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https://www.readbyqxmd.com/read/29471439/robot-assisted-ligation-of-bronchial-artery-could-be-an-alternative-to-embolization
#1
Bruno Pochulu, Omar Sarsam, Christophe Peillon, Jean-Marc Baste
A 37-year-old patient presented with a self-limiting episode of moderate haemoptysis. Contrast-enhanced chest computed tomography showed a tortuous and dilated right bronchial artery arising from the descending aorta at the level of T6. Therapeutic angiography was attempted, but in the presence of spinal artery arising from the bronchial artery in question, selective embolization was contraindicated due to risk of spinal cord ischaemia. After a multidisciplinary meeting, it was decided to attempt surgery to ligate this pathological artery...
March 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29471419/true-lumen-and-false-lumen-diameter-changes-in-the-downstream-aorta-after-frozen-elephant-trunk-implantation
#2
Tim Berger, Maximilian Kreibich, Julia Morlock, Stoyan Kondov, Johannes Scheumann, Fabian A Kari, Bartosz Rylski, Matthias Siepe, Friedhelm Beyersdorf, Martin Czerny
OBJECTIVES: To evaluate early and mid-term clinical outcomes and to assess the potential of the frozen elephant trunk technique to induce remodelling of downstream aortic segments in acute and chronic thoracic aortic dissections. METHODS: Over a 4-year period, 65 patients (48 men, aged 61 ± 12 years) underwent total aortic arch replacement using the frozen elephant trunk technique for acute (n = 31) and chronic (n = 34) thoracic aortic dissections at our institution...
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29470557/design-of-a-3d-printed-open-source-wrist-driven-orthosis-for-individuals-with-spinal-cord-injury
#3
Alexandra A Portnova, Gaurav Mukherjee, Keshia M Peters, Ann Yamane, Katherine M Steele
Assistive technology, such as wrist-driven orthoses (WDOs), can be used by individuals with spinal cord injury to improve hand function. A lack of innovation and challenges in obtaining WDOs have limited their use. These orthoses can be heavy and uncomfortable for users and also time-consuming for orthotists to fabricate. The goal of this research was to design a WDO with user (N = 3) and orthotist (N = 6) feedback to improve the accessibility, customizability, and function of WDOs by harnessing advancements in 3D-printing...
2018: PloS One
https://www.readbyqxmd.com/read/29470276/anatomical-feasibility-of-extradural-transferring-s2-and-s3-ventral-roots-to-s1-ventral-root-for-restoring-neurogenic-bladder-in-spinal-cord-injury
#4
Kaixiang Yang, Hongtao Chen, Jian Tang, Dawei Ge, Sheng Zhang, Tao Sui, Xiaojian Cao
STUDY DESIGN: Anatomic study in 6 formalin-fixed cadavers. OBJECTIVE: To determine the anatomical feasibility of transferring the S2 and S3 ventral roots (VRs) to S1 VR as a method for restoring bladder dysfunction in spinal cord injury. SUMMARY OF BACKGROUND DATA: A large quantity of researches of neuroanastomosis methods have been used for treating the bladder dysfunction in spinal cord injury (SCI). However, some limitations retard the development of those studies...
February 21, 2018: Spine
https://www.readbyqxmd.com/read/29470149/chronic-complete-cervical-6-7-cord-transection-distinct-autonomic-and-cardiac-deficits
#5
Heidi L Lujan, Anne Tonson, Robert W Wiseman, Stephen E DiCarlo
Spinal cord injury (SCI) resulting in tetraplegia is a devastating, life-changing insult causing paralysis and sensory impairment as well as distinct autonomic dysfunction that triggers compromised cardiovascular, bowel, bladder and sexual activity. Life becomes a battle for independence as even routine bodily functions and the smallest activity of daily living become a major challenge. Accordingly, there is a critical need for a chronic pre-clinical model of tetraplegia. This report addresses this critical need by comparing, for the first time, resting, reflex and stress-induced cardiovascular, autonomic and hormonal responses each week for 4 weeks in 12 sham-operated intact rats and 12 rats with chronic, complete C6-7 spinal cord transection...
