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https://www.readbyqxmd.com/read/29784845/interaction-of-bacterial-phenazines-with-colistimethate-in-bronchial-epithelial-cells
#1
Valeri V Mossine, Deborah L Chance, James K Waters, Thomas P Mawhinney
Multidrug-resistant bacterial infections are being increasingly treated in clinics with polymyxins, a class of antibiotics associated with adverse effects in the kidney, nervous system, or airways of a significant proportion of human and animal patients. Although many of the resistant pathogens display enhanced virulence, a hazard of cytotoxic interactions between polymyxin antibiotics and bacterial virulence factors (VFs) has not been assessed, to date. We report here on testing paired combinations of four Pseudomonas aeruginosa VF phenazine toxins, pyocyanin (PYO), 1-hydroxyphenazine (1-HP), phenazine-1-carboxylic acid (PCA), phenazine-1-carboxamide (PCN), and two commonly prescribed polymyxin drugs, colistimethate (CMS)/colistin and polymyxin B, in three human airway cell lines, BEAS-2B, HBE-1, and CFT-1...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29774039/a-membrane-bound-nac-like-transcription-factor-osntl5-represses-the-flowering-in-oryza-sativa
#2
Siyi Guo, Shaojun Dai, Prashant K Singh, Hongyan Wang, Yanan Wang, Jeanie L H Tan, Wanyi Wee, Toshiro Ito
In spite of short-day (SD) nature, rice ( Oryza sativa ) shares a conserved photoperiodic network for flowering control with long-day plants like Arabidopsis thaliana. Flowering or heading is an important agronomic trait in rice. NAC transcription factors (TFs) are well-conserved and one of the largest families of plant TFs. However, their function in flowering or heading time is not well-known yet. A preferential expression of a membrane-bound NAC-like TF OsNTL5 in developing leaves and panicles of rice indicated to us its putative role in flowering...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29762546/transcriptome-analysis-in-chinese-cabbage-brassica-rapa-ssp-pekinensis-provides-the-role-of-glucosinolate-metabolism-in-response-to-drought-stress
#3
Seung Hee Eom, Seung-A Baek, Jae Kwang Kim, Tae Kyung Hyun
Although drought stress is one of the most limiting factors in growth and production of Chinese cabbage ( Brassica rapa L. ssp. pekinensis), the underlying biochemical and molecular causes are poorly understood. In the present study, to address the mechanisms underlying the drought responses, we analyzed the transcriptome profile of Chinese cabbage grown under drought conditions. Drought stress transcriptionally activated several transcription factor genes, including AP2 / ERFs , bHLHs , NACs and bZIPs , and was found to possibly result in transcriptional variation in genes involved in organic substance metabolic processes...
May 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29760199/the-nac-transcription-factor-slnap2-regulates-leaf-senescence-and-fruit-yield-in-tomato
#4
Xuemin Ma, Youjun Zhang, Veronika Turečková, Gang-Ping Xue, Alisdair R Fernie, Bernd Mueller-Roeber, Salma Balazadeh
Leaf senescence is an essential physiological process in plants that supports the recycling of nitrogen and other nutrients to support the growth of developing organs, including young leaves, seeds and fruits. Thus, the regulation of senescence is crucial for evolutionary success in wild populations and for increasing yield in crops. Here we describe the influence of a NAC transcription factor, SlNAP2 (Solanum lycopersicum NAC-like, activated by apetala3/pistillata), that controls both leaf senescence and fruit yield in tomato (Solanum lycopersicum)...
May 14, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29752433/palmitic-acid-but-not-high-glucose-induced-myocardial-apoptosis-is-alleviated-by-n%C3%A2-acetylcysteine-due-to-attenuated-mitochondrial-derived-ros-accumulation-induced-endoplasmic-reticulum-stress
#5
Yang He, Lingyun Zhou, Zhiqiang Fan, Shikun Liu, Weijin Fang
Pharmacological inhibition of reactive oxygen species (ROS) is a potential strategy to prevent diabetes-induced cardiac dysfunction. This study was designed to investigate precise effects of antioxidant N‑acetylcysteine (NAC) in alleviating diabetic cardiomyopathy (DCM). Echocardiography and histologic studies were performed 12 weeks after streptozocin injection. Protein levels involved in endoplasmic reticulum stress (ERS) and apoptosis were analyzed by western blotting in diabetic hearts or high-glucose (HG, 30 mM)- and palmitic acid (PA, 300 μM)-cultured neonatal rat cardiomyocytes (NRCMs)...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29750935/altered-regulation-of-nur77-nuclear-receptor-gene-expression-in-the-mesocorticolimbic-regions-of-rat-brain-by-amphetamine-sensitization
#6
Sanjeev K Bhardwaj, Fatéma Dodat, Daniel Lévesque, Lalit K Srivastava
The mechanisms underlying psychostimulant drug-induced sensitization include long-term cellular and molecular adaptations in dopaminergic circuits. Nur77, a member of the Nur family of transcription factors, is expressed in brain regions receiving dopamine inputs and plays a role in activity-induced synaptic modification. Here we evaluated changes in Nur77 mRNA levels in the medial prefrontal cortex (mPFC), dorsal striatum (Str) and nucleus accumbens (NAc) of rats receiving a repeated, sensitizing regimen of amphetamine (AMPH)...
