, Hui Li, Jing Zhuang
In plants, the NAC (NAM-ATAF1/2-CUC) family of proteins constitutes several transcription factors and plays vital roles in diverse biological processes, such as growth, development, and adaption to adverse factors. Tea, as a non-alcoholic drink, is known for its bioactive ingredients and health efficacy. Currently, knowledge about NAC gene family in tea plant remains very limited. In this study, a total of 45 CsNAC genes encoding NAC proteins including three membrane-bound members were identified in tea plant through transcriptome analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27833618/depletion-of-key-meiotic-genes-and-transcriptome-wide-abiotic-stress-reprogramming-mark-early-preparatory-events-ahead-of-apomeiotic-transition
#6
Jubin N Shah, Olga Kirioukhova, Pallavi Pawar, Muhammad Tayyab, Juan L Mateo, Amal J Johnston
Molecular dissection of apomixis - an asexual reproductive mode - is anticipated to solve the enigma of loss of meiotic sex, and to help fixing elite agronomic traits. The Brassicaceae genus Boechera comprises of both sexual and apomictic species, permitting comparative analyses of meiotic circumvention (apomeiosis) and parthenogenesis. Whereas previous studies reported local transcriptome changes during these events, it remained unclear whether global changes associated with hybridization, polyploidy and environmental adaptation that arose during evolution of Boechera might serve as (epi)genetic regulators of early development prior apomictic initiation...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27832742/comparative-transcriptome-profiling-of-the-fertile-and-sterile-flower-buds-of-a-dominant-genic-male-sterile-line-in-sesame-sesamum-indicum-l
#7
Hongyan Liu, Mingpu Tan, Haijuan Yu, Liang Li, Fang Zhou, Minmin Yang, Ting Zhou, Yingzhong Zhao
BACKGROUND: Sesame (Sesamum indicum L.) is a globally important oilseed crop with highly-valued oil. Strong hybrid vigor is frequently observed within this crop, which can be exploited by the means of genic male sterility (GMS). We have previously developed a dominant GMS (DGMS) line W1098A that has great potential for the breeding of F1 hybrids. Although it has been genetically and anatomically characterized, the underlying molecular mechanism for male sterility remains unclear and therefore limits the full utilization of such GMS line...
November 10, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27825067/cells-walls-and-endless-forms
#8
REVIEW
Marie Monniaux, Angela Hay
A key question in biology is how the endless diversity of forms found in nature evolved. Understanding the cellular basis of this diversity has been aided by advances in non-model experimental systems, quantitative image analysis tools, and modeling approaches. Recent work in plants highlights the importance of cell wall and cuticle modifications for the emergence of diverse forms and functions. For example, explosive seed dispersal in Cardamine hirsuta depends on the asymmetric localization of lignified cell wall thickenings in the fruit valve...
November 5, 2016: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/27822409/autophagy-inhibition-promotes-epithelial-mesenchymal-transition-through-ros-ho-1-pathway-in-ovarian-cancer-cells
#9
Zhe Zhao, Jing Zhao, Jing Xue, Xinrui Zhao, Peishu Liu
Autophagy has been proved to be involved in metastasis of cancers. However, the detailed mechanisms are still unclear. In this work, we aim to provide the first study of the role that autophagy plays in migration and invasion in ovarian cancer cells. Transwell chamber was used to examine migration and invasion capacities. Western blotting and immunofluorescence were performed to investigate the expressions of mesenchymal markers (Vimentin, N-cadherin), epithelial marker (Keratin), transcript factor (Zeb1) and HO-1...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27816613/tris-1-3-dichloro-2-propyl-phosphate-induced-apoptotic-signaling-pathways-in-sh-sy5y-neuroblastoma-cells
#10
Ruiwen Li, Peijiang Zhou, Yongyong Guo, Jae-Seong Lee, Bingsheng Zhou
Tris (1, 3-dichloro-2-propyl) phosphate (TDCIPP, also known as TDCPP), an extensively used flame retardant, is frequently detected in the environment and biota. Recent studies have shown that TDCIPP has neurotoxic effects. In this study, we determined the mechanisms of TDCIPP-induced neurotoxicity in human neuroblastoma (SH-SY5Y) cells. By using morphological examination, flow cytometry, and mitochondrial membrane potential (ΔYm) measurement, we confirmed that exposure to TDCIPP caused apoptosis accompanied by the activation of apoptosis-related genes (e...
