Christopher Redmond, Moses M Kitakule, Aran Son, McKella Sylvester, Keith Sacco, Ottavia Delmonte, Francesco Licciardi, Riccardo Castagnoli, Cecilia Poli, Yasmin Espinoza, Camila Astudillo, Sarah E Weber, Gina A Montealegre Sanchez, Karyl Barron, Mary Magliocco, Kerry Dobbs, Yu Zhang, Helen Matthews, Cihan Oguz, Helen C Su, Luigi D Notarangelo, Pamela A Frischmeyer-Guerrerio, Daniella M Schwartz
Multisystem Inflammatory Syndrome in Children (MIS-C) is a systemic inflammatory condition that follows SARS-CoV2 infection or exposure in children. Clinical presentations are highly variable and include fever, gastrointestinal (GI) disease, shock, and Kawasaki Disease-like illness (MIS-C/KD). Compared to patients with acute COVID, patients with MIS-C have a distinct immune signature and expansion of TRVB11 expressing T cells. However, the relationship between immunological and clinical phenotypes of MIS-C is unknown...
September 2, 2022: medRxiv