May 8, 2018: Brain Research
https://www.readbyqxmd.com/read/29740511/candidate-genes-associated-with-red-colour-formation-revealed-by-comparative-genomic-variant-analysis-of-red-and-green-skinned-fruits-of-japanese-apricot-prunus-mume
#7
Xiaopeng Ni, Song Xue, Shahid Iqbal, Wanxu Wang, Zhaojun Ni, Muhammad Khalil-Ur-Rehman, Zhihong Gao
The red-skinned fruit of Japanese apricot ( Prunus mume Sieb. et Zucc) appeals to customers due to its eye-catching pigmentation, while the mechanism related to its colour formation is still unclear. In this study, genome re-sequencing of six Japanese apricot cultivars was carried out with approximately 92.2 Gb of clean bases using next-generation sequencing. A total of 32,004 unigenes were assembled with an average of 83.1% coverage rate relative to reference genome. A wide range of genetic variation was detected, including 7,387,057 single nucleotide polymorphisms, 456,222 insertions or deletions and 129,061 structural variations in all genomes...
2018: PeerJ
https://www.readbyqxmd.com/read/29739710/crispr-cas9-mediated-mutagenesis-of-the-ephemeral1-locus-that-regulates-petal-senescence-in-japanese-morning-glory
#8
Kenichi Shibuya, Kenta Watanabe, Michiyuki Ono
Flower longevity is one of the most important traits in ornamental plants. In Japanese morning glory (Ipomoea nil), EPHEMERAL1 (EPH1), a NAC transcription factor, is reportedly a key regulator of petal senescence. CRISPR/Cas9-mediated targeted mutagenesis is a powerful tool for crop breeding as well as for biological research. Here we report the application of CRISPR/Cas9 technology to targeted mutagenesis of the EPH1 gene in I. nil. Three regions within the EPH1 gene were simultaneously targeted by a single binary vector containing three single-guide RNA cassettes...
April 27, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29735710/time-evolving-genetic-networks-reveal-a-nac-troika-that-negatively-regulates-leaf-senescence-in-arabidopsis
#9
Hyo Jung Kim, Ji-Hwan Park, Jingil Kim, Jung Ju Kim, Sunghyun Hong, Jeongsik Kim, Jin Hee Kim, Hye Ryun Woo, Changbong Hyeon, Pyung Ok Lim, Hong Gil Nam, Daehee Hwang
Senescence is controlled by time-evolving networks that describe the temporal transition of interactions among senescence regulators. Here, we present time-evolving networks for NAM/ATAF/CUC (NAC) transcription factors in Arabidopsis during leaf aging. The most evident characteristic of these time-dependent networks was a shift from positive to negative regulation among NACs at a presenescent stage. ANAC017, ANAC082, and ANAC090, referred to as a "NAC troika," govern the positive-to-negative regulatory shift...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29723301/genome-wide-analysis-of-the-nac-transcription-factor-family-and-their-expression-during-the-development-and-ripening-of-the-fragaria-%C3%A3-ananassa-fruits
#10
Enriqueta Moyano, Félix J Martínez-Rivas, Rosario Blanco-Portales, Francisco Javier Molina-Hidalgo, Pablo Ric-Varas, Antonio J Matas-Arroyo, José Luis Caballero, Juan Muñoz-Blanco, Antonio Rodríguez-Franco
NAC proteins are a family of transcription factors which have a variety of important regulatory roles in plants. They present a very well conserved group of NAC subdomains in the N-terminal region and a highly variable domain at the C-terminus. Currently, knowledge concerning NAC family in the strawberry plant remains very limited. In this work, we analyzed the NAC family of Fragaria vesca, and a total of 112 NAC proteins were identified after we curated the annotations from the version 4.0.a1 genome. They were placed into the ligation groups (pseudo-chromosomes) and described its physicochemical and genetic features...