February 22, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29469801/undisturbed-characteristic-herpes-simplex-virus-2-outbreak
#6
Lainee S Goettsche, Karolyn A Wanat
Herpes simplex virus 2 (HSV-2) is a common sexually transmitted disease that typically presents with focal erosions or small vesicles on an erythematous base.Herein, a case is described in which a 42-year old man experienced a genital HSV-2 outbreak after sustaining a spinal cord injury. No typical prodromal symptomswere experienced; therefore the vesicular lesions remained completely intact, granting an unusual opportunity to visualize herpetic infection in its most classic morphology.
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469182/identification-of-the-novel-allele-hla-a-01-234-in-the-mother-of-a-german-cord-blood-donor
#7
J Strobel, B Hauck-Dlimi, K Dullinger, V Weisbach, J Zingsem
HLA-A*01:234 was identified by next generation sequencing and confirmed by Sanger sequencing.
February 22, 2018: HLA
https://www.readbyqxmd.com/read/29468441/a-new-minimally-invasive-technique-for-lead-revision-of-perc-paddle-leads
#8
Olivier De Coster, Patrice Forget, Maarten Moens, Milica Matic, Lucie Choustoulakis, Jan Poelaert
To report on a less-invasive technique for replacing a broken lead in a spinal cord stimulation (SCS) device that makes use of St. Jude Medical's "Epiducer" device. A 53-year-old woman suffered a loss of stimulation on her internal pulse generator (IPG), which was found to have a broken lead. The broken lead was withdrawn using the Epiducer device with minimal invasiveness and without pain. A new lead was put in place, and successful stimulation using the IPG resumed. Follow-up 3 weeks later showed a well-functioning SCS system...
February 21, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29468298/endoscopy-histology-and-electron-microscopy-analysis-of-foetal-membranes-in-pregnant-south-american-plains-vizcacha-reveal-unusual-excrescences-on-the-yolk-sac
#9
Mariela Giacchino, Pablo I F Inserra, Fernando D Lange, María C Gariboldi, Sergio R Ferraris, Alfredo D Vitullo
The South American hystricognathe Lagostomus maximus is a fossorial rodent whose females show unique reproductive characteristics. They have a 155-day long gestation, show massive polyovulation and a selective process of embryonic resorption in the first half of gestation. In order to explore and perform an in-situ characterization of the reproductive tract, we visualized internal structures through ultrasonography and video-endoscopy in pregnant and non-pregnant females. We describe the finding of protruding structures that lie on the yolk sac and their histological and ultrastructural characterization...
February 21, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29468257/aurora-kinase-b-regulates-axonal-outgrowth-and-regeneration-in-the-spinal-motor-neurons-of-developing-zebrafish
#10
Serene S L Gwee, Rowan A W Radford, Sharron Chow, Monisha D Syal, Marco Morsch, Isabel Formella, Albert Lee, Emily K Don, Andrew P Badrock, Nicholas J Cole, Adrian K West, Steve N S Cheung, Roger S Chung
Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in orchestrating cell division and cytokinesis, and is prominently expressed in healthy proliferating and cancerous cells. However, the role of AurkB in differentiated and non-dividing cells has not been extensively explored. Previously, we have described a significant upregulation of AurkB expression in cultured cortical neurons following an experimental axonal transection. This is somewhat surprising, as AurkB expression is generally associated only with dividing cells Frangini et al...