November 2, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27815415/reduction-of-cocaine-induced-locomotor-effects-by-enriched-environment-is-associated-with-cell-specific-accumulation-of-%C3%AE-fosb-in-striatal-and-cortical-subregions
#11
Audrey Lafragette, Michael T Bardo, Virginie Lardeux, Marcello Solinas, Nathalie Thiriet
BACKGROUND: Early exposure to enriched environments (EE) has been shown to decrease the locomotor effects induced by repeated injections of cocaine and to modify basal and cocaine-induced total protein levels of the transcription factor delta-FosB (ΔFosB) in the whole striatum of mice. In this study, we aimed at characterizing whether the profile of ΔFosB accumulation induced by EE and cocaine would be similar or different in terms of brain areas and cell type. METHODS: We used mice expressing the eGFP protein in D1 receptor positive (D1R(+)) neurons to determine whether ΔFosB induced by EE or cocaine injections (5X15mg/kg) would occur in selective sub-populations of neurons in several sub-regions of the striatum and prefrontal cortex...
November 4, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27810268/identification-and-characterization-of-micrornas-in-maize-endosperm-response-to-exogenous-sucrose-using-small-rna-sequencing
#12
Huanhuan Huang, Jiao Long, Lanjie Zheng, Yangping Li, Yufeng Hu, Guowu Yu, Hanmei Liu, Yinghong Liu, Zhi Huang, Junjie Zhang, Yubi Huang
Sucrose acts as a signaling molecule for genes critical to starch biosynthesis in maize endosperm. Previously, we showed that sucrose could regulate starch biosynthesis in maize via transcription factors. To better understand the complex regulation of starch biosynthesis, the 10days after pollination endosperm from Zea mays L. B73 inbred line was collected and treated with sucrose for small RNA sequencing. The sequencing results revealed that 24 known miRNAs and 190 novel miRNAs were significantly differentially expressed in response to sucrose...
November 1, 2016: Genomics
https://www.readbyqxmd.com/read/27794261/differentiation-of-conductive-cells-a-matter-of-life-and-death
#13
REVIEW
Jung-Ok Heo, Bernhard Blob, Ykä Helariutta
Two major conducting tissues in plants, phloem and xylem, are composed of highly specialized cell types adapted to long distance transport. Sieve elements (SEs) in the phloem display a thick cell wall, callose-rich sieve plates and low cytoplasmic density. SE differentiation is driven by selective autolysis combined with enucleation, after which the plasma membrane and some organelles are retained. By contrast, differentiation of xylem tracheary elements (TEs) involves complete clearance of the cellular components by programmed cell death followed by autolysis of the protoplast; this is accompanied by extensive deposition of lignin and cellulose in the cell wall...
October 26, 2016: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/27790239/the-arabidopsis-transcription-factor-anac032-represses-anthocyanin-biosynthesis-in-response-to-high-sucrose-and-oxidative-and-abiotic-stresses
#14
Kashif Mahmood, Zhenhua Xu, Ashraf El-Kereamy, José A Casaretto, Steven J Rothstein
Production of anthocyanins is one of the adaptive responses employed by plants during stress conditions. During stress, anthocyanin biosynthesis is mainly regulated at the transcriptional level via a complex interplay between activators and repressors of anthocyanin biosynthesis genes. In this study, we investigated the role of a NAC transcription factor, ANAC032, in the regulation of anthocyanin biosynthesis during stress conditions. ANAC032 expression was found to be induced by exogenous sucrose as well as high light (HL) stress...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27780204/the-sweet-potato-nac-domain-transcription-factor-ibnac1-is-dynamically-coordinated-by-the-activator-ibbhlh3-and-the-repressor-ibbhlh4-to-reprogram-the-defense-mechanism-against-wounding
#15
Shi-Peng Chen, Chih-Hsien Kuo, Hsueh-Han Lu, Hui-Shan Lo, Kai-Wun Yeh
IbNAC1 is known to activate the defense system by reprogramming a genetic network against herbivory in sweet potato. This regulatory activity elevates plant defense potential but relatively weakens plants by IbNAC1-mediated JA response. The mechanism controlling IbNAC1 expression to balance plant vitality and survival remains unclear. In this study, a wound-responsive G-box cis-element in the IbNAC1 promoter from -1484 to -1479 bp was identified. From a screen of wound-activated transcriptomic data, one transcriptional activator, IbbHLH3, and one repressor, IbbHLH4, were selected that bind to and activate or repress, respectively, the G-box motif in the IbNAC1 promoter to modulate the IbNAC1-mediated response...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27770200/arabidopsis-atnap-functions-as-a-negative-regulator-via-repression-of-areb1-in-salt-stress-response
#16
Hye-Yeon Seok, Dong-Hyuk Woo, Linh Vu Nguyen, Huong T Tran, Vaishali N Tarte, Syed Muhammad Muntazir Mehdi, Sun-Young Lee, Yong-Hwan Moon
AtNAP , an Arabidopsis NAC transcription factor family gene, functions as a negative regulator via transcriptional repression of AREB1 in salt stress response. AtNAP is an NAC family transcription factor in Arabidopsis and is known to be a positive regulator of senescence. However, its exact function and underlying molecular mechanism in stress responses are not well known. Here, we investigated functional roles of AtNAP in salt stress response. AtNAP expression significantly increased at the seedling stage, with higher expression in both shoots and roots under NaCl, mannitol, and ABA treatments...
October 21, 2016: Planta
https://www.readbyqxmd.com/read/27759025/corrigendum-the-nac-transcription-factor-anac046-is-a-positive-regulator-of-chlorophyll-degradation-and-senescence-in-arabidopsis-leaves
#17
Chihiro Oda-Yamamizo, Nobutaka Mitsuda, Shingo Sakamoto, Daisuke Ogawa, Masaru Ohme-Takagi, Akemi Ohmiya
No abstract text is available yet for this article.
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27738714/transcription-factors-involved-in-drought-tolerance-and-their-possible-role-in-developing-drought-tolerant-cultivars-with-emphasis-on-wheat-triticum-aestivum-l
#18
Vijay Gahlaut, Vandana Jaiswal, Anuj Kumar, Pushpendra Kumar Gupta
TFs involved in drought tolerance in plants may be utilized in future for developing drought tolerant cultivars of wheat and some other crops. Plants have developed a fairly complex stress response system to deal with drought and other abiotic stresses. These response systems often make use of transcription factors (TFs); a gene encoding a specific TF together with -its target genes constitute a regulon, and take part in signal transduction to activate/silence genes involved in response to drought. Since, five specific families of TFs (out of >80 known families of TFs) have gained widespread attention on account of their significant role in drought tolerance in plants, TFs and regulons belonging to these five multi-gene families (AP2/EREBP, bZIP, MYB/MYC, NAC and WRKY) have been described and their role in improving drought tolerance discussed in this brief review...
October 13, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27725188/omeprazole-induces-heme-oxygenase-1-in-fetal-human-pulmonary-microvascular-endothelial-cells-via-hydrogen-peroxide-independent-nrf2-signaling-pathway
#19
Ananddeep Patel, Shaojie Zhang, Amrit Kumar Shrestha, Paramahamsa Maturu, Bhagavatula Moorthy, Binoy Shivanna
Omeprazole (OM) is an aryl hydrocarbon receptor (AhR) agonist and a proton pump inhibitor that is used to treat humans with gastric acid related disorders. Recently, we showed that OM induces NAD (P) H quinone oxidoreductase-1 (NQO1) via nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent mechanism. Heme oxygenase-1 (HO-1) is another cytoprotective and antioxidant enzyme that is regulated by Nrf2. Whether OM induces HO-1 in fetal human pulmonary microvascular endothelial cells (HPMEC) is unknown. Therefore, we tested the hypothesis that OM will induce HO-1 expression via Nrf2 in HPMEC...
November 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27699938/kappa-opioid-antagonists-for-psychiatric-disorders-from-bench-to-clinical-trials
#20
William A Carlezon, Andrew D Krystal
Kappa-opioid receptor (KOR) antagonists are currently being considered for the treatment of a variety of neuropsychiatric conditions, including depressive, anxiety, and substance abuse disorders. A general ability to mitigate the effects of stress, which can trigger or exacerbate these conditions, may explain their putative efficacy across such a broad array of conditions. The discovery of their potentially therapeutic effects evolved from preclinical research designed to characterize the molecular mechanisms by which experience causes neuroadaptations in the nucleus accumbens (NAc), a key element of brain reward circuitry...
October 2016: Depression and Anxiety
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