2018: PloS One
https://www.readbyqxmd.com/read/29702625/overexpression-of-a-novel-apple-nac-transcription-factor-gene-mdnac1-confers-the-dwarf-phenotype-in-transgenic-apple-malus-domestica
#11
Dongfeng Jia, Xiaoqing Gong, Mingjun Li, Chao Li, Tingting Sun, Fengwang Ma
Plant height is an important trait for fruit trees. The dwarf characteristic is commonly associated with highly efficient fruit production, a major objective when breeding for apple ( Malus domestica ). We studied the function of MdNAC1 , a novel NAC transcription factor (TF) gene in apple related to plant dwarfing. Localized primarily to the nucleus, MdNAC1 has transcriptional activity in yeast cells. Overexpression of the gene results in a dwarf phenotype in transgenic apple plants. Their reduction in size is manifested by shorter, thinner stems and roots, and a smaller leaf area...
April 27, 2018: Genes
https://www.readbyqxmd.com/read/29686303/mitochondrial-dna-induces-foley-catheter-related-bladder-inflammation-via-toll-like-receptor-9-activation
#12
Carlos A Puyo, Alexander Earhart, Nicholas Staten, Yuan Huang, Alana Desai, Henry Lai, Ramakrishna Venkatesh
Bladder instrumentation engages the innate immune system via neutrophil activation, promoting inflammation and pain. Elevated levels of mitochondrial DNA (mtDNA) have been associated with tissue damage and organ dysfunction. We hypothesized that local bladder trauma induced by a Foley catheter (FC) will result in mtDNA release, migration of neutrophils into the bladder lumen, and activation of the Toll-like receptor 9 (TLR9) and nuclear factor kappa B (NF-κB) pathway leading to bladder tissue damage. We randomized 10 swine into two groups receiving uncoated, or chloroquine/N-Acetylcysteine (CQ/NAC)-coated FCs...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29681752/molecular-aspects-of-flower-senescence-and-strategies-to-improve-flower-longevity
#13
REVIEW
Kenichi Shibuya
Flower longevity is one of the most important traits for ornamental plants. Ethylene plays a crucial role in flower senescence in some plant species. In several species that show ethylene-dependent flower senescence, genetic modification targeting genes for ethylene biosynthesis or signaling has improved flower longevity. Although little is known about regulatory mechanisms of petal senescence in flowers that show ethylene-independent senescence, a recent study of Japanese morning glory revealed that a NAC transcription factor, EPHEMERAL1 (EPH1), is a key regulator in ethylene-independent petal senescence...
January 2018: Breeding Science
https://www.readbyqxmd.com/read/29672568/rna-seq-transcriptome-analysis-of-amaranthus-palmeri-with-differential-tolerance-to-glufosinate-herbicide
#14
Reiofeli A Salas-Perez, Christopher A Saski, Rooksana E Noorai, Subodh K Srivastava, Amy L Lawton-Rauh, Robert L Nichols, Nilda Roma-Burgos
Amaranthus palmeri (Amaranthaceae) is a noxious weed in several agroecosystems and in some cases seriously threatens the sustainability of crop production in North America. Glyphosate-resistant Amaranthus species are widespread, prompting the use of alternatives to glyphosate such as glufosinate, in conjunction with glufosinate-resistant crop cultivars, to help control glyphosate-resistant weeds. An experiment was conducted to analyze the transcriptome of A. palmeri plants that survived exposure to 0.55 kg ha-1 glufosinate...
2018: PloS One
https://www.readbyqxmd.com/read/29671785/activation-of-er-stress-dependent-mir-216b-has-a-critical-role-in-salvia-miltiorrhiza-ethanol-extract-induced-apoptosis-in-u266-and-u937-cells
#15
Changmin Kim, Hyo-Sook Song, Hojung Park, Bonglee Kim
Although Salvia miltiorrhiza has been reported to have anti-cancer mechanisms, such as caspase activation, cell cycle arrest, an anti-angiogenesis effect, and Bcl-2 family regulation, its underlying mechanism of endoplasmic reticulum (ER) stress-mediated apoptosis has never been demonstrated. Thus, in this current study, ER stress-related apoptosis via miR-216b of the ethanol extract of Salvia miltiorrhiza (SM) is elucidated for the first time. SM treatment inhibited the viability of U266 and U937 cells in a concentration-dependent manner...