February 21, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29468227/solitary-mastocytoma-in-the-eyelid-of-an-adult
#11
Elizabeth L McKinnon, Andrew J Rand, Alan D Proia
Purpose: To describe the ophthalmic symptoms and histopathological findings in a rare case of an eyelid mastocytoma in an adult. Observations: A man in his early 60s developed a painless, non-tender, non-pruritic, mobile nodule on the right lower eyelid beneath the inferior orbital rim. The lesion grew to 15 × 9 mm over eleven months. Biopsy revealed a diffuse infiltrate of histiocytoid and spindle-shaped mast cells forming cords and small nests between collagen fibers in the superficial and deep dermis...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29467973/a-descriptive-analysis-of-the-use-of-twitter-by-emergency-medicine-residency-programs
#12
David Diller, Lalena M Yarris
Background : Twitter is increasingly recognized as an instructional tool by the emergency medicine (EM) community. In 2012, the Council of Residency Directors in Emergency Medicine (CORD) recommended that EM residency programs' Twitter accounts be managed solely by faculty. To date, little has been published regarding the patterns of Twitter use by EM residency programs. Objective : We analyzed current patterns in Twitter use among EM residency programs with accounts and assessed conformance with CORD recommendations...
February 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29467717/thioredoxin-1-protects-spinal-cord-from-demyelination-induced-by-methamphetamine-through-suppressing-endoplasmic-reticulum-stress-and-inflammation
#13
Lihua Yang, Yinli Guo, Mengbin Huang, Xiaoli Wu, Xiang Li, Guobing Chen, Ye Li, Jie Bai
Methamphetamine (METH) is a psychostimulant abused around the world. Emerging evidence indicates that METH causes brain damage. However, there are very few reports on METH-induced demyelination. Thioredoxin-1 (Trx-1) is a redox regulating protein and plays the roles in protecting neurons from various stresses. However, whether Trx-1 resists demyelination induced by METH has not been reported. In this study, we found that METH-induced thin myelin sheaths in spinal cord, whereas Trx-1 overexpression transgenic (TG) mice restored the myelin sheaths thickness...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29467709/delayed-latency-of-postural-muscles-of-individuals-with-intellectual-disabilities
#14
J Walter Tolentino-Castro, Andreas Mühlbeier, Luis Mochizuki, Heiko Wagner
Individuals with intellectual disabilities (ID) (50 < IQ < 79) show impaired motor and postural control, these impairments are highly related to falls and injuries. Recent studies demonstrated these impairments are related with fine and gross motor development, which are more strongly associated with cognition, and consequently language for individuals with ID than for without ID. Despite these studies, little is known about the structure and functioning of this population's spinal cord, which is highly involved in postural control...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29467518/is-umbilical-coiling-genetically-determined
#15
Nina K Ayala, Linda M Ernst, Emily S Miller
OBJECTIVE: Abnormal umbilical cord coiling is associated with adverse perinatal outcomes; however, the etiology of the umbilical coiling pattern is poorly understood. STUDY DESIGN: Retrospective cohort of all twin deliveries >20 weeks in 2014. Pregnancies were dichotomized by chorionicity and the umbilical coiling index (UCI) and placental cord insertion location were compared. In cases with one or both cords hypercoiled, the direction and pattern of coiling were compared by chorionicity...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29467001/neuregulin-1-elicits-a-regulatory-immune-response-following-traumatic-spinal-cord-injury
#16
Arsalan Alizadeh, Kallivalappil T Santhosh, Hardeep Kataria, Abdelilah S Gounni, Soheila Karimi-Abdolrezaee
BACKGROUND: Spinal cord injury (SCI) triggers a robust neuroinflammatory response that governs secondary injury mechanisms with both degenerative and pro-regenerative effects. Identifying new immunomodulatory therapies to promote the supportive aspect of immune response is critically needed for the treatment of SCI. We previously demonstrated that SCI results in acute and permanent depletion of the neuronally derived Neuregulin-1 (Nrg-1) in the spinal cord. Increasing the dysregulated level of Nrg-1 through acute intrathecal Nrg-1 treatment enhanced endogenous cell replacement and promoted white matter preservation and functional recovery in rat SCI...
