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clinical profile of children with shock

Reem Masarwa, Gideon Paret, Amichai Perlman, Shimon Reif, Bruria Hirsh Raccah, Ilan Matok
BACKGROUND: Vasopressin (AVP) and terlipressin (TP) have been used as last-line therapy in refractory shock in children. However, the efficacy and safety profiles of AVP and TP have not been determined in pediatric refractory shock of different origins. We aimed to assess the efficacy and safety of the addition of AVP/TP therapy in pediatric refractory shock of all causes compared to conventional therapy with fluid resuscitation and vasopressor and inotropic therapy. METHODS: We conducted a systematic review, meta-analysis, and trial sequential analysis (TSA) comparing AVP and TP to conventional therapy...
January 5, 2017: Critical Care: the Official Journal of the Critical Care Forum
Miguel Ángel Martínez-Medina, Adela Rascón-Alcantar
BACKGROUND: Rocky Mountain spotted fever is a life threatening disease caused by Rickettsia rickettsia, characterized by multisystem involvement. METHODS: We studied 19 dead children with Rocky Mountain spotted fever. All children who were suspected of having rickettsial infections were defined as having Rocky Mountain spotted fever by serology test and clinical features. Through the analysis of each case, we identified the clinical profile and complications associated to the death of a patient...
November 2016: Gaceta Médica de México
Sriram Pothapregada, Banupriya Kamalakannan, Mahalaskhmy Thulasingham, Srinivasan Sampath
OBJECTIVE: To study the clinical profile and outcome of dengue fever in children at a tertiary care hospital in Puducherry. MATERIALS AND METHODS: All children (0-12 years of age) diagnosed and confirmed as dengue fever from August 2012 to January 2015 were reviewed retrospectively from hospital case records as per the revised World Health Organization guidelines for dengue fever. The diagnosis was confirmed by NS1 antigen-based ELISA test or dengue serology for IgM and IgG antibodies, and the data were analyzed using SPSS 16...
July 2016: Journal of Global Infectious Diseases
B S Kalal, P Puranik, S Nagaraj, S Rego, A Shet
BACKGROUND: Rickettsial infections are re-emerging. In India, they are now being reported from several areas where they were previously unknown. OBJECTIVES: The objective of this study was to describe the epidemiology, clinical profile and outcome of serologically-confirmed scrub typhus and spotted fever among children in a tertiary care hospital in Bengaluru. MATERIALS AND METHODS: Hospitalised children aged <18 years, with clinical features suggestive of rickettsial disease admitted between January 2010 and October 2012 were included prospectively...
July 2016: Indian Journal of Medical Microbiology
Dinesh Kumar Narayanasamy, Arul Kumaran Arunagirinathan, Revathi Krishna Kumar, V D Raghavendran
OBJECTIVE: To study the clinical and laboratory profile of pediatric scrub typhus in rural south India. METHODS: This is a descriptive study of the clinical and laboratory features of 117 children with IgM ELISA proven scrub typhus out of 448 children, who were admitted in the Pediatric ward of a tertiary care hospital, during the study period of November 2014 through March 2015. RESULTS: Fever was present in all 117 children, with mean duration of fever at admission as 9 d...
November 2016: Indian Journal of Pediatrics
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Renu Suthar, Naveen Sankhyan, Jitendra K Sahu, Niranjan K Khandelwal, Sunit Singhi, Pratibha Singhi
BACKGROUND: Acute transvers myelitis (ATM) is a rare and disabling condition in childhood. There are only few reports of clinical profile, prognosis and predictors of ATM from developing countries. OBJECTIVE: To study the clinical profile of children with ATM and predictors of its outcome. METHOD: Retrospective analysis of children <12 years of age diagnosed with ATM over a period of 6 years from a tertiary care institute. RESULTS: Thirty six children (21 boys, median age-7...
May 2016: European Journal of Paediatric Neurology: EJPN
S Trivedi, A Al-Nofal, S Kumar, S Tripathi, R J Kahoud, P J Tebben
INTRODUCTION: Zoledronic acid is an intravenous bisphosphonate used to increase bone mineral density and reduce the risk of fractures. Its safety profile compares well with pamidronate in pediatric patients. We describe an acute, severe, life-threatening, inflammatory reaction in a child. METHODS: A 7-year-old boy with complex medical problems and chronic ventilator requirements was admitted to the pediatric intensive care unit (due to ventilator needs) for zoledronic acid infusion and subsequent monitoring...