April 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29670103/histone-h2ax-deficiency-causes-neurobehavioral-deficits-and-impaired-redox-homeostasis
#16
Urbain Weyemi, Bindu D Paul, Adele M Snowman, Parthav Jailwala, Andre Nussenzweig, William M Bonner, Solomon H Snyder
ATM drives DNA repair by phosphorylating the histone variant H2AX. While ATM mutations elicit prominent neurobehavioral phenotypes, neural roles for H2AX have been elusive. We report impaired motor learning and balance in H2AX-deficient mice. Mitigation of reactive oxygen species (ROS) with N-acetylcysteine (NAC) reverses the behavioral deficits. Mouse embryonic fibroblasts deficient for H2AX exhibit increased ROS production and failure to activate the antioxidant response pathway controlled by the transcription factor NRF2...
April 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29659022/transcription-factor-rd26-is-a-key-regulator-of-metabolic-reprogramming-during-dark-induced-senescence
#17
Iman Kamranfar, Gang-Ping Xue, Takayuki Tohge, Mastoureh Sedaghatmehr, Alisdair R Fernie, Salma Balazadeh, Bernd Mueller-Roeber
Leaf senescence is a key process in plants that culminates in the degradation of cellular constituents and massive reprogramming of metabolism for the recovery of nutrients from aged leaves for their reuse in newly developing sinks. We used molecular-biological and metabolomics approaches to identify NAC transcription factor (TF) RD26 as an important regulator of metabolic reprogramming in Arabidopsis thaliana. RD26 directly activates CHLOROPLAST VESICULATION (CV), encoding a protein crucial for chloroplast protein degradation, concomitant with an enhanced protein loss in RD26 overexpressors during senescence, but a reduced decline of protein in rd26 knockout mutants...
April 16, 2018: New Phytologist
https://www.readbyqxmd.com/read/29656008/identification-of-mirnas-linked-with-the-drought-response-of-tef-eragrostis-tef-zucc-trotter
#18
Federico Martinelli, Gina Cannarozzi, Bipin Balan, Fredy Siegrist, Annett Weichert, Regula Blösch, Zerihun Tadele
Tef [Eragrostis tef (Zucc.) Trotter], a staple food crop in the Horn of Africa and particularly in Ethiopia, has several beneficial agronomical and nutritional properties, including waterlogging and drought tolerance. In this study, we performed microRNA profiling of tef using the Illumina HiSeq 2500 platform, analyzing both shoots and roots of two tef genotypes, one drought-tolerant (Tsedey) and one drought-susceptible (Alba). We obtained more than 10 million filtered reads for each of the 24 sequenced small cDNA libraries...
March 29, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29651294/lateral-root-development-in-potato-is-mediated-by-stu-mi164-regulation-of-nac-transcription-factor
#19
Li Zhang, Lei Yao, Ning Zhang, Jiangwei Yang, Xi Zhu, Xun Tang, Alejandro Calderón-Urrea, Huaijun Si
The NAC designation is derived from petunia ( Petunia hybrida ) gene NO APICAL MERISTEM ( NAM ) and Arabidopsis genes ATAF1/ATAF2 and CUP-SHAPED COTYLEDON2 ( CUC2 ), which belongs to the family of plant-specific transcription factors (TFs), and plays important role in plant development processes, such as response to biotic and abiotic stress, and hormone signaling. MicroRNAs (miRNAs) are a class of small, non-coding endogenous RNAs which play versatile and significant role in plant stress response and development via negatively affecting gene expression at a post-transcriptional level...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29650161/molecular-and-functional-characterization-of-shnac1-an-nac-transcription-factor-from-solanum-habrochaites
#20
Hui Liu, Yuhong Zhou, Hanxia Li, Taotao Wang, Junhong Zhang, Bo Ouyang, Zhibiao Ye
NAC transcription factors (TFs) are important regulators of plant adaptation to abiotic stress. In this study, we functionally characterized an NAC TF, ShNAC1, from Solanum habrochaites. ShNAC1 was up-regulated by drought, cold, and salt stresses, and it displayed lower expression at the late stage of stress treatments than its orthologous gene in S. lycopersicum. Overexpression of ShNAC1 in tomato resulted in reduced cold, drought, and salt tolerance. Additionally, ShNAC1 displayed the highest expression in senescent leaf, and overexpressing ShNAC1 accelerated salt- and dark-induced leaf senescence...
June 2018: Plant Science: An International Journal of Experimental Plant Biology
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