February 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29466978/repeated-electroacupuncture-treatment-attenuated-hyperalgesia-through-suppression-of-spinal-glial-activation-in-chronic-neuropathic-pain-rats
#17
Jun-Ying Wang, Yong-Hui Gao, Li-Na Qiao, Jian-Liang Zhang, Cheng-Lin Duan-Mu, Ya-Xia Yan, Shu-Ping Chen, Jun-Ling Liu
BACKGROUND: Cumulated evidence reveals that glial cells in the spinal cord play an important role in the development of chronic neuropathic pain and are also complicated in the analgesic effect of EA intervention. But the roles of microgliacytes and astrocytes of spinal cord in the process of EA analgesia remain unknown. METHODS: A total of 120 male Wistar rats were used in the present study. The neuropathic pain model was established by chronic constrictive injury (CCI) of the sciatic nerve...
February 21, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29466910/the-role-of-ventral-tegmental-area-gaba-on-the-chronic-neuropathic-pain-following-spinal-cord-injury-in-rat
#18
Moon Yi Ko, Eun Young Jang, June Yeon Lee, Su Phil Kim, Sung Hun Whang, Bong Hyo Lee, Hee Young Kim, Char Ha Yang, Hee Jung Cho, Young Seob Gwak
Spinal cord injury (SCI) frequently results in chronic neuropathic pain (CNP). However, the understanding of brain neural circuits in CNP modulation is unclear. The present study examined the changes of ventral tegmental area (VTA) putative GABAergic and dopaminergic neuronal activity with CNP attenuation in rats. SCI was established by T10 clip compression injury (35 g, 1 min) in rats, and neuropathic pain behaviors, in vivo extracellular single cell recording of putative VTA GABA/dopamine neurons, extracellular GABA level, glutamic acid decarboxylase (GAD) and vesicular GABA transporters (VGAT) were measured in the VTA, respectively...
February 21, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29466745/massively-parallel-single-nucleus-transcriptional-profiling-defines-spinal-cord-neurons-and-their-activity-during-behavior
#19
Anupama Sathyamurthy, Kory R Johnson, Kaya J E Matson, Courtney I Dobrott, Li Li, Anna R Ryba, Tzipporah B Bergman, Michael C Kelly, Matthew W Kelley, Ariel J Levine
To understand the cellular basis of behavior, it is necessary to know the cell types that exist in the nervous system and their contributions to function. Spinal networks are essential for sensory processing and motor behavior and provide a powerful system for identifying the cellular correlates of behavior. Here, we used massively parallel single nucleus RNA sequencing (snRNA-seq) to create an atlas of the adult mouse lumbar spinal cord. We identified and molecularly characterized 43 neuronal populations. Next, we leveraged the snRNA-seq approach to provide unbiased identification of neuronal populations that were active following a sensory and a motor behavior, using a transcriptional signature of neuronal activity...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29466494/granulocyte-colony-stimulating-factor-combined-with-methylprednisolone-improves-functional-outcomes-in-rats-with-experimental-acute-spinal-cord-injury
#20
William Gemio Jacobsen Teixeira, Alexandre Fogaça Cristante, Raphael Martus Marcon, Gustavo Bispo, Ricardo Ferreira, Tarcísio Eloy Pessoa de Barros-Filho
OBJECTIVES: To evaluate the effects of combined treatment with granulocyte colony-stimulating factor (G-CSF) and methylprednisolone in rats subjected to experimental spinal cord injury. METHODS: Forty Wistar rats received a moderate spinal cord injury and were divided into four groups: control (no treatment); G-CSF (G-CSF at the time of injury and daily over the next five days); methylprednisolone (methylprednisolone for 24 h); and G-CSF/Methylprednisolone (methylprednisolone for 24 h and G-CSF at the time of injury and daily over the next five days)...
February 19, 2018: Clinics
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