July 2016: Osteoporosis International
Sriram Pothapregada, Banupriya Kamalakannan, Mahalakshmy Thulasingam
OBJECTIVES: To study the clinical profile and outcome of the atypical manifestations of dengue fever in children. METHODS: All children (0-12 y of age) diagnosed and confirmed as dengue fever at a tertiary care hospital at Puducherry, between the 1st of August 2012 and January 31st 2015 were reviewed retrospectively from hospital case records as per the revised World Health Organization (WHO) guidelines 2011 for dengue fever. The diagnosis was confirmed by NS1 antigen-based ELISA test or dengue serology for IgM and IgG antibodies and the data was analyzed using SPSS 16...
June 2016: Indian Journal of Pediatrics
Harshavardhini Palanivel, Shashikala Nair, Anandhalakshmi Subramaniyan, Philip Vivian Joseph Ratnam, Reba Kanungo
BACKGROUND: Outbreaks of dengue infection occur in several parts of India with clockwork precision closely related to changing seasons. Most recent outbreak in Puducherry occurred between October 2012 and January 2013, affected a sizable pediatric population. A prospective study was done to characterize the demographic, diagnostic and clinical profile of pediatric patients in a tertiary care center in Puducherry. MATERIALS AND METHODS: Data of patients serologically positive for either dengue NS1 antigen or anti-dengue IgM antibodies were analyzed...
July 2015: Indian Journal of Pathology & Microbiology
Nowneet Kumar Bhat, Minakshi Dhar, Garima Mittal, Nadia Shirazi, Anil Rawat, Bram Prakash Kalra, Vipan Chandar, Sohaib Ahmad
OBJECTIVE: To study the clinical profile and complications of childhood scrub typhus. METHODS: Prospective observational study of 66 children with scrub typhus, admitted to a tertiary hospital in north India, during the period between January 2011 and December 2012. The diagnosis was confirmed by serology. Findings : All children presented with fever. Other common symptoms were vomiting (56%), facial swelling (52%), cough (35%), abdominal pain (33%), breathlessness (29%) and decreased urine output (29%)...
August 2014: Iranian Journal of Pediatrics
Alejandra Vomero, Gabriela García, Soledad Pandolfo, Carlos Zunino, María Ambrosoni, Gabriela Algorta, M Catalina Pírez
INTRODUCTION: Streptococcus pyogenes infection causes a wide spectrum of clinical manifestations. Invasive disease (ID) is defined by the isolation of the microorganism from sterile sites. OBJECTIVE: To analyze the clinical, epidemiological and molecular characteristics of ID by S.pyogenes in children hospitalized at Pediatric Hospital Pereira Rossell, from January 2005 to January 2013. MATERIALS AND METHODS: A descriptive retrospective study was done in cases with isolation of S...
December 2014: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Helena Cornella, Clara Alsinet, Sergi Sayols, Zhongyang Zhang, Ke Hao, Laia Cabellos, Yujin Hoshida, Augusto Villanueva, Swan Thung, Stephen C Ward, Leonardo Rodriguez-Carunchio, Maria Vila-Casadesús, Sandrine Imbeaud, Anja Lachenmayer, Alberto Quaglia, David M Nagorney, Beatriz Minguez, Flair Carrilho, Lewis R Roberts, Samuel Waxman, Vincenzo Mazzaferro, Myron Schwartz, Manel Esteller, Nigel D Heaton, Jessica Zucman-Rossi, Josep M Llovet
BACKGROUND & AIMS: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer that develops in children and young adults without cirrhosis. Little is known about its pathogenesis, and it can be treated only with surgery. We performed an integrative genomic analysis of a large series of patients with FLC to identify associated genetic factors. METHODS: By using 78 clinically annotated FLC samples, we performed whole-transcriptome (n = 58), single-nucleotide polymorphism array (n = 41), and next-generation sequencing (n = 48) analyses; we also assessed the prevalence of the DNAJB1-PRKACA fusion transcript associated with this cancer (n = 73)...
April 2015: Gastroenterology
Sheetal Ganjoo, Kaisar Ahmad, Umar Amin Qureshi, Zahed Hussain Mir
OBJECTIVE: To assess the clinical and demographic profile of Systemic Inflammatory Response Syndrome (SIRS) and sepsis, among newly admitted children in different age groups in a hospital in North India. METHODS: This prospective study was conducted at a referral care centre in Northern India. All children, age group 0 to <18 y, admitted on days selected for study were screened and those with abnormal temperature and abnormal leukocyte count were included for further assessment...
August 2015: Indian Journal of Pediatrics
Loic Raffray, Marie-Catherine Receveur, Mathilde Beguet, Pierre Lauroua, Thierry Pistone, Denis Malvy
BACKGROUND: Parenteral artesunate is recommended as first-line therapy for severe and complicated malaria. Although its efficacy has been proven, long-term safety profile is still under evaluation. Several cases of delayed haemolytic anaemia occurred after initial clinical improvement and resolution of parasitaemia in non-immune travellers and children living in endemic areas. Reports have generated concern that this phenomenon might be related to the treatment itself, either by direct toxicity or immune-related mechanism...
2014: Malaria Journal
Enrique Chacon-Cruz, Luz Elena Espinosa-De Los Monteros, Samuel Navarro-Alvarez, Jose Luis Aranda-Lozano, Maria Luisa Volker-Soberanes, Rosa Maria Rivas-Landeros, Ariadna Annete Alvelais-Arzamendi, Julio Alberto Vazquez
BACKGROUND: Invasive meningococcal disease (IMD) has been reported to be endemic in children from Tijuana, Mexico and the risk of an outbreak was always a threat. OBJECTIVES: To describe all clinical, epidemiological and microbiological features of a meningococcal outbreak that occurred in Tijuana, Mexico. METHODS: All cases with IMD were admitted at different emergency departments within the city and diagnosed by culture and agglutination tests...
May 2014: Therapeutic Advances in Vaccines
Surangrat Pongpan, Apichart Wisitwong, Chamaiporn Tawichasri, Jayanton Patumanond, Sirianong Namwongprom
Objectives. To develop a simple scoring system to predict dengue infection severity based on patient characteristics and routine clinical profiles. Methods. Retrospective data of children with dengue infection from 3 general hospitals in Thailand were reviewed. Dengue infection was categorized into 3 severity levels: dengue infection (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Coefficients of significant predictors of disease severity under ordinal regression analysis were transformed into item scores...
2013: ISRN Pediatrics
Ragini Singh, Shruti Kumar, S K Rana, Brijesh Thakur, S P Singh
BACKGROUND: Falciparum malaria has been constantly associated with high morbidity and mortality for a long time. Vivax malaria, which was once thought to be a relatively benign condition, is appearing in its more malignant form, with severity gradually becoming a serious concern. AIM: This study is aimed to find out and compare the clinical and pathological manifestations of vivax and falciparum malaria in pediatric age group in Uttarakhand. SETTING AND DESIGN: A prospective study was carried out at a tertiary care hospital of a medical college in Uttarakhand, India...
October 2013: Journal of Clinical and Diagnostic Research: JCDR
G S Shah, S Islam, B K Das
The present work is a prospective, observational, hospital based study on 100 sero positive cases of dengue infection, admitted to Dhaka Children Hospital, Dhaka, Bangladesh during the period 2000 -2001. The patients were in the age group 8 months to 14 years with a mean age of 8.3 years. The serological tests were performed by rapid strip test. Primary dengue infection (only Ig M positive) was observed in 15% cases while rest 85% were secondary dengue infection (either Ig G or both Ig M and Ig G positive)...
January 2006: Kathmandu University Medical Journal (KUMJ)
C E Price, S Cox, H Rode
BACKGROUND: Peri-anal burns are common in children. Continual exposure to enteric organisms may lead to a contaminated burn wound, invasive sepsis, graft loss, scar contracture, anal and urinary malfunction, and delayed discharge from hospital. Use of a temporary diverting colostomy has been advocated to reduce complications. OBJECTIVES: To review the incidence, indications, methods, bacteriology, therapeutic effects and outcomes of colostomy for perianal burns...
August 2013